Dissertations / Theses on the topic 'Endogenous models'
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Gaus, Eric. "Macroeconomic models with endogenous learning." Thesis, University of Oregon, 2010. http://hdl.handle.net/1794/10868.
Full textThe behavior of the macroeconomy and monetary policy is heavily influenced by expectations. Recent research has explored how minor changes in expectation formation can change the stability properties of a model. One common way to alter expectation formation involves agents' use of econometrics to form forecasting equations. Agents update their forecasts based on new information that arises as the economy progresses through time. In this way agents "learn" about the economy. Previous learning literature mostly focuses on agents using a fixed data size or increasing the amount of data they use. My research explores how agents might endogenously change the amount of data they use to update their forecast equations. My first chapter explores how an established endogenous learning algorithm, proposed by Marcet and Nicolini, may influence monetary policy decisions. Under rational expectations (RE) determinacy serves as the main criterion for favoring a model or monetary policy rule. A determinant model need not result in stability under an alternative expectation formation process called learning. Researchers appeal to stability under learning as a criterion for monetary policy rule selection. This chapter provides a cautionary tale for policy makers and reinforces the importance of the role of expectations. Simulations appear stable for a prolonged interval of time but may suddenly deviate from the RE solution. This exotic behavior exhibits significantly higher volatility relative to RE yet over long simulations remains true to the RE equilibrium. In the second chapter I address the effectiveness of endogenous gain learning algorithms in the presence of occasional structural breaks. Marcet and Nicolini's algorithm relies on agents reacting to forecast errors. I propose an alternative, which relies on agents using statistical information. The third chapter uses standard macroeconomic data to find out whether a model that has non-rational expectations can outperform RE. I answer this question affirmatively and explore what learning means to the economy. In addition, I conduct a Monte Carlo exercise to investigate whether a simple learning model does, empirically, imbed an RE model. While theoretically a very small constant gain implies RE, empirically learning creates bias in coefficient estimates.
Committee in charge: George Evans, Co-Chairperson, Economics; Jeremy Piger, Co-Chairperson, Economics; Shankha Chakraborty, Member, Economics; Sergio Koreisha, Outside Member, Decision Sciences
Pu, Junyi, and 浦俊懿. "Optimal procurement auctions with endogenous quantity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4322409X.
Full textJones, Charles I. (Charles Irving). "Time series tests of endogenous growth models." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/12701.
Full textTesoriere, Antonio. "Endogenous firm asymmetry vs symmetry in oligopoly models /." Louvain-la-Neuve : Univ. Catholique de Louvain, 2007. http://www.gbv.de/dms/zbw/54345987X.pdf.
Full textLazaris, Spyros M. "A study on endogenous growth models and trade." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-165642/.
Full textKim, Ji Uk. "Empirical tests of exogenous and endogenous growth models." Connect to resource, 1995. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1265037914.
Full textYin, Xiaopeng 1963. "Endogenous growth, international trade and dynamics." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37914.
Full textThe second essay turns to the Samuelson-Diamond overlapping generation paradigm, a finite-horizon overlapping generations model with education proposed by Michel (1993). The focus is shifted to the effect of trade on growth. It turns out that when trade affects the formation of human capital, endogenous growth is possible even in the simplest economy with a single sector and constant returns to scale technologies, which is opposite from Boldrin's (1992) and Jones and Manuelli's (1992) results.
While the existing theory of trade under oligopolistic competition is mostly static in nature, the third essay fills this gap by modeling international trade under oligopoly in a dynamic setting. This essay adopts the dynamics in the model provided by allowing the demand curve to shift over time as a result of "habit formation". It shows that when the importing country is committing to a policy of voluntary import expansions (VIEs), in the certain condition (i.e. k > 1), VIEs can improve the global welfare, the welfare of the importing country, and the profit of both firms. So, in a sense, voluntary import expansion is truly voluntary.
Peng, Baochun. "Entrepreneurship and economic growth." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270459.
Full textLazic, Stanley Edward. "Endogenous neural precursor cells in transgenic mouse models of neurodegenerative disorders." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613659.
Full textImura, Yuko. "Endogenous Trade Participation in Multi-Country Dynamic Stochastic General Equilibrium Models." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338303765.
Full textAbhayaratne, Anoma S. P. "Growth and international trade in developing countries : an empirical analysis." Thesis, University of Essex, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242227.
Full textYin, Xiaopeng 1963. "The effect of economic integration on endogenous economic growth." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23435.
Full textPoulsen, Odile. "Essays on determinacy and interdeterminacy in two-sector discrete time models." Thesis, University of Essex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340592.
Full textEmerson, Michael. "Endogenous nitric oxide and platelet function in in vivo models of thromboembolism." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300152.
Full textOlters, Jan-Peter. "Endogenous ballot decisions and "optimal" fluctuations : an economic model of politics." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36785.
Full textIn the absence of a "first-best," Pareto-optimal tax system, fiscal policies are implemented as a result of inter-household "conflicts" over tax rates and public spending. In order to be able to overcome the theoretical difficulties encountered in previous contributions to the Economic Theory of Politics, this text will propose a model that explicitly depicts---"democratically aggregated"---political decisions made on the level of every individual.
In this thesis, it will be shown that (i) a country's overall budget can be derived endogenously without relying on the theoretical shortcut of interpersonal preference aggregation, (ii) electoral fluctuations be explained on the basis of the changes to the individuals' particular income and wealth situations, (iii) political behaviour be described in terms of votes and abstentions as well as party membership and ideology, and (iv) the crucial importance of a country's wealth distribution be discussed in the context of economic stability and the role of government.
黃少軍 and Shaojun Huang. "Service sector development, structural change, and economic growth: international experriences and implicationsfor China." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31241815.
Full textFung, Lesley. "Investigations into the generation and control of endogenous erosion, using "in vitro" models /." Title page, summary and contents only, 1993. http://web4.library.adelaide.edu.au/theses/09DM/09dmf9812.pdf.
Full textApap, Robert M. "Models and Computational Strategies for Multistage Stochastic Programming under Endogenous and Exogenous Uncertainties." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/1002.
Full textDerin, Pinar. "Endogenous Growth Testing In The European Union And Developing Countries: Taxation, Public Expenditure And Growth." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/1112127/index.pdf.
Full textSchmidt, Gordon 1946. "Dynamics of endogenous economic growth theory and related issues : a case study of the "Romer model"." Monash University, Dept. of Economics, 2001. http://arrow.monash.edu.au/hdl/1959.1/8832.
Full textLi, Dajin. "Investment rate and economic growth in the long run, empirical tests of endogenous growth models." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32340.pdf.
Full textJamieson, Alec. "Assessment of fibrinolytic and antithrombotic activity resulting from modulation of endogenous fibrinolysis in animal models." Thesis, University of Aberdeen, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358267.
Full textJordan, Rhonda LeNai. "Incorporating endogenous demand dynamics into long-term capacity expansion power system models for Developing countries." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79547.
Full textPage 163 blank. Cataloged from PDF version of thesis.
Includes bibliographical references (p. 129-137).
This research develops a novel approach to long-term power system capacity expansion planning for developing countries by incorporating endogenous demand dynamics resulting from social processes of technology adoption. Conventional capacity expansion models assume exogenous demand growth; however, literature suggests that this assumption is not appropriate for developing countries. The planning approach presented in this research explicitly represents the links between the social and technical components of the power system. As potential customers without electricity select between various supply options to meet their power needs and as existing customers alter their consumption in reaction to the price of electricity and the perceived performance of the grid, the demand for grid power is directly impacted. This thesis demonstrates that neglecting these feedbacks and resorting to simplified assumptions can result in suboptimal investment strategies. By comparing the investment strategies identified using this novel approach to that of more conventional approaches, this research highlights cases in which the incorporation of endogenous demand impacts capacity expansion planning. More specifically, this work proves that incorporating endogenous electricity demand is important when there is a large fraction of the population without access to power or when the improvement in reliability afforded by capacity expansion is large. Employing traditional capacity expansion methods in such cases may lead to the selection of inferior expansion strategies. This research has both academic and applied contributions. Methodologically, this research extends state-of-the-art power system models by combining two generally separate modeling approaches, system dynamics and optimization. These methods are integrated to capture both the technical details of power grid operation and endogenous electricity demand dynamics in order to simulate the performance and evolution of the electric power grid. This research also demonstrates a holistic approach to centralized power planning that enables a more realistic representation of grid demand in developing countries and the identification of strategies that, in some cases, perform better than the strategies identified using traditional approaches. Finally, while this research was inspired by the case of Tanzania, the approach was developed with the flexibility to be applied to other countries with similar power system structure and contextual features.
by Rhonda LeNai Jordan.
