Log in

Relevant bibliographies by topics / End of Treatment Response / Dissertations / Theses

To see the other types of publications on this topic, follow the link: End of Treatment Response.

Dissertations / Theses on the topic 'End of Treatment Response'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'End of Treatment Response.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Rarick, Kevin Richard. "Cardiovascular end-organ damage in response to increased blood pressure variability : impact of oxidative stress." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3370.

Full text

Abstract:

Baroreflex sensitivity (BRS) is often reduced in elderly populations and patients with chronic cardiovascular diseases leading to a concomitant rise in blood pressure variability (BPV) that is associated with increased cardiovascular related morbidity and mortality. Thus, there is a need to better understand the mechanisms by which BPV causes cardiovascular end-organ damage. Animal studies using sinoaortic denervation (SAD) to increase BPV have demonstrated pathologic changes in the structure of the heart and blood vessels; however, there is a paucity of data investigating changes in functiona

APA, Harvard, Vancouver, ISO, and other styles

2

Matthiasson, Páll. "Dealing with treatment resistance to clozapine : characteristics of treatment response in schizophrenia." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/dealing-with-treatment-resistance-to-clozapine--characteristics-of-treatment-response-in-schizophrenia(f43c968b-8789-44e7-9161-3cab811ee429).html.

Full text

Abstract:

Background: Clozapine, the treatment of choice in treatment-resistant schizophrenia, is not effective in up to half of patients. Aims of this thesis were: to verify whether clozapine augmentation with amisulpride, an atypical antipsychotic with preferential affinity at doparninergic D2-like receptors, is clinically effective; to test the prediction that changes in D2-like receptor availability might explain that improvement; to explore clinical and receptor availability characteristics of good clozapine responders. Methods: Study 1: Thirty-three patients with schizophrenia, partially or non-re

APA, Harvard, Vancouver, ISO, and other styles

3

Mirza, Ahmad. "Markers of treatment response for gastro-oesophageal cancers." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/markers-of-treatment-response-for-gastrooesophageal-cancers(c53c4845-7120-4490-831d-c27bfc823a93).html.

Full text

Abstract:

Introduction: The incidence of gastro-oesophageal cancers has increased considerably over the last decade. As the disease is associated with a poor prognosis, there is a need to identify markers of treatment response which could be used in the future to improve the management of gastro-oesophageal tumours. Aims: 1) To compare the ability of published histological grading criteria (Becker, Mandard and Ninomiya) to assess response to neo-adjuvant chemotherapy (NCT) in gastro-oesophageal cancers. 2) To evaluate the expression of thymidylate synthase (TS) in pre-treatment diagnostic biopsy samples

APA, Harvard, Vancouver, ISO, and other styles

4

Goozee, Rhianna Mae. "The neurobiological basis of treatment response in psychosis." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/the-neurobiological-basis-of-treatment-response-in-psychosis(227079ee-19b1-46e5-b8a7-121118d665a3).html.

Full text

Abstract:

Antipsychotic treatment response is unpredictable and variable, and there are currently no reliable neurobiological assessment methods to predict treatment efficacy. Previous research suggests that psychosis is associated with several brain abnormalities and that some of these may be associated with poorer treatment response. This thesis investigated the association between brain function (salience attribution during fMRI and perfusion) and treatment response at 4 and 12 weeks in antipsychotic-naïve patients with their first episode of psychosis. Twenty-five first episode psychosis patients to

APA, Harvard, Vancouver, ISO, and other styles

5

Wu, Chang Kai. "Predicting the Response of Aluminum Casting Alloys to Heat Treatment." Digital WPI, 2012. https://digitalcommons.wpi.edu/etd-dissertations/117.

Full text

Abstract:

The objective of this research was to develop and verify a mathematical model and the necessary material database that allow predicting the physical and material property changes that occur in aluminum casting alloys in response to precipitation-hardening heat treatment. The model accounts for all three steps of the typical precipitation hardening heat treatment; i.e., the solutionizing, quenching, and aging steps; and it allows predicting the local hardness and tensile strength, and the local residual stresses, distortion and dimensional changes that develop in the cast component during each

APA, Harvard, Vancouver, ISO, and other styles

6

Lewis, Kristin N. "Trajectories of Headache Disability Treatment Response: Psychosocial and Clinical Correlates." Ohio : Ohio University, 2009. http://www.ohiolink.edu/etd/view.cgi?ohiou1266512215.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Warke, Virendra S. "Predicting the response of powder metallurgy steel components to heat treatment." Worcester, Mass. : Worcester Polytechnic Institute, 2008. http://www.wpi.edu/Pubs/ETD/Available/etd-072808-100705/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Strawbridge, Rebecca Clare. "Biomarkers of inflammation as predictors of treatment response in depression." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-inflammation-as-predictors-of-treatment-response-in-depression(0b70b627-0c8b-462b-9868-7c99ceb000ff).html.

