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1
Filip, Palda K., ed. Provincial trade wars: Why the blockade must end. The Fraser Institute, 1994.
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2
Blockade of Phalsburg: An Episode of the End of the Empire. Creative Media Partners, LLC, 2023.
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3
Erckmann, Emile. Blockade of Phalsburg: An Episode of the End of the Empire. Creative Media Partners, LLC, 2018.
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4
Erckmann-Chatrian. The Blockade of Phalsburg: An Episode of the End of the Empire. Kessinger Publishing, 2005.
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5
Erckmann-Chatrian. The Blockade of Phalsburg An Episode of the End of the Empire. Kessinger Publishing, LLC, 2007.
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6
Hunter, Jennifer M., and Thomas Fuchs-Buder. Neuromuscular blockade and reversal. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0016.
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Over the past 70 years since the introduction of d-tubocurarine, the search for an ideal neuromuscular blocking agent has led to the development of the depolarizing drug, succinylcholine (suxamethonium), with its rapid onset of action and plasma metabolism, and a series of non-depolarizing agents of which there are two groups: benzylisoquinoliniums (e.g. atracurium, cisatracurium and mivacurium) and aminosteroidal agents (e.g. pancuronium, vecuronium and rocuronium). The need to monitor neuromuscular block perioperatively to ensure the appropriate dose of any neuromuscular blocking drug is given has led to the development of several nerve stimulation techniques. Particularly useful clinically are the train-of-four twitch response, double-burst stimulation, and the post-tetanic count. Their benefits and limitations are considered in this chapter. The most suitable equipment to monitor neuromuscular block and the appropriate anatomical sites for stimulation are discussed. To prevent residual block with its pathophysiological consequences such as upper airway and pharyngeal dysfunction and potential respiratory failure at the end of surgery, antagonizing agents are used. These are of two types: anticholinesterases such as neostigmine and edrophonium, and the γ-cyclodextrin, sugammadex. The pharmacodynamics and pharmacokinetics of neuromuscular blocking drugs and their antagonists are altered by the extremes of age, obesity, and several disease states including renal and hepatic failure, neuromuscular disorders, and critical illness. The altered response to all these drugs in these pathologies, which is related to their metabolism and excretion, is considered in detail, together with their other side-effects including the particular disadvantages to the use of succinylcholine.
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Kreit, John W. Acute Respiratory Distress Syndrome (ARDS). Edited by John W. Kreit. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190670085.003.0012.
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Acute Respiratory Distress Syndrome reviews the definitions, causes, pathophysiology, and management of this relatively common, life-threatening disorder. This chapter describes how to ensure adequate tissue oxygen delivery while minimizing ventilator-induced lung injury and provides an in-depth review of how to determine the optimum level of positive end-expiratory pressure (PEEP). The first topic addressed is the precipitating factors and pathophysiology of acute respiratory distress syndrome. Next the chapter turns to mechanical ventilation, and covers the subjects of adequate oxygenation, ventilator-induced lung injury, ancillary therapies, ventilatory therapies, and high I:E ventilation. The topics addressed in the area of non-ventilatory therapies include: prone positioning of the patient, neuromuscular blockade, inhaled vasodilators, and extracorporeal membrane oxygenation (ECMO).
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Levy, David. Management of microvascular and associated complications. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198766452.003.0007.
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While end-stage microvascular complications are now relatively uncommon, the burden of microvascular disease is still heavy. National diabetic retinopathy screening programmes have contributed to reducing advanced retinal disease, as has improved laser technology and vitreoretinal surgery. More recently intravitreal anti-VEGF agents (bevacizumab, ranibizumab, and aflibercept) have been effective in reducing visual loss from macular oedema. Diabetic nephropathy has a variable phenotype, and high rates of natural regression from microalbuminuria to normoalbuminuria mandate careful and regular review with regular urinary albumin-creatinine ratio (ACR) measurements. Up to one-quarter of patients with renal impairment have never had microalbuminuria. Long-term glycaemic control is the most important treatment for early diabetic nephropathy; angiotensin blockade treatment (ACE-inhibitors, angiotensin receptor blockers) are less important. In established diabetic nephropathy, intensive multimodal treatment is needed. Neuropathic complications are usually plantar ulceration, Charcot neuroarthropathy, and autonomic, especially gastroparesis and erectile dysfunction.
