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Journal articles on the topic 'Encapsulated peptide'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Drury, Jeanie L., Tanyarut Boontheekul, and David J. Mooney. "Cellular Cross-linking of Peptide Modified Hydrogels." Journal of Biomechanical Engineering 127, no. 2 (2004): 220–28. http://dx.doi.org/10.1115/1.1865194.

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Peptide modification of hydrogel-forming materials is being widely explored as a means to regulate the phenotype of cells immobilized within the gels. Alternatively, we hypothesized that the adhesive interactions between cells and peptides coupled to the gel-forming materials would also enhance the overall mechanical properties of the gels. To test this hypothesis, alginate polymers were modified with RGDSP-containing peptides and the resultant polymer was used to encapsulate C2C12 myoblasts. The mechanical properties of these gels were then assessed as a function of both peptide and cell dens

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Cresti, Laura, Gemma Conte, Giovanni Cappello, et al. "Inhalable Polymeric Nanoparticles for Pulmonary Delivery of Antimicrobial Peptide SET-M33: Antibacterial Activity and Toxicity In Vitro and In Vivo." Pharmaceutics 15, no. 1 (2022): 3. http://dx.doi.org/10.3390/pharmaceutics15010003.

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Development of inhalable formulations for delivering peptides to the conductive airways and shielding their interactions with airway barriers, thus enhancing peptide/bacteria interactions, is an important part of peptide-based drug development for lung applications. Here, we report the construction of a biocompatible nanosystem where the antimicrobial peptide SET-M33 is encapsulated within polymeric nanoparticles of poly(lactide-co-glycolide) (PLGA) conjugated with polyethylene glycol (PEG). This system was conceived for better delivery of the peptide to the lungs by aerosol. The encapsulated

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Santos, Daniel Moreira dos, Livia Ramos Santiago, Nayara Araújo dos Santos, et al. "Encapsulated LyeTx III Peptide: Cytotoxic Agent Isolated from Lycosa erythrognatha Spider Venom." Toxins 17, no. 1 (2025): 32. https://doi.org/10.3390/toxins17010032.

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The discovery of novel cytotoxic drugs is of paramount importance in contemporary medical research, particularly in the search for treatments with fewer side effects and higher specificity. Antimicrobial peptides are an interesting class of molecules for this endeavor. In this context, the LyeTx III, a new peptide extracted from the venom of the Lycosa erythrognatha spider, stands out. The peptide exhibits typical antimicrobial traits: a positive net charge and amphipathic α -helix structure in lipid-like environments. Its unique sequence (GKAMKAIAKFLGR-NH2), identified via mass spectrometry a

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Nakamura, Yoko, Yuki Sato, Hiroshi Inaba, Takashi Iwasaki та Kazunori Matsuura. "Encapsulation of mRNA into Artificial Viral Capsids via Hybridization of a β-Annulus-dT20 Conjugate and the Poly(A) Tail of mRNA". Applied Sciences 10, № 22 (2020): 8004. http://dx.doi.org/10.3390/app10228004.

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Messenger RNA (mRNA) drugs have attracted considerable attention as promising tools with many therapeutic applications. The efficient delivery of mRNA drugs using non-viral materials is currently being explored. We demonstrate a novel concept where mCherry mRNA bearing a poly(A) tail is encapsulated into capsids co-assembled from viral β-annulus peptides bearing a 20-mer oligothymine (dT20) at the N-terminus and unmodified peptides via hybridization of dT20 and poly(A). Dynamic light scattering measurements and transmission electron microscopy images of the mRNA-encapsulated capsids show the f

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Sone, Eli D., and Samuel I. Stupp. "Semiconductor-Encapsulated Peptide−Amphiphile Nanofibers." Journal of the American Chemical Society 126, no. 40 (2004): 12756–57. http://dx.doi.org/10.1021/ja0499344.

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Sodhi, Harkanwalpreet, and Alyssa Panitch. "A Tunable Glycosaminoglycan–Peptide Nanoparticle Platform for the Protection of Therapeutic Peptides." Pharmaceutics 16, no. 2 (2024): 173. http://dx.doi.org/10.3390/pharmaceutics16020173.