Full text

Abstract:

People suffering with depression often do not respond sufficiently to current treatments. A wealth of research suggests that mood disorders are associated with higher levels of inflammation, yet this literature currently provides an inadequate description of the nature of the depressive disorders studied and involves extensive heterogeneity between patients and study methodologies. This thesis comprises three studies examining a broad spectrum of circulating pro-inflammatory proteins before and after interventions for depression, to test specific hypotheses that raised inflammatory markers pre

APA, Harvard, Vancouver, ISO, and other styles

9

Wang, Silas Lancelot. "Clinical characteristics and treatment response to radiotherapy of optic nerve sheath meningiomas." [New Haven, Conn. : s.n.], 2007. http://ymtdl.med.yale.edu/theses/available/etd-08282007-150948/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Capua, Christopher James. "Comparative Cytotoxicity of an FDA-approved Cancer Drug to Extracts of Atriplex confertifolia on Human Breast and Cervical Cancer Cells." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1703.

Full text

Abstract:

The severity and number of people affected by cancer is a worldwide problem with millions of people affected annually. The search for treatment and cures of cancer continues to be a global effort. As part of this global effort, many natural products have been tested against cancer cell lines, most from plants located in tropical regions. However, this study reports that extracts of Atriplex confertifolia, a native North American plant, has significant bioactivity against human breast cancer cell lines MCF-7, 435, and 231, and HeLa cells (cervical cancer cells). The bioactivity of A. confertifo

APA, Harvard, Vancouver, ISO, and other styles

11

Selles, Robert Rein. "Treatment Maintenance of Cognitive-Behavioral Therapy for Anxiety in Youth with Autism Spectrum Disorders." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4843.

Full text

Abstract:

Anxiety disorders commonly co-occur in children and adolescents with an autism spectrum disorder (ASD). Recently, treatment of anxiety using cognitive behavioral therapy (CBT) has been modified and studied in youth with ASD, with results consistently demonstrating positive treatment outcomes. In typically developing populations, CBT gains are well maintained as long as 14-years post-treatment; however, maintenance of CBT has not yet been studied in anxious youth with ASD. Using a sample of 32 youth who previously completed one of three CBT for anxiety in ASD treatment studies, the present stu

APA, Harvard, Vancouver, ISO, and other styles

12

McClurg, Sarah Elizabeth. "Stream ecosystem response to mitigative limestone treatment in acid impaired, central Appalachian streams." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3667.

Full text

Abstract:

Thesis (M.S.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains ix, 104 p. : ill., maps. Includes abstract. Includes bibliographical references (p. 41-49).

APA, Harvard, Vancouver, ISO, and other styles

13

Johnson, Craig Douglas. "Community Response to False Hellebore (Veratrum californicum Durand) Harvest 18 Years after Treatment." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2566.

Full text

Abstract:

Discoveries revolving around false hellebore (Veratrum californicum Durand) have caused a paradigm shift in treatment from eradication to harvest and preservation. Test plots set in place 18 years ago to analyze the effectiveness of eradication treatments (tilling, herbicide, mow, and remow) give us a better idea of how false hellebore communities might respond to disturbances caused by harvest. We focused mainly on the tilling, mow, and remow treatments because of similarities to harvest techniques.We found that mow and remow treatments have little effect on the population of false hellebore

APA, Harvard, Vancouver, ISO, and other styles

14

Kurtyka, Donald E. "The Effects of a Structured Adherence Intervention to HAART on Adherence and Treatment Response Outcomes." Scholar Commons, 2007. https://scholarcommons.usf.edu/etd/350.

