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1

Vadzyuk, S. N., and P. S. Tabas. "ENDOCRINE FUNCTION OF SKELETAL MUSCLES." Fiziolohichnyĭ zhurnal 71, no. 3 (2025): 120–32. https://doi.org/10.15407/fz71.03.120.

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Myokines are signaling molecules produced by skeletal muscle in response to exercise and exert a wide range of physiological effects in various organs and tissues. They play a key role in regulating metabolic processes, modulating the immune response, and maintaining homeostasis of the body. The relationship between the level of physical activity and the production of myokines determines their therapeutic potential in maintaining cardiovascular and nervous system health. Studies also show that certain types of physical activity can activate different myokines, which allows for targeted effects
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2

Adorni, Maria Pia, Nicoletta Ronda, Franco Bernini, and Francesca Zimetti. "High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives." Cells 10, no. 3 (2021): 574. http://dx.doi.org/10.3390/cells10030574.

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Over the years, the relationship between high-density lipoprotein (HDL) and atherosclerosis, initially highlighted by the Framingham study, has been revealed to be extremely complex, due to the multiple HDL functions involved in atheroprotection. Among them, HDL cholesterol efflux capacity (CEC), the ability of HDL to promote cell cholesterol efflux from cells, has emerged as a better predictor of cardiovascular (CV) risk compared to merely plasma HDL-cholesterol (HDL-C) levels. HDL CEC is impaired in many genetic and pathological conditions associated to high CV risk such as dyslipidemia, chr
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Avecilla, Vincent, Mayur Doke, and Quentin Felty. "Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease." BioMed Research International 2017 (2017): 1–22. http://dx.doi.org/10.1155/2017/6307109.

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The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance, atherosclerosis, pulmonary disease, and degenerative disorders including dementia constitutes a serious public health problem. The Inhibitor of DNA Binding/Differentiation-3 (ID3), a member of the ID family of transcriptional regulators, has been shown to play a role in adipogenesis and therefore ID3 may influence obesity and metabolic health in response to environmental factors. This review will highlight the current understanding of how ID3 may contribute to complex chron
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4

Sidelkovskiy, A., and O. Gasiyk. "Gerontological aspects of healthy nutrition." INTERNATIONAL NEUROLOGICAL JOURNAL 19, no. 3 (2023): 80–82. http://dx.doi.org/10.22141/2224-0713.19.3.2023.1002.

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Balanced and rational nutrition is an integral part of the multifaceted concept of health and longevity. In the first half of life, the impact of irrational nutrition is usually compensated by the functional activity of all organs and systems that support the effective activity of the body, but over the years, and especially in people of the older age group, the reserve capacity of the gastrointestinal tract, endocrine, cardiovascular and metabolic systems have limited ability to provide the necessary balance of homeostasis. A lot of attention has always been paid to the issues of healthy nutr
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5

Meier, Ursula, and Axel M. Gressner. "Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin." Clinical Chemistry 50, no. 9 (2004): 1511–25. http://dx.doi.org/10.1373/clinchem.2004.032482.

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Abstract Background: Recent studies point to the adipose tissue as a highly active endocrine organ secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to take part in the regulation of energy metabolism. Approach: This review summarizes recent knowledge on leptin and its receptor and on ghrelin, adiponectin, and resistin, and emphasizes their roles in pathobiochemistry and clinical chemistry. Content: Leptin, adiponectin, and resistin are produced by the adipose tissue. The protein leptin, a satiety hormone, regulates appetite and energy balance of the body
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Lysenko, R. B., R. M. Riabushko, H. A. Oksak, D. A. Shcherban, H. Yu Skrypnyk, and A. P. Stepanchuk. "DIAGNOSIS AND TREATMENT OF PERIPHERAL ARTERIAL DISEASE IN PATIENTS WITH DIABETES MELLITUS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 23, no. 3 (2023): 198–202. http://dx.doi.org/10.31718/2077-1096.23.3.198.

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Patients with endocrine disorders often present with concomitant cardiovascular diseases. Peripheral arterial disease (PAD) in individuals with type 2 diabetes exhibits various clinical characteristics and diverse consequences. One of its primary manifestations is macrovascular complications. Although atherosclerosis is the primary cause, other contributory factors come into play. Notably, individuals with diabetes experience a more severe clinical course, marked by higher amputation rates and significant differences in mortality. The ankle-brachial index (ABI) is the standard diagnostic tool
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7

Rigalli, Juan Pablo, Guillermo Nicolás Tocchetti, and Johanna Weiss. "Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects." Current Medicinal Chemistry 26, no. 7 (2019): 1079–112. http://dx.doi.org/10.2174/0929867324666170920141707.