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The popularity of Glycosaminoglycans (GAGs) in drug delivery systems has grown as their innate ability to sequester and release charged molecules makes them adept in the controlled release of therapeutics. However, peptide therapeutics have been relegated to synthetic, polymeric systems, despite their high specificity and efficacy as therapeutics because they are rapidly degraded in vivo when not encapsulated. We present a GAG-based nanoparticle system for the easy encapsulation of cationic peptides, which offers control over particle diameter, peptide release behavior, and swelling behavior,

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Gao, Jinhong, Heng Du, Zhenhong Zhang, et al. "Design and Characterization of Peptide-Based Self-Assembling Microgel for Encapsulation of Sesaminol." Foods 14, no. 6 (2025): 971. https://doi.org/10.3390/foods14060971.

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Sesaminol is a natural functional compound of sesame with low bioaccessibility due to its high crystallinity. Here, a peptide-based self-assembly microgel was constructed to encapsulate sesaminol, reducing its crystallinity and improving its bioaccessibility. In this contribution, the peptide AcNH-Leu-Tyr-Tyr-CONH2 (LYY) was shown to form a mesoporous three-dimensional (3D) microgel through microstructure characterization. Various characterization methods revealed that the LYY peptide self-assembled through β-folds and random coils, and the primary intermolecular interactions arose from hydrog

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Zhang, Zaiyuan, Zhong Chen, Ling Yang, et al. "Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury." Journal of Functional Biomaterials 13, no. 4 (2022): 181. http://dx.doi.org/10.3390/jfb13040181.

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Clinically, antioxidant therapy is a potential strategy for myocardial ischemia-reperfusion injury (MI/RI), a common complication of acute myocardial ischemia. The H-D-Arg-Dmt-Ly-Phe-NH2 (SS31) peptide is shown to have amazing antioxidant properties, but its utilization is limited by the peptide characteristics, such as the destruction by proteases and rapid metabolism. Silica nanoparticles (MSNs) comprise an excellent material for peptide delivery, owing to the protection effect relating to peptides. Moreover, platelet membrane (PLTM) is shown to be advantageous as a coat for nanosystems beca

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Alvarado, Yolanda, Claudia Muro, Javier Illescas, María del Carmen Díaz, and Francisco Riera. "Encapsulation of Antihypertensive Peptides from Whey Proteins and Their Releasing in Gastrointestinal Conditions." Biomolecules 9, no. 5 (2019): 164. http://dx.doi.org/10.3390/biom9050164.

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Antihypertensive peptide fraction from whey protein hydrolysate <3 kDa (measured as angiotensin-converting enzyme (ACE) activity %) was isolated and encapsulated into three composite materials: alginate–collagen, alginate Arabic gum, and alginate–gelatin. The release behavior of peptide fraction from capsules was analyzed according to the encapsulation material efficiency, the characteristics of the capsules, and the released antihypertensive peptides during gastrointestinal digestion. The highest encapsulation efficiency was found in capsules of alginate Arabic gum (95%). In this case, the

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Vashi, Ankur. "Therapeutic Peptides Encapsulated into Lipid-Based Nanovesicles: Scaling from Lab to Plant." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 11 (2024): 1–4. http://dx.doi.org/10.55041/ijsrem38468.

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Lipid-based peptide-encapsulated nanovesicles represent a cutting-edge approach in drug delivery systems, offering enhanced stability, targeted delivery, and controlled release of therapeutic peptides. This review explores the comprehensive science and techniques behind the robust formulation and analytical methods for these nanovesicles, spanning from lab-scale research to large- scale manufacturing. Critical aspects include lipid selection, detailing how the choice of lipids impacts the stability and efficacy of the nanovesicles, and various peptide encapsulation techniques, emphasizing meth

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Raghavender, Upadhyayula S., Kantharaju, Subrayashastry Aravinda, Narayanaswamy Shamala, and Padmanabhan Balaram. "Hydrophobic Peptide Channels and Encapsulated Water Wires." Journal of the American Chemical Society 132, no. 3 (2010): 1075–86. http://dx.doi.org/10.1021/ja9083978.

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12

Prencipe, Filippo, Carlo Diaferia, Filomena Rossi, Luisa Ronga, and Diego Tesauro. "Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides." Molecules 26, no. 13 (2021): 4049. http://dx.doi.org/10.3390/molecules26134049.

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Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects. Active targeting by means of drug-encapsulated micelles decorated with targeting bioactive moieties represents a new frontier. Between the bioactive moieties, peptides, for their versatility, easy synthesis and immunogenicity, can be selected to direct a drug toward a considerable number of molecular targets overexpressed on both cancer vasculature and cancer cells. Moreover, short peptide sequences can

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Laughlin, Taylor D., Jeremy R. Miles, Elane C. Wright-Johnson, Lea A. Rempel, Clay A. Lents, and Angela K. Pannier. "Development of pre-implantation porcine blastocysts cultured within alginate hydrogel systems either supplemented with secreted phosphoprotein 1 or conjugated with Arg-Gly-Asp Peptide." Reproduction, Fertility and Development 29, no. 12 (2017): 2345. http://dx.doi.org/10.1071/rd16366.

