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Journal articles on the topic 'Endogenous biosynthesis'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Kawada, Kojiro, Yuya Uchida, Ikuo Takahashi, et al. "Triflumizole as a Novel Lead Compound for Strigolactone Biosynthesis Inhibitor." Molecules 25, no. 23 (2020): 5525. http://dx.doi.org/10.3390/molecules25235525.

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Strigolactones (SLs) are carotenoid-derived plant hormones involved in the development of various plants. SLs also stimulate seed germination of the root parasitic plants, Striga spp. and Orobanche spp., which reduce crop yield. Therefore, regulating SL biosynthesis may lessen the damage of root parasitic plants. Biosynthetic inhibitors effectively control biological processes by targeted regulation of biologically active compounds. In addition, biosynthetic inhibitors regulate endogenous levels in developmental stage- and tissue-specific manners. To date, although some chemicals have been fou

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2

Sang, Ya Lin, Zhi Juan Cheng, and Xian Sheng Zhang. "Endogenous auxin biosynthesis andde novoroot organogenesis." Journal of Experimental Botany 67, no. 14 (2016): 4011–13. http://dx.doi.org/10.1093/jxb/erw250.

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Lim, Gah-Hyun, Se Won Kim, Jaihyunk Ryu, Si-Yong Kang, Jin-Baek Kim, and Sang Hoon Kim. "Upregulation of the MYB2 Transcription Factor is Associated with Increased Accumulation of Anthocyanin in the Leaves of Dendrobium bigibbum." International Journal of Molecular Sciences 21, no. 16 (2020): 5653. http://dx.doi.org/10.3390/ijms21165653.

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Orchids with colorful leaves and flowers have significant ornamental value. Here, we used γ-irradiation-based mutagenesis to produce a Dendrobium bigibbum mutant that developed purple instead of the normal green leaves. RNA sequencing of the mutant plant identified 2513 differentially expressed genes, including 1870 up- and 706 downregulated genes. The purple leaf color of mutant leaves was associated with increased expression of genes that encoded key biosynthetic enzymes in the anthocyanin biosynthetic pathway. In addition, the mutant leaves also showed increased expression of several famili

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Krump, Eric, Serge Picard, Joseph Mancini, and Pierre Borgeat. "Suppression of Leukotriene B4 Biosynthesis by Endogenous Adenosine in Ligand-activated Human Neutrophils." Journal of Experimental Medicine 186, no. 8 (1997): 1401–6. http://dx.doi.org/10.1084/jem.186.8.1401.

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Adenosine (Ado) has been shown to suppress several functional responses of human polymorphonuclear leukocytes (PMNs). The current study investigated whether endogenous Ado regulates the biosynthesis of leukotriene (LT)B4 in ligand-stimulated PMNs. Measurements of Ado in PMN resuspended in Hanks' buffered salt solution (HBSS) or plasma showed a cell concentration– and time–dependent accumulation of the nucleoside. The removal of endogenous Ado with either Ado deaminase or the blockade of its action by the Ado A2a receptor antagonist, 8-(3-chlorostyryl) caffeine, markedly increased LTB4 biosynth

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Bianco, C., B. Senatore, S. Arbucci, G. Pieraccini, and R. Defez. "Modulation of Endogenous Indole-3-Acetic Acid Biosynthesis in Bacteroids within Medicago sativa Nodules." Applied and Environmental Microbiology 80, no. 14 (2014): 4286–93. http://dx.doi.org/10.1128/aem.00597-14.

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ABSTRACTTo evaluate the dose-response effects of endogenous indole-3-acetic acid (IAA) onMedicagoplant growth and dry weight production, we increased the synthesis of IAA in both free-living and symbiosis-stage rhizobial bacteroids duringRhizobium-legume symbiosis. For this purpose, site-directed mutagenesis was applied to modify an 85-bp promoter sequence, driving the expression ofiaaMandtms2genes for IAA biosynthesis. A positive correlation was found between the higher expression of IAA biosynthetic genes in free-living bacteria and the increased production of IAA under both free-living and

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6

Moore, Thomas C. "Apparent endogenous circadian rhythm inent-kaurene biosynthesis." Journal of Plant Growth Regulation 9, no. 1-4 (1990): 185–87. http://dx.doi.org/10.1007/bf02041960.

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7

Anwar, Ali, Longqiang Bai, Li Miao, et al. "24-Epibrassinolide Ameliorates Endogenous Hormone Levels to Enhance Low-Temperature Stress Tolerance in Cucumber Seedlings." International Journal of Molecular Sciences 19, no. 9 (2018): 2497. http://dx.doi.org/10.3390/ijms19092497.