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ABC transporters are membrane proteins mediating the efflux of endo- and xenobiotics. Transporter expression is not static but instead is subject to a dynamic modulation aiming at responding to changes in the internal environment and thus at maintaining homeostatic conditions. Nuclear receptors are ligand modulated transcription factors that get activated upon changes in the intracellular concentrations of the respective agonists and bind to response elements within the promoter of ABC transporters, thus modulating their expression and, consequently, their activity. This review compiles inform
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8

Ryabova, E. A., and I. Y. Ragino. "Proinflammatory adipokines and cytokines in abdominal obesity as a factor in the development of atherosclerosis and renal pathology." Ateroscleroz 17, no. 4 (2022): 101–10. http://dx.doi.org/10.52727/2078-256x-2021-17-4-101-110.

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In recent decades, there has been an increase in the prevalence of overweight and obesity. Obesity has become an underestimated pandemic and a public health threat around the world. Adipose tissue is positioned as an endocrine organ that secretes a wide range of pro-inflammatory cytokines and adipokines, inducing a state of chronic subinflammation. The results of epidemiological studies over the past 30 years have also shown that visceral adipose tissue is an independent risk factor for the development of atherosclerosis, cardiometabolic diseases and chronic kidney disease. We performed a syst
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9

Dourado, Marclébio, Frederico Cavalcanti, Lucio Vilar, and Amaury Cantilino. "Relationship between Prolactin, Chronic Kidney Disease, and Cardiovascular Risk." International Journal of Endocrinology 2020 (June 22, 2020): 1–6. http://dx.doi.org/10.1155/2020/9524839.

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CKD has a high prevalence worldwide, mainly due to its main etiologies—diabetes and hypertension. It has high cardiovascular morbidity and mortality, with traditional risk factors such as atherosclerosis, hypertension, diabetes, smoking, and left ventricular hypertrophy being common. Nontraditional cardiovascular risk factors, such as anemia, hyperparathyroidism, chronic inflammation, and microalbuminuria, are also well studied. Prolactin is a hormone not only related to lactation but also being considered a uremic toxin by some authors. It accumulates with loss of renal function, and it is as
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10

Ali, Aus Tariq, Faisal Al-Ani, and Osamah Al-Ani. "Childhood obesity: causes, consequences, and prevention." Česká a slovenská farmacie 71, no. 5 (2022): 21–36. http://dx.doi.org/10.5817/csf2023-1-21.

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As a result of the dramatic increase in the prevalence of overweight and obesity among children, childhood obesity is one of the most critical global public health challenges of the 21st century. Weight gain occurs when energy intake exceeds energy expenditure. Both genetic and environmental factors (such as a sedentary lifestyle) are implicated in its pathogenesis. Childhood obesity is associated with physical, psychological, and social consequences. Obese children are at higher risk of elevated fasting blood glucose, insulin resistance, impaired glucose tolerance, type 2 diabetes, hypertensi
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11

Meiliana, Anna, and Andi Wijaya. "Peroxisome Proliferator–Activated Receptors and The Metabolic Syndrome." Indonesian Biomedical Journal 1, no. 1 (2009): 4. http://dx.doi.org/10.18585/inabj.v1i1.79.

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BACKGROUND: Obesity is a growing threat to global health by virtue of its association with insulin resistance, inflammation, hypertension, and dyslipidemia, collectively known as the metabolic syndrome (MetS). The nuclear receptors PPARα and PPARγ are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively, and drugs that modulate these receptors are currently in clinical use. More recent work on the PPARδ has uncovered a dual benefit for both hypertriglyceridemia and insulin resistance, highlighting the broad potential of PPARs in the treatment of metabolic disease.C
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12

Siusiuka, V. G., M. Y. Sergienko, O. I. Мakarchuk, A. О. Shevchenko, and O. V. Deinichenko. "Gynecological and dermatological aspects of diagnostics of polycystic ovary syndrome from puberty to menopause." Reproductive health of woman, no. 6 (September 29, 2023): 7–14. http://dx.doi.org/10.30841/2708-8731.6.2023.289991.

