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Journal articles on the topic 'Endogen risk'

Author: Grafiati

Published: 29 June 2021

Last updated: 29 July 2025

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1

Santillan Pashma, Antonio Ruben. "Analysis of transmission of conditional volatility from market risk factors." ConcienciaDigital 4, no. 2 (2021): 345–59. http://dx.doi.org/10.33262/concienciadigital.v4i2.1700.

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This article aims to understand the transmission of volatility from the main market indicators of the European financial system, towards market interest rates, focusing on the prices of the swap with maturity of one year and payments of three months as endogen variable and the three main indexes of the European market as CAD, DAX3, and IBEX35, as an exogenous variable. The exogenous will absorb all the necessary information from the market agents as companies, banks, investments funds, or from externals disturbances as European Central Banks and will affect the levels and the slope of the swap

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Bangun, Cicilia Sriliasta, and Tessa Handra. "How Theory of Planned Behavior And Percieved Risk Affect Online Shopping Behavior." Aptisi Transactions on Management (ATM) 5, no. 2 (2021): 169–79. http://dx.doi.org/10.33050/atm.v5i2.1594.

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This study aims to analyze the affect of attitude, subjective norm, perceived behavioral control, and perceived risk on intention to shop online and its impact on online shopping behavior. The exogen variables on this study are attitude, subjective norm, perceived behavioral control, and perceived risk. While the endogen variables are intention to shop online and behavior to shop online. Data collection was carried out by distributing 100 questionnaires to users of e-commerce as respondents. By using SEM PLS, this result of this study showed that from 5 initial hypotheses were developed; only

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Becerra-Loaiza, Denisse Stephania, Luisa Fernanda Roldan Flores, Luis Antonio Ochoa-Ramírez, et al. "HLA-G 14 bp Ins/Del (rs66554220) Variant Is Not Associated with Breast Cancer in Women from Western Mexico." Current Issues in Molecular Biology 45, no. 8 (2023): 6842–50. http://dx.doi.org/10.3390/cimb45080432.

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HLA-G is a physiology and pathologic immunomodulator detrimentally related to cancer. Its gene is heavily transcriptionally and post-transcriptionally regulated by variants located in regulator regions like 3′UTR, being the most studied Ins/Del of 14-bp (rs66554220), which is known to influence the effects of endogen cell factors; nevertheless, the reports are discrepant and controversial. Herein, the relationship of the 14-bp Ins/Del variant (rs66554220) with breast cancer (BC) and its clinical characteristics were analyzed in 182 women with non-familial BC and 221 disease-free women as a ref

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Hartoyo, Arif Tantri, and Nuring Pangastuti. "Fibroid Uterus dan Infertilitas." Cermin Dunia Kedokteran 49, no. 3 (2022): 143–46. http://dx.doi.org/10.55175/cdk.v49i3.208.

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Fibroid uterus (mioma atau leiomioma) adalah tumor monoklonal jinak sel otot polos rahim manusia. Fibroid merupakan tumor uterus yang paling umum dijumpai pada kelompok usia reproduksi. Keberadaannya dapat tanpa gejala, bergejala ringan hingga berat. Faktor risiko fibroid termasuk usia, ras, faktor hormon endogen ataupun eksogen, obesitas, infeksi rahim, serta gaya hidup (diet, konsumsi kafein dan alkohol, aktivitas fisik, stres, merokok). Klasifikasi fibroid mengikuti panduan FIGO untuk leiomioma. Diagnosis berdasarkan tanda dan gejala, pemeriksaan fisik dan penunjang. Fibroid dapat merupakan

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Lawrencesou, David, Chanela Febe, Masdalena Masdalena, and Chairul Radjab Nasution. "RISK FACTORS FOR CONTACT DERMATITIS IN WORKERS AT TOFU FACTORY." Jambura Journal of Health Sciences and Research 4, no. 1 (2022): 484–92. http://dx.doi.org/10.35971/jjhsr.v4i1.12219.

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Abstrak Latar Belakang: Dermatitis kontak adalah penyakit kulit yang disebabkan oleh suatu peradangan akibat paparan dari substansi asing. Berdasarkan jenisnya, dermatitis kontaki dibagi menjadi duat yaitu, dermatitis kontak alergi dan dermatitisi kontak iritan, dapat bersifat akut danlkronis. Terdapat berbagai faktor yang dapat menyebabkan Dermatitis kontak akibat kerja yaitu faktor eksogen dan faktor endogen. Tujuan: Untuk mengetahui faktor-faktor resiko terjadinya dermatitis kontak pada karyawan di Pabrik Tahu. Metode Penelitian: Penelitian ini menggunakan metode kuantitatif yang bersifat a

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Aryana, I. Gusti Putu Suka, Anak Agung Ayu Ratih Hapsari, and Raden Ayu Tuty Kuswardhani. "Myokine Regulation as Marker of Sarcopenia in Elderly." Molecular and Cellular Biomedical Sciences 2, no. 2 (2018): 38. http://dx.doi.org/10.21705/mcbs.v2i2.32.

