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Relevant bibliographies by topics / Endogenous bioactive lipids

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Academic literature on the topic 'Endogenous bioactive lipids'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Endogenous bioactive lipids"

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Chiurchiù, Valerio, Marta Tiberi, Alessandro Matteocci, et al. "Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We?" International Journal of Molecular Sciences 23, no. 11 (2022): 6235. http://dx.doi.org/10.3390/ijms23116235.

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Lipids are not only constituents of cellular membranes, but they are also key signaling mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation, and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between the immune and nervous systems, and lipids can interact particularly with the aggregation and propagation of many pathogenic proteins that are well-renowned hallmarks of several neurodegenerative disorders, including Alzheimer’s (AD) and Parkinson’s (PD) dis

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Maccarrone, Mauro. "Deciphering Complex Interactions in Bioactive Lipid Signaling." Molecules 28, no. 6 (2023): 2622. http://dx.doi.org/10.3390/molecules28062622.

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Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspe

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Wan, Zhou, David F. Woodward, and W. Daniel Stamer. "Endogenous bioactive lipids and the regulation of conventional outflow facility." Expert Review of Ophthalmology 3, no. 4 (2008): 457–70. http://dx.doi.org/10.1586/17469899.3.4.457.

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Berger, Natascha, Hanna Allerkamp, and Christian Wadsack. "Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?" International Journal of Molecular Sciences 23, no. 12 (2022): 6851. http://dx.doi.org/10.3390/ijms23126851.

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The metabolic state of pregnant women and their unborn children changes throughout pregnancy and adapts to the specific needs of each gestational week. These adaptions are accomplished by the actions of enzymes, which regulate the occurrence of their endogenous substrates and products in all three compartments: mother, placenta and the unborn. These enzymes determine bioactive lipid signaling, supply, and storage through the generation or degradation of lipids and fatty acids, respectively. This review focuses on the role of lipid-metabolizing serine hydrolases during normal pregnancy and in p

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Wang, Yuren, Fernando Ramirez, Girija Krishnamurthy, et al. "High-Throughput Screening for the Discovery of Inhibitors of Fatty Acid Amide Hydrolase Using a Microsome-Based Fluorescent Assay." Journal of Biomolecular Screening 11, no. 5 (2006): 519–27. http://dx.doi.org/10.1177/1087057106288188.

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Fatty acid amide hydrolase (FAAH) is a membrane-associated enzyme that catalyzes the hydrolysis of several endogenous bioactive lipids, including anandamide (AEA), N-palmitoylethanolamine (PEA), oleamide, and N-oleoylethanolamine (OEA). These fatty acid amides participate in many physiological activities such as analgesia, anxiety, sleep modulation, anti inflammatory responses, and appetite suppression. Because FAAH plays an essential role in controlling the tone and activity of these endogenous bioactive lipids, this enzyme has been implicated to be a drug target for the therapeutic managemen

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Körner, Andreas, Enchen Zhou, Christoph Müller та ін. "Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution". Proceedings of the National Academy of Sciences 116, № 41 (2019): 20623–34. http://dx.doi.org/10.1073/pnas.1911992116.

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Targeting metabolism through bioactive key metabolites is an upcoming future therapeutic strategy. We questioned how modifying intracellular lipid metabolism could be a possible means for alleviating inflammation. Using a recently developed chemical probe (SH42), we inhibited distal cholesterol biosynthesis through selective inhibition of Δ24-dehydrocholesterol reductase (DHCR24). Inhibition of DHCR24 led to an antiinflammatory/proresolving phenotype in a murine peritonitis model. Subsequently, we investigated several omics layers in order to link our phenotypic observations with key metabolic

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Fava, Marina, Alessandro Leuti, and Mauro Maccarrone. "Lipid Signalling in Human Immune Response and Bone Remodelling under Microgravity." Applied Sciences 10, no. 12 (2020): 4309. http://dx.doi.org/10.3390/app10124309.

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Since the first Apollo mission in 1969, microgravity has been linked to many alterations of astronauts’ physiology, among which immunosuppression, altered inflammation and bone loss represent relevant examples. In the past 40 years, extensive investigations have been conducted in order to characterize the molecular mechanisms driving the alterations caused by prolonged weightlessness on human health. However, almost all studies eluded the role played by bioactive lipids, a vastly heterogeneous class of endogenous molecules, which, under normal conditions, control immune and bone homeostasis. T

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George, Alexandra, Melvin Gay, Robert Trengove, and Donna Geddes. "Human Milk Lipidomics: Current Techniques and Methodologies." Nutrients 10, no. 9 (2018): 1169. http://dx.doi.org/10.3390/nu10091169.

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Human milk contains a complex combination of lipids, proteins, carbohydrates, and minerals, which are essential for infant growth and development. While the lipid portion constitutes only 5% of the total human milk composition, it accounts for over 50% of the infant’s daily energy intake. Human milk lipids vary throughout a feed, day, and through different stages of lactation, resulting in difficulties in sampling standardization and, like blood, human milk is bioactive containing endogenous lipases, therefore appropriate storage is critical in order to prevent lipolysis. Suitable sample prepa

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Leuti, Alessandro, Marina Fava, Niccolò Pellegrini, et al. "Simulated Microgravity Affects Pro-Resolving Properties of Primary Human Monocytes." Cells 13, no. 1 (2024): 100. http://dx.doi.org/10.3390/cells13010100.

