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Journal articles on the topic 'Endometrial cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Arai, Y., and M. Nishida. "Differential diagnosis between normal endometrium and endometrial hyperplasia with immunostaining cytology using anti-LeY monoclonal antibody." International Journal of Gynecologic Cancer 13, no. 1 (2003): 42–46. http://dx.doi.org/10.1136/ijgc-00009577-200301000-00008.

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We have previously reported that both endometrial cancer and endometrial hyperplasia stain positively for the anti-LeY monoclonal antibody, whereas normal endometrium does not. Endometrial hyperplasia is a premalignant change associated with the eventual development of endometrial carcinoma. However, it can be difficult to differentiate hyperplasia from normal endometrium in cytology. This study illustrates the use of immunocytochemical cytology using anti-LeY monoclonal antibody to differentiate between endometrial hyperplasia and normal endometrium. Immunostaining using anti-LeY monoclonal a

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2

Easo, Anu Sarah, Rajeev Anand, and Mini Issac. "Evaluation of apparent diffusion coefficient in endometrial carcinoma compared to normal endometrium: a retrospective study." International Journal of Research in Medical Sciences 9, no. 7 (2021): 2043. http://dx.doi.org/10.18203/2320-6012.ijrms20212356.

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Background: To determine whether diffusion-weighted imaging (DWI) with measurement of apparent diffusion coefficient (ADC) will help in differentiating endometrial cancer from normal endometrium and to determine whether the grades of endometrial cancer will show significant difference in ADC values.Methods: This is a retrospective study done in MOSC medical college hospital Kolencherry. on patients on whom preoperative MRI was done before hysterectomy. Cases from July 2017 to March 2021 were included. Study cases included 40 females with pathologically confirmed endometrial cancer and 30 femal

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3

Boyarskikh, Ulyana, Andrey Kechin, Evgeniy Khrapov, et al. "Detecting Microsatellite Instability in Endometrial, Colon, and Stomach Cancers Using Targeted NGS." Cancers 15, no. 20 (2023): 5065. http://dx.doi.org/10.3390/cancers15205065.

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Purpose: To develop a method for testing the MSI based on targeted NGS. Methods: Based on the results of previous studies, 81 microsatellite loci with high variability in MSI-H tumors were selected, and a method for calculating the MSI score was developed. Using the MSI score, we defined the MSI status in endometral (162), colon (153), and stomach (190) cancers. Accuracy of the MSI scores was evaluated by comparison with MMR immunohistochemistry for 137 endometrium (63 dMMR and 74 pMMR), 76 colon (29 dMMR and 47 pMMR), and 81 stomach (8 dMMR and 73 pMMR) cancers. Results: Classification of MSS

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4

Mokhtar, N. M., F. SA Saghir, A. Mohd Dali, I. Mohamed Rose, and A. A. Jamal. "409. Differentially expressed genes in endometroid endometrial carcinoma using microarray: a preliminary report." Reproduction, Fertility and Development 20, no. 9 (2008): 89. http://dx.doi.org/10.1071/srb08abs409.

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Background: Endometrial cancer is the commonest cancer among women in the western countries. It ranks the fourth in gynaecological cancers incidence in Malaysia. Endometriod carcinoma is the commonest subtype of endometrial cancer. The aetiology of this disease is still not fully understood. Previous theories have suggested the disease is caused by the activation of oncogenes and inactivation of the tumour suppressor genes. The aim of this study is to identify expressing genes involved in the endometrial carcinoma compared with the normal endometrium. Materials and Methods: All endometrial tis

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CAPLAKOVA, VERONIKA, EVA BABUSIKOVA, EVA BLAHOVCOVA, TOMAS BALHAREK, MARIA ZELIESKOVA, and JOZEF HATOK. "DNA Methylation Machinery in the Endometrium and Endometrial Cancer." Anticancer Research 36, no. 9 (2016): 4407–20. http://dx.doi.org/10.21873/anticanres.10984.

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6

Kodama, J., T. Kusumoto, N. Seki, et al. "Heparanase expression in both normal endometrium and endometrial cancer." International Journal of Gynecologic Cancer 16, no. 3 (2006): 1401–6. http://dx.doi.org/10.1136/ijgc-00009577-200605000-00069.

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The aim of this study was to investigate the relationship between heparanase expression and prognostic factors in endometrial cancer, as well as the relationship between heparanase expression during phases of the normal endometrial cycle. Immunohistochemical analysis of 166 endometrial cancers and 34 normal endometria in various phases of growth was performed. The heparanase expression in the late-proliferative phase of normal endometria was found to be significantly higher than in either the early-proliferative or the secretory phases (P = .012 and P = .044, respectively). Heparanase expressi

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7

MARUYAMA, A., T. SAITO, Y. HACHITANDA, and N. TSUKAMOTO. "Cancer history and loss of MSH2 and MLH1 protein expression in patients with endometrial hyperplasia." International Journal of Gynecologic Cancer 13, no. 3 (2003): 352–60. http://dx.doi.org/10.1136/ijgc-00009577-200305000-00015.

