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1

Esin, O. R., A. I. Mashtakova, and R. G. Esin. "GABAergic system – physiological role and clinical significance." Meditsinskiy sovet = Medical Council, no. 3 (April 12, 2025): 118–26. https://doi.org/10.21518/ms2025-106.

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This work presents a review of the literature using the elibrary.ru, CyberLeninka, PubMed, Scopus and Google Scholar databases with the key terms “Gamma-aminobutyric acid (GABA)”, “GABA agonists”, “GABA antagonists”, “GABA pathophysiology”, “children and adolescents”. The information obtained was analyzed, systematized and presented in three sections: general aspects of GABA, pathophysiology of GABA and GABAergic pharmacology and therapy. Currently, three types of GABA receptors have been identified: two fast-acting GABA-A and GABA-C and one slow-acting GABA-B. GABA is a neurotransmitter and n
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2

Moon, Myung-Sang, Ki-Tae Kwon, Chang-Won Ha, Sung-Soo Kim, Sung Sim Kim, and Hanlim Moon. "BONE HISTOLOGY OF PATIENTS WITH ALENDRONATE-MEDIATED FRACTURED BONE — A NEW ENTITY OF ATYPICAL OSTEOMALACIA." Journal of Musculoskeletal Research 17, no. 03 (2014): 1450011. http://dx.doi.org/10.1142/s0218957714500110.

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Based on the pharmaco-physiology of the aminobisphosphonates, it could be speculated that bisphosphonates could induce not only the osteopetrotic bone disease because of their selective suppression of osteoclastic activity, but also could affect directly or indirectly the endocrine system, local factors, and also the bone metabolic turnover. Consequently, the bone fragility could be rather produced by long-term aminobisphosphonate therapy. Bisphosphonate-mediated bone disease was labeled by Odvina et al. in 2005 [Odvina CV, Zerwerth JE, Rao DS et al. Severely suppressed bone turnover; a potent
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Shih, Ming-Chi, Sergio Daniel Simon, Zhiming Jin, et al. "Efficient Synthesis of Glutamate Peptide-Estradiol Conjugate for Imaging Estrogen Receptor-Positive Diseases." BioMed Research International 2018 (September 25, 2018): 1–14. http://dx.doi.org/10.1155/2018/5208964.

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Molecular imaging of estrogen receptor-positive (ER+) pathway-activated system serves the basis of ER+ disease management such as cancers and endometriosis. ER+ patients have better response to endocrine therapy and survive twice as long as negative ER patients. However, tumor resistance resulting from clinical used aromatase inhibitors and antiestrogens is unpredictable. Radiolabeled ER+ ligand could quantify ER+ tissue uptake which helps to stage and restage of the cancer as well as endometriosis. The differential diagnosis of ER+ lesions by using a labeled ligand helps to select the patient
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4

Panova, Alexandra V., Daria V. Goliudsova, and Sergey L. Kiselev. "The prospect of pluripotent stem cells for diabetes mellitus treatment." World Journal of Personalized Medicine 1, no. 1 (2017): 13–17. http://dx.doi.org/10.14341/wjpm9297.

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Treatment options are limited for many diseases including diabetes, cancer and neurological and, many patients do not receive adequate therapy. New chemical entities largely developed within the BioPharma industry are not sufficient to satisfy patient’s needs. New gene and modified cell constructs were developed in academia and are expected on the market recently. This review presents describes somatic cells reprogramming technology and its application for the new drug development. We then summarize the progress made in genome editing and its application to cure monogenic hereditary disorders
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Orlyk, O. S., and A. V. Garnytska. "Endocrine side effects of immunotherapeutic drugs." Infusion & Chemotherapy, no. 3 (September 29, 2023): 43–48. http://dx.doi.org/10.32902/2663-0338-2023-3-43-48.

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BACKGROUND. Immunotherapy is an innovative approach to treatment that is changing the paradigm in oncology and is achieving significant results in the fight against malignant tumors including leukemia, melanoma, lung cancer, kidney cancer and many others. This treatment uses the power of the body’s immune system to fight cancer cells. Immunotherapy can lead to long-term remission or even complete disappearance of tumors in patients with certain types of cancer. The success of therapy depends on many factors, including the type of cancer and individual patient characteristics. As with any treat
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Palibrk, Ivan, Jelena Velickovic, Vesna Pantic-Palibrk, Vladimir Arsenijevic, Biljana Tanovic, and Djordje Ugrinovic. "Preoperative preparation for patients with nutritional disorders." Acta chirurgica Iugoslavica 58, no. 2 (2011): 163–68. http://dx.doi.org/10.2298/aci1102163p.

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Eating disorders are very common today. An increasing number of patients that undergo anesthesia and surgery have some nutritional disorder. These disorders are very versatile starting from obesity to anorexia. Significant changes in all organ systems are present. These pathophysiological changes are increased with the duration of the disease. There are many changes in the functioning of the cardiovascular system in all these diseases and there are significant. Respiratory and ventilatory functions are changed too. There are also many endocrine disorders. As a final result, there are many seri
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7

Verbovoy, A. F., and Yu A. Dolgikh. "Hypothyroidism in a physician’s practice: difficulties of diagnostics and treatment." Medical Council, no. 21 (January 28, 2020): 206–12. http://dx.doi.org/10.21518/2079-701x-2019-21-206-212.