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Space-related stressors such as microgravity are associated with cellular and molecular alterations of the immune and inflammatory homeostasis that have been linked to the disorders that astronauts suffer from during their missions. Most of the research of the past 30 years has consistently established that innate adaptive immune cells represent a target of microgravity, which leads to their defective or dysfunctional activation, as well as to an altered ability to produce soluble mediators—e.g., cytokines/chemokines and bioactive lipids—that altogether control tissue homeostasis. Bioactive li

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Do, Thi Cam Van, Dang Thuan Tran, Truong Giang Le, and Quang Trung Nguyen. "Characterization of Endogenous Auxins and Gibberellins Produced by Chlorella sorokiniana TH01 under Phototrophic and Mixtrophic Cultivation Modes toward Applications in Microalgal Biorefinery and Crop Research." Journal of Chemistry 2020 (June 4, 2020): 1–11. http://dx.doi.org/10.1155/2020/4910621.

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Microalgae have been reported to produce endogenous phytohormones including auxins, gibberellins, cytokinins, brassinosteroids, and abscisic acid. Methanol residual released from microalgal lipid extraction usually contains a variety of bioactive compounds including the phytohormones; however, they are poorly characterized and used for other applications. This study aimed at investigating auxin, gibberellin, and cytokinin production of C. sorokiniana TH01 under phototrophic and mixtrophic cultivations. Moreover, endogenous auxins, gibberellins, and cytokinins in methanol residual obtained from

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Book chapters on the topic "Endogenous bioactive lipids"

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Felder, Christian C., Amie Nielsen, Eileen M. Briley, et al. "The Role of Anandamide and Related Fatty Acid Ethanolamides as Endogenous Ligands for the CB1 and CB2 Cannabinoid Receptors." In Frontiers in Bioactive Lipids. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-5875-0_22.

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Capdevila, J. H., Y. Jin, A. Karara, and J. R. Falck. "Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids." In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3520-1_3.

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Cakir, Oguz, and Mustafa Abdullah Yilmaz. "A Promising Bioactive Phytochemical; Rosmarinic Acid, Targets Nervous System Disorders." In Neurological Diseases and Treatments in Terms of Biochemistry. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359357.8.

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Rosmarinic acid (RA), a phenolic molecule found in culinary herbs, has shown potential therapeutic benefits for various neurodegenerative disorders due to its antiapoptotic, antioxidant, and anti-inflammatory properties. RA can reduce oxidative stress, prevent cytotoxicity, and protect against neurotoxicity caused by various substances. It also mitigates the effects of metal ions and prevents iron-induced neurotoxicity in neuroblastoma cells. RA’s potential to improve central nervous system disorders is growing worldwide. It has been shown to suppress GABA transaminase activity and reduce seiz

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Müller, S., and S. Nigam. "Enhancement by Staurosporine of PLA2-Activity and PAF-Biosynthesis in FMLP- Stimulated Human Neutrophils: Specific Role of Endogenously Synthesized PAF." In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3520-1_40.

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Shi, Congjian, Hongqin Yang, Zhengchao Wang, and Zhenghong Zhang. "Regulation of Exosomes in the Pathogenesis of Breast Cancer." In Global Women's Health [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95858.

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Extracellular vesicles (EVs) are a heterogeneous group of endogenous nanoscale vesicles that are secreted by various cell types. Based on their biogenesis and size distribution, EVs can be broadly classified as exosomes and microvesicles. Exosomes are enveloped by lipid bilayers with a size of 30–150 nm in diameter, which contain diverse biomolecules, including lipids, proteins and nucleic acids. Exosomes transport their bioactive cargoes from original cells to recipient cells, thus play crucial roles in mediating intercellular communication. Breast cancer is the most common malignancy among w

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Faraone, Immacolata, Daniela Russo, Fabiana Labanca, et al. "Antioxidant Activity Methods." In Methods for Preclinical Evaluation of Bioactive Natural Products. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123043123010003.

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Antioxidants are groups of substances able to prevent and delay the oxidation of easily oxidizable molecules and avoid free radicals’ formation. In living organisms, the main free radicals are reactive oxygen species and reactive nitrogen species. At low levels, they are involved in the regulation of diverse physiological processes, but an imbalance between free radicals and the ability of the body to eliminate them results in a pathological condition called oxidative/nitrosative stress. Oxidative/nitrosative stress causes damage to cellular structures such as lipids, nucleic acid, and protein

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Conference papers on the topic "Endogenous bioactive lipids"

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Sagliani, Kristen D., Nicholas S. Hill, Gregory Dolnikowski, et al. "Determination Of Endogenous Bioactive Lipid Profile In Experimental Pulmonary Hypertension." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4755.

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