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Journal articles on the topic 'Endometriosis and Ovulatory Infertility (OI)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Shilpa, Shekhar Ingle. "Exploring the Link Between Hormonal Markers and Sexual Behavior in Female Infertility." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 626–30. https://doi.org/10.5281/zenodo.12734661.

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<strong>Background: </strong>This study explores the intricate relationship between hormonal markers and sexual behavior in the context of female infertility. Hormonal imbalances, often a root cause of infertility, can significantly influence sexual desire, arousal, and overall sexual health. By examining key hormonal markers such as estrogen, progesterone, and luteinizing hormone, this research aims to elucidate their impact on sexual behavior patterns in infertile women. Through a comprehensive review of existing literature and analysis of clinical data, we identify how these hormonal f

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Haney, AF. "Endometriosis-associated infertility." Reproductive Medicine Review 6, no. 3 (1997): 145–61. http://dx.doi.org/10.1017/s0962279900001496.

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Despite intense clinical interest, increasing numbers of infertile couples with endometriosis-associated infertility and ever more sophisticated diagnostic technology, optimal treatment of the infertility remains frustrating. In the absence of mechanical compromise of the pelvic viscera, there is no treatment directed towards the endometriosis itself, medical or surgical, which alleviates the infertility experienced by these couples. The reason for this lack of therapeutic progress is most likely related to the lack of consensus regarding the mechanism(s) by which the endometriosis or its path

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Lin, Yi-Heng, Ya-Hsin Chen, Heng-Yu Chang, Heng-Kien Au, Chii-Ruey Tzeng, and Yen-Hua Huang. "Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies." International Journal of Molecular Sciences 19, no. 8 (2018): 2385. http://dx.doi.org/10.3390/ijms19082385.

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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, an

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Bespalova, Jeanne V., N. I. Volkov, and Vladimir I. Kulakov. "Early diagnosis of external genital endometriosis in women with infertility." Journal of obstetrics and women's diseases 53, no. 2 (2004): 11–15. http://dx.doi.org/10.17816/jowd87947.

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The article reports on the results of the analysis of the reliability of symptoms of external genital endometriosis. Mathematical processing of these signs using the total probability formula made it possible to calculate the statistical probability of endometriosis in the presence of each sign individually or in their random combination in a woman with infertility and a regular ovulatory menstrual cycle.

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Shanmugham, Deepa, Nambala Divya Sahitya, Sindhu Natarajan, and Deepak Kannan Saravanany. "Role of diagnostic hystero-laparoscopy in the evaluation of female infertility." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 8 (2019): 3156. http://dx.doi.org/10.18203/2320-1770.ijrcog20193528.

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Background: Infertility affects about 10-15% of reproductive age couples. The main causes of infertility include male factor, ovulatory disorders, tubal factor and endometriosis. This study was conducted to determine the role of Diagnostic hystero-laparoscopy (DHL) in the evaluation of female infertility.Methods: This study was a prospective study done in a tertiary care centre over a period of 1 year on all infertile couples. The exclusion criteria: male factor infertility, hypothyroidism, hyperprolactinemia, acute pelvic inflammatory disease. Diagnostic hysterolaparoscopy was performed in al

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KHMIL, S. V., and I. YA PIDHAINA. "CLINICAL RESULTS IN WOMEN WITH FERTILITY DUE TO ENDOMETRIOS IN THE PROTOCOLS OF ASSISTED REPRODUCTIVE TECHNOLOGIES." Scientific digest of association of obstetricians and gynecologists of Ukraine, no. 2(50) (September 22, 2022): 95–103. http://dx.doi.org/10.35278/2664-0767.2(50).2023.275000.

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Surgical treatment of ovarian endometriosis remains a controversial issue. Sclerotherapy of endometrioma as a minimally invasive and affordable method proves its effectiveness for this category of patients, confirming it with clinical results in ART protocols. The aim is to study the effectiveness of protocols of controlled ovarian stimulation using protocol pretreatment therapy and sclerotherapy in patients with endometriosis-associated infertility in assisted reproductive technology programs. Materials and methods. 126 women with endometriosis-associated and tubal infertility wer

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G., Veerarajeswari, Jeyapraba L., and Ajaz Haja Mohideen R. "ASSESSMENT OF INFERTILITY PROBLEMS AMONG FEMALE IN RAMANATHAPURAM, TAMILNADU." International Journal of Multidisciplinary Research and Modern Education 3, no. 1 (2017): 530–35. https://doi.org/10.5281/zenodo.826919.