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Phytohormone biosynthesis and accumulation are essential for plant growth and development and stress responses. Here, we investigated the effects of 24-epibrassinolide (EBR) on physiological and biochemical mechanisms in cucumber leaves under low-temperature stress. The cucumber seedlings were exposed to treatments as follows: NT (normal temperature, 26 °C/18 °C day/night), and three low-temperature (12 °C/8 °C day/night) treatments: CK (low-temperature stress); EBR (low-temperature and 0.1 μM EBR); and BZR (low-temperature and 4 μM BZR, a specific EBR biosynthesis inhibitor). The results indi

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Nicktam, Thokchom, Chenu Sri Likhitha, Roshnee Nameirakpam, and Jatinder Singh. "Enhancement of Postharvest Life of Fruits by Application of Salicylic Acid." International Journal of Plant & Soil Science 35, no. 10 (2023): 15–22. http://dx.doi.org/10.9734/ijpss/2023/v35i102919.

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Salicylic acid (SA), an endogenous plant growth regulator, has been found to produce a wide range of metabolic and physiological responses in plants thereby affecting their growth and development. SA as a natural and safe phenolic compound, which exhibits a high potential in controlling postharvest losses of fruit crops. In this review, various intrinsic biosynthetic pathways and effects of exogenous salicylic acid on respiration, antioxidant systems, ethylene biosynthesis action, oxidative stress, nutritional quality, firmness, disease resistance and postharvest decay have also been discussed

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Parada, Francisca, Jana Oklestkova, and Patricio Arce-Johnson. "Characterization of Endogenous Levels of Brassinosteroids and Related Genes in Grapevines." International Journal of Molecular Sciences 23, no. 3 (2022): 1827. http://dx.doi.org/10.3390/ijms23031827.

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Agronomic breeding practices for grapevines (Vitis vinifera L.) include the application of growth regulators in the field. Brassinosteroids (BRs) are a family of sterol-derived plant hormones that regulate several physiological processes and responses to biotic and abiotic stress. In grapevine berries, the production of biologically active BRs, castasterone and 6-deoxocastasterone, has been reported. In this work, key BR genes were identified, and their expression profiles were determined in grapevine. Bioinformatic homology analyses of the Arabidopsis genome found 14 genes associated with bio

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10

Li, Mengfan, Justyna Wrobel-Marek, Iris Heidmann, et al. "Auxin biosynthesis maintains embryo identity and growth during BABY BOOM-induced somatic embryogenesis." Plant Physiology 188, no. 2 (2021): 1095–110. http://dx.doi.org/10.1093/plphys/kiab558.

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Abstract Somatic embryogenesis is a type of plant cell totipotency where embryos develop from nonreproductive (vegetative) cells without fertilization. Somatic embryogenesis can be induced in vitro by auxins, and by ectopic expression of embryo-expressed transcription factors like the BABY BOOM (BBM) AINTEGUMENTA-LIKE APETALA2/ETHYLENE RESPONSE FACTOR domain protein. These different pathways are thought to converge to promote auxin response and biosynthesis, but the specific roles of the endogenous auxin pathway in somatic embryogenesis induction have not been well-characterized. Here we show

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Freel, E. M., M. Bernhardt, R. Ingram, et al. "Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy." Clinical Endocrinology 66, no. 5 (2007): 659–65. http://dx.doi.org/10.1111/j.1365-2265.2007.02791.x.

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Freel, E. M., M. Bernhardt, R. Ingram, et al. "Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy." Clinical Endocrinology 66, no. 6 (2007): 901. http://dx.doi.org/10.1111/j.1365-2265.2007.02893.x.

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LATEEF, A. BARI, and SHEIKH A. SAEED. "Endogenous inhibitor of prostaglandin biosynthesis in cerebrospinal fluid." Biochemical Society Transactions 17, no. 5 (1989): 877. http://dx.doi.org/10.1042/bst0170877.

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Ikram, Kashkooli, Peramuna, Krol, Bouwmeester, and Simonsen. "Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens." Molecules 24, no. 21 (2019): 3822. http://dx.doi.org/10.3390/molecules24213822.

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: Metabolic engineering is an integrated bioengineering approach, which has made considerable progress in producing terpenoids in plants and fermentable hosts. Here, the full biosynthetic pathway of artemisinin, originating from Artemisia annua, was integrated into the moss Physcomitrella patens. Different combinations of the five artemisinin biosynthesis genes were ectopically expressed in P. patens to study biosynthesis pathway activity, but also to ensure survival of successful transformants. Transformation of the first pathway gene, ADS, into P. patens resulted in the accumulation of the e

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Li, Yanran, Sijin Li, Kate Thodey, Isis Trenchard, Aaron Cravens, and Christina D. Smolke. "Complete biosynthesis of noscapine and halogenated alkaloids in yeast." Proceedings of the National Academy of Sciences 115, no. 17 (2018): E3922—E3931. http://dx.doi.org/10.1073/pnas.1721469115.