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The article is devoted to the review of scientific publications on gynecological and dermatological aspects of polycystic ovary syndrome (PCOS) in different age periods of women’s life. Analysis of domestic and foreign publications presents that the prevalence of PCOS depends on the age of women and the state of their reproductive function, and is accounted 17% in women 21 to 30 years old and significantly decreased with age. More than half of all cases of endocrine infertility (50-75%) and about 20-22% of the causes of infertile marriage in general are associated with PCOS. The phenotypic het
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13

Dimopoulos, Konstantinos, Andrew Constantine, Paul Clift, et al. "Cardiovascular Complications of Down Syndrome: Scoping Review and Expert Consensus." Circulation 147, no. 5 (2023): 425–41. http://dx.doi.org/10.1161/circulationaha.122.059706.

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Cardiovascular disease is a leading cause of morbidity and mortality in individuals with Down syndrome. Congenital heart disease is the most common cardiovascular condition in this group, present in up to 50% of people with Down syndrome and contributing to poor outcomes. Additional factors contributing to cardiovascular outcomes include pulmonary hypertension; coexistent pulmonary, endocrine, and metabolic diseases; and risk factors for atherosclerotic disease. Moreover, disparities in the cardiovascular care of people with Down syndrome compared with the general population, which vary across
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14

Dobrescu, Mariana, Diana Păun, Daniel Grigorie, and Cătălina Poiană. "Hormonal Mechanisms in Atherosclerosis." Internal Medicine 17, no. 3 (2020): 19–35. http://dx.doi.org/10.2478/inmed-2020-0114.

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AbstractCardiovascular disease is a complex process that includes genetic, inflammatory and endocrine components. During the last decades, much emphasis has been given to cholesterol and lipids as the primary determinants in cardiovascular disease. However, many endocrine and biochemical factors are involved in the atherosclerosis process as well, both systemically and vascular. Multiple obvious data suggest that hormones are responsible for subtle cardiovascular changes long before the development of overt atherosclerotic. Much research remains to be done regarding the interaction between end
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15

KALTENBACH, JANE C. "Endocrine Aspects of Homeostasis." American Zoologist 28, no. 2 (1988): 761–73. http://dx.doi.org/10.1093/icb/28.2.761.

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16

Shalet, SM. "Endocrine aspects of cancer." British Journal of Cancer 70, no. 3 (1994): 569. http://dx.doi.org/10.1038/bjc.1994.347.

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17

Glass, Allan R. "Endocrine Aspects of Obesity." Medical Clinics of North America 73, no. 1 (1989): 139–60. http://dx.doi.org/10.1016/s0025-7125(16)30696-4.

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18

Proietto, Joseph. "Endocrine aspects of obesity." Molecular and Cellular Endocrinology 316, no. 2 (2010): 103. http://dx.doi.org/10.1016/j.mce.2009.12.004.

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19

Sica, G. "Pathophysiologic and Endocrine Aspects." Journal of International Medical Research 18, no. 1_suppl (1990): 8–10. http://dx.doi.org/10.1177/03000605900180s103.

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20

Drent, M. "Endocrine aspects of obesity." Netherlands Journal of Medicine 47, no. 3 (1995): 127–36. http://dx.doi.org/10.1016/0300-2977(95)00008-b.

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21

Vagenakis, A. G. "Endocrine aspects of menopause." Clinical Rheumatology 8, S2 (1989): 48–51. http://dx.doi.org/10.1007/bf02207233.

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22

Rapaport, Robert. "Endocrine Aspects of Aging." Endocrinology and Metabolism Clinics of North America 52, no. 2 (2023): xiii. http://dx.doi.org/10.1016/j.ecl.2023.02.007.

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23

Murialdo, G., and G. Tamagno. "Endocrine aspects of neurosarcoidosis." Journal of Endocrinological Investigation 25, no. 7 (2002): 650–62. http://dx.doi.org/10.1007/bf03345093.

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24

Aboimova, E. V., and G. A. Azamatova. "Endocrine ophthalmopathy: historical aspects." Modern technologies in ophtalmology, no. 5 (October 6, 2023): 7–10. http://dx.doi.org/10.25276/2312-4911-2023-5-7-10.