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Infertility is the inability to conceive after one year of unprotected intercourse. Identifiable factors affecting female infertility include hormonal or endocrine disturbances (menstrual or ovulatory disturbances), tubal factors (occlusions, pelvic adhesions and other tubal abnormalities), acquired non-tubal factors (cervical or uterine disturbances), sexual dysfunction and congenital abnormalities. The present research work aimed to study the infertility problem according to demographic and socioeconomic characteristics such as age, education, occupation, BMI and gynecological and clinical c

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Yarmolinskaya, Mariya I., and Elena I. Durneva. "Modern capabilities of reproductive function realization for patients affected by deep infiltrative endometriosis." Journal of obstetrics and women's diseases 66, no. 1 (2017): 77–81. http://dx.doi.org/10.17816/jowd66177-81.

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It is agreed that endometriosis is a disease that has a negative impact on fertility. Factors causing decrease in fertility in patients with endometriosis are very diverse: peritoneal factors, including changes in peritoneal fluid, adhesions, changes in anatomy of pelvis and impaired properties of peritoneum which may also lead to the tubal factor of infertility; ovarian factors which are linked with endocrine and ovulatory changes and lead to disturbance in oocyte quality and quality of embryos; factors leading to implantation disturbances. There are different types of strategies for overcomi

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Bulun, Serdar E., Bahar D. Yilmaz, Christia Sison, et al. "Endometriosis." Endocrine Reviews 40, no. 4 (2019): 1048–79. http://dx.doi.org/10.1210/er.2018-00242.

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AbstractPelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extrauterine endometriotic tissue involve defectively programmed endometrial mesenchymal progenitor/stem cells. Although endometriotic stromal c

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Albogamy, ‏Sahar Adi, ‏Ahmad Alhelo Alanazi, ‏Mona Mudlah Alsaadi, et al. "Infertility: causes, diagnostic approaches, and treatment modalities-An updated review." International journal of health sciences 4, S1 (2020): 299–319. http://dx.doi.org/10.53730/ijhs.v4ns1.15236.

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Background: Infertility significantly affects individuals' psychological and physical well-being, with notable implications for couples. This review primarily focuses on female infertility, emphasizing the importance of understanding normal fecundability and its impact on clinical management. Aim: To provide an updated review of the causes, diagnostic approaches, and treatment modalities for female infertility. Methods: A comprehensive literature review was conducted to analyze the prevalence, etiological factors, pathophysiology, diagnostic strategies, and treatment options for female inferti

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Sipahi, Mehmet, Şebnem Alanya Tosun, and Sadettin Oguzhan Tutar. "Experience of our clinic in intrauterine insemination cycles made with microfluidic sperm sorting chips." Aegean Journal of Obstetrics and Gynecology 3, no. 1 (2021): 15–18. http://dx.doi.org/10.46328/aejog.v3i1.81.

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Objective: Determination of the clinical pregnancy rate in intrauterine insemination (IUI) cycles performed with microfluidic sperm sorting chips. Material and Methods: In Giresun University Obstetrics and Pediatrics Hospital Infertility Clinic, 133 patients who underwent IUI after ovarian stimulation with gonadotropins in unexplained infertility, mild to moderate male factor, ovulatory dysfunction, mild endometriosis were retrospectively analyzed between January 2016-January 2020. Microfluidic sperm sorting chip was used for sperm preparation. Results: The number of cycles was fou

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R, Purohit. "A Critical Review on Bandhyatva (Anovulation)." Journal of Natural & Ayurvedic Medicine 7, no. 2 (2023): 1–8. http://dx.doi.org/10.23880/jonam-16000403.

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Infertility is defined as the failure to conceive after one year of regular intercourse without the use of contraceptive. The difficulty to conceive or subfertility constitutes a major social and psychological burden amongst couples. Premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, uterine fibroids, and endometrial polyps are all potential causes of female infertility, with ovulatory issues being the most common ones. Various factors including genetic disorders, advancing age, poor nutrition, environmental pollution, and increased stress in daily life, may all contr

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Jahan, S. "Role of Laparoscopy in Infertility : Review Article." BIRDEM Medical Journal 2, no. 2 (2012): 99–103. http://dx.doi.org/10.3329/birdem.v2i2.12324.

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Infertility is defined as failure to conceive during one year of unprotected frequent intercourse. Leading causes of infertility include tubal disease, ovulatory disorders, uterine or cervical factors, endometriosis and male factor infertility. A laparoscope is a thin fiber optic telescope that is inserted into the abdomen usually through the belly button. The fiber optics allow a light to used to see inside the abdomen. Carbon dioxide (CO2) gas is placed into the abdomen prior to inserting the laparoscope. Generally, laparoscopy should be reserved for couples who have already completed a more

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Namarta, Kumari, Ahuja Nupur, Choudhary Shruti, and Tyagi Anjali. "Hormone Marker-Sexual Behavior Correlation in Female Infertility." International Journal of Toxicological and Pharmacological Research 13, no. 10 (2023): 444–48. https://doi.org/10.5281/zenodo.11078927.