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In order to evaluate the hereditary background of endometrial hyperplasia patients in relation to protein expression of DNA mismatch repair genes, we evaluated 69 patients with endometrial hyperplasia and 18 patients with normal endometrium having both a personal and family history of cancer (two hereditary nonpolypoid colorectal cancer (HNPCC) patients). We obtained personal and family histories of cancer for all patients. MSH2 and MLH1 protein expression was investigated by immunohistochemical methods. In the endometrial hyperplasia patients, 11 had personal histories and 40 had family histo

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8

Rawat, Rajani, Soniya Vishwakarma, Shikha Seth, Vaibhav Kanti, and Pragati Mishra. "Clear Cell Carcinoma of Endometrium: A Clinical Review." Journal of SAFOMS 2, no. 1 (2014): 15–19. http://dx.doi.org/10.5005/jp-journals-10032-1026.

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ABSTRACT Clear cell carcinoma of endometrium is a rare (1-6%) but aggressive malignancy with high propensity of early extra-uterine spread. The usual presentation is postmenopausal bleeding and discharge as with other endometrial cancers but it does not have preceding hyperplastic stage, instead it develops from thin atrophic endometrium, therefore impossible to identify by the screening measures like Pap smear and transvaginal sonography. First step for early diagnosis of such unfavorable endometrial cancer should be endometrial biopsy. Histopathological diagnosis is mandatory to confirm the

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9

Mandic, Aljosa, and Tamara Vujkov. "Endometrial cancer: Diagnostic methods in postmenopausal vaginal bleeding." Archive of Oncology 11, no. 2 (2003): 97–101. http://dx.doi.org/10.2298/aoo0302097m.

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Postmenopausal vaginal bleeding (PMB) is the leading symptom of endometrial cancer. More than 70% of patients with endometrial cancer are postmenopausal. Despite PMB as a leading symptom in diagnosis of endometrial cancer, PMB could be caused by some benign processes in endometrium such as hyperplasia and focal endometrial disease, such as a polyp. The golden standard for histological evaluation of the endometrium is curettage. Transvaginal ultrasound (TVS) and measurement of endometrium thickness is also one of the favored methods in the last decade. Sonographic imaging of the endometrium can

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10

Boaventura, Camila Silva, José Lucas Scarpinetti Galvão, Giovanna Milanes Bego Soares, et al. "Synchronous gynecologic cancer and the use of imaging for diagnosis." Revista da Associação Médica Brasileira 62, no. 2 (2016): 116–19. http://dx.doi.org/10.1590/1806-9282.62.02.116.

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Summary Endometrial and cervical cancers are the most prevalent gynecologic neoplasms. While endometrial cancer occurs in older women, cervical cancer is more prevalente in young subjects. The most common clinical manifestation in these two gynecological cancers is vaginal bleeding. In the first case, diagnosis is made based on histological and imaging evaluation of the endometrium, while cervical cancers are diagnosed clinically, according to the International Federation of Gynecology and Obstetrics (FIGO). The authors present a case of synchronous gynecological cancer of the endometrium and

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11

Rusda, Muhammad, Andri Sipahutar, and Andrina Yunita Murni Rambe. "Application of International Endometrial Tumor Analysis in Abnormal Uterine Bleeding: A Case Report." Open Access Macedonian Journal of Medical Sciences 10, T7 (2022): 7–11. http://dx.doi.org/10.3889/oamjms.2022.9236.

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BACKGROUND: Abnormal uterine bleeding (AUB) is one of the clinical symptoms found in malignant conditions where the incidence of newly diagnosed cancers reached 100,000 cases in Europe in 2012 with an incidence of around 14.7/100,000 women. The International Endometrial Tumor Analysis (IETA) group, formed in Chicago in 2008, published a consensus stating how to examine and measure the endometrium. CASE REPORT: Mrs. M, 49 years old, came to Gynecology Clinic of USU Hospital on February 22, 2021, at 13.00 WIB with the complaints of prolonged menstruation for 2 months with a volume of >10 time

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Mladenovic-Segedi, Ljiljana, Milos Pantelic, and Dragan Stajic. "Endometrial carcinoma in asymptomatic postmenopausal women with a thickened endometrium." Medical review 75, no. 11-12 (2022): 333–37. http://dx.doi.org/10.2298/mpns2212333m.

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Introduction. The most common clinical manifestation of endometrial cancer is postmenopausal bleeding, as well as irregular uterine bleeding. Far less often, endometrial cancer may also be present in postmenopausal women without bleeding. The aim of our study was to examine the incidence of endometrial cancer in asymptomatic postmenopausal women with a thickened endometrium. Material and Methods. The research included 251 asymptomatic postmenopausal women with endometrial thickness over 4 mm established by ultrasound. Exploratory curettage was performed in all the patients, followed by histopa

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13

Abe, Naoya, Jun Watanabe, Shinpei Tsunoda, Hiroyuki Kuramoto, and Isao Okayasu. "Significance of Nuclear p-Akt in Endometrial Carcinogenesis: Rapid Translocation of p-Akt Into the Nucleus by Estrogen, Possibly Resulting in Inhibition of Apoptosis." International Journal of Gynecologic Cancer 21, no. 2 (2011): 194–202. http://dx.doi.org/10.1097/igc.0b013e318207964c.

