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Journal articles on the topic 'Encapsulating Placenta'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kroløkke, Charlotte, Elizabeth Dickinson, and Karen A. Foss. "The placenta economy: From trashed to treasured bio-products." European Journal of Women's Studies 25, no. 2 (2016): 138–53. http://dx.doi.org/10.1177/1350506816679004.

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This article examines the human placenta not only as a scientific, medical and biological entity but as a consumer bio-product. In the emergent placenta economy, the human placenta is exchanged and gains potentiality as food, medicine and cosmetics. Drawing on empirical research from the United States, the United Kingdom, Denmark and Japan, the authors use feminist cultural analysis and consumer theories to discuss how the placenta is exchanged and gains commodity status as a medical supplement, smoothie, pill and anti-ageing lotion. Placenta preparers and new mothers cite medical properties a

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2

Matsubara, Keiichi, Yuko Matsubara, Yuka Uchikura, and Takashi Sugiyama. "Pathophysiology of Preeclampsia: The Role of Exosomes." International Journal of Molecular Sciences 22, no. 5 (2021): 2572. http://dx.doi.org/10.3390/ijms22052572.

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The pathogenesis of preeclampsia begins when a fertilized egg infiltrates the decidua, resulting in implantation failure (e.g., due to extravillous trophoblast infiltration disturbance and abnormal spiral artery remodeling). Thereafter, large amounts of serum factors (e.g., soluble fms-like tyrosine kinase 1 and soluble endoglin) are released into the blood from the hypoplastic placenta, and preeclampsia characterized by multiorgan disorder caused by vascular disorders develops. Successful implantation and placentation require immune tolerance to the fertilized egg as a semi-allograft and the

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3

Papp, Nicole, Jeffin Panicker, John Rubino, et al. "In Vitro Nephrotoxicity and Permeation of Vancomycin Hydrochloride Loaded Liposomes." Pharmaceutics 14, no. 6 (2022): 1153. http://dx.doi.org/10.3390/pharmaceutics14061153.

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Drugs can be toxic to the fetus depending on the amount that permeates across the maternal–fetal barrier. One way to limit the amount which penetrates this barrier is to increase the molecular size of the drug. In this study, we have achieved this by encapsulating our model antibiotic (vancomycin hydrochloride, a known nephrotoxic agent) in liposomes. PEGylated and non-PEGylated liposomes encapsulating vancomycin hydrochloride were prepared using two different methods: thin-film hydration followed by the freeze–thaw method and the reverse-phase evaporation method. These liposomes were characte

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4

Barzago, M. M., A. Bortolotti, F. F. Stellari, et al. "Placental transfer of valproic acid after liposome encapsulation during in vitro human placenta perfusion." Journal of Pharmacology and Experimental Therapeutics 277, no. 1 (1996): 79–86. https://doi.org/10.1016/s0022-3565(25)12859-0.

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5

Bajoria, Rekha, Nicholas M. Fisk, and Soli F. Contractor. "Liposomal Thyroxine: A Noninvasive Model for Transplacental Fetal Therapy*." Journal of Clinical Endocrinology & Metabolism 82, no. 10 (1997): 3271–77. http://dx.doi.org/10.1210/jcem.82.10.4301.

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Abstract Drugs that cross the placenta sparingly are currently given directly to the fetus by invasive procedures. We investigated whether anionic small unilamellar (SUV) liposomes of different lipid compositions enhanced the transfer and uptake of T4 in an in vitro model of perfused human term placenta. T4-encapsulated anionic liposomes were prepared using lecithin (F-SUV) or distearoyl phosphatidylcholine (S-SUV) with cholesterol and dicetylcholine. The size distribution, encapsulation efficiency, and stability were determined in blood-based media. The transfer kinetics of free and liposomal

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6

Wang, Zengfang, Ruizhen Yang, Jiaojiao Zhang, et al. "Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance." Mediators of Inflammation 2021 (June 18, 2021): 1–10. http://dx.doi.org/10.1155/2021/5558048.

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Background. Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions through soluble factors to maintain normal placental development. Extracellular vesicles (EVs) are diverse nanosized to microsized membrane-bound particles released from various cells. EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. EV-

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7

Young, Sharon M., Laura K. Gryder, Winnie B. David, Yuanxin Teng, Shawn Gerstenberger, and Daniel C. Benyshek. "Human placenta processed for encapsulation contains modest concentrations of 14 trace minerals and elements." Nutrition Research 36, no. 8 (2016): 872–78. http://dx.doi.org/10.1016/j.nutres.2016.04.005.