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Sliwa, Karen, and Denise Hilfiker-Kleiner. Peripartum cardiomyopathy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0374.
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Pregnancy-related heart disease is increasing worldwide and peripartum cardiomyopathy (PPCM) is an important contributor to early (<42 days postpartum) and late (up to 1 year postpartum) maternal death. PPCM is an idiopathic form of cardiomyopathy, presenting with heart failure secondary to left ventricular dysfunction towards the end of pregnancy, or in the months following delivery, where no other cause of heart failure is identified. It is a diagnosis of exclusion. Incidence and prognosis varies according to geography and is likely due to multiple factors. The recent specific pathophysiological hypothesis which states that the oxidative stress–cathepsin D-16 kDa prolactin cascade plays a key role in the development of PPCM in experimental models and in humans suggests that a therapeutic approach involving blockade of this pathway with bromocriptine may be a novel disease-specific approach. Despite ongoing research, numerous uncertainties regarding the incidence, pathophysiology, treatment, and prognosis of PPCM patients remain, indicating the need for further investigation. The establishment of the international registry on PPCM, under the umbrella of the EuroObservational research programme, will provide novel information and address many uncertainties.
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Roberts, Priscilla, ed. Cold War. ABC-CLIO, 2018. http://dx.doi.org/10.5040/9798216961840.
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This detailed two-volume set tells the story of the Cold War, the dominant international event of the second half of the 20th century, through a diverse selection of primary source documents. One of the most extensive to date, this set of primary source documents studies the Cold War comprehensively from its beginning, with the emergence of the world's first communist government in Russia in late 1917, to its end, in 1991. All of the key events, including the Berlin Blockade, the Korean War, the Cuban Missile Crisis, the Vietnam War, and the nuclear arms race, are discussed in detail. The primary sources provide insight into the thinking of all participants, drawing on Western, Soviet, Asian, and Latin American perspectives. InThe Cold War: Interpreting Conflict through Primary Documentsprimary documents are organized chronologically, allowing readers to appreciate the ramifications of the Cold War within a clear time frame. Extensive interpretive commentary provides in-depth background and context for each document. This work is an indispensable reference for all readers seeking to become deeply knowledgeable about the Cold War.
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Roberts, Priscilla, ed. Cold War. ABC-CLIO, 2018. http://dx.doi.org/10.5040/9798216961833.
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This detailed two-volume set tells the story of the Cold War, the dominant international event of the second half of the 20th century, through a diverse selection of primary source documents. One of the most extensive to date, this set of primary source documents studies the Cold War comprehensively from its beginning, with the emergence of the world's first communist government in Russia in late 1917, to its end, in 1991. All of the key events, including the Berlin Blockade, the Korean War, the Cuban Missile Crisis, the Vietnam War, and the nuclear arms race, are discussed in detail. The primary sources provide insight into the thinking of all participants, drawing on Western, Soviet, Asian, and Latin American perspectives. InThe Cold War: Interpreting Conflict through Primary Documentsprimary documents are organized chronologically, allowing readers to appreciate the ramifications of the Cold War within a clear time frame. Extensive interpretive commentary provides in-depth background and context for each document. This work is an indispensable reference for all readers seeking to become deeply knowledgeable about the Cold War.
12
Levy, David M., and Ieva Saule. General anaesthesia for caesarean delivery. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0022.
