Academic literature on the topic 'Endocrine disruptor compounds (EDCs)'
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Journal articles on the topic "Endocrine disruptor compounds (EDCs)"
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Combarnous, Yves, and Thi Mong Diep Nguyen. "Comparative Overview of the Mechanisms of Action of Hormones and Endocrine Disruptor Compounds." Toxics 7, no. 1 (2019): 5. http://dx.doi.org/10.3390/toxics7010005.
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Endocrine Disruptor Compounds (EDCs) are synthetic or natural molecules in the environment that promote adverse modifications of endogenous hormone regulation in humans and/or in wildlife animals. In the present paper, we review the potential mechanisms of EDCs and point out the similarities and differences between EDCs and hormones. There was only one mechanism, out of nine identified, in which EDCs acted like hormones (i.e. binding and stimulated hormone receptor activity). In the other eight identified mechanisms of action, EDCs exerted their effects either by affecting endogenous hormone concentration, or its availability, or by modifying hormone receptor turn over. This overview is intended to classify the various EDC mechanisms of action in order to better appreciate when in vitro tests would be valid to assess their risks towards humans and wildlife.
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Bhattacharjee, Nandini, Susmita Sarkar, and Biplab Giri. "Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note." Journal of Drug Delivery and Therapeutics 12, no. 5 (2022): 3–7. http://dx.doi.org/10.22270/jddt.v12i5.5582.
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Endocrine Disrupting Chemicals (EDCs) or Endocrine Disruptors are unique assemblage or cluster of emerging pollutants as they affect the synthesis, release and transport of hormones. EDCs have been associated with a diverse array of health issues and diseases. EDCs can alter the endocrine system and are involved in carcinogenesis and inducing poly-cystic ovary syndrome (PCOS). The objective of this article is to furnish an outline of research on environmental aspects of EDCs and their effects on human health specially on cancer and PCOS based on evidence from animal and human studies. EDCs include natural compounds such as phytoestrogens and various synthetic chemicals which are utilized by the chemical, agriculture, cosmetic and food industries. Several EDCs may work as carcinogens and causes initiation and advancement of cancer. Uterine and ovarian cancers of female have been associated with exposure to EDC. Bisphenol-A (BPA), an EDC which is found in plastic bottles, household materials, canned food, waste water, beverage containers and thermal paper, can increase risk of breast cancer. Even low levels of BPA exposure may poses threat of prostate cancer in men. Testicular cancer and thyroid cancer could be influenced by EDCs. Comprehensive studies have been conducted by many researchers in the light of toxicity pattern of EDC that render interpretation of impact of EDCs on development of cancer and PCOS inducing capacity in female reproductive system.
 Keywords: Endocrine disrupting chemicals; EDC; Cancer; Endocrine Disruptor, Poly-Cystic Ovary Syndrome; PCOS
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Combarnous, Yves. "Endocrine Disruptor Compounds (EDCs) and agriculture: The case of pesticides." Comptes Rendus Biologies 340, no. 9-10 (2017): 406–9. http://dx.doi.org/10.1016/j.crvi.2017.07.009.
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Interdonato, Livia, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, and Rosanna Di Paola. "Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis." International Journal of Molecular Sciences 24, no. 6 (2023): 5682. http://dx.doi.org/10.3390/ijms24065682.
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Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a woman’s fertility, physical health, and overall quality of life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) may be etiologically involved in the development and severity of the disease. We consider the available human evidence on EDCs and endometriosis, limiting ourselves to studies that have individually assessed chemical amounts in women. Dioxins, BPA, Phthalates, and other endocrine disruptors, like DDT, are among the evidence indicating an environmental etiology for endometriosis. Collectively, this review describes how environmental toxins are linked to lower fertility in women, as well as a number of reproductive diseases, focusing on the pathology of endometriosis and its treatments. Importantly, this review can be used to investigate techniques for preventing the negative effects of EDC exposure.
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Ehsanifar, Mojtaba, Akram Gholami, and Alireza Esmaeili. "Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals." OBM Neurobiology 09, no. 02 (2025): 1–16. https://doi.org/10.21926/obm.neurobiol.2502285.
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There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which is linked to neuropsychiatric conditions. Additionally, the global incidence of MDD has risen. Various factors like gender, genetic components, age, hormonal balance, and cultural influences may explain differences in MDD prevalence. Recently, environmental pollutants such as industrial chemicals, emollients, plastics, fungicides, and pesticides have emerged as critical factors influencing this disorder. This review delves into the influence of key phthalate and bisphenol compounds on chronic inflammation and MDD.
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Combarnous, Yves. "Hormones et perturbateurs endocriniens : quelles similitudes ? Quelles différences ? / Hormones and endocrine disruptors: what similarities? What are the differences?" Notes Académiques de l'Académie d'agriculture de France / Academic Notes of the French Academy of Agriculture 7 (2019): 1–7. http://dx.doi.org/10.58630/pubac.not.a530149.
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Endocrine disruptor compounds (EDC) are synthetic or natural compounds in the environment promoting unwanted modifications of endocrine homeostasis (regulated by endogeneous hormones) in human and/or in animals. In the present note, we describe similarities and differences between hormones and EDCs’ mechanisms of action, in order to decipher more precisely the structural and biological characteristics of the latters and to better appreciate their risks, and not only their hazards.