Ph.D.
Fujiwara, Ippei. "Three essays on dynamic general equilibrium models." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:b963d031-cd68-4bee-91b7-4541e5d600d2.
Full textPredoiu, Silviu Nicolae. "Optimal Execution in a General One-Sided Limit-Order Book and Endogenous Dynamic Completeness of Financial Models." Research Showcase @ CMU, 2011. http://repository.cmu.edu/dissertations/115.
Full textShi, Wei. "Essays on Spatial Panel Data Models with Common Factors." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461300292.
Full textRega, M. "Investigation of endogenous chemical exchange saturation transfer effects with magnetic resonance imaging in various animal models of neurological disorders." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1463928/.
Full textPfister, Alexander. "Heterogeneous trade intervals in an agent based financial market." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/658/1/document.pdf.
Full textSeries: Working Papers SFB "Adaptive Information Systems and Modelling in Economics and Management Science"
Chen, Yougui. "Endogenous Phenolics from Expeller-pressed Canola Oil Refining Byproducts: Evaluation of Antioxidant Activities in Cell Culture and Deep-fat Frying Models." Journal of agricultural and food chemistry, 2014. http://hdl.handle.net/1993/30357.
Full textYe, Xin. "Development of models for understanding causal relationships among activity and travel variables." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001842.
Full textIwai, Nobuyuki. "Economic models of developing countries in the global ecnomy." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1063840190.
Full textTirok, Katrin. "Predator-prey dynamics under the influence of exogenous and endogenous regulation : a data-based modeling study on spring plankton with respect to climate change." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/2452/.
Full textEine der großen Herausforderungen der heutigen ökologischen Forschung ist es, Veränderungen von Ökosystemen vorherzusagen, die mit dem Klimawandel einhergehen. Dafür sind ein umfassendes Verständnis der verschiedenen Steuerungsfaktoren des entsprechenden Systems und Kenntnisse zur Anpassungsfähigkeit des Systems nötig. Auf der Grundlage dieses Wissens, können mit mathematischen Modellen Klimaszenarien gerechnet und Vorhersagen erstellt werden. Die vorliegende Arbeit untersuchte die Regulation des Phytoplanktons (kleine freischwebende einzellige Algen) und seiner Konsumenten (Zooplankton, tierische Kleinstlebewesen) sowie deren Wechselspiel während des Frühjahrs mit Bezug auf den Klimawandel. Als Basis dienten langjährige Daten von einem großen tiefen See (Bodensee) sowie Daten von Versuchen mit Organismen aus einem flachen marinen Gewässer (Kieler Förde, Ostsee). Diese Daten wurden mit statistischen Verfahren und mathematischen Modellen ausgewertet. In Gewässern sind Algen als Primärproduzenten die Nahrungsgrundlage für tierische Organismen bis hin zu Fischen und Meeresfrüchten, und bestimmen die Wasserqualität der Gewässer. Daher ist es wichtig zu verstehen, welche Mechanismen die Dynamik der Algen steuern. Der Grundstein für die saisonale Entwicklung von Phyto- und Zooplankton in Gewässern unserer Breiten wird mit dem Beginn des Wachstums im Frühjahr gelegt. Diese Arbeit zeigt, dass es bereits im zeitigen, noch kalten Frühjahr ein Wechselspiel physikalischer und biologischer Steuerungsmechanismen für die Algenentwicklung gibt. Physikalische Faktoren sind die Wassertemperatur, die Globalstrahlung und die Durchmischung des Gewässers, die durch die Stärke des Windes beeinflusst wird. All diese Steuerungsmechanismen sind eng miteinander verwoben und werden unterschiedlich stark vom Klimawandel beeinflusst. Mit mathematischen Modellen gelang es den Einfluss einzelner Faktoren voneinander zu trennen und zu zeigen, dass Effekte durch den Klimawandel sich gegenseitig aufheben oder aber auch verstärken können. Schon geringe Änderungen an der Basis der Nahrungsnetze können weitreichende Auswirkungen auf höhere Ebenen habe. Wie stark diese Auswirkungen im Einzelnen sind, hängt entscheidend von der Anpassungsfähigkeit gesamter Ökosysteme und ihrer Artengemeinschaften sowie einzelner Individuen ab. Beispielsweise reagiert die Algengemeinschaft auf einen starken Fraßdruck ihrer Räuber mit einer Verschiebung zu weniger gut fressbaren Algenarten. Diese weniger gut fressbaren Arten unterscheiden sich jedoch auch in anderen Eigenschaften, wie zum Beispiel der Ressourcenausnutzung, von besser fressbaren Algen. In dieser Arbeit wurden Modellansätze entwickelt, die diese Fähigkeit zur Anpassung berücksichtigen. Auf dieser Grundlage und mit Einbeziehung der physikalischen Steuerungsfaktoren können Klimaszenarien gerechnet werden und Vorhersagen für den Einfluss des Klimawandels auf unsere Gewässer gemacht werden, die letztlich auch Perspektiven für Handlungsmöglichkeiten aufzeigen.
