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Journal articles on the topic 'Endogenous melatonin'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Reiter, Russel J., Sergio Rosales-Corral, and Ramaswamy Sharma. "Melatonin: Protection of the Intervertebral Disc." Melatonin Research 2, no. 3 (2019): 1–9. http://dx.doi.org/10.32794/mr11250028.

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Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies. The loss of work time as a result of this problem is massive. Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actio

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2

LI, Beibei, Hongjian ZHANG, Mohammed AKBAR, and Hee-Yong KIM. "Negative regulation of cytosolic phospholipase A2 by melatonin in the rat pineal gland." Biochemical Journal 351, no. 3 (2000): 709–16. http://dx.doi.org/10.1042/bj3510709.

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In this paper evidence that supports a new role for melatonin as a negative endogenous regulator of cytosolic phospholipase A2 (cPLA2) is presented. When rat pineal glands were incubated in culture, time-dependent release of arachidonic acid (AA) was observed, which was significantly inhibited by a known 85-kDa cPLA2 inhibitor, methyl arachidonyl fluorophosphonate. Co-incubation with melatonin inhibited the AA release in a concentration-dependent manner, and this decrease was accompanied by a reduction of cPLA2 protein and mRNA expression. Melatonin-receptor agonists, 2-iodo-N-butanoyl-5-metho

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Tang, Kuo-Shu, Chun-Yi Ho, Chien-Ning Hsu, and You-Lin Tain. "Melatonin and Kidney Health: From Fetal Stage to Later Life." International Journal of Molecular Sciences 24, no. 9 (2023): 8105. http://dx.doi.org/10.3390/ijms24098105.

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Melatonin, an endogenous hormone mainly released at night by the pineal gland, has multifaceted biofunctions. Emerging evidence points to melatonin having a crucial role in kidney health and disease. As the prevalence of chronic kidney disease (CKD) is still rising, a superior strategy to advance global kidney health is needed to not just treat CKD, but prevent it early on. Adult kidney disease can have its origins in early life. This review aims to evaluate the recent literature regarding melatonin’s effect on kidney development, its clinical uses in the early stage of life, animal models doc

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Moretti, Enrico, Gaia Favero, Luigi Fabrizio Rodella, and Rita Rezzani. "Melatonin’s Antineoplastic Potential Against Glioblastoma." Cells 9, no. 3 (2020): 599. http://dx.doi.org/10.3390/cells9030599.

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Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients’ expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin’s activity against several cancer hallmarks, there is growing interest in its use for preventing and treating cancer. In this review, we report on the potential effects of melatonin, alone or in combination with anticancer drugs, against GB

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Sohn, Eun-Hwa, Su-Nam Kim, and Sung-Ryul Lee. "Melatonin’s Impact on Wound Healing." Antioxidants 13, no. 10 (2024): 1197. http://dx.doi.org/10.3390/antiox13101197.

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Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin’s effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. Whil

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6

Yang, Xiaoxiao, Qifeng Shi, Xinru Wang, et al. "Melatonin-Induced Chromium Tolerance Requires Hydrogen Sulfide Signaling in Maize." Plants 13, no. 13 (2024): 1763. http://dx.doi.org/10.3390/plants13131763.

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Both melatonin and hydrogen sulfide (H2S) mitigate chromium (Cr) toxicity in plants, but the specific interaction between melatonin and H2S in Cr detoxification remains unclear. In this study, the interaction between melatonin and H2S in Cr detoxification was elucidated by measuring cell wall polysaccharide metabolism and antioxidant enzyme activity in maize. The findings revealed that exposure to Cr stress (100 μM K2Cr2O7) resulted in the upregulation of L-/D-cysteine desulfhydrase (LCD/DCD) gene expression, leading to a 77.8% and 27.3% increase in endogenous H2S levels in maize leaves and ro

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Hodzic, Elvisa, Milica Balaban, Nevena Suskalo, Semira Galijasevic, Dino Hasanagic, and Biljana Kukavica. "Antioxidative response of Melissa officinalis L. and Valeriana officinalis L. leaves exposed to exogenous melatonin and excessive zinc and cadmium level." Journal of the Serbian Chemical Society 84, no. 1 (2019): 11–25. http://dx.doi.org/10.2298/jsc180504070h.