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Introduction:Endometrial endometrioid adenocarcinoma (endometrial cancer) develops through endometrial hyperplasia caused by estrogenic hyperstimulation. Estrogen is known to activate growth factor signaling pathways, resulting in cellular proliferation, but precisely how has not been clarified. The aim of this study was to investigate the significance of estrogen and downstream factors such as the MAPK (MEK, ERK) and Akt pathways in endometrial carcinogenesis.Methods:The expression of p-MEK, p-ERK, and p-Akt was analyzed immunohistochemically in normal, hyperplastic, and neoplastic endometria

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14

Joshi, Narendra, Kalpesh Patel, Bhawani Shankar Sharma, Neeraj Choudhary, and Balveer Jakhar. "Prospective study of role of transvaginal sonography in postmenopausal bleeding and its histopathological correlation: a prospective study from a tertiary care hospital of Rajasthan." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 14, no. 4 (2025): 1235–43. https://doi.org/10.18203/2320-1770.ijrcog20250868.

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Postmenopausal bleeding is vaginal bleeding that occurring after one years of menopause. When periods have stopped for more than one years in women who are generally over than 45 years old and it is common condition in postmenopausal women, it can be the presenting symptom of endometrial cancer. Aim of study is to assess endometrial thickness by vaginal sonography and correlate it with the cytological pattern evaluated by endometrial sampling and histopathological typing of the endometrium. Methods: This is a prospective observational study conducted in department of obstetrics and gynaecology

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15

Pańczyszyn, Anna, Ewa Boniewska-Bernacka, Karolina Włodarczyk, Iwona Wertel, and Anna Goc. "Telomeres and telomerase in endometrial cancer and hyperplasia." Archives of Medical Science 20, no. 2 (2024): 682–85. http://dx.doi.org/10.5114/aoms/186189.

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IntroductionThe study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.Material and methodsTotal RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.ResultsThe control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.ConclusionsTelomere extension in endometria

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16

Dewi Anggraeni, Tricia, Raymond Surya, and Andrew Pratama Kurniawan. "Obesity and Endometrial Cancer: Mechanism and How to Deal with?" Cermin Dunia Kedokteran 48, no. 6 (2021): 343. http://dx.doi.org/10.55175/cdk.v48i6.1437.

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<p>Obesity is strongly associated with development of endometrial cancer more than any other cancer type. The relationship between obesity and endometrial cancer risk is combination of inflammation, insulin resistance, and increased bioavailability of estrogen. Obesity can increase risk to develop endometrial cancer as exogenous estrogen has impact for tumorigenesis. The best method to reduce the risk of endometrial cancer in obese women is through progesterone medication and lifestyle intervention.</p><p>Obesitas erat kaitannya dengan terjadinya kanker endometrium lebih dari

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17

KÖSE, Mesut, Ayhan VURMAZ, and Yasemin ÇELİK. "BENİGN, PRE-MALİGN VE MALİGN ENDOMETRİYAL LEZYONLARDA PROLİDAZ AKTİVİTESİ VE OKSİDATİF STRES." Kocatepe Tıp Dergisi 24, no. 2 (2023): 195–200. http://dx.doi.org/10.18229/kocatepetip.1105749.

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OBJECTIVE: The present study aims to investigate the prolidase activity, total oxidant status (TOS) and total anti-oxidant status (TAS) in women who have been diagnosed with benign, pre-malignant and malignant endometrial pathologies. MATERIAL AND METHODS: Ninety women who underwent endometrial biopsy due to abnormal uterine bleeding were divided into three groups according to their histopathological findings: Benign endometrial pathology (n=65), endometrial hyperplasia (n=12) and endometrial cancer (n=13). These groups were compared with respect to oxidative stress markers and prolidase activ

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Bennarij, Eman S., Mohamed A. El Tomey, Manal F. Hamisa, and Neveen S. A. I. Shaker. "Role of transvaginal ultrasound in the detection of endometrial changes in breast cancer patients under hormonal therapy." Tanta Medical Journal 53, no. 3 (2025): 324–33. https://doi.org/10.4103/tmj.tmj_96_23.

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Background Among female cancers, breast cancer was the second cause of death, behind only lung cancer. The purpose of this research was to assess transvaginal ultrasound’s (TVUS) utility in detecting endometrial abnormalities in hormone-treated breast cancer patients. Aim The study aimed to evaluate the role and efficacy of TVUS in the detection of endometrial changes in breast cancer patients under hormonal therapy. Patient and methods A total of 60 individuals undergoing adjuvant hormone treatment for breast cancer and probable endometrial abnormalities were included in this cross-sectional

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19

Ellinidi, Vera N., Elizaveta A. Smaglenko, Viktoria A. Pechenikova, Igor A. Samusenko, and Maxim V. Bunyakov. "Human leukocyte antigen, isotype DR (HLA-DR) expression in the normal endometrium and in endometrial pathology." Journal of obstetrics and women's diseases 73, no. 5 (2024): 96–104. https://doi.org/10.17816/jowd632930.