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General anaesthesia (GA) is most often indicated for category 1 (immediate threat to life of mother or baby) caesarean delivery (CD) or when neuraxial anaesthesia has failed or is contraindicated. Secure intravenous access is essential. Jugular venous cannulation (with ultrasound guidance) is required if peripheral access is inadequate. A World Health Organization surgical safety checklist must be used. The shoulders and upper back should be ramped. Left lateral table tilt or other means of uterine displacement are essential to minimize aortocaval compression, and a head-up position is recommended to improve the efficiency of preoxygenation and reduce the likelihood of gastric contents reaching the oropharynx. Cricoid pressure is controversial. In the United Kingdom, thiopental remains the induction agent of choice, although there is scant evidence upon which to avoid propofol. In pre-eclampsia, it is essential to obtund the pressor response to laryngoscopy with remifentanil or alfentanil. Rocuronium is an acceptable alternative to succinylcholine for neuromuscular blockade. Sugammadex offers the possibility of swifter reversal of rocuronium than spontaneous recovery from succinylcholine. Management of difficult tracheal intubation is focused on ‘oxygenation without aspiration’ and prevention of airway trauma. The Classic™ laryngeal mask airway is the most commonly used rescue airway in the United Kingdom. There is a large set of data from fasted women of low body mass index who have undergone elective CD safely with a Proseal™ or Supreme™ laryngeal mask airway. Sevoflurane is the most popular volatile agent for maintenance of GA. The role of electroencephalography-based depth of anaesthesia monitors at CD remains to be established. Intraoperative end-tidal carbon dioxide tension should be maintained below 4.0 kPa.
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Hwang, Young-Hwan, and York Pei. Autosomal dominant polycystic kidney disease management. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0309_update_001.
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Management of patients with autosomal dominant polycystic kidney disease (ADPKD) currently comprises non-specific measures including promotion of healthy lifestyle, optimization of blood pressure control, and modification of cardiovascular risk factors. A high water intake of 3–4 L per day in patients with glomerular filtration rate greater than 30 mL/min/1.73 m2 may decrease the risk of kidney stones, but its potential benefit in reducing renal cyst growth is presently unproven. Maintenance of a target blood pressure of 130/80 mmHg is recommended by expert clinical guidelines though this is unlikely to slow cyst growth. It is unclear whether pharmacological blockade of the renin–angiotensin axis confers an extrarenal protective effect. Recognition of the variable clinical presentations of cyst infection, cyst haemorrhage, or nephrolithiasis is important for early diagnosis and optimal management of these complications. Most patients with ADPKD do well on dialysis and after transplantation. Nephrectomy may be needed to make space for a donor kidney, or if kidney size or infection is an issue after end-stage renal failure is reached. Recent advances in ADPKD have led to the identification of multiple potential therapeutic targets with more than 10 clinical trials completed or currently in progress. Given the promising results of the TEMPO trial, tolvaptan may well be the first disease-modifying drug to be approved for clinical use. Several other classes of drugs (e.g. somatostatin analogues, triptolide, metformin, and glucosylceramide synthase inhibitors) with good long-term safety profiles are promising candidates which may be repurposed for this disease. In the future, identifying patients with different risks of renal disease progression by their genotype and/or kidney volume will likely assume an important role for the clinical management of ADPKD.
14
Watson, Bruce A. Atlantic Convoys and Nazi Raiders. Greenwood Publishing Group, Inc., 2005. http://dx.doi.org/10.5040/9798400615658.