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Microbial biosynthesis of plant natural products from simple building blocks is a promising approach toward scalable production and modification of high-value compounds. The pathway for biosynthesis of noscapine, a potential anticancer compound, from canadine was recently elucidated as a 10-gene cluster from opium poppy. Here we demonstrate the de novo production of noscapine in Saccharomyces cerevisiae, through the reconstruction of a biosynthetic pathway comprising over 30 enzymes from plants, bacteria, mammals, and yeast itself, including 7 plant endoplasmic reticulum (ER)-localized enzymes

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Zhang, Mengxia, Bingrun Yang, Yanyan Wang, and Fang Yu. "CrJAT1 Regulates Endogenous JA Signaling for Modulating Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus." Genes 15, no. 3 (2024): 324. http://dx.doi.org/10.3390/genes15030324.

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Many monoterpenoid indole alkaloids (MIAs) produced in Catharanthus roseus have demonstrated biological activities and clinical potential. However, their complex biosynthesis pathway in plants leads to low accumulation, limiting therapeutic applications. Efforts to elucidate the MIA biosynthetic regulatory mechanism have focused on improving accumulation levels. Previous studies revealed that jasmonic acid (JA), an important plant hormone, effectively promotes MIA accumulation by inducing the expression of MIA biosynthesis and transport genes. Nevertheless, excessive JA signaling can strongly

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17

Ding, Qiangqiang, Feng Wang, Juan Xue, et al. "Identification and Expression Analysis of Hormone Biosynthetic and Metabolism Genes in the 2OGD Family for Identifying Genes That May Be Involved in Tomato Fruit Ripening." International Journal of Molecular Sciences 21, no. 15 (2020): 5344. http://dx.doi.org/10.3390/ijms21155344.

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Phytohormones play important roles in modulating tomato fruit development and ripening. The 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily containing several subfamilies involved in hormone biosynthesis and metabolism. In this study, we aimed to identify hormone biosynthesis and metabolism-related to 2OGD proteins in tomato and explored their roles in fruit development and ripening. We identified nine 2OGD protein subfamilies involved in hormone biosynthesis and metabolism, including the gibberellin (GA) biosynthetic protein families GA20ox and GA3ox, GA degradation protein families C

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Levitskiy, А. P., Yu A. Levitskiy, I. A. Selivanska, А. P. Lapinska та V. V. Velichko. "HIGH OLEIC SUNFLOWER OIL DECREASES ENDOGENOUS BIOSYNTHESIS OF ENERGY FATTY ACIDS AND INCREASES ENDOGENOUS BIOSYNTHESIS OF ω-3 LONG-CHAIN PUFA". Grain Products and Mixed Fodder’s 22, № 4 (2022): 36–40. http://dx.doi.org/10.15673/gpmf.v22i4.2574.

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The work shows that Fatty acids of dietary fats provide two main functions in the human and animal body: energy and structural-regulatory, Polyunsaturated fatty acids (PUFA) are the basis of membrane lipids of all cells of the body The structure and functional activity of cells, their resistance to pathogenic factors depends on the ratio of ω-6 / ω-3 PUFA. Аdherence to recommended metabolic energy reserves in poultry feed is essential to optimize feed costs. The use of oils or fats is a common economic practice in modern poultry production. Energy functions are carried out due to the oxidation

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Ashihara, Hiroshi, Hisayo Shimizu, Yoshiyuki Takeda, Takeo Suzuki, Fiona M. Gillies, and Alan Crozier. "Caffeine Metabolism in High and Low Caffeine Containing Cultivars of Camellia sinensis." Zeitschrift für Naturforschung C 50, no. 9-10 (1995): 602–7. http://dx.doi.org/10.1515/znc-1995-9-1002.

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Abstract The metabolism of [8-14C ]adenine and [2-14C]caffeine was examined in leaf segments from flush shoots of tea cultivars with high and low caffeine content. The caffeine biosynthesis pathway from AMP via theobromine was operative in both high and low caffeine containing cultivars. There was a m ore rapid rate of caffeine biosynthesis from [8-14C ]adenine in the high caffeine cultivars while the rate of degradation of both adenine nucleotides and caffeine into CO2 was greatest in cultivars with a low endogenous caffeine content. Cell-free p reparations from tea shoots contained an N-meth

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20

Hwang, Ok Jin, and Kyoungwhan Back. "Molecular Regulation of Antioxidant Melatonin Biosynthesis by Brassinosteroid Acting as an Endogenous Elicitor of Melatonin Induction in Rice Seedlings." Antioxidants 11, no. 5 (2022): 918. http://dx.doi.org/10.3390/antiox11050918.

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Gibberellic acid (GA) was recently shown to induce melatonin synthesis in rice. Here, we examined whether brassinosteroids (BRs) also induce melatonin synthesis because BRs and GA show redundancy in many functions. Among several plant hormones, exogenous BR treatment induced melatonin synthesis by twofold compared to control treatment, whereas ethylene, 6-benzylaminopurine (BA), and indole-3-acetic acid (IAA) showed negligible effects on melatonin synthesis. Correspondingly, BR treatment also induced a number of melatonin biosynthetic genes in conjunction with the suppression of melatonin cata

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VAZ, Frédéric M., and Ronald J. A. WANDERS. "Carnitine biosynthesis in mammals." Biochemical Journal 361, no. 3 (2002): 417–29. http://dx.doi.org/10.1042/bj3610417.

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Carnitine is indispensable for energy metabolism, since it enables activated fatty acids to enter the mitochondria, where they are broken down via β-oxidation. Carnitine is probably present in all animal species, and in numerous micro-organisms and plants. In mammals, carnitine homoeostasis is maintained by endogenous synthesis, absorption from dietary sources and efficient tubular reabsorption by the kidney. This review aims to cover the current knowledge of the enzymological, molecular, metabolic and regulatory aspects of mammalian carnitine biosynthesis, with an emphasis on the human and ra

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Liao, Xiong, Mengsi Li, Bin Liu, et al. "Interlinked regulatory loops of ABA catabolism and biosynthesis coordinate fruit growth and ripening in woodland strawberry." Proceedings of the National Academy of Sciences 115, no. 49 (2018): E11542—E11550. http://dx.doi.org/10.1073/pnas.1812575115.

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Fruit growth and ripening are controlled by multiple phytohormones. How these hormones coordinate and interact with each other to control these processes at the molecular level is unclear. We found in the early stages of Fragaria vesca (woodland strawberry) fruit development, auxin increases both widths and lengths of fruits, while gibberellin [gibberellic acid (GA)] mainly promotes their longitudinal elongation. Auxin promoted GA biosynthesis and signaling by activating GA biosynthetic and signaling genes, suggesting auxin function is partially dependent on GA function. To prevent the repress

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Strobbe, Simon, Jana Verstraete, Christophe Stove, and Dominique Van Der Straeten. "Metabolic engineering provides insight into the regulation of thiamin biosynthesis in plants." Plant Physiology 186, no. 4 (2021): 1832–47. http://dx.doi.org/10.1093/plphys/kiab198.

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Abstract Thiamin (or thiamine) is a water-soluble B-vitamin (B1), which is required, in the form of thiamin pyrophosphate, as an essential cofactor in crucial carbon metabolism reactions in all forms of life. To ensure adequate metabolic functioning, humans rely on a sufficient dietary supply of thiamin. Increasing thiamin levels in plants via metabolic engineering is a powerful strategy to alleviate vitamin B1 malnutrition and thus improve global human health. These engineering strategies rely on comprehensive knowledge of plant thiamin metabolism and its regulation. Here, multiple metabolic

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SERHAN, CHARLES N, TOMOKO TAKANO, NAN CHIANG, KARSTEN GRONERT, and CLARY B CLISH. "Formation of Endogenous “Antiinflammatory” Lipid Mediators by Transcellular Biosynthesis." American Journal of Respiratory and Critical Care Medicine 161, supplement_1 (2000): S95—S101. http://dx.doi.org/10.1164/ajrccm.161.supplement_1.ltta-19.

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Kvetnoi, I. M., I. P. Kololyuk, and G. M. Deineko. "Immunohistochemical identification of endogenous sources of cardiac glycoside biosynthesis." Bulletin of Experimental Biology and Medicine 101, no. 4 (1986): 405–6. http://dx.doi.org/10.1007/bf00834393.

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Yamaguchi, S., and Y. Kamiya. "Gibberellin Biosynthesis: Its Regulation by Endogenous and Environmental Signals." Plant and Cell Physiology 41, no. 3 (2000): 251–57. http://dx.doi.org/10.1093/pcp/41.3.251.