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BACKGROUND: Human leukocyte antigen, isotype DR (HLA-DR) expression is associated with inflammatory and autoimmune diseases. It is also found on the surface of tumor cells. The role of HLA-DR in endometrial pathology has not been sufficiently studied. AIM: The aim of this study was to determine HLA-DR expression features in the endometrium under normal and pathological conditions. MATERIALS AND METHODS: We performed immunohistochemical examination of endometrial biopsy specimens, namely, 18 cases of endometrioid carcinomas, 139 cases of chronic endometritis, and 37 cases of endometrial polyps.

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Bianchi, F., S. Rosati, L. Belvederesi, et al. "MSH2 splice site mutation and endometrial cancer." International Journal of Gynecologic Cancer 16, no. 3 (2006): 1419–23. http://dx.doi.org/10.1136/ijgc-00009577-200605000-00072.

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Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited syndrome of cancer susceptibility caused by germ line mutations of genes participating in mismatch repair (MMR). Carriers of MMR gene mutations have an increased risk of colorectal cancers and cancer of other organs. Tumors of the endometrium represent the most frequent extracolonic malignancies in HNPCC. It has been suggested that women harboring MMR gene mutations have a higher risk of endometrial cancer than of colon cancer. Here, we describe an HNPCC patient with early-onset endometrial cancer and a strong familial history o

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Degasper, Christine, Andrea Brunner, Natalie Sampson, et al. "NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer." Tumor Biology 41, no. 2 (2019): 101042831983000. http://dx.doi.org/10.1177/1010428319830002.

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The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. DNA methylation of the NOX4 promoter was determined by means of MethyLight PCR. Data were correlated with clinicopath

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Reske, Jake J., Mike R. Wilson, Jeanne Holladay, et al. "Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis." PLOS Genetics 17, no. 12 (2021): e1009986. http://dx.doi.org/10.1371/journal.pgen.1009986.

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TP53 and ARID1A are frequently mutated across cancer but rarely in the same primary tumor. Endometrial cancer has the highest TP53-ARID1A mutual exclusivity rate. However, the functional relationship between TP53 and ARID1A mutations in the endometrium has not been elucidated. We used genetically engineered mice and in vivo genomic approaches to discern both unique and overlapping roles of TP53 and ARID1A in the endometrium. TP53 loss with oncogenic PIK3CAH1047R in the endometrial epithelium results in features of endometrial hyperplasia, adenocarcinoma, and intraepithelial carcinoma. Mutant e

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Delforce, Sarah J., Eugenie R. Lumbers, Celine Corbisier de Meaultsart, et al. "Expression of renin–angiotensin system (RAS) components in endometrial cancer." Endocrine Connections 6, no. 1 (2017): 9–19. http://dx.doi.org/10.1530/ec-16-0082.

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A dysfunctional endometrial renin–angiotensin system (RAS) could aid the growth and spread of endometrial cancer. To determine if the RAS is altered in endometrial cancer, we measured RAS gene expression and protein levels in 30 human formalin-fixed, paraffin-embedded (FFPE) endometrioid carcinomas and their adjacent endometrium. All components of the RAS were expressed in most tumours and in adjacent endometrium; mRNA levels of (pro)renin receptor (ATP6AP2), angiotensin II type 1 receptor (AGTR1), angiotensin-converting enzyme (ACE1) and angiotensin-converting enzyme 2 (ACE2) mRNA levels were

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Kulinczak, Mariusz, Maria Sromek, Grzegorz Panek, et al. "Endometrial Cancer-Adjacent Tissues Express Higher Levels of Cancer-Promoting Genes than the Matched Tumors." Genes 13, no. 9 (2022): 1611. http://dx.doi.org/10.3390/genes13091611.

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Molecular alterations in tumor-adjacent tissues have recently been recognized in some types of cancer. This phenomenon has not been studied in endometrial cancer. We aimed to analyze the expression of genes associated with cancer progression and metabolism in primary endometrial cancer samples and the matched tumor-adjacent tissues and in the samples of endometria from cancer-free patients with uterine leiomyomas. Paired samples of tumor-adjacent tissues and primary tumors from 49 patients with endometrial cancer (EC), samples of endometrium from 25 patients with leiomyomas of the uterus, and

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Njoku, Kelechi, Amy E. Campbell, Bethany Geary, et al. "Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer." Cancers 13, no. 4 (2021): 718. http://dx.doi.org/10.3390/cancers13040718.