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The article presents the history of the development of the treatment of endocrine ophthalmopathy from the first mention of disparate symptoms of the disease in 110 ad to the principles of therapy accepted today. Caleb parry was the first to describe 8 such patients, but his work did not attract the attention of the medical community. In 1835, the Englishman robert graves, in his «clinical lectures», described 3 patients with a disease that was later named after him. a little later, the clinical cases of 4 patients were presented by Karl Basedow, who also suggested that the body was «poisoned»
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25

Woollard, Kevin J. "Immunological aspects of atherosclerosis." Clinical Science 125, no. 5 (2013): 221–35. http://dx.doi.org/10.1042/cs20120576.

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Cardiovascular disease is the leading cause of death in several countries. The underlying process is atherosclerosis, a slowly progressing chronic disorder that can lead to intravascular thrombosis. There is overwhelming evidence for the underlying importance of our immune system in atherosclerosis. Monocytes, which comprise part of the innate immune system, can be recruited to inflamed endothelium and this recruitment has been shown to be proportional to the extent of atherosclerotic disease. Monocytes undergo migration into the vasculature, they differentiate into macrophage phenotypes, whic
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26

Garrido-Urbani, S., M. Meguenani, F. Montecucco, and B. A. Imhof. "Immunological aspects of atherosclerosis." Seminars in Immunopathology 36, no. 1 (2013): 73–91. http://dx.doi.org/10.1007/s00281-013-0402-8.

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27

Kipshidze, N., and N. Shavgulidse. "Genetic aspects of atherosclerosis." Atherosclerosis 115 (June 1995): S84. http://dx.doi.org/10.1016/0021-9150(95)96572-a.

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28

Pylov, Daniel, and Larysa Zhuravlyova. "EXOCRINE AND ENDOCRINE PANCREATIC INSUFFICIENCY IN DEVELOPMENT OF ATHEROSCLEROSIS." Inter Collegas 7, no. 4 (2020): 159–63. http://dx.doi.org/10.35339/ic.7.4.159-163.

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Objective: To evaluate the effect of chronic pancreatitis (CP) and exocrine insufficiency of the pancreas on the carotid intima media thickness (cIMT) in patients with type 2 diabetes mellitus (DM-2). Materials and methods: 91 patients were examined, they were divided into groups: 1st group-patients with DM-2 (n = 31) group 2nd – DM-2 combined with CP (n = 60). Fasting plasma glucose (FPG), HbA1c, immunoreactive insulin (IRI), HOMA-IR index, C-reactive protein (CRP), serum α-amylase and fecal-1 elastase (FE-1) were assessed. In order to assess the thickness of the cIMT, ultrasound of the commo
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29

Sonino, N., J. Guidi, and GA Fava. "Psychological aspects of endocrine disease." Journal of the Royal College of Physicians of Edinburgh 45, no. 1 (2015): 55–59. http://dx.doi.org/10.4997/jrcpe.2015.113.

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30

Ilić, Saša, Draško Gostiljac, Vesna Dimitrijević-Srećković, and Srđan Popović. "Endocrine aspects of Crohn's disease." Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma 24, no. 74 (2019): 7–18. http://dx.doi.org/10.5937/medgla1973007i.

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31

Sahin, Ozlem G., Elçin Kartal, and Nusret Taheri. "Meibomian Gland Dysfunction: Endocrine Aspects." ISRN Ophthalmology 2011 (October 20, 2011): 1–6. http://dx.doi.org/10.5402/2011/465198.

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Purpose. To compare the hormone levels of patients with seborrheic meibomian gland dysfunction with controls. Procedures. This is a retrospective case-control study involving 50 patients and 50 controls. Blood workup for hormones was studied in both groups by using macroELISA (enzyme-linked immunosorbent assay). Statistical evaluation was done by using SPSS 15.0 independent samples -test. Results. There were statistically significant differences of serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls (P = 0.000). Female gender showed statistically signifi
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32

Yoo, Hyung Joon. "Antiaging Efforts in Endocrine Aspects." Journal of the Korean Medical Association 50, no. 3 (2007): 234. http://dx.doi.org/10.5124/jkma.2007.50.3.234.

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33

Wu, F. C. W. "Endocrine aspects of anabolic steroids." Clinical Chemistry 43, no. 7 (1997): 1289–92. http://dx.doi.org/10.1093/clinchem/43.7.1289.