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Hypothyroidism is the most common endocrine disease after diabetes mellitus. Its frequency depends on age, sex and iodine intake. The highest prevalence of hypothyroidism is observed in older women. Chronic autoimmune thyroiditis is the most common cause of this condition. The peculiarity of hypothyroidism is an erased clinical picture, diversity and nonspecific symptoms. This makes it difficult to diagnose the disease, leads to an erroneous diagnosis and later detection of thyroid insufficiency. This article discusses the various «masks» of hypothyroidism and peculiarities of clinical manifes
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8

Verbovoy, A. F., N. I. Verbovaya, and Yu A. Dolgikh. "Symbiosis of cardiology and endocrinology." Meditsinskiy sovet = Medical Council, no. 14 (October 15, 2020): 80–89. http://dx.doi.org/10.21518/2079-701x-2020-14-80-89.

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In medical practice, there are often patients who have several diseases at once, both pathogenetically related to each other and not related. The article discusses endocrine diseases in which there are manifestations from the cardiovascular system - disorders of carbohydrate metabolism, pathology of the thyroid gland, adrenal glands and acromegaly. These diseases reduce the quality of life of patients and increase the risks of cardiovascular complications. The article also discusses the features of cardiovascular manifestations in these diseases and indications for differential diagnosis. Type
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9

Zelinska, N. B., N. G. Rudenko, E. V. Globa, O. V. Rudenko, К. Grishchenko, and Y. S. Kavetska. "Diseases of the endocrine system in children in Ukraine and the provision of specialized care to pediatric patients in 2020." Ukrainian Journal of Pediatric Endocrinology, no. 2 (July 16, 2021): 4–14. http://dx.doi.org/10.30978/ujpe2021-2-4.

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The articles provide information and analysis of statistical indicators on the state of endocrinological care for children in 2020 in general in Ukraine and in some regions, their dynamics for 2014—2020. Providing data on staffing of the pediatric endocrinology service; the state of inpatient care for children with endocrine diseases; disability due to endocrine pathology, which has been carried out in recent years, is constantly growing, in particular diabetes, hypothyroidism and others; diseases and prevalence of malignant diseases of the endocrine glands in children. It is also possible to
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10

Sienicka, Agnieszka, Krzysztof Kubasik, and Agata Pisula. "The Glucagon-Like Peptide-1 Analogues therapy in the non-diabetic patients." Prospects in Pharmaceutical Sciences 21, no. 1 (2023): 9–14. http://dx.doi.org/10.56782/pps.127.

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Glucagon like peptide-1 (GLP-1) receptor agonists are a group of hypoglycemic drugs that are used primarily to treat type 2 diabetes both as monotherapy and in combination with other antidiabetic drugs. In contrast to most hypoglycemic drugs, GLP-1 receptor agonists not only do not cause weight gain, but can even lead to weight reduction. This is why they are recently also increasingly used in the treatment of obesity in patients without type 2 diabetes. Current research indicate that liraglutide and semaglutide are effective and safe methods of treatment for overweight and obesity in patients
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Niewiadomska, Ewa, Beata Łabuz-Roszak, Piotr Pawłowski, and Agata Wypych-Ślusarska. "The Physical and Mental Well-Being of Medical Doctors in the Silesian Voivodeship." International Journal of Environmental Research and Public Health 19, no. 20 (2022): 13410. http://dx.doi.org/10.3390/ijerph192013410.

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Physical and mental well-being are important determinants of medical doctors’ lives, including their professional activity, which has a direct impact on the health and lives of patients. The aim of the study was to assess the health condition of medical doctors from the Silesian Voivodeship. The physical health condition, including the prevalence of chronic diseases, drug therapy, and pro-health activities, was assessed. Data on mental health according to the HADS scale (hospital anxiety and depression scale) referred to the selected socio-economic and professional aspects of life, as well as
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12

Dynnik, V. O., N. V. Bagatska, O. O. Dynnik, O. G. Verchoshanova, and H. O. Havenko. "Comorbid pathology issues in pediatric gynecology." Modern pediatrics. Ukraine, no. 8(128) (December 28, 2022): 32–36. http://dx.doi.org/10.15574/sp.2022.128.32.

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The problems of diagnosis, therapeutic tactics and medical prognosis in comorbid, polymorbid pathology stand out among the most actual problems of modern health care. Purpose - to study the frequency and nature of comorbid conditions in patients with pubertal abnormal uterine bleeding (PAUB). Materials and methods. The study included 342 girls aged 11-17 suffering from PAUB. All patients were examined by a multidisciplinary team of doctors. Results. It has been shown that menstrual irregularities are combined with other somatic, mental and endocrine pathologies in the vast majority of patients
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13

Manasova, Z. Sh, N. S. Andriutsa, A. V. Ershov, and S. V. Yureneva. "Modern methods of correction of age-related changes in the female body." Plastic Surgery and Aesthetic Medicine, no. 1 (March 5, 2025): 90. https://doi.org/10.17116/plast.hirurgia202501190.