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Endometrial cancer is the most common malignancy of the female genital tract and a major cause of morbidity and mortality in women. Early detection is key to ensuring good outcomes but a lack of minimally invasive screening tools is a significant barrier. Most endometrial cancers are obesity-driven and develop in the context of severe metabolomic dysfunction. Blood-derived metabolites may therefore provide clinically relevant biomarkers for endometrial cancer detection. In this study, we analysed plasma samples of women with body mass index (BMI) ≥ 30 kg/m2 and endometrioid endometrial cancer

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Li, Xiao, Yiping Gao, Mingzi Tan, et al. "Expression of HE4 in Endometrial Cancer and Its Clinical Significance." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/437468.

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The main aims of this study were to determine the expression of human epididymis protein 4 (HE4) in endometrial cancer and to explore the relationships between HE4 expression, clinicopathological parameters, and prognosis. Immunohistochemistry was used to detect HE4 expression in 102 cases of endometrial cancer, 30 cases of endometrial atypical hyperplasia, and 20 cases of normal endometrium. The positive expression rate of HE4 in endometrial carcinoma was 84.62%, significantly higher than 66.67% in atypical hyperplasia (P<0.05) and 15.00% in normal endometrium (P<0.0.01). With the excep

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Jongen, V. H. W. M., J. H. H. Thijssen, H. Hollema, et al. "Is aromatase cytochrome P450 involved in the pathogenesis of endometrioid endometrial cancer?" International Journal of Gynecologic Cancer 15, no. 3 (2005): 529–36. http://dx.doi.org/10.1136/ijgc-00009577-200505000-00019.

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Prospectively, the relationship between androgen levels in the utero-ovarian circulation, aromatase activity in endometrial and body fat tissue, and the presence or absence of endometrioid endometrial cancer was studied in postmenopausal women. In 43 women with endometrioid endometrial cancer and 8 women with a benign gynecological condition, a hysterectomy with bilateral salpingo-oophorectomy was performed. Using tritium water-release assays, aromatase activities in endometrial and body fat tissue were determined and related to the steroid levels from the peripheral and the utero-ovarian veno

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Sharma, D., N. K. Saxena, P. M. Vertino, and F. A. Anania. "Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways." Endocrine-Related Cancer 13, no. 2 (2006): 629–40. http://dx.doi.org/10.1677/erc.1.01169.

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An increase in the risk of cancer is one of the consequences of obesity. The predominant cancers associated with obesity have a hormonal basis and include breast, prostate, endometrium, colon and gall-bladder cancers. Leptin, the key player in the regulation of energy balance and body weight control also acts as a growth factor on certain organs in both normal and disease states. Therefore, it is plausible that leptin acts to promote cancer growth by acting as a mitogenic agent. However, a direct role for leptin in endometrial cancer has not been demonstrated. In this study, we analyzed the pr

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Lee, Suk-young. "Tailored Therapy Based on Molecular Characteristics in Endometrial Cancer." BioMed Research International 2021 (May 5, 2021): 1–11. http://dx.doi.org/10.1155/2021/2068023.

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Management of endometrial cancer, an adenocarcinoma of the endometrium which occupies most uterine corpus neoplasms, including uterine sarcomas, has been more relevant due to its increasing incidence. Extensive research on tumorigenesis molecular mechanisms and molecular characterization across cancers has brought paradigm shifts in the treatment of various malignant tumors. Endometrial cancer treatment has been traditionally guided according to the disease extent or histology types, while recent studies on molecular features have led to the introduction of targeted agents into clinical use, a

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Jabłoński, Krzysztof, Łukasz Kurek, Maciej Żukowski, et al. "Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem." Journal of Clinical Medicine 9, no. 12 (2020): 3870. http://dx.doi.org/10.3390/jcm9123870.

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Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen re

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Ulrikh, Elena Aleksandrovna, Dzhamilat Ilyasovna Khalimbekova, Adiliya Fettekhovna Urmancheyeva, Dmitriy Yevgenyevich Matsko, and Vakhtang Mikhaylovich Merabishvili. "Mesonephric (clear cell) endometrial cancer." Journal of obstetrics and women's diseases 61, no. 5 (2012): 85–91. http://dx.doi.org/10.17816/jowd61585-91.

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Clear Cell Endometrial Cancer is a rare nonendometrioid endometrial carcinoma detected in 1–6 %. The aim of the study was to determine clinical and morphologic features of Clear Cell Endometrial Cancer. Materials: All the cases with Clear Cell Endometrial Cancer treated in the N. N. Petrov Research Institute of Oncology (Saint-Petersburg) were identified from surgical pathology files from 1985 to 2010 years. Saint-Petersburg Population Cancer Registry data (2000–2005 years period) and N. N. Petrov Research Institute of Oncology Hospital Cancer Registry data (1985–2010 years period) were analyz

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Putra, Very Great Eka, and Teuku Mirza Iskandar. "Endometrial thickness is a prognostic factor in endometrial carcinoma." Bali Medical Journal 12, no. 2 (2023): 2083–87. http://dx.doi.org/10.15562/bmj.v12i2.4552.