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Chen, Mingjie, Li Guo, Huiwen Zhou, et al. "Absolute Quantitative Volatile Measurement from Fresh Tea Leaves and the Derived Teas Revealed Contributions of Postharvest Synthesis of Endogenous Volatiles for the Aroma Quality of Made Teas." Applied Sciences 11, no. 2 (2021): 613. http://dx.doi.org/10.3390/app11020613.

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Characteristic aroma is a well-appreciated feature contributing to tea quality. Although extensive studies have been made to investigate aroma biosynthesis and gene expressions during tea making processes, it remains unclear whether the endogenous volatile biosynthesis during postharvest tea processing contributes to the aroma quality of made tea. To critically evaluate this question, we used the same batch of fresh tea leaves and produced three different types of tea with different degrees of fermentation (green tea, oolong tea, and black tea). Total volatiles were extracted by solvent-assist

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Chen, Mingjie, Li Guo, Huiwen Zhou, et al. "Absolute Quantitative Volatile Measurement from Fresh Tea Leaves and the Derived Teas Revealed Contributions of Postharvest Synthesis of Endogenous Volatiles for the Aroma Quality of Made Teas." Applied Sciences 11, no. 2 (2021): 613. http://dx.doi.org/10.3390/app11020613.

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Characteristic aroma is a well-appreciated feature contributing to tea quality. Although extensive studies have been made to investigate aroma biosynthesis and gene expressions during tea making processes, it remains unclear whether the endogenous volatile biosynthesis during postharvest tea processing contributes to the aroma quality of made tea. To critically evaluate this question, we used the same batch of fresh tea leaves and produced three different types of tea with different degrees of fermentation (green tea, oolong tea, and black tea). Total volatiles were extracted by solvent-assist

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Rizopoulos, Zaira, Kai Matuschewski, and Joana M. Haussig. "Distinct Prominent Roles for Enzymes of Plasmodium berghei Heme Biosynthesis in Sporozoite and Liver Stage Maturation." Infection and Immunity 84, no. 11 (2016): 3252–62. http://dx.doi.org/10.1128/iai.00148-16.

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Malarial parasites have evolved complex regulation of heme supply and disposal to adjust to heme-rich and -deprived host environments. In addition to its own pathway for heme biosynthesis,Plasmodiumlikely harbors mechanisms for heme scavenging from host erythrocytes. Elaborate compartmentalization ofde novoheme synthesis into three subcellular locations, including the vestigial plastid organelle, indicates critical roles in life cycle progression. In this study, we systematically profile the essentiality of heme biosynthesis by targeted gene deletion of enzymes in early steps of this pathway.

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Yokoi, Takeru, Keisuke Isobe, Tohru Yoshimura, and Hisashi Hemmi. "Archaeal Phospholipid Biosynthetic Pathway Reconstructed inEscherichia coli." Archaea 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/438931.

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A part of the biosynthetic pathway of archaeal membrane lipids, comprised of 4 archaeal enzymes, was reconstructed in the cells ofEscherichia coli. The genes of the enzymes were cloned from a mesophilic methanogen,Methanosarcina acetivorans, and the activity of each enzyme was confirmed using recombinant proteins.In vitroradioassay showed that the 4 enzymes are sufficient to synthesize an intermediate of archaeal membrane lipid biosynthesis, that is, 2,3-di-O-geranylgeranyl-sn-glycerol-1-phosphate, from precursors that can be produced endogenously inE. coli. Introduction of the 4 genes intoE.

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Tew, Simon R., Peraphan Pothacharoen, Theoni Katopodi, and Timothy E. Hardingham. "SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription." Biochemical Journal 414, no. 2 (2008): 231–36. http://dx.doi.org/10.1042/bj20080262.

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The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the characteristic GAG (glycosaminoglycan)-rich ECM (extracellular matrix) of cartilage. SOX9 expression rapidly falls during monolayer culture of isolated chondrocytes and this turns off aggrecan and associated CS synthesis. We therefore investigated whether SOX9 transduction of cultured human articular c

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Hafiz, Fatema Binte, Joerg Geistlinger, Abdullah Al Mamun, Ingo Schellenberg, Günter Neumann, and Wilfried Rozhon. "Tissue-Specific Hormone Signalling and Defence Gene Induction in an In Vitro Assembly of the Rapeseed Verticillium Pathosystem." International Journal of Molecular Sciences 24, no. 13 (2023): 10489. http://dx.doi.org/10.3390/ijms241310489.

