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Journal articles on the topic 'Endogenous intoxication indices'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Lishnevska, Anastasiia, Mykola Chemych, Oksana Chemych, and Igor Chernetsky. "Immunoreactivity and intoxication syndrome in patients with chronic viral hepatitis c." Bangladesh Journal of Medical Science 22, no. 3 (2023): 508–14. http://dx.doi.org/10.3329/bjms.v22i3.65314.

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Method: Etiological, gender, age and laboratory characteristics of chronic viral hepatitis C (СVHC) were studied and analyzed. The distribution of patients depending on the virus genotype, the activity degree and the severity of liver fibrosis were found out. Indices of non-specific reactivity, endogenous intoxication and inflammation in the course of СVHC, their dependence on treatment were studied. Correlations between the values of non-specific reactivity, endogenous intoxication, inflammation and patients’ affiliation to the group of injecting drug users, the APRI score, the stage of liver

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2

Prokofieva, T. V., O. S. Polunina, E. A. Polunina, I. V. Sevostyanova, and P. N. Voronina. "Assessment of endogenous intoxication based on the study of medium and low molecular weight substances in patients with myocardial infarction against a background of chronic obstructive pulmonary disease." Meditsinskiy sovet = Medical Council, no. 17 (October 15, 2022): 106–15. http://dx.doi.org/10.21518/2079-701x-2022-16-17-106-115.

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Introduction. Frequent comorbidity of chronic obstructive pulmonary disease and myocardial infarction is due to the commonality of a number of etiopathogenetic links and the development of endogenous intoxication syndrome. The convincing markers of endogenous intoxication syndrome are medium and low molecular weight molecules including medium and low molecular weight substances and oligopeptides.Aim. To study the levels of medium and low molecular weight substances in patients with myocardial infarction against the background of chronic obstructive pulmonary disease.Materials and methods. 225

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3

Svitailo, V. S., and M. D. Chemych. "INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, INFLAMMATORY ACTIVITY, AND SPECIFIC REACTIVITY IN PATIENTS WITH COVID-19." Інфекційні хвороби, no. 3 (October 11, 2024): 21–27. http://dx.doi.org/10.11603/1681-2727.2024.3.14873.

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The aim of the study is to identify changes in blood laboratory parameters, integrative indicators of endogenous intoxication, inflammation, and specific reactivity in patients with coronavirus disease. Patients and methods. The study included 77 patients with COVID-19, taking into account the inclusion and exclusion criteria. The comparison group consisted of 68 practically healthy people of the corresponding age. Laboratory blood tests were performed, on the basis of which integrative indicators of endogenous intoxication, inflammation and specific reactivity were calculated. Results. The da

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4

Karlova, O. O., O. V. Kuzminska, T. I. Trunina, and V. V. Melnyk. "The endogenous intoxication in workers exposed to lead." Likarska sprava, no. 5-6 (September 30, 2017): 162–67. http://dx.doi.org/10.31640/ls-2017(5-6)29.

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The calculated indices such as leukocytic (LI), hematological (HI) and nuclear (NI) became the most commonly used in clinical practice to determine the endogenous intoxication. The aim of this study was to determine informativeness of the calculation methods for verification of the endogenous intoxication in workers depending on the content of lead in their blood. The calculated indices (nuclear, hematological and leukocyte) have been carried out in the blood of 146 workers exposure to lead, whose concentration in the air of the working area exceeded the maximum permissible concentration 1.4–1

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5

Dzhyvak, V. H., O. I. Khlibovska, and I. M. Klishch. "ROLE OF ENDOGENIC INTOXICATION IN MUSCLE INJURY IN EXPERIMENT." International Journal of Medicine and Medical Research 5, no. 2 (2020): 122–27. http://dx.doi.org/10.11603/ijmmr.2413-6077.2019.2.10310.

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Background. Endogenous intoxication is a multicomponent complex process due to the endogenous biological products or dysfunction of systemic natural detoxification.  Objective. The aim of the research was to study the dynamics of indices of endogenous intoxication in rats with traumatic muscle damage in the experiment. Methods. The experiment was performed on 45 non-linear white rats, which were modeled with traumatic muscle damage. The level of endogenous intoxication was assessed by the content of medium plasma molecules (MMM), leukocyte and erythrocytic index of intoxication (LI

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6

Radchenko, O. M., O. V. Fedyk, and R. R. Guta. "HEMATOLOGICAL INDIXES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANEMIA." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 3 (2019): 71–74. http://dx.doi.org/10.31718/2077-1096.19.3.71.

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A retrospective analysis of 470 patients with chronic obstructive pulmonary disease and anemia was conducted in order to determine hematological indices. 17 markers of inflammation activity, endogenous intoxication, adaptation, nonspecific and immune reactivity were calculated during this analysis. It was established that the course of chronic obstructive pulmonary disease with anemia was accompanied by a more pronounced inflammation syndrome with a significant increase in stab and segmented neutrophilic granulocytes, an acceleration of the erythrocyte sedimentation rate, and significantly hig

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7

P. S. Nazar, M. M. Levon, O. I. Osadcha, and O. O. Shevchenko. "Dynamics of changes in the indices of the level of endogenous intoxication in patients with alcoholic lesions of the liver." Bukovinian Medical Herald 17, no. 1 (65) (2013): 68–70. http://dx.doi.org/10.24061/2413-0737.xvii.1.65.2013.17.