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In November of 1940, the German pocket battleship Admiral Scheer attacked British Convoy HX-84. The merchant cruiser HMS Jervis Bay, a converted passenger liner that was the convoy's only escort—armed only with antique 6-inch guns—charged the Nazi raider. While the Jervis Bay did not stand a chance of surviving the battle, her crew's fatalistic bravery inspired awe in all who witnessed the fight. Watson recounts how the Scheer's 11-inch guns turned the ship into a burning hulk in twenty-two minutes, but most of the convoy escaped. In November of 1940, the German pocket battleship Admiral Scheer attacked British Convoy HX-84. The Armed Merchant Cruiser HMS Jervis Bay, the only escort and mounting antique 6-inch guns, charged the Nazi raider. While the Jervis Bay did not stand a chance of surviving the battle, her crew's fatalistic bravery inspired awe in all who witnessed the fight. Watson describes how the Scheer's 11-inch guns turned the converted passenger liner into a burning hulk in twenty-two minutes, but most of the convoy escaped. How did this confrontation come to pass? Both the necessity of arming a passenger liner and pretending it was a warship, and the building of the Admiral Scheer and her sister ships for the express purpose of commerce raiding, find their roots in the events, political decisions, re-armament polices, war plans, naval traditions, and blunders that arose in pre-war Britain and Germany. But this event holds a significance beyond the battle itself. The sinking of the Jervis Bay symbolizes the end of an era in naval warfare. The Armed Merchant Cruisers of the Second World War inherited a long, sometimes noble and sometimes ignoble history. Long employed in blockade or patrol duty, armed merchant cruisers ventured out for the first time to escort convoys, a defensive duty for which they were eminently unsuited, and for which the Jervis Bay paid a fearful price.
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Ferro, Charles J., and Khai Ping Ng. Recommendations for management of high renal risk chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0099.
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Poorer renal function is associated with increasing morbidity and mortality. In the wider population this is mainly as a consequence of cardiovascular disease. Renal patients are more likely to progress to end-stage renal disease, but also have high cardiovascular risk. Aiming to reduce both progression of renal impairment and cardiovascular disease are not contradictory. Focusing on the management of high-risk patients with proteinuria and reduced glomerular filtration rates, it is recommended that blood pressure should be kept below 140/90, or 130/80 if proteinuria is > 1 g/24 h (protein:creatinine ratio (PCR) >100 mg/mmol or 0.9 g/g). These targets may be modified according to age and other factors. Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor antagonists should form part of the therapy for patients with proteinuria > 0.5 g/24 h (PCR > 50 mg/mmol or 0.45 g/g). Use of ACEIs or angiotensin receptor blockers in patients with lower levels of proteinuria may be indicated in some patient groups even in the absence of hypertension, notably in diabetic nephropathy. Evidence that other agents that reduce proteinuria bring additional benefits is weak at present. The best studies of ‘dual-blockade’ with various combinations of ACEIs, ARBs, and renin inhibitors have shown additional hazard with little evidence of additional benefit. Hyperlipidaemia—regardless of lipid levels, statin therapy is indicated in secondary cardiovascular prevention, and in primary prevention where cardiovascular risk is high, noting that current risk estimation tools do not adequately account for the increased risk of patients with CKD. There is not substantial evidence that lipid lowering therapy impacts on average rates of loss of GFR in progressive CKD. Non-drug lifestyle interventions to reduce cardiovascular risk, including stopping smoking, are important for all. Acidosis—in more advanced CKD it is justified to treat acidosis with oral sodium bicarbonate. Diet—sodium restriction to < 100 mmol/day (6 g/day) and avoidance of excessive dietary protein are justified in early to moderate CKD. Recommendations to limit levels of protein to 0.8 g/kg body weight are suggested by some, but additional protective effects of this are likely to be slight in patients who are otherwise well managed. Low-protein diets may carry some risk. Lower-protein diets may however be used to prevent symptoms in advanced CKD not treated by dialysis.
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Marques, Tiago Reis, and Shitij Kapur. Novel Approaches for Treating Psychotic Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0021.
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Current antipsychotic medications have been the mainstay in the treatment of schizophrenia since chlorpromazine was introduced in 1952. However, all antipsychotics share the same mechanism of action, which involves a blockade of the dopamine D2-receptor. This chapter covers recent attempts to develop new treatments for psychotic disorders. These include new approaches to the delivery of existing antipsychotic medications and the most recent and promising mechanisms of action that are distinct from existing antipsychotics. Some of the new mechanisms of action include drugs targeting the glutamatergic system, the alpha7 nicotinic acetylcholine receptor, the phosphodiesterase 10A enzyme, or the muscarinic and serotoninergic system. Finally, we have reviewed a number of alternative nonpharmacological pathways, such as avatar therapy, repetitive transcranial magnetic stimulation, or cognitive remediation. The chapter ends by discussing some of the major challenges facing the development of new treatments for psychotic disorders.