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8

Young, Sharon M., Laura K. Gryder, David Zava, David W. Kimball, and Daniel C. Benyshek. "Presence and concentration of 17 hormones in human placenta processed for encapsulation and consumption." Placenta 43 (July 2016): 86–89. http://dx.doi.org/10.1016/j.placenta.2016.05.005.

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9

Yasin, Mursleen, Li Li, Michelle Donovan-Mak, Zhong-Hua Chen, and Sunil K. Panchal. "Capsicum Waste as a Sustainable Source of Capsaicinoids for Metabolic Diseases." Foods 12, no. 4 (2023): 907. http://dx.doi.org/10.3390/foods12040907.

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Capsaicinoids are pungent alkaloid compounds enriched with antioxidants, anti-microbial, anti-inflammatory, analgesics, anti-carcinogenic, anti-obesity and anti-diabetic properties. These compounds are primarily synthesised in the placenta of the fruit and then transported to other vegetative parts. Different varieties of capsicum and chillies contain different capsaicinoid concentrations. As capsicums and chillies are grown extensively throughout the world, their agricultural and horticultural production leads to significant amount of waste generation, in the form of fruits and plant biomass.

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10

Onur, M. A., I. Vural, n. Başçi, et al. "Effect of encapsulation of chloramphenicol in albumin microspheres on itsin vitrotransfer across the human placenta." Journal of Microencapsulation 11, no. 6 (1994): 657–62. http://dx.doi.org/10.3109/02652049409051116.

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11

Khalil, Fatma, Abdelrahman Alwan, Patrick Ralph, et al. "Effect of Alginate Microbead Encapsulation of Placental Mesenchymal Stem Cells on Their Immunomodulatory Function." Annals of Biomedical Engineering 50, no. 3 (2022): 291–302. http://dx.doi.org/10.1007/s10439-022-02920-5.

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12

Onur, M. A., C. J. Kirby, A. Isimer, et al. "Effect of liposomal encapsulation of chloramphenicol on its transfer across the human placenta in a dual in vitro perfusion system." International Journal of Pharmaceutics 88, no. 1-3 (1992): 313–17. http://dx.doi.org/10.1016/0378-5173(92)90329-z.

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13

Silini, Antonietta R., Valentina Spoldi, Silvia De Munari, et al. "Immunological and Differentiation Properties of Amniotic Cells Are Retained After Immobilization in Pectin Gel." Cell Transplantation 27, no. 1 (2018): 70–76. http://dx.doi.org/10.1177/0963689717738786.

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Mesenchymal stromal cells from the human amniotic membrane (i.e., human amniotic mesenchymal stromal cells [hAMSCs]) of term placenta are increasingly attracting attention for their applications in regenerative medicine. Osteochondral defects represent a major clinical problem with lifelong chronic pain and compromised quality of life. Great promise for osteochondral regeneration is held in hydrogel-based constructs that have a flexible composition and mimic the physiological structure of cartilage. Cell loading within a hydrogel represents an advantage for regenerative purposes, but the encap

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14

Lu, Lidan, Ximei Cai, Luqin Guo, et al. "Fabrication of Quercitrin Nano Micellar Delivery System and Its Therapeutic Effect on Unexplained Recurrent Abortion." Journal of Biomedical Nanotechnology 18, no. 5 (2022): 1449–59. http://dx.doi.org/10.1166/jbn.2022.3328.

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We prepared a quercitrin nano micellar delivery system in this study to evaluate its oral bioavailability. The optimal formulation of quercetin nano micelles was determined through an orthogonal test. Characteristics (size of particles-SOP, morphology, efficiency of encapsulation-EE and stability) and the therapeutic property of quercitrin nano micelles on unexplained recurrent abortion (URSA) were evaluated. The SOP of quercitrin nano micelles was 111.88±3.70 nm with an EE of 95.66±0.57. A substantially increased release rate of quercetin from the micellar system was observed in different dis

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15

Ono, Kenji, Junpei Sato, Hiromi Suzuki, and Makoto Sawada. "Distribution of Signal Peptides in Microvesicles from Activated Macrophage Cells." International Journal of Molecular Sciences 24, no. 15 (2023): 12131. http://dx.doi.org/10.3390/ijms241512131.