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The article is devoted to the study of the processes occurring in the female body during the extinction of reproductive function, characterized by physical, endocrine, and psychological changes that negatively affect the quality of life. The role of the pineal gland hormone melatonin in the development of age-related changes in the body is reflected. The prospects of using a drug based on Pineamine polypeptides and modern laser therapy methods in the treatment of pathological conditions associated with hormonal imbalance due to age-related changes in the reproductive system or diseases accompa
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Azhar, Mirrah Nisa, Farrah Shafeera Ibrahim, and Naleena Devi Muniandy. "Antidiabetic Effect of Piper Sarmentosum: A Systematic Review." HEALTH AND WELLNESS II 18, s15 (2022): 341–48. http://dx.doi.org/10.47836/mjmhs.18.s15.46.

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Introduction: Diabetes mellitus (DM) is an endocrine, metabolic syndrome and has reached pandemic proportions worldwide. The multifactorial pathology results in the patient to including lifelong drug therapy for treatment. Alternative medicines such as traditional remedies using plant herbs to treat various diseases are common in most countries. Piper sarmentosum extracts have been as a traditional medicine to treat various diseases. The plant has abundant phytochemical properties such as alkaloids and flavonoids exhibiting pharmacological activities such as antidiabetic effects, antioxidant,
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15

Chernova, T. M., V. N. Timchenko, E. V. Barakina, et al. "Outcome of COVID-19 in children: results of a 12-month follow-up." Journal Infectology 14, no. 2 (2022): 96–106. http://dx.doi.org/10.22625/2072-6732-2022-14-2-96-106.

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At present, there are isolated data on the clinical outcomes of COVID-19 in children, especially those who have experienced asymptomatic and mild forms of infection.Purpose: to analyze the nature and frequency of postCOVID symptoms in children during 12 months. after recovery.Materials and methods. The influence of demographic indicators, premorbid background, severity of infection and therapy in the acute period of the disease on the nature and frequency of symptoms in 1079 children who underwent laboratory-confirmed COVID-19 was studied. The results are presented with proportions (%) and cal
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16

Slaughter, Richard L., Steven R. Erickson, and Peter A. Thomson. "Clinical Interventions Provided by Doctor of Pharmacy Students." Annals of Pharmacotherapy 28, no. 5 (1994): 665–70. http://dx.doi.org/10.1177/106002809402800519.

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OBJECTIVE: To assess the types, perceived benefit, and cost impact of the interactions provided by two-year post-B.S. Pharm.D. students on clerkship rotations. DESIGN: Information was obtained through voluntary reporting by students on a standardized data collection form. Cost analysis and peer review were performed on a subset of interventions. SETTING: The setting of the study included hospital clerkship sites (general medicine and specialty rotations) and an ambulatory care site (general medicine). PARTICIPANTS: Six second-year Pharm.D. students. RESULTS: Reports that were completed totaled
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17

Gladenko, S. E. "The effect of hormone therapy on the condition of the mammary glands in women with menstrual disorders of endocrine origin." Reproductive health of woman 5 (December 31, 2020): 11–15. http://dx.doi.org/10.30841/2708-8731.5.2021.224481.

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The objective: to study the effect of stimulating hormone therapy on the condition of the mammary glands depending on the initial endocrine status of women with menstrual disorders in the background and after ovulation stimulation.Materials and methods. The study selected a group of 130 patients (n=130) of reproductive age (mean age 27±2,3 years), which by the nature of menstrual disorders are divided into 2 subgroups: 1 subgroup (n=57) – women with regular menstrual rhythm and insufficiency of the luteal phase (ILP), 2 subgroup (n=73) – women with secondary amenorrhea and oligomenorrhea on th
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18

Esedovna, Asiyat E., and Albina Yu Islamova. "Magneto-infrared-light-laser therapy and ozone therapy in the complex treatment of salpingo-oophoritis after medical abortion." V.F.Snegirev Archives of Obstetrics and Gynecology 11, no. 1 (2024): 77–82. http://dx.doi.org/10.17816/2313-8726-2024-11-1-77-82.

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Background. Complications following artificial abortion can lead to reproductive dysfunction and gynecological diseases, endocrine disorders, infertility, and miscarriage. One of the most important tasks of practical healthcare is the introduction of safer abortions and an adequate rehabilitation system, including early, as well as ultrasound, diagnostics of emerging complications, into the practice of obstetricians and gynecologists.
 Materials and methods. The study included 124 female patients (average age, 34.8+1.7 years) who applied for pregnancy termination in the first trimester. T
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19

Erlandsson, AC, LG Bladh, P. Stierna, et al. "Herpes simplex virus type 1 infection and glucocorticoid treatment regulate viral yield, glucocorticoid receptor and NF-kappaB levels." Journal of Endocrinology 175, no. 1 (2002): 165–76. http://dx.doi.org/10.1677/joe.0.1750165.