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Heavy metals disturb the redox homeostasis of the plant cell. The indolamine hormone, melatonin, protects plants from oxidative damage by directly scavenging reactive oxygen species or by stimulating the activity of antioxidant enzymes. The antioxidative role of melatonin in the leaves of two medicinal plants, lemon balm (Melissa officinalis L.) and valerian (Valeriana officinalis L.) that were treated with increased concentrations of Zn and Cd 24 h after sowing at an open field, were investigated. The plants were treated with Zn, Cd, melatonin and a mixture of melatonin with the mentioned met

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8

Claustrat, Bruno, Jocelyne Brun, Martine Geoffriau, and Guy Chazot. "Melatonin: From the Hormone to the Drug?" Restorative Neurology and Neuroscience 12, no. 2-3 (1998): 151–57. https://doi.org/10.3233/rnn-1998-00031.

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Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin production according to the light schedule. The nycthohemeral rhythm of this hormone is determined by repeated measurement of plasma of saliva MLT or urine sulfatoxymelatonin, the main hepatic metabolite. Melatonin can be considered as the output (the hand) of the endogenous clock. S

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9

Aashish1, Ravi Kumar Yadav2. "Role of the pineal gland, endogenous opioids and neuropeptides in reproduction." Vet Farm Frontier 02, no. 02 (2025): 65–69. https://doi.org/10.5281/zenodo.15014297.

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T he pineal governs or participates in the command of many bodily functions by means of its endocrine action, using mechanisms and physiological correlations that are presently not fully explained. Investigations in both animals and humans have provided evidence that the gland plays an important role in the regulation of both the circadian and seasonal rhythms in a variety of species (Masson Pevet and Gauer,1994). It recently was shown that the gland has a significant role in regulating the seasonal reproductive behaviors of animals that breed seasonally. Primarily in follicular growth, melato

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10

Boatright, Jeffrey H., Nara M. Rubim, and P. Michael Iuvone. "Regulation of endogenous dopamine release in amphibian retina by melatonin: The role of GABA." Visual Neuroscience 11, no. 5 (1994): 1013–18. http://dx.doi.org/10.1017/s0952523800003941.

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AbstractIn the retina of the African clawed frog (Xenopus laevis), endogenous dopamine release increases in light and decreases in darkness. Exogenous melatonin and several chemical analogs of melatonin suppressed light-evoked dopamine release from frog retina in a concentration-dependent manner. The rank order of potency for inhibition of light-evoked dopamine release was melatonin » 5-methoxytryptamine ≥ N-acetylserotonin > 5-methoxytryptophol ⋙ serotonin. Melatonin did not suppress dopamine release below levels seen in darkness. The putative melatonin receptor antagonist luzindole inhibi

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ZHANG, Hongjian, Mohammed AKBAR, and Hee-Yong KIM. "Melatonin: an endogenous negative modulator of 12-lipoxygenation in the rat pineal gland." Biochemical Journal 344, no. 2 (1999): 487–93. http://dx.doi.org/10.1042/bj3440487.

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Major biochemical activities of the pineal gland include melatonin biosynthesis and 12-lipoxygenation. In this paper, we provide evidence in vivo that melatonin regulates 12-lipoxygenation via 12-lipoxygenase (LOX) expression. The relationship between these two biochemical activities was established by monitoring levels of endogenous melatonin and a 12-LOX metabolite, 12-hydroxyeicosatetraenoic acid (12-HETE), in the rat pineal gland both during the light-dark cycle and after isoproterenol injection using GC/MS with negative ion chemical ionization. As pineal melatonin production reflected a t

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12

Yang, Minghui, Shengyu Guan, Jingli Tao, et al. "Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells." Biology of Reproduction 104, no. 6 (2021): 1322–36. http://dx.doi.org/10.1093/biolre/ioab046.

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Abstract Leydig cells play a critical role in male reproductive physiology, and their dysfunction is usually associated with male infertility. Melatonin has an important protective and regulatory role in these cells. However, the lack of suitable animal models impedes us from addressing the impact of endogenous melatonin on these cells. In the current study, by using arylalkylamine N-acetyltransferase (AANAT) overexpression transgenic sheep and AANAT knockout mice, we confirmed the regulatory effects of endogenously occurring melatonin on Leydig cells as well as its beneficial effects on male

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13

Hwang, Ok Jin, and Kyoungwhan Back. "Molecular Regulation of Antioxidant Melatonin Biosynthesis by Brassinosteroid Acting as an Endogenous Elicitor of Melatonin Induction in Rice Seedlings." Antioxidants 11, no. 5 (2022): 918. http://dx.doi.org/10.3390/antiox11050918.

