Academic literature on the topic 'Endoscopic photodynamic therapy'

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Journal articles on the topic "Endoscopic photodynamic therapy"

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Jacobs, TM, and GM Rosen. "Photodynamic therapy as a treatment for esophageal squamous cell carcinoma in a dog." Journal of the American Animal Hospital Association 36, no. 3 (2000): 257–61. http://dx.doi.org/10.5326/15473317-36-3-257.

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Intrathoracic esophageal squamous cell carcinoma was diagnosed by endoscopy in an 11-year-old, castrated male Labrador retriever with signs of regurgitation and weight loss. Photodynamic therapy with photofrin was administered three times under endoscopic guidance over a two-month period. A partial response to photodynamic therapy was supported by a reduction in tumor size (noted on serial endoscopic examinations) and by a return to oral alimentation. The dog was euthanized due to recurrent regurgitation and aspiration pneumonia nine months after the onset of therapy. Necropsy revealed marked local invasiveness and regional lymph node metastasis of the esophageal squamous cell carcinoma in addition to pneumonia. The application of photodynamic therapy in the treatment of canine esophageal squamous cell carcinoma is discussed and compared with the human literature.
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Gossner, L. "Photodynamic Therapy: Esophagus." Canadian Journal of Gastroenterology 16, no. 9 (2002): 642–44. http://dx.doi.org/10.1155/2002/918694.

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Photodynamic therapy (PDT) is a minimally invasive, organ-preserving therapeutic modality, involving three separate components - light, oxygen and a photosensitizing drug. The principles of PDT are described, and the indications for its use are reviewed. Although a widespread clinical application for PDT has not yet emerged, PDT may establish itself as an endoscopic procedure with few or no side effects in the treatment of Barrett’s esophagus (high-grade dysplasia and early carcinoma) and, in selected cases, for the treatment of early squamous cell carcinoma.
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Kameya, Akira, Yoshiaki Ito, Tomoyuki Kano, et al. "Endoscopic photodynamic therapy of colonic adenoma." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 7, no. 3 (1987): 97–98. http://dx.doi.org/10.2530/jslsm1980.7.3_97.

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Wilson, Brian C. "Photodynamic Therapy for Cancer: Principles." Canadian Journal of Gastroenterology 16, no. 6 (2002): 393–96. http://dx.doi.org/10.1155/2002/743109.

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The principles of photodynamic therapy (PDT), using drugs (photosensitizers) that are activated by light to become cytotoxic, provide the basis for understanding the current and potential future clinical applications in gastroenterology, general oncology and other specialities. The properties of photosensitizers are key to their biological efficacy, while lasers and optical fibres allow convenient and flexible light delivery for endoscopic use. PDT has several distinct and unique advantages, both as a stand-alone treatment and in combination with other established modalities. The current limitations are also recognized, as is the need for rigorous randomized trials of this emerging technology. The fluorescence of many photosensitizers may be useful, either for (endoscopic) diagnosis or for PDT treatment guidance and monitoring.
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Okushima, Norihiko, Hiroko Ide, Shigeru Suzuki, and Fujio Hanyuu. "Endoscopic photodynamic therapy for esophageal cancer." Nihon Kikan Shokudoka Gakkai Kaiho 40, no. 2 (1989): 118–21. http://dx.doi.org/10.2468/jbes.40.118.

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Ito, Yoshiaki, Hiroshi Sugiura, Akira Kameya, et al. "Endoscopic photodynamic therapy of stomach tumors." JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 6, no. 3 (1986): 187–90. http://dx.doi.org/10.2530/jslsm1980.6.3_187.

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Meier, Benjamin, and Karel Caca. "Endoscopic and Photodynamic Therapy of Cholangiocarcinoma." Visceral Medicine 32, no. 6 (2016): 411–13. http://dx.doi.org/10.1159/000453540.

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Barr, Hugh, Catherine Kendall, Florian Bazant-Hegemark, and Nicholas Stone. "Endoscopic photodynamic therapy for oesophageal disease." Photodiagnosis and Photodynamic Therapy 3, no. 2 (2006): 102–5. http://dx.doi.org/10.1016/j.pdpdt.2006.03.008.

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Spinelli, Pasquale, and Marco Dal Fante. "Endoscopic photodynamic therapy in lung cancer." Lasers in Medical Science 5, no. 2 (1990): 181–83. http://dx.doi.org/10.1007/bf02031379.

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Luzzi, Anna, and Giuseppe Tortora. "An Intelligent Wired Capsule for the Treatment of Helicobacter pylori." Applied Sciences 12, no. 1 (2021): 28. http://dx.doi.org/10.3390/app12010028.

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An endoscopic capsule is a miniaturized ingestible video camