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Dissertations / Theses on the topic 'Endogenous opioids'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Ghule, Aishwarya [Verfasser]. "The importance of endogenous opioids in feeding behavior / Aishwarya Ghule." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1183093942/34.

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2

Stagg, Nicola Jane. "Reversal of Neuropathic Pain with Exercise is Mediated by Endogenous Opioids." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194833.

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Exercise is often prescribed for patients with chronic pain, but there is little objective evidence supporting this recommendation. Therefore, we tested the effect of moderate aerobic exercise on the sensory hypersensitivity produced in an animal model of neuropathic pain. Male rats that underwent unilateral ligation of the L5 and L6 spinal nerves (SNL) were divided into exercise-trained or sedentary groups. Exercise training was performed using a treadmill, beginning 7 days after surgery, and continued 5 days a week for 5 weeks. Animals were exercised 30 min/day, at a speed of 14-16 m/mi

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3

Robinson, Kathleen Clare. "Cutaneous Biology and Endogenous Opioids: How the Skin Modulates Pain and Addiction." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11215.

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The Proopiomelanocortin gene, (POMC), produces many biologically active peptides including the endogenous opioid, β-endorphin, and the melanocortins: α-Melanocyte Stimulating Hormone, (αMSH), γMSH, βMSH and Adrenocorticotropic Hormone, (ACTH). βendorphin is released by the brain in response to stress or injury and is a potent analgesic. Melanocortins are well known for regulating pigmentation, metabolism, and cortisol levels. Additionally, opioids and melanocortins are known to have opposing actions in several settings including the regulation of pain and met

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4

au, Ash_Frew@yahoo com, and Ashley Kim Frew. "The influence of discouragement, anxiety and anger on pain: An examination of the role of endogenous opioids." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050930.111852.

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Animal research suggests that exposure to inescapable stressors can lead to an endogenous opioid-mediated form of pain inhibition, known as stress-induced analgesia (SIA). Similar results have been found with humans, although the literature is much less extensive and at times contradictory where uncontrollable stressors have led to an increase, rather than a decrease in pain. More recently, there has been some suggestion that emotions play an important role in pain modulation, and that particular negative moods are associated with opioid-mediated hypoalgesia. This research aimed to clarify the

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5

Gustafsson, Lisa. "Endogenous Opioids and Voluntary Ethanol Drinking : Consequences of Postnatal Environmental Influences in Rats." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7776.

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6

Daoura, Loudin. "Early Environment and Adolescent Ethanol Consumption : Effects on Endogenous Opioids and Behaviour in Rats." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198670.

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Excessive and compulsive ethanol drinking is one of the most serious public health issues. Therefore, it is vital to increase the knowledge about risks and protection for alcohol use disorders (AUD) to optimize prevention and treatment strategies. Ethanol consumption commonly initiates during adolescence when extensive neuronal maturation and development also occurs. Early exposure to ethanol is a risk factor for AUD, but the effects of adolescent drinking and the basis for the individual susceptibility to AUD are not fully understood. The interactions between genotype and environmental factor

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7

Olson, Keith Mathew, and Keith Mathew Olson. "Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626669.

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Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effective treatment for chronic pain patients. These studies explore three pre-clinical strategies to improve MOR analgesia and minimize side effects: 1) compounds that target G-protein Coupled Receptors (GPCRs) heterodimers, such as heterodimerization between the Delta Opioid Receptor (DOR) and MOR (MDOR); 2) multi-functional compounds that target multiple receptor systems for synergistic effects, such as a MOR agonist and a the serotonin reuptake transporter (SERT) inhibitor; or 3) biased agonists

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8

Schwellnus, Martin Peter. "The role of the endogenous opioid system in thermoregulation during exercise." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27169.

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In man the metabolic heat produced during physical exercise stresses the thermoregulatory system, particularly if hot, humid environmental conditions prevail. It has recently been postulated that endogenous opioids may play a role in regulating body temperature at rest and because it has also been shown that blood levels of these substances increase during exercise, the possibility exists that endogenous opioids may play a role in thermoregulation during exercise. A study was conducted in two parts to determine the thermoregulatory response during exercise with and without pharmacologic blocka

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9

Frew, Ashley. "The influence of discouragement, anxiety and anger on pain : an examination of the role of endogenous opioids /." Access via Murdoch University Digital Theses Project, 2004. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050930.111852.

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10

Frew, Ashley Kim. "The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids." Thesis, Frew, Ashley Kim (2005) The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids. PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/55/.