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Foss, Colin. The Culture of War. Liverpool University Press, 2020. http://dx.doi.org/10.3828/liverpool/9781789621921.001.0001.
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The Culture of War explores the unexpected flourishing of literature both high and low during the Siege of Paris at the end of the Franco-Prussian War, 1870-1871. When Prussian forces completely blockaded Paris, isolating the city from the outside world, Parisians turned to literature to resist the enemy, to fill the idle hours under siege, and to articulate their place in history. This cultural boom was a conscious effort on the part of literary institutions like newspapers, publishers, and theaters to ensure the viability of their industries during a period of political uncertainty. To do so, many publishers, editors, and directors sought legitimacy through populism, promoting literature written by anonymous and unknown authors or that spoke to populist ideas. A study of national tragedy on a local scale, The Culture of War goes beyond traditional narratives of communal or individual psychology, and studies institutional responses to financial and political instability, viewing literature as a product of economic and political forces.
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Lichtenstein, Nelson. From Corporatism to Collective Bargaining. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252037856.003.0007.
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This chapter discusses the emergence increasingly privatized system of collective bargaining after the end of World War II. The turning point came between 1946 and 1948 when a still powerful trade union movement found its efforts to bargain over the shape of the postwar political economy decisively blocked by a powerful remobilization of business and conservative forces. Labor's ambitions were thereafter sharply curbed, and its economic program was reduced to a sort of militant-interest-group politics, in which a Keynesian emphasis on sustained growth and productivity gain sharing replaced labor's earlier commitment to economic planning and social solidarity. This forced retreat narrowed the political appeal of labor-liberalism and contributed both to the demobilization and division of those social forces that had long sustained it.
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Coremagik and Luci Fae Davies. Soul Wisdom for Better Relationships and Journal: Know More about Sexuality, Eros, and Love Discover the Blockages, End the Toxic Relationship Cycle to Live in Harmony with Your Loved One. CoreMagik, 2023.
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Government, U. S., U. S. Air Force (USAF), U. S. Military, and Department of Defense. To Save a City: The Berlin Airlift 1948-1949 - Germany in Defeat after World War II, Marshall Plan, Pretext for Soviet Action, Global Logistics, Operation Vittles, Blockade Ends As Airlift Wins, NATO. Independently Published, 2017.
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21
Salje, Léa. Saying What One Thinks. Oxford University PressOxford, 2025. https://doi.org/10.1093/9780198914211.001.0001.
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Abstract Saying what one thinks can be difficult; sometimes one knows that a thought is there, but it takes time and effort to find its proper articulation. This book is about articulatory self-knowledge, or the sort of knowledge about one’s own mind that results from successful attempts to articulate evasive thoughts of this kind. Rather than account for this phenomenon as a mere verbal blockage, this book argues that the obstacle to articulation in these cases has to do with the representational metaphysics of the thought. When it first occurs, the thought has the wrong representational format to serve as the content of a sentence—work must be done on it before it can be uttered aloud. What results is a picture of a little-explored form of psychological self-knowledge that reveals hidden parts of one’s mind to oneself even as one goes about creating the thought in its new, articulated form. The final parts of the book explore the role of conversation in drawing out articulations of this kind, and the possible expression of thoughts in art. By the end of the book, articulatory self-knowledge no longer looks like a mere quirk of our psychology, but emerges as a central feature of distinctively human cognition.
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Buttar, Prit. Hero City. Bloomsbury Publishing Plc, 2024. https://doi.org/10.5040/9781472856630.