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García, Noelia, Rosalía Rodríguez, Gemma Vicente, Juan J. Espada, and Luis Fernando Bautista. "Comprehensive Study on Endocrine Disruptor Removal from Wastewater Using Different Microalgae Species." Applied Sciences 15, no. 1 (2024): 132. https://doi.org/10.3390/app15010132.
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The concentration of endocrine disruptor compounds (EDCs) in wastewater is increasing, posing significant risks to living organisms. This study concerns the simultaneous degradation of a variety of EDCs from wastewater, including methylparaben (MeP), propylparaben (PrP), butylparaben (BuP), benzophenone (BP), bisphenol A (BPA), and estrone (E), in the presence of the microalgae Scenedesmus sp. or Chlorella vulgaris. The potential for the abiotic removal of these EDCs and their underlying degradation mechanisms were also studied. The presence of microalgae significantly enhanced the degradation of parabens, achieving complete removal within 7 days, primarily through the mechanism of biodegradation. BPA removal was also improved by microalgae, reaching 82% and 90% within 7 days with Scenedesmus sp. and C. vulgaris, respectively. BP degradation was predominantly abiotic, accomplishing 95% removal in 7 days. E degradation was mainly abiotic, achieving approximately 40% within 7 days, with a notable contribution from a biodegradation mechanism in the later stages, accounting for 27% and 40% of the final total removal in the presence of Scenedesmus sp. and C. vulgaris, respectively. This study provides insights into the mechanisms of EDC degradation by microalgae, highlighting the potential of Scenedesmus sp. and C. vulgaris to remove a mixture of EDCs from wastewater.
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Noutsopoulos, C., D. Mamais, V. Samaras, T. Bouras, M. Marneri, and K. Antoniou. "Effect of wastewater chlorination on endocrine disruptor removal." Water Science and Technology 67, no. 7 (2013): 1551–56. http://dx.doi.org/10.2166/wst.2013.025.
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Endocrine disrupting chemicals (EDCs) are compounds of mainly anthropogenic origin that interfere with the endocrine system of animals and humans thus causing a series of disorders. Wastewater treatment plants are one of the major routes for transporting such chemicals to the water courses. In the context of this study, several chlorination batch tests were performed in order to assess the effectiveness of chlorination to remove bisphenol A (BPA), triclosan (TCS), nonylphenol (NP) and its ethoxylates (NP1EO and NP2EO) from secondary effluent. According to the results, an appreciable removal of NP, BPA and TCS to the order of 60–84% was observed as an effect of moderate chlorination doses. This was not the case for NP1EO and NP2EO as even at high chlorine doses, removal efficiencies were lower (37% for NP1EO and 52% for NP2EO). Removal efficiencies of NP, BPA and TCS are practically independent of contact time, although this was not the case for NP1EO and NP2EO. Based on toxicity experiments, it is anticipated that following chlorination of the target chemicals, production of more toxic metabolites is taking place. Therefore the effectiveness of chlorination to remove EDCs is questionable and more research is needed to guarantee safe wastewater reuse.
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Sosa-Ferrera, Zoraida, Cristina Mahugo-Santana, and José Juan Santana-Rodríguez. "Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples." BioMed Research International 2013 (2013): 1–23. http://dx.doi.org/10.1155/2013/674838.
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Endocrine-disruptor compounds (EDCs) can mimic natural hormones and produce adverse effects in the endocrine functions by interacting with estrogen receptors. EDCs include both natural and synthetic chemicals, such as hormones, personal care products, surfactants, and flame retardants, among others. EDCs are characterised by their ubiquitous presence at trace-level concentrations and their wide diversity. Since the discovery of the adverse effects of these pollutants on wildlife and human health, analytical methods have been developed for their qualitative and quantitative determination. In particular, mass-based analytical methods show excellent sensitivity and precision for their quantification. This paper reviews recently published analytical methodologies for the sample preparation and for the determination of these compounds in different environmental and biological matrices by liquid chromatography coupled with mass spectrometry. The various sample preparation techniques are compared and discussed. In addition, recent developments and advances in this field are presented.
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Schneider, Melanie, Jean-Luc Pons, Gilles Labesse, and William Bourguet. "In Silico Predictions of Endocrine Disruptors Properties." Endocrinology 160, no. 11 (2019): 2709–16. http://dx.doi.org/10.1210/en.2019-00382.
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Abstract Endocrine-disrupting chemicals (EDCs) are a broad class of molecules present in our environment that are suspected to cause adverse effects in the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous ligands. The characterization of the harmful interaction between environmental compounds and their potential cellular targets and the development of robust in vivo, in vitro, and in silico screening methods are important for assessment of the toxic potential of large numbers of chemicals. In this context, computer-aided technologies that will allow for activity prediction of endocrine disruptors and environmental risk assessments are being developed. These technologies must be able to cope with diverse data and connect chemistry at the atomic level with the biological activity at the cellular, organ, and organism levels. Quantitative structure–activity relationship methods became popular for toxicity issues. They correlate the chemical structure of compounds with biological activity through a number of molecular descriptors (e.g., molecular weight and parameters to account for hydrophobicity, topology, or electronic properties). Chemical structure analysis is a first step; however, modeling intermolecular interactions and cellular behavior will also be essential. The increasing number of three-dimensional crystal structures of EDCs’ targets has provided a wealth of structural information that can be used to predict their interactions with EDCs using docking and scoring procedures. In the present review, we have described the various computer-assisted approaches that use ligands and targets properties to predict endocrine disruptor activities.