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<strong>Background:  </strong>When a female partner is the source of the infertility, it is referred to as female infertility. Women may have inherited or acquired infertility. Acquired factors are those that are not derived from genetic mutations. Injuries to the uterus or fallopian tubes, problems with the cervix, and ovulation disorders are the most common causes of infertility in women. Age is another factor that leads to infertility because a woman’s fertility generally decreases with age. The American Society for Reproductive Medicine (ASRM) states that factors that can affect

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B., Pandeeswari, and Shalini Mahana Valecha. "A prospective study on the role of Hysterolaparoscopy in the evaluation of infertility." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 12 (2019): 4766. http://dx.doi.org/10.18203/2320-1770.ijrcog20195317.

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Background: Infertility affects about 10-15% of couples of reproductive age groups. The current evidence indicates a 9% prevalence of infertility with 56% of couples seeking medical care. Hysterolaparoscopy provides a comprehensive investigative procedure in which various factors causing female infertility can be assessed at one sitting.Methods: A total 100 infertile women between 20-40 years of age including primary and secondary infertility were evaluated. Patients would be investigated thoroughly for infertility and in preparation for anaesthesia. Tests include follicular study, Ultrasound

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Wardle, P. G., E. A. Mclaughlin, A. Mcdermott, J. D. Mitchell, B. D. Ray, and M. G. R. Hull. "ENDOMETRIOSIS AND OVULATORY DISORDER: REDUCED FERTILISATION IN VITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY." Lancet 326, no. 8449 (1985): 236–39. http://dx.doi.org/10.1016/s0140-6736(85)90289-2.

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Wankhede, Sachin, Sarika Thakare, Nivedita Goverdhan, and Santosh Shahane. "Evaluation of cases of infertility by diagnostic laparoscopy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 3 (2017): 924. http://dx.doi.org/10.18203/2320-1770.ijrcog20170557.

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Background: Infertility affects nearly 10-15% of couples and is an important part of clinical practice. Leading causes of infertility include tubal disease, ovulatory disorders, uterine or cervical factors, endometriosis and male factor infertility. The objective of the study was to find out different causes of female infertility with diagnostic laparoscopy.Methods: This was a descriptive study conducted from February 2012 to November 2013. 115 patients with infertility attending the infertility clinic in OPD of Obstetrics and Gynaecology were evaluated clinically with detailed history. The ne

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Lorzadeh, Nahid, and Nastran Kazemirad. "Infertility in Light of in vitro Fertilization and Intracytoplasmic Sperm Injection: Treatments and Associated Outcomes." Current Women s Health Reviews 16, no. 4 (2020): 285–89. http://dx.doi.org/10.2174/1573404816999200511102307.

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Over the years, the efficacy of assisted reproductive technologies has significantly improved. Infertility-associated problems like tubal obstruction, severe male-factor infertility, severe endometriosis and ovulatory dysfunction have entailed the need for in vitro fertilization (IVF). Intracytoplasmic sperm injection (ICSI) is the insertion of a single and viable spermatozoon into the oocyte, thereby circumventing the penetration of the oocyte membranes and aiding gamete fusion process. The use of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are the most commonly p

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Bairagi, Tanishka, Ankit Verma, S. P. Srinivas Nayak, and Gunosindhu Chakraborthy. "Understanding Female Infertility: A Prospective Study on Prevalence and Associated Factors." Journal of Neonatal Surgery 14, no. 19S (2025): 587–96. https://doi.org/10.63682/jns.v14i19s.4825.

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Background: Female infertility is a global health concern affecting millions of women, with causes ranging from hormonal imbalances and ovulatory disorders to structural abnormalities and lifestyle factors. Conditions like PCOS, endometriosis, and tubal blockages contribute significantly to infertility rates. Understanding its prevalence, risk factors, and treatment options is crucial for developing effective therapeutic strategies and improving reproductive health outcomes. Material & Method: This prospective study analyzed 118 young females with primary or secondary infertility to assess

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F, Naeem. "Prevalence Along with Diagnostic Modalities and Treatment of Female Infertility Due to Female Genital Disorders." Virology & Immunology Journal 4, no. 3 (2020): 1–6. http://dx.doi.org/10.23880/vij-16000249.

