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Relevant bibliographies by topics / Endocrine systems / Dissertations / Theses

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Dissertations / Theses on the topic 'Endocrine systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Hidayat, Egi. "On identification of endocrine systems." Licentiate thesis, Uppsala universitet, Avdelningen för systemteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-227630.

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System identification finds nowadays application in various areas of biomedical research as a tool of empiric mathematical modeling and model individualization. Hormone regulation is a classical example of biological feedback where control theories, in general, and system identification, in particular, are indispensable in unraveling the regulation mechanisms and explicating the complex dynamical phenomena arising in endocrine systems. The main function of endocrine feedback regulation is to maintain the hormone levels within a particular physiological range as well as to sustain an appropriat

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2

Sharma, Raju Prasad. "Integrative Systems Toxicology For Human Health." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/665621.

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Els disruptors endocrins (DE) són substàncies naturals o antropogèniques presents el ambient, aliments o productes de consum que poden alterar els equilibris hormonals en humans i animals i produir efectes adversos per a la salut fins i tot a dosis baixes. S'han desenvolupat nombrosos mètodes, sota l'orientació de la UE i OCD, amb l'objectiu de realitzar avaluacions de riscos quantitatius per a aquests substàncies, tanmateix, aquests mètodes encara no tenen la confiança en el nivell de seguretat per a l'exposició humana. La predicció quantitativa dels efectes adversos dels DE en la salut human

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3

Masutomi, Naoya. "Evaluation of endocrine active chemicals on endocrine/reproductive systems following transplacental and lactational exposure in rats." Kyoto University, 2004. http://hdl.handle.net/2433/147783.

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4

McKinlay, Rebecca. "Risk assessment of endocrine disrupting pesticides in biological systems." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5585.

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Endocrine Disrupting Chemicals (EDCs) are a diverse array of natural and manmade substances capable of interfering with hormonally mediated processes. They are particularly harmful to cells that are differentiating and dividing rapidly, can stimulate unwanted cell growth, and can interfere with normal epigenetic imprinting causing changes that in some instances are heritable. Due to their epigenetic effects and effects on tissue growth and development, organisms at certain life stages are more vulnerable than others and effects may manifest a long time after exposure. The risks posed to human

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5

Clarke, Neil. "Seasonal effects of treated sewage effluents upon the reproduction and development of European freshwater molluscs." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/4458.

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The most widespread evidence of environmental endocrine disruption in aquatic wildlife is from the feminising effects of oestrogenic endocrine disrupting compounds. However, very little is known of the effects of these chemicals (and others) upon freshwater molluscs found in our river and lakes. This thesis aimed at evaluating the effects of treated sewage effluent upon the reproductive and developmental cycle of a range of commonly found European freshwater gastropod molluscs. Initial mesocosm experiments were undertaken to test a range of mollusc species for their the suitability to the expe

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6

Chen, Chun. "Systems Biology Study of Breast Cancer Endocrine Response and Resistance." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51965.

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As a robust system, cells can wisely choose and switch between different signaling programs according to their differentiation stages and external environments. Cancer cells can hijack this plasticity to develop drug resistance. For example, breast cancers that are initially responsive to endocrine therapy often develop resistance robustly. This process is dynamically controlled by interactions of genes, proteins, RNAs and environmental factors at multiple scales. The complexity of this network cannot be understood by studying individual components in the cell. Systems biology focuses on the i

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7

Dalwai, Ebrahim. "Systems delays in the management of malignant breast disease." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20298.

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Centralised multidisciplinary management of breast cancer occurs in KwaZulu-Natal, South Africa and requires a diagnostic and staging pathway at the referring hospital. Delays in this pathway are unknown. This study, conducted at a referring hospital, R K Khan (RKK), quantifies and analyses these delays. A retrospective folder review included all patients with breast cancer diagnosed at RKK from January 2008 to January 2009. Data extraction included demographic data, time to diagnosis and initial staging using a standardised datasheet. Specific care steps were identified, namely delays to ini

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8

Mattsson, Per. "Pulse-modulated feedback in mathematical modeling and estimation of endocrine systems." Licentiate thesis, Uppsala universitet, Avdelningen för systemteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231908.