Dissertations / Theses on the topic "Endocrine disruptor compounds (EDCs)"
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SANTANGELI, STEFANIA. "Plastic and environmental safety: the effects of EDCs on metabolism, reproduction and epigenetic processes." Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245269.
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Per inquinamento causato dalle materie plastiche si intende l’accumulo in ambiente di prodotti plastici in grado di indurre problemi sia all’ambiente che alle specie selvatiche. Il Bisfenolo A (BPA) è uno dei distruttori endocrini maggiormente prodotti a livello mondiale durante la lavorazione della plastica. Numerosi studi hanno mostrato la capacità di questo inquinante di creare effetti dannosi sia sull’uomo che sulle specie selvatiche, per cui nel tempo sono stati compiuti diversi tentativi volti a trovare delle valide alternative. Tra i possibili sostituti, in questo studio di dottorato, l’attenzione è stata focalizzata sul Dhietylene dibenzoato (DGB) ed il Diisononilftalato (DiNP).
Lo scopo principale di questo progetto è stato quindi quello di studiare l’impatto di questi plastificanti, focalizzando l’attenzione sui loro effetti nella riproduzione e nel metabolismo lipidico. Gli effetti del nonilfenolo, dell’ottilfenolo (t-OP) e del BPA sul metabolismo lipidico, sono stati inoltre analizzati in giovanili di orata.
I risultati ottenuti hanno dimostrato come, sia il BPA, che il DiNP, siano in grado di interferire con il processo di oogenesi e che, sia il BPA che il DGB, sono in grado di interferire con il metabolismo lipidico nello zebrafish.
La somministrazione a giovanili di orata di mangimi contaminati con diversi inquinanti tra cui il BPA, ha mostrato la loro capacità di indurre disordini metabolici, mostrando come oltre all’esposizione ambientale, anche il consumo di cibi contaminati possa essere considerata una fonte di esposizione importante ai contaminanti.
Concludendo, il presente progetto di dottorato, mostra la capacità di alcuni distruttori endocrini, utilizzati nella lavorazione della plastica e nei detergenti, di interferire con la riproduzione ed il metabolismo lipidico nei teleostei, agendo prevalentemente in maniera dose dipendente, secondo curve non-monotoniche e, nel caso del BPA, interferendo con i meccanismi epigenetici.<br>Plastic pollution involves the accumulation of plastic products in the environment that adversely affects wildlife and wildlife habitat. Bisphenol A (BPA) is one of the highest volume endocrine disruptor produced worldwide during the manufacturing of plastic. Due to his well-documented detrimental effects, several substitute for BPA, but also for other plasticizer of common use, have been suggested, such as Diethylene glycol dibenzoate (DGB) and Diisononyl Phthalate (DiNP).
The aim of this project is therefore to investigate the impact of several plasticizers, which are supposed to act as endocrine disruptor compounds (EDCs), focusing the attention on their effects on metabolic and reproductive system. Due to the necessity of testing a different range of concentrations in various plastic pollutants, an experimental model easy to reproduce, treat and analyse was needed; thus the choice to introduce zebrafish as experimental model for these studies.
Concomitantly, the effects of nonylpnenol (NP), 4-tert-octylphenol (t-OP) and BPA on lipid metabolism were studied in sea bream juveniles.
The results we obtained, using a multidisciplinary approach ranging from molecular to spectroscopic techniques, showed the ability of BPA and DiNP to interfere with female’s reproduction in a dose dependent manner. Concerning BPA its epigenetic effects were also demonstrated and eventually both BPA and DGB were found able to interfere with lipid metabolism in a dose dependent manner.
Furthermore t-OP, NP and BPA were demonstrated to give rise to hepatic metabolic disorders in sea bream juveniles.
In conclusion, the present PhD project, demonstrates that endocrine disruptors compounds, used in the manufacturing of plastics, are able to interfere with reproductive and metabolic system of teleost fish. Furthermore, we demonstrates the capacity of BPA to affect gene expression through the deregulation of epigenetic patterns.
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Hindman, Andrea R. "The mechanisms of BPA exposure and in the developing mammary gland." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503321233777122.
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Holbrook, Richard David Jr. "Fate and Transport of Endocrine Disrupting Compounds during Wastewater Treatment: The Role of Colloidal and Particulate Material." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/28853.