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Infertility is a communal pathological ailment now-a-days worldwide and approximately females are mostly suffering from this condition. In previous studies, out of 2.4 million married couples have females in between the ages from 15-44 year; 1.0 million couples were suffering from primary infertility and 1.4 million couples had secondary infertility. The infertility causes are ovulatory factors, dietary factors, psychological factors, abnormal endocrine functions, fallopian tube disorders etc. PCOS, PIDs, endometriosis. The ultrasonography is the most powerful tool for diagnosis. The treatment

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Yu-Rice, Yi, Seby L. Edassery, Nicole Urban, et al. "Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer." Reproduction 153, no. 3 (2017): 277–84. http://dx.doi.org/10.1530/rep-16-0265.

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Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n = 41), infertility (n = 92) and control (n = 87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis. The percent of anti-SBP1-positive sera was higher in POF (P = 0.02),

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Ahmad Dritto Kluge Rifasky, Zakiyatul Faizah, Jimmy Yanuar Annas, and Sri Ratna Dwiningsih. "Comparison of pregnancy success rates in ICSI (Intracytoplasmic Sperm Injection) success rates in cases of male and female infertility at the Graha Amerta Fertility Clinic, RSUD Dr. Soetomo Hospital, Surabaya, for the period 2018 – 2022: A Literature Revi." Magna Scientia Advanced Research and Reviews 12, no. 2 (2024): 381–87. https://doi.org/10.30574/msarr.2024.12.2.0214.

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Infertility, defined as the inability to conceive after one year of unprotected intercourse (WHO, 2012), affects 8–10% of couples worldwide, equivalent to 50–80 million couples, with 2 million new cases annually (WHO, 2013). In Indonesia, 10–15% of the 39.6 million reproductive-age couples face infertility, with primary causes including sperm issues (35%), ovulatory disorders (20%), fallopian tube blockages (20%), endometriosis (20%), and idiopathic factors (10%). The prevalence is rising both globally and domestically, with infertile women in the U.S. projected to reach 7.7 million by 2025. A

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Dubinina, V. G., О. М. Nosenko, O. I. Chuzhyk, and G. S. Grytsenko. "Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas." HEALTH OF WOMAN, no. 6(112) (July 29, 2016): 165–68. http://dx.doi.org/10.15574/hw.2016.112.165.

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The objective: of the study was to investigate the indicators of ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas more than 3 cm in diameter. Patients and methods. It were examined 63 patients of reproductive age with ovarian endometriosis, including 33 with unilateral ones and 30 with bilateral. The control group consisted of 30 conditionally somatically healthy women of reproductive age with secondary tubal infertility, with regular ovulatory menstrual cycle. All the women were operated on. Prior to the surgery it were studied biochemical and son

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Ganjare, Roshani, and Anjali Mangalaram. "Association between infertility and risk of cardiovascular diseases in young women." F1000Research 13 (May 17, 2024): 510. http://dx.doi.org/10.12688/f1000research.146939.1.

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Scientists and medical experts are beginning to understand the significant role that a woman’s past reproductive experiences play in her potential risk of developing heart disease. Reproductive history is seldom considered when assessing the cardiovascular risk. Infertility, high blood pressure, and hypertension are risk factors for heart disease. Additional analyses were conducted to determine whether the apparent increase in risk could be influenced by other risk factors associated with infertility such as irregular menstruation, thyroid conditions, and waist circumference. This study aimed

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Hisnindarsyah and Ahyar Wahyudi. "Effect of Hyperbaric Oxygen Therapy on Enhancing Fertility (Literature Review)." Jurnal Multidisiplin Madani 3, no. 10 (2023): 2091–98. http://dx.doi.org/10.55927/mudima.v3i10.6427.

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Ovulatory disorders, damage to the fallopian tubes, uterine issues, and conditions such as endometriosis have been identified as primary causes of female infertility. This article aims to explore the potential of hyperbaric oxygen therapy in enhancing fertility. Hyperbaric Oxygen Therapy (HBOT) is a medical procedure that involves inhaling pure oxygen (100%) within a chamber or room under pressure higher than normal atmospheric pressure, specifically over 1 absolute atmosphere (ATA), to accelerate and enhance the body's healing and recovery abilities. Under elevated atmospheric pressure, gaseo

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De Abreu, Lauriane G., Vanessa S. Silveira, Carlos A. Scrideli, et al. "Endometriosis does not Alter Aromatase Gene Expression (CYP19A1) in Mural Lutein-granulosa Cells of Women Undergoing Assisted Reproduction Techniques – a Pilot Study." Journal of Endometriosis 3, no. 4 (2011): 177–82. http://dx.doi.org/10.5301/je.2012.9070.