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Extracellular vesicles, such as microvesicles (LEV) and exosomes (SEV), play an important role in intercellular signaling by encapsulating functional molecules and delivering them to specific cells. Recent studies showed that signal peptides (SPs), which are derived from sequences at the N-terminal of newly synthesized proteins, exhibited biological activity in the extracellular fluid. We previously reported that SPs were secreted into the extracellular fluid via SEV; however, it remains unclear whether the release of SPs occurs via LEV. In the present study, we demonstrated that SP fragments

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16

Xu, Peng, Yeling Ma, Hongyu Wu, and Yan-Ling Wang. "Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy." Frontiers in Cell and Developmental Biology 9 (March 11, 2021). http://dx.doi.org/10.3389/fcell.2021.646326.

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In placental mammals, reproductive success, and maternal-fetal health substantially depend on a well-being placenta, the interface between the fetus and the mother. Disorders in placental cells are tightly associated with adverse pregnancy outcomes including preeclampsia (PE), fetal growth restriction, etc. MicroRNAs (miRNAs) represent small non-coding RNAs that regulate post-transcriptional gene expression and are integral to a wide range of healthy or diseased cellular proceedings. Numerous miRNAs have been detected in human placenta and increasing evidence is revealing their important roles

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17

Uppu, Praveen, Singh Aastha, A. Sivasanker Amrita, Rani Morla Asha, and SreeRaja Kumar R. "Protocol for a Systematic Review of Effectiveness of Human Placentophagia on Health Benefits among Post Partum Women." August 7, 2023. https://doi.org/10.5281/zenodo.8220696.

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Introduction: Placentophagy or Placentophagia is the culture where many species of mammals eat their own placenta. This practice is now growing in humans as well. There are various reasons for this practice but in general it helps in promoting stabilization, enhancement and recovery for the postpartum phase in the females. There are very less number of studies conducted to explore more about placentophagy concept in humans. Purpose/objective: To identify the effectiveness of ingesting human Placentophagia by human to manage post-partum health ailments. Methods: A systematic review on randomize

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18

Sadeghi, Mitra, Seyed Abdollah Hosseini, Shahabeddin Sarvi, et al. "Enhanced clindamycin delivery using chitosan-coated niosomes to prevent Toxoplasma gondii strain VEG in pregnant mice: an experimental study." Tropical Medicine and Health 52, no. 1 (2024). http://dx.doi.org/10.1186/s41182-024-00636-x.

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Abstract Background Congenital toxoplasmosis occurs when a pregnant woman becomes infected with Toxoplasma gondii (T. gondii) for the first time. Treatment typically involves antimicrobial medications, with spiramycin commonly used to prevent transmission. However, spiramycin's effectiveness is limited due to poor placental penetration. Clindamycin, another antibiotic, can cross the placenta but reaches the fetus at only half the maternal concentration. Encapsulating the drug in chitosan-coated niosomes (Cs-Nio) could enhance its effectiveness by targeting specific organs and ensuring sustaine

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19

Kametani, Yoshie, Ryoji Ito, Shino Ohshima, et al. "Construction of the systemic anticancer immune environment in tumour-bearing humanized mouse by using liposome-encapsulated anti-programmed death ligand 1 antibody-conjugated progesterone." Frontiers in Immunology 14 (July 10, 2023). http://dx.doi.org/10.3389/fimmu.2023.1173728.

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Immune checkpoint inhibitors highlight the importance of anticancer immunity. However, their clinical utility and safety are limited by the low response rates and adverse effects. We focused on progesterone (P4), a hormone produced by the placenta during pregnancy, because it has multiple biological activities related to anticancer and immune regulation effects. P4 has a reversible immune regulatory function distinct from that of the stress hormone cortisol, which may drive irreversible immune suppression that promotes T cell exhaustion and apoptosis in patients with cancer. Because the antica

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20

LOGUE, OMAR, Fakhri Mahdi, Heather Chapman, Eric Matthew George, and Gene Lee Bidwell. "A Biopolymer‐Stabilized VEGF Chimera is Maternally Sequestered and Prevents Placental Ischemia Induced Increases in Blood Pressure in the Reduced Uterine Perfusion Pressure Model of Preeclampsia." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.851.6.