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Although deficiencies in porcine blastocyst elongation play a significant role in early embryonic mortality and establishment of within-litter developmental variation, the exact mechanisms of elongation are poorly understood. Secreted phosphoprotein 1 (SPP1) is increased within the uterine milieu during early porcine pregnancy and contains an Arg-Gly-Asp (RGD) peptide sequence that binds to cell surface integrins on the uterine endometrium and trophectoderm, promoting cell adhesion and migration. The aim of the present study was to evaluate the development of preimplantation porcine blastocyst

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Beddow, Sara A., Tobias Neef, Igal Ifergan, Joseph R. Podojil, Daniel Getts, and Stephen D. Miller. "Treatment with Multiple-linked Myelin Peptides Encapsulated within Nanoparticles Induces Antigen-specific Tolerance in SJL/J Relapsing-remitting Experimental Autoimmune Encephalomyelitis." Journal of Immunology 204, no. 1_Supplement (2020): 160.10. http://dx.doi.org/10.4049/jimmunol.204.supp.160.10.

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Abstract Experimental autoimmune encephalomyelitis (EAE) in SJL/J mice is a demyelinating disease of the central nervous system (CNS), and serves as a fit-for-purpose pre-clinical model of Multiple Sclerosis (MS). Data show that tolerogenic immune-modifying nanoparticles (TIMPs) encapsulating peptides/proteins is an effective therapeutic that induces antigen-specific tolerance to the encapsulated peptide/protein. The effectiveness of this therapeutic platform has been be demonstrated in multiple mouse models, as well as in a recently completed phase 2 double-blinded placebo-controlled clinical

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15

Depta, Julia, Paulina Małkowska, Monika Wysokińska, et al. "Therapeutic Role of Antimicrobial Peptides in Diabetes Mellitus." Biologics 2, no. 1 (2022): 92–106. http://dx.doi.org/10.3390/biologics2010008.

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Antimicrobial peptides (AMPs) have recently become widely publicized because they have the potential to function in alternative therapies as “natural” antibiotics, with their main advantage being a broad spectrum of activity. The potential for antimicrobial peptides to treat diabetes mellitus (DM) has been reported. In diabetes mellitus type I (T1D), cathelicidin-related antimicrobial peptide (CRAMP), cathelicidin antimicrobial peptide (CAMP) and mouse-β- defensin 14 (mBD14) are positively affected. Decreased levels of LL-37 and human neutrophil peptide 1-3 (HNP1-3) have been reported in diabe

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Xing, Mingxia, Ying Ji, Lianzhong Ai, Fan Xie, Yan Wu, and Phoency F. H. Lai. "Improving Effects of Laccase-Mediated Pectin–Ferulic Acid Conjugate and Transglutaminase on Active Peptide Production in Bovine Lactoferrin Digests." Catalysts 13, no. 3 (2023): 521. http://dx.doi.org/10.3390/catal13030521.

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Bovine lactoferrin (bLf) is a multifunctional glycoprotein and a good candidate for producing diverse bioactive peptides, which are easily lost during over-digestion. Accordingly, the effects of laccase-mediated pectin–ferulic acid conjugate (PF) and transglutaminase (TG) on improving the production of bLf active peptides by in vitro gastrointestinal digestion were investigated. Using ultra-high-performance liquid chromatography tandem mass spectroscopy (UPLC-MS-MS), the digests of bLf alone, PF-encapsulated bLf complex (LfPF), and TG-treated LfPF complex (LfPFTG) produced by conditioned in vi

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Shu, Chang, Eboka Majolene B. Sabi-mouka, Wen Yang, Zhongyang Li, and Li Ding. "Effects of paclitaxel (PTX) prodrug-based self-assembly peptide hydrogels combined with suberoylanilide hydroxamic acid (SAHA) for PTX-resistant cancer and synergistic antitumor therapy." RSC Advances 6, no. 103 (2016): 100765–71. http://dx.doi.org/10.1039/c6ra19917h.

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18

Cruz-Casas, Dora Elisa, Rodolfo Ramos-González, Lilia Arely Prado-Barragán, et al. "Antihypertensive Amaranth Protein Hydrolysates Encapsulation in Alginate/Pectin Beads: Influence on Bioactive Properties upon In Vitro Digestion." Polysaccharides 5, no. 3 (2024): 450–62. http://dx.doi.org/10.3390/polysaccharides5030028.