Full text

Abstract:

Background: Adherence to antiretroviral (ARV) medications in excess of 90-95% is necessary for optimal response to suppress HIV replication and to maintain and/or restore immune function. A number of interventions have been shown to improve ARV adherence, but no research has been conducted which evaluates proactive monitoring of pharmacy refill adherence and subsequent intervention when inadequate adherence is identified. Purpose: The purpose of this project was to compare treatment response, pharmacy refill adherence and self-reported medication adherence between two groups of patients: those

APA, Harvard, Vancouver, ISO, and other styles

15

Pawley, Adam David. "Novel TMS and EEG markers of diagnosis and treatment response in epilepsy." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/novel-tms-and-eeg-markers-of-diagnosis-and-treatment-response-in-epilepsy(02e6922a-e038-41af-bac9-169770fb7d05).html.

Full text

Abstract:

Approximately 30% of epilepsy patients do not respond to treatment, whereas others attain seizure freedom with the same medication, the reasons remain unclear. Previous work utilised transcranial magnetic stimulation (TMS) to reveal predictive markers of treatment response in new-onset drug-naïve patients, distinguishing good responders from those who become intractable. I hypothesised that these markers should also be present in long-term treatment resistant epilepsy, allowing outcome prediction in patients commencing new medications. A central hypothesis in this thesis is that, interictal br

APA, Harvard, Vancouver, ISO, and other styles

16

Mumford, Karen Rose. "The Stress Response, Psychoeducational Interventions and Assisted Reproduction Technology Treatment Outcomes: A Meta-Analytic Review." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000495.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Stringham, Roger Blair. "Greater Sage-Grouse Response to Sagebrush Reduction Treatments in Rich County, Utah." DigitalCommons@USU, 2010. https://digitalcommons.usu.edu/etd/693.

Full text

Abstract:

Management of greater sage-grouse (Centrocercus urophasianus) in the west has changed over the last several decades in response to environmental and anthropogenic causes. Many land and wildlife management agencies have begun manipulating sagebrush with herbicides, machinery, and fire. The intent of these manipulations (treatments) is to reduce sagebrush canopy cover and increase the density of grass and forb species, thus providing higher quality sage-grouse brood-rearing habitat. However, monitoring of sage-grouse response to such manipulations has often been lacking or non-existent. The obje

APA, Harvard, Vancouver, ISO, and other styles

18

Merritt, Kate Sky. "Glutamate dysfunction in first episode psychosis and relationship with the response to treatment." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/glutamate-dysfunction-in-first-episode-psychosis-and-relationship-with-the-response-to-treatment(082da8ec-6d0b-49d6-87fa-e03939e92ac8).html.

Full text

Abstract:

Abnormal glutamatergic neurotransmission is strongly implicated in the pathophysiology of schizophrenia. The main technique available for assessing central glutamate function in man in vivo is proton magnetic resonance spectroscopy (1H-MRS), which can be used to measure glutamate, its metabolite glutamine, or their combination (Glx). Although around sixty 1H-MRS studies in schizophrenia have been published, the findings have been inconsistent, and the extent to which these vary with the brain region examined, the stage of the disorder, the severity of symptoms and the effects of treatment is u

APA, Harvard, Vancouver, ISO, and other styles

19

Mulhearn, Ben. "Identifying immune biomarkers to predict treatment response to biologic drugs in rheumatoid arthritis." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/identifying-immune-biomarkers-to-predict-treatment-response-to-biologic-drugs-in-rheumatoid-arthritis(c311fc8c-4239-444a-9912-ddd4fde5f7fa).html.

Full text

Abstract:

Rheumatoid arthritis (RA) is a chronic, heterogeneous, autoimmune disease that causes inflammation of synovial joints leading to pain, stiffness and swelling. If left untreated, RA results in irreversible joint destruction and long term disability. Initial treatment with glucocorticoids and other immunosuppressive agents suppresses inflammation. However, many of these drugs are not well-tolerated due to extensive side effects or are simply ineffective. The discovery of tumour necrosis factor-α (TNF) as a key mediator of inflammation in RA led to the development of monoclonal anti-TNF antibody

APA, Harvard, Vancouver, ISO, and other styles

20

Webster, Amy Philomena. "Epigenetics of response to biologic drug therapy in rheumatoid arthritis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/epigenetics-of-response-to-biologic-drug-therapy-in-rheumatoid-arthritis(d1518a5c-ef1c-4d8f-b210-8a2342139a45).html.