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The elderly population will increase as well as increasing life expectancy. Health problems in elderly will be more complex and need a comprehensive management. One of the problems that arise from the aging process is sarcopenia. Sarcopenia is a decreasing in muscle mass and muscle strength or muscle function caused by multifactorial not only due to aging process, but also nutrition, immobilization, genetics and others risk factors. Muscle is an endogen organ that produces various proteins that can affect the health system. This protein is referred to as myokine. Myokine is anti-inflammation c

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Parakhina, Viktoriya, Yelena Mikhailovna Laryushina, and Olga Ponamareva. "Association between Endocan, PAI-1 and intima media thickness in patients with high diabetes risk." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 106, no. 2 (2022): 134–44. http://dx.doi.org/10.31489/2022bmg2/134-144.

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There is no information in the literature on the ratio of the concentrations of Endocan, PAI-1, and intima media thickness (IMT) in patients with high diabetes risk. This study aims to investigate the relationships between endothelial dysfunction biomarkers: Endocan, Plasminogen Activator Inhibitor-1(PAI-1), insulin resistance (IR) indicators, and IMT of the common carotid artery (CCA) in patients with risk of type 2 diabetes mellitus (T2DM). A case-control study was held, including 184 individuals, aged from 18 to 65 years. According to FINDRISC scale, patients were divided into 2 groups: Gro

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Dohude, Gostry Aldica, and Cindy Audria. "<p><strong>Tingkat pengetahuan mahasiswa kedokteran gigi tentang faktor risiko karsinoma sel skuamosa rongga mulut</p><strong><em>Knowledge level of oral squamous cell carcinoma risk factors Among dental students</em><strong>." Jurnal Kedokteran Gigi Universitas Padjadjaran 34, no. 2 (2022): 93. http://dx.doi.org/10.24198/jkg.v34i2.34845.

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ABSTRAKPendahuluan: Karsinoma sel skuamosa rongga mulut (KSS) merupakan salah satu jenis tumor ganas yang berasal dari displasia jaringan lunak epitelium, hal ini ditandai dengan perubahan proliferasi sel skuamosa displastik pada permukaan lapisan epitelium yang ada di rongga mulut. Insidensi kanker mulut yang masih terus meningkat diakibatkan karena adanya perbedaan faktor risiko di berbagai negara terutama Asia. Selain faktor dari dalam (endogen) seperti genetik dan malnutrisi, faktor risiko KSS dapat berasal dari lingkungan (eksogen) yaitu paparan sinar matahari secara kronis, Human papillo

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Ilham Muhammad Ridwan, Deis Hikmawati, and R. Kince Sakinah. "Karakteristik Pasien dan Gambaran Klinis Dermatitis Kontak Iritan." Bandung Conference Series: Medical Science 5, no. 1 (2025): 1003–10. https://doi.org/10.29313/bcsms.v5i1.17266.

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Abstract. Irritant Contact Dermatitis (ICD) is a skin condition that arises due to contact with chemical substances. It is one of the most common skin diseases in society as a result of daily activities, especially in the workplace. Contact dermatitis is categorized into irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD). Irritant Contact Dermatitis is a local inflammatory response that occurs when chemicals or physical factors directly cause cytotoxic damage to the skin. It is influenced by two risk factors: endogenous factors such as age, gender, skin location, history o

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Wu, Tsung-Jui, Chih-Hsien Wang, Yu-Hsien Lai, Chiu-Huang Kuo, Yu-Li Lin, and Bang-Gee Hsu. "Serum Endocan Is a Risk Factor for Aortic Stiffness in Patients Undergoing Maintenance Hemodialysis." Medicina 60, no. 6 (2024): 984. http://dx.doi.org/10.3390/medicina60060984.

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Background and Objectives: Endocan, secreted from the activated endothelium, is a key player in inflammation, endothelial dysfunction, proliferation of vascular smooth muscle cells, and angiogenesis. We aimed to investigate the link between endocan and aortic stiffness in maintenance hemodialysis (HD) patients. Materials and Methods: After recruiting HD patients from a medical center, their baseline characteristics, blood sample, and anthropometry were assessed and recorded. The serum endocan level was determined using an enzyme immunoassay kit, and carotid–femoral pulse wave velocity (cfPWV)

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Aydin, Hasan Riza, Senol Adanur, Fatih Ozkaya, et al. "Diagnostic Value of Serum and Urine Endocan Levels in Nonmuscle Invasive Bladder Cancer: A Prospective Comparative Study." International Journal of Clinical Practice 2024 (April 30, 2024): 1–7. http://dx.doi.org/10.1155/2024/2699706.

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Objective. This prospective study aimed to explore the potential diagnostic value of endocan levels in bladder cancer by investigating a possible association of serum and urine endocan levels with the stage and grade of bladder tumors in patients with nonmuscle-invasive bladder cancer (NMIBC) in terms of risk stratification. Materials and Methods. Participants included 66 male patients with NMIBC. Patients with full pathology results, NMIBC stage T1, and healthy controls were categorized as groups 1, 2, and 3, respectively. Patients were further classified into high- and low-grade groups follo

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Kim, Jin Sug, Gang Jee Ko, Yang Gyun Kim, et al. "Plasma Endocan as a Predictor of Cardiovascular Event in Patients with End-Stage Renal Disease on Hemodialysis." Journal of Clinical Medicine 9, no. 12 (2020): 4086. http://dx.doi.org/10.3390/jcm9124086.