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Changes of the indices of the level of endogenous intoxication in 122 patients with an alcoholic lesion of the liver have been studied. It has been established that a high level of endogenous intoxication is identified in these patients connected with a reduction of the concentration of endogenous albumin in the peripheral blood, due to an accumulation of molecules of medium mass, a decrease of the effective concentration of albumin and the toxin-binding ability of albumin.

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8

Partsei, Khrystyna, Hanna Ersteniuk, Bohdana Valishkevych, and Halyna Tokaryk. "Erythrocyte indices under conditions of energy drink consumption in Ukraine." Tanzania Journal of Health Research 25, no. 3 (2024): 1150–62. https://doi.org/10.4314/thrb.v25i3.13.

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Background: The consumption of energy drinks, especially among young people, is constantly growing worldwide despite warnings about their safety. Therefore, determining the consequences of their impact on the human body and well-being is an actual issue. This work aimed to study the state of endogenous intoxication and the antioxidant system of erythrocytes in experimental animals that consumed energy drinks. Methods: The study was conducted on rats that consumed energy drinks for a month. Samples for analysis were taken on the 10th day after the end of the experiment. The biochemical methods

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9

Boev, I. A., A. P. Godovalov, G. I. Shtraube, and G. I. Antakov. "Characteristic features of maxillofacial phlegmon morbidity with assessment of efficiency of detoxication therapy." Perm Medical Journal 36, no. 2 (2019): 29–35. http://dx.doi.org/10.17816/pmj36229-35.

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Aim. To study the characteristic features of long-term facial phlegmon morbidity in Perm Krai with assessment of the efficiency of infusion therapy using indices of endogenous intoxication expression. Materials and methods. Manifestations of epidemic process of facial phlegmons were studied on the basis of a detailed retrospective analysis of sickness rate among the inhabitants of Perm Krai for the period of 2011–2016. In group 1, all patients besides standard therapy, underwent infusion therapy, and in group 2 – standard therapy alone. Prior to and after the therapy, peripheral blood ce

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10

Chemych, Oksana M., Mykola D. Chemych, Anna A. Olefir, and Oleh B. Berest. "CLINICAL FEATURES OF THE HIV INFECTION COURSE AND THE DEPENDENCE OF CHANGES IN LABORATORY PARAMETERS ON THE CLINICAL STAGE AND ON THE CD4 LYMPHOCYTES LEVEL." Wiadomości Lekarskie 74, no. 5 (2021): 1189–95. http://dx.doi.org/10.36740/wlek202105126.

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The aim: Is to determine the features of the HIV infection and changes in indicators of endogenous intoxication and immunoreactivity depending on the clinical stage and the level of CD4 lymphocytes. Materials and methods: 72 HIV-patients were examined. Comparison group included 40 healthy blood donors. Clinical and laboratory examination was performed. Indicators of endogenous intoxication, nonspecific reactivity and inflammatory activity were calculated. Results:Main opportunistic infections were: oropharyngeal candidiasis; tuberculosis of different localization, more often pulmonary tubercul

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11

Syrota, B. V. "Immuno-hematological indices of endogenous intoxication and cellular reactivity at acute intoxication diarrheal escherichiosis." Bukovinian Medical Herald 23, no. 1 (89) (2019): 74–80. http://dx.doi.org/10.24061/2413-0737.xxiii.1.89.2019.11.

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12

PROKOFYEVA, TATIANA V., OLGA S. POLUNINA, and EKATERINA A. POLUNINA. "PROGNOSIS OF SIGNIFICANT ISCHEMIC EVENTS AND LETHAL OUTCOME IN PATIENTS WITH MYOCARDIAL INFARCTION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE." Bulletin of Contemporary Clinical Medicine 16, no. 2 (2023): 49–55. http://dx.doi.org/10.20969/vskm.2023.16(2).49-55.

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Introduction. Myocardial infarction remains significant due to its high prevalence and disability. Of particular importance is the prediction of the risk of adverse events in myocardial infarction patients with cardiorespiratory comorbidity, in particular with chronic obstructive pulmonary disease. It can be assumed that endogenous intoxication syndrome can be considered as a predictor of life-threatening events (repeated myocardial infarction, stroke) and lethal outcome in patients with myocardial infarction against chronic obstructive pulmonary disease. Aim. The aim is to determine the proba

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13

Konovchuk, Viktor M., Sergiy V. Kushnir, Andriy V. Andrushchak, Iryna I. Iliuk, and Petro V. Moroz. "THE CONDITION OF VOLUMETRIC AND OSMOREGULATORY FUNCTION OF THE KIDNEYS IN TOXICEMIA OF PURULENT-SEPTIC GENESIS IN PATIENTS WITH DIABETES MELLITUS." Wiadomości Lekarskie 73, no. 4 (2020): 733–36. http://dx.doi.org/10.36740/wlek202004120.