Full text

Abstract:

Background: Rheumatoid arthritis (RA) is a common complex autoimmune disorder which is influenced by both genetic and environmental factors. While multiple factors that influence susceptibility to and outcome of disease have been identified there is still a large proportion of missing heritability and limited understanding of disease pathogenesis. In recent years, biologic drug therapies have advanced treatment of RA; however good disease control is achieved in just 30% of patients, making identification of predictors of treatment response important. One area of research which is yet to be exp

APA, Harvard, Vancouver, ISO, and other styles

21

Lowe, Andrea S. "Neural Mechanisms of Transcranial Magnetic Stimulation in the Treatment of Tinnitus." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7637.

Full text

Abstract:

Millions of people suffer from tinnitus, a disorder for which there is currently no effective treatment or cure. My dissertation work provides insight into the neural correlates of this pervasive hearing disorder and examines how a newly emerging therapy, transcranial magnetic stimulation (TMS), affects the central auditory system in the generation of the tinnitus percept. This work has a multifold focus of: i) developing and modeling the function of a miniature magnetic coil that can be used for TMS in rodents, ii) establishing a reliable mouse model of tinnitus that can be used for assessing

APA, Harvard, Vancouver, ISO, and other styles

22

Suyama, John M. "Dose-Effect vs. Good Enough Level: A Comparison of Treatment Length and Maintenance of Treatment Gains at Follow-Up Using the Outcome Questionnaire-45." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3736.

Full text

Abstract:

This study examines psychotherapy response in connection to treatment duration and maintenance of treatment gains. The dose-effect perspective (Howard et al. 1986) first proposed applying medical terminology to investigate a level of exposure to a dose of psychotherapy (in number of sessions) where individuals can expect to receive sufficient benefit (i.e., 48 -- 58% of clients can be expected to sufficiently benefit from therapy by 8 sessions). The proponents of the Good Enough Level (Barkham et at. 2006) argued that mere exposure to therapy is not an effective measure for client benefit, but

APA, Harvard, Vancouver, ISO, and other styles

23

Joshi, Deepak. "Recurrent hepatitis C virus infection post liver transplantation : predictors of fibrosis and treatment response." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/recurrent-hepatitis-c-virus-infection-post-liver-transplantation(e916f7ed-9931-4f3b-8555-4833f90a3586).html.

Full text

Abstract:

Infection with chronic hepatitis C virus (HCV) is the leading indication for liver transplantation. Recurrence, however of HCV is universal after liver transplantation and subsequent fibrosis rates after transplantation are accelerated leading to significant morbidity and mortality. In addition, treatment of recurrent HCV after transplantation with pegylated-interferon (PEG) and ribavirin (RBV) are poorly tolerated and are associated with inferior treatment outcomes. The ability to therefore understand the mechanisms that relate to disease recurrence and therefore develop markers of fast fibro

APA, Harvard, Vancouver, ISO, and other styles

24

Dunn, Allison B. "Influence of perceived self-efficacy on treatment outcomes for aphasia." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000583.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Sankar, Anjali. "Neural correlates of treatment in depression and potential predictors of diagnosis and clinical response." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/neural-correlates-of-treatment-in-depression-and-potential-predictors-of-diagnosis-and-clinical-response(13ba68b2-7873-47b8-8c7b-0efa09dcefb9).html.

Full text

Abstract:

The works presented in this thesis examine the neural effects of treatment on different features of depression, such as affective biases, working memory impairments and dysfunctional thinking. The thesis opens with a review of longitudinal studies that examined the effects of antidepressants and psychological therapies on the neural correlates of affective and cognitive processing. Motivated by the paucity in the number of fMRI studies that examined psychotherapy in depression, Chapter 2 examines the effects of Cognitive Behavioural Therapy (CBT) on dysfunctional thinking in depression. In Cha

APA, Harvard, Vancouver, ISO, and other styles

26

Dann, Rebekkah S. Koch Gary G. "Methods for strengthening the design and analysis of clinical trials to show non-inferiority of a new treatment to a reference treatment for a binary response variable." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,705.

Full text

Abstract:

Thesis (DrPH)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctorate of Public Health in the School of Public Health (Biostatistics)." Discipline: Biostatistics; Department/School: Public Health.

APA, Harvard, Vancouver, ISO, and other styles

27

Swaidan, Victoria R. "Strategies to Adjust for Response Bias in Clinical Trials: A Simulation Study." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7648.