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Endocan, a potential biomarker of endothelial dysfunction, is associated with increased cardiovascular risk. We investigated the utility of plasma endocan for predicting cardiovascular risk in end-stage renal disease (ESRD) patients undergoing hemodialysis. Of the 452 patients in the K-cohort, 354 with available plasma endocan levels were enrolled. The correlation between plasma endocan levels and the clinical characteristics of a study population were analyzed. We divided patients into two groups, according to plasma endocan levels, and investigated the predictive value of endocan for the occ

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Ziaee, Mojtaba, Sina Mashayekhi, Samad Ghaffari, Javad Mahmoudi, Parvin Sarbakhsh, and Alireza Garjani. "Predictive Value of Endocan Based on TIMI Risk Score on Major Adverse Cardiovascular Events After Acute Coronary Syndrome." Angiology 70, no. 10 (2018): 952–59. http://dx.doi.org/10.1177/0003319718815241.

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We assessed the prognostic value of serum levels of endocan in patients with the acute coronary syndrome (ACS) through its correlation with the Thrombolysis in Myocardial Infarction (TIMI) risk score and compared the possible association with clinical outcomes. In this prospective cross-sectional study, we enrolled 320 patients with documented ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) who underwent diagnostic coronary angiography. Endocan was measured soon after admission in the emergency department. In-hospital death, heart failure, and re

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Bălănescu, Anca, Ioana Florentina Codreanu, Valentina Daniela Comanici, Iustina Violeta Stan, Eugenia Bălănescu, and Paul Bălănescu. "Endocan and Lumican in Relation to Cardiometabolic Risk in a Pediatric Overweight and Obese Cohort: A Cross-Sectional Study." BioMed Research International 2020 (August 17, 2020): 1–11. http://dx.doi.org/10.1155/2020/2102401.

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The aim of the study was to evaluate serum Endocan and Lumican levels as biomarkers for pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and to explore their associations with pediatric cardiometabolic risk factors. We conducted a cross-sectional study on 68 pediatric obese and overweight (O&O) patients. Ten healthy controls were recruited. Serum Lumican and Endocan levels were analyzed using ELISA kits. O&O patients had lower levels of Endocan compared to healthy controls (p<0.001). There were no differences between serum Endocan levels in O&O patients with NAFLD and those wi

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Constantin, Laura, Anca Ungurianu, Anca Streinu-Cercel, et al. "Investigation of Serum Endocan Levels in SARS-CoV-2 Patients." International Journal of Molecular Sciences 25, no. 5 (2024): 3042. http://dx.doi.org/10.3390/ijms25053042.

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Endocan is an endothelial-cell-specific proteoglycan (ESM-1) and has emerged as an endothelial dysfunction and inflammatory marker in recent years. Endocan can be used as a marker of inflammatory endothelial dysfunction in endothelium-dependent disease: cardiovascular disease, sepsis, lung and kidney disease and malignancies. Recent data suggest that endothelial dysfunction is a key mechanism in COVID-19 pathogenesis. Endotheliitis and thrombo-inflammation are associated with severe forms of SARS-CoV-2 infection, and endocan is currently under investigation as a potential diagnostic and progno

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Lin, Jia-Hong, Bang-Gee Hsu, Chih-Hsien Wang, and Jen-Pi Tsai. "Endocan as a Potential Marker for Predicting All-Cause Mortality in Hemodialysis Patients." Journal of Clinical Medicine 12, no. 23 (2023): 7427. http://dx.doi.org/10.3390/jcm12237427.

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Endocan, a pro-inflammatory cytokine and pro-angiogenic factor, is a marker of endothelial dysfunction and has been proven to correlate with cardiovascular disease. In hemodialysis (HD) patients, cardiovascular disease is the major cause of mortality. Our study aimed to investigate the relationship between serum endocan and all causes of mortality in HD patients. A total of 103 patients, aged over 20 years old and undergoing HD for more than 3 months, were included and followed for 36 months. Mortality events, serum endocan, biochemical data, body mass index, systolic and diastolic blood press

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Balta, Sevket, and Cengiz Ozturk. "Endocan, Obstructive Sleep Apnea, and Vascular Risk." Angiology 67, no. 4 (2015): 305–6. http://dx.doi.org/10.1177/0003319715591332.

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Souza, Livia Victorino de, Vanessa Oliveira, Aline Oliveira Laurindo, et al. "Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant." International Journal of Nephrology 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2180765.

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Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases. Few published data have described the role of endocan in pediatric renal transplant (RT) patients. We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients’ blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. We determined positive correlations between the e

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Adewuyi, E. O., D. Mehta, Yadav Sapkota, et al. "Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways." Human Reproduction 37, no. 2 (2021): 366–83. http://dx.doi.org/10.1093/humrep/deab254.