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Protein hydrolysates containing bioactive peptides have emerged as therapeutic agents. However, these peptides may lose this bioactivity under gastrointestinal conditions. Encapsulation in edible biopolymers is a solution to this problem. Protein hydrolysates with ACE-I inhibitory activity, obtained previously, were encapsulated. A 1% solution of the biopolymers alginate (AG) and pectin (PC) in various ratios was prepared. The beads formed were evaluated in both wet and dry states for size, roundness, thermal gravimetric analysis (TGA), encapsulation efficiency, and ACE-I inhibitory activity.

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19

Soukasene, Stephen, Daniel J. Toft, Tyson J. Moyer, et al. "Antitumor Activity of Peptide Amphiphile Nanofiber-Encapsulated Camptothecin." ACS Nano 5, no. 11 (2011): 9113–21. http://dx.doi.org/10.1021/nn203343z.

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20

Medina, Scott H., Sandra Li, O. M. Zack Howard, et al. "Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels." Biomaterials 53 (June 2015): 545–53. http://dx.doi.org/10.1016/j.biomaterials.2015.02.125.

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21

Mann, Florian A., Jan Horlebein, Nils Frederik Meyer, Daniel Meyer, Franziska Thomas, and Sebastian Kruss. "Carbon Nanotubes Encapsulated in Coiled-Coil Peptide Barrels." Chemistry - A European Journal 24, no. 47 (2018): 12241–45. http://dx.doi.org/10.1002/chem.201800993.

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22

Qiao, Zeng-Ying, Chun-Yuan Hou, Di Zhang та ін. "Self-assembly of cytotoxic peptide conjugated poly(β-amino ester)s for synergistic cancer chemotherapy". Journal of Materials Chemistry B 3, № 15 (2015): 2943–53. http://dx.doi.org/10.1039/c4tb02144d.

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23

Gallarate, Marina, Luigi Battaglia, E. Peira, and Michele Trotta. "Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique." International Journal of Chemical Engineering 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/132435.

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Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations. Insulin and leuprolide, chosen as model peptide drugs, were encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants. Peptide integrity was maintained after encapsulation, and nanoparticles can actin vitroas a sustained rele

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Han, Felicity Y., Weizhi Xu, Vinod Kumar, et al. "Optimisation of a Microfluidic Method for the Delivery of a Small Peptide." Pharmaceutics 13, no. 9 (2021): 1505. http://dx.doi.org/10.3390/pharmaceutics13091505.

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Peptides hold promise as therapeutics, as they have high bioactivity and specificity, good aqueous solubility, and low toxicity. However, they typically suffer from short circulation half-lives in the body. To address this issue, here, we have developed a method for encapsulation of an innate-immune targeted hexapeptide into nanoparticles using safe non-toxic FDA-approved materials. Peptide-loaded nanoparticles were formulated using a two-stage microfluidic chip. Microfluidic-related factors (i.e., flow rate, organic solvent, theoretical drug loading, PLGA type, and concentration) that may pot

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Bae, Jooeun, Parayath Neha, Mansoor Amiji, Nikhil Munshi, and Kenneth Anderson. "Bcma Heteroclitic Peptide Encapsulated Nanoparticle Enhances Antigen Stimulatory Capacity and Tumor-Specific CD8+ cytotoxic T Lymphocytes Against Multiple Myeloma." Blood 132, Supplement 1 (2018): 3195. http://dx.doi.org/10.1182/blood-2018-99-117292.

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Abstract Background: B-cell Maturation Antigen (BCMA), a member of the tumor necrosis factor (TNF) receptor superfamily and the receptor for binding of B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), is a promising therapeutic target for MM. Due to its restricted expression pattern on MM cells and plasma cells along with its role in promoting MM cells growth, survival, and drug resistance, BCMA is being targeted by several immunotherapeutic strategies including antibodies, immunotoxins, bispecific T-cell engagers, and CAR-T cells. Recently, we have identified nanom

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Majumder, Poulami, Sukanya Bhunia, and Arabinda Chaudhuri. "A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy." Chemical Communications 54, no. 12 (2018): 1489–92. http://dx.doi.org/10.1039/c7cc08517f.

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Butreddy, Arun, Rajendra Prasad Gaddam, Nagavendra Kommineni, Narendar Dudhipala, and Chandrashekhar Voshavar. "PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery." International Journal of Molecular Sciences 22, no. 16 (2021): 8884. http://dx.doi.org/10.3390/ijms22168884.