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The research field of systems biology has gained a lot of interest during the last decades. Systems biology can be seen as the systematic study of complex interactions in biological systems, mainly by methods from dynamical systems theory. This thesis mainly deals with the testosterone (Te) regulation in the human male, but techniques developed here might be useful for studying other parts of the endocrine system too. The contribution of the thesis can be divided into two parts: one covering mathematical models of Te regulation and another suggesting and validating identification techniques fo

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9

Ntshongontshi, Nomaphelo. "Molecularly imprinted polymer sensor systems for environmental estrogenic endocrine disrupting chemicals." University of the Western Cape, 2018. http://hdl.handle.net/11394/6241.

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Philosophiae Doctor - PhD (Chemistry)<br>There is growing concern on endocrine disrupting compounds (EDCs). The presence of drugs in water supplies was first realized in Germany in the early 1990s when environmental scientists discovered clofibric acid. Clofibric acid has the ability to lower cholesterol in ground water below a water treatment plant. Endocrine disrupting compounds can be defined as those chemicals with the ability to alter daily functioning of the endocrine system in living organisms. There are numerous molecules that are regarded or referred to as EDCs such as but not limited

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10

Bain, James Raymond. "Growth and function of transgenic endocrine cells on silanized surfaces /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7990.

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11

Azadbakht, Narges. "Stromal and epithelial changes in breast cancer following endocrine treatment." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/stromal-and-epithelial-changes-in-breast-cancer-following-endocrine-treatment(c6542eba-83e2-48de-a566-8f5eccd9a7b1).html.

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Anti-oestrogens and aromatase inhibitors are currently used as endocrine therapies in breast cancer. Despite the significant role that these treatments play in reducing breast cancer mortality, some patients may display intrinsic and acquired therapeutic resistance. Different mechanisms are thought to contribute to endocrine resistance in patients treated with anti-oestrogens such as tamoxifen and aromatase inhibitors such as letrozole. The importance of epithelial-stromal interactions in progression of breast tumour and the potential contribution of these interactions in resistance to tamoxif

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12

Giles, Hamilton. "Biotransformation potential of phytosterols in biological treatment systems under various redox conditions." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/48993.

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Phytosterols are naturally occurring compounds which regulate membrane fluidity and serve as hormone precursors in plants. They also have the potential to cause endocrine disturbances in aquatic animals at concentrations as low as 10 µg/L. Wastewaters from several industries which process plant matter can contain phytosterols at concentrations in excess of the above-stated level. Despite their endocrine disruption potential, very little is known about phytosterol physical properties and their biotransformation potential in biological treatment systems. Aerated stabilization basins (ASBs) are c

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13

Mullen, Lisa Maria. "Potential interactions between components of the endocrine and immune systems of Locusta migratoria." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406337.

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14

Zhao, Zunyang. "Removal of Estrogens at Full and Pilot Scale Livestock Manure Treatment Systems." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/26067.

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Three experiments were conducted to 1) develop appropriate methods for livestock manure estrogen analysis; 2) determine estrogen removal in different manure treatment systems; and 3) determine estrogen removal from dairy manure in pilot scale reactors. In Experiment I, the recoveries of 17Ã -estradiol (E2) and estriol (E3) were evaluated in double distilled water and dairy manure after a base extraction and analysis of estrogens by enzyme-linked immunoassay (ELISA) and yeast estrogen screen (YES) assay. The recoveries of E2 were 104% (ELISA) and 97% (YES) in double distilled water. 112% of E2

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15

Silva, Ana Lucia. "Interferentes endócrinos no meio ambiente: um estudo de caso em amostras de água in natura e efluente de estação de tratamento de esgotos da região metropolitana de São Paulo." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/6/6134/tde-21072009-091520/.

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Interferentes endócrinos são substâncias que podem causar efeitos deletérios na saúde, crescimento e capacidade reprodutiva dos organismos, e colocam em risco a continuidade de várias espécies. Suas fontes são as mais variadas possíveis, sendo possível detectá-los em alguns alimentos, produtos farmacêuticos, produtos químicos e seus respectivos subprodutos de degradação. Também vêm sendo detectados em várias matrizes ambientais, tais como o ar, solo, água e sedimentos. Devido as suas capacidades de ação sinérgica, aditiva e antagônica é extremamente complexa a determinação da relação dose-resp

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16

Davis, Tracy Leigh. "Role of the endocrine and immune systems in the developing and regressing corpus luteum." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085166703.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 202 p.; also includes graphics (some col.). Includes bibliographical references (p. 151-185). Available online via OhioLINK's ETD Center

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17

Köksal, Ersöz Elif. "A mathematical study on coupled multiple timescale systems, synchronization of populations of endocrine neurons." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066516/document.