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Gibberellic acid (GA) was recently shown to induce melatonin synthesis in rice. Here, we examined whether brassinosteroids (BRs) also induce melatonin synthesis because BRs and GA show redundancy in many functions. Among several plant hormones, exogenous BR treatment induced melatonin synthesis by twofold compared to control treatment, whereas ethylene, 6-benzylaminopurine (BA), and indole-3-acetic acid (IAA) showed negligible effects on melatonin synthesis. Correspondingly, BR treatment also induced a number of melatonin biosynthetic genes in conjunction with the suppression of melatonin cata

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14

Contreras-Correa, Zully E., Riley D. Messman, Rebecca M. Swanson, and Caleb O. Lemley. "Melatonin in Health and Disease: A Perspective for Livestock Production." Biomolecules 13, no. 3 (2023): 490. http://dx.doi.org/10.3390/biom13030490.

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Mounting evidence in the literature indicates an important role of endogenous and exogenous melatonin in driving physiological and molecular adaptations in livestock. Melatonin has been extensively studied in seasonally polyestrous animals whereby supplementation studies have been used to adjust circannual rhythms in herds of animals under abnormal photoperiodic conditions. Livestock undergo multiple metabolic and physiological adaptation processes throughout their production cycle which can result in decreased immune response leading to chronic illness, weight loss, or decreased production ef

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Burgess, Helen J., Tracey Sletten, Natasha Savic, Saul S. Gilbert, and Drew Dawson. "Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night." Journal of Applied Physiology 91, no. 3 (2001): 1214–22. http://dx.doi.org/10.1152/jappl.2001.91.3.1214.

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Melatonin increases sleepiness, decreases core temperature, and increases peripheral temperature in humans. Melatonin may produce these effects by activating peripheral receptors or altering autonomic activity. The latter hypothesis was investigated in 16 supine subjects. Three conditions were created by using bright light and exogenous melatonin: normal endogenous, suppressed, and pharmacological melatonin levels. Data during wakefulness from 1.5 h before to 2.5 h after each subject's estimated melatonin onset (wake time + 14 h) were analyzed. Respiratory sinus arrhythmia (cardiac parasympath

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Hernando, Marcelo P., Joaquín Cogo Pagella, and Claudio Osvaldo Cervino. "The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats." Melatonin Research 7, no. 1 (2024): 103–19. http://dx.doi.org/10.32794/mr112500170.

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Melatonin is a potent endogenously occurring antioxidant with the pleiotropic activities to neurodegenerative diseases associated with brain oxidative damage. In this study, we examined the prolonged photoperiodic alterations and iron (Fe) overload on melatonin production and brain oxidative stress in rats. The result showed that the 15 days of constant light (CL) exposure did not low the melatonin production but the 15 days of constant darkness (CD) significantly increased serum melatonin level in rats. The Fe treatment in both CL and CD conditions significantly reduced endogenous melatonin l

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17

Song, Runxian, Faujiah Nurhasanah Ritonga, Haiyang Yu, Changjun Ding, and Xiyang Zhao. "Plant Melatonin: Regulatory and Protective Role." Horticulturae 8, no. 9 (2022): 810. http://dx.doi.org/10.3390/horticulturae8090810.

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Melatonin is an antioxidant that is widely distributed in plants and animals. It is a conservative molecule. In early studies, scientists often used isolation and identification techniques to observe whether the endogenous melatonin cycle in plants was related to the external photoperiod, plant growth, and development cycles, including seed germination, plant rooting, and floral induction. With the development of isolation and identification technology, there is ample evidence that plants possess a variety of melatonin-synthesis pathways. The comprehensive application of molecular biology, gen

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18

Cai, Zongye, Theo Klein, Laurie W. Geenen, et al. "Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension." Journal of Clinical Medicine 9, no. 5 (2020): 1248. http://dx.doi.org/10.3390/jcm9051248.

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Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms are involved, with melatonin exerting anti-oxidant and anti-inflammatory effects, as well as inducing vasodilation and cardio-protection. However, endogenous levels of melatonin in treatment-naïve patients with PH and their clinical significance are still unknown. Plasma levels of endogenous melatonin were measured by liquid chromatography-tandem mass spectrometry in PH patients (n = 64, 43 pulmonary arterial hypertension (PAH) and 21 chronic thromboembol

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Carrillo-Vico, Antonio, Patricia J. Lardone, José M. Fernández-Santos, et al. "Human Lymphocyte-Synthesized Melatonin Is Involved in the Regulation of the Interleukin-2/Interleukin-2 Receptor System." Journal of Clinical Endocrinology & Metabolism 90, no. 2 (2005): 992–1000. http://dx.doi.org/10.1210/jc.2004-1429.

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Since melatonin was first isolated in 1958 up to the last few years, this substance was considered a hormone exclusive to the pineal gland. Although melatonin has lately been identified in a large number of extrapineal sites, its potential biological actions have not yet been studied. This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine, both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatoni

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Van Den Heuvel, Cameron J., David J. Kennaway, and Drew Dawson. "Effects of daytime melatonin infusion in young adults." American Journal of Physiology-Endocrinology and Metabolism 275, no. 1 (1998): E19—E26. http://dx.doi.org/10.1152/ajpendo.1998.275.1.e19.

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Daytime oral melatonin typically exerts soporific and thermoregulatory effects; however, it is not clear whether these effects reflect the normal physiological response to endogenous nocturnal melatonin production. We infused melatonin at doses that produced physiological and supraphysiological steady-state levels in 24 young adults during two daytime bed rest protocols. From 1000 to 1630, subjects were infused intravenously with saline or melatonin in counterbalanced order. Each group of eight subjects received melatonin (and saline) infusions at one dose rate: 0.04 μg ⋅ h−1 ⋅ kg body wt−1 (l

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21

Lapwood, Keith R., Lakshmi Bhagat, and Mark P. Simpson. "Analgesic effects on endogenous melatonin secretion." Journal of Pineal Research 22, no. 1 (1997): 20–25. http://dx.doi.org/10.1111/j.1600-079x.1997.tb00298.x.

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Tian, Qiang, Guangzheng Wang, Jianhua Dou, et al. "Melatonin Modulates Tomato Root Morphology by Regulating Key Genes and Endogenous Hormones." Plants 13, no. 3 (2024): 383. http://dx.doi.org/10.3390/plants13030383.

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Melatonin plays a vital role in plant growth and development. In this study, we treated hydroponically grown tomato roots with various concentrations of exogenous melatonin (0, 10, 30, and 50 μmol·L−1). We utilized root scanning and microscopy to examine alterations in root morphology and cell differentiation and elucidated the mechanism by which melatonin regulates these changes through the interplay with endogenous hormones and relevant genes. The results showed that for melatonin at concentrations ranging between 10 and 30 μmol·L−1, the development of lateral roots were significantly stimul

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Dhali, Tapan, Mona Sharma, and Priyanka Hemrajani. "Melatonin - A Cutaneous Perspective." Nepal Journal of Dermatology, Venereology & Leprology 19, no. 2 (2021): 3–12. http://dx.doi.org/10.3126/njdvl.v19i2.39452.

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Melatonin (MLT) is an endogenous hormone secreted from the pineal gland, located deep in the brain in the epithalamus associated with numerous biological activities. The primary function of melatonin is to regulate sleep-wake cycles. However, research over the last few years has enlightened a range of functions associated with this molecule, including anti-inflammatory, direct and indirect antioxidant activity, regenerative tissue benefits, and preservation of mitochondrial function. Melatonin’s anti-inflammatory and antioxidant support, coupled with its mitochondrial modulation, makes it a vi

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Budnevsky, A. V., E. S. Ovsyannikov, N. V. Rezova, and Ya S. Shkatova. "Melatonin and hypertension: a possible role in combination therapy." Terapevticheskii arkhiv 89, no. 12 (2017): 122–26. http://dx.doi.org/10.17116/terarkh20178912122-126.

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This literature review gives the results of clinical trials studying the association of the level of endogenous melatonin and blood pressure (BP), the effects of exogenous melatonin on BP (particularly at night) in relation to the used rapid- or controlled-release formulation of melatonin.

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Fan, Yufeng, Lingling Li, Fenghui Guo, and Xiangyang Hou. "Tolerance of Forage Grass to Abiotic Stresses by Melatonin Application: Effects, Mechanisms, and Progresses." Agriculture 14, no. 2 (2024): 171. http://dx.doi.org/10.3390/agriculture14020171.

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Climate change related abiotic stress has been potentially impacting the quantity and quality of forage grass. Melatonin, a multifunctional molecule that has been found to be present in all plants examined to date, plays a crucial role in improving forage grass tolerance to both biotic and abiotic stresses. However, research on melatonin’s role in forage grass is still developing. In this review, the effects of melatonin application on abiotic stress are the primary topic, and we try to find relative mechanisms. In order to determine whether melatonin has a good effect on forage grass, we comp

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Strassman, R. J., C. R. Qualls, E. J. Lisansky, and G. T. Peake. "Elevated rectal temperature produced by all-night bright light is reversed by melatonin infusion in men." Journal of Applied Physiology 71, no. 6 (1991): 2178–82. http://dx.doi.org/10.1152/jappl.1991.71.6.2178.

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Early morning rectal body temperature is lowest when melatonin levels are highest in humans. Although pharmacological doses of melatonin are hypothermic in humans, the relationship between endogenous melatonin and temperature level has not been investigated. We measured rectal body temperature in nine normal men whose melatonin levels were suppressed by all-night sleep deprivation in bright light and compared values with those seen in sleep in the dark, sleep deprivation in dim light (to control for the stimulatory effect of wakefulness on temperature), and sleep deprivation in bright light wi

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Mathes, Alexander M., Paul Heymann, Christian Ruf, et al. "Endogenous and Exogenous Melatonin Exposure Attenuates Hepatic MT1 Melatonin Receptor Protein Expression in Rat." Antioxidants 8, no. 9 (2019): 408. http://dx.doi.org/10.3390/antiox8090408.

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Melatonin receptors are highly relevant for the hepatoprotective effects of the pineal hormone melatonin after experimental hemorrhagic shock in rats. In this study, we sought to determine the spatial expression pattern and a putative regulation of two melatonin receptors, membrane bound type 1 and 2 (MT1 and MT2), in the liver of rats. In a male rat model (Sprague Dawley) of hemorrhage and resuscitation, we investigated the gene expression and protein of MT1 and MT2 in rat liver by utilizing real-time quantitative polymerase chain reaction, a western blot analysis, and immunohistochemistry. P

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Miranda-Riestra, Armida, Rosa Estrada-Reyes, Erandis D. Torres-Sanchez, Silvia Carreño-García, Genaro Gabriel Ortiz, and Gloria Benítez-King. "Melatonin: A Neurotrophic Factor?" Molecules 27, no. 22 (2022): 7742. http://dx.doi.org/10.3390/molecules27227742.

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Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal environment with the photoperiod. It is synthesized in the pineal gland and greatly depends on the endogenous circadian clock located in the suprachiasmatic nucleus and the retina’s exposure to different light intensities. Among its most studied functions are the regulation of the waking-sleep rhythm and body temperature. Furthermore, melatonin has pleiotropic actions, which affect, for instance, the modulation of the immune and the cardiovascular systems, as well as the neuroprotection achieved by scavenging

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Berzosa, César, Pablo Jesús Bascuas, and Eduardo Piedrafita. "Effects of Melatonin Administration on Physical Performance and Biochemical Responses Following Exhaustive Treadmill Exercise." Current Issues in Molecular Biology 46, no. 12 (2024): 13647–61. https://doi.org/10.3390/cimb46120815.

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Exercise, despite being a beneficial activity for health, can also be a source of oxidative imbalance, which can lead to a decrease in performance. Furthermore, melatonin is an endogenous molecule that may counteract exercise-induced oxidative stress. The aim of this study was to evaluate the potential ergogenic and antioxidant capacity of melatonin administered for a maximal effort test. A total of 30 rats were divided into three groups—control, exercise, and exercise + melatonin (intraperitoneal administration of 10 mg/kg)—to assess the effects of an exhaustive incremental protocol in the tw

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Zhdanova, I. V., R. J. Wurtman, A. Balcioglu, A. I. Kartashov, and H. J. Lynch. "Endogenous Melatonin Levels and the Fate of Exogenous Melatonin: Age Effects." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 53A, no. 4 (1998): B293—B298. http://dx.doi.org/10.1093/gerona/53a.4.b293.

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Pal, Palash K., Aindrila Chattopadhyay, and Debasish Bandyopadhyay. "Functional interplay of melatonin in the bile duct and gastrointestinal tract to mitigate disease development: An overview." Melatonin Research 4, no. 1 (2021): 118–40. http://dx.doi.org/10.32794/mr11250086.

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Prevalence of bile duct and gastrointestinal (GI) tract associated diseases is increasing globally. Commonly, the bile duct epithelial cell (cholangiocytes) malfunction and its uncontrolled proliferation often cause liver fibrosis and tumorigenesis, particularly the cholangiocarcinoma. Specifically, GI tract is constantly under diverse endogenous and exogenous stressors which interrupt GI physiological functions and promote inflammation, tissue damage, ulceration, gastrointestinal bleeding, gastroesophageal reflux disease (GERD), irritable bowel disease (IBD) and gastritis. On the other hand,

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Shan, Qiaobo, Weicheng Liu, Xiaoxiao Ni, et al. "Serotonin Mitigates ColdStress-Induced Damage in Kandelia obovata Through Modulating the Endogenous Melatonin- and Abscisic Acid Biosynthesis." International Journal of Molecular Sciences 26, no. 4 (2025): 1635. https://doi.org/10.3390/ijms26041635.