Schlegel, Christoph. "Business Cycle Models with Embodied Technological Change and Poisson Shocks." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1099472232718-69586.
Full textSchlegel, Christoph. "Business Cycle Models with Embodied Technological Change and Poisson Shocks." Doctoral thesis, Technische Universität Dresden, 2003. https://tud.qucosa.de/id/qucosa%3A24392.
Full textTautvaišaitė, Šarūnė. "Periferinių regionų struktūrinių pokyčių valdymas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070816_153234-83924.
Full textResearch object - rural municipalities of Lithuania. Research subject - social – economical development of rural municipalities. Research aim - to compose the possibilities for peripheral areas structural changes management. Objectives: 1. To analyze specific of areas development and periphery in the theoretical aspects. 2. To compose methodic of peripherality evaluation and adapt it in practice. 3. To analyze specific of Lithuanian structural changes and their management. 4. To compose a structural changes management model of peripheral municipalities. Research methods: comparative, logical analysis and synthesis, analysis of both: data systematizing and statistical data, graphical depiction and modeling, correlation.
Anputhas, Markandu. "Simulating land use change for assessing future dynamics of land and water resources." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/56181.
Full textGraduate Studies, College of (Okanagan)
Graduate
Faustino, Rui Alexandre Rodrigues Veloso. "Essays in macroeconomics." Doctoral thesis, Instituto Superior de Economia e Gestão, 2020. http://hdl.handle.net/10400.5/20576.
Full textThis thesis has as its object of study the way consumer preferences affect structure and market power, measured through the markups of the firms that compete in it. By modifying the way consumer preferences are defined, it is possible to generate endogenous markups that significantly alter the responses of macroeconomic variables generated by different shocks. The thesis consists of three essays, the first of which analyzes the dynamics of markups in durable and nondurable consumption over the economic cycle and their response to shocks. For this, I take a New Keynesian model with durable goods and modified to include the habit formation at both types of goods. Depending on how the habit formation over durable consumption is defined, the model is able to replicate the responses of consumption variables, markups and prices observed in the data.The second essay deals with the effort made by consumers to compare prices between various sellers over the economic cycle. From microdata for the US, it is shown that increases in individuals’ hourly compensation translate into reductions in time spent comparing prices. From this, a mechanism is presented to generate countercyclical responses of the time spent in price comparison by consumers. When incorporated into general equilibrium models, this mechanism is capable of generating an amplifying effect on the responses of the main macroeconomic variables. Finally, a general equilibrium model is presented where the number of firms, varieties and quality of the consumed products are determined endogenously. Through the model, it is possible to analyze the dynamics of product creation and destruction, as well as the changes in their quality during the economic cycle, and their impact on the dynamics of the main macroeconomic variables.
Esta tese tem como objeto de estudo a forma como as preferências dos consumidores afetam a estrutura e o poder de mercado, medido através de markups, das empresas que nele concorrem. Modificando a forma como são definidas as preferências dos consumidores, é possível gerar markups endógenos e alterar significativamente as respostas de variáveis macroeconómicas a diferentes choques. A tese é composta por três ensaios, sendo que no primeiro são analisadas as dinâmicas dos markups nos bens de consumo duradouros e não duradouros ao longo do ciclo económico e a sua resposta a choques. Para isso, é apresentado um modelo Novo-Keynesiano com bens duradouros e não duradouros, modificado de forma a incluir a formação de hábitos nos dois tipos de bens. Dependendo da forma como é definida a formação de hábitos de consumo de bens duradouros, o modelo permite replicar as respostas observadas para o consumo, markups e preços. O segundo ensaio aborda o esforço despendido pelos consumidores na comparação de preços ao longo do ciclo económico. Partindo de microdados para os EUA, demonstro que aumentos da remuneração horária dos indivíduos traduzem-se em reduções no tempo despendido na comparação de preços. Em seguida, é apresentado um mecanismo capaz de gerar respostas contracíclicas do tempo despendido pelos consumidores na comparação de preços. Quando incorporado em modelos DSGE, é capaz de gerar um efeito amplificador das repostas das principais variáveis dos modelos. Por fim, é apresentado um modelo DSGE onde o número de empresas e a qualidade dos produtos consumidos são determinados de forma endógena. Através do modelo, é possível analisar as dinâmicas de criação e destruição de variedades, bem como das variações na sua qualidade durante o ciclo económico, e o seu impacto na dinâmica das principais variáveis macroeconómicas.