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The interplay between the endocrine and immune systems has come into focus in recent years with the insight that endocrine parameters may affect susceptibility to both auto-immune and infectious diseases. Our interest in immunoendocrine regulation led us to investigate the effects of glucocorticoids on Herpes simplex virus type 1 (HSV-1) infections. Glucocorticoids used to treat inflammatory conditions are not yet recommended for HSV-1 therapy, since they have been reported to prolong viral shedding both in vivo and in vitro. Here we report that glucocorticoids did not alter the viral yield in
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20

Ayzyatulov, R. "CLINICAL DIAGNOSTIC CRITERIA AND COMPLEX THERAPY TELOGENE ALOPECIA IN WOMEN." Dermatology and Venerology, no. 3 (2023): 18–23. http://dx.doi.org/10.33743/2308-1066-2023-3-18-23.

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Objective. Increase the effectiveness of complex therapy for patients with telogen alopecia with simultaneous use of the drug «Volvit tablets» (biotin 5 mg) inside and «Volvit intensive care shampoo» with biotin externally. Materials and methods. Patients with telogen alopecia, aged 22 to 40 years, who had complaints and a history of the disease (time of onset of increased hair loss, connection of baldness with stress, medication, viral infection, etc.) were under observation. The main diagnostic measures included: pull test, dermatoscopy, trichoscopy, trichogram, laboratory tests (general blo
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Nicoletti, Alberto, Federica Vitale, Mattia Paratore, et al. "Neuropancreatology: The Nervous System and Pain Management in Pancreatic Diseases." Life 14, no. 3 (2024): 299. http://dx.doi.org/10.3390/life14030299.

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The intricate network of the pancreatic nervous system plays a fundamental role in physiologic functions of the endocrine and exocrine pancreas. Several pancreatic diseases affect the normal functionality of the pancreatic nervous system. This chronic derangement leads to anatomical alterations, such as neural hypertrophy and increased nerve density. Perineural invasion is a prominent feature of pancreatic cancer, contributing to cancer progression and metastasis. Despite the fact that these pathogenic mechanisms are still incompletely studied and understood, the constant occurrence of these a
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Faria, Rúben, Prisca Boisguérin, Ângela Sousa, and Diana Costa. "Delivery Systems for Mitochondrial Gene Therapy: A Review." Pharmaceutics 15, no. 2 (2023): 572. http://dx.doi.org/10.3390/pharmaceutics15020572.

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Mitochondria are membrane-bound cellular organelles of high relevance responsible for the chemical energy production used in most of the biochemical reactions of cells. Mitochondria have their own genome, the mitochondrial DNA (mtDNA). Inherited solely from the mother, this genome is quite susceptible to mutations, mainly due to the absence of an effective repair system. Mutations in mtDNA are associated with endocrine, metabolic, neurodegenerative diseases, and even cancer. Currently, therapeutic approaches are based on the administration of a set of drugs to alleviate the symptoms of patient
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S., E. Gladenko. "The effect of hormone therapy on the condition of the mammary glands in women with menstrual disorders of endocrine origin." Reproductive health of woman 5 (December 31, 2020): 11–15. https://doi.org/10.30841/2708-8731.5.2021.224481.

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<strong>The objective:</strong>&nbsp;to study the effect of stimulating hormone therapy on the condition of the mammary glands depending on the initial endocrine status of women with menstrual disorders in the background and after ovulation stimulation. <strong>Materials and methods.</strong>&nbsp;The study selected a group of 130 patients (n=130) of reproductive age (mean age 27&plusmn;2,3 years), which by the nature of menstrual disorders are divided into 2 subgroups: 1 subgroup (n=57) &ndash; women with regular menstrual rhythm and insufficiency of the luteal phase (ILP), 2 subgroup (n=73)
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24

Saranskaya, Ya E., L. M. Kiseleva, and A. A. Sachek. "Comorbidity and multimorbidity in patients with chronic hepatitis C." Journal Infectology 14, no. 4 (2022): 88–93. http://dx.doi.org/10.22625/2072-6732-2022-14-4-88-93.

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The aim of the study was to analyze comorbidity in patients who underwent a course of antiviral therapy for chronic hepatitis C with direct antiviral drugs.Materials and methods: 288 patients diagnosed with chronic hepatitis C with stages of liver fibrosis from F1 to F4 according to the METAVIR scale, various genotypes, who underwent antiviral therapy with direct antiviral drugs in the period from 2018 to 2021, were under observation, with an analysis of comorbid and multimorbid diseases.Results of the study: most often in these patients, regardless of gender and antiviral therapy regimen, les
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Bharthi, Vandana, N. Kavya, M. N. Shubhashree, and Sulochana Bhat. "Herbal approach to management of thyroid disease - a review." Journal of Ayurvedic and Herbal Medicine 3, no. 1 (2017): 48–52. http://dx.doi.org/10.31254/jahm.2017.3109.

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Endocrine disorders are common in India of which the thyroid disorders represent a major subset. Thyroid dysfunction prevalence is rising at an alarming rate in Indian population. Hypothyroidism and hyperthyroidism constitute the maximum percentage of thyroid diseases in India. Hormone replacement therapy has been a standard approach to thyroid dysfunction. However, herbal approach to treatment of thyroid dysfunction is gaining popularity as it is said to be equally effective, safe and devoid of any side effects. Ayurvedic system of medicine has been very effective in maintenance and treatment
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Kyselova, K. E., and L. I. Vyshnevska. "Perspectives of essential oils usage in dermatological medicines." Annals of Mechnikov Institute, no. 1 (March 11, 2023): 54–61. https://doi.org/10.5281/zenodo.7721539.