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Endogenous melatonin (MEL) and abscisic acid (ABA) are involved in the adaptation of plants to environmental stresses. The application of exogenous serotonin (SER) to plants can enhance their tolerance to abiotic stress, such as cold. However, the mechanism associated with serotonin-mediated defense against cold-induced damage in mangroves is still poorly understood. In this study, we demonstrated that mangrove (Kandelia obovata) seedlings sprayed with 200 μmol·L−1 serotonin exhibited enhanced cold tolerance, as shown by reduced damage to leaves and loss of photosynthesis when exposed to low-t

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Gutierrez Higueras, T., F. Calera Cortés, A. Trives Muñoz, S. Vicent Forés, and S. Sainz De La Cuesta Alonso. "Attempted suicide by Melatonin overdose: Case report and literature review." European Psychiatry 65, S1 (2022): S836—S837. http://dx.doi.org/10.1192/j.eurpsy.2022.2166.

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Introduction Melatonine (N-acetyl-5-methoxytryptamine) is an endogenous neurohormone produced by pineal gland. It is related to sleep-wake circadian rhythms, and nowdays it is sold without prescription as a “natural treatment” for sleep disorders. Most common side effects of melatonin overdose are drowsiness, dizziness, fatigue, headache, confusion, nightmare, hypotension, tachycardia and hypothermia. Supportive measures and control of vital signs are essential for an early discharge of the patient. Objectives To present a case of an 42-year-old woman who was taken to the emergency department

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Seifman, Marc A., Alexios A. Adamides, Phuong N. Nguyen, et al. "Endogenous Melatonin Increases in Cerebrospinal Fluid of Patients after Severe Traumatic Brain Injury and Correlates with Oxidative Stress and Metabolic Disarray." Journal of Cerebral Blood Flow & Metabolism 28, no. 4 (2008): 684–96. http://dx.doi.org/10.1038/sj.jcbfm.9600603.

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Oxidative stress plays a significant role in secondary damage after severe traumatic brain injury (TBI); and melatonin exhibits both direct and indirect antioxidant effects. Melatonin deficiency is deleterious in TBI animal models, and its administration confers neuroprotection, reducing cerebral oedema, and improving neurobehavioural outcome. This study aimed to measure the endogenous cerebrospinal fluid (CSF) and serum melatonin levels post-TBI in humans and to identify relationships with markers of oxidative stress via 8-isoprostaglandin-F2α (isoprostane), brain metabolism and neurologic ou

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Vidiker, R. V., N. V. Trubina, and A. R. Babaeva. "Circulating neurotransmitter levels in irritable bowel syndrome: correlation of laboratory tests and clinical findings." South Russian Journal of Therapeutic Practice 1, no. 2 (2020): 72–77. http://dx.doi.org/10.21886/2712-8156-2020-1-2-72-77.

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Objective: to estimate blood levels of serotonin and melatonin neurotransmitters in patients with irritable bowel syndrome and to evaluate the role of neurohumoral imbalance in the development and clinical manifestations of irritable bowel syndrome phenotypes.Materials and methods: the study included 60 patients (range, 18 – 45 years) diagnosed with irritable bowel syndrome according to the Roman IV criteria for irritable bowel syndrome (2016). 20 patients with a confirmed diagnosis of ulcerative colitis (UC) were assigned to a comparison group. The control group was composed of 45 apparently

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Zakaria, Rahimah, A. H. Ahmad, and Z. Othman. "The Potential Role of Melatonin on Memory Function: Lessons from Rodent Studies." Folia Biologica 62, no. 5 (2016): 181–87. http://dx.doi.org/10.14712/fb2016062050181.

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Pineal melatonin biosynthesis is regulated by the circadian clock located in the suprachiasmatic nucleus of the hypothalamus. Melatonin has been found to modulate the learning and memory process in human as well as in animals. Endogenous melatonin modulates the process of newly acquired information into long-term memory, while melatonin treatment has been found to reduce memory deficits in elderly people and in various animal models. However, the mechanisms mediating the enhancing effect of melatonin on memory remain elusive. This review intends to explore the possible mechanisms by looking at

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Othman, Zahiruddin, Rahimah Zakaria, and Asma Hayati Ahmad. "The Potential Role of Melatonin on Memory Function: Lessons from Rodent Studies." Folia Biologica (Praha) 62, no. 5 (2016): 181–87. https://doi.org/10.5281/zenodo.2597375.

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Pineal melatonin biosynthesis is regulated by the circadian clock located in the suprachiasmatic nucleus of the hypothalamus. Melatonin has been found to modulate the learning and memory process in human as well as in animals. Endogenous melatonin modulates the process of newly acquired information into long-term memory, while melatonin treatment has been found to reduce memory deficits in elderly people and in various animal models. However, the mechanisms mediating the enhancing effect of melatonin on memory remain elusive. This review intends to explore the possible mechanisms by looking at

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Li, Zhuo, Xiaoyu Su, Yulu Chen, et al. "Melatonin Improves Drought Resistance in Maize Seedlings by Enhancing the Antioxidant System and Regulating Abscisic Acid Metabolism to Maintain Stomatal Opening Under PEG-Induced Drought." Journal of Plant Biology 64, no. 4 (2021): 299–312. http://dx.doi.org/10.1007/s12374-021-09297-3.

