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Journal articles on the topic 'Endogenous Antioxidant'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Dipak, Sontakke* Vinod Chavare Praful Patil Om lole Dhananjay Popalghat. "A Study on Antioxidant from Natural Origin." International Journal of Scientific Research and Technology 2, no. 5 (2025): 600–613. https://doi.org/10.5281/zenodo.15529360.

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Antioxidants Are The Defense System Of The Body Against The Damage Of Reactive Oxygen Species, Which Is Normally Produced During The Various Physiological Processes In The Body. There Are Various Sources Of These Antioxidants Like Endogenous Antioxidant Present In The Body And Exogenous Food Source. In Recent Decades, Alternate Of Synthetic Food Antioxidants By Natural Ones Has Fostered Interest On Vegetable Sources And The Screening Of Inexpensive Raw Materials Particularly From The Agriculture For Identifying New Antioxidants. Polyphenols Are The Significant Plant Compounds With Antioxidant

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Andersson, Helena, Anette Karlsen, Rune Blomhoff, Truls Raastad, and Fawzi Kadi. "Active recovery training does not affect the antioxidant response to soccer games in elite female players." British Journal of Nutrition 104, no. 10 (2010): 1492–99. http://dx.doi.org/10.1017/s0007114510002394.

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Changes in plasma endogenous and dietary antioxidants and oxidative stress markers were studied following two 90 min elite female soccer games separated by 72 h of either active or passive recovery. The active recovery group (n 8) trained for 1 h at 22 and 46 h after the first game (low-intensity cycling and resistance training), while the passive group rested (n 8). Blood samples were taken before the games; immediately after the games; 21, 45 and 69 h after the first game; and immediately after the second game. The oxidative stress markers and antioxidants were not affected by active recover

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Memudu, Adejoke Elizabeth. "Androgenic Anabolic Steroids Perturb Hepatocellular Tissue Damage Mediated by Oxidative Stress in the Presence of Endogenous Antioxidant." Advances in Clinical Toxicology 9, no. 1 (2024): 1–13. http://dx.doi.org/10.23880/act-16000292.

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Objective of the study: Anabolic androgenic steroids (AASs) unlawfully misused for their anabolic effects has deleterious effects of major concerns in public health even in the presence of endogenously produced antioxidants. This study is to evaluate the interaction between AAS metabolites and endogenously produced superoxide dismutase (SOD) activity in AAS treatment and AAS abstinence. Materials and Methods: Twenty (20) adult male Wistar used were divided into four (4) groups, A and B served as the positive and negative control given normal saline and olive oil respectively, C and D was given

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Barden, Cynthia L., and William J. Bramlage. "PREHARVEST CONDITIONS, ENDOGENOUS ANTIOXIDANTS AND SCALD DEVELOPMENT." HortScience 27, no. 11 (1992): 1159c—1159. http://dx.doi.org/10.21273/hortsci.27.11.1159c.

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During the harvest season apples ripen and develop scald resistance. In the Northeast they usually are also exposed to cool temperatures as they mature and ripen. Experiments were conducted to study the effects of cool temperature, light and maturity on the endogenous antioxidants and subsequent scald development in Cortland and Delicious apples. Total lipid-soluble antioxidant activity in apple peel at harvest generally increased as scald incidence after storage decreased. Yet, α tocopherol, ascorbic acid and total water-soluble reducing capacity were not closely related to scald development.

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Tabet, Naji, David Mantle, Zuzana Walker, and Martin Orrell. "Endogenous Antioxidant Activities in Relation to Concurrent Vitamins A, C, and E Intake in Dementia." International Psychogeriatrics 14, no. 1 (2002): 7–15. http://dx.doi.org/10.1017/s1041610202008232.

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Previous reports on the activities of essential endogenous antioxidants such as superoxide dismutase, catalase, and glutathione in dementia patients have not included a simultaneous quantitative assessment of dietary antioxidant intake. This is important because the reported differences in endogenous antioxidant levels among dementia patients may have reflected variations in the total antioxidants' intake. In this study we measured the levels of antioxidant vitamins A, C, and E in the diet of 81 dementia patients and controls at the same time as assessing blood levels of three endogenous antio

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Carsono, Nono, Sefren Geiner Tumilaar, Dikdik Kurnia, Diding Latipudin, and Mieke Hermiawati Satari. "A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species." Molecules 27, no. 19 (2022): 6774. http://dx.doi.org/10.3390/molecules27196774.

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Antioxidants are compounds that are able to inhibit the negative effects that come from free radicals. The phenomenon of imbalanced antioxidant production and the accumulation of free radicals in cells and tissues can cause oxidative stress. Excessive free radicals that enter the body cannot be warded off by endogenous antioxidant compounds so that the required antioxidant compounds can come from the outside, which helps in the performance of endogenous antioxidants. Antioxidants that come from outside consist of synthetic and natural antioxidants; however, synthetic antioxidants are not an op

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Romanowitz, Daniel, Joshua Zeichner, Edward Lain, et al. "Evaluation of Antioxidants’ Ability to Enhance Hyaluronic Acid-Based Topical Moisturizers." SKIN The Journal of Cutaneous Medicine 8, no. 1 (2024): s348. http://dx.doi.org/10.25251/skin.8.supp.348.

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Introduction: Hyaluronic acid (HA) is a unique molecule with multiple biological activities. In skin, HA plays an essential role as a humectant, capable of binding up to 1000 times its mass with water, leading to both skin moisturization and extracellular matrix rigidity. HA concentration and synthesis decreases significantly in aging skin, due to exogenous and endogenous factors, including photoaging and HA metabolism, respectively. A key driver for HA degradation and decrease in concentration is mediated via the induction of reactive oxygen species (ROS) and other free radicals. In this stud

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KOJIMA, SHUJI. "Neopterin as an Endogenous Antioxidant." Eisei kagaku 42, no. 4 (1996): 273–84. http://dx.doi.org/10.1248/jhs1956.42.273.

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Rosenfeld, Warren, and Luzminda Concepcion. "Endogenous antioxidant defenses in neonates." Journal of Free Radicals in Biology & Medicine 2, no. 4 (1986): 295–98. http://dx.doi.org/10.1016/s0748-5514(86)80013-7.

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Kojima, Shuji, Takeshi Icho, Yoshio Kajiwara, and Kazuhiko Kubota. "Neopterin as an endogenous antioxidant." FEBS Letters 304, no. 2-3 (1992): 163–66. http://dx.doi.org/10.1016/0014-5793(92)80610-s.

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Velkovska, Teodora M., and Adelaida L. Ruseva. "Antioxidant status in patients with hyperplasia and prostate cancer." Journal of Biomedical and Clinical Research 17, no. 2 (2024): 167–76. http://dx.doi.org/10.3897/jbcr.e125424.

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This review aims to briefly describe and summarize data from various studies on the role and the link between serum Total Antioxidant Status (TAS) levels in patients with BPH and PC, as well as other more widely available endogenous antioxidants, the levels of markers of inflammation (CRP, Leuc.), as well as the link between the values of endogenous antioxidants and various harmful factors. Their levels and adequate assessment could help in the proper management of patients with BPH and PC, as well as in reducing morbidity.

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Velkovska, Teodora M., and Adelaida L. Ruseva. "Antioxidant status in patients with hyperplasia and prostate cancer." Journal of Biomedical and Clinical Research 17 (October 8, 2024): 167–76. https://doi.org/10.3897/jbcr.e125424.

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This review aims to briefly describe and summarize data from various studies on the role and the link between serum Total Antioxidant Status (TAS) levels in patients with BPH and PC, as well as other more widely available endogenous antioxidants, the levels of markers of inflammation (CRP, Leuc.), as well as the link between the values of endogenous antioxidants and various harmful factors. Their levels and adequate assessment could help in the proper management of patients with BPH and PC, as well as in reducing morbidity.

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Korczowska-Łącka, Izabela, Bartosz Słowikowski, Thomas Piekut, et al. "Disorders of Endogenous and Exogenous Antioxidants in Neurological Diseases." Antioxidants 12, no. 10 (2023): 1811. http://dx.doi.org/10.3390/antiox12101811.

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In diseases of the central nervous system, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and even epilepsy and migraine, oxidative stress load commonly surpasses endogenous antioxidative capacity. While oxidative processes have been robustly implicated in the pathogenesis of these diseases, the significance of particular antioxidants, both endogenous and especially exogenous, in maintaining redox homeostasis requires further research. Among endogenous antioxidants, enzymes such as catalase, superoxide dismuta

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Rodella, Umberto, Claudia Honisch, Claudio Gatto, Paolo Ruzza, and Jana D’Amato Tóthová. "Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases." Nutrients 15, no. 10 (2023): 2283. http://dx.doi.org/10.3390/nu15102283.