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The presence of biologically-active estrogenic endocrine disrupting compounds (EDCs) in treated effluents from biological wastewater treatment facilities has prompted wide-spread interest in the behavior of these contaminants during the activated sludge process. The yeast-estrogen screen (YES) was used to quantify the estrogenic activity of samples taken from different areas of three wastewater treatment facilities. An estrogenic mass-balance around these facilities revealed that the majority of influent estrogenic activity was removed in the activated sludge process, but the main route for EDC discharge to the natural environment was via the treated effluent. The estrogenic activity in the effluent from a membrane bioreactor (MBR) was lower compared to a fully aerobic activated sludge process using secondary clarification, suggesting that enhanced removal of particulate and colloidal material may improve EDC removal efficiency.
Colloidal material was obtained from settled mixed liquor suspended solids (MLSS) collected from a pilot MBR and a full-scale activated sludge process that included anoxic and aerobic zones. The MLSS was sized fractionated by filtration, and used to quantify the sorption coefficients for pyrene, 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) by fluorescence quenching. The MLSS-derived colloidal organic carbon (COC) sorption coefficient (Kcoc) for pyrene ranged from (< 1 to 80) L/kgcoc, indicating a similar affinity for pyrene compared to natural organic matter. Kcoc coefficients for E2 ranged between (< 1 to 158) L/kgcoc for E2 and (< 1 to 228) L/kgcoc for EE2, and are the highest E2 and EE2 sorption coefficients reported in the literature to date. There was a strong correlation between the Kcoc coefficients and molar extinction coefficient at 280 nm (e280) for pyrene and E2, suggesting that the interaction of the π;-electrons is an important factor in determining overall sorption behavior. There was no such correlation for EE2. Based on the Kcoc coefficients and COC concentrations of the samples, between 1 and 50% of the aqueous E2 and EE2 concentrations were associated with colloidal material.
In a novel application of the YES bioassay, the bioavailability of colloid-associated E2 was quantified by comparing the EC50 values of the dose-response curves generated in the presence and absence of size fractionated COC. An increase in EC50 values as a function of COC concentration was attributed to a reduction in bioavailability of E2, suggesting that MLSS-derived COC can reduce, but not eliminate, the biological impact of EDCs. However, there was a high degree of variability in the EC50 values, and estimates of the colloid-associated E2 fraction based on the Kcoc-e280 correlation were unsuccessful in accurately predicting increases in EC50 values. Nevertheless, the YES bioassay may represent a powerful tool in determining the bioavailability of EDCs in complex environmental samples.
Results from this research effort suggest that the colloidal phase derived from activated sludge systems represents an important transport vehicle whereby EDCs and other trace organic compounds can enter into the natural environment. Consequently, wastewater treatment plants discharging to sensitive ecosystems or involved with direct water reuse programs should optimize the treatment process to remove colloidal material.<br>Ph. D.
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Kleiner, Eric J. "Evaluation of Enzyme-Linked Immunosorbent Assay (ELISA) Test Kits for the Quantitative Determination of Endocrine Disrupting Compounds (EDCs) in Aqueous Phase Environmental Samples." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282056078.
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Masikini, Milua. "The use of cyclodextrin template-based metal oxide nanomaterials in the development of electrochemical sensors for phenolic endocrine disruptor compounds." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2798_1307953880.
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<p>Iron oxide nanoparticles were prepared using co-precipitation method in the presence and absence of beta-cyclodextrin (&beta<br>-CD). Such materials were characterized using transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), attenuated total reflection Fourier transform infrared (ATR-FTIR), X-ray diffraction (XRD), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA). The TEM shows that the surface morphology has no difference between nanoparticles prepared in the presence and absence of beta-cyclodextrin (&beta<br>-CD), amorphous particles with high surface area and dimensions of about 100 nm by 500 nm. The amorphous states of nanoparticles are confirmed further by XRD. The ATR-FTIR analysis confirms inclusion complex between &beta<br>-CD and nanoparticles.</p>
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Fojt, Jakub. "Stanovení organických sloučenin cínu v životním prostředí." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376809.
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Organotin compounds are one of the most produced and most used organometallic compounds. Some of these substances are endocrine disruptors, persistent organic polutants and their high toxic effects are observed. That’s why their presence in the environment caused by human activity could endanger many organisms. The aim of this thesis is summarize their properties and their occurrence in the environment. Then the quick, easy and relatively cheap method for determination of trialkyltin compounds in heavily poluted aquatic sediments using capillary zone electrophoresis is developed.
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Tetteh, Emmanuel. "Adsorption of Pharmaceuticals and Endocrine Disrupting Compounds using Unmodified and Surfactant Modified Palygorskite-Montmorillonite Clay Particles in Batch and Fixed Bed Column Modes." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1543583842195458.
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Berhane, Tedros Mesfin. "KINETIC AND EQUILIBRIUM SORPTION EXPERIMENTS INVESTIGATING PALYGORSKITE-MONTMORILLONITE AS A POTENTIAL FILTER MEDIUM FOR REMOVAL OF PHARMACEUTICALS AND ENDOCRINE-DISRUPTING COMPOUNDS." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1429882830.
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Citulski, Joel. "The Fate of Net Estrogenicity and Anti-Estrogenicity During Conventional and Advanced Biosolids Treatment Processes." Thesis, 2012. http://hdl.handle.net/10214/3285.