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Abstract STUDY QUESTION Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER Our results confirm a significant but non-causal association of endometriosis with asthma implicating shared genetic susceptibility and biological pathways in the mechanisms of the disorders, and potentially, their co-occurrence. WHAT IS KNOWN ALREADY Some observational studies have reported a pattern of co-occurring relationship between endometriosis and asthma; however, there is conflicting evidence and t

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Zonda, Gabriela Ildiko, Radu Zonda, Andrei Tudor Cernomaz, Luminita Paduraru, Andreea Luciana Avasiloaiei, and Bogdan Dragos Grigoriu. "Endocan - a potential diagnostic marker for early onset sepsis in neonates." Journal of Infection in Developing Countries 13, no. 04 (2019): 311–17. http://dx.doi.org/10.3855/jidc.11202.

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Introduction: Neonatal early onset sepsis assessment is based on the history of pregnancy and delivery and nonspecific clinical signs. None of the biomarkers currently in use for clinical practice has adequate prognostic value, so it is not possible to clearly distinguish neonates with culture-proven sepsis from those with only risk factors or clinical suspicion. Endocan is an endothelial mediator involved in the inflammatory response that is present in low concentrations in the serum of healthy subjects, and in much higher concentrations in patients with SIRS and septic shock. The purpose of

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Šafer, Mario, Ivan Feldi, Ines Šahinović, et al. "Serum Endocan as a Predictor of Survival and Cardiovascular Events in Patients Without Diabetic Kidney Disease on Chronic Haemodialysis: A Prospective, Observational Study." Medicina 61, no. 6 (2025): 991. https://doi.org/10.3390/medicina61060991.

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Background and Objectives: Chronic kidney disease (CKD) is an increasingly significant global public health issue, with cardiovascular disease being the leading cause of mortality. Endothelial dysfunction plays a critical role, but diagnostic tools have certain limitations. Endocan, a soluble proteoglycan, emerged as a promising endothelial dysfunction marker and potential major adverse cardiovascular event (MACE) predictor in haemodialysis (HD) patients. Materials and Methods: In this single-centre, observational, prospective study, non-diabetic HD patients without prior MACEs were monitored.

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Abdikalikova, Togzhan, Lyudmila Turgunova, Botagoz Baidildina, and Zhanar Mursalova. "Endocan level in patients with chronic kidney disease." Journal "Medicine" 11-12, no. 221-222 (2021): 35–42. http://dx.doi.org/10.31082/1728-452x-2020-221-222-11-12-35-42.

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The relevance of the work is due to the high prevalence of chronic kidney disease (CKD) among the population and high mortality from cardiovascular disease (CVD) in this population. In this connection, it is necessary to search for new biomarkers in order to early identify individuals with cardiovascular risk in patients with CKD. The purpose of this study to assess the endocan level in patients with CKD depending on the glomerular filtration rate (GFR), to study the relationship between the endocan level and other cardiovascular risk factors in patients with CKD. Material and methods. 153 res

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Boyuk, Banu, Seher Irem Cetin, Hande Erman, Samet Sevinc, Umit Bulut, and Savas Guzel. "Evaluation of serum endocan levels in relation to epicardial fat tissue thickness in metabolic syndrome patients." Archives of Medical Science – Atherosclerotic Diseases 5, no. 1 (2020): 290–96. http://dx.doi.org/10.5114/amsad.2020.103031.

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IntroductionMetabolic syndrome has been recognized as a predictor of cardiovascular diseases. Epicardial fat tissue (EFT) thickness has recently been shown to be a predictor of cardiovascular diseases in metabolic syndrome patients. Endocan is a novel molecule which is considered to be an early marker of endothelial dysfunction. Our aim was to evaluate endocan serum levels for the first time in metabolic syndrome patients, in relation to EFT thickness.Material and methodsThe study included 44 patients with metabolic syndrome who had neither chronic kidney disease nor chronic inflammation and 2

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Ying, Jun, Danfei Zhou, Tongjie Gu, and Jianda Huang. "Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients." Canadian Respiratory Journal 2019 (April 1, 2019): 1–6. http://dx.doi.org/10.1155/2019/2476845.

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Background. Severe pneumonia (SP) has been widely accepted as a major cause for acute respiratory distress syndrome (ARDS), and the development of ARDS is significantly associated with increased mortality. This study aimed to identify potential predictors for ARDS development in patients with SP. Methods. Eligible SP patients at admission from January 2013 to June 2017 were prospectively enrolled, and ARDS development within hospital stay was identified. Risk factors for ARDS development in SP patients were analyzed by univariate and multivariate logistic regression analysis. The receiver oper

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Balta, Sevket, and Dimitri P. Mikhailidis. "Endocan and Erectile Dysfunction." American Journal of Men's Health 13, no. 6 (2019): 155798831989388. http://dx.doi.org/10.1177/1557988319893889.