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Priming plants with beneficial microbes can establish rapid and robust resistance against numerous pathogens. Here, compelling evidence is provided that the treatment of rapeseed plants with Trichoderma harzianum OMG16 and Bacillus velezensis FZB42 induces defence activation against Verticillium longisporum infection. The relative expressions of the JA biosynthesis genes LOX2 and OPR3, the ET biosynthesis genes ACS2 and ACO4 and the SA biosynthesis and signalling genes ICS1 and PR1 were analysed separately in leaf, stem and root tissues using qRT-PCR. To successfully colonize rapeseed roots, t

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Hmidene, Asma Ben, Hiroshi Ono, and Shigemi Seo. "Phytosterols Are Involved in Sclareol-Induced Chlorophyll Reductions in Arabidopsis." Plants 12, no. 6 (2023): 1282. http://dx.doi.org/10.3390/plants12061282.

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Sclareol, a diterpene, has a wide range of physiological effects on plants, such as antimicrobial activity; disease resistance against pathogens; and the expression of genes encoding proteins involved in metabolism, transport, and phytohormone biosynthesis and signaling. Exogenous sclareol reduces the content of chlorophyll in Arabidopsis leaves. However, the endogenous compounds responsible for sclareol-induced chlorophyll reduction remain unknown. The phytosterols campesterol and stigmasterol were identified as compounds that reduce the content of chlorophyll in sclareol-treated Arabidopsis

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Wang, Dongmei, Yuxiang Cao, Meiyao Meng, et al. "FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma." PLOS Biology 22, no. 5 (2024): e3002621. http://dx.doi.org/10.1371/journal.pbio.3002621.

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Cholesterol metabolism is vital for multiple cancer progression, while how cholesterol affects lung, a low-cholesterol tissue, for cancer metastasis and the underlying mechanism remain unclear. In this study, we found that metastatic lung adenocarcinoma cells acquire cellular dehydrocholesterol and cholesterol by endogenous cholesterol biosynthesis, instead of uptake upon cholesterol treatment. Besides, we demonstrated that exogenous cholesterol functions as signaling molecule to induce FOXA3, a key transcription factor for lipid metabolism via GLI2. Subsequently, ChIP-seq analysis and molecul

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Bannenberg, Gerard L., Julio Aliberti, Song Hong, Alan Sher, and Charles Serhan. "Exogenous Pathogen and Plant 15-Lipoxygenase Initiate Endogenous Lipoxin A4 Biosynthesis." Journal of Experimental Medicine 199, no. 4 (2004): 515–23. http://dx.doi.org/10.1084/jem.20031325.

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Lipoxin A4 (LXA4) is a potent endogenous lipoxygenase-derived eicosanoid with antiinflammatory and proresolving properties. Supraphysiological levels of LXA4 are generated during infection by Toxoplasma gondii, which in turn reduces interleukin (IL) 12 production by dendritic cells, thus dampening Th1-type cell-mediated immune responses and host immunopathology. In the present work, we sought evidence for the structural basis of T. gondii's ability to activate LXA4 biosynthesis. Proteomic analysis of T. gondii extract (soluble tachyzoite antigen [STAg]), which preserves the immunosuppressive a

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Mao, Yuye, Jiajia Luo, and Zeping Cai. "Biosynthesis and Regulatory Mechanisms of Plant Flavonoids: A Review." Plants 14, no. 12 (2025): 1847. https://doi.org/10.3390/plants14121847.

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Flavonoids are a class of secondary metabolites synthesized by plants, characterized by a C6-C3-C6 carbon skeleton and derived from the phenylpropane metabolism pathway. They play crucial biological roles, not only in plant pigment production and responses to biotic and abiotic stresses but also in medicinal applications. Consequently, the biosynthesis and regulatory mechanisms of flavonoids have been a focal point in plant transcription and gene expression research. The biosynthetic pathways of flavonoids include branches such as isoflavones, flavones, flavonols, anthocyanins, and proanthocya

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Almannai, Mohammed, Majid Alfadhel, and Ayman W. El-Hattab. "Carnitine Inborn Errors of Metabolism." Molecules 24, no. 18 (2019): 3251. http://dx.doi.org/10.3390/molecules24183251.

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Carnitine plays essential roles in intermediary metabolism. In non-vegetarians, most of carnitine sources (~75%) are obtained from diet whereas endogenous synthesis accounts for around 25%. Renal carnitine reabsorption along with dietary intake and endogenous production maintain carnitine homeostasis. The precursors for carnitine biosynthesis are lysine and methionine. The biosynthetic pathway involves four enzymes: 6-N-trimethyllysine dioxygenase (TMLD), 3-hydroxy-6-N-trimethyllysine aldolase (HTMLA), 4-N-trimethylaminobutyraldehyde dehydrogenase (TMABADH), and γ-butyrobetaine dioxygenase (BB

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Janas, Krystyna M., and Jiři Šebánek. "Effect of cotyledons and epicotyl upon the activity of endogenous gibberellins in roots of flax (Linum usitatissimum L.) seedlings." Acta Agrobotanica 34, no. 2 (2013): 231–33. http://dx.doi.org/10.5586/aa.1981.017.