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Dans cette thèse, nous étudions les propriétés de synchronisation d'oscillateurs lents-rapides inspirés de la neuroendocrinologie et des neurosciences, en se concentrant sur les effets des phénomènes de type canard et bifurcations dynamiques sur le comportement collectif.Nous partons d'un système de dimension 4 qui représente les caractéristiques dynamiques qualitatives et quantitatives du profil de sécrétion de la neurohormone GnRH (gonadotropin releasing hormone) au cours d'un cycle ovarien. Ce modèle est constitué de deux oscillateurs de FitzHugh-Nagumo avec pour chacun des échelles de temp

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18

Ruhlen, Rachel L. "Diets, estrogen environment of the fetus, and development of the reproductive tract and other systems /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091965.

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19

Hidayat, Egi. "On Identification of Biological Systems." Doctoral thesis, Uppsala universitet, Avdelningen för systemteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215699.

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System identification finds nowadays application in various areas of biological research as a tool of empiric mathematical modeling and model individualization. A fundamental challenge of system identification in biology awaits in the form of response variability. Furthermore, biological systems tend to exhibit high degree of nonlinearity as well as significant time delays. This thesis covers system identification approaches developed for the applications within two particular biomedical fields: neuroscience and endocrinology. The first topic of the thesis is parameter estimation of the classi

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20

Monges-Ranchin, Geneviève. "Les cellules endocrines de l'estomac et leur pathologie." Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX21917.

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21

WILLIAMS, CYNTHIA LYNN. "THE EFFECTS OF STRESS ON GASTROINTESTINAL FUNCTION: INTERACTIONS OF NEURAL AND ENDOCRINE SYSTEMS IN MEDIATING STRESS-INDUCED INTESTINAL DYSFUNCTION IN RATS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184193.

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Stress-related functional bowel disease is a common, often incapacitating, problem in humans; the symptomatology of stress-related intestinal dysfunction is: (1) impaired small intestinal transit and motility, and (2) increased large intestinal transit and, commonly, diarrhea. The etiology of stress-induced intestinal dysfunction is completely unresolved, and the lack of an appropriate animal model has hindered studies of causality. We compared a number of stressors and their resultant effects on intestinal transit, a measure of the propulsive motor activity of the gut, in the rat. We found th

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22

Olujimi, Olanrewaju Olusoji. "The concentrations, distribution and health risk assessment of suspected endocrine disrupting chemicals (phenols, phthalates and heavy metals) in freshwater systems of Cape Town, South Africa." Thesis, Cape Peninsula University of Technology, 2012. http://hdl.handle.net/20.500.11838/2009.

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Thesis (DTech (Environmental Health))--Cape Peninsula University of Technology, 2012.<br>Environmental pollution with persistent organic chemicals and inorganic trace metals is an increasingly important issue. Recently, a variety of chemicals are introduced in a very large scale on the surface water network. The main pathway of these pollutants into the environment was identified as wastewater treatment plants (WWTPs). The extended use of chemicals in many product formulations and insufficient WWTPs has lead to an increase in the levels of the detected micro-pollutants wastewater effluent

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23

Tassou, Koffi Tcha [Verfasser]. "Assessment of potential endocrine disrupting agrochemicals in freshwater systems: full life-cycle testing over two generations with the aquatic midge Chironomus riparius (Meigen) / Koffi Tcha Tassou." Landau : Universitätsbibliothek Landau, 2013. http://d-nb.info/1032060654/34.

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24

Wang, Siqi. "NONINVASIVE ASSESSMENT AND MODELING OF DIABETIC CARDIOVASCULAR AUTONOMIC NEUROPATHY." UKnowledge, 2012. http://uknowledge.uky.edu/cbme_etds/5.