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Background: Ultrasonography is a method that is commonly used today to measure endometrial thickness. It is useful as the initial step to detect endometrial hyperplasia or cancer in women with abnormal uterine bleeding. This study seeks to explore the predictive role of endometrial thickness in the development of endometrial cancer and identify the variables that affect endometrial thickness. Methods: This study is a cross sectional retrospective analytical study of women with a history of endometrial cancer who underwent transabdominal ultrasonography or transvaginal ultrasonography (TVS) fol

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Vukićević, D., Ž. Perišić, V. Plešinac-Karapandžić, et al. "ENDOMETRIAL CARCINOMA." Praxis medica 36, no. 2 (2008): 103–10. http://dx.doi.org/10.70949/pramed200802257v.

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&lt;p&gt;Endometrial carcinoma is still one of the most common malignant tumor of the female genital system in the most industrialized countries. Endometrial cancer is due to 3,9% of all female malignant tumors. The occurence of endometrial cancer varies with age. In 75% of all cases endometral carcinoma tipically occurs in postmenopausal women, with the highest incidence between 50 and 59 year. The high frequence of endometrial carcinoma in younger age is also found in women with ovarian estrogen-secreting tumors. About 10% of all endometrial carcinomas also in association with a gene

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Danolić, Damir, Luka Marcelić, Ilija Alvir, et al. "Rare case of invasive lobular breast cancer metastasis to the endometrium." Libri Oncologici Croatian Journal of Oncology 48, no. 2-3 (2020): 116–18. http://dx.doi.org/10.20471/lo.2020.48.02-03.19.

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Metastases to the female genital tract from extra-genital primary cancers are uncommon and usually occur during widespread metastatic disease. Breast cancers are the most frequent primaries, predominantly the lobular type. Here, we report a case of a 55-year-old woman with breast cancer endometrial metastasis who presented with postmenopausal vaginal bleeding. We highlight the importance of endometrial sampling to confirm the diagnosis and distinguish primary from metastatic cancer of the endometrium since the treatment and prognosis of these conditions are entirely different.

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Liu, Xuerun, Jianliu Wang, and Jingyi Zhou. "The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma." Gynecology and Obstetrics Clinical Medicine 4, no. 1 (2024): e000012. http://dx.doi.org/10.1136/gocm-2024-000012.

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Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of o

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Saleh, Agustria Z. "PREVENTION OF ENDOMETRIAL CANCER." Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya 3, no. 1 (2021): 154–58. http://dx.doi.org/10.32539/confmednatalisunsri.v3i1.85.

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Endometrial carcinoma is a malignancy originating from the epithelial cells lining the uterine cavity. 1,3 Currently, endometrial carcinoma is often found in gynecological malignancies. Endometrial carcinoma is the sixth leading cause of death from malignancy in women. In Indonesia, endometrial cancer ranks third for genital cancer after cervical (cervical) and ovarian cancer. An endometrial biopsy is done to diagnose and evaluate abnormal intrauterine bleeding, t. However, in patients who cannot undergo an endometrial biopsy because of cervical stenosis or symptoms persist despite normal biop

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Coelho, Jyotsna Mirabel, Nagarathna G., and Dinesh Shet. "Study of tamoxifen associated endometrial changes in women with breast cancer: a prospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 12 (2023): 3542–47. http://dx.doi.org/10.18203/2320-1770.ijrcog20233631.

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Background: Studies have estimated that women with breast cancer on tamoxifen therapy have a greater risk of developing endometrial cancer. We undertook this study to correlate the ultrasonographic findings, hysteroscopy findings and endometrial pathology in breast cancer patients on tamoxifen. Methods: This was a prospective study conducted over a period of two years. Patients of histologically proven breast cancer on tamoxifen treatment for more than a year were taken into the study. Transvaginal ultrasonography and hysteroscopic biopsy (if endometrial thickness on TVS was 8mm or more) was p

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Ferrer, Alejandra I., Ella Einstein, and Sara S. Morelli. "Bone Marrow-Derived Cells in Endometrial Cancer Pathogenesis: Insights from Breast Cancer." Cells 11, no. 4 (2022): 714. http://dx.doi.org/10.3390/cells11040714.

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Endometrial cancer is the most common gynecological cancer, representing 3.5% of all new cancer cases in the United States. Abnormal stem cell-like cells, referred to as cancer stem cells (CSCs), reside in the endometrium and possess the capacity to self-renew and differentiate into cancer progenitors, leading to tumor progression. Herein we review the role of the endometrial microenvironment and sex hormone signaling in sustaining EC progenitors and potentially promoting dormancy, a cellular state characterized by cell cycle quiescence and resistance to conventional treatments. We offer persp

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Kuru, Oguzhan, Ipek Betul Ozcivit Erkan, Cansu Turker Saricoban, Utku Akgor, Neslihan Gokmen Inan, and Sennur Ilvan. "The Role of Endometrial Sampling before Hysterectomy in Premenopausal Women with Abnormal Uterine Bleeding." Journal of Clinical Medicine 13, no. 13 (2024): 3709. http://dx.doi.org/10.3390/jcm13133709.