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The aim of the study is to investigate the state of volumetric and osmoregulatory function of the kidneys in diabetes complicated by the syndrome of the endogenous intoxication of purulent-septic genesis. Materials and methods: The study group was consisted of patients with insulin-dependent diabetes mellitus with complicated syndrome of the endogenous intoxication of purulent-septic genesis (CSDI). Results: The starting indices of volumetric and osmoregulatory function of the kidneys in patients with INCs complicated by the endogenous intoxication of purulent-septic genesis (CEI GHG) syndrome

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14

Krutikova, M., B. Cholah, V. Fedoseeva, A. Khrenov, N. Naumova, and A. Katsev. "PROTEINURIA AND ENDOGENOUS INTOXICATION IN PATIENTS WITH LIVER CIRRHOSIS." Tavricheskiy Mediko-Biologicheskiy Vestnik 23, no. 3 (2022): 61–66. http://dx.doi.org/10.29039/2070-8092-2020-23-3-61-66.

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In patients with liver cirrhosis, structural changes develop in the renal parenchyma, accompanied by a violation of the total renal function. These processes lead to the aggravation of endogenous intoxication and to the progression of the underlying disease. The aim of the study was to define the relationship between proteinuria and urine albumin/creatinine ratio with indicators of endogenous intoxication in patients with liver cirrhosis. 146 patients with liver cirrhosis with various etiologies were examined. In all patients, the presence of proteinuria, middle molecules level, creatini

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15

Ходус, Сергей, Sergey Hodus, Константин Пустовит, Konstantin Pustovit, Сергей Аникин, and Sergey Anikin. "METHOD FOR ASSESSING OF SEVERITY OF SYMPTOMS OF THE ENDOGENOUS INTOXICATION SYNDROME AND ASSOCIATED RESPIRATORY DISORDERS IN PATIENTS WITH COLORECTAL CANCER." Bulletin physiology and pathology of respiration 1, no. 69 (2018): 82–87. http://dx.doi.org/10.12737/article_5b985459376cf6.40782134.

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The purpose of the research is to develop a method for assessing the severity of symptoms of the endogenous intoxication syndrome and associated respiratory disorders in patients with colorectal cancer. The study involved 86 patients (the main group included 51 patients with colorectal cancer, the control group 35 relatively healthy people). All patients were studied upon indicators of clinical blood test, and hematological indices of intoxication were calculated. In the patients of the main group, an assessment of the oxygen status parameters was done. The study revealed that 52.9% of patient

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16

Korobko, Y. Ye, V. S. Konoplitskyi, and O. O. Olkhomiak. "The value of a comprehensive assessment of the integrated indicator of endogenous intoxication of the organism and ultrasound imaging in the diagnostic process of the acute appendicitis in childhood." Paediatric Surgery. Ukraine, no. 4(73) (December 30, 2021): 59–65. http://dx.doi.org/10.15574/ps.2021.73.59.

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Traditionally, in the diagnosis of acute appendicitis and endogenous intoxication that accompanies its course, hemogram indicators and a wide range of proposed hematological indices are widely used. However, as practice shows, the isolated study of the hemogram, even with the involvement of its integral indices, especially in the early stages of pathology, is not enough for its timely diagnosis, and even more so the differential diagnosis. An important additional method of diagnosing acute appendicitis is ultrasound. Purpose – on the basis of specific clinical observation in the dynamics of th

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17

Dei, A. A., B. I. Geltser, M. V. Antonyuk, T. A. Gvozdenko, E. P. Kalinina, and I. N. Titorenco. "Assessing the relationship of respiratory muscle strength and cytokine status in patients with community-acquired pneumonia." PULMONOLOGIYA 31, no. 3 (2021): 311–19. http://dx.doi.org/10.18093/0869-0189-2021-31-3-311-319.

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Aim. Assessment of the role of cytokine-mediated changes in the development of respiratory muscle (RM) dysfunction in patients with community-acquired pneumonia (СAP). Methods. 84 men aged 18 – 26 years with a median of age 19.5 [18.4; 22.8]. Mild to moderate CAP (MCAP) was diagnosed in 62 (73.8%) patients and severe (SCAP) in 22 (26.2%). The expiratory (MEP, MRPDout) and inspiratory (MIP, MRPDin. SNIP) strength indices of RM were recorded on a MicrоRPM apparatus (CareFusion, UK). The severity of endogenous intoxication was verified using the following indices: hematologic (HII), leukocyte (LI

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18

Vlasov, A. P., D. Y. Timoshkin, M. A. Spirina, I. A. Chigakova, T. I. Vlasova, and T. A. Muratova. "LASER THERAPY FOR MANAGEMENT OF CEREBRAL DYSFUNCTION IN CASES OF ACUTE SEVERE PANCREATITIS." Russian Sklifosovsky Journal "Emergency Medical Care" 7, no. 2 (2018): 117–21. http://dx.doi.org/10.23934/2223-9022-2018-7-2-117-121.

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Background.A persistently high mortality rate of patients with pancreatitis is the result of multiple organ failure which is in many aspects associated with developing endogenous intoxication. Pancreatic encephalopathy is one of particular manifestations of this syndrome.Aim of study: to determine severity of cerebral dysfunction in cases of acute destructive pancreatitis, to assess the efficacy of laser therapy for this disease.Material and methods: The research is based on the results of clinical studies, carried out at the Republican Clinical Hospital No.3. Clinical laboratory analysis of 6

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19

Geltser, B. I., A. A. Dej, I. N. Titorenko, and V. N. Kotelnikov. "Comparative analysis of the strength of the respiratory muscles in community-acquired pneumonia with different severity of endogenous intoxication." Terapevticheskii arkhiv 92, no. 3 (2020): 19–24. http://dx.doi.org/10.26442/00403660.2020.03.000372.