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This review aims to discuss the delicate balance between the physiological production of reactive oxygen species and the role of antioxidant nutraceutical molecules in managing radicals in the complex anatomical structure of the eye. Many molecules and enzymes with reducing and antioxidant potential are present in different parts of the eye. Some of these, such as glutathione, N-acetylcysteine, α-lipoic acid, coenzyme Q10, and enzymatic antioxidants, are endogenously produced by the body. Others, such as plant-derived polyphenols and carotenoids, vitamins B2, C, and E, zinc and selenium, and o

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Martínez-Noguera, Francisco Javier, Pedro E. Alcaraz, Raquel Ortolano-Ríos, Stéphane P. Dufour, and Cristian Marín-Pagán. "Differences between Professional and Amateur Cyclists in Endogenous Antioxidant System Profile." Antioxidants 10, no. 2 (2021): 282. http://dx.doi.org/10.3390/antiox10020282.

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Currently, no studies have examined the differences in endogenous antioxidant enzymes in professional and amateur cyclists and how these can influence sports performance. The aim of this study was to identify differences in endogenous antioxidants enzymes and hemogram between competitive levels of cycling and to see if differences found in these parameters could explain differences in performance. A comparative trial was carried out with 11 professional (PRO) and 15 amateur (AMA) cyclists. All cyclists performed an endogenous antioxidants analysis in the fasted state (visit 1) and an increment

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Zakaria, Zainul Amiruddin, Noorsyaza Eddrina Kamsani, Roro Azizah, and Lilis Sulistyorini. "Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 21, no. 1 (2022): 66–80. http://dx.doi.org/10.37360/blacpma.22.21.1.04.

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Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous ant

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Shoker, Roaa M. H., Wasan Hamza Al-Shammery, and S. R. Al-Aidy. "A Review Article: Free Radical and Replacement Synthetic Antioxidant by Natural Antioxidant." Journal for Research in Applied Sciences and Biotechnology 2, no. 2 (2023): 206–11. http://dx.doi.org/10.55544/jrasb.2.2.29.

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Free radical may be responsible of several pathophysiology disease for threatening human life, and they are produced from endogenous and exogenous sources. Using the balanced amount of nutritious diet lead to a good health, may be neutralizing or scavenging free radicals by antioxidants compounds. daily diet have large number of vitamin A, E and C, carotenoids, polyphenols, etc. as natural antioxidants, the main bases of them are fruits, cereals, vegetables, and beverages. Enzymatic and non-enzymatic antioxidant substances are two different kinds that lessen the reactions of free radicals. In

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Fu, Minghao, Kyung-Sik Yoon, Joohun Ha, Insug Kang, and Wonchae Choe. "Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health." Antioxidants 14, no. 2 (2025): 203. https://doi.org/10.3390/antiox14020203.

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The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity and its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, and exacerbating inflammation and insulin resistance. Antioxidants, classified as endogenous (e.g., glutathione, superoxide dismutase, and catalase) and exogenous (e.g., polyphenols, flavonoids, and vit

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Kumar, Vinay, Ahmed Abdullah Khan, Anu Tripathi, Praveen K. Dixit, and U. K. Bajaj. "Role of oxidative stress in various diseases: Relevance of dietary antioxidants." Journal of Phytopharmacology 4, no. 2 (2015): 126–32. http://dx.doi.org/10.31254/phyto.2015.4213.

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Oxidative stress plays important role in the pathophysiology of various diseases. Oxidative stress is caused in body due to an imbalance between the activities of endogenous pro-oxidative enzymes. Cellular antioxidants are known to change their redox state and they can be targeted for destruction, regulate oxidative processes involved signal transduction, effect gene expression and the pathways of cell proliferation and death. Oxidants and antioxidants play an important role in maintaining a balance between free radicals produced by metabolism or derived from environmental sources and the anti

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Zazuli, Zulfan, Rika Hartati, Cornelia Rosasepti Rowa, Sukmadjaja Asyarie, and Satrialdi. "The Potential Application of Nanocarriers in Delivering Topical Antioxidants." Pharmaceuticals 18, no. 1 (2025): 56. https://doi.org/10.3390/ph18010056.

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The imbalance in the production of reactive oxygen species (ROS) with endogenous antioxidant capacity leads to oxidative stress, which drives many disorders, especially in the skin. In such conditions, supplementing exogenous antioxidants may help the body prevent the negative effect of ROS. However, the skin, as the outermost barrier of the body, provides a perfect barricade, making the antioxidant delivery complicated. Several strategies have been developed to enhance the penetration of antioxidants through the skin, one of which is nanotechnology. This review focuses on utilizing several na

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Balendra, Vyshnavy, and Sandeep Kumar Singh. "Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease." Open Biology 11, no. 6 (2021): 210013. http://dx.doi.org/10.1098/rsob.210013.