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Endothelial dysfunction (ED) occurs early in the development of atherosclerosis. Predictors of vascular risk including obesity, hyperlipidemia, metabolic syndrome, diabetes mellitus, and hypertension are associated with both vascular endothelial and ED. Endocan is a novel marker of endothelial dysfunction, inflammation, and atherosclerosis. Raised endocan levels (usually measured by ELISA assays) were reported in some cardiovascular diseases and related conditions. Increased endocan levels may represent the endothelial and inflammatory components of the pathogenesis of ED and may, therefore, p

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Reikvam, Håkon, Kimberley Joanne Hatfield, Øystein Wendelbo, Roald Lindås, Philippe Lassalle, and Øystein Bruserud. "Endocan in Acute Leukemia: Current Knowledge and Future Perspectives." Biomolecules 12, no. 4 (2022): 492. http://dx.doi.org/10.3390/biom12040492.

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Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor levels) has an adverse prognostic impact in several malignancies. The p14 endocan degradation product can also be detected in serum/plasma, but previous clinical studies as well as previously unpublished results presented in this review suggest that endocan and p14 endocan fragment levels reflect different biological characteristics, and the endoca

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Ozden, Hatice Kaya, Mualla Polat, Serkan Ozturk, and Güler Bugdayci. "Assessment of subclinical cardiac damage in chronic plaque psoriasis patients: a case control study." Archives of Medical Science – Atherosclerotic Diseases 1, no. 1 (2016): 126–32. http://dx.doi.org/10.5114/amsad.2016.64165.

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<b>Introduction: </b> Epidemiological studies have suggested that patients with psoriasis are at an increased risk of developing cardiovascular diseases. Chronic inflammation may play a role in the pathogenesis of atherosclerosis in psoriasis patients. Recent studies have evaluated the expression of plasma endocan and homocysteine levels. Endocan is a marker of vascular endothelial damage, and homocysteine plays a role in the development of atherosclerosis. Plasma endocan and homocysteine levels, as well as echocardiographic parameters, were evaluated in patients with psoriasis to

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Klisic, Aleksandra, and Dimitrios Patoulias. "The Role of Endocan in Cardiometabolic Disorders." Metabolites 13, no. 5 (2023): 640. http://dx.doi.org/10.3390/metabo13050640.

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Discovered two decades ago, endocan still represents an intriguing biomarker related to inflammation. Endocan is a soluble dermatan sulphate proteoglycan secreted by endothelial cells. Its expression is observed in tissues related to the enhanced proliferation, especially hepatocytes, lungs, kidneys, etc. Endocan has been investigated in many cardiometabolic disorders that are tightly connected with inflammation, such as type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, non-alcoholic fatty liv

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Aciksari, Gonul, Murat Kavas, Adem Atici, et al. "Endocan Levels and Endothelial Dysfunction in Patients With Sarcoidosis." Angiology 69, no. 10 (2018): 878–83. http://dx.doi.org/10.1177/0003319718775283.

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A systemic inflammatory reaction is a common feature of both sarcoidosis and atherosclerosis. Endothelial-cell specific molecule 1 (endocan) is a marker of vascular pathology which also shows a correlation with inflammation, endothelial dysfunction, and atherosclerosis. The objective of this study was to evaluate the vascular involvement in sarcoidosis using serum endocan levels and brachial artery flow–mediated dilation (FMD), a marker of endothelial dysfunction. We included 53 patients with sarcoidosis without conventional cardiovascular risk factors and 40 healthy controls. Endothelial func

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Sherief, Laila M., Elhamy R. Abd El-khalek, Ibrahim A. Libda, et al. "Serum endocan and endothelial dysfunction in childhood acute lymphoblastic leukemia survivors: a tertiary center experience." Therapeutic Advances in Chronic Disease 12 (January 2021): 204062232110159. http://dx.doi.org/10.1177/20406223211015963.

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Background: An increased risk of cardiovascular complications is reported in survivors of childhood acute lymphoblastic leukemia (ALL). Early identification of impaired vascular health may allow for early interventions to improve outcomes. Aim: The study was conducted to assess the endothelial dysfunction in ALL survivors using a new marker, serum endocan, and measurement of the mean common carotid arteries intima media thickness (cIMT). Methods: A case-control study was conducted on 100 childhood ALL survivors (aged 6–18 years), with 80 healthy age and sex-matched children as a control group.

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Sági, Balázs, Tibor Vas, Csenge Gál, et al. "The Relationship between Vascular Biomarkers (Serum Endocan and Endothelin-1), NT-proBNP, and Renal Function in Chronic Kidney Disease, IgA Nephropathy: A Cross-Sectional Study." International Journal of Molecular Sciences 25, no. 19 (2024): 10552. http://dx.doi.org/10.3390/ijms251910552.

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IgA nephropathy (IgAN) is the most common primary glomerular disease. Endothelin-1 (ET-1) is one of the strongest vasoconstrictor materials in the blood. The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is associated with renal function and poor outcomes in chronic kidney disease (CKD). Serum endocan is a biomarker associated with proinflammatory cytokines, and the increase in the serum level plays a critical role in inflammatory, proliferative, and neovascularization processes and is associated with poor cardiovascular outcomes in patients with CKD too. Identifying high-risk

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Kosir, Gorazd, Borut Jug, Marko Novakovic, Mojca Bozic Mijovski, and Jus Ksela. "Endocan Is an Independent Predictor of Heart Failure-Related Mortality and Hospitalizations in Patients with Chronic Stable Heart Failure." Disease Markers 2019 (April 4, 2019): 1–7. http://dx.doi.org/10.1155/2019/9134096.