Full text

Abstract:

Background: Response bias can distort treatment effect estimates and inferences in clinical trials. Although prevention, quantification, and adjustments have been developed, current methods are not applicable when subject-level reliability is used as the measure of response bias. Thus, the objective of the current study is to develop, test, and recommend a series of bias correction strategies for use in these cases. Methods: Monte Carlo simulation and logistic regression modeling were used to develop the strategies, examining the collective impact of sample size (N), effect size (ES), reliabil

APA, Harvard, Vancouver, ISO, and other styles

28

Blake, Crystal. "Anti-Depressive and Anti-Obesity Changes Following Either Dietary Isoflavone Treatment or Injection Treatment with the Isoflavonoid Equol: Positive Response Dependent on Animal Age and Ovarian Status in Female Long Evans Rats." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/3036.

Full text

Abstract:

Two conditions associated with ovarian depletion are increased potential for depressive episodes and increased abdominal weight gain. In five different experiments we examined the effect of soy-containing diets or equol injections on depression, serotonin levels, weight gain (BW) and white adipose tissue (WAT) deposition of female Long-Evans rats in various stages of life. Rats were intact, ovariectomized or experienced natural ovarian failure (NOF). While this paper will present each experiment, only experiment 5 is outlined here due to space limitations. From conception the rats were exposed

APA, Harvard, Vancouver, ISO, and other styles

29

Marsh, Julia Anne. "Effect of black cohosh on MCF-7 human breast cancer cell growth and response to treatment with doxorubicin and paclitaxel." [New Haven, Conn. : s.n.], 2008. http://ymtdl.med.yale.edu/theses/available/etd-12092008-134138/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Botaro, Juliana Aparecida. "Otimização para a obtençao de extrato aquoso de tremoço branco (Lupinus albus L.) adicionado de suco de pitanga /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/88597.

Full text

Abstract:

Orientador: José Paschoal Batistuti<br>Banca: Rubens Monti<br>Banca: Alice Yoshiko Tanaka<br>Resumo: Recentemente, a indústria de alimentos está preocupada em desenvolver novos produtos, usando ingredientes inovadores, que promovam benefícios à saúde. O uso de proteínas de leguminosas como uma alternativa para a proteína animal tem sido estudada. O tremoço branco (Lupinus albus L.) apresenta elevada concentração de proteína e óleo, principalmente ácidos graxos insaturados e poliinsaturados, fibra alimentar, açúcares e vitaminas B1 e B2. Por outro lado, o tremoço não pode ser consumido diretame

APA, Harvard, Vancouver, ISO, and other styles

31

Salaminiou, Evangelia Eva. "Families in multiple family therapy for adolescent anorexia nervosa : response to treatment experience and family and individual change." Thesis, King's College London (University of London), 2005. https://kclpure.kcl.ac.uk/portal/en/theses/families-in-multiple-family-therapy-for-adolescent-anorexia-nervosa--response-to-treatment-experience-and-family-and-individual-change(0821fff6-e4d4-4111-b843-6a0aa6bff85c).html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Taylor, Benjamin Peter. "Quantifying functional imaging modalities and their application in the assessment of treatment response and prognosis in bone metastases." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/quantifying-functional-imaging-modalities-and-their-application-in-the-assessment-of-treatment-response-and-prognosis-in-bone-metastases(9799a78c-5b3e-4fc7-aad5-1be45f7cda37).html.

Full text

Abstract:

Bone metastases are common in malignancy and cause morbidity. However, assessing treatment response of bone metastases with morphological changes is insensitive, variable and lacks specificity. This thesis reports initial recruitment data from three prospective trials, examining the potential role of functional imaging methods as early biomarkers of response and prognosis. Breast and prostate cancer patients with bone metastases had 18F-Fluoride Positron Emission Tomography (PET) and Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) before treatment and again at 8-12 weeks following treat

APA, Harvard, Vancouver, ISO, and other styles

33

Blaker, Paul Andrew. "A search for novel biomarkers predicting toxicity and response to thiopurine treatment in patients with inflammatory bowel disease." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/a-search-for-novel-biomarkers-predicting-toxicity-and-response-to-thiopurine-treatment-in-patients-with-inflammatory-bowel-disease(7113dbba-470c-4bbd-a5d6-2cb861b3dfdf).html.