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<strong>Aim of work</strong>. Theoretical substantiation of the effectiveness of essential oils&rsquo; use as APIs in medicinal preparations for the treatment of dermatological diseases.&nbsp;<strong>Materials and methods</strong>. In the course of the research, data from scientific literary sources was analyzed and the following methods were used: experimental and theoretical, generalization, analysis of statistical data.&nbsp;<strong>Results and discussion. </strong>Analysis of scientific studies of the antibacterial activity of essential oils has shown the effectiveness of using essential o
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Зейналова, Х. П., Н. Э. Ахундова, А. Дж. Исмайлова, and Т. Ф. Джафарова. "Drug Correction of Cognitive and Psycho-Emotional Disorders in Menopausal Women." Репродуктивное здоровье. Восточная Европа 13, no. 4 (2023): 358–68. http://dx.doi.org/10.34883/pi.2023.13.4.005.

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В настоящее время наблюдается увеличение численности старшей возрастной группы, и это определяет возникновение новых вопросов, связанных с возраст-ассоциированными заболеваниями. Выявлена прямая связь между частотой жалоб на изменение когнитивной активности и началом нарушения менструальной функции, т. е. старением репродуктивной системы, что, в свою очередь, приводит к снижению уровня половых гормонов. Определяется зависимость между соотношением эстрогенов, прогестерона, андрогенов и когнитивной активностью женщин. Современные теории «здоровых клеток» и «эуэстрогении» объясняют влияние дополн
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Luzik, Yuliya V., Sapiyat G. Isaeva, Evgeniya A. Svidinskaya, Mikhail B. Ageev, and Elena A. Sosnova. "Menopausal hormone therapy and Alzheimer’s disease: A literature review." V.F.Snegirev Archives of Obstetrics and Gynecology 11, no. 1 (2024): 25–34. http://dx.doi.org/10.17816/2313-8726-2024-11-1-25-34.

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This paper presents a review of the current literature on the possible relationship between menopausal hormone therapy and Alzheimer’s disease. Increasing life expectancy in modern society is steadily leading to health problems in older women. Approximately 46.8 million people worldwide currently have cognitive disorders, and 2/3 of them are women. At the age of ≥65 years, every sixth woman and every eleventh man experience a form of higher nervous system pathologies. Older people are most often diagnosed with Alzheimer’s disease. It is a neurodegenerative disease that leads to problems with m
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Grigoryeva, N. N., and G. A. Airapetov. "Mechanisms of musculoskeletal consequences of COVID-19." Genij Ortopedii 30, no. 1 (2024): 153–62. http://dx.doi.org/10.18019/1028-4427-2024-30-1-153-162.

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Introduction A coronavirus, SARS-CoV-2, called COVID-19 by the WHO has caused a pandemic of respiratory illness killed more than 6 million people. The severe infection has a significant negative impact on the entire musculoskeletal system.The objective was to summarize literature data on the mechanisms of the condition and identify musculoskeletal symptoms of COVID-19.Material and methods An internet search of PubMed, MedLine and eLIBRARY library databases using the search terms: COVID-19, aseptic osteonecrosis, post-COVID-19 syndrome, arthropathy, musculoskeletal system, spondylitis, osteopor
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Zhulidova, A. U., and I. I. Dubinina. "Acromegaly and comorbid conditions. New possibilities of diagnosis and treatment (literature review)." I.P. Pavlov Russian Medical Biological Herald 26, no. 1 (2018): 117–32. http://dx.doi.org/10.23888/pavlovj20181117-132.

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Based on the data published in Russian and foreign reference sources, an analysis of clinical-hormonal peculiarities, modern methods of treatment of acromegaly combined with polyendocrinopathies (diabetes mellitus, diffuse and nodular goiter, hypocorticoidism) and cardiovascular diseases was conducted. According to different authors, a decline in the quality and duration of life of patients is associated with significant changes in the endocrine system caused by contrainsular and stimulating effect of somatotropic hormone (STH) and insulin-like growth factor 1 (IGF-1) on organs and tissues. Se
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Zhulidova, A. U., and I. I. Dubinina. "Acromegaly and comorbid conditions. New possibilities of diagnosis and treatment (literature review)." I.P. Pavlov Russian Medical Biological Herald 26, no. 1 (2018): 117–32. http://dx.doi.org/10.23888/pavlovj2018261117-132.

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Based on the data published in Russian and foreign reference sources, an analysis of clinical-hormonal peculiarities, modern methods of treatment of acromegaly combined with polyendocrinopathies (diabetes mellitus, diffuse and nodular goiter, hypocorticoidism) and cardiovascular diseases was conducted. According to different authors, a decline in the quality and duration of life of patients is associated with significant changes in the endocrine system caused by contrainsular and stimulating effect of somatotropic hormone (STH) and insulin-like growth factor 1 (IGF-1) on organs and tissues. Se
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32

O., O. Berestovyy. "The ovulation stimulation in women with breast pathology and menstrual disorders of endocrine genesis." Reproductive health of woman 4 (December 30, 2020): 31–35. https://doi.org/10.30841/2708-8731.4.2020.222142.