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Background. Heart failure (HF) is characterized by unfavorable prognosis. Disease trajectory of HF, however, may vary, and risk assessment of patients remains elusive. In our study, we sought to determine the prognostic impact of endocan—a novel biomarker of endothelial dysfunction and low-grade inflammation—in patients with heart failure. Methods. In outpatients with chronic HF, baseline values of endocan were determined and clinical follow-up for a minimum of 18 months obtained. A multivariate Cox proportional hazard model was built for HF-related death or hospitalization requiring inotropic

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Kok, Mehmet, Suleyman Dolu, Mehmet Emin Arayici, Gokhan Koker, Kadir Balaban, and Ayhan Hilmi Cekin. "The Role of Endocan Expression in the Diagnosis and Grading of Precancerous Gastric Lesions." Diagnostics 15, no. 11 (2025): 1379. https://doi.org/10.3390/diagnostics15111379.

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Background/Aims: Gastric dysplasia is a critical precursor to gastric cancer (GC), and accurate diagnosis and grading of these lesions are essential for effective surveillance and intervention. However, current diagnostic methods such as forceps biopsy have notable limitations, underscoring the need for reliable biomarkers. This study aimed to evaluate the diagnostic and grading utility of endocan, a soluble proteoglycan secreted by activated endothelial cells, in gastric dysplastic lesions. Methods: A total of 72 patients with gastric dysplasia, 80 with gastric adenocarcinoma, and 55 healthy

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Mantilidewi, Kemala Isnainiasih, Nur’adilah Firdaus, Andi Kurniadi, et al. "Wound Dehiscence Following Obstetrics and Gynecology Surgeries: An Observational Study at a Tertiary Hospital in Bandung." Indonesian Journal of Obstetrics & Gynecology Science 7, no. 3 (2024): 314. http://dx.doi.org/10.24198/obgynia.v7i3.658.

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Introduction: Wound dehiscence is a severe postoperative complication that disrupts an abdominal wound closure which can be caused by endogenous or exogenous flora that infect a surgical wound. Many factors are responsible for surgical site infection in obstetric and gynecology patients considering all the basic standards are ideally maintained in tertiary care hospitals. To identify the characteristics of surgical wound dehiscence (SWD) patients who underwent obstetric and gynecological surgeries at Dr. Hasan Sadikin Hospital from 2021 to 2022.Methods: This study utilized a quantitative descr

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He, Jie, PeiPei Li, Weinan Lu, YuanYuan Huang, and Yan Wang. "Association between elevated endocan levels and obstructive sleep apnea hypopnea syndrome in Turkey and China: A meta-analysis." Medicine 102, no. 47 (2023): e36241. http://dx.doi.org/10.1097/md.0000000000036241.

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Background: Endothelial dysfunction has been implicated in the pathogenesis of obstructive sleep apnea–hypopnea syndrome (OSAHS). Previous research has linked endothelial dysfunction to the vascular pathology marker endothelial cell-specific molecule-1 (endocan). This meta-analysis compared endocan concentrations among adult patients with OSAS and controls, and ascertained whether any differences exist. This study aimed to highlight the association between high endocan levels and OSAHS. Methods: A comprehensive, systematic literature search of the PubMed, Cochrane Library, China National Knowl

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Taş, Özlem, and Nuran Gençtürk. "Pelvik inflamatuar hastalık risk faktörleri ve korunma yöntemleri." Sağlık ve Yaşam Bilimleri Dergisi 6, no. 1 (2024): 56–62. http://dx.doi.org/10.33308/2687248x.202461333.

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Pelvik inflamatuar hastalık, endojen servikovajinal mikroorganizmaların serviksten uterusa doğru ilerlemesi sonucu enfeksiyonun, üst genital sisteme yayılması ile ortaya çıkmaktadır. Pelvik inflamatuar hastalık vakalarının çoğunluğu cinsel yolla bulaşan bir enfeksiyonla ilişkilidir. Chlamydia Trachomatis ve Neisseria Gonorrhoeae cinsel yolla bulaşan enfeksiyonlar içerisinde pelvik inflamatuar hastalığa neden olan en yaygın patojenlerdir. Pelvik inflamatuar hastalık bakteriyel vajinoz gibi cinsel yolla bulaşmayan enfeksiyonlardan da kaynaklanabilir. En sık 15 ila 25 yaş arası kadınlarda görülme

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Cheng, Kai-Jen, Hsiao-Teng Chang, Yahn-Bor Chern, Chun-Feng Wu, Jen-Pi Tsai, and Bang-Gee Hsu. "Serum Endocan Levels as a Risk Factor for Peripheral Artery Disease in Non-Dialysis Patients with Chronic Kidney Disease Stages 3–5." Medicina 61, no. 4 (2025): 577. https://doi.org/10.3390/medicina61040577.