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Aim. To assess the strength of the respiratory muscles in patients with community-acquired pneumonia (CAP) with varying severity of endogenous intoxication. Materials and methods. In the hospital, 78 men aged 1826 years with CAP were examined. СAP was diagnosed in 56 (72%) patients, severe CAP in 22 (28%). The severity of endogenous intoxication was verified using intoxication indices: hematological index of intoxication (HII), leukocyte index of intoxication (LII), nuclear index of intoxication (NII) and Krebs index. Middleweight molecules (MWM) was determined by spectrophotometry in th

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20

Bakhritdinova, F., K. Narzikulova, and S. Mirrakhimova. "Effect of photodynamic doses of laser irradiation on endogenous intoxication indices." Oftalmologicheskii Zhurnal 56, no. 4 (2015): 35–37. http://dx.doi.org/10.31288/oftalmolzh201543537.

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21

Chemych, Oksana, Mykola Chemych, Nina Malysh, Oleh Berest, Oleksandr Suprun, and Diana Svyrydenko. "Epidemiological and laboratory features of acute enteric infections." Bangladesh Journal of Medical Science 20, no. 4 (2021): 748–55. http://dx.doi.org/10.3329/bjms.v20i4.54129.

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Background: This work describes etiological structure and statistics for causes of acute enteric infections and salmonellosis in modern conditions. Method: It was analyzed the common epidemiologic signs and indices of modern acute enteric infections (AEI), caused by opportunistic microorganisms (OMO), various viruses and salmonella. Result: The research also shows the integrative intoxication indicators of causal groups in endogenous intoxication which point to these phenomena being caused by autointoxication at the moment of one’s own cells disruption as well as induced by bacteri

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Chemych, Mykola, Anastasiia Cherkashyna, and Oksana Chemych. "FEATURES OF CHANGES IN INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, REACTIVITY, INFLAMMATION ACTIVITY IN PATIENTS WITH CHRONIC VIRAL HEPATITIS AND CHRONIC RENAL FAILURE." Eastern Ukrainian Medical Journal 11, no. 4 (2023): 461–70. http://dx.doi.org/10.21272/eumj.2023;11(4):461-470.

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The aim: to study the peculiarities of changes in integrative indicators of endogenous intoxication, reactivity and activity of inflammation in patients with chronic viral hepatitis B and C, and with chronic renal failure undergoing hemodialysis. Materials and methods. 19 patients with chronic viral hepatitis B (HBV) and chronic viral hepatitis C (HCV) with chronic renal failure and patients with chronic kidney disease (KD) were examined. Comparison group included 40 healthy blood donors. Epidemiological, clinical and laboratory examination was performed. Indicators of endogenous intoxication,

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23

Saienko, Oleksandr, and Mykola Chemych. "CHANGES IN INDICATORS OF ENDOGENOUS INTOXICATION, NONSPECIFIC REACTIVITY, AND INFLAMMATION CAUSED BY SARS-COV-2." Eastern Ukrainian Medical Journal 12, no. 2 (2024): 422–30. http://dx.doi.org/10.21272/eumj.2024;12(2):422-430.

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Introduction: Despite the fact that the entire scientific world is concerned about COVID-19, about 65 million people are living with Long COVID, suffering from general weakness, fatigue, cognitive dysfunction, and shortness of breath. This problem is global for humanity because of the decrease in the ability to work and mental activity of the population, which leads to economic losses. The problem remains open and requires further research. Materials and Methods: a total of 108 patients were examined and divided into three groups: group A – 31 patients with confirmed COVID-19, group B – 35 pat

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Matviiuk, O. Ya. "DYNAMICS OF HEMATOLOGICAL PARAMETERS OF ENDOGENOUS INTOXICATION IN ADULT PATIENTS WITH MEASLES WITH DIFFERENT SEVERITY OF THE DISEASE." Bukovinian Medical Herald 28, no. 4 (112) (2024): 53–60. https://doi.org/10.24061/2413-0737.28.4.112.2024.9.

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Introduction. Measles is a highly contagious infectious disease with upper respiratory tract catarrh, conjunctivitis, stage exanthema and pronounced syndrome of endogenous intoxication.Aim. To determine the degree of endogenous intoxication syndrome in adult patients with measles and make a connection with the severity of the underlying disease.Materials and methods. There were observed 120 adult patients with measles. The diagnosis was confirmed by epidemiological, clinical and laboratory criteria, using the Android-application the integrative indicators of endogenous intoxication and immunor

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25

PROKOFYEVA, TATIANA V., OLGA A. BASHKINA, OLGA S. POLUNINA, LUDMILA P. VORONINA, IRINA V. SEVOSTYANOVA, and EKATERINA A. POLUNINA. "LEVELS OF MEDIUM- AND LOW-MOLECULAR-WEIGHT SUBSTANCES AND OLIGOPEPTIDES IN PATIENTS WITH MYOCARDIAL INFARCTION AGAINST CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH SINGLE- AND MULTIVESSEL CORONARY ARTERY DISEASE." Bulletin of Contemporary Clinical Medicine 15, no. 2 (2022): 49–59. http://dx.doi.org/10.20969/vskm.2022.15(2).49-59.