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<strong>The objective</strong><strong>.</strong>&nbsp;To analyze the results of ovulation stimulation and restoration of reproductive function in women with breast pathology with endocrine infertility. <strong>Materials and methods.</strong>&nbsp;For the study, a group of 130 patients (n=130) of reproductive age (mean age 27&plusmn;2,3 years) was selected, who were divided into 2 subgroups by the nature of menstrual dysfunction: 1 subgroup (n=57) &ndash; women with a regular rhythm of the menstrual cycle and insufficiency of the luteal phase, 2 subgroup (n=73) &ndash; women with secondary amen
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33

Aloisi, Anna Maria. "Opioid-Induced Hypogonadism: Why and How to Treat It." July 2012 3S;15, no. 3S;7 (2012): ES111—ES118. http://dx.doi.org/10.36076/ppj.2012/15/es111.

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Background: Gonadal hormones are critical factors in modulating the experience of pain, as suggested by the several sex differences observed: women have a greater risk of many clinical pain conditions, and postoperative and procedural pain may be more severe in them than in men. A growing body of literature demonstrates the role of estrogen in the female pain experience, whereas less attention has been given to testosterone and its functions. Nevertheless, testosterone has an appreciable role in both women and men: adequate serum levels are required in males and females for libido and sexualit
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Semenova, N. V., I. M. Madaeva, and L. I. Kolesnikova. "Glutathione system activity in the blood of overweight postmenopausal women." Russian Clinical Laboratory Diagnostics 66, no. 10 (2021): 581–85. http://dx.doi.org/10.51620/0869-2084-2021-66-10-581-585.

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One of the important components of the antioxidant defense system is the glutathione system, the activity of which, when overweight, changes direction depending on gender and ethnicity. The results of studies involving overweight menopausal women are mixed. The study involved 61 postmenopausal women, who, after clinical and anamnestic examination, were divided into 2 groups: control (BMI = 19-24.9 kg / m2) and overweight group (BMI = 25-29.9 kg/m2). The use of hormone replacement therapy; the use of antioxidant drugs; diseases of endocrine genesis; exacerbation of chronic diseases; premature e
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35

Kovaleva, E. V., A. K. Eremkina, I. S. Maganeva, et al. "Review of clinical practice guidelines for hypoparathyroidism." Endocrine Surgery 18, no. 2 (2024): 4–22. http://dx.doi.org/10.14341/serg12950.

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Hypoparathyroidism is an endocrine disease characterized by reduced production of parathyroid hormone by the parathyroid glands or tissue resistance to its action. This is accompanied by disturbances in phosphorus-calcium metabolism.The main cause of hypoparathyroidism is damage or removal of the parathyroid glands during surgery on the neck organs. Autoimmune hypoparathyroidism is the second most common form of the disease, which occurs, as a rule, within the autoimmune polyglandular syndrome type 1.The development of chronic hypoparathyroidism of any etiology requires lifelong appointment of
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36

Shapovalov, KA, LA Shapovalova, NG Knyazeva, et al. "An Individual Rehabilitation and/or Habilitation Program for Children with Disabilities (IPRH)." Journal of Advanced Pediatrics and Child Health 7, no. 1 (2024): 007–12. http://dx.doi.org/10.29328/journal.japch.1001062.

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Introduction: The individual program of rehabilitation and (or) habilitation of children with disabilities (IPRH) is mandatory for execution by the relevant state authorities, local self-government bodies, as well as organizations regardless of organizational-legal forms and forms of ownership. Objective: To conduct a pilot analysis of the implementation of the IPRH contingent of patients of children with disabilities in an urban children’s clinic. Patients and methods: There were 366 reports on the implementation of measures provided for by an IPRH for a disabled person (disabled child) of 22
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37

Kaminskiy, V. V., and E. V. Prokopovych. "Alternative to hormonal and nonsteroid anti-inflammator means in the treatment of secondary dismarophone defined by adenomiosis." HEALTH OF WOMAN, no. 4(130) (May 30, 2018): 66–70. http://dx.doi.org/10.15574/hw.2018.130.66.

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Secondary dysmenorrhea or painful menstruation are observed in almost half of young women and significantly affect the quality of life, primarily in the emotional, psychic and communication spheres, and also often cause the loss of temporary work capacity. Secondary (organic) dysmenorrhea is caused by various pathological diseases in the pelvic organs (uterine leiomyoma, ovarian tumors, pelvic inflammatory processes, malformation of the genital organs, adhesive process in the small pelvis, etc.) and in particular adenomyosis (internal endometriosis). This disease, leads to disruption of reprod
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38

Jovandaric, Miljana Z., Stefan Dugalic, Sandra Babic, et al. "Programming Factors of Neonatal Intestinal Dysbiosis as a Cause of Disease." International Journal of Molecular Sciences 24, no. 6 (2023): 5723. http://dx.doi.org/10.3390/ijms24065723.