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Noninvasive assessment of diabetic cardiovascular autonomic neuropathy (AN): Cardiac and vascular dysfunctions resulting from AN are complications of diabetes, often undiagnosed. Our objectives were to: 1) determine sympathetic and parasympathetic components of compromised blood pressure regulation in patients with polyneuropathy, and 2) rank noninvasive indexes for their sensitivity in diagnosing AN. Continuous 12-lead electrocardiography (ECG), blood pressure (BP), respiration, regional blood flow and bio-impedance were recorded from 12 able-bodied subjects (AB), 7 diabetics without (D0), 7

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25

Kromrey, Natalie A., and University of Lethbridge Faculty of Arts and Science. "The effects of wastewater treatment plant effluent and agricultural runoff on the reproductive systems of fathead minnow, Pimephales promelas." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2009, 2009. http://hdl.handle.net/10133/2519.

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Endocrine disrupting compounds and pesticides have been detected in rivers and irrigation canals of Southern Alberta, a semiarid region with irrigation-dependent crop production, intensive livestock operations, and a growing human population. However, little is known about the effects of agricultural runoff or wastewater treatment plant (WWTP) effluent in Southern Alberta on fish. Reproductive effects of WWTP effluents from the cities of Lethbridge and Medicine Hat, as well as agricultural runoff in the Lethbridge Northern Irrigation District canals, were investigated in a field study with wil

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26

Archer, Edward. "Androgen controlled secondary sexual characters in the male African clawed frog, Xenopus laevis, as potential biomarkers for endocrine disruptor contaminants (with special reference to fungicides) in aquatic systems." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86508.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Endocrine disrupting contaminants (EDCs) coming from households, industrial parks, wastewater (sewage) treatment and agricultural areas have been shown to pollute our freshwater systems. These contaminants may disrupt early development and reproductive systems in freshwater organisms (fish, frogs and crocodile species) as well as humans. Agricultural pesticides are shown as a large contributor to endocrine disruption activity in water catchment areas through spray drift, runoff, and/or groundwater leeching. Although South Africa

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27

HUANG, HE. "REDUCTION OF PERCHLORATE BY ZERO VALENT IRON." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1131047520.

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28

Lambert, Julie. "Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/344.

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NOD mice model human type 1 diabetes and have been used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. Costimulation blockade-based tolerance protocols that induce prolonged skin and permanent islet allograft survival in non-autoimmune mice have failed in NOD mice. To investigate the underlying mechanisms, we generated NOD hematopoietic chimeras. We were able to show that dendritic cell maturation defects seen in NOD mice are partially corrected in mixed hematopoietic chimeras. Furthermore, skin allograft survival was dependent upon the phe

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29

Todd, Derrick James. "Role of the Intestinal Immune System in the Pathogenesis of Autoimmune Diabetes in the BB Rat Model of Type 1 Diabetes Mellitus." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/138.

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The intestine is the largest lymphoid organ in the body, challenged constantly by an enonnous quantity and diversity of antigens. Distinct from peripheral lymphocytes, intestinal lymphocytes have evolved unique mechanisms of tolerance and appear to govern mucosal processes such as "chronic physiologic inflammation" and oral tolerance. Failure of mucosal tolerance has been implicated in the pathogenesis of several diseases, including inflammatory bowel disease, celiac disease, and even autoimmune diabetes. One population of intestinal lymphocytes, intraepithelial lymphocytes (IELs), exists with

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30

Gross, Josef Johann [Verfasser], Frieder Jörg Akademischer Betreuer] Schwarz, Rupert M. [Akademischer Betreuer] Bruckmaier, and Heinrich H. D. [Akademischer Betreuer] [Meyer. "Differential adaptation of performance, metabolism and endocrine systems to lactational and nutrition induced negative energy balance of dairy cows / Josef Johann Gross. Gutachter: Rupert M. Bruckmaier ; Heinrich H. D. Meyer. Betreuer: Frieder Jörg Schwarz." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/101958890X/34.

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31

Amante, Daniel J. "Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/848.

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Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters. Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients wi

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Amante, Daniel J. "Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/848.

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Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters. Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients wi

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33

Crane, James William. "Limbic system control of endocrine stress responses /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16769.pdf.

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Morrison, Alan R. "Poly(ADP)-Ribose Polymerase Activity in the Eukaryotic Mono-ADP-Ribosyl Transferase, ART2: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/126.