Full text

Abstract:

The thiopurines, mercaptopurine (MP) and its pro-drug azathioprine (AZA), are the first line immunomodulators used in the management of inflammatory bowel disease (IBD). Unfortunately, 30 - 40% of patients are unable to derive benefit from these medicines as a result of drug toxicity or treatment non-response. The main active metabolites of these drugs are the phosphorylated thioguanine nucleotides (TGNs) and methylated derivatives of mercaptopurine (MeMP). Recent experience suggests that measurement of these metabolites can be used to explain inter-individual variation in response to treatmen

APA, Harvard, Vancouver, ISO, and other styles

34

Hornung, Benjamin. "Anal Acoustic Reflectometry in the evaluation of the anal sphincter and the response to treatment of faecal incontinence." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/anal-acoustic-reflectometry-in-the-evaluation-of-the-anal-sphincter-and-the-response-to-treatment-of-faecal-incontinence(723292f1-672f-4672-b4ef-89865db1fd71).html.

Full text

Abstract:

Anal Acoustic Reflectometry (AAR) is a novel technique providing a dynamic physiological assessment of anal sphincter function. In AAR wide band sound waves are transmitted into a thin polyurethane bag placed within the anal canal. The reflection of these sound waves allows calculation of the cross-sectional area of the anal canal. The bag is slowly inflated and deflated, during which simultaneous cross-sectional area and pressure measurements are taken along the entire length of the anal canal. This allows Opening Pressure, Opening Elastance, Closing Pressure, Closing Elastance and Hysteresis

APA, Harvard, Vancouver, ISO, and other styles

35

Nelson, Tasha K. "A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus aureus and Other Wound Pathogens." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3911.

Full text

Abstract:

Skin related injuries are some of the most dangerous forms of wounds. In addition to treating the wound itself, health care providers must be cautious of microbial infections. In this study, we evaluate a novel all-natural antimicrobial gel compound (AMG) designed to kill planktonic bacteria, penetrate bacterial biofilms, and accelerate wound healing. In -vitro experiments demonstrate that AMG is effective in inhibiting planktonic growth and biofilm development of eight common pathogens. LIVE/DEAD staining and confocal microscopy reveal that planktonic growth and three-dimensional structure of

APA, Harvard, Vancouver, ISO, and other styles

36

Jallad, Samer. "Biomedical markers of response to intravesical BCG treatment in high-grade non-muscle invasive (PTA and PT1) transitional cell carcinoma of the bladder." Thesis, University of Brighton, 2015. https://research.brighton.ac.uk/en/studentTheses/9dab009b-4eaa-4f3a-a14c-a941f3948ccb.

Full text

Abstract:

Intravesical Bacillus Calmette–Guérin (BCG) immunotherapy is the main treatment for bladder high-grade non-muscle invasive transitional cell carcinoma (HGNMITCC) following initial resection. Unfortunately, about 30% of patients will not respond to treatment and they carry a high risk of disease progression. The alternative, radical cystectomy, has major risks with high morbidity and mortality. The ability to predict the response to BCG treatment would be a useful tool in the selection of appropriate treatment modalities. This study investigated a variety of detectable immune responses in blood

APA, Harvard, Vancouver, ISO, and other styles

37

Mohiyiddeen, Lamiya. "The role of FSH receptor gene polymorphisms in the prediction of ovarian response in patients undergoing in-vitro fertilization (IVF) treatment." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-fsh-receptor-gene-polymorphisms-in-the-prediction-of-ovarian-response-in-patients-undergoing-invitro-fertilization-ivf-treatment(7e2e1b13-a352-4ba4-9463-40dc299cedd2).html.

Full text

Abstract:

Background: The ovarian response to follicle stimulating hormone (FSH) stimulation in assisted conception cycles is variable. Although it would be beneficial to predict accurately the response of patients to FSH, to date no robust predictors of ovarian performance have been identified. Recently, there have been a number of studies on the effect of single nucleotide polymorphisms (SNP) in the FSH receptor gene and its predictive value in the patients undergoing ovarian stimulation. Several reports have shown that two common SNPs at positions 307 and 680 in exon 10 of the FSH receptor gene are a

APA, Harvard, Vancouver, ISO, and other styles

38

O'Keeffe, Breda Victoria. "The Effects of Fluency Training on Implementation Fidelity of a Reading Intervention Conducted by Paraprofessionals." DigitalCommons@USU, 2009. https://digitalcommons.usu.edu/etd/452.