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Purpose The aim of this study was to quantify aromatase gene expression in mural lutein-granulosa cells of women with endometriosis undergoing assisted reproduction techniques (ART, IVF or ICSI). Methods: a case-control study was performed on 11 women with endometriosis (all stages, ASRM criteria) and 11 women with male or tubal causes of infertility undergoing ART. There was no difference between the groups regarding age, amount of gonadotrophins used, days of induction, follicles, and eggs collected. Mural lutein-granulosa cells were harvested from pre-ovulatory follicles during oocyte retri

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Antaratani, Ramalingappa C., and Harsha B. "Hysterolaparoscopy in the evaluation and management of female infertility." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 10 (2017): 4454. http://dx.doi.org/10.18203/2320-1770.ijrcog20174423.

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Background: To study the role of hysterolaparoscopy in the evaluation and management of female infertility.Methods: A retrospective study of the 677 case files of all the patients who underwent diagnostic hysterolaparoscopy for infertility between January 2011 to December 2016 at Karnataka Institute of Medical Sciences, Hubli and Sushruta Multispeciality hospital, Hubli. These infertile women were confirmed to have normal ovulatory cycles, hormonal assays and seminogram report. Dye studies as well as inspection for abnormal pelvic and intrauterine pathology and necessary therapeutic interven-t

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Soni, Monica, and Santosh Kumari. "Prospective evaluation of causes of infertility at a tertiary care hospital." International Journal of Research in Medical Sciences 6, no. 12 (2018): 3988. http://dx.doi.org/10.18203/2320-6012.ijrms20184895.

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Background: Infertility is defined as the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Worldwide, its prevalence is approximately 8-12%. There are numerous factors such as anatomical, physiological, genetic, environmental and acquired factors that cause infertility. The aim of the present study was to determine the causes and clinical pattern of infertility in infertile couples in North West India.Methods: It was a hospital based observational study carried out on 211 infertile couples in reproductive age group attending infertility

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K. Junnare, Ketaki, Gulab Singh Shekhawat, Sonali Ingole, and Milind Sintre. "THE ROLE OF HYSTEROLAPAROSCOPY OVER HYSTEROSALPINGOGRAPHY IN THE EVALUATION AND MANAGEMENT OF FEMALE INFERTILITY: A DIAGNOSTIC-CUM FERTILITY ENHANCING THERAPEUTIC TOOL." International Journal of Advanced Research 10, no. 05 (2022): 375–82. http://dx.doi.org/10.21474/ijar01/14718.

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Background and objective:The technological advancement in endoscopic instruments has revolutionized the management of female infertility. Our objective was to compare the diagnostic and therapeutic efficacy of Hysterolaparoscopy over Hysterosalpingography in infertile patients and also to assess is there any needfor doing HSG ininfertility evaluation. Methods:100 infertile women who wereconfirmed to have normal ovulatory cycles, hormonal assays, and husband semen analysis were enrolled.HSG was performed as a basic test for the evaluation of tubes and the uterine cavity. All 100 women were also

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Banu, Neher, Joynab Akhter, and Mina Rani Debi. "A Retrospective Study of Leparoscopic Evaluation of Tubal Factors in Case of Infertility." Scholars International Journal of Obstetrics and Gynecology 7, no. 09 (2024): 456–60. http://dx.doi.org/10.36348/sijog.2024.v07i09.010.

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Background: Tubal factor infertility accounts for a large portion of female factor infertility. The most prevalent cause of tubal factor infertility is pelvic inflammatory disease and acute salpingitis. Tubal factor infertility accounts for approximately 25-35% of cases of female infertility. The aim of this study was to determine the role of leparoscopic evaluation of Tubal factors in case of infertility. Methods: A retrospective study was carried out at Department of Gynae and Obstetrics UHC, Dhamrai, Dhaka, Bangladesh from January to December 2023. 55 patients were selected for laparoscopic

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Vanitha S, Victoria Job, and Aleyamma T K. "Evaluation of vitamin E levels, antioxidant enzymes and malondialdehyde in women with unexplained infertility." International Journal of Clinical Biochemistry and Research 10, no. 3 (2023): 193–99. http://dx.doi.org/10.18231/j.ijcbr.2023.034.

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Unexplained infertility is a perplexing disorder. 30% of infertile couples are diagnosed with unexplained infertility with all standard fertility investigations normal. Oxidative stress has been shown to have a negative impact on reproductive function in women with endometriosis and (PCOS) polycystic ovarian syndrome. In another study antioxidant supplementation improved OS induced infertility. Many studies have demonstrated an increase in Malondialdehyde in serum of women with infertility and vitamin E as a protective antioxidant in the body with positive effect on the fertility. There is gro

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Dufour, Stephanie, Mathieu Viau, Maxime Côté, Jessica Lefebvre, Sarah Maheux-Lacroix, and Marie-Ève Bergeron. "Impact of a Pozzi tenaculum forceps use on the success rate of intrauterine insemination (IUI) : protocol for a randomised control trial." BMJ Open 11, no. 3 (2021): e043230. http://dx.doi.org/10.1136/bmjopen-2020-043230.