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Biosolids are the nutrient-rich organic residual materials resulting from the treatment of domestic sewage at a wastewater treatment facility, and are increasingly land-applied for agricultural and land-reclamation purposes as part of the wastewater management process. While the presence and fate of estrogenic endocrine-disruptors (eEDCs) in wastewater has been extensively studied, much less focus has been given to examining the presence and fate of eEDCs during biosolids treatment. In particular, little work has been done to measure the net estrogenic potency of biosolids using in vitro bioassays, such as the Yeast Estrogen Screen (YES) assay. This is despite the fact that widespread land-application of biosolids provides for the direct introduction of eEDCs into terrestrial and aquatic environments. The relative scarcity of bioassay-based net estrogenicity data for sludges and biosolids is in large part due to the analytical challenges involved in working with such a complex sample matrix.
Comprehensive sampling at wastewater treatment plants in Guelph and London, ON, demonstrated that the estrogenicity of anaerobically-treated biosolids is considerably lower (12.0-19.7 ng/g estradiol-equivalents) than that reported in earlier published studies. The results of the present study were made possible due to the development of a sample preparation methodology that overcame the toxic effects that sludge and biosolid samples typically exert on yeast cells in the YES assay. An anti-estrogenicity assay was also applied for the first time to sludges/biosolids to measure the extent to which antagonistic compounds ‘block’ the response of the YES assay. The results of these tests suggest that although the net estrogenicity of anaerobically treated solids is indeed low, up to twice the amount of estrogenicity measured by the YES assay may be masked in biosolids by the presence of antagonistic compounds.
While aerobic treatment conditions reduced net estrogenicity to at-or-below detectable levels, net estrogenicity remained relatively constant throughout the unit processes of the anaerobic treatment train. Biosolid ageing during storage led to an overall decrease in net estrogenicity of both conventionally-treated “restricted use” and advanced-treated “unrestricted use” anaerobic biosolids. However, levels of net estrogenicity were observed to spike during the early stages of storage, particularly under freeze/thaw conditions.<br>Natural Science and Engineering Research Council of Canada (NSERC) PGS-D3 scholarship, Water Environment Association of Ontario, Canadian Water Network
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Borysko, Larissa. "Effects of the synthetic hormone 17 α-ethynylestradiol on the reproduction and early life histories of the estuarine gastropods Nassarius burchardi and Nassarius jonasii / Larissa Borysko". Thesis, 2008. http://handle.uws.edu.au:8081/1959.7/506632.
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Over the past ten to fifteen years there has been a growing concern that some synthetic and naturally occurring compounds may be altering the normal function of endocrine systems in humans and wildlife. These compounds, termed Endocrine Disrupting Compounds (EDCs), have been found in many aquatic environments where they come into contact with vertebrate and invertebrate organisms. To date, natural and synthetic estrogens and xeno-estrogens have received the most attention and caused the greatest concern because they mimic the vertebrate hormone estrogen. The synthetic estrogenic hormone 17α- ethynylestradiol (EE2), a component of the birth control pill and hormone replacement therapies, has received increased scrutiny because it has been detected in aquatic environments worldwide. It has been correlated with observations of reproductive dysfunction and morphological and histological abnormalities in several studies of fish, however, little is known about the effects this compound may have on invertebrates. While internationally research has slowly begun to fill gaps in our knowledge and understanding of the effects of EDCs on invertebrate organisms, studies in Australia, with its large number of endemic species remain in their infancy. There is an urgent need to develop toxicity testing with EDCs to measure the response and determine the level of impact of these compounds in aquatic habitats in Australia. Part of the reason for the paucity of studies in Australia is the lack of general ecological knowledge of many invertebrates, especially those living in estuarine areas. These organisms are potentially vulnerable because they inhabit environments that receive waters from areas upstream containing pollutants such as EDCs.
Books on the topic "Endocrine disruptor compounds (EDCs)"
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A, Snyder Shane, and AWWA Research Foundation, eds. Removal of EDCs and pharmaceuticals in drinking and reuse treatment processes. Awwa Research Foundation, 2007.
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Patisaul, Heather B., and Scott M. Belcher. Endocrine Disruptors, Brain, and Behavior. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.001.0001.
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Hormones play a foundational role in the sex-specific organization of the brain and, consequently, the complex behaviors they coordinate. Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with hormone action and thus, possibly, our neural and mental health. If and how these endocrine-disrupting compounds (EDCs) affect the development and function of the brain, and may be contributing to neural disorders that are rapidly rising in prevalence, are the central concerns of this book. This work also examines why even the concept of endocrine disruption is controversial in some circles; how differing definitions of endocrine disruption and “adverse” outcomes shape public policy; and where the current capacity to evaluate chemicals for safety in a regulatory context begins and ends. Fundamental concepts of the EDC hypothesis, including critical windows of exposure and sexually dimorphic effects, are explained. A historical perspective on how the endocrine disruption hypothesis emerged and a summary of how and to what degree prototypical EDCs affect human brain health are provided as a prelude to a critical evaluation of the evidence linking EDC exposures to human neurobehavioral disorders. The book concludes with suggestions for future research needs and a summary of emerging technology that might prove more capable of effectively evaluating existing and new chemicals for endocrine-disrupting properties. The impossibility of disentangling the “science” of EDC action on the brain and behavior from its public health policy implications and economic influence is comprehensively addressed throughout.