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Introduction. The presence of endogenous intoxication syndrome in somatic pathology worsens the course and prognosis of diseases. It is especially urgent to study this syndrome in comorbid pathology, in particular, in myocardial infarction development in patients with chronic obstructive pulmonary disease. The objective markers of endogenous intoxication are medium and low molecular weight substances and oligopeptides. Aim. The aim is to estimate the severity of endogenous intoxication syndrome by studying the levels of medium and low molecular weight substances and oligopeptides in patients w

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Prokofyeva, T. V., O. S. Polunina, L. P. Voronina, E. A. Polunina, and I. V. Sevostyanova. "Prognostic value of molecules of average mass in patients with chronic obstructive pulmonary disease." Acta Biomedica Scientifica 7, no. 6 (2022): 34–44. http://dx.doi.org/10.29413/abs.2022-7.6.4.

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Background. Chronic obstructive pulmonary disease is a socially significant disease affecting patient’s quality of life. Assessment of endogenous intoxication in patients with chronic obstructive pulmonary disease will allow to understand pathogenetic features of different phenotypes of this disease, which can be taken into account when predicting its course.The aim of the study. To determine the prognostic value of levels of mediumand low-molecular-weight substances and oligopeptides in patients with chronic obstructive pulmonary disease.Materials and methods. One hundred and four patients wi

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Sultanov, D. D., O. Nematzoda, A. Sh Shokhsavorbekov, R. K. Davlatov, H. A. Yunusov, and S. G. Ali-Zade. "Endogenous intoxication, oxidative stress and antioxidant system in acute lower limb ischemia." Health care of Tajikistan, no. 4 (February 18, 2023): 91–100. http://dx.doi.org/10.52888/0514-2515-2022-355-4-91-100.

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Aim. To study features of endogenous intoxication syndrome (EI), oxidative stress (LPO) and antioxidant defence (AOS) in patients with acute lower limb ischemia (LLI).Materials and methods. Some parameters of EI, LPO and AOS were studied. EI syndrome was studied in 86 patients with LLI who underwent complex examination and treatment in 2020-2021 in the Department of Vascular Surgery of the RNCfCS. POL and AOS parameters were studied in 14 patients out of 86. There were 51 (59.3%) men and 35 (40.7%) women, mean age was 56.0±5.8 years. Acute occlusion of the iliofemoral segments was noted in 33

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KRYNYTSKA, Inna, Mariya MARUSHCHAK, Liliya ODNORIH, and Iryna SAVCHENKO. "The indices of endogenous intoxication in rats with different models of hepatopulmonary syndrome." Archives of the Balkan Medical Union 54, no. 1 (2019): 38–44. http://dx.doi.org/10.31688/abmu.2019.54.1.05.

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Kalaeva, E. A., A. E. Chernitsky, V. N. Kalaev, and M. Alhamed. "Endogenous intoxication markers of deep-pregnant cows as predictors of pneumonia in newborn calves." Rossiiskaia selskokhoziaistvennaia nauka, no. 5 (October 23, 2019): 58–62. http://dx.doi.org/10.31857/s2500-26272019558-62.

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The aim of the work was to analyze the indices of endogenous intoxication in deep-pregnant cows and to identify the possibilities of their use as predictors of bronchopulmonary pathology in newborn calves. 29 cows were examined for 239-262 days of gestation and 29 newborn calves of the red-and-white Holstein breed. Bronchitis developed in all calves during the first month of life, and in 7 newborns it was complicated by pneumonia. Markers of endogenous intoxication of cows were analyzed: total and effective albumin concentration, serum MMP content, Kalf-Kalif leukocyte index of intoxication (L

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Sumtsova, Kateryna, Vladyslav Berezhok, Anastasiia Lishnevska, and Mykola Chemych. "THE DEPENDENCE OF CHANGES IN LABORATORY INDICATORS ON ACCOMPANYING PATHOLOGY IN PATIENTS WITH VIRAL HEPATITIS C." Eastern Ukrainian Medical Journal 12, no. 1 (2024): 69–80. http://dx.doi.org/10.21272/eumj.2024;12(1):69-80.

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Objective: to determine the dependence of changes in hematological, biochemical indicators and indexes of nonspecific reactivity, inflammation, endogenous intoxication on accompanying pathology in patients with chronic viral hepatitis C (HCV). Materials and methods: hematological, biochemical, non-specific immunological changes were analyzed in 20 chronic HCV patients without cardiovascular system pathologies, in 20 chronic HCV patients with concomitant coronary heart disease (CHD), in 20 people with coronary heart disease and arterial hypertension, and in 40 healthy people. Statistical analys

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Radzikhovskyi, M., V. Nedosekov, O. Dyshkant, I. Sokulsky, A. Antoniuk, and M. Rusinko. "Integrated indices as a criterion for evaluation of the level of endogenous intoxication for leptospirosis in dogs." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 23, no. 104 (2021): 77–83. http://dx.doi.org/10.32718/nvlvet10413.