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Background/Objectives: An endometrial sampling is recommended for patients experiencing abnormal uterine bleeding above the age of 40 or 45. Valid risk prediction models are needed to accurately assess the risk of endometrial cancer and avoid an unnecessary endometrial biopsy in premenopausal women. We aimed to assess the necessity and usefulness of preoperative endometrial sampling by evaluating premenopausal women who underwent hysterectomy for abnormal uterine bleeding after preoperative endometrial sampling at our clinic. Methods: A retrospective analysis was conducted on 339 patients who

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Umar, M., MS Shehu, and Y. Iliyasu. "ENDOMETRIAL CANCER IN ZARIA, NIGERIA: A TWENTY YEAR HISTOPATHOLOGICAL ANALYSIS (1991 - 2010)." Caliphate Medical Journal 9, no. 3 (2021): 577–80. http://dx.doi.org/10.47837/cmj.202193.3.

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Background: Cancer has become a major global public health problem. There are approximately 150,000 cases of endometrial cancer diagnosed each year, making endometrial carcinoma the fifth most common cancer in women. The predisposing factor was linked to reproductive history with duration and type of oestrogen exposure. Endometrial cancer is often diagnosed early. There has not been a comprehensive clinico-pathological study/ documentation of endometrial cancer in the study center. Materials and Method: This is a retrospective histopathological review of endometrial cancer seen over 20- year p

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Bohiltea, Roxana Elena, Corina Grigoriu, Bianca-Margareta Mihai, et al. "Ten ultrasound endometrial issues." Romanian Medical Journal 68, S6 (2021): 37–48. http://dx.doi.org/10.37897/rmj.2021.s6.7.

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Abnormal uterine bleeding is probably the most frequent gynecological issue that leads women to a consult with a subsequent ultrasound. Transvaginal ultrasonographic evaluation represents the most sensitive method of endometrial evaluation, being more adequate than the transabdominal approach, especially when differentiating the benign lesions from the malignant ones. Transvaginal ultrasound is extremely useful in measurement, morphology and vascularization examination of the uterine cavity, especially the endometrium. We present 10 endometrial issues in which transvaginal ultrasound has prove

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Liu, Ming-Ming, Yu-Ting Liang, and Er-Hu Jin. "Endometrial carcinoma with cervical stromal invasion: Three case reports." World Journal of Clinical Cases 12, no. 24 (2024): 5583–88. http://dx.doi.org/10.12998/wjcc.v12.i24.5583.

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BACKGROUND Endometrial cancer is a kind of well-known tumors of female genitourinary system. Cervical stromal invasion is an adverse factor for poor prognosis of endometrial cancer. There is still controversy regarding the use of magnetic resonance imaging (MRI) in the diagnosis of cervical stromal invasion of endometrial cancer. The diagnosis of cervical stromal invasion varies significantly between different observers and institutions. We present a limited case series of the particular pattern of endometrial cancer, which infiltrates the cervical stroma and is often overlooked. CASE SUMMARY

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Lépine, Johanie, Etienne Audet-Walsh, Jean Grégoire, et al. "Circulating Estrogens in Endometrial Cancer Cases and Their Relationship with Tissular Expression of Key Estrogen Biosynthesis and Metabolic Pathways." Journal of Clinical Endocrinology & Metabolism 95, no. 6 (2010): 2689–98. http://dx.doi.org/10.1210/jc.2010-2648.

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Abstract Background: Endometrial cancer is the most common gynecological malignancy. Estrogen exposure is strongly associated with endometrial cancer. Whereas this cancer occurs predominantly in postmenopausal women lacking estrogen production by ovaries, the conversion of adrenal androgen-estrogen precursors to estradiol (E2), estrone (E1), and its sulfate (E1-S) has been well documented in peripheral tissues. Experimental Design: We initially explored whether circulating levels of estrogens, measured by validated mass spectrometry assays, differ in women with endometrial cancer (n = 126) com

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Silveira, Débora Filardi, Carlos Alberto Rodrigues Junior, Fellipe Camargo Ferreira Dias, Camila Filardi Silveira, and Caroline Filardi Silveira. "Avaliação ultrassonográfica no espessamento endometrial: revisão de literatura." Revista de Patologia do Tocantins 4, no. 4 (2017): 60. http://dx.doi.org/10.20873/uft.2446-6492.2017v4n4p60.

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Introdução: A avaliação ecográfica do endométrio permite a análise minuciosa da mucosa uterina na prática clínica ginecológica, com o intuito de auxiliar no manejo das patologias endometriais. Neste artigo, fazemos uma revisão narrativa para avaliar o real papel da ecografia pélvica na visualização das doenças endometriais. As alterações uterinas, como pólipos, miomas, sinéquias uterinas, hiperplasia e câncer endometrial são morbidades frequentes na população feminina, tanto nas pacientes em idade reprodutiva como nas que estão na pós-menopausa. Os métodos de avaliação endometrial têm obtido d

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Honda, Michiko, Akira Tsuchiya, Wataru Isono, et al. "Endophytic-Type Endometrial Cancer with Adenomyosis Successfully Diagnosed with Hysteroscopic Endometrial Biopsy Using an 8.3-mm Operative Resectoscope: A Case Report." Case Reports in Oncology 11, no. 2 (2018): 311–17. http://dx.doi.org/10.1159/000489084.