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Patisaul, Heather B., and Scott M. Belcher. The Neuroendocrine System and General Mechanisms of Endocrine Disruption. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.003.0004.
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The neuroendocrine system is the interface between the endocrine and nervous systems. This chapter presents an overview of the neuroendocrine system and endogenous hormones, with a primary focus on the hypothalamic-pituitary-gonadal (HPG) axis, the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-thyroid axis (HPT). The importance of impacts of exogenous compounds, both natural and man-made, on the neuroendocrine system is discussed, with a focus on endocrine-disruptive actions of plant-derived phytoestrogens and the role of the aryl hydrocarbon receptor as an environmental sensor. The impacts of EDCs on feed-forward and negative feedback regulation of neuroendocrine functions, including those mediated by estrogen, androgen, and thyroid pathways, as well as other less studied pathways of hormonal signaling that involve disruption of neurosteroids, peptide hormones, and adrenal hormone signaling are also presented.
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Patisaul, Heather B., and Scott M. Belcher. Defining Endocrine Disruption. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.003.0002.
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Chapter 2 reviews the origin of the concept of endocrine disruption and presents a comprehensive treatment of the changing and often competing definitions of endocrine disruptors. The factors influencing the different definitions, impacts of including specific terms, such as “adverse” or “harm,” in this definition, and the important influences surrounding a specific definition are examined. Building on this background, the concept and definition of “neuroendocrine disruption” as “an exogenous chemical substance or mixture that alters the structure or function(s) of the neuroendocrine system” are presented. The distinctions between neurotoxicity and neuroendocrine disruption are delineated, and sources of endocrine-disrupting compound (EDC) exposures from man-made chemicals and “natural” compounds are discussed. Key concepts related to EDC action, including critical windows of sensitivity, early life exposure and later in life disease, multigenerational effects, non-linear and non-monotonic dose responses, low-dose and sex-specific effects, along with key toxicological definitions, are presented.
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Patisaul, Heather B., and Scott M. Belcher. Landmark Endocrine-Disrupting Compounds of the Past and Present. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.003.0003.
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This chapter focuses on four of the best known and most well characterized EDCs: the polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), diethylstilbestrol (DES), and bisphenol A (BPA) as prototypical EDCs. For each compound, historical information regarding use, sources of contamination, descriptions of toxic effects, nature of endocrine disruptive mechanisms, and detailed summaries of critical research findings are highlighted. Each of these chemicals are seminal illustrative examples of EDCs that came to be recognized, defined, and considered seriously by the general public and the regulatory community. Continuing work with these well-studied chemicals continues to reveal new mechanisms of EDC action and identifying new potential health outcomes and effects, and have become important “positive control chemicals” for toxicity and chemical testing strategies and identification of emerging EDCs.
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Removal of EDCs and Pharmaceuticals in Drinking and Reuse Treatment Processes. American Water Works Association, 2007.
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Patisaul, Heather B., and Scott M. Belcher. Risk Assessment and Chemical Regulatory Policy in the United States and Abroad. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.003.0007.
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This chapter presents an overview of the risk assessment process with an in-depth description of the related terminology. Critical study features that should be included to maximize utility of data for risk assessment for any experimental study are presented as an aid for academic scientists interested in designing studies with utility in the risk assessment process. The second half of this chapter summarizes the current state of regulatory policy regarding EDCs in the United States and abroad. Topics addressed include the Toxic Substances Control Act (TSCA) and a detailed accounting of the changes enacted by the recent 2016 revisions to TSCA. These policies are compared to the Registration Evaluation Authorization and Restriction of Chemicals (REACH) laws that govern chemical safety assessment in the European Union. The Endocrine Disruptor Screening Program (EDSP) and current efforts toward developing high-throughput methods for screening chemicals for endocrine-disrupting activity are also summarized.
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Vandenberg, Laura N. Classic Toxicology vs. New Science. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190490911.003.0012.
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Endocrine-disrupting chemicals (EDCs) are compounds that interfere with hormone action. Many EDCs are agonists or antagonists of estrogen, androgen, or thyroid hormone receptors. EDCs are found in many consumer products and are detected at low doses in humans. Using traditional methods from toxicology and risk assessment, these compounds have often been considered benign based on the low exposure levels and few overt signs of toxicity. However, thousands of epidemiology studies have found associations between EDC exposures and disease outcomes, suggesting that the methods used to prioritize chemicals and identify safe levels of exposure have failed. This chapter discusses the unique properties of EDCs that defy traditional chemical safety expectations. The presumption that chemicals are safe until proved harmful has allowed humans to be exposed to hundreds of chemicals that may be unsafe, at least during sensitive periods of development. Recommendations are offered for revising toxicologic evaluations to protect public health.
Book chapters on the topic "Endocrine disruptor compounds (EDCs)"
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Rizzo, Roberta, Daria Bortolotti, Sabrina Rizzo, and Giovanna Schiuma. "Cellular Mechanisms of Endocrine Disruption." In Environment Impact on Reproductive Health. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-36494-5_2.