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The intestinal microbiota consists of trillions of bacteria, viruses, and fungi that achieve a perfect symbiosis with the host. They perform immunological, metabolic, and endocrine functions in the body. The microbiota is formed intrauterine. Dysbiosis is a microbiome disorder characterized by an imbalance in the composition of the microbiota, as well as changes in their functional and metabolic activities. The causes of dysbiosis include improper nutrition in pregnant women, hormone therapy, the use of drugs, especially antibiotics, and a lack of exposure to the mother’s vaginal microbiota du
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39

Davletbaeva, N. V., R. A. Sharipov, E. A. Daminov, R. N. Davletbaev, and T. E. Tyulkova. "Clinical and epidemiological features of the detection and course of the infectious disease tuberculosis depending on the presence of concomitant pathology." CARDIOMETRY, no. 29 (November 1, 2023): 74–79. http://dx.doi.org/10.18137/cardiometry.2023.29.7479.

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The article is devoted to the most pressing issues of studying the clinical and epidemiological features concerning the detection and course of tuberculosis infection in patients with concomitant pathologies. Such pathologies include cancer, diseases of the endocrine system, of the respiratory system (chronic bronchitis, pneumoconiosis), gastric ulcer, pathology of the urinary system, exhaustion due to insufficient nutrition, smoking. Using genetically engineered biological drugs (GEBPs) in practice reduces the activity of inflammatory phenomena due to suppression of the immune response, but i
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40

Gertsev, A. V., Yu N. Zakrevskii, and V. N. Ischuk. "Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level of neuropeptide-cytokine links of immune system in polymorbid cardiovascular pathology in presence of affective spectrum disorders in marine specialists in the Far North." Medical Immunology (Russia) 23, no. 3 (2021): 541–56. http://dx.doi.org/10.15789/1563-0625-evf-2160.

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Scientific medical literature has accumulated a lot of data suggesting most important components of coronary heart disease pathogenesis and hypertension to be complex triggering processes of neuro-immune and neuro-endocrine interactions. Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. As a rule, it results in remodeling of the vascu
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Biradar, Sujata, and Asha Anand. "AYURVED MANAGEMENT OF SECONDARY INFERTILITY - A CASE STUDY." International Ayurvedic Medical Journal 09, no. 3 (2021): 677–80. http://dx.doi.org/10.46607/2709032021.

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Infertility due to anovulatory cycles over recent years, has emerged as one of the most common health issues that many young women have been facing. Sedentary lifestyles with minimum physical activity, rising stress level and irregular sleep pattern are few of the reasons, according to many clinicians and health experts. PCOD is a common Endocrine disturbance affecting females of age group between 15-30 years. The disorder accounts for delayed periods, Infertility, obesity hirsutism and acne. According to modern science exact cause of disease is unknown. In Ayurveda all diseases of female repr
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Angelopoulos, N., V. Barbounis, S. Livadas, D. Kaltsas, and G. Tolis. "Effects of estrogen deprivation due to breast cancer treatment." Endocrine-Related Cancer 11, no. 3 (2004): 523–35. http://dx.doi.org/10.1677/erc.1.00783.

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Breast cancer is one of the main life-threatening diseases that a woman may have to face during her lifetime. The increasing incidence of breast neoplasia reported over the last few decades has led to widespread screening of women resulting in early diagnosis. One common but challenging question for most doctors, after the surgical excision of the lesion, is determination of the ideal adjuvant therapy for their patients for the achievement of maximum life expectancy with the best quality of life. Since the beginning of the last century, the knowledge that breast cancer arises from hormone-resp
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43

Zhan, Shi-Ping. "Necrolytic migratory erythema caused by pancreatic hyperglycemia with emphasis on therapeutic and prognosis: A case report." World Journal of Clinical Cases 12, no. 23 (2024): 5404–9. http://dx.doi.org/10.12998/wjcc.v12.i23.5404.

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BACKGROUND With the incidence of pancreatic diseases increasing year by year, pancreatic hyperglycemia, as one of the common complications, is gradually gaining attention for its impact on the skin health of patients. CASE SUMMARY This was the case of an elderly female with clinical manifestations of necrolytic migratory erythema, “three more and one less,” diabetes mellitus, hypertension, anemia, hypoproteinemia, and other syndromes, which had been misdiagnosed as eczema. Abdominal computed tomography showed a pancreatic caudal space-occupying lesion, and the magnetic resonance scanning of th
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Tymoshenko, Galyna. "Dynamics of Clinical Symptoms and Functional State of the Biliary System in Patients with Chronic Acalculous Cholecystitis on the background of Type 2 Diabetes Mellitus under the Influence of Complex Therapy." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 1 (2021): 138–44. http://dx.doi.org/10.26693/jmbs06.01.138.