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Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled drug delivery to reduce dosing frequency and to improve the therapeutic effects. Biopharmaceuticals such as proteins and peptides are encapsulated in the microspheres to increase their bioavailability and provide a long release period (days or months) with constant drug plasma concentration. The biodegradable and biocompatible properties of PLGA/PLA polymers, including but not limited to molecular weight, end group, lac

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Kogiso, Masaki, Wu Xiao Ding, and Mitsutoshi Masuda. "Mass-Producible Organic Nanocapsule with Water-Responsive Releasing Ability." Materials Science Forum 916 (March 2018): 14–18. http://dx.doi.org/10.4028/www.scientific.net/msf.916.14.

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An organic nanocapsule was obtained by mixing zinc acetate powder into a peptide lipid dispersion in ethanol. The nanocapsule was mass-produced at a scale of over 100 g L–1 within 1 h. Fourier transform infrared spectroscopy and scanning electron microscopy revealed that a zinc-peptide lipid complex was formed within 15 min, which subsequently transformed into a nanocapsule as a result of changes in the hydrogen bonding networks between the peptides. A variety of organic dyes could be encapsulated by simply adding them during the nanocapsule formation. We also confirmed their high stabilities

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Cinar, Goksu, Ayse Ozdemir, Seren Hamsici, et al. "Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels." Biomaterials Science 5, no. 1 (2017): 67–76. http://dx.doi.org/10.1039/c6bm00656f.

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Afami, Marina E., Ikhlas El Karim, Imad About, Sophie M. Coulter, Garry Laverty, and Fionnuala T. Lundy. "Ultrashort Peptide Hydrogels Display Antimicrobial Activity and Enhance Angiogenic Growth Factor Release by Dental Pulp Stem/Stromal Cells." Materials 14, no. 9 (2021): 2237. http://dx.doi.org/10.3390/ma14092237.

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Recent studies on peptide hydrogels have shown that ultrashort peptides (<8 amino acids) can self-assemble into hydrogels. Ultrashort peptides can be designed to incorporate antimicrobial motifs, such as positively charged lysine residues, so that the peptides have inherent antimicrobial characteristics. Antimicrobial hydrogels represent a step change in tissue engineering and merit further investigation, particularly in applications where microbial infection could compromise healing. Herein, we studied the biocompatibility of dental pulp stem/stromal cells (DPSCs) with an ultrashort peptid

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Phillips, Joy A., Shailendra B. Tallapaka, Joseph A. Vetro, Sam D. Sanderson, and Marilyn L. Thoman. "Musocal vaccine for universal influenza A protection." Journal of Immunology 196, no. 1_Supplement (2016): 145.16. http://dx.doi.org/10.4049/jimmunol.196.supp.145.16.

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Abstract The rapid mutation rate of the influenza virus requires that the yearly flu vaccine development cycle start months in advance of the flu season. The search for a single vaccine able to protect against multiple strains of influenza has thus long been the Holy Grail of flu vaccine research. Such a vaccine would require an antigenic target that is highly or completely homologous among all influenza subtypes. There is one such conserved region present on the otherwise highly variable influenza A hemagglutinin protein. This short, linear peptide sequence known as the fusion peptide is high

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He, Guan Zhen, and Wen Jen Lin. "Peptide-Functionalized Nanoparticles-Encapsulated Cyclin-Dependent Kinases Inhibitor Seliciclib in Transferrin Receptor Overexpressed Cancer Cells." Nanomaterials 11, no. 3 (2021): 772. http://dx.doi.org/10.3390/nano11030772.

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Seliciclib, a broad cyclin-dependent kinases (CDKs) inhibitor, exerts its potential role in cancer therapy. For taking advantage of overexpressive transferrin receptor (TfR) on most cancer cells, T7 peptide, a TfR targeting ligand, was selected as a targeting ligand to facilitate nanoparticles (NPs) internalization in cancer cells. In this study, poly(d,l-lactide-co-glycolide) (PLGA) was conjugated with maleimide poly(ethylene glycol) amine (Mal-PEG-NH2) to form PLGA-PEG-maleimide copolymer. The synthesized copolymer was used to prepare NPs for encapsulation of seliciclib which was further dec

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Yen, Chia Liang, Chia Li Liao, Dar Bin Shieh, et al. "Poly Lactic-co-glycolic acid nanoparticles encapsulation enhance the effectiveness of curcumin for rescuing trafficking-defective gp91phox in chronic granulomatous disease leukocytes." Journal of Immunology 198, no. 1_Supplement (2017): 81.12. http://dx.doi.org/10.4049/jimmunol.198.supp.81.12.