Full text

Abstract:

Improving educational outcomes involves many variables, including identifying effective interventions and ensuring that they are effectively implemented in schools. Within a "response to intervention" model, treatment integrity of academic interventions has become increasingly important. However, recent research has suggested that ensuring treatment integrity by instructional staff may require intensive coaching, including daily or weekly performance feedback. This system may be unsustainable in typical schools because of limited resources for supervision. Some studies have found that treatmen

APA, Harvard, Vancouver, ISO, and other styles

39

Pathak, Ryan. "Investigating methods to improve sensitivity of the Apparent Diffusion Coefficient, a potential imaging biomarker of treatment response, for patients with colorectal liver metastasis." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/investigating-methods-to-improve-sensitivity-of-the-apparent-diffusion-coefficient-a-potential-imaging-biomarker-of-treatment-response-for-patients-with-colorectal-liver-metastasis(cf5b0308-7959-40ea-832e-862b7b816e26).html.

Full text

Abstract:

Radiological imaging already has a key role in the detection and management of patients with metastatic colorectal cancer (mCRC). With the evolution of personalised medicine there is a need for non-invasive imaging biomarkers that can detect early tumour response to targeted therapies. Translation from bench to bedside requires a multicentre approach that follows an agreed development roadmap to ensure that the proposed biomarker is precise (reproducible/ repeatable) and accurate in its characterisation of a meaningful physiological, pathological or post treatment response. The following thesi

APA, Harvard, Vancouver, ISO, and other styles

40

Park, Jennifer M. "Does D-Cycloserine Augmentation of CBT Improve Therapeutic Homework Compliance for Pediatric Obsessive Compulsive Disorder?" Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3282.

Full text

Abstract:

D-cycloserine (DCS), a partial agonist that acts on the N-methyl-D-aspartate (NMDA) receptor of the glutamatergic receptor complex, may enhance fear extinction learning during exposure-based therapy. Clinical studies in adults with obsessive-compulsive disorder (OCD) and non-OCD anxiety disorders - and a recent trial in pediatric OCD - have shown that DCS can improve treatment response to exposure therapy relative to placebo and exposure therapy. Some have hypothesized that improved treatment response is a function of increased compliance and engagement in therapeutic homework tasks, a core

APA, Harvard, Vancouver, ISO, and other styles

41

Mickelson, Bryan K. "Client Change in Multi-Model Treatment: A Comparison of Change Trajectories in Group, Individual, and Conjoint Formats in a Counseling Center." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2758.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Boussaha, Basma El Amel. "Response selection for end-to-end retrieval-based dialogue systems." Thesis, Nantes, 2019. http://www.theses.fr/2019NANT4080.

Full text

Abstract:

Le besoin croissant en assistance humaine a poussé les chercheurs à développer des systèmes de dialogue automatiques, intelligents et infatigables qui conversent avec les humains dans un langage naturel pour devenir soit leurs assistants virtuels ou leurs compagnons. L’industrie des systèmes de dialogue est devenue populaire cette dernière décennie, ainsi, plusieurs systèmes ont été développés par des industriels comme des académiques. Dans le cadre de cette thèse, nous étudions les systèmes de dialogue basés sur la recherche de réponse qui cherchant la réponse la plus appropriée à la conversa

APA, Harvard, Vancouver, ISO, and other styles

43

Knopp, Jasmin. "Individual differences in response to brief psychological interventions : using a mixed methods design to identify the role of user characteristics in the treatment of Obsessive-Compulsive Disorder (OCD)." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/individual-differences-in-response-to-brief-psychological-interventions-using-a-mixed-methods-design-to-identify-the-role-of-user-characteristics-in-the-treatment-of-obsessivecompulsive-disorder-ocd(8e5409f1-0c2f-434e-9ba6-a0c402afbc7d).html.

Full text

Abstract:

Background: OCD is a debilitating mental health condition. Poor access to evidence-based psychological treatment has motivated the implementation of low intensity interventions in UK mental health services for OCD. Around one half of those accessing care remain clinically unwell. Service users, providers, and treatment decision-makers could benefit from understanding users' views of low intensity interventions and knowing which users are more likely to benefit from diverse low intensity approaches in order to match individuals with treatments of known efficacy. Aim and objectives: The primary

APA, Harvard, Vancouver, ISO, and other styles

44

McNamara, Kiersty. "Further Evaluation of Treatments for Vocal Stereotypy: Response Interruption Redirection and Response Cost." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/7061.