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The urgent problem of modern medical science and practice is the rapid increase of comorbid pathology spreading among the population of the whole world. Among the nosological forms, which are quite often combined with each other, there are cardiovascular system, digestive tract and endocrine diseases, namely type 2 diabetes mellitus. Diseases of the biliary tract, in the form of chronic acalculous cholecystitis, occur in patients with type 2 diabetes more often than in its absence. There is no doubt that the combination of diseases of the gallbladder and type 2 diabetes significantly affects t
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45

Vashirkina, I. M., G. V. Smirnova, V. V. Pronin, M. V. Arzhakaeva, and O. V. Kabanov. "CARPAL TUNNEL SYNDROME: CONSERVATIVE AND SURGICAL TREATMENT." Vestnik of North-Eastern Federal University. Medical Sciences, no. 1 (March 31, 2025): 14–24. https://doi.org/10.25587/2587-5590-2025-1-14-24.

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Carpal tunnel syndrome is a common polyethological neuropathy of the peripheral nervous system characterized by compression of the median nerve in the carpal tunnel area. The disease is more common in middle-aged and elderly women, as well as in people whose professions involve intensive manual work, for example, engineers, programmers, medical professionals, seamstresses. The main risk factors for carpal tunnel syndrome include: old age (over 60 years), overweight (BMI &gt; 30 kg/m2), type 1 and type 2 diabetes mellitus, other endocrine disorders (acromegaly, myxedema, Bazedov’s disease), rhe
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46

Борисевич, М. В., К. О. Кальченко, and О. И. Быданов. "Late Effects of Cancer Therapy in Children with Rhabdomyosarcoma in Belarus." Гематология. Трансфузиология. Восточная Европа, no. 4 (December 29, 2021): 405–15. http://dx.doi.org/10.34883/pi.2021.7.4.001.

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За последние 20 лет успехи детских онкологов, связанные с увеличением показателя выживаемости, привели к растущему числу лиц трудоспособного возраста, излечившихся от злокачественного новообразования в детском возрасте. Цель исследования. Изучить негативное влияние противоопухолевого лечения у пациентов детского возраста с рабдомиосаркомой; определить время отдаленных последствий, связанных с сердечно-сосудистой и нервной системами. Материалы и методы. В исследование включено 62 пациента в возрасте от 8 до 33 лет, заболевших и излеченных от рабдомиосаркомы в возрасте до 18 лет. Все пациенты ле
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47

Karachentsev, A. N., P. V. Sergeev, and A. I. Matyushin. "Gestagens and heart." Problems of Endocrinology 42, no. 2 (1996): 42–45. http://dx.doi.org/10.14341/probl12030.

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The use of gestagen hormones (progestogens, progestogens, progestins) in modern medicine is mainly based on their effect on the reproductive sphere of the female body, including menstrual dysfunction (luteal phase of the cycle), contraception, pregnancy support, correction of hormonal homeostasis during menopause, antitumor activity in some hormone-dependent oncological diseases. The presence of antiandrogenic properties in a number of progestogens (C21-derivatives), which have found application as antihormonal therapy for certain endocrine diseases in women (hirsutism) and for malignant neopl
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48

Kotłowska, Alicja, and Piotr Szefer. "Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery." Current Medicinal Chemistry 26, no. 1 (2019): 29–45. http://dx.doi.org/10.2174/0929867324666171113120810.

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Background: Steroid hormones belong to a group of low-molecular weight compounds which are responsible for maintenance of various body functions, thus, their accurate assessment is crucial for evaluation of biosynthetic defects. The development of reliable methods allowing disease diagnosis is essential to improve early detection of various disorders connected with altered steroidogenesis. Currently, the field of metabolomics offers several improvements in terms of sensitivity and specificity of the diagnostic methods when opposed to classical diagnostic approaches. The combination of hyphenat
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49

Machowiec, Piotr Artur, Marcela Maksymowicz, Anna Korzeniowska, et al. "Integrative medicine - combination of conventional medicine and traditional herbal medicine may find its potential applications in the treatment of certain dermatological and endocrine diseases – review of the literature." Journal of Education, Health and Sport 34, no. 1 (2023): 130–39. http://dx.doi.org/10.12775/jehs.2023.34.01.011.

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Introduction and purpose&#x0D; &#x0D; Traditional Chinese herbal medicine is an integral component of a comprehensive healing system known as Traditional Chinese Medicine (TCM). Within TCM, herbs are utilized to rebalance the energy forces of Yin and Yang, which flow through imperceptible channels within the body with the aim of restoring energy equilibrium. It is important to acknowledge that herbs have the potential to exert significant effects on the body comparable to pharmaceutical drugs, and therefore, should be approached with equal caution and respect&#x0D; The aim of the study was to
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50

Balabolkin, M. I. "III All-Russian Congress of Endocrinologists." Problems of Endocrinology 42, no. 6 (1996): 41–43. http://dx.doi.org/10.14341/probl12061.

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The III All-Russian Congress of Endocrinologists was held in Moscow from June 4 to 7, 1996. The scientific program of the congress included almost all sections of endocrinology: diabetes mellitus, diseases of the hypothalamic-pituitary system, diseases of the thyroid and parathyroid glands, pathology of the adrenal glands and gonads. A separate symposium at the congress was devoted to endocrine pathology as a consequence of radiation disasters. The first plenary lecture at the congress was dedicated to the late complications of diabetes, which was presented by the president of the Russian Acad
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