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Abstract Mutations in leukocyte NADPH oxidase genes lead to defective reactive oxygen species (ROS) production and cause chronic granulomatous disease (CGD) in humans. Previously we have shown that the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump inhibitor, thapsigargin, rescues the endoplasmic reticulum (ER) retention of the mutant protein in a CGD patient with a gp91phox (H338Y) mutation. Curcumin, a natural constituent of Curcuma longa, is also a SERCA pump inhibitor. However, the clinical effectiveness of curcumin is not satisfactory due to its poor in vivo bioavailability and p

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Brown, Alexandra M., Yoliem S. Miranda-Alarćon, Grant A. Knoll, Anthony M. Santora, and Ipsita A. Banerjee. "Fetoprotein Derived Short Peptide Coated Nanostructured Amphiphilic Surfaces for Targeting Mouse Breast Cancer Cells." International Journal of Nanoscience 16, no. 01 (2017): 1650023. http://dx.doi.org/10.1142/s0219581x1650023x.

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In this work, self-assembled tumor targeting nanostructured surfaces were developed from a newly designed amphiphile by conjugating boc protected isoleucine with 2,[Formula: see text] ethylenedioxy bis ethylamine (IED). To target mouse mammary tumor cells, a short peptide sequence derived from the human alpha-fetoprotein (AFP), LSEDKLLACGEG was attached to the self-assembled nanostructures. Tumor targeting and cell proliferation were examined in the presence of nanoscale assemblies. To further obliterate mouse breast tumor cells, the chemotherapeutic drug tamoxifen was then entrapped into the

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Xu, Yining, Matthias Van Hul, Francesco Suriano, Véronique Préat, Patrice D. Cani, and Ana Beloqui. "Novel strategy for oral peptide delivery in incretin-based diabetes treatment." Gut 69, no. 5 (2019): 911–19. http://dx.doi.org/10.1136/gutjnl-2019-319146.

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ObjectiveTo fulfil an unmet therapeutic need for treating type 2 diabetes by developing an innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide-1 (GLP-1) and the absorption of peptides into the circulation.DesignWe developed a nanocarrier for the oral delivery of peptides using lipid-based nanocapsules. We encapsulated the GLP-1 analogue exenatide within nanocapsules and investigated in vitro in human L-cells (NCl-H716) and murine L-cells (GLUTag cells) the ability of the nanosystem to trigger GLP-1 secretion. The therapeutic relevance of the nanosystem i

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Spreitzer, Glen, Jacqueline M. Whitling, Jeffry D. Madura, and David W. Wright. "Peptide-encapsulated CdS nanoclusters from a combinatorial ligand library." Chemical Communications, no. 3 (2000): 209–10. http://dx.doi.org/10.1039/a907178d.

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Slocik, Joseph M., Joshua T. Moore, and David W. Wright. "Monoclonal Antibody Recognition of Histidine-Rich Peptide Encapsulated Nanoclusters." Nano Letters 2, no. 3 (2002): 169–73. http://dx.doi.org/10.1021/nl015706l.

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A. Hussein, Ahmed. "Preparation and Characterization of Poly (D,L-Lactide-Co-Glycolide) Microspheres for Controlled Release of KSL Peptide." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 16, no. 1 (2017): 26–33. http://dx.doi.org/10.31351/vol16iss1pp26-33.

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The purpose of this research was to prepare, characterize, and evaluate the new antimicrobial peptide KSL peptide encapsulated in poly(D,L-lactide-co-glycolide) (PLGA)composite microspheres. KSL was loaded in poly(acryloyl hydroxyethyl) starch (acHES) micropar-ticles, and then the peptide-containing microparticles were encapsulated in the PLGA matrix by a solvent extraction /evaporation method. KSL-loaded PLGA microspheres were also prepared without the starch hydrogel microparticle microspheres for comparison study. KSL peptide microspheres were characterized for drug content, surface m

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Tikhonov, S. L., N. V. Tikhonova, N. A. Kolberg, A. S. Ozhgikhina, and S. V. Shikhalev. "Microcapsulation and evaluation of subchronic toxicity of peptides extracted from cow colostrum and peptides of Fabricius bursa extract of broiler chickens." Vestnik MGTU 25, no. 3 (2022): 207–18. http://dx.doi.org/10.21443/1560-9278-2022-25-3-207-218.