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AbstractWith industrialization, the production of chemicals and their introduction into the environment have increased massively. These new agents included many chemical classes and comprise an integral part of the world economy and commerce [1]. Nevertheless, several of the chemicals used today are called endocrine-disrupting compounds (EDCs).
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Kurjogi, Mahantesh M., Gulamnabi L. Vanti, and Ram S. Kaulgud. "Endocrine Disruptor Compounds: Human Health and Diseases." In Biotechnological Innovations for Environmental Bioremediation. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-9001-3_25.
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Rathipriya, A., Deepak Agarwal, E. Suresh, and Mohd Ashraf Rather. "Endocrine-Disrupting Compounds (EDCs) as Emerging Aquatic Contaminants: Emphasis on Reproduction and Development." In Xenobiotics in Aquatic Animals. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-1214-8_21.
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Boti, Vasiliki, Vasilios Sakkas, and Triantafyllos Albanis. "Assessment of the Occurrence and Fate of Transformation Products of Endocrine Disrupting Compounds EDCs in the Environment." In Transformation Products of Emerging Contaminants in the Environment. John Wiley and Sons Ltd, 2014. http://dx.doi.org/10.1002/9781118339558.ch22.
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Senesi, Nicola, and Elisabetta Loffredo. "The Role of Soil Organic Matter in Limiting Organic Pollution in Soils with Focus on Endocrine Disruptor Compounds." In The Role of Ecological Chemistry in Pollution Research and Sustainable Development. Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2903-4_18.
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Giesy, John P., K. Kannan, Alan L. Blankenship, Paul D. Jones, and J. L. Newsted. "Toxicology of PCBs and Related Compounds." In Endocrine Disruption. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195137491.003.0013.
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Abstract Polychlorinated biphenyls (PCBs) are among the most studied environmental contaminants. PCBs have the potential to modulate the endocrine system through a number of mechanisms and have been designated as endocrine-disrupting com pounds (EDCs) by a number of researchers and government agencies (Kendall et al., 1998; Knobil et al., 1999). Effects can be either direct or indirect. Here we present evidence that PCBs are EDCs.
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Yazar, Selma. "Endocrine Disruptors and Infertility." In Poisoning - The Toxicity of Environmental Pollutants [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104403.
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Endocrine-disrupting chemicals (EDC) are known to interfere the body’s endocrine system. EDCs can also be considered as industrial chemicals namely pesticides, cleaning materials, plastics, heavy metals, and cosmetics. Most of these compounds particularly at low doses, occurring in complex mixtures, have been reported as emerging contaminants. EDCs are currently present in environment (water, diet, food contact materials, personal care products, etc). The adverse effects of exposure to EDCs have already been extensively described such as infertility, cancers, disrupted thyroid function, neurological disorders, obesity, metabolic syndrome. EDCs may be blamed for increasing the human reproductive disorders especially infertility. This is a serious public health problem that should not be ignored. This chapter aims to summarize the major scientific advances in human infertility associated with exposure to EDCs with epidemiological and experimental evidence. The chemicals covered in this chapter are heavy metals (lead), pesticides (pyrethroids), and cosmetics (UV filters).
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Orchinik, Miles, and Catherine Propper. "Hormone Action on Receptors." In Endocrine Disruption. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195137491.003.0002.
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Abstract The physiological actions of hormones are mediated by receptors, but the specificity of receptors is rarely absolute. Hormone receptors may bind endogenous compounds other than their principal cognate ligands and may also bind exogenous compounds. Therefore, a fraction of exogenous pharmaceuticals, as well as agricultural or industrial chemicals released into the environment, may bind to hormone receptors. A major subset of environmental endocrine disrupting chemicals (EDCs) exert their actions by binding to hormone receptors.
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Carr, James A., and David O. Norris. "Introduction to Part III." In Endocrine Disruption. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195137491.003.0011.
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Abstract Endocrine-disrupting chemicals (EDCs) come from many different types of chemical classes, including pesticides, synthetic hormones, natural plant compounds, chemicals used in the plastics industry, and waste products of the aerospace industry such as perchlorate. In part III of this volume, several experts in the fields of toxicology and endocrinology discuss the ability of these various classes of contaminants to disrupt the endocrine system and affect the health of humans and wildlife.
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Gupta, Priya, Archisman Mahapatra, Anjali Suman, and Rahul Kumar Singh. "Effect of Endocrine Disrupting Chemicals on HPG Axis: A Reproductive Endocrine Homeostasis." In Hot Topics in Endocrinology and Metabolism [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96330.
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The hypothalamic–pituitary-gonadal (HPG) axis plays a crucial and integrative role in the mammalian endocrine regulation to maintain homeostasis. The HPG axis is primarily responsible for governing all the hormonal events related to reproductive activity. Endocrine-disrupting chemicals (EDCs) comprise a diverse group of naturally occurring and synthetic compounds that mimic and interfere with the endogenous chemical hormones. Epidemiological investigations have shown increasing evidence of altered development and detrimental effects on reproductive health during the past 50 years associated with endocrine disruptors affecting the HPG axis. The pleiotropic harmful effects of EDCs act through hormone-dependent downstream signaling pathways responsible for gonad development either through direct interaction with steroid hormone receptor or via epigenetic regulation. Hence, this chapter summarizes the biological plausibility of EDCs exposure and elucidates the mechanism of action underlying EDCs affecting the regulatory circuits of the mammalian HPG axis and reproductive function.