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Abstract Understanding of the mechanism of androgen action has been enhanced by advances in knowledge on the molecular basis of activation of the androgen receptor and the importance of tissue conversion of circulating testosterone to dihydrotestosterone and estradiol. New evidence supports the view that supraphysiological doses of anabolic steroids do have a definite, positive effect on muscle size and muscle strength. However, the nature of the anabolic action of androgens on muscle is currently unclear and may involve mechanisms independent of the androgen receptor. The dose–response relati
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34

Lizarazo, Adriana Herrera, Michelle McLoughlin, and Maria G. Vogiatzi. "Endocrine aspects of Klinefelter syndrome." Current Opinion in Endocrinology & Diabetes and Obesity 26, no. 1 (2019): 60–65. http://dx.doi.org/10.1097/med.0000000000000454.

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35

Higgins, NiallO'. "ENDOCRINE ASPECTS OF BREAST CANCER." ANZ Journal of Surgery 57, no. 10 (1987): 697–701. http://dx.doi.org/10.1111/j.1445-2197.1987.tb01246.x.

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36

Akopova, R. A., and T. V. Kokoreva. "ENDOCRINE ASPECTS OF MALE INFERTILITY." Bulletin "Biomedicine and sociology" 3, no. 4 (2018): 17–19. http://dx.doi.org/10.26787/nydha-2618-8783-2018-3-4-17-19.

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37

Franks, Stephen. "Endocrine Aspects of Menstrual Disorders." Medicine 29, no. 11 (2001): 34–37. http://dx.doi.org/10.1383/medc.29.11.34.28432.

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38

Currie, Gemma, David M. Carty, John M. Connell, and Marie Freel. "Endocrine aspects of pre-eclampsia." Cardiovascular Endocrinology 4, no. 1 (2015): 1–10. http://dx.doi.org/10.1097/xce.0000000000000039.

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39

Sonino, Nicoletta, and Giovanni A. Fava. "Psychological aspects of endocrine disease." Clinical Endocrinology 49, no. 1 (1998): 1–7. http://dx.doi.org/10.1046/j.1365-2265.1998.00528.x.

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40

Pantelakis, Chairmen: S., and CR Rodda. "Endocrine aspects of thalassaemia major." Acta Paediatrica 83, s406 (1994): 105–6. http://dx.doi.org/10.1111/j.1651-2227.1994.tb13435.x.

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41

Bravo, Emmanuel L. "Clinical Aspects of Endocrine Hypertension." Medical Clinics of North America 71, no. 5 (1987): 907–20. http://dx.doi.org/10.1016/s0025-7125(16)30816-1.

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42

Hofbauer, Lorenz C., Tilman D. Rachner, Robert E. Coleman, and Franz Jakob. "Endocrine aspects of bone metastases." Lancet Diabetes & Endocrinology 2, no. 6 (2014): 500–512. http://dx.doi.org/10.1016/s2213-8587(13)70203-1.

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43

Müller, B. "Endocrine aspects of critical illness." Annales d'Endocrinologie 68, no. 4 (2007): 290–98. http://dx.doi.org/10.1016/j.ando.2007.06.006.

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44

Shalet, S. M. "Endocrine Aspects of Acute Illness." Postgraduate Medical Journal 61, no. 722 (1985): 1099. http://dx.doi.org/10.1136/pgmj.61.722.1099.

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Harrison, Timothy S. "Endocrine aspects of acute illness." American Journal of Surgery 151, no. 5 (1986): 639. http://dx.doi.org/10.1016/0002-9610(86)90578-7.

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46

Pervanidou, Panagiota, Evangelia Charmandari, and George P. Chrousos. "Endocrine Aspects of Childhood Obesity." Current Pediatrics Reports 1, no. 2 (2013): 109–17. http://dx.doi.org/10.1007/s40124-013-0011-y.

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47

Boehm, B. O., and N. R. Farid. "Molecular aspects of endocrine autoimmunity." Clinical Investigator 71, no. 1 (1993): 79–81. http://dx.doi.org/10.1007/bf00210975.

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48

Beall, G. N. "Immunologic aspects of endocrine diseases." JAMA: The Journal of the American Medical Association 258, no. 20 (1987): 2952–56. http://dx.doi.org/10.1001/jama.258.20.2952.

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49

Baker, James R. "Immunologic Aspects of Endocrine Diseases." JAMA: The Journal of the American Medical Association 268, no. 20 (1992): 2899. http://dx.doi.org/10.1001/jama.1992.03490200151017.

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LIECHTY, R. DALE. "Endocrine Aspects of Acute Illness." Archives of Surgery 120, no. 11 (1985): 1327. http://dx.doi.org/10.1001/archsurg.1985.01390350103032.

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