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Peptides have high biological activity and are used in the composition of medicines. Peptides are not widely used in food technology as they are sensitive to the action of proteolytic enzymes of the gastrointestinal tract and are characterized by rapid decomposition reducing their effectiveness. Colostrum of cows is a promising source of peptides with different functional orientations. One of the ways contributing to the expansion of using peptides when administered orally is their microcapsulation. The aim of the research is to develop a technology and method for microcapsulating peptides ext

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Zhao, Y. N., Y. N. Cao, J. Sun, et al. "Anti-breast cancer activity of resveratrol encapsulated in liposomes." Journal of Materials Chemistry B 8, no. 1 (2020): 27–37. http://dx.doi.org/10.1039/c9tb02051a.

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Lee, Bao-Hong, Bo-Rui Chen, Cheng-Ting Huang, and Cheng-Hui Lin. "The Immune Activity of PT-Peptide Derived from Anti-Lipopolysaccharide Factor of the Swimming Crab Portunus trituberculatus Is Enhanced when Encapsulated in Milk-Derived Extracellular Vesicles." Marine Drugs 17, no. 5 (2019): 248. http://dx.doi.org/10.3390/md17050248.

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PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), designated as EVs-PT peptide, on immune regulation. The results showed that raw milk-derived EVs efficaciously delivered the PT-peptide into monocytes and elevated immune activity, including reactive oxygen species level, superoxide anion production, and phagocytosis. PT-peptide and

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Cappiello, Floriana, Bruno Casciaro, Maria Rosa Loffredo, et al. "Pulmonary Safety Profile of Esc Peptides and Esc-Peptide-Loaded Poly(lactide-co-glycolide) Nanoparticles: A Promising Therapeutic Approach for Local Treatment of Lung Infectious Diseases." Pharmaceutics 14, no. 11 (2022): 2297. http://dx.doi.org/10.3390/pharmaceutics14112297.

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In recent years, we have discovered Esc(1-21) and its diastereomer (Esc peptides) as valuable candidates for the treatment of Pseudomonas lung infection, especially in patients with cystic fibrosis (CF). Furthermore, engineered poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) were revealed to be a promising pulmonary delivery system of antimicrobial peptides. However, the “ad hoc” development of novel therapeutics requires consideration of their stability, tolerability, and safety. Hence, by means of electrophysiology experiments and preclinical studies on healthy mice, we demonstrated th

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Silva-Barcellos, Neila M., Robson A. S. Santos, Sordaine Caligiorne, Marisa Lemos, and Frederic Frezard. "Long-Lasting Pressor Effect of Liposome-Encapsulated Angiotensin-(1-7) Following Unilateral Microinjection into the Rat Rostral Ventrolateral Medulla." Hypertension 36, suppl_1 (2000): 702–3. http://dx.doi.org/10.1161/hyp.36.suppl_1.702-d.

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P54 Several studies with vasoactive peptides in the rostral ventrolateral medulla (RVLM) have focused on their acute cardiovascular effects. However, information is still lacking on their long term effects in this key region for the central control of blood pressure. Sterically stabilized liposomes (SSL) represent an important tool for the slow release of bioative agents and the prolongation of their effect in vivo . In this work, we administered Angiotensin(Ang)-(1-7)-containing SSL in the RVLM and evaluated its effects on blood pressure (BP) and heart rate (HR). Ang-(1-7) was encapsulated in

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Nareman, Badri Arkan, Rasool Abbas Al-Khafaji Fadhil, and Hadi Al-Jebory Hashim. "Effect of Nano-Encapsulated Peptide on Some Blood Parameters of Broiler Exposed to Oxidative Stress." International Journal of Life Science and Agriculture Research 04, no. 05 (2025): 285–91. https://doi.org/10.5281/zenodo.15341399.

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The study was conducted on the Al-Anwar poultry farm, 360 broiler chicks (Ross 308) divided into six treatments (T1, T2, T3, T4, T5, T6). The treatments were as follows: T1 was the control treatment, T2 was the control treatment with 0.5% H2O2, and T3, T4, T5, T6 were the treatments that were supplemented with 1, 2, 3, and 4 ml of synthetic peptides with 0.5% H2O2. The results shown: significant increase for T2 in cholesterol, triglyceride, LDL, VLDL, glucose, uric acid, AST, ALT, significant increase for T2 and T3 in MDA level, significant increase for T4, T5, T6 in total protein, while signi

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Haggag, Yusuf, Kyle Matchett, Robert Falconer, et al. "Novel Ran-RCC1 Inhibitory Peptide-Loaded Nanoparticles Have Anti-Cancer Efficacy In Vitro and In Vivo." Cancers 11, no. 2 (2019): 222. http://dx.doi.org/10.3390/cancers11020222.