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Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of exogenous and endogenous antioxidants to maintain homeostasis. Superoxide dismutase (SOD) is an endogenous enzymatic antioxidant that converts superoxide ions to hydrogen peroxide in cells. SOD supplementation in mice prevented cognitive decline in stress-induced cells by reducing lipid peroxidation and maintaining neurogenesis in the hippocampus. Furthermore, SOD decreased expression of BACE1 while reducing plaque burde

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Barden, Cynthia L., and W. J. Bramlage. "THE EFFECTS OF PREHARVEST ENVIRONMENTAL FACTORS ON ENDOGENOUS ANTIOXIDANTS AND SCALD DEVELOPMENT IN APPLES." HortScience 25, no. 9 (1990): 1146F—1146. http://dx.doi.org/10.21273/hortsci.25.9.1146.

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Superficial scald development on apples is related to preharvest environmental conditions, perhaps through effects on endogenous antioxidant concentrations In 1989 we examined effects of maturity, light, and preharvest temperatures (< 10°C) on endogenous antioxidant levels in the fruit at harvest and on scald development after long-term storage in 0°C air. Cortland apple trees were sprayed with 500 ppm ethephon 1 month before normal harvest to create maturity differences. Fruit on other Cortland trees were bagged 1 month prior to harvest to reduce light interception. Samples also were harve

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Barden, Cynthia L., and W. J. Bramlage. "THE EFFECTS OF PREHARVEST ENVIRONMENTAL FACTORS ON ENDOGENOUS ANTIOXIDANTS AND SCALD DEVELOPMENT IN APPLES." HortScience 25, no. 9 (1990): 1146f—1146. http://dx.doi.org/10.21273/hortsci.25.9.1146f.

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Superficial scald development on apples is related to preharvest environmental conditions, perhaps through effects on endogenous antioxidant concentrations In 1989 we examined effects of maturity, light, and preharvest temperatures (< 10°C) on endogenous antioxidant levels in the fruit at harvest and on scald development after long-term storage in 0°C air. Cortland apple trees were sprayed with 500 ppm ethephon 1 month before normal harvest to create maturity differences. Fruit on other Cortland trees were bagged 1 month prior to harvest to reduce light interception. Samples also were harve

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Poljsak, B. "Strategies for Reducing or Preventing the Generation of Oxidative Stress." Oxidative Medicine and Cellular Longevity 2011 (2011): 1–15. http://dx.doi.org/10.1155/2011/194586.

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The reduction of oxidative stress could be achieved in three levels: by lowering exposure to environmental pollutants with oxidizing properties, by increasing levels of endogenous and exogenous antioxidants, or by lowering the generation of oxidative stress by stabilizing mitochondrial energy production and efficiency. Endogenous oxidative stress could be influenced in two ways: by prevention of ROS formation or by quenching of ROS with antioxidants. However, the results of epidemiological studies where people were treated with synthetic antioxidants are inconclusive and contradictory. Recent

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Salim, Fatimah, Noorazlina Adnan, Nor Syarmila Shuib, and Raihana Mohd Yusof. "Antioxidants for Health Management." Jurnal Intelek 17, no. 1 (2022): 55. http://dx.doi.org/10.24191/ji.v17i1.15851.

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Antioxidants are technically reductant molecules that prevent the oxidation of other molecules. As other living systems, human biological molecules are also prone to oxidation reactions. In order to repair all of the oxidation damage, human body is naturally producing antioxidants or known as endogenous antioxidant. Unfortunately, the body’s production of antioxidants declines with age and this is found to be a strong factor in contributing to premature aging and degenerative diseases. Researchers have found that exogenous antioxidants which are obtained from foods may work together with endog

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Taing, Leakkhaing, Jittima Tomacha, Piya Prajumwongs, et al. "Evaluation of Antioxidant and Anti-Aging Activities of Thai Rice Germ Extracts." Trends in Sciences 22, no. 4 (2025): 9348. https://doi.org/10.48048/tis.2025.9348.

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Aging in humans is a natural process characterized by the accumulation of oxygen-derived free radicals, leading to cellular and tissue damage and aging-related diseases. Bioactive compounds from plants, known for their antioxidant properties, can mitigate the effects of aging by scavenging these free radicals. The present study aimed to explore the antioxidant and anti-aging properties of commercial rice germ extracts. Fifteen types of extensively commercial rice germ (RG) products from Thailand were coded as RG1 - RG15. These products were assessed for phenolic content and antioxidant activit

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Naguib, Sarah, Carlisle R. DeJulius, Jon R. Backstrom, et al. "Intraocular Sustained Release of EPO-R76E Mitigates Glaucoma Pathogenesis by Activating the NRF2/ARE Pathway." Antioxidants 12, no. 3 (2023): 556. http://dx.doi.org/10.3390/antiox12030556.