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Animal research suggests that exposure to inescapable stressors can lead to an endogenous opioid-mediated form of pain inhibition, known as stress-induced analgesia (SIA). Similar results have been found with humans, although the literature is much less extensive and at times contradictory where uncontrollable stressors have led to an increase, rather than a decrease in pain. More recently, there has been some suggestion that emotions play an important role in pain modulation, and that particular negative moods are associated with opioid-mediated hypoalgesia. This research aimed to clarify the

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11

Frew, Ashley Kim. "The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids." Frew, Ashley Kim (2005) The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/55/.

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Animal research suggests that exposure to inescapable stressors can lead to an endogenous opioid-mediated form of pain inhibition, known as stress-induced analgesia (SIA). Similar results have been found with humans, although the literature is much less extensive and at times contradictory where uncontrollable stressors have led to an increase, rather than a decrease in pain. More recently, there has been some suggestion that emotions play an important role in pain modulation, and that particular negative moods are associated with opioid-mediated hypoalgesia. This research aimed to clarify the

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12

Nadal, i. Roura Xavier 1980. "Participation of the endogenous opioid and cannabinoid systems in neuropathic pain." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/81782.

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This work is focused in the study of the pathophysiology of neuropathic pain, particularly in the role of the endogenous opioid and cannabinoid systems. Neuropathic pain is a chronic illness with a high prevalence in the population and is characterized by the presence of spontaneous pain and abnormal stimulus-evoked pain responses, among other symptoms. It is a clinical pain manifestation that has shown to be poorly treated with the available pharmacological treatment. Even with the existence of many therapeutic approaches, there is not an adequate effective treatment for palliating all sympto

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13

Herman, Melissa Ann. "GABA signaling in the nucleus tractus solitarius (NTS) central control of gastric motility and modulation by endogenous opioids /." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/642326159/viewonline.

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14

Yilmaz, Bayram. "The role of endogenous opioids and brain neurotransmitters in the generation of the LH surge in the rat." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360282.

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15

Johnson, David W. "Regulation and site of action of exogenous and endogenous opioids on growth hormone and prolactin secretion in Holstein calves." Diss., Virginia Tech, 1990. http://hdl.handle.net/10919/39812.

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Four studies were conducted to investigate the effect and site of action of exogenous and endogenous opioids on pituitary growth hormone (GH) and prolactin (PRL) secretion in Holstein calves. In the first study, the effect of the opioid agonist DAMME (D-Ala²⁺,N-Me-Phe⁴,Met(O)⁵-01 enkephalin) on plasma GH and PRL secretion was measured in Holstein calves in fall season. Plasma concentrations of both GH and PRL increased in response to DAM ME injection. Pretreatment with either the lipid soluble opioid antagonist naloxone (NAL), which readily penetrates the blood brain barrier (BBB), or the peri

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16

Wood, Malcolm S. "Characterization of opioid binding sites in spinal cord and other tissues." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/25215.

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The binding of [³H]opioid ligands to homogenates prepared from the spinal cords of rat and other species has been studied. Similar numbers of sites were seen in all areas of the cord when measured in a rostrocaudal direction. There was found to be approximately 2 x higher density of sites in the dorsal half of the cord compared with the ventral half. Binding studies suggested a similar relative distribution of mu, delta and kappa sites in all areas of the cord. The results are discussed in relation to the reported distribution of opioid peptides. In the above study the kappa binding site was d

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17

Alteryd, Olivia. "Think your pain away : The neurochemistry of placebo analgesia." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17615.

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Placebo treatments are inert but are known to alleviate symptoms across numerous clinical conditions. One of the most studied placebo effects is placebo analgesia, which is a placebo effect limited to pain relief. This thesis aims to introduce the current state of research regarding the neuroscience of placebo analgesia and specifically to present research findings regarding the neurotransmission. Studies have demonstrated that placebo analgesia can be elicited through two separate processes interacting with each other; manipulation of expectations and through conditioning. These processes see

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18

Mohamed, Esraa M. "ENDOGENOUS OPIOID PEPTIDES AND BRAIN DEVELOPMENT: ENDOMORPHIN-1 AND NOCICEPTIN PLAY A SEX-SPECIFIC ROLE IN THE CONTROL OF OLIGODENDROCYTE MATURATION AND BRAIN MYELINATION." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5984.

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Myelin is an extensive cell membrane produced by oligodendrocytes to ensheath neuronal axons in the central nervous system with the primary goal of maximizing the efficiency of electrochemical impulse transmission. During brain development, oligodendrocytes differentiate into myelin forming cells in a tightly regulated process which makes them vulnerable to multiple insults. Previous results from the laboratory showed that the timing of oligodendrocyte differentiation and rat brain myelination were altered by perinatal exposure to buprenorphine and methadone, opioid analogues used for treating

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19

Bennett, Ryan. "Association Tests of the Opioid Receptor System and Alcohol-Related Traits." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1993.

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The opioid receptors and their endogenous ligands have long been implicated in a variety of traits including addiction, impulsive behaviors and substance dependence. Using phenotypic measurements collected from the IASPSAD, data from a latent class analysis and data from a SNP array and additional genotyping assays, association and regression tests were performed to determine the effects of common SNPs encoded in the genes of the opioid receptors and ligands on various traits relating to alcohol dependence. Although only one SNP can be reported as significant for substance dependence within

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20

Crisanti, Kim Carolyn. "Adenosine, not the endogenous opioids, mediates the regulated decrease in core temperature that occurs in both newborn and older guinea pigs during acute hypoxemia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ31339.pdf.

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21

Hara, Yuko. "Dopamine-dependent plasticity and subcellular locations of dopamine D1 receptors : in relation to glutamate NMDA receptors and endogenous opioids in the nucleus accumbens, implications for schizophrenia /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528441261&sid=22&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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22

LaPrairie, Jamie L. "The Impact of Neonatal Inflammatory Insult on Adult Somatosensory Processing: The Role of the Descending Nociceptive Circuit." Atlanta, Ga. : Georgia State University, 2008. http://digitalarchive.gsu.edu/biology_diss/42/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from title page (Digital Archive@GSU, viewed June 16, 2010) Anne Z. Murphy, committee chair; Timothy Bartness, Matthew Grober, Michael Gold, Charles Derby, committee members. Includes bibliographical references (p. 148-164).

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23

Lee, Ying-siu Andrew, and 李應紹. "Endogenous opioid peptides and cardiac arrhythmias." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B31231275.

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24

Lee, Ying-siu Andrew. "Endogenous opioid peptides and cardiac arrhythmias /." [Hong Kong] : University of Hong Kong, 1988. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12358812.

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25

Rebouças, Elce Cristina Côrtes. "Envolvimento de receptores opióides e serotoninérgicos nos processos antinociceptivos induzidos por substância doce." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-10112006-091759/.

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Bases: A antinocicepção induzida por substâncias doces tem sido largamente estudada. Contudo, a investigação dos neurotransmissores envolvidos nesse processo antinociceptivo ainda carece de mais estudos, pois é de extrema importância entender o envolvimento desses neurotransmissores no sistema neural que controla este tipo de antinocicepção. Objetivo: O objetivo deste estudo é clarificar o envolvimento dos sistemas opióide e serotoninérgico na antinocicepção induzida por substância doce. Método: O presente trabalho foi realizado em modelo animal (Rattus norvegicus, Rodentia, Muridae), objetiva

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26

Ramesh, Divya. "Elevating Endogenous Cannabinoids Reduces Opioid Withdrawal in Mice." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2661.

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Delta9-tetrahydrocannbinol (THC), the primary active constituent of Cannabis sativa, has long been known to reduce opioid withdrawal symptoms. Although THC produces most of its pharmacological actions through the activation of CB1 and CB2 cannabinoid receptors, the role these receptors play in reducing opioid withdrawal symptoms remains unknown. The endogenous cannabinoids, N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonylglycerol (2-AG), activate both cannabinoid receptors, but are rapidly metabolized by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respec

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27

Nogueira, Thereza Christina Monteiro de Lima. "Estresse e convulsões: participação dos opioides endogenos." reponame:Repositório Institucional da UFSC, 1989. http://repositorio.ufsc.br/xmlui/handle/123456789/75592.

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Tese (doutorado) - Universidade de São Paulo. Departamento de Fisiologia e Biofisica<br>Made available in DSpace on 2012-10-16T02:39:44Z (GMT). No. of bitstreams: 0Bitstream added on 2013-07-16T17:11:53Z : No. of bitstreams: 1 79070.pdf: 3225953 bytes, checksum: ea81b1737299aba3fa4afaa0e98c7d30 (MD5)

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28

ZHANG, SHENGWEN. "THE OPIOID RECEPTOR-LIKE RECEPTOR ORL1: SIGNALING AND INTERACTION WITH OPIOID RECEPTORS." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1029419843.

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29

Finn, Anja. "Methods and detection of endogenous peptides in the CNS and GI tract /." Stockholm : Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-991-2/.

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30

Lazega, David. "Opioid binding properties after environmental, pharmacological and genetical changes of the endogenous opioid system /." Zürich, 1987. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8365.

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31

Palm, Sara. "Early Environment, Adolescent Alcohol Drinking and Neurobiological Responses to Drugs." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229992.

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Genes and environment interact to determine an individual’s vulnerability or resilience to several psychiatric disorders, including alcohol use disorder (AUD). Alcohol use is often initiated during adolescence and early onset drinking is associated with increased risk for later AUD. Childhood and adolescence are periods of extensive brain maturation, which makes young individuals more susceptible to environmental influence. However, little is known about early environmental influence on reward pathways and behaviors involved in the development of AUD. Changes in the endogenous opioid and dopam

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32

Brooks, A. N. "Endogenous opioid modulation of luteinizing hormone secretion in the ewe." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370347.

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33

FORADORI, CHAD D. "THE ROLE OF ENDOGENOUS OPIOID PEPTIDES IN THE OVINE ESTROUS CYCLE." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061305407.

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34

Patel, Dinesh. "Structural and pharmacological studies of synthetic and endogenous opioid receptor ligands." Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/11073.

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The interaction of a diverse set of opioid alkaloids and peptides with various opioid receptors has been examined using biochemical and pharmacological techniques. Structural information on the compounds was obtained from single crystal X-ray diffraction and nuclear magnetic resonance studies, and modelled by computational methods. The introduction of a dithiocarbazate moiety into the 7a-position of a bridged thebaine was shown to afford a degree of μ selectivity in this class of nonselective compounds. X-ray diffraction analysis of this compound and comparison with the structure of [Met5]enke

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35

McCarthy, Michael J. "Regulation of the endogenous opioid system by acute nicotine and nicotine withdrawal." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1076018422.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 172 p.; also includes graphics (some col.). Includes bibliographical references (p. 131-172 ). Available online via OhioLINK's ETD Center

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36

Oldroyd, Keith G. "The pathophysiological role of the endogenous opioid system in myocardial ischaemia and cardiac failure." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260270.

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The endogenous opioid system may be involved in the pathogenesis of arrhythmias and produce deleterious haemodynamic effects in patients with myocardial ischaemia and/or cardiac failure. Plasma concentrations of β-endorphin, a potent opioid peptide, were elevated in 31/42 patients with acute myocardial infarction, 3/18 with unstable angina, 3/34 with chronic heart failure, 8/28 with acute heart failure and 10/14 with cardiogenic shock. (Met)enkephalin levels were generally normal. There was no independent statistical relationship between β-endorphin concentrations after myocardial infarction a

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37

Mathes, Wendy Foulds. "Running wheel activity attenuates the effects of exogenous opiates : implications for the endogenous opioid system /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2000.

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Thesis (Ph.D)--Tufts University, 2000.<br>Adviser: Robin B. Kanarek. Submitted to the Dept. of Psychology. Includes bibliographical references (leaves 109-134). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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38

Mancino, Samantha 1987. "Involvement of the endogenous opioid and cannabinoid systems in addictive like-behaviours." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565773.

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The increase incidence of obesity and eating disorders represents a major health problem in developed countries. The low rate of success of treatments to prevent or reverse obesity, and overeating that causes it, highlights the important behavioural alterations that are associated to this disease. These alterations seem to be mediated by modifications in the reward circuits that mimic changes occurring during addictive behaviour. Moreover, like drugs of abuse, obesity is associated with abnormal intake habits when maintaining diet that can endure vulnerability to relapse. In the present thesis

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39

Hussain, Muhammad Zubair. "Molecular Adaptations in the Endogenous Opioid System in Human and Rodent Brain." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205133.

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The aims of the thesis were to examine i) whether the endogenous opioid system (EOS) is lateralized in human brain areas involved in processing of emotions and pain; ii) whether EOS responses to unilateral brain injury depend on side of lesion, and iii) whether in human alcoholics, this system is involved in molecular adaptations in brain areas relevant for cognitive control of addictive behavior and habit formation. The main findings were that (1) opioid peptides but not opioid receptors and classic neurotransmitters are markedly lateralized in the anterior cingulate cortex involved in proces

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40

Marinelli, Peter W. "The interaction of alcohol with endogenous opioid peptides in the rat brain /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85581.

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Alcohol abuse and addiction are among the most costly and prevalent behavioural disorders due to the drug's reinforcing potential and ubiquity in society. Studies suggest an interaction between alcohol and the endogenous opioid system: manipulation of endogenous opioid activity affects alcohol intake, and alcohol administration alters endogenous opioid activity. However, the data are inconclusive given the discrepancy between pharmacological and genetic knockout studies on alcohol intake, and the difficulty in interpreting and replicating findings determined postmortem.<br>There were tw

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41

Burattini, Costanza <1977&gt. "Role of the endogenous opioid system in addiction to alcohol and cocaine." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/444/.

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42

Shabir, Saima. "Endogenous opioid receptors and peptides : involvement in food intake and reward processes." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312581.

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43

Escudero, Lara Alejandra 1992. "Targeting endogenous analgesia systems for endometriosis treatment." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671695.

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Endometriosis is a chronic inflammatory disease that affects 1 in 10 women of childbearing age. It is characterized by the growth of endometrium in extrauterine locations and is associated with chronic pelvic pain, infertility, emotional distress and loss of working ability. Current clinical management provides unsatisfactory outcomes. Thus, the development of more effective therapeutic strategies is still an unmet clinical need, and their development relies on the establishment of animal models that recapitulate the features of endometriosis. The present Thesis has characterized a surgical mo

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44

Lara, Mayorga Itzel Montserrat 1982. "Effects of behavioural traits and the endogenous opioid system in neuropathic pain manifestations." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/663848.

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Neuropathic pain is a complex disorder that includes nociceptive, emotional and cognitive manifestations. This work was focused on how inter-individual variability and endogenous opioid system may be associated with these manifestations. For this purpose, we first validated behavioural paradigms to measure the emotional and cognitive manifestations. Then, we evaluated the influence of specific behavioural traits as well as the role of preproenkephalin (Penk) on neuropathic pain manifestations. We found that time-dependent consequences of neuropathic pain were detected by classical paradigms to

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45

Bell, Katrina Margaret. "A biochemical and pharmacological characterisation of some endogenous and exogenous κ opioid ligands". Thesis, Loughborough University, 1994. https://dspace.lboro.ac.uk/2134/12053.

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An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.

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46

Davis, Brooke A. "The Role of Endogenous Opioid Peptides in the Regulation of Male Sexual Behavior." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1153327766.

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47

Vanderah, Todd William. "The direct and modulatory antinociceptive actions of endogenous and exogenous opioid delta agonists." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187190.

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Opioids are responsible for a number of effects but are employed primarily as analgesics. The discovery of endogenous opioids and multiple receptors have led to a better understanding of how analgesics function, and how both opioid receptors and endogenous ligands are regulated. The hypothesis of this dissertation states that levels of endogenous enkephalins are modulated by stress, inflammation and the endogenous peptide cholecystokinin (CCK) to alter the antinociceptive efficacy of μ and, possibly, δ opioids. Endogenous enkephalin release results in either direct antinociception or synergist

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48

Corder, Gregory F. "INJURY ESTABLISHES CONSTITUTIVE µ-OPIOID RECEPTOR ACTIVITY LEADING TO LASTING ENDOGENOUS ANALGESIA AND DEPENDENCE." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/10.

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Injury causes increased pain sensation in humans and animals but the mechanisms underlying the emergence of persistent pathological pain states, which arise in the absence of on-going physical damage, are unclear. Therefore, elucidating the physiological regulation of such intractable pain is of exceptional biomedical importance. It is well known that endogenous activation of µ-opioid receptors (MORs) provides relief from acute pain but the consequences of prolonged endogenous opioidergic signaling have not been considered. Here we test the hypothesis that the intrinsic mechanisms of MOR signa

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McQuilken, Shona A. "An immunohistochemical investigation of the endogenous opioid system in healthy and diseased human colon." Thesis, Glasgow Caledonian University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493926.

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Abstract:

Crohn's disease and ulcerative colitis (UC), two types of inflammatory bowel disease (IBD), and idiopathic slow transit constipation (ISTC) are serious diseases of the digestive system with unknown aetiologies. Since it is well known that opioids have a profound effect on the gastrointestinal tract, and also play an important role in immune regulation, it is postulated that they may be involved in the pathophysiology of these debilitating disorders. In this investigation immunohistochemical techniques were used to determine a potential role for opioids in intestinal disease by evaluating the a

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Wang, Ying [Verfasser], and Heike [Gutachter] Rittner. "Immune and peripheral endogenous opioid mechanisms of electroacupuncture analgesia / Ying Wang. Gutachter: Heike Rittner." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1111783217/34.

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