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One of the most important directions in the development of modern veterinary medicine is the improvement and implementation of modern methods of diagnosis and prognosis of diseases based on determining the degree of dysfunction and the possibility of correcting the protective functions of the body. for most veterinary clinics, the study of the immunological status of animals is not available, and clinical blood tests make it possible to determine the assessment of the functional state of the immune system by integrated hematological parameters. In the article on the basis of blood formulas tha

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32

Pavliak, A. Ya, and O. V. Pyptiuk. "Endotoxicosis indices as means of prognosis in surgical sepsis caused by purulent-necrotic complications of sugar diabetes." Modern medical technologies 41 part 2, no. 2 (2019): 49–52. http://dx.doi.org/10.34287/mmt.2(41).2019.25.

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Purpose of the study. to study how the consequences of surgical sepsis caused by purulent-necrotic complications of sugar diabetes depend on the dynamics of endotoxicosis indices in the course of treatment. Material and methods. The research included 30 patients with the symptoms correlating with the criteria for surgical sepsis caused by purulentnecrotic complications of sugar diabetes. The patients had their level of endotoxicosis measured and the severity of their condition evaluated according to the scale. Results. 26 patients were discharged from hospital due to their recovery, 4 patients

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Цейко, З. А., Д. В. Терешков, Е. И. Козорез та И. О. Стома. "Эндогенная интоксикация у пациентов с хронической гепатит С вирусной инфекцией". Клиническая инфектология и паразитология 13, № 4 (2024): 526–35. https://doi.org/10.34883/pi.2024.13.4.038.

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Цель. Изучить показатели, характеризующие уровень эндогенной интоксикации, у госпитализированных пациентов с хронической гепатит С вирусной инфекцией. Материалы и методы. Проведен ретроспективный анализ клинико-лабораторных данных 222 госпитализированных пациентов с различными формами хронической гепатит С вирусной инфекции (хроническим гепатитом С и циррозом печени). В ходе исследования изучены показатели биохимического анализа крови, рассчитаны интегральные индексы для оценки эндогенной интоксикации. Результаты. Более чем у половины из всех исследуемых пациентов отмечено увеличение уровня пе

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Demkovych, Andrii. "Endogenous intoxication in development of experimental periodontitis of bacterial-immune genesis." Folia Medica 65, no. 1 (2023): 149–54. http://dx.doi.org/10.3897/folmed.65.e71970.

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Introduction: Excessive lipoperoxidation is accompanied by accumulation of peroxidation products and depletion of antioxidant re-serves, which cause hyperenzymemia and the accumulation of toxic substances. The level of endotoxicosis is determined by the content of hydrophilic and hydrophobic products in the blood.&nbsp; Aim: To define the pathogenetic role of endogenous intoxication in the dynamics of development of experimental periodontitis of bacterial-immune genesis.&nbsp; Materials and methods: The experiment was conducted on rats. The animals were divided into three groups: group

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Nerodo, G. A., I. A. Goroshinskaja, I. V. Neskubina, et al. "POSSIBILITIES OF THE CORRECTION OF ENDOGENOUS INTOXICATION DURING CHEMOTHERAPY IN GYNECOLOGICAL CANCER PATIENTS." Russian Journal of Oncology 22, no. 1 (2017): 25–31. http://dx.doi.org/10.18821/1028-9984-2017-22-1-25-31.

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Introduction. The application of efferent therapy (extracorporeal therapy) now becomes relevant due to the individual intolerance to various drugs, side effects of a great many of drugs, which is especially important when treating onco-gynecological pathology, often accompanied by the development of endogenous intoxication. The purpose of the study is the evaluation of the state of the system of endotoxemia in gynecological cancer patients under treatment by certain types of chemotherapy with the use of extracorporeal approaches. Material and Methods. In the blood of 86 ovarian cancer patients

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Shabunin, S. V., A. G. Nezhdanov, V. I. Mikhalev, E. G. Lozovaya, and A. E. Chernitskiy. "Prognostic value of endogenous intoxication and oxidative stress indices in early embryogenesis in cows." Russian Agricultural Sciences 42, no. 1 (2016): 101–4. http://dx.doi.org/10.3103/s1068367416010183.

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Lyubomyrska, K. S., V. G. Syusyuka, Yu Ya Krut, et al. "Non-invasive prognostic markers of the risk of preterm rupture of the membranes in premature pregnancy." Reproductive health of woman, no. 4 (August 17, 2022): 23–29. http://dx.doi.org/10.30841/2708-8731.4.2022.262763.

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The objective: to study the prognostic significance of non-invasive markers of endogenous intoxication for determining the risk of premature rupture of membranes (PROM) at the gestation period of 26–34 weeks.Materials and methods. During the study the patients were divided into two groups: the 1st (main) group – 80 women with PROM at 26–34 weeks of pregnancy, and the 2nd (control) group – 50 women with a physiological course of pregnancy and term delivery without complications. The mean age of the examined women was 29.60±6.30 years. To determine the diagnostic value of the level of hematologi

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K.S., Lyubomyrska, Syusyuka V.G., Krut Yu.Ya., et al. "NON-INVASIVE PROGNOSTIC MARKERS OF THE RISK OF PRETERM RUPTURE OF THE MEMBRANES IN PREMATURE PREGNANCY." Reproductive Health of Woman, no. 4 (June 30, 2022): 23–29. https://doi.org/10.30841/2708-8731.4.2022.262763.