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In order to diagnose endometrial cancer preoperatively, outpatient endometrial biopsy with a curette is frequently performed owing to its convenience. However, in some cases, gynecologists fail to diagnose endometrial cancer via outpatient endometrial biopsy because of the cancer’s distribution in the uterus and its consistency. A 57-year-old Japanese woman (gravida 4 para 4) presented with a 6-month history of light but intermittent postmenopausal vaginal bleeding. A malignant uterine tumor was strongly suspected after imaging using ultrasound examination and magnetic resonance imaging; howev

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Goda, Atsushi, Satoru Meguro, Yoshikazu Johmura, et al. "Abstract 5278: Fbxo22 regulates estrogen signaling and suppresses tamoxifen-induced endometrial cancer." Cancer Research 83, no. 7_Supplement (2023): 5278. http://dx.doi.org/10.1158/1538-7445.am2023-5278.

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Abstract Introduction: Selective estrogen receptor modulators (SERMs), such as tamoxifen, function as agonists or antagonists for estrogen receptors (ERs) in a tissue-specific manner. We have discovered that Fbxo22, a F-box subunit of SCF ubiquitin ligase complex is critical for the functional alteration of SERM (Johmura, et al., J Clin Invest, 2018). SCFFbxo22 ubiquitinates and degrades lysine demethylase 4B (KDM4B) complexed with SERM-bound ER, that triggers release of coactivator SRC from ER, thus mediating antagonistic function of SERM. Without Fbxo22, stabilized KDM4B mediates the interac

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Yadav, Budhi Singh, Suresh C. Sharma, Firuza D. Patel, Bhavana Rai, and Sushmita Ghoshal. "Gynecological Cancer as a Second Malignancy in Patients With Breast Cancer." International Journal of Gynecologic Cancer 27, no. 6 (2017): 1298–304. http://dx.doi.org/10.1097/igc.0000000000000993.

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PurposeThe aim of this study was to determine the incidence and risk factors for gynecological cancer as second malignancy (SM) after treatment of breast cancer (BC).Methods and MaterialsBetween January 1985 and December 2007, a total of 2756 patients with BC were analyzed for gynecological cancers as an SM. Analysis was carried out for patient-, disease-, and treatment-related characteristics. The Cox proportional hazards regression model was used to estimate the relative risk of gynecologic malignancies.ResultsThe median age at BC diagnosis was 49 years and median follow-up of 14 years. In t

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Unicsovics, Márkó, Zsófia Molnár, Miklós Mézes, et al. "The Possible Role of Mycotoxins in the Pathogenesis of Endometrial Cancer." Toxins 16, no. 6 (2024): 236. http://dx.doi.org/10.3390/toxins16060236.

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Endometrial cancer is one of the most common cancer types among women. Many factors can contribute to the development of this disease, including environmental factors and, thus, eating habits. Our study aims to determine the levels of various mycotoxins and their metabolites in the blood serum and endometrial tissue samples of participants with previously proven endometrial cancer and to find possible contributions to cancer development. In the cohort clinical trial, 52 participants aged between 44 and 86 were studied. The participants were divided into two groups: patients or matched controls

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Boardman, Lori, Akiva P. Novetsky, and Fidel Valea. "Management of Endometrial Intraepithelial Neoplasia or Atypical Endometrial Hyperplasia." Obstetrical & Gynecological Survey 78, no. 12 (2023): 731–33. http://dx.doi.org/10.1097/ogx.0000000000001229.

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(Abstracted from Obstet Gynecol 2023;142(3)) Endometrial cancer incidence is rising in the United States and disproportionally affects patients based on race, geography, and socioeconomic status. Endometrial intraepithelial neoplasia (EIN) or atypical endometrial hyperplasia (AEH) is often precursor lesions to adenocarcinoma in the endometrium.

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Costa, Bruna Pasqualotto, Fernanda Bordignon Nunes, Francini Corrêa Noal, and Gisele Branchini. "Ion Channels in Endometrial Cancer." Cancers 14, no. 19 (2022): 4733. http://dx.doi.org/10.3390/cancers14194733.

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Uterine or endometrial cancer (EC) is the sixth most common neoplasia among women worldwide. Cancer can originate from a myriad of causes, and increasing evidence suggests that ion channels (IC) play an important role in the process of carcinogenesis, taking part in many pathways such as self-sufficiency in growth signals, proliferation, evasion of programmed cell death (apoptosis), angiogenesis, cell differentiation, migration, adhesion, and metastasis. Hormones and growth factors are well-known to be involved in the development and/or progression of many cancers and can also regulate some io

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