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In 11-day-old flax seedlings, the level of endogenous gibberellins in roots decreased within 12 hours after the excision of cotyledons and the epicotyl; however, 24 to 48 hours after excision the gibberellin level increased again. The decrease in the gibberellin level within the first 12 hours after excision suggests a participation of the cotyledons and the epicotyl in the biosynthesis of endogenous gibberellins.

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Xie, Yuan Hong, Hong Yan Gao, Yun Bo Luo, Hong Xing Zhang, Xiang Ning Chen, and Ben Zhong Zhu. "Role of Ethylene in the Biosynthesis of Fatty Acid-Derived Volatiles in Tomato Fruits." Advanced Materials Research 343-344 (September 2011): 937–50. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.937.

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Regulation of ethylene biosynthesis or action has an important effect on volatiles production in tomato (Lycopersicon esculentum) fruits. To understand the role of ethylene in the biosynthesis of fatty acid-derived aroma volatiles in tomato, we used Lichun tomato from a transgenic line with strictly suppression of ethylene biosynthesis (antisenseLeACS2tomato) and its wild type background line. This study was focused on the levels of the precursor substrates, activities and transcriptional levels of aroma volatile-related enzymes, including lipoxygenase (LOX), hydroperoxide lyase (HPL) and alco

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Carneros, Elena, Jorge Sánchez-Muñoz, Yolanda Pérez-Pérez, Beatriz Pintos, Aránzazu Gómez-Garay, and Pilar S. Testillano. "Dynamics of Endogenous Auxin and Its Role in Somatic Embryogenesis Induction and Progression in Cork Oak." Plants 12, no. 7 (2023): 1542. http://dx.doi.org/10.3390/plants12071542.

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Somatic embryogenesis (SE) is a feasible in vitro regeneration system with biotechnological applications in breeding programs, although, in many forest species, SE is highly inefficient, mainly due to their recalcitrance. On the other hand, SE represents a valuable model system for studies on cell reprogramming, totipotency acquisition, and embryogenic development. The molecular mechanisms that govern the transition of plant somatic cells to embryogenic cells are largely unknown. There is increasing evidence that auxins mediate this transition and play a key role in somatic embryo development,

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Huang, Xin, Lucía Morote, Changfu Zhu, et al. "The Biosynthesis of Non-Endogenous Apocarotenoids in Transgenic Nicotiana glauca." Metabolites 12, no. 7 (2022): 575. http://dx.doi.org/10.3390/metabo12070575.

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Crocins are high-value compounds with industrial and food applications. Saffron is currently the main source of these soluble pigments, but its high market price hinders its use by sectors, such as pharmaceutics. Enzymes involved in the production of these compounds have been identified in saffron, Buddleja, and gardenia. In this study, the enzyme from Buddleja, BdCCD4.1, was constitutively expressed in Nicotiana glauca, a tobacco species with carotenoid-pigmented petals. The transgenic lines produced significant levels of crocins in their leaves and petals. However, the accumulation of crocin

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HAMLYN, JOHN M., JAMES LAREDO, JUI R. SHAH, ZHUO REN LU, and BRUCE P. HAMILTON. "11-Hydroxylation in the Biosynthesis of Endogenous Ouabain: Multiple Implications." Annals of the New York Academy of Sciences 986, no. 1 (2003): 685–93. http://dx.doi.org/10.1111/j.1749-6632.2003.tb07283.x.

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Guo, Lei, Yongsheng Xiao, and Yinsheng Wang. "Monomethylarsonous acid inhibited endogenous cholesterol biosynthesis in human skin fibroblasts." Toxicology and Applied Pharmacology 277, no. 1 (2014): 21–29. http://dx.doi.org/10.1016/j.taap.2014.02.020.

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Moore, P. K., R. Evans, and O. A. al-Swayeh. "Rabbit brain contains an endogenous inhibitor of nitric oxide biosynthesis." European Journal of Pharmacology 183, no. 2 (1990): 646–47. http://dx.doi.org/10.1016/0014-2999(90)93574-a.

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LEVYTSKY, Anatoly, Igor KHODAKOV, Vladyslav VELYCHKO, Iryna SELIVANSKA, and Alla LAPINSKA. "Endogenous biosynthesis of “essential” fatty acids in the animal organism." Fitoterapia, no. 2 (2023): 35–41. http://dx.doi.org/10.32782/2522-9680-2023-2-44.

