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Dissertations / Theses on the topic 'Endogenous neural stem cells'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Horky, Laura L. "Fate of endogenous neural stem/progenitor cells following spinal cord injury in the adult mammal /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112823.

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2

Grapensparr, Liza. "Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327314.

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Type 1 diabetes develops through the progressive destruction of the insulin-producing beta-cells. Regeneration or replacement of beta-cells is therefore needed to restore normal glucose homeostasis. Presently, normoglycemia can be achieved by the transplantation of whole pancreas or isolated islets of Langerhans. Islet transplantation can be performed through a simple laparoscopic procedure, but the long-term graft survival is low due to poor revascularization and early cell death. This thesis examined the possibility of using different auxiliary cells (Schwann cells, endothelial progenitor ce
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3

Nikolakopoulou, Polyxeni [Verfasser], Andreas [Gutachter] Androutsellis-Theotokis, Andreas [Akademischer Betreuer] Androutsellis-Theotokis, and Henning [Gutachter] Morawietz. "The role of endogenous neural stem cells (eNSCs) in metabolic syndrome and aging / Polyxeni Nikolakopoulou ; Gutachter: Andreas Androutsellis-Theotokis, Henning Morawietz ; Betreuer: Andreas Androutsellis-Theotokis." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1226898416/34.

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4

Nikolakopoulou, Polyxeni [Verfasser], Andreas [Gutachter] Androutsellis-Theotokis, Andreas Akademischer Betreuer] Androutsellis-Theotokis, and Henning [Gutachter] [Morawietz. "The role of endogenous neural stem cells (eNSCs) in metabolic syndrome and aging / Polyxeni Nikolakopoulou ; Gutachter: Andreas Androutsellis-Theotokis, Henning Morawietz ; Betreuer: Andreas Androutsellis-Theotokis." Dresden : Technische Universität Dresden, 2019. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa2-334852.

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5

Marshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.
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6

Eriksson, Malin. "Manipulating neural stem cells." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-853-2/.

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7

Hall, P. E. "Integrins and neural stem cells." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599860.

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Extracellular matrix (ECM)-rich basal laminae are an important component of other stem cell niches and thus are likely to form part of the NSC niche. Interactions with the ECM are mediated manly by cell surface heterodimers called integrins. β1 integrins have been implicated in maintaining human epidermal stem cells, and their elevated expression has allowed the enrichment of human prostate epithelial stem cells from transit amplifying populations. My work has focused on the role of the ECM and its receptors in the mammalian CNS stem cell niche. Initial experiments examined the conditions nece
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8

Noisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes
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9

Wong, Wing-ki Shirley. "Survival pattern of transplanted stem cells /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31494377.

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10

Wong, Wing-ki Shirley, and 黃穎琪. "Survival pattern of transplanted stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010481.

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11

Waldhuber, Markus. "Neural stem cells in development and cancer." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-92214.

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12

Joannides, Alexis. "Neural differentiation of human embryonic stem cells." Thesis, University of Cambridge, 2009. https://www.repository.cam.ac.uk/handle/1810/252121.

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Human embryonic stem cells (hESCs) are a potential source of defined cell types for studying early human development and application in regenerative medicine. Realising this potential requires a number of challenges to be overcome. The experimental findings reported represent a systematic approach in establishing controlled and standardised conditions for differentiating hESCs down the neural lineage, and characterising neural derivatives both <i>in vitro</i> and <i>in vivo.</i> Human embryonic stem cell cultures were established from two independently-derived liens, H9 and UES9. A novel, effi
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13

Enarsson, Mia. "Roles of PDGF for Neural Stem Cells." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4245.

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14

Cassady, John P. "Transdifferentiation of fibroblasts to neural stem cells." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/83634.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>The developmental process is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogr
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15

Tommei, Diva. "Transcriptional characterization of glioma neural stem cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608138.

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16

Albertson, Roger Joseph. "Establishing asymmetry in Drosophila neural stem cells /." view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3112998.

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Thesis (Ph. D.)--University of Oregon, 2003.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 101-117). Also available for download via the World Wide Web; free to University of Oregon users.
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17

Ng, Yuen Ling. "Novel reactors for aggregative neural stem cells and yeast cells." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613068.

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18

Gomes, Cátia Sofia Vicente. "Cues for cancer stem cells origin." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/12439.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Neural stem/progenitor cells (NSPC) can differentiate into neurons and glial cells in the central nervous system. Interestingly, NSPC biology is being applied to the study of human brain tumours, since these cells share some common features with glioma cells. However, it is not known the developmental stage with more similarities to glioma cells, or the most susceptible to malignant transformation. We aimed to identify the stage(s) in the NSPC differentiation process towards astrocytes where cells acquire phen
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19

Johansson, Clas B. "Isolation and characterization of adult neural stem cells /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-104-7/.

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20

Ringstedt, Thomas. "Neurotrophins during development : overexpression in neural stem cells /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980605ring.

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21

Pan, Chendong. "Neural differentiation from human embryonal carcinoma stem cells." Thesis, Durham University, 2007. http://etheses.dur.ac.uk/2460/.

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It is understood that retinoic acid (RA), sonic hedgehog (Shh) and bone morphogenic proteins (BMPs) play an important role in cell fate determination and the specification of inter-neurons and motor neurons along the dorsal-ventral axis in the neural tube. In this study, we investigated the function of these signalling molecules to instruct the differentiation of human pluripotent stem cells to form specific neuronal subtypes. TERA2.cl.SP12 embryonal carcinoma (EC) cells are a robust caricature of human embryogenesis and an accepted model of neural differentiation. Gene and protein expression
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22

Perfect, Leo. "Monoallelic gene expression in human neural stem cells." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/monoallelic-gene-expression-in-human-neural-stem-cells(9df001b2-7a7d-4e17-a9a0-d21c27927686).html.

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Monoallelic expression is when only one of a gene’s two copies is transcribed. It has long been recognised in the form of X-chromosome inactivation, genomic imprinting and random monoallelic expression (RME) of a small number of gene families. More recently, studies have reported evidence of widespread autosomal RME in human lymphoblastoid cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression in human neural stem cells, I
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23

Kennea, Nigel Leonard. "Neural differentiation of human fetal mesenchymal stem cells." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7409.

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The potential of mesenchymal stem cells (MSC) to differentiate into neural lineages has raised the possibility of autologous cell transplantation as therapy for neurological diseases. There are, however, no studies reporting significant numbers of oligodendrocytes, the myelinforming cells of the central nervous system, derived from MSC. We have recently identified a population of circulating human fetal MSC that are highly proliferative and readily differentiate into bone, cartilage, fat and muscle. I demonstrated for the first time that primary fetal MSC differentiate into cells resemblifl ne
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24

Liao, Jinxin Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Investigation of endogenous stem cells and reactive astrocytes in post-traumatic syringomyelia." Awarded by:University of New South Wales. Clinical School - Prince of Wales Hospital, 2007. http://handle.unsw.edu.au/1959.4/40674.

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Introduction: Around a quarter of patients with spinal cord injury develop post traumatic syringomyelia (PTS), causing progressive neurological deficits. Current surgical treatment is unsatisfactory. Endogenous stem cell therapy, aiming at replacing lost tissue and repairing damaged ones by endogenous progenitors, may offer hope. Investigation into the reaction of endogenous progenitors in PTS may extend our knowledge about stem cell biology and help to develop a new treatment option for PTS. Endogenous stem cells were found to differentiate into astrocytes. Reactive astrocytes and gliosis are
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25

Snethen, Heidi. "The role of endogenous stem cells in spontaneous repair in multiple sclerosis." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558200.

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Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). It is multifactorial with a multitude of neurological presentations. Equally there is a plethora of treatments for MS. Many offer relief from symptoms and reduce the number of relapses in the early phase of disease, but to date none have been shown to halt or slow disease progression. Recently the use of stem cell transplantation has been explored as a therapy for MS. Preliminary results are promising, but without knowledge of endogenous neural progenitor cells (NPC) within the CNS, and their
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26

Eastlake, K. "Investigation of factors that prevent endogenous retinal regeneration by Müller stem cells." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1493351/.

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In fish and amphibians, Müller glia are able to promote regeneration of the retina throughout adult life. Although these cells are present in the adult human retina, there is no evidence to suggest that regeneration in humans occurs following disease or injury. In Vitro, a population of human Müller glia has been described as possessing stem cell characteristics with the ability to proliferate and differentiate towards a neural phenotype. This may suggest that factors may be lost from the local retinal environment in the adult eye or that endogenous factors released during retinal disease ma
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27

Lazic, Stanley Edward. "Endogenous neural precursor cells in transgenic mouse models of neurodegenerative disorders." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613659.