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The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer therapeutics due to their selectivity, high potency and lack of normal cell toxicity. Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therapeutic target in breast cancer, were delivered by entrapment into polyethylene glycol-poly (lactic-co-glycolic acid) PEG-PLGA polymeric nanopa

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Muraki, Yo, Yutaka Nishimoto, Midori Yamasaki, Shuuichi Miyakawa, and Shuji Sato. "The evaluation of lymph node cell proliferation response by liposomes loaded with major histocompatibility complex class II binding aquaporin 4 antigen peptide." Bioscience, Biotechnology, and Biochemistry 85, no. 3 (2020): 537–44. http://dx.doi.org/10.1093/bbb/zbaa084.

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ABSTRACT Autoimmune responses to aquaporin 4 (AQP4) cause neuromyelitis optica (NMO); thus, specific immunotolerance to this self-antigen could represent a new NMO treatment. We generated the liposome-encapsulated AQP4 peptide 201-220 (p201-220) to induce immunotolerance. Liposomes were generated using phosphatidylserine and the polyglycidol species PG8MG. The in vivo tissue distribution of the liposomes was tested using an ex vivo imaging system. To confirm the antigen presentation capacity of PG8MG liposomes, dendritic cells were treated with PG8MG liposome-encapsulated AQP4 p201-220 (AQP4-P

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Bazikov, I. A., A. N. Maltsev, O. I. Sedykh, V. A. Baturin, A. D. Bolatchiev, and A. A. Efremenko. "Isolation of endogenous antimicrobial peptides from blood cells." Bacteriology 5, no. 1 (2020): 33–36. http://dx.doi.org/10.20953/2500-1027-2020-1-33-36.

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A technique for isolating the endogenous antimicrobial peptides (AMP) has been developed. Leukocyte-erythrocyte-platelet blood mass of donors was used as the material for preparing endogenous AMP. The hydrolysate was obtained with the trypsin solution from this mass, and then the components were fractionated using the filter chromatography column (Simax CSN ISO 3585, Russia). For gel filtration, 1.5 g of Sephadex G-25 was applied to the filter surface followed by sterilizing filtration of the obtained substance through bactericidal filters having a pore diameter of 0.2 μm. The antimicrobial pe

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Nie, Shasha, Chunhua Ren, Xin Liang, et al. "Supramolecular Hydrogel-Wrapped Gingival Mesenchymal Stem Cells in Cutaneous Radiation Injury." Cells 11, no. 19 (2022): 3089. http://dx.doi.org/10.3390/cells11193089.

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Radiation-induced skin wound/dermatitis is one of the common side effects of radiotherapy or interventional radiobiology. Gingiva-derived mesenchymal stem cells (GMSCs) were indicated to have therapeutic potentials in skin diseases. However, stem cells are prone to spread and difficult to stay in the skin for a long time, limiting their curative effects and application. This study investigated the therapeutic efficacy of Nap-GDFDFpDY (pY-Gel) self-assembled peptide hydrogel-encapsulated GMSCs to treat 137Cs γ-radiation-induced skin wounds in mice. The effects were evaluated by skin damage scor

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Nakai, Takashi, Fumiyasu Momose, Kohei Yabuuchi, et al. "Abstract 6745: Crafting hyaluronic acid-based nanoparticles for enhanced LN targeting as a potent priming tool in immunotherapy." Cancer Research 84, no. 6_Supplement (2024): 6745. http://dx.doi.org/10.1158/1538-7445.am2024-6745.

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Abstract Background: Cholesterol-conjugated hyaluronic acid, synthesized by grafting cholesterol moieties onto hyaluronic acid, spontaneously formed nano-sized hydrogel of approximately 30-100nm in water. This hyaluronic acid derivative (HA nanogel) has demonstrated the ability to encapsulate various modalities, including low- and medium-sized molecules, peptides, and proteins. Previous reports have highlighted its efficacy in solubilizing poorly water-soluble drugs and serving as a sustained-release matrix. In this study, we explore the potential of HA nanogels encapsulating antigen peptides

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Li, Jieling, Yan Xue, Anhe Wang, Shaonan Tian, Qi Li, and Shuo Bai. "Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture." Gels 8, no. 6 (2022): 372. http://dx.doi.org/10.3390/gels8060372.

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The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should h

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