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AbstractMaize (Zea mays L.) is highly sensitive to drought stress, resulting in large losses in yield; therefore, strategies aimed at enhancing drought tolerance are essential. Melatonin improves stress tolerance in plants; however, its mechanism in maize seedlings under drought stress remains unknown. Therefore, we investigated the effects of foliar-sprayed melatonin (100 umol L−1) on the antioxidant system, photosynthetic gas exchange parameters, stomatal behavior, endogenous melatonin and abscisic acid (ABA)-related gene expression in maize seedling leaves under 20% polyethylene glycol (PEG

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Kamieniak, Maciej, Kamil Kośmider, Barbara Miziak, and Stanisław J. Czuczwar. "The Oxidative Stress in Epilepsy—Focus on Melatonin." International Journal of Molecular Sciences 25, no. 23 (2024): 12943. https://doi.org/10.3390/ijms252312943.

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Oxidative stress develops when there is an excess of oxidants leading to molecular and cellular damage. Seizure activity leads to oxidative stress and the resulting increased lipid peroxidation. Generally, antiseizure medications reduce oxidative stress, although the data on levetiracetam are ambiguous. Exogenous antioxidants (vitamin E, resveratrol, hesperidin, and curcumin) have been documented to exert an anticonvulsant effect in animal models of seizures and some recent clinical data point to curcumin as an affective adjuvant for the therapy of pediatric intractable epilepsy. Melatonin is

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Cortés-Montaña, Daniel, María Josefa Bernalte-García, Manuel Joaquín Serradilla, and Belén Velardo-Micharet. "Optimal Preharvest Melatonin Applications to Enhance Endogenous Melatonin Content, Harvest and Postharvest Quality of Japanese Plum." Agriculture 13, no. 7 (2023): 1318. http://dx.doi.org/10.3390/agriculture13071318.

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Plum is one of the most produced stone fruits worldwide. Melatonin is an environmentally eco-friendly substance that, in low concentrations, activates defence systems against biotic and abiotic stresses. This substance is considered a tool that could increase fruit quality. This study aimed to evaluate the impact of different preharvest foliar applications with different melatonin concentrations (0.1, 0.3, 0.5 mmol L−1) to enhance melatonin content and shelf life of ‘Primetime’ plum. To this purpose, two and three applications were carried out at different critical stages of fruit growth. Diff

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Stewart, Lee S. "Endogenous Melatonin and Epileptogenesis: Facts and Hypothesis." International Journal of Neuroscience 107, no. 1-2 (2001): 77–85. http://dx.doi.org/10.3109/00207450109149758.

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ROHDE, BROOKS H., MARSHA A. McLAUGHLIN, and LINDA Y. CHIOU. "Existence and Role of Endogenous Ocular Melatonin." Journal of Ocular Pharmacology and Therapeutics 1, no. 3 (1985): 235–43. http://dx.doi.org/10.1089/jop.1985.1.235.

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Tuunainen, A. "Depression and endogenous melatonin in postmenopausal women." Journal of Affective Disorders 69, no. 1-3 (2002): 149–58. http://dx.doi.org/10.1016/s0165-0327(01)00303-2.

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Orlova, S. V., E. A. Nikitina, N. V. Balashova, Yu A. Pigareva, E. V. Ankvab, and T. I. Khadzhimuratova. "The role of exogenous melatonin in the regulation of sleep." Medical alphabet, no. 25 (November 25, 2022): 26–33. http://dx.doi.org/10.33667/2078-5631-2022-25-26-33.

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Melatonin is a natural hormone produced by the pineal gland and is a derivative of serotonin. One of the key properties of melatonin is its chronobiological ability, realized by multilevel synchronization of biological processes. Physiologically, melatonin secretion increases at night and decreases in the morning. At present, the role of melatonin in the regulation of sleep, circadian rhythms, and adaptation of the body to a rapid change in time zones has been proven. With a decrease in the production of endogenous melatonin in a number of people (with a disorder of daily biorhythms due to lon

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Zhu, Ying, Hang Gao, Mengxin Lu, et al. "Melatonin-Nitric Oxide Crosstalk and Their Roles in the Redox Network in Plants." International Journal of Molecular Sciences 20, no. 24 (2019): 6200. http://dx.doi.org/10.3390/ijms20246200.