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Background and Objectives: Peripheral arterial disease (PAD) is a severe manifestation of atherosclerosis that disproportionately affects patients with chronic kidney disease (CKD) stages 3–5, resulting in a higher prevalence in this group. Currently, it is challenging to detect early PAD in this patient population. This study investigated the association between serum endocan levels and PAD based on the ankle–brachial index (ABI) in non-dialysis patients with CKD stages 3–5. Materials and Methods: Specimens of blood and baseline demographic characteristics were gathered from a total of 164 pa

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Nalbantoğlu, Ayşin, Özgür Kızılca, Savaş Güzel, Hamdi Cihan Emeksiz, and Burçin Nalbantoğlu. "Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children." Angiology 72, no. 7 (2021): 633–39. http://dx.doi.org/10.1177/0003319721995664.

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Obesity in children appears to be associated with increased risk of cardiovascular and metabolic diseases later in life. Early development of insulin resistance (IR) may lead to endothelial dysfunction and increased carotid intima–media thickness (cIMT) even in childhood. We compared endothelial cell-specific molecule-1 (endocan) levels in pediatric obese patients with those in healthy controls to determine whether endocan could be used as a biological marker of complications caused by endothelial damage. In 80 obese pubertal children (44 males [M] and 36 females [F], mean age: 12.8 ± 2.5 year

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Ábel, István, and Katalin Mérő. "A bankszabályozás lehetőségei és korlátai az endogén pénzelmélet keretében." Közgazdasági Szemle 71, no. 6 (2024): 604–23. http://dx.doi.org/10.18414/ksz.2024.6.604.

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The article questions whether the current system of bank regulation can guarantee that banks are subject to a hard budget constraint. We use the framework of post-Keynesian endogenous money theory. Banks deposit loans in companies’ bank accounts, and no external source is needed for the transaction, so banks can in principle create an unlimited amount of money if there is a demand for credit. However, banks’ ability to create money is limited by a number of factors. Using János Kornai’s concept of a soft budget constraint we analyze the factors that cause inherently soft budget constraints fo

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Erman, Hande, Engin Beydogan, Seher Irem Cetin, and Banu Boyuk. "Endocan: A Biomarker for Hepatosteatosis in Patients with Metabolic Syndrome." Mediators of Inflammation 2020 (April 1, 2020): 1–7. http://dx.doi.org/10.1155/2020/3534042.

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Background. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, which has recently been mentioned as an independent cardiovascular risk factor. Objectives. Endocan is a novel molecule of endothelial dysfunction. We aimed to evaluate the associations of serum endocan levels with the hepatic steatosis index (HSI), fatty liver index (FLI), and degrees of hepatosteatosis in patients with metabolic syndrome with NAFLD. Design and Setting. This cross-sectional prospective study was performed in the outpatient clinic of an internal medicine department. Methods.

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Erdal, Yuksel, Nurettin Yavuz, Osman Oguz, Abdullah Soydan Mahmutoglu, and Ufuk Emre. "Endocan: A Novel Predictor of Endothelial Dysfunction in Silent Brain Infarction." Angiology 72, no. 9 (2021): 850–54. http://dx.doi.org/10.1177/00033197211012135.

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Silent brain infarction (SBI) has been considered as a subclinical risk factor for symptomatic possible future stroke. We investigated the association between serum inflammatory markers and SBI. Patients (n = 54) diagnosed with SBI as the study group and 52 individuals as the control group were included in this study. Silent brain infarction is defined as a hyperintense lesion that was ≥3 mm in 1 dimension on fluid-attenuated inversion recovery T2-weighted magnetic resonance image, if the patient had normal neurological examination or had an abnormality that was not consistent with the brain l

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Naomilaksita and Pimpin Utama Pohan. "Profile of Breast Cancer Patients on Estrogen Receptor Expression in RSUD. Dr. Pirngadi Medan 2018-2019." SCRIPTA SCORE Scientific Medical Journal 4, no. 2 (2023): 35–44. http://dx.doi.org/10.32734/scripta.v4i2.10520.

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Background: Breast cancer is a type of cancer with the highest incidence and become the leading cause of death in the world. The incidence rate continues to increase due to various risk factors such as endogenous and exogenous. Immunohistochemical examinations is useful to determine therapy and patient's prognosis. Objectives: This study aims to determine how the profile of breast cancer patients on the expression of estrogen receptor in RSUD. Dr. Pirngadi Medan 2018-2019. Methods: This is descriptive cross-sectional research using random-sampling technique. Data were obtained secondary from m

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Wejnaruemarn, Salisa, Sirinporn Suksawatamnuay, Jakapat Vanichanan, Piyawat Komolmit, Sombat Treeprasertsuk, and Kessarin Thanapirom. "Association between serum endocan levels and organ failure in hospitalized patients with cirrhosis." PLOS ONE 19, no. 12 (2024): e0315619. https://doi.org/10.1371/journal.pone.0315619.

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Background & aims Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endothelial dysfunction plays a key role in the development of organ failure. Serum endocan is a potential new biomarker for endothelial dysfunction. Therefore, this study aimed to assess the association between endocan and organ failure and 28-day mortality in patients with cirrhosis. Methods Hospitalized patients with cirrhosis with and without orga

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Balamir, Ilhan, Ihsan Ates, Canan Topcuoglu, and Turan Turhan. "Association of Endocan, Ischemia-Modified Albumin, and hsCRP Levels With Endothelial Dysfunction in Type 2 Diabetes Mellitus." Angiology 69, no. 7 (2017): 609–16. http://dx.doi.org/10.1177/0003319717740781.