info:eu-repo/semantics/publishedVersion
CHRITY, DANIEL. "A SEQUENTIAL MODEL OF ENDOGENOUS COLLATERAL." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2004. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5165@1.
Full textEste trabalho desenvolve e estabelece a existência de equilíbrio para um modelo sequencial com dois estágios, mercados financeiros incompletos, risco de crédito e colateral endógeno. No primeiro estágio, ao escolherem o colateral, de acordo com uma regra exogenamente determinada, os agentes emitem ativos personalizados que serão transacionados no segundo estágio, em uma economia Walrasiana com dois períodos. A nossa estrutura permite o surgimento de modelos nos quais os próprios agentes escolhem suas garantias, de forma similar aos modelos já existentes de colateral endógeno. Tais modelos exibem o que podemos chamar de A Maldição do Vencedor, situação na qual o agente escolhe, racionalmente, oferecer colateral nulo, inviabilizando, em equilíbrio, a transação de ativos. Com isso, a economia é jogada para um equilíbrio Pareto inferior no qual não existem mercados financeiros. Ao introduzir uma sequencialidade nas escolhas, conseguimos resolver esse problema, pois os agentes antecipam o efeito da escolha de colateral sobre os payoffs de equilíbrio, escolhendo, racionalmente, colaterais positivos. Assim, conseguimos não somente solucionar uma limitação dos modelos existentes, como ainda, permitir o surgimento de inúmeros sub-modelos através das diversas possibilidades para a regra de escolha na determinação do colateral.
This paper develops and establishes the existence of equilibrium for a sequential model with two stages, incomplete financial markets, credit risk and endogenous collateral. In the first stage, by choosing the collateral, according to a predetermined and exogenously given rule, the agents issue personalized securities that will be traded in the second stage in aWalrasian economy with two periods. Our structure allows for models in which the agents choose their own collateral, similar to the existing endogenous collateral models. Those models exhibit what we might call, The Winner s Curse, a situation in which the agent choose, rationally, to offer no collateral, making asset trading impossible, in equilibrium. The economy is then thrown in a Paretoinferior equilibria in which there are no financial markets. By introducing the agent s choice in a sequential fashion, we avoid such a problem, because the agents anticipate the effects of their collateral choice over the equilibrium payoffs, therefore choosing rationally, positive collateral. That way, we are able, not only to solve a shortcoming of the existing models, but also to allow for a variety of sub-models through the several possible choices for the collateral determining rule.
Zhang, Xuelin. "An endogenous search model and its applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25912.pdf.
Full textRessler, Valerie T. (Valerie Terynn). "Endogenous and chemical modifications of model proteins." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121784.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 220-236).
Protein modifications are ubiquitous in nature, introducing biological complexity and functional diversity. Of the known post-translational modifications, glycosylation is one of the most common and most complex, yet some of the biological implications of this modification remain poorly understood. The development of chemical tools to mimic these modifications is helping to elucidate their biological roles and improve the range of biopharmaceuticals. To probe the biochemistry of endogenous glycosylation and to test the efficacy of novel synthetic modifications, tractable protein scaffolds are needed. Previously, members of the pancreatic-type ribonuclease (ptRNases) superfamily have been utilized as model protein scaffolds. They are a class of highly conserved, secretory endoribonucleases that mediate diverse biological functions through the cleavage of RNA.