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Melatonin, an amine hormone highly conserved during evolution, has a wide range of physiological functions in animals and plants. It is involved in plant growth, development, maturation, and aging, and also helps ameliorate various types of abiotic and biotic stresses, including salt, drought, heavy metals, and pathogens. Melatonin-related growth and defense responses of plants are complex, and involve many signaling molecules. Among these, the most important one is nitric oxide (NO), a freely diffusing amphiphilic biomolecule that can easily cross the cell membrane, produce rapid signal respo

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Orlova, Victoria V., Lidiia V. Suslikova, Olena A. Orlova, Dmytro V. Dmytriienko, and Iryna V. Malysheva. "ASSISTED REPRODUCTIVE TECHNOLOGY EFFICIENCY IMPROVEMENT OF TUBAL-PERITONEAL INFERTILITY." Wiadomości Lekarskie 73, no. 11 (2020): 2370–77. http://dx.doi.org/10.36740/wlek202011109.

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The aim: This study aims to develop and implement a complex of pregravid preparation based on endogenous melatonin level, development of oxidative stress and violation of apoptosis regulation in women with tubal-peritoneal infertility. Materials and methods: We have examined 100 women of reproductive age, including 65 women with tubal-peritoneal infertility treated by ART. All studied women were defined levels of endogenous melatonin, oxidative status and level of apoptosis in the endometrium and in follicular fluid (infertile women only). As a powerful free radical neutralizer, we used melato

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GRACE, MICHAEL S., ATSUHIKO CHIBA, and MICHAEL MENAKER. "Circadian control of photoreceptor outer segment membrane turnover in mice genetically incapable of melatonin synthesis." Visual Neuroscience 16, no. 5 (1999): 909–18. http://dx.doi.org/10.1017/s0952523899165106.

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Vertebrate retinal photoreceptors periodically shed membrane from their outer segment distal tips; this material is phagocytosed and degraded by the retinal pigmented epithelium. Both a circadian oscillator and the daily light–dark cycle affect disk shedding, and the effects of both may be mediated by melatonin. To clarify melatonin's role in this process, we asked whether endogenous melatonin is required for rhythmic disk shedding in mouse retina. We analyzed disk shedding in two mouse strains: C3H, which produce melatonin in retina and pineal under the control of circadian oscillators, and C

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Repova, Kristina, Tomas Baka, Kristina Krajcirovicova, et al. "Melatonin as a Potential Approach to Anxiety Treatment." International Journal of Molecular Sciences 23, no. 24 (2022): 16187. http://dx.doi.org/10.3390/ijms232416187.

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Anxiety disorders are the most common mental diseases. Anxiety and the associated physical symptoms may disturb social and occupational life and increase the risk of somatic diseases. The pathophysiology of anxiety development is complex and involves alterations in stress hormone production, neurosignaling pathways or free radical production. The various manifestations of anxiety, its complex pathophysiological background and the side effects of available treatments underlie the quest for constantly seeking therapies for these conditions. Melatonin, an indolamine produced in the pineal gland a

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Balkhi, Shayan, Marie Saghaeian Jazi, Nader Mansour Samaei, Nahid Rezaie, and Mahtab Farahmandrad. "Serum Shock Enhances Endogenous Melatonin Production and Mitochondrial Gene Regulation in U87-MG Glioblastoma Cells." OBM Genetics 09, no. 03 (2025): 1–13. https://doi.org/10.21926/obm.genet.2503301.

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Glioblastoma (GBM) is the most aggressive primary brain tumor, with poor prognosis despite advancements in understanding its biology. Melatonin, a key regulator of metabolism and cellular homeostasis, is known for its neuroprotective and anti-cancer properties. While traditionally linked to pineal gland secretion, emerging evidence suggests that glioblastoma cells can produce melatonin within their mitochondria. This study investigates whether serum shock can influence endogenous melatonin production and mitochondrial gene expression in glioblastoma cells (U87-MG). U87-MG cells were subjected

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Cardenas-Padilla, Alberto Jorge, Francisco Jimenez-Trejo, Marco Cerbon, and Alfredo Medrano. "The Role of Melatonin on Caprine (Capra hircus) Sperm Freezability: A Review." Antioxidants 13, no. 12 (2024): 1466. http://dx.doi.org/10.3390/antiox13121466.

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In mammals, the pineal hormone melatonin is the most powerful pacemaker of the master circadian clock and is responsible for reproduction in seasonal breeders. It is also well known that melatonin and its metabolites play antioxidant roles in many tissues, including reproductive cells. Melatonin synthesis and secretion from the pineal gland occurs during scotophase (the dark phase during a day–night cycle), while its inhibition is observed during photophase (period of light during a day–night cycle). Short-day breeders, such as goats, are stimulated to breed in a manner dependent on high endog

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