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We investigated the relationship of ischemia-modified albumin (IMA) and high-sensitivity C-reactive protein (hsCRP) levels with direct (endocan) and indirect (carotid intima–media thickness [cIMT] and 24 hours urine protein excretion) endothelial dysfunction indicators in type 2 diabetes mellitus (T2DM). Patients with T2DM (n = 88) and 88 healthy individuals were included in the study. The median endocan (475.15 vs 216.37 pg/mL; P < .001, respectively) and hsCRP (10.74 vs 3.11 mg/L; P < .001, respectively) and the mean IMA (0.64 ± 0.12 vs 0.51 ± 0.12 absorbance units; P < .001, respec

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Zakharyan, E. A., O. Yu Gritskevich, R. E. Ibragimova, and P. E. Grigoriev. "Correlation of Serum Endocan Level With Apoptosis Indicators and Severity of Atherosclerotic Lesions of Coronary Arteries in Patients With Coronary Heart Disease." Kardiologiia 63, no. 11 (2023): 12–20. http://dx.doi.org/10.18087/cardio.2023.11.n2570.

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Aim To study the relationship of blood serum concentration of endocan with indexes of apoptosis and clinical and instrumental characteristics of patients with ischemic heart disease (IHD).Material and methods The study included 176 subjects (105 men and 71 women). 150 of them were diagnosed with IHD and 26 were healthy volunteers. Anthropometric measurements, coronary angiography, echocardiography, duplex ultrasound scanning of extracranial parts of the brachiocephalic arteries were performed for all patients. Concentrations of endocan (ng / ml), glucose (mmol / l), and apoptotic markers Bcl-2

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Munteanu, Mihaela. "MACE prediction in patients with STEMI and NSTEMI: from classic to novel markers in the estimation of coronary microcirculation disorder." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 78, no. 1 (2024): 7–16. http://dx.doi.org/10.52692/1857-0011.2024.1-78.01.

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Evaluation of classic and novel markers of coronary microcirculatory disorder (CMD) which have a predictive value on the risk of major cardiovascular event (MACE) in patients with STEMI and NSTEMI. Material and methods. The research included the retrospective analysis of a prospective observational study carried out on 600 patients, of which have been formed equal 4 groups of 80 patients (STEMI+MACE; STEMI-MACE; NSTEMI+MACE; NSTEMI-MACE) in which the collected blood on the 5-th day after angioplasty, the circulating level of 16 markers referring to CMD in the field of estimating endothelial dy

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Dallio, Marcello, Mario Masarone, Giuseppe Gerardo Caprio, et al. "Endocan Serum Levels in Patients with Non-Alcoholic Fatty Liver Disease with or without Type 2 Diabetes Mellitus: A Pilot Study." Journal of Gastrointestinal and Liver Diseases 26, no. 3 (2017): 261–68. http://dx.doi.org/10.15403/jgld.2014.1121.263.dal.

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Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is emerging as an independent cardiovascular risk factor. Recently, Endocan has been studied as an early marker of endothelial dysfunction. Our aim was to evaluate Endocan serum levels in patients with NAFLD with or without type 2 diabetes mellitus.Method: We enrolled 56 patients: 19 with NAFLD and 37 with type 2 diabetes mellitus with or without NAFLD, and compared them to 25 healthy controls. Endocan serum level was measured by using the ELISA EndoMark assay.Results: Endocan level was significantly higher in NAFLD subjects, com

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Zonda, Gabriela I., Radu Zonda, Andrei T. Cernomaz, Luminita Paduraru, and Bogdan D. Grigoriu. "Endocan serum concentration in uninfected newborn infants." Journal of Infection in Developing Countries 13, no. 09 (2019): 817–22. http://dx.doi.org/10.3855/jidc.11660.

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Introduction: Endocan is a specific endothelial mediator involved in the inflammatory response. Its role in the diagnosis of sepsis has been studied in adult patients and late onset neonatal sepsis. The clinical signs of early onset sepsis (EOS) are nonspecific and routinely used biomarkers, such as C-reactive protein and procalcitonin, have low sensitivity, specificity and positive predictive value. Endocan could be useful as a biomarker for diagnosis of EOS, but at present normal range values for this molecule have not been reported. The aim of this study is to establish the normal values ra

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Elkamshoushi, Abdel Aal M., Eman M. Hassan, Amr M. El Abd, Seham Z. Hassan, and Amer A. Maher. "Serum endocan as a predictive biomarker of cardiovascular risk in erectile dysfunction patients." Andrologia 50, no. 10 (2018): e13113. http://dx.doi.org/10.1111/and.13113.

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Yıldız, Şükrü, Cihan Kaya, Asuman Gedikbaşı, et al. "Endocan as a predictor of increased cardiovascular risk during the menopausal transition period." Archives of Gynecology and Obstetrics 301, no. 6 (2020): 1553–60. http://dx.doi.org/10.1007/s00404-020-05520-7.

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