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One of the greatest ever sieges is masterfully brought to life by a leading expert on the Eastern Front. At the height of World War II the people of Leningrad endured a bitter 900-day siege, struggling against bombing, shelling, and starvation. Prit Buttar tells the story of how the siege was finally broken. The Red Army had suffered multiple setbacks in the preceding two years but achieved a partial success by breaking the blockage in early 1943. However, this was followed by further failed attempts to lift the siege completely. But by simply enduring the siege in the face of impossible odds, Russian soldiers and civilians beat the Germans. By the end of 1943 the German forces, themselves broken by deprivations and extreme weather, began to pull back. Here was the opportunity the Soviet forces had been waiting for. The Red Army launched a decisive attack that broke through and ended the siege. Their determination to hold out has become a hugely significant part of Russian history, the echoes of the battle helping to define both a country and its politics. This compelling history uses original Russian source material to vividly describe the deprivations visited upon those trapped. But it also details the tactical successes and strategic failures of both sides as well as the appalling war crimes that have forever stained the ground in and around this historic city.
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Lee, Olivia T., Jennifer N. Wu, Frederick J. Meyers, and Christopher P. Evans. Genitourinary aspects of palliative care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0084.
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Genitourinary tract diseases in the palliative care setting most commonly involve urinary tract obstruction, intractable bleeding, fistulae, and bladder-associated pain. Sources of obstruction in the lower urinary tract include benign prostatic hyperplasia, invasive prostate or bladder cancer, urethral stricture, or bladder neck contracture. Upper tract obstruction includes intraluminal or extraluminal blockage of the renal collecting system and ureters, such as transitional cell carcinoma, fibroepithelial polyps, stricture, stones, pelvic or retroperitoneal malignancy, fibrosis, or prior radiation. Untreated, obstructive uropathy leads to elevated bladder, ureter, and kidney pressures, bladder dysfunction, urolithiasis, renal failure, pyelonephritis, or urosepsis. Intractable haematuria can cause problematic anaemia, frequent transfusions, clot retention, haemorrhagic shock, and death. In addition, urinary tract fistulae such as vesicovaginal and vesicoenteric fistulae are common in patients who have had prior pelvic surgery or radiation especially in the setting of immunocompromise, poor nutrition, and infection. Untreated, these symptoms lead to rash, skin breakdown, ulcers, chronic infection, and sepsis. Lastly, pelvic and bladder pain, depending on aetiology can be treated with oral medications, intravesical therapies, or surgical therapies such as palliative resection or urinary diversion. Selection of tests and treatment modalities in the palliative care setting should be based on using the least invasive means to achieve the most relief in suffering. Some genitourinary conditions are potentially fatal, and in the acute or subacute setting, require re-evaluation of the end-of-life goals and wishes of the patient and family.
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Rhode, Deborah L. Ambition. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197538333.001.0001.
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Ambition is a dominant force in human civilization, driving its greatest achievements and most horrific abuses. Our striving has brought art, airplanes, and antibiotics, as well as wars, genocide, and despotism. This mixed record raises obvious concerns about how we can channel ambition in the most productive directions. To that end, the book begins by exploring three central focuses of ambition: recognition, power, and money. It argues that an excessive preoccupation with these external markers for success can be self-defeating for individuals and toxic for society. Discussion then shifts to the obstacles to constructive ambition and the consequences when ambitions are skewed or blocked by inequality and identity-related characteristics such as gender, race, class, and national origin. Attention also centers on the ways that families, schools, and colleges might play a more effective role in developing positive ambition. The book concludes with an exploration of what sorts of ambitions contribute to sustained well-being. Contemporary research makes clear that even from a purely self-interested perspective, individuals would do well to strive for some goals that transcend the self. Pursuing objectives that have intrinsic value, such as building relationships and contributing to society, generally brings greater fulfillment than chasing extrinsic rewards such as wealth, power, and fame. And society benefits when ambitions for self-advancement do not crowd out efforts for the common good. The hope is to prompt readers to reconsider where their ambitions are leading and whether that destination reflects their deepest needs and highest aspirations.