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Erythropoietin (EPO) is neuroprotective in multiple models of neurodegenerative diseases, including glaucoma. EPO-R76E retains the neuroprotective effects of EPO but diminishes the effects on hematocrit. Treatment with EPO-R76E in a glaucoma model increases expression of antioxidant proteins and is neuroprotective. A major pathway that controls the expression of antioxidant proteins is the NRF2/ARE pathway. This pathway is activated endogenously after elevation of intraocular pressure (IOP) and contributes to the slow onset of pathology in glaucoma. In this study, we explored if sustained rele

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Martemucci, Giovanni, Ciro Costagliola, Michele Mariano, Luca D’andrea, Pasquale Napolitano, and Angela Gabriella D’Alessandro. "Free Radical Properties, Source and Targets, Antioxidant Consumption and Health." Oxygen 2, no. 2 (2022): 48–78. http://dx.doi.org/10.3390/oxygen2020006.

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Free radicals have acquired growing importance in the fields of biology and medicine. They are produced during many different endogenous and exogenous processes. Mitochondria are the main source of endogenous reactive oxygen species (ROS) produced at cell level. The overproduction of free radicals can damage macromolecules such as nucleic acids, proteins and lipids. This leads to tissue damage in various chronic and degenerative diseases. Antioxidants play a crucial role in the body’s defense against free radicals. This review concerns the main properties of free radicals, their sources and de

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Eaton, Simon. "The biochemical basis of antioxidant therapy in critical illness." Proceedings of the Nutrition Society 65, no. 3 (2006): 242–49. http://dx.doi.org/10.1079/pns2006501.

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During critical illness free radical production may increase as a result of, for example, sepsis or tissue trauma. In addition, because of a potential for increased losses, and the possibility of inadequate nutrition, the antioxidant defences of the body may become compromised. Thus, the delicate balance between free radicals and antioxidants may be disturbed. Various nutritional and pharmacological strategies to enhance antioxidant defences have been proposed, which aim either to maintain or enhance endogenous antioxidant stores or to provide alternative antioxidant agents. Trace elements and

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Craciun, Ioana, and Florinel Gheorghe Brudasca. "Unravelling the Antioxidant Potential of Resveratrol and Quercetin in Animal Models: A Comprehensive Review." Cluj Veterinary Journal 28, no. 1 (2023): 20–27. http://dx.doi.org/10.52331/cvj.v28i1.44.

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 Resveratrol and quercetin are naturally occurring polyphenolic compounds widely studied for their potential health benefits, particularly their antioxidant properties. This abstract provides an overview of the extensive research conducted on resveratrol and quercetin as antioxidants in animal models, highlighting their mechanisms of action and therapeutic potential. Animal models, such as rodents, have been instrumental in elucidating the oxidative stress pathway and evaluating the efficacy of various antioxidants. Resveratrol and quercetin have demonstrated significant antioxidant effe

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Isamukhamedova, Dildora Rakhmatillaevna. "THE EFFECT OF BIOLOGICALLY ACTIVE SUBSTANCES ON THE BODY'S ANTIOXIDANT SYSTEM DURING OXIDATIVE STRESS." American Journal of Advanced Scientific Research (AJASR) 2, no. 9 (2025): 149–53. https://doi.org/10.5281/zenodo.15235125.

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Oxidative stress plays a critical role in the pathogenesis of various chronicdiseases and aging processes. The body’s antioxidant defense system is responsiblefor maintaining redox balance and protecting cellular components from oxidativedamage. This study investigates the impact of biologically active substances (BAS),including vitamins, polyphenols, and other antioxidants, on the functionality andefficiency of the endogenous antioxidant system during oxidative stress. Utilizingboth in vivo and in vitro models, the study evaluates how BAS modulates oxidativemarkers and improves antioxid

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Povetkina, S. R., A. K. Zastrozhina, N. A. Drozhzhina, E. A. Shlepotina, E. A. Piven, and M. N. Dubina. "Creatine supplementation effect on oxidative stress and physical exercise." Sanitarnyj vrač (Sanitary Doctor), no. 12 (December 7, 2023): 797–805. http://dx.doi.org/10.33920/med-08-2312-04.