The prototypical family homolog, human ribonuclease 1 (RNase 1), has been observed as a differentially glycosylated protein in vivo and been shown to tolerate a wide range of chemical manipulations. It has also emerged as an ideal candidate for protein-based drug therapy. The goal of this thesis is to showcase the biological potential of RNase 1 as a model endogenously glycosylated protein and as a protein payload for evaluating intracellular delivery systems. In CHAPTER 1, I summarize the current knowledge about ptRNases including their biochemical characterization, conservation of N-glycosylation, and therapeutic potential. RNase 1 possesses three N-glycosylation sites giving rise to enormous heterogeneity in biological samples, with unknown implications. In CHAPTER 2, I demonstrate that glycosylation of RNase 1 enhances protein stability and attenuates enzymatic activity.
In CHAPTER 3, I utilize a previously developed diazo compound to enhance delivery of a therapeutically relevant RNase 1 variant. The modification is shown to be reversed upon entry into the cell, presenting a novel approach for delivering native, functional proteins to the cytosol. Intracellular delivery of another model protein, Cytochrome C (CytoC), has shown therapeutic promise as well. In CHAPTER 4, I demonstrate that synthetic glycosylation with a large, monofunctionalized dextran conveys CytoC into the intracellular space, triggering apoptosis. Finally, CHAPTER 5 outlines future directions for the study of RNase 1 glycosylation and expanding the utility of the established diazo and dextran-based delivery systems. Taken together, this thesis explores a wide variety of protein modifications, demonstrating biochemical effects of endogenous glycosylation and enhanced delivery of protein payloads with chemical tools.
by Valerie T. Ressler.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Chemistry
Koutchade, Obafèmi-Philippe. "Hétérogénéité inobservée et solutions en coin dans les modèles micro-économétriques de choix de production multiculture." Thesis, Rennes, Agrocampus Ouest, 2018. http://www.theses.fr/2018NSARE048/document.
Full textIn this thesis, we are interested in questions of unobserved heterogeneity and corner solutions in acreage choice models. To answer these questions, we rely on a NMNL acreage share multi-crop models, of which we propose extensions. These extensions lead to specific estimation problems, to which we provide solutions.The question of unobserved heterogeneity is dealt with by considering a random parameter specification. This allows us to take into account the effects of the unobserved heterogeneity on all the parameters of the model. We show that the stochastic versions of the EM algorithm are particularly suitable for estimating this type of modelOur estimation and simulation results show that farmers react heterogeneously to economic incentives and that ignoring this heterogeneity can lead to biased simulated effects of public policies.In order to take account of the corner solutions in acreage choices, we propose modelling based on endogenous regime switching models with regime fixed costs. Unlike approaches based on censored regression systems, our model is “fully” consistent from a micro-economic viewpoint. Our results show that the regime fixed costs play an important role in farmers’ choice to produce or not some crops and they are, in the short term, an important determinant of acreage choices
Weng, Huibin. "A Social Interaction Model with Endogenous Network Formation." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin159317152899108.
Full textRagacs, Christian, and Martin Zagler. "Economic policy in a model of endogenous growth." Inst. für Volkswirtschaftstheorie und -politik, WU Vienna University of Economics and Business, 1997. http://epub.wu.ac.at/1154/1/document.pdf.
Full textSeries: Department of Economics Working Paper Series
Cortes, Francisco O’Neill. "An endogenous business cycle model : theory and simulation." Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/12830.
Full textEsta dissertação tem como objectivos principais, partindo dos modelos de ciclos económicos endógenos existentes na literatura, em primeiro lugar construir um novo modelo e em segundo lugar determinar a sua capacidade para gerar ciclos e em que medida os valores dos parâmetros afectam os resultados. O modelo-base que foi usado foi o modelo da capacidade utilizada de Leão (2016), complementado com o modelo "profit squeeze" de Sherman (1991). Depois de terem sido feitas simulações usando, tanto quanto possível, valores plausíveis para os parâmetros, concluiu-se que o modelo é de facto capaz de gerar ciclos económicos que satisfazem a maior parte dos factos estilizados e cuja forma depende dos parâmetros. Contudo, fica por fazer a estimação dos parâmetros do modelo para situações económicas concretas. Em suma, os resultados obtidos sugerem que a resposta do investimento a desvios da capacidade utilizada face ao seu valor desejável, o principal mecanismo em que o modelo se baseia, tem um papel relevante na explicação de como os ciclos económicos se desenrolam em economias reais.