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28

Pierret, Chris. "Characterization of an in vitro neural stem cell niche with educational component Stem cells and society /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6054.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 3, 2009) Vita. Includes bibliographical references.
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29

Johansson, Amica. "Temporal regulation of neural stem cells during cortex development." Thesis, KTH, Skolan för bioteknologi (BIO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215288.

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30

Danilov, Alexandre I. "Neurogenesis, neural stem cells and nitric oxide in neuroinflammation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-484-8/.

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31

Hardy, Steven Allan. "Mesenchymal stem cells as trophic mediators of neural differentiation." Thesis, Durham University, 2010. http://etheses.dur.ac.uk/524/.

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Intense excitement and optimism surrounds the rapidly-expanding field of stem cell research, owing to their high capacity for self-renewal and intrinsic ability to differentiate into mature cell lineages. Although it may be envisioned that embryonic stem cells will be of significantly greater therapeutic value than their adult stem cell counterparts, the use of embryonic stem cells is fraught with both technical and ethical challenges and, as such, significant impetus has been placed on adult stem cell-based research. In particular, mesenchymal stem cells (MSCs) present as exciting candidates
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32

Reisenberg, Melina. "Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells". Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/diacylglycerol-lipasedependent-endocannabinoid-signaling-in-neural-stem-cells(19317ce6-b568-465d-a1de-540cb3392712).html.

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The diacylglycerol lipases (DAGL α and β) synthesise 2-AG, the major endocannabinoid (eCB) in the developing and adult brain. 2-AG acts most prominently on the CB1 and CB2 receptors and growing evidence points to a role of eCB signaling in adult neurogenesis as well as a wide range of different physiological roles in the brain. The focus of this thesis is on DAGL driven eCB signaling in neural stem cells (NSC). A role of the eCB system has previously been established in migration, proliferation, and neurogenesis. Here we investigated DAGLα and eCB signaling in the context of differentiation. T
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33

Sun, Yirui. "Neural stem (NS) cells, from mouse, rat, and human." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/11436.

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Neural stem cells are the self-renewing and oligopotent cell population that generate constituent cell types of the nervous system. Cultured neural stem cells would offer researchers accessible opportunities to answer fundamental questions in both neurodevelopment and cell biology. Current strategies of maintaining neural stem/progenitor cells in vitro largely rely on neurosphere cultures (Reynolds and Weiss, 1992) and/or genetic immortalization (Frederiksen et al., 1988; Sah et al., 1997), These approaches raise concerns about cellular heterogeneity and potential cell transformation. Our lab
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34

Hemmati, Houman David Rothenberg Ellen V. "Neural stem and progenitor cells in cancer and development /." Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-05232006-140457.

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35

Robins, Sarah. "Neural stem/progenitor cells in the adult mouse hypothalamus." Thesis, University of Sheffield, 2009. http://etheses.whiterose.ac.uk/111/.

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Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem cells resides in the hypothalamus, more specifically in the ependymal lining of the third ventricle. In this thesis, I tested the hypothesis that stem cells exist in defined regions of the adult mouse hypothalamus. My work confirms the presence of stem/progenitor cells in the adult mouse hypothalamus. An
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36

Wimmer, Ryszard. "Migration of neural stem cells during human neocortical development." Electronic Thesis or Diss., Université Paris sciences et lettres, 2024. http://www.theses.fr/2024UPSLS016.

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Chez les espèces gyrencéphaliques, et en particulier chez l'homme, la forte augmentation de la taille du néocortex est largement soutenue par une niche neurogénique élargie, la zone sous-ventriculaire externe (oSVZ). Cela est dû en grande partie à l'amplification d'une population de cellules souches neurales, les cellules gliales radiales basales (bRG, également appelées oRG). Les cellules bRG colonisent la zone sous-ventriculaire externe grâce à un mouvement dépendant de l'acto-myosine appelé translocation somale mitotique (MST). Le mécanisme moléculaire exact de la MST, la question de savoir
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37

Vicario, Nunzio. "Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4088.

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Despite the remarkable beneficial effects of disease-modifying agents in relapsing-remitting multiple sclerosis (MS) patients, progressive forms of (P)MS still lack effective treatments. This stark contrast is partially dependent on the difficulties researchers have found in tackling the complex pathophysiology of this phase of disease, in which chronic inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immun
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38

Ngamjariyawat, Anongnad. "The beneficial Effects of Neural Crest Stem Cells on Pancreatic β–cells". Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233157.