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<em><strong>The objective:</strong> </em>to study the prognostic significance of non-invasive markers of endogenous intoxication for determining the risk of premature rupture of membranes (PROM) at the gestation period of 26–34 weeks. <em><strong>Materials and methods.</strong> </em>During the study the patients were divided into two groups: the 1st (main) group – 80 women with PROM at 26–34 weeks of pregnancy, and the 2nd (control) group – 50 women with a physiological course of pregnancy and term delivery without complications. The mean age of the examined w

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Vlasova, Natal'ya V., Elena R. Abdrakhmanova, Lyalya M. Masyagutova, Alina R. Muzafarova, and Linara A. Rafikova. "Occupational conditionality of integral hematological indices in metallurgical production workers." Russian Journal of Occupational Health and Industrial Ecology 64, no. 1 (2024): 42–49. http://dx.doi.org/10.31089/1026-9428-2024-64-1-42-49.

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The health of the working population is one of the main guarantors of the sustainable and planned development of the state's economy, while working conditions and factors of the production environment play an important role in its formation. Studies of indicators of endogenous intoxication make it possible to identify the formation of adaptive and compensatory changes in the hemogram depending on the conditions of the production environment and the labor  process. The study aims to explore the degree of professional conditionality of integral hematological indices for early diagnos

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Todoriko, L. D., Ya I. Toderika, O. S. Shevchenko, and M. G. Gingulyak. "Clinical and immunological characteristics of vitamin D level in drug-resistant tuberculosis." Infusion & Chemotherapy, no. 1 (March 23, 2025): 7–12. https://doi.org/10.32902/2663-0338-2025-1-7-12.

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BACKGROUND. To date, there are not enough studies that prove the relationship between a decrease in the level of vitamin D and the formation of resistance of mycobacterium tuberculosis. OBJECTIVE. Determination of vitamin D level in drug-resistant pulmonary tuberculosis and evaluation of its influence on the clinical course of the disease. MATERIALS AND METHODS. The randomized case-control study included 45 patients with newly diagnosed pulmonary tuberculosis with preserved sensitivity (group 1), 41 patients with multidrug-resistant tuberculosis (group 2) and 30 practically healthy individuals

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Radsikhovskii, M., L. Goralskii, B. Borissevich, and O. Dyshkant. "Integral indexes of intoxication in caninae coronaviridae enteritis." Naukovij vìsnik veterinarnoï medicini, no. 2 (144) (December 24, 2018): 13–19. http://dx.doi.org/10.33245/2310-4902-2018-144-2-13-19.

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In this article to be spoken about indicators of action of coronaviridae on an organism of animals – qualitative and quan-titative characteristics of blood. These indicators change at many patological reactions and participate in ensuring nonspe-cific and specific resistance of an organism. With the help of the analysis of integral leukocyte indices based on the formula of blood reflecting the state of neurohumoral homeostasis and immunological reactivity of the organism, the violations were first discovered and established humoral and cellular links of the immune system, micro- and macrophage

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Minin, Yuriy V., Julia G. Klys, Julia B. Burlaka, et al. "Indices of proteins’ and lipids’ peroxidation and the state of antioxidant system in patients with snoring." OTORHINOLARYNGOLOGY, no. 6(2) 2019 (March 30, 2020): 64–73. http://dx.doi.org/10.37219/2528-8253-2019-6-64.

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Aim: to investigate the intensity of proteins and lipids peroxidation, the state of the antioxidant system and biochemical indices of endogenous intoxication in patients with snoring. Materials and Methods: Blood serum of 20 patients with snoring and 19 healthy persons without any manifestation of respiratory complications at sleeping were studied. All patients were divided into two groups. Group I included 10 patients with moderate manifestation of snoring, and group II with the hard one. Results: An increase of the proteins’ oxidative modifications in patients with snoring without obstructiv

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Ефремов, А. В., Т. П. Храмых, and Л. О. Барская. "Endogenous intoxication associated with anesthetic preconditioning in hemorrhagic hypotension." Nauchno-prakticheskii zhurnal «Patogenez», no. 4 (December 25, 2020): 49–54. http://dx.doi.org/10.25557/2310-0435.2020.04.49-54.

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Актуальность. Интерес к возможности уменьшения эндогенной интоксикации при острой массивной кровопотере, сопровождающей обширные сочетанные травмы и оперативные вмешательства, растёт. Феномен анестезиологического прекондиционирования обсуждается активно, так как появилась возможность дополнительной протекции различных органов и систем организма. Цель исследования: оценка параметров эндогенной интоксикации на фоне анестезиологического прекондиционирования севофлюраном при геморрагической гипотензии. Материалы и методы. Эксперимент выполнен на 100 белых беспородных крысах-самцах: 2 группы контро

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Azarnova, T. O., A. Yu Sidorova, S. V. Pozyabin, I. S. Lugovaya, D. V. Anshakov, and L. A. Zolotukhina. "The use of water-soluble form of ubikhinone for leveling oxidative stress in chicken embryos as a method for optimizing the hematological status." Veterinariya, Zootekhniya i Biotekhnologiya 1, no. 8 (2021): 51–61. http://dx.doi.org/10.36871/vet.zoo.bio.202108006.