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IntroductionA therapeutic option frequently proposed for infertility is to proceed first with intrauterine insemination (IUI) cycles. Little is known on the effect of uterine contractions on IUI success rates. We postulated that uterine contractions may help with sperm migration in the women’s genital tract. Our objective is to compare the efficacy of IUI when performed with and without a tenaculum forceps on the cervix.Methods and analysisWe are conducting a randomised controlled trial with women aged 18–40 years old, diagnosed with primary or secondary infertility due to endometriosis, mild

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Sharma, Pankaj, Ashok Verma, and Kritika Katoch. "Relationship between pregnancy rate and number of intrauterine insemination cycles during the study of comparative efficacy of letrozole and clomiphene citrate adjuvants to gonadotropin stimulation in controlled ovarian stimulation cycles combined with intrauterine insemination therapy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 11, no. 1 (2021): 106. http://dx.doi.org/10.18203/2320-1770.ijrcog20215084.

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Background: Infertility is commonly defined as the failure of conception after at least twelve months of unprotected intercourse. Factors contributing are both male and female in which unexplained etiology accounts for 51%, male factor 28%, endometriosis 17% and ovulatory disorders 4%.Methods: Prospective, randomized study was conducted at DRRPG medical college, Tanda, Kangra, Himachal Pradesh. In our study, patients were randomized into two groups of 30 each. Women in group A received clomiphene citrate 100mg/day and group B received letrozole 2.5 mg/day from day 3-7 of menstrual cycle. All t

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Mohammed, Alaa, and Chiman Mawlood. "Estradiol level on day two and day of trigger: A potential predictor of the invitro fertilization success." Zanco Journal of Medical Sciences 28, no. 3 (2024): 455–63. https://doi.org/10.15218/zjms.2024.45.

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Background and objective: Infertility is defined as not getting pregnant after 12 months of unprotected sex for women under 35 or 6 months for those over 35. Ten to fifteen percent of couples struggle to conceive. All cases of infertility are evaluated; however, evaluations should be conducted sooner if there is a male factor or if the female has endometriosis, tubal illness, oligomenorrhea, or amenorrhea. Investigation includes an assessment of ovulatory function, ovarian reserve, uterinecavity, tubalpatency, and a semen analysis, diagnostic laparoscopy, hormone levels estradiol, the number o

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Deeksha, Singh1 Pooja Khanpara2 Anil Kumar3 E. Latha4 Eldhose M. J.5 Selvakumar Sambandan6 Manorama7 Yash Srivastav8 Manjari*9. "Emerging Therapeutic Approaches in Women's Reproductive Health: Current Advances in Fertility Enhancement and Management." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2244–61. https://doi.org/10.5281/zenodo.15081439.

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Infertility remains a significant challenge in women’s reproductive health, necessitating the development of innovative therapeutic strategies. Advances in pharmacological interventions, including hormonal therapies like clomiphene citrate, gonadotropins, and letrozole, have improved ovulatory function and pregnancy rates. Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), continue to evolve with the integration of artificial intelligence (AI) for embryo selection and optimization of implantation success. Additiona

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Vannuccini, Silvia, and Felice Petraglia. "Recent advances in understanding and managing adenomyosis." F1000Research 8 (March 13, 2019): 283. http://dx.doi.org/10.12688/f1000research.17242.1.

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Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified – International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual ble

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Tummon, Ian S., Victoria M. Maclin, Ewa Radwanska, Zvi Binor, and W. Paul Dmowski. "Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility**Presented at the Forty-Third Annual Meeting of The American Fertility Society, Reno, Nevada, September 28 to 30, 1987." Fertility and Sterility 50, no. 5 (1988): 716–20. http://dx.doi.org/10.1016/s0015-0282(16)60304-7.

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Yarmolinskaya, Maria I., Saimat Sh Tkhazaplizheva, Arseniy S. Molotkov, et al. "Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease." Journal of obstetrics and women's diseases 68, no. 3 (2019): 51–60. http://dx.doi.org/10.17816/jowd68351-60.

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Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor pathways. Melatonin may act through both membrane and nuclear receptors. In the present work, the expression of MTR1 and MTR2 melatonin receptors was studied in the eutopic endometrium and endometrioid heterotopies, and the level of melatonin metabolite, 6-sulfatoxymelatonin, in daily urine in patients with genital endometriosis (GE) was analyzed. Study de

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Бурлев, В. А. "Реактивность NLRP3/NOD2-инфламмасом в эутопическом эндометрии на фоне лечения перитонеальной формы эндометриоза и бесплодия". Репродуктивное здоровье. Восточная Европа 15, № 3 (2025): 288–304. https://doi.org/10.34883/pi.2025.15.3.003.