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Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. The work presented in this thesis aimed to study the roles of neural crest stem cells or their derivatives in supporting β-cell proliferation, function, and survival. In co-culture when mouse boundary cap neural crest stem cells (bNCSCs) and pancreatic islets were in direct contact, differentiating bNCSCs st
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39

Wiskow, Ole. "Evaluation of the neuronal differentiation capacity of pluripotent stem cells and neural stem cells in monolayer culture." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609417.

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40

Munir, Hafsa. "Mesenchymal stem cells as endogenous regulators of leukocyte recruitment : the effects of differentiation." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6471/.

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Mesenchymal stem cells (MSC) are a tissue-resident stromal cell population that are able to regulate immune responses, in particular the capacity for endothelial cells (EC) to support leukocyte recruitment. In this thesis we examined the ability of MSC from different sources (bone marrow, Wharton’s jelly and trabecular bone) to regulate neutrophil recruitment to inflamed EC and how these responses are altered upon adipogenic differentiation of MSC. Using two flow based adhesion models with varying degrees of proximity between MSC and EC, we observed that all MSC populations suppressed neutroph
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41

Armiento, Angela Rita. "Investigating endogenous mesenchymal stem cells to understand their role in articular cartilage repair." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228555.

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Articular cartilage is an extraordinary tissue, allowing frictionless movements of articulated joints, and acting as a load-bearing cushion to protect joints from damage. Breakdown of articular cartilage may result in crippling diseases such as osteoarthritis (OA) and, since articular cartilage has a limited repair capacity, a greater understanding of the mechanisms of joint homeostasis and its response to injury are of great clinical need. In this project the hypothesis that endogenous mesenchymal stem cells (MSCs) may contribute to the healing process of a full-thickness articular cartilage
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42

O'Keeffe, Gráinne Catherine. "The effect of dopamine on endogenous neural precursor cells in Parkinson's Disease." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612288.

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43

Erlandsson, Anna. "Neural Stem Cell Differentiation and Migration." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3546.

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Malandraki-Miller, Sophia. "Enhancing progenitor cells for cell therapy after myocardial infarction." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:205043f4-e3e0-4947-9afc-b43f1543e0bd.

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Based on data from the World Healthcare Organisation, cardiovascular diseases are the primary cause of disease-related death globally, with myocardial infarction (MI) being the most prevalent. If not treated effectively, MI can progress to heart failure (HF). With 70 million prescriptions for HF in 2014 and 515 people in the UK being hospitalised daily with MI, the British Heart Foundation calls for novel robust treatments. Even though cardiac stem cell (CSC) therapy for MI has been under investigation for more than a decade, there still has not been a consensus over the identity of the adult
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Hack, Michael Anton. "Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-38718.

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46

Åkerud, Peter. "GDNF family ligands and neural stem cells in Parkinson's disease /." Stockholm : [Karolinska Univ. Press], 2001. http://diss.kib.ki.se/2001/91-7349-042-3/.

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47

Jones, Robert. "Proteomic analysis of neural differentiation in mouse embryonic stem cells." Thesis, Bangor University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412699.

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48

McLaren, Fiona Henderson. "A characterisation of MHC expression by rat neural stem cells." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621899.

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49

Hui, Man-ning, and 許文寧. "Investigating the role of SOX9 in human neural stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193481.

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Neural stem cells (NSCs) exist in both embryonic and adult neural tissues and are characterized by their self-renewal capacity and multipotency that contribute to the generation of three major cell types in the vertebrate central nervous system (CNS):neurons, oligodendrocytes and astrocytes. The tremendous therapeutic potential of NSCs to treat the neurodegenerative diseases and repair brain injuries has provoked intensive study in the molecular regulation of their induction, maintenance and differentiation. Previous study reported that Sox9, a member of high-mobility-group(HMG) containing
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50

Dawes, William John. "Neural stem cells as therapeutic targets in germinal matrix haemorrhage." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24869.

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Haemorrhage within the germinal matrix with extension into the ventricle is commonly seen in very low birth weight babies. Outcome following severe haemorrhage, in particular when associated with post haemorrhagic hydrocephalus and congestive venous infarction is poor, whilst outcome following moderate degrees of haemorrhage remains variable. The Neural Stem Progenitor Cells (NSPC) within the GM have been shown to be exquisitely sensitive to micro-environmental cues, as such, haemorrhage within the GM is postulated to impact on neurological outcome through aberration of normal NSPC behaviour.
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