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The glycophosphatidylinositol(GPI)-linked membrane protein ART2 is an antigenic determinant for T lymphocytes that regulate the expression of diabetes in the BB/W rat model. Though little is understood of the physiologic role of ART2 on T lymphocytes, ART2 is a member of the mono-ADP-ribosyl transferase subgroup ofthe ADP-ribosyl transferase (ART) protein family. The ART protein family, which traditionally has been divided into mono-ADP-ribosyl transferases (mono-ARTs), poly(ADP)-ribose polymerases (PARPs), and ADP-ribosyl cyclases, influences various aspects of cellular physiology including:

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Jones, Maren Bell. "Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5006.

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Thesis (M.A.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 29, 2007) Vita. Includes bibliographical references.

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Batisweiler, Georgia. "Kognitive Leistungen bei Patienten mit angeborenen und erworbenen Hormonstörungen." München : Universität der Bundeswehr München, 1995. http://catalog.hathitrust.org/api/volumes/oclc/68945083.html.

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Alshammari, Muna A. B. J. M. "The role of nurses in diabetes care and the impact of the different approaches of nurses' role on patients percieved quality of nursing care : two case studies from the UK and Kuwait." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49796/.

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Type 2 diabetes (T2D) is considered as a global major health problem, which requires healthcare systems to find solutions to meet the needs of the great numbers of people with T2D. One key to these solutions is nurses who undertake the provision of diabetes care. Nursing care in T2D varies across countries as a result of differences in healthcare systems, the way in which they are organised and other factors relating to nursing practice. The UK and Kuwait are two countries which have high incidences of T2D but differing health care delivery models, which has raised the need to understand the d

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Anyanwagu, Uchenna Chidi. "Cardiovascular and metabolic outcomes associated with insulin use in type 2 diabetes : evidence from insulin users in the UK primary care." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47654/.

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In clinical use, insulin improves glycaemic control at the cost, typically, of weight gain and more hypoglycaemia – both being risk factors for cardiovascular (CV) disease mortality. The issue of the effect of exogenous insulin on CV disease meanwhile has been debated for a long time. Data on the CV outcomes associated with insulin-treated diabetes in both randomised trials and observational studies have largely been inconsistent. Thus, a balance of the positives and the negatives of insulin therapy needs to be taken into account when prescribing insulin in routine clinical practice, particula

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Tewari, Nilanjana. "Mechanisms underlying obesity-related insulin resistance." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/34081/.

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This thesis investigates the effect of body composition on insulin resistance and the impact of supplementation with nutritional support or carbohydrate treatment. Insulin resistance occurs as a response to a number of stressors, including surgery. However, the mechanism underlying the development of insulin resistance is as yet unclear. Adipose tissue distribution appears to play a role in the development of insulin resistance and obesity-related complications. In obese and non-obese patients undergoing open abdominal surgery who received preoperative carbohydrate or placebo, there was a sign

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Sciota, Flavia. "Effect of hyperglycaemia on VEGF-A splice variants, junctional integrity and vascular leakage in human feto-placental vessels from normal and type 1 diabetic pregnancies." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/27978/.

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Hyperglycaemia is a main feature of diabetes, and this pathology is a main complication of pregnancy. Diabetic patients often require tighter glycaemic control in pregnancy, as glucose metabolism changes, and insulin dosages need to be adjusted. Throughout gestation, the placenta is therefore subjected to periods of hyperglycaemic insult. Thus, we wished to study how brief periods of hyperglycaemia affected the feto-placental vasculature, through study of important permeability molecules, pro-permeability VEGFa, anti-permeability VEGFb, and junctional stability molecule VE-cadherin. A 15mM con

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Wu, Hsiu-Li. "An investigation of type 2 diabetes self-management in Taiwan." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10756/.

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In Taiwan, as in other countries, type 2 diabetes is a major public health problem. Taiwanese nurses are being called upon to play an increasingly large role in diabetes care, but little is known about the factors that contribute to good or poor diabetes self-management in the Taiwanese context. This study is an exploratory investigation of Taiwanese women’s experiences of living with type 2 diabetes. Adopting an open-ended qualitative approach, the research aimed to discern personal characteristics, strategies, socio-cultural and health system factors that affected women’s ability to manage t

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McCann, John Patrick. "Pulmonary neuroendocrinology in health and disease : an immunocytochemical and radioimmunoassay study." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259343.

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Fernández, Méndez Rocío. "GlyCon : glycaemic control of stress hyperglycaemia in intensive care units." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42920/.