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The incubation eggs were treated with solutions of a water-soluble form of ubiquinone in order to neutralize the negative consequences of the development of oxidative stress in chick embryos under conditions of artificial incubation to optimize the hematological status in their body. The results showed that the implementation, first of all, of the antioxidant properties of the claimed metabolite made it possible to obtain the values of the central hematological indices, indicating a decrease in the body of individuals of the best experimental group of endogenous intoxication, an increase in st

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Pylypchuk, T. P., and I. Ya Krynytska. "THE INVESTIGATION OF THE ENDOGENOUS INTOXICATION INDICES IN RATS IN THE DYNAMICS OF THE CRUSHSYNDROME DEVELOPMENT." Bulletin of Problems Biology and Medicine 1, no. 2 (2019): 171. http://dx.doi.org/10.29254/2077-4214-2019-1-2-149-171-175.

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Konoplitsky, V. S., V. V. Motygin, A. G. Yakimenko, D. V. Dmytriiev, and T. I. Mikhalchuk. "Mathematical modeling for prediction of complicated acute appendicitis in children." Perioperaciina Medicina 1, no. 1 (2018): 70–80. http://dx.doi.org/10.31636/prmd.v1i1.10.

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Endogenous intoxication, which accompanies the complicated course of acute appendicitis in children, is one of the serious conditions, which are the main cause of complications in the postoperative period. Diverse clinical observations done by clinicians suggest that despite the use of modern technologies in operating equipment, anesthetic support, the number of complications in the postoperative period has no tendency to decrease, and the main cause of lethal outcomes with appendicular peritonitis is lightning development of severe degree of endotoxicosis, which develops as a result of resorb

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Kozitsyna, A. I., L. Yu Karpenko, and A. A. Bakhta. "Leukocyte indices in dogs with acquired primary hypothyroidism." Russian Journal of Immunology 27, no. 3 (2024): 477–82. http://dx.doi.org/10.46235/1028-7221-16747-lii.

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According to global statistics, hypothyroidism in dogs is a widespread disease. However, due to certain difficulties in conducting laboratory diagnostics, as well as the cross-species specificity of such indicators as thyroid-stimulating hormone, thyroglobulin autoantibodies, prompt diagnosis and differentiation of hypothyroidism in dogs in the practice of a veterinarian is difficult. Thus, it is relevant to search for secondary auxiliary methods of diagnosis and detection of hypothyroidism in dogs based on a set of indicators and diagnostic coefficients-indices. Since hypothyroidism causes an

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Goroshinskaya, Irina A., A. N. Shevchenko, E. V. Filatova, P. S. Kachesova, L. A. Nemashkalova, and A. V. Chudilova. "EFFECT OF INTRAVESICAL CHEMOTHERAPY, MODIFIED BY ELECTROMAGNETIC FIELD IN THE SCANNING MODE, ON THE LEVEL OF ENDOTOXEMIA AND OXIDATIVE PROCESSES IN THE BLOOD IN PATIENTS WITH BLADDER CANCER." Russian Journal of Oncology 22, no. 3 (2017): 142–48. http://dx.doi.org/10.18821/1028-9984-2017-22-3-142-148.

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Muscle-non-invasive bladder cancer (MNIBC) accounts of 70% of malignant lesions of this localization and has a high rate of recurrence and complications after treatment that requires improvement of the management of such patients. The developed modification of adjuvant intravesical chemotherapy (IVCT) necessitates the evaluation of endotoxemia and the adequacy of antioxidant protection of patients. The purpose of the study is the assessment of indices that reflect the functional state of albumin, the severity of endogenous intoxication (EI) and the state of free radical oxidation in the blood

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Karpunina, T. I., A. P. Godovalov, and Yu B. Busyrev. "TECHNICAL ASPECTS OF EVALUATING CYTOKINE PROFILE AND LEUKOCYTE REACTION IN BILE DUCT OBTURATION OF DIFFERENT ORIGIN." Medical Immunology (Russia) 20, no. 6 (2018): 825–32. http://dx.doi.org/10.15789/1563-0625-2018-6-825-832.

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The study was carried out to assess the prospects for the combined use of leukocyte and cytokine indices in the bile duct obstruction of different genesis.We have performed a study of the patients with mechanical jaundice, either due to tumor (14 persons), or non-tumor genesis (16 persons). Concentrations of cytokines (IL-1, IL-4, IL-8, TNFα) were determined in blood serum before surgical intervention. The total activity of endogenous inflammatory mediators in the serum of patients was estimated as an index of inflammatory activity (IVA), which was calculated using the following formula: IVA =

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Sharipova, V. Kh, S. Beridze, O. O. Pidmurniak, et al. "The first data on international multicenter clinical study RheoSTAT-CP0620 on the efficacy and safety of Rheosorbilact® infusion in therapy of sepsis." Infusion & Chemotherapy, no. 2 (May 20, 2022): 11–20. http://dx.doi.org/10.32902/2663-0338-2022-2-11-20.

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Sepsis stays a common and life-threatening pathological condition; hospital mortality in patients with sepsis exceeds 30 %. Fluid resuscitation is an important component of sepsis treatment. The purpose of this work was to evaluate the efficacy and safety of the multicomponent infusion solution Rheosorbilact in the treatment of patients with sepsis. The international multicenter randomized study RheoSTAT-CP0620 included 180 patients aged 18 to 60 years diagnosed with sepsis. Patients received Rheosorbilact therapy in dosage according to the package insert. A change in the SOFA score on day 3 o

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