Conference papers on the topic "Endocrine disruptor compounds (EDCs)"
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Gonza´lez, Camille, Anai´s Va´zquez, Angel Morales, Liz Di´az, Carlos R. Cabrera, and Kai Griebenow. "Development of a Peroxidase Biosensor for the Detection of Endocrine Disrupting Chemicals (EDCs)." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13059.
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Endocrine disruptor compounds are able to mimic or antagonize the effects of endogenous hormones. Phenolic compounds are one of the most abundant classes of endocrine disruptors due to their presence in a broad range of chemical manufacturing processes. The detection of such compounds in food, medicine, and the environment (i.e., water) is crucial to ensure their quality. To prevent the noxious effects of endocrine disruptors an efficient monitoring system is required in order for immediate remediation to be activated. The long-term goal of the project is to develop a robust and stable amperometric enzyme based biosensor able to determine the concentration of phenolic endocrine disruptors. This type of biosensor can be useful to monitor endocrine distruptors in biological fluids and environmental samples as for example the spacecraft drinking water, to ensure the health of the astronauts in space.
Reports on the topic "Endocrine disruptor compounds (EDCs)"
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Belkin, Shimshon, Sylvia Daunert, and Mona Wells. Whole-Cell Biosensor Panel for Agricultural Endocrine Disruptors. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696542.bard.
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Objectives: The overall objective as defined in the approved proposal was the development of a whole-cell sensor panel for the detection of endocrine disruption activities of agriculturally relevant chemicals. To achieve this goal several specific objectives were outlined: (a) The development of new genetically engineered wholecell sensor strains; (b) the combination of multiple strains into a single sensor panel to effect multiple response modes; (c) development of a computerized algorithm to analyze the panel responses; (d) laboratory testing and calibration; (e) field testing. In the course of the project, mostly due to the change in the US partner, three modifications were introduced to the original objectives: (a) the scope of the project was expanded to include pharmaceuticals (with a focus on antibiotics) in addition to endocrine disrupting chemicals, (b) the computerized algorithm was not fully developed and (c) the field test was not carried out. Background: Chemical agents, such as pesticides applied at inappropriate levels, may compromise water quality or contaminate soils and hence threaten human populations. In recent years, two classes of compounds have been increasingly implicated as emerging risks in agriculturally-related pollution: endocrine disrupting compounds (EDCs) and pharmaceuticals. The latter group may reach the environment by the use of wastewater effluents, whereas many pesticides have been implicated as EDCs. Both groups pose a threat in proportion to their bioavailability, since that which is biounavailable or can be rendered so is a priori not a threat; bioavailability, in turn, is mediated by complex matrices such as soils. Genetically engineered biosensor bacteria hold great promise for sensing bioavailability because the sensor is a live soil- and water-compatible organism with biological response dynamics, and because its response can be genetically “tailored” to report on general toxicity, on bioavailability, and on the presence of specific classes of toxicants. In the present project we have developed a bacterial-based sensor panel incorporating multiple strains of genetically engineered biosensors for the purpose of detecting different types of biological effects. The overall objective as defined in the approved proposal was the development of a whole-cell sensor panel for the detection of endocrine disruption activities of agriculturally relevant chemicals. To achieve this goal several specific objectives were outlined: (a) The development of new genetically engineered wholecell sensor strains; (b) the combination of multiple strains into a single sensor panel to effect multiple response modes; (c) development of a computerized algorithm to analyze the panel responses; (d) laboratory testing and calibration; (e) field testing. In the course of the project, mostly due to the change in the US partner, three modifications were introduced to the original objectives: (a) the scope of the project was expanded to include pharmaceuticals (with a focus on antibiotics) in addition to endocrine disrupting chemicals, (b) the computerized algorithm was not fully developed and (c) the field test was not carried out. Major achievements: (a) construction of innovative bacterial sensor strains for accurate and sensitive detection of agriculturally-relevant pollutants, with a focus on endocrine disrupting compounds (UK and HUJ) and antibiotics (HUJ); (b) optimization of methods for long-term preservation of the reporter bacteria, either by direct deposition on solid surfaces (HUJ) or by the construction of spore-forming Bacillus-based sensors (UK); (c) partial development of a computerized algorithm for the analysis of sensor panel responses. Implications: The sensor panel developed in the course of the project was shown to be applicable for the detection of a broad range of antibiotics and EDCs. Following a suitable development phase, the panel will be ready for testing in an agricultural environment, as an innovative tool for assessing the environmental impacts of EDCs and pharmaceuticals. Furthermore, while the current study relates directly to issues of water quality and soil health, its implications are much broader, with potential uses is risk-based assessment related to the clinical, pharmaceutical, and chemical industries as well as to homeland security.