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This article explores the role of creatine supplementation in the processes of oxidative stress during exercise. Oxidative stress is the result of an imbalance between the formation and elimination of reactive oxygen species (ROS), which degrade biogenic substances: deoxyribonucleic acid (DNA), proteins, lipids, and can lead to tissue damage. In the course of physical activity, there is a physiological increase in the processes of oxidative stress. Although intense exercise contributes to oxidative damage to muscle fibers, regular physical activity enhances the ability of cells to eliminate ex

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Lalita A and Oviya Nilaa M K. "Dietary antioxidants: An overview." IP Journal of Nutrition, Metabolism and Health Science 7, no. 4 (2024): 156–58. https://doi.org/10.18231/j.ijnmhs.2024.029.

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The substances which inhibit oxidation are called as antioxidants. They are also known as free radical scavengers. The decrease in concentration of antioxidant is termed as oxidative stress. The presence of antioxidants decreases the risk of inflammation, liver disease, cardiovascular, cataract, nephrotoxicity and neurodegenerative diseases. They are categorized as exogenous and endogenous. Endogenous antioxidants include enzymatic and non-enzymatic. Enzymatic antioxidants are glutathione peroxidase, superoxide dismutase and catalase whereas non-enzymatic are uric acid, metanonin lipoic acid,

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Fratta Pasini, Anna Maria, and Luciano Cominacini. "Potential Benefits of Antioxidant Phytochemicals on Endogenous Antioxidants Defences in Chronic Diseases." Antioxidants 12, no. 4 (2023): 890. http://dx.doi.org/10.3390/antiox12040890.

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Marčetić, Mirjana, and Jelena Arsenijević. "Antioxidant activity of plant secondary metabolites." Arhiv za farmaciju 73, no. 4 (2023): 264–77. http://dx.doi.org/10.5937/arhfarm73-45560.

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Oxidative stress can induce the development of many different disorders. Plant secondary metabolites may act as antioxidants by neutralisation of free radicals and by stimulation of endogenous antioxidant mechanisms. One of the important secondary plant metabolites with antioxidant activity are polyphenols. They can exert activity through different mechanisms depending on their structure. Polyphenols are widely present in herbal drugs, and some of the commonly used ones are aronia berry (Aroniae fructus) and bilberry fruit (Myrtilli fructus), both rich in anthocyanins and tannins and with high

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Tantowi, Ferdy, and David Limanan. "Antioxidant Test, Total Alkaloid Content, Antimitosis Test and HPTLC Test of Chamomile Flower Extract (Matricaria Chamomilla L.)." Devotion Journal of Community Service 4, no. 1 (2023): 78–87. http://dx.doi.org/10.36418/dev.v4i1.351.

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Oxygen is one of the supports of multicellular life and is necessary for aerobic metabolism. However, the use of oxygen can produce by-products, one of which is reactive oxygen species (ROS) which can also increase due to external factors such as exposure to ionizing rays, and vehicle smoke. When reactive oxygen species levels are high, the body can experience a condition called oxidative stress, which is a condition that can cause tissue damage. To overcome this, antioxidants are needed, namely compounds that can donate electrons to free radicals to neutralize their effects. Antioxidants are

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SUN, Xue-jun. "Hydrogen-an endogenous antioxidant in the body." Academic Journal of Second Military Medical University 28, no. 3 (2008): 233–35. http://dx.doi.org/10.3724/sp.j.1008.2008.00233.

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Rahman AHM, Mahmudur, Farrah Shafeera Ibrahim, Zulkhairi Amom, and Adel A. Amran. "THE ANTIOXIDANT MECHANISM IN THE PREVENTION OF TYPE 2 DIABETES AND ITS COMPLICATIONS: A NARRATIVE REVIEW." Journal of Health and Translational Medicine sp2023, no. 2 (2023): 399–410. http://dx.doi.org/10.22452/jummec.sp2023no2.45.

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Type 2 diabetes mellitus (T2DM) is considered a chronic metabolic disease in which oxidative stress plays a vital part in the pathogenesis of diabetes. Essentially, hyperglycemia instigates the auto-oxidation of glucose to free radicals. The free radicals overwhelm endogenous antioxidant defense in macrovascular and microvascular dysfunctions. The antioxidants (such as vitamin C and α-lipoic acid) effectively reduce diabetic complications; they are used to treat and decrease the complication of diabetes mellitus. Supplementations with antioxidants and medicinal plants that possess antioxidant

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Seneviratne, Charita K., Timao Li, Neelam Khaper, and Pawan K. Singal. "Effects of methionine on endogenous antioxidants in the heart." American Journal of Physiology-Heart and Circulatory Physiology 277, no. 6 (1999): H2124—H2128. http://dx.doi.org/10.1152/ajpheart.1999.277.6.h2124.