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Введение. Отсутствуют данные о влиянии лечения на активность инфламмасом в эутопическом эндометрии у пациентов с перитонеальной формой эндометриоза и бесплодием путем сравнения значений до и после лечения. Расшифровка роли изменения активности инфламмасом в наступлении беременности после лечения может оказать воздействие на разработку новых направлений терапии этого заболевания. Цель. Обосновать реактивность NLRP3/NOD2-инфламмасом в эутопическом эндометрии на фоне комплексного лечения перитонеальной формы эндометриоза и бесплодия для оценки перспективы разработки терапии, основанной на нормали

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Devesa-Peiro, A., P. Sebastian-Leon, A. Parraga-Leo, A. Pellicer, and P. Diaz-Gimeno. "Breaking the ageing paradigm in endometrium: endometrial gene expression related to cilia and ageing hallmarks in women over 35 years." Human Reproduction 37, no. 4 (2022): 762–76. http://dx.doi.org/10.1093/humrep/deac010.

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Abstract STUDY QUESTION Does age affect endometrial gene expression? SUMMARY ANSWER Using unsupervised artificial intelligence methods, we report for the first time that endometrial gene expression changes from 35 years of age in women. WHAT IS KNOWN ALREADY Female fertility declines with age, largely attributed to declining oocyte quality and ovarian reserve. Combined with other evidence, a longstanding paradigm holds that age does not affect the endometrial function and age has not been controlled for properly in endometrial studies. STUDY DESIGN, SIZE, DURATION A retrospective in silico ana

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Lin, Xiang, Xiaomei Tong, Yinli Zhang, et al. "Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2." Endocrinology, December 16, 2022. http://dx.doi.org/10.1210/endocr/bqac210.

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Abstract The mechanism by which endometriosis, a common gynecological disease characterized by chronic pelvic pain and infertility, causes infertility remains elusive. Luteinized unruptured follicle syndrome, the most common type of ovulatory dysfunction, is a cause of endometriosis-associated infertility involving reduced numbers of retrieved and mature oocytes. Ovulation is controlled by luteinizing hormone and paracrine signals produced within the follicle microenvironment. Generally, interleukin (IL)-1β is elevated in endometriosis follicular fluid, whereby it amplifies ovulation signals b

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"Ovarian diseases leading to female infertility: a mini-review." Journal of Fertility and Reproductive Health 1, no. 1 (2023). http://dx.doi.org/10.61577/jfrh.2023.100004.

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Infertility has become a significant global health issue impacting people’s lives. Among the multiple factors, including age, lifestyle, environment, ovulatory dysfunctions, etc., the current mini-review focuses on major ovarian disorders, including polycystic ovarian syndrome (PCOS), endometriosis, pelvic adhesion, uterine fibrosis, tubal factor, and hyperprolactinemia, which are strongly associated with female infertility. This mini-review showcased the cause, symptoms, and treatment of these ovulatory dysfunctions, which might help relieve infertility, and patients would have clinical benef

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Farman, Hassan Ali, and Hassan Kareem Hussien. "Evaluation of monocyte chemotactic protein-1 level in serum of fertile and infertile women." International journal of health sciences, May 23, 2022. http://dx.doi.org/10.53730/ijhs.v6ns2.7753.

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Infertility is a disease of the reproductive system characterized by inability to achieve pregnancy after 12 or more months of regular unprotected sexual intercourse (Venkatesh et al., 2014). Female infertility, as a complex disorder, may be caused by medical conditions including pelvic inflammatory disease, endometriosis related infertility, ovulatory disorders, tubal factor infertility, and unexplained infertility(Gupta et al., 2014). Infertility affect approximately nine to fifteen percent of the childbearing population, and 55% of these influenced will seek medical help to achieve their de

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Sunkara, Sesh Kamal, Belavendra Antonisamy, Ankita C. Redla, and Mohan Shashikanth Kamath. "Female causes of infertility are associated with higher risk of preterm birth and low birth weight: analysis of 117 401 singleton live births following IVF." Human Reproduction, December 25, 2020. http://dx.doi.org/10.1093/humrep/deaa283.

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Abstract STUDY QUESTION Does the cause of infertility affect the perinatal outcomes preterm birth (PTB) and low birth weight (LBW) following IVF treatment? SUMMARY ANSWER The risk of PTB and LBW was higher with female causes of infertility—ovulatory disorders, tubal disorders and endometriosis—compared to unexplained infertility but the absolute increase in risk was low. WHAT IS KNOWN ALREADY Infertility is associated with an increased risk of adverse perinatal outcomes. Risk of adverse perinatal outcomes is also higher following ART compared to spontaneous conceptions. Infertility can result

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Rotshenke. Olshinka, K., N. Steiner, E. Rubenfeld, and M. H. Dahan. "P–695 Establishing predictors of the mode of conception in fertility patients presenting with a clinical pregnancy." Human Reproduction 36, Supplement_1 (2021). http://dx.doi.org/10.1093/humrep/deab130.694.