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Preeclampsia (PE) is a form of gestational hypertension that complicates 3–5 % of pregnancies in the United States. The etiology of PE originates from abnormal remodeling of the maternal spiral arteries, creating an ischemic placenta that releases factors that drive the pathophysiology. One of these pathological factors, soluble fms‐like tyrosine kinase‐1 (sFlt‐1), causes angiogenic imbalance by sequestering vascular endothelial growth factor (VEGF), leading to endothelial dysfunction and the manifestation of hypertension in the gravid female. Therapies targeted to factors, including sFlt‐1, t

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21

Annemer, Saoussan, Amine Ez-zoubi, Yassine Ez zoubi, et al. "Optimization and antifungal efficacy against brown rot fungi of combined Salvia rosmarinus and Cedrus atlantica essential oils encapsulated in Gum Arabic." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-46858-7.

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AbstractThe stability, sensitivity, and volatility of essential oils are some of their most serious limitations, and nanoencapsulation has been considered one of the most effective techniques for solving these problems. This research aimed to investigate the incorporation of Salvia rosmarinus Speen and Cedrus atlantica Manetti (MEO) essential oil mixture in Gum Arabic (GA) and to evaluate nanoencapsulation’s ability to promote antifungal activity against two brown rot fungi responsible for wood decay Gloeophyllum trabeum and Poria placenta. The optimization of encapsulation efficiency was perf

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22

Taweechaipaisankul, Anukul, Nutthanit Thumrongsiri, Walailuk Chonniyom, et al. "Alginate-based Encapsulation of Porcine Placenta Extract: Preparation, Enteric Sustained Release, Biological Activities, and Stability." Food Hydrocolloids for Health, January 2025, 100194. https://doi.org/10.1016/j.fhfh.2024.100194.

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23

Li, Yuchen, Yanling Yu, Dejun Li, and Lei Li. "Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia." Journal of Assisted Reproduction and Genetics, March 27, 2024. http://dx.doi.org/10.1007/s10815-024-03104-x.

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Abstract Purpose Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in the development of PE. However, the mechanism underlying the role of maternal exosomes in trophoblast dysfunction regarding the development of PE is poorly understood. Methods Plasma exosomes from maternal peripheral blood were collected from pregnant women with PE and from those with normal pregnancy. Bioinformatics analysis was used to

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24

Zhao, Haoyi, Runqing Li, Hui Yu, et al. "Intrauterine Perfusion of Versatile Nanotherapeutics for Revolutionizing Sono‐Chemotherapeutic Treatment of Orthotopic Choriocarcinoma." Advanced Functional Materials, April 13, 2025. https://doi.org/10.1002/adfm.202422357.

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AbstractChoriocarcinoma (CC) is a malignant solid tumor caused by abnormal differentiation of placental trophoblast cells. Clinical treatment is mainly based on systemic intravenous chemotherapy, which faces multi therapeutic challenges. In this study, we pioneered the intrauterine perfusion route to treat orthotopic choriocarcinoma and achieved a precise targeting effect combined with sonodynamic therapy (SDT). Our research meticulously developed an innovative biomimetic drug delivery system, designated as HIC@M nanoparticles (HIC@M NPs). This system involved the incorporation of cisplatin (C

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25

Desai, Nina, Maribeth Spangler, Vaani Nanavaty, Arsela Gishto, and Alyssa Brown. "New hyaluronan-based biomatrix for 3-D follicle culture yields functionally competent oocytes." Reproductive Biology and Endocrinology 20, no. 1 (2022). http://dx.doi.org/10.1186/s12958-022-01019-9.

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Abstract Background Encapsulation of follicles within a biomatrix is one approach to maintaining 3-D follicle architecture during culture. Hyaluronan is one component of the natural extracellular matrix (ECM) that provides support to cells in vivo. This report describes the application of a novel tyramine-linked hyaluronan for 3-D in vitro follicle culture and the production of developmentally competent metaphase II oocytes. Materials and Methods Enzymatically isolated mouse preantral follicles or follicle clusters (FL-C) from fresh or vitrified ovaries were encapsulated in 3 mg/ml of hyaluron

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