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The deficiency of methionine, an essential amino acid, is associated with cardiovascular lesions. Because different types of cardiac pathologies are caused by a decrease in antioxidants, we examined the effects of methionine on myocardial antioxidant enzymes in hemodynamically assessed rats that were treated with methionine (10 mg/ml) in drinking water for 12, 24, and 48 h. Glutathione peroxidase (GSHPx) activity was significantly increased to 150.5 ± 12.2 and 191.7 ± 13.7% of the control value at 12 and 24 h, respectively, followed by a decline to 120 ± 24.6% at 48 h. The mRNA levels of GSHPx

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Ashok, Anushruti, Syed Suhail Andrabi, Saffar Mansoor, Youzhi Kuang, Brian K. Kwon, and Vinod Labhasetwar. "Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation." Antioxidants 11, no. 2 (2022): 408. http://dx.doi.org/10.3390/antiox11020408.

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Free radicals are formed as a part of normal metabolic activities but are neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This redox balance is disrupted in certain neuropathophysiological conditions, causing oxidative stress, which is implicated in several progressive neurodegenerative diseases. Following neuronal injury, secondary injury progression is also caused by excessive production of free radicals. Highly reactive free radicals, mainly the reactive oxygen species (ROS) and reactive nitrogen species (RNS), damage the cell membrane

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Ayubi, Novadri, Junian Cahyanto Wibawa, Mohammed Aljunaid, Procopio B. Dafun Jr., and Jiang Wen Ming. "Analyzing Superoxide Dismutase as A Molecular Signal Transducer that is Beneficial for Health during Physical Exercise: A Systematic Review." AL-Kindy College Medical Journal 20, no. 2 (2024): 82–88. http://dx.doi.org/10.47723/rxr2gb93.

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Physical activity has been considered as one factor that increases oxidative stress. However, the body's natural reaction to exercise might provide more contribution to increase the levels of endogenous antioxidants, including superoxide dismutase. This study aimed to determine how exercise affects the increase in superoxide dismutase enzyme. To reach the objective, the study traced a number of journal databases, including Embase, Pub med, Web of Science, Science Direct, and Scopus. The study considered a number of factors, especially studies that investigated antioxidants, physical activity,

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Umapathy, Ankita, Paul Donaldson, and Julie Lim. "Antioxidant Delivery Pathways in the Anterior Eye." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/207250.

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Tissues in the anterior segment of the eye are particular vulnerable to oxidative stress. To minimise oxidative stress, ocular tissues utilise a range of antioxidant defence systems which include nonenzymatic and enzymatic antioxidants in combination with repair and chaperone systems. However, as we age our antioxidant defence systems are overwhelmed resulting in increased oxidative stress and damage to tissues of the eye and the onset of various ocular pathologies such as corneal opacities, lens cataracts, and glaucoma. While it is well established that nonenzymatic antioxidants such as ascor

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Vidović, Bojana. "Dietary antioxidants and health effects: What are their optimal intakes?" Arhiv za farmaciju 73, no. 4 (2023): 278–91. http://dx.doi.org/10.5937/arhfarm73-45552.

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A well-balanced diet provides many compounds with antioxidant properties, such as vitamins, minerals, provitamins (e.g., b-carotene), and phytochemicals (e.g., carotenoids, polyphenols, organosulfur compounds). In addition to direct antioxidants, foods indirectly support the endogenous defense system, by providing substrates for the synthesis of glutathione, antioxidant defense enzymes, metal-binding proteins, or modulators of redox-dependent signaling pathways. Epidemiological studies indicate that higher intakes and circulating concentrations of vitamins C, E, carotenoids, and flavonoids ref

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Pastor, Rosario, and Josep A. Tur. "Antioxidant Supplementation and Adaptive Response to Training: A Systematic Review." Current Pharmaceutical Design 25, no. 16 (2019): 1889–912. http://dx.doi.org/10.2174/1381612825666190701164923.

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Background: Antioxidant supplementation has become a common practice among athletes to theoretically achieve a reduction in oxidative stress, promote recovery and improve performance. Objective: To assess the effect of antioxidant supplements on exercise. Methods: A systematic literature search was performed up to January 2019 in MEDLINE via EBSCO and Pubmed, and in Web of Sciences based on the following terms: “antioxidants” [Major] AND “exercise” AND “adaptation”; “antioxidant supplement” AND “(exercise or physical activity)” AND “(adaptation or adjustment)” [MesH]. Thirty-six articles were

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Singh, Poornima, Virginia Paul, and Ritu Dubey. "Antioxidant Foods." International Journal of Advances in Agricultural Science and Technology 9, no. 4 (2022): 1–7. http://dx.doi.org/10.47856/ijaast.2022.v09i04.001.