Full text

Abstract:

The purpose of this study was to expand on research by evaluating the effects of response interruption redirection and response cost alone to reduce vocal stereotypy and to evaluate whether response cost increases the effectiveness of response interruption redirection. Treatment phases included response interruption redirection, response cost, and response interruption redirection plus response cost. We saw high rates of vocal stereotypy during baseline, toy baseline, and pre-intervention phases. During all treatment phases, we saw substantial decreases in stereotypy. For t

APA, Harvard, Vancouver, ISO, and other styles

45

Byström, Per. "Colorectal cancer treatment and early response evaluation how do we best evaluate treatment response? /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-766-5/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Peng, Ting. "Influence of detailing on response of dapped end beams." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40838.

Full text

Abstract:

Influence of Detailing on Response of Dapped End Beams Abstract This research investigated the behaviour of disturbed regions in dapped end beams. In this experimental research programme, two dapped end beams with similar geometry were designed and tested. Each had a span of 3 m, but each of the four different dapped ends utilized a different reinforcing detail. The main parameters studied in this research were the anchorage of the hanger reinforcement and the flexural reinforcement. The dapped ends were detailed in accordance with the provisions of the 2004 CSA Standard A23.3, as well as the

APA, Harvard, Vancouver, ISO, and other styles

47

Mancini, Valerio. "Response of Flush End-Plate Joints under Combined Actions." Doctoral thesis, Università degli studi di Trento, 2012. https://hdl.handle.net/11572/368703.

Full text

Abstract:

In this work, aspects concerning the behaviour of steel joints under combined actions are investigated. Adopting the philosophy of the component method the attention focused on the analysis of a basic component of the connection: the T-stub. Research works carried out in the recent past extensively investigated the T-stub response under tension, while no data are available for the T-stub's response under combined tension (N) and shear force (V). In the thesis experimental, numerical and theoretical studies on this topic are presented. The starting point is the experimental activity carried out

APA, Harvard, Vancouver, ISO, and other styles

48

Mancini, Valerio. "Response of Flush End-Plate Joints under Combined Actions." Doctoral thesis, University of Trento, 2012. http://eprints-phd.biblio.unitn.it/709/1/PhD_Thesis_Valerio_Mancini.pdf.

Full text

Abstract:

In this work, aspects concerning the behaviour of steel joints under combined actions are investigated. Adopting the philosophy of the component method the attention focused on the analysis of a basic component of the connection: the T-stub. Research works carried out in the recent past extensively investigated the T-stub response under tension, while no data are available for the T-stub's response under combined tension (N) and shear force (V). In the thesis experimental, numerical and theoretical studies on this topic are presented. The starting point is the experimental activity carried ou

APA, Harvard, Vancouver, ISO, and other styles

49

Eslinger, Jessica G. "Factors Affecting End of Treatment Symptom Severity for Children Receiving Trauma-Informed Evidence-Based Treatment." UKnowledge, 2013. http://uknowledge.uky.edu/csw_etds/6.

Full text

Abstract:

The purpose of this project is to examine how the factors of gender, placement status, type of treatment, the number of different types of trauma experienced, and a child’s age at the start of treatment may influence end of treatment symptom severity scores for children ages 2-12 years who received trauma-informed evidence-based treatment for trauma. Method: Caregivers and children receiving outpatient services (N=134) completed the Child Behavioral Checklist, Trauma Symptom Checklist for Young Children, and the Trauma Symptom Checklist for Children-Alternate Version at baseline and end of tre

APA, Harvard, Vancouver, ISO, and other styles

50

Hedlund-Åström, Anna. "Model for End of Life Treatment of Polymer Composite Materials." Doctoral thesis, KTH, Machine Design (Div.), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-451.

Full text

Abstract:

<p>Because of increasing environmental demands, especially on dealing with products end of life phase, product manufacturers and designers must consider the future disposal of their products. For conventional materials like steel and aluminium well-functioning recycling methods exists. This is not the case for structures of polymer composites, which are used more extensively, especially for structures like vehicles and vessels. Several techniques do exist but they are not yet commercially available. The current disposal methods of polymer composites are landfill and incineration.</p><p>Polymer

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!