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Abstract Study question What are the predictors for pregnancies conceived spontaneously (SC), by ovulation induction+/-insemination (OI±IUI) or via In-Vitro Fertilization(IVF), and what proportion of pregnancies were conceived with each method? Summary answer Pregnancies were conceived by SC(27.7%), OI±IUI(33%) or IVF(39.2%).Unexplained infertility positively-predicted SC and OI±IUI-conceptions. Male factor-infertility demonstrated the opposite trend, positively predicting IVF. Endometriosis negatively-predicted SC. What is known already Spontaneous conception (SC) occurs regularly among infer

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Farland, Leslie V., Yi‐Xin Wang, Audrey J. Gaskins, et al. "Infertility and Risk of Cardiovascular Disease: A Prospective Cohort Study." Journal of the American Heart Association, February 27, 2023. http://dx.doi.org/10.1161/jaha.122.027755.

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Background Certain symptoms associated with infertility are associated with cardiovascular disease, including menstrual cycle irregularity, early menopause, and obesity; however, few studies have investigated the association between infertility and cardiovascular disease risk. Methods and Results Participants in the NHSII (Nurses' Health Study II) who reported infertility (12 months of trying to conceive without success, including women who subsequently conceived) or who were gravid, with no infertility were followed from 1989 until 2017 for development of incident, physician‐diagnosed coronar

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Starosta, Anabel, Catherine E. Gordon, and Mark D. Hornstein. "Predictive factors for intrauterine insemination outcomes: a review." Fertility Research and Practice 6, no. 1 (2020). http://dx.doi.org/10.1186/s40738-020-00092-1.

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Abstract Purpose Intrauterine insemination (IUI) is a frequently utilized method of assisted reproduction for patients with mild male factor infertility, anovulation, endometriosis, and unexplained infertility. The purpose of this review is to discuss factors that affect IUI outcomes, including infertility diagnosis, semen parameters, and stimulation regimens. Methods We reviewed the published literature to evaluate how patient and cycle specific factors affect IUI outcomes, specifically clinical pregnancy rate, live birth rate, spontaneous abortion rate and multiple pregnancy rate. Results Mo

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Li, Jing-Yi, Jian-Peng Chen, Yu-Li Qian та ін. "Follicular fluid progesterone down-regulated HPGD and COX2 in granulosa cells via suppressing NF-кB in endometriosis". Biology of Reproduction, 31 січня 2023. http://dx.doi.org/10.1093/biolre/ioad014.

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Abstract Increasing evidences showed ovulatory dysfunction, possibly caused by luteinized unruptured follicular follicle syndrome(LUFS), is one of the reasons for endometriosis-related infertility. The present study was conducted to explore the potential effect of elevated progesterone in follicular fluid (FF) on ovulation in endometriosis. A prospective study including 50 ovarian endometriosis patients and 50 control patients with matched pairs design was conducted with alterations in FF and peritoneal fluid (PF) components identified by metabolomics analyses and differentially expressed gene

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Li, Yangshuo, Wei Zhou, Jie Ding, et al. "Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility." Advanced Science, July 22, 2025. https://doi.org/10.1002/advs.202417528.

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AbstractEndometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE‐associated infertility (OEI). A single‐cell atlas of pre‐ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron‐induced senescence phenotypes. Spatial transcriptomics using Stereo‐seq in iron‐overloaded mouse ovaries further identifies localized senesce

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Patel, Harshit, Hetal Solanki, Sohilkhan R. Pathan, Kruti B. Sharma, and Vishal A. Patel. "Etiology and Treatment of Infertility in Tertiary Care Center of Anand, Gujarat, India." Research Journal of Pharmacology and Pharmacodynamics, May 29, 2024, 80–84. http://dx.doi.org/10.52711/2321-5836.2024.00014.

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This study sought to investigate the etiology and risk factors contributing to infertility, assess the efficacy of fertility-inducing drugs, and analyze the treatment modalities' impact on the quality of life for infertile patients. Spanning a 6-month duration, the research incorporated 50 patients, and risk factors were discerned through a tailored case report form reflecting daily routines and habits. A comparative analysis of Letrozole, Clomiphene citrate, and Metformin was conducted based on existing literature. Predominant causes of female infertility encompassed tubal factors, ovulatory

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