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Kream, R. M., George B. Stefano, and R. Ptáček. "Psychiatric Implications of Endogenous Morphine: Up-To-Date Review." Folia Biologica 56, no. 6 (2010): 231–41. http://dx.doi.org/10.14712/fb2010056060231.

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For over 30 years empirical studies have repeatedly demonstrated that the biosynthesis of morphine by diverse animal and human tissues occurs. Recently, the blue mussel’s neural tissues and human white blood cells were used to demonstrate the de novo biosynthesis of morphine for small precursor molecules derived from the aromatic amino acid L-tyrosine. Because catecholamine precursors, i.e., L-3,4-dihydroxyphenylalanine (L-DOPA), were also found to be utilized as morphine precursors, a novel reciprocally interactive mechanism is apparent that links catecholamine and opioid pathways in the acti

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Wang, Tao, Zheng Song, Xiaojing Wang, Lijun Xu, Qiwu Sun, and Lubin Li. "Functional Insights into the Roles of Hormones in the Dendrobium officinale-Tulasnella sp. Germinated Seed Symbiotic Association." International Journal of Molecular Sciences 19, no. 11 (2018): 3484. http://dx.doi.org/10.3390/ijms19113484.

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Dendrobium is one of the largest genera in the Orchidaceae, and D. officinale is used in traditional medicine, particularly in China. D. officinale seeds are minute and contain limited energy reserves, and colonization by a compatible fungus is essential for germination under natural conditions. When the orchid mycorrhizal fungi (OMF) initiates symbiotic interactions with germination-driven orchid seeds, phytohormones from the orchid or the fungus play key roles, but the details of the possible biochemical pathways are still poorly understood. In the present study, we established a symbiotic s

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Zhang, Ru, Shiquan Tan, Bianling Zhang, Pengcheng Hu, and Ling Li. "Cerium-Promoted Ginsenosides Accumulation by Regulating Endogenous Methyl Jasmonate Biosynthesis in Hairy Roots of Panax ginseng." Molecules 26, no. 18 (2021): 5623. http://dx.doi.org/10.3390/molecules26185623.

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Among rare earth elements, cerium has the unique ability of regulating the growth of plant cells and the biosynthesis of metabolites at different stages of plant development. The signal pathways of Ce3+-mediated ginsenosides biosynthesis in ginseng hairy roots were investigated. At a low concentration, Ce3+ improved the elongation and biomass of hairy roots. The Ce3+-induced accumulation of ginsenosides showed a high correlation with the reactive oxygen species (ROS), as well as the biosynthesis of endogenous methyl jasmonate (MeJA) and ginsenoside key enzyme genes (PgSS, PgSE and PgDDS). At a

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Zhao, Minglei, Caiqin Li, Xingshuai Ma, et al. "KNOX protein KNAT1 regulates fruitlet abscission in litchi by repressing ethylene biosynthetic genes." Journal of Experimental Botany 71, no. 14 (2020): 4069–82. http://dx.doi.org/10.1093/jxb/eraa162.

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Abstract Abscission is triggered by multiple environmental and developmental cues, including endogenous plant hormones. KNOTTED-LIKE HOMEOBOX (KNOX) transcription factors (TFs) play an important role in controlling abscission in plants. However, the underlying molecular mechanism of KNOX TFs in abscission is largely unknown. Here, we identified LcKNAT1, a KNOTTED-LIKE FROM ARABIDOPSIS THALIANA1 (KNAT1)-like protein from litchi, which regulates abscission by modulating ethylene biosynthesis. LcKNAT1 is expressed in the fruit abscission zone and its expression decreases during fruitlet abscissio

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Chalabaev, Sabina, Evelyne Turlin, Sylvie Bay, et al. "Cinnamic Acid, an Autoinducer of Its Own Biosynthesis, Is Processed via Hca Enzymes in Photorhabdus luminescens." Applied and Environmental Microbiology 74, no. 6 (2008): 1717–25. http://dx.doi.org/10.1128/aem.02589-07.

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ABSTRACT Photorhabdus luminescens, an entomopathogenic bacterium and nematode symbiont, has homologues of the Hca and Mhp enzymes. In Escherichia coli, these enzymes catalyze the degradation of the aromatic compounds 3-phenylpropionate (3PP) and cinnamic acid (CA) and allow the use of 3PP as sole carbon source. P. luminescens is not able to use 3PP and CA as sole carbon sources but can degrade them. Hca dioxygenase is involved in this degradation pathway. P. luminescens synthesizes CA from phenylalanine via a phenylalanine ammonia-lyase (PAL) and degrades it via the not-yet-characterized biosy

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