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Background and aims Untreated stress-induced hyperglycaemia in critically ill patients has been associated with harmful effects, which can even be fatal. Current evidence about the optimal glycaemic targets, and the most effective and safest methods of glycaemic control (GC) in intensive care units (ICU), is contradictory. GlyCon study aimed to investigate the effectiveness, efficiency and safety of the monitoring and insulin treatment methods for GC implemented in the seven ICUs of an NHS ICU network in the UK. In addition, GlyCon study also aimed to explore the contents of the local protocol

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Aljebab, Fahad. "Corticosteroid toxicity in children." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43388/.

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Corticosteroid medicines have anti-inflammatory and immunosuppressant effects. Corticosteroids are prescribed for a wide range of conditions in children. The duration of treatment ranges from a few days (short course) to long term. They are usually given orally in the different dosage form of tablets, syrup or soluble tablets. There are a wide range of adverse drug reactions (ADRs) associated with corticosteroids. This thesis initially evaluates the incidence of each individual ADR in children using systematic reviews. Prospective studies of palatability and pharmacoepidemiology using differen

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Saker, Saker. "Diabetic retinopathy : in vitro and clinical studies of mechanisms and pharmacological treatments." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37201/.

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Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population in developed countries and thus is one of the major ocular health problems worldwide. Diabetes seems to have paradoxical effects on the microvasculature in different tissues. The concentration of glucose in the cellular microenvironment determines the cells ability to proliferate, as well as its permeability, and react to different cytokines. The main cause of visual loss in diabetic eye disease is caused by an increase in microvascular endothelial permeability which leads to vessel leakage and fl

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Quirk, Helen. "Physical activity among children with type 1 diabetes : an exploration of children's experiences and development of an intervention to promote self-efficacy and participation." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33072/.

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Regular physical activity among children with Type 1 Diabetes Mellitus (T1DM) can help optimise long-term health outcomes. This thesis explores the experience of physical activity among children aged 9-11 years with T1DM and their parents, develops a physical activity intervention and evaluates its feasibility. Social cognitive theories have been drawn upon to develop our understanding and inform theoretically-driven behaviour change strategies. First, a systematic review with meta-analysis evaluates existing physical activity interventions for children with T1DM. The findings confirm the heal

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Aris, Aishairma. "Predicting self-care practices and glycaemic control using health belief model (HBM) in patients with insulin-treated diabetes in Malaysia." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33288/.

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Background: The practice of diabetes self-care plays an important role in glycaemic control. However, not all patients with insulin-treated diabetes engage in their self-care activities. Although there is evidence that self-care practices in patients with insulin-treated diabetes can be understood and predicted by health beliefs proposed by Health Belief Model (HBM), little is known about adult patients due to several methodological weaknesses of previous studies. Furthermore, knowledge is lacking about adults with insulin-treated diabetes in Malaysia. Aim: To examine whether health beliefs su

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Mamza, Jil Billy. "Comparative effectiveness and safety of DPP-4 inhibitors." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33202/.

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Approximately 3 million people throughout the UK suffer with Type 2 diabetes mellitus (T2DM), and are 32% more likely to die early. There remains a lack of evidence for the long-term effectiveness and safety of anti-diabetic drugs in preventing diabetes-related complications, making it unclear how to optimally manage diabetes. Work to date includes observational studies subject to bias, and randomised controlled trials (RCTs), which may not reflect the ‘real world’ situation. The aim of this thesis is to combine such findings via systematic reviews, meta-analyses and retrospective cohort studi

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Kosicka, Anna. "Role of adipose tissue as an endocrine organ in systemic inflammation." Thesis, University of Westminster, 2014. https://westminsterresearch.westminster.ac.uk/item/964qw/role-of-adipose-tissue-as-an-endocrineorgan-in-systemic-inflammation.

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Introduction: The escalating public health problem represented by obesity has spurred multidisciplinary research into adipose tissue and importantly, the molecular biology of the adipocyte. The concept of adipose tissue as an endocrine organ, in addition to an energy storage compartment, is now pivotal in linking excess adiposity to disease states. Recent studies suggest that obesity related metabolic disorders are characterised by mild chronic inflammation as a result of adipocytokine production from fat tissue leading to dysregulation in the pro/anti-inflammatory systemic balance. Adipokines

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Decker, Kimberly Jean. "Gata6 regulates pancreatic branching morphogenesis and endocrine differentiation /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 160-175). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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