This dissertation has as its main objectives, taking the models for endogenous business cycles existing in the literature, firstly to build a new model and secondly to determine its actual capability to generate cycles and how different parameter values can change the results. The base model used was the capacity utilization model by Leão (2016), complemented with the profit squeeze model by Sherman (1991). After we had run simulations using, as much as possible, plausible values for the parameters, it was found that the model can indeed generate business cycles that satisfy most stylized facts and whose shape depends on the parameters. However, the next step of estimating the parameters of the model for concrete real world situations remains still to be done. Overall, our results suggest that the response of investment to deviations of capacity utilization from its desirable level, which is the main mechanism on which the model is based, plays a significant role in the explanation of how business cycles develop in real economies.
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Schumacher, Ingmar. "Endogenous preferences, technical change and sustainability /." Louvain-la-Neuve : Univ. Catholique de Louvain, 2007. http://www.gbv.de/dms/zbw/560234562.pdf.
Full textPenna, Christiano Modesto. "Crescimento econÃmico via investimentos em capital: evidencias empÃricas para o Brasil." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1394.
Full textIn this work it is evident that a not linear relation exists enters the tax of rude formation of capital fixture and the tax of economic growth in Brazilian economy e, which had to this non linearity, the test of predictions of model AK and neoclÃssico considered for Jones (1995) starts to be inconclusivo, therefore exists space for the predictions of both the models. Our econometrical model indicates that, theoretically, the productivity delinquent of the capital if modifies a tax of growth in accordance with indicated for the parameter threshold. This modification can pparently be explained due to modification of the coefficient of elasticity of substitution between capital and work, being here a proposal of new inquiries. When dealing with public politics, one evidences that, no matter how hard if extends the tax of rude formation of capital fixture will arrive, in the maximum, to âcatch-upâ of the growth of the GIP of the economies of average income decrease and of the economic growth of the countries of the Asian east and the Pacific. The work also suggests that the sum of resources necessary to conclude such âcatch-upsâ is of the order of R$ 786 billion.
Yoon, Jung Eun. "Misallocation in a Model with Endogenous Managerial Capital and Distortions." Thesis, Princeton University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10281311.
Full textAggregate total factor productivity (TFP) differences across countries have been widely recognized as the primary source of huge divergence in per capita income across countries. The misallocation literature has found distortions that inefficiently allocate resources across production units can result in a significant aggregate productivity loss, even without deterioration in the underlying productivity distribution. However, with endogenous managerial capital investment decisions, distortions affect the underlying productivity distribution in addition to reallocating resources across production units.
The first chapter quantifies the effect of progressive taxation in a model with endogenous managerial capital investment decisions. Compared to proportional taxation that raises the same tax revenue, progressive taxation distorts the economy more severely. The more progressive is taxation, the less incentive agents have to invest in their managerial capital. This follows because higher managerial capital implies higher profit, which induces higher tax rates. Thus, compared to a proportional tax regime that raises the same tax revenue, under progressive taxation, agents invest less in their managerial capital and the distribution of income is less dispersed. In addition, the equilibrium values of TFP, total output, employment share of large firms are distorted relative to their values under proportional taxation. Hence, progressive taxation improves equality in the economy in exchange for efficiency.
In the second chapter I examine the effects of credit constraint in a model with endogenous managerial capital investment decisions. If agents can optimally invest in their managerial capital, limited access to physical capital will encourage managers to substitute away from physical capital to investment in managerial capital. The accumulation of managerial capital and the change in the underlying productivity distribution will mitigate the adverse effects of misallocation caused by the credit constraint on the economy. Using calibration, I show that measured TFP could improve with a tighter credit constraint.
The third chapter adds stochastic component to the model with endogenous managerial capital investment decision and credit constraints. I find that with sufficiently large second moment shock to the managerial skill accumulation function, the mitigation effect induced by optimal managerial capital investment decision is itself mitigated.
Schmidt, Gordon W. "Dynamics of endogenous economic growth : a case study of the "Romer model" /." Amsterdam [u.a.] : Elsevier, 2003. http://www.loc.gov/catdir/enhancements/fy0614/2003043910-d.html.
Full textSchmidt, Peter. "Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3942.
Full textLeSage, James P., and Manfred M. Fischer. "Spatial Regression-Based Model Specifications for Exogenous and Endogenous Spatial Interaction." WU Vienna University of Economics and Business, 2014. http://epub.wu.ac.at/4271/1/SSRN%2Did2420746.pdf.
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