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Antioxidant is any substance that delays, prevents or removes oxidative damage to a target molecule. It can be found in many foods, including fruits and vegetables. The role of antioxidants in foods is to retard or control oxidation. The process of autoxidation and development of rancidity in foods involves a free radical chain mechanism via initiation, propagation and termination steps. While radicals are produced in the ‘initiation’ step, they react with unsaturated fatty acids by abstracting a hydrogen atom from a site which requires the least energy that is the allylic or diallylic positio

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Aranda-Rivera, Ana Karina, Alfredo Cruz-Gregorio, Yalith Lyzet Arancibia-Hernández, Estefani Yaquelin Hernández-Cruz, and José Pedraza-Chaverri. "RONS and Oxidative Stress: An Overview of Basic Concepts." Oxygen 2, no. 4 (2022): 437–78. http://dx.doi.org/10.3390/oxygen2040030.

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Oxidative stress (OS) has greatly interested the research community in understanding damaging processes occurring in cells. OS is triggered by an imbalance between reactive oxygen species (ROS) production and their elimination by the antioxidant system; however, ROS function as second messengers under physiological conditions. ROS are produced from endogenous and exogenous sources. Endogenous sources involve mitochondria, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), oxidases (NOXs), endoplasmic reticulum (ER), xanthine oxidases (XO), endothelial nitric oxide synthase (eNOs), a

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Waldman, Hunter. "Astaxanthin Supplementation as a Potential Strategy for Enhancing Mitochondrial Adaptations in the Endurance Athlete: An Invited Review." Nutrients 16, no. 11 (2024): 1750. http://dx.doi.org/10.3390/nu16111750.

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Astaxanthin, a potent antioxidant found in marine organisms such as microalgae and krill, may offer ergogenic benefits to endurance athletes. Originally used in fish feed, astaxanthin has shown a greater ability to mitigate various reactive oxygen species and maintain the structural integrity of mitochondria compared to other exogenous antioxidants. More recent work has shown that astaxanthin may improve: (1) cycling time trial performance, (2) cardiorespiratory measures such as submaximal heart rate during running or cycling, (3) recovery from delayed-onset muscle soreness, and (4) endogenous

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Panova, Ina G., and Alexander S. Tatikolov. "Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)." Pharmaceuticals 16, no. 8 (2023): 1077. http://dx.doi.org/10.3390/ph16081077.

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The use of conventional contrast media for diagnostic purposes (in particular, Gd-containing and iodinated agents) causes a large number of complications, the most common of which is contrast-induced nephropathy. It has been shown that after exposure to contrast agents, oxidative stress often occurs in patients, especially in people suffering from various diseases. Antioxidants in the human body can diminish the pathological consequences of the use of contrast media by suppressing oxidative stress. This review considers the research studies on the role of antioxidants in preventing the negativ

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Bruns, Danielle R., Sarah E. Ehrlicher, Shadi Khademi, et al. "Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise." Journal of Applied Physiology 125, no. 2 (2018): 661–71. http://dx.doi.org/10.1152/japplphysiol.00277.2018.

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Maintaining proteostasis is a key mechanism for preserving cell function. Exercise-stimulated proteostasis is regulated, in part, by redox-sensitive signaling. Several studies suggest that supplementation with exogenous antioxidants blunts exercise-induced cellular adaptations, although this conclusion lacks consensus. Our group uses a fundamentally different approach to maintain redox balance by treatment with bioactive phytochemicals to activate the transcription factor nuclear factor (erythroid-derived 2)-like 2 and downstream endogenous antioxidant pathways. We hypothesized that vitamin C

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Esquivel, Abigail R., Jenna C. Douglas, Rachel M. Loughran, et al. "Assessing the influence of curcumin in sex-specific oxidative stress, survival and behavior in Drosophila melanogaster." Journal of Experimental Biology 223, no. 22 (2020): jeb223867. http://dx.doi.org/10.1242/jeb.223867.

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ABSTRACTOxidative stress, which occurs from an imbalance of reactive oxygen and nitrogen species (RONS) and both endogenous and exogenous antioxidants, promotes aging and underlies sex-specific differences in longevity and susceptibility to age-related neurodegeneration. Recent evidence suggests that curcumin, a yellow pigment derived from turmeric and shown to exhibit antioxidant properties as a RONS scavenger, influences the regulation of genetic elements in endogenous antioxidant pathways. To investigate the role of curcumin in sex-specific in vivo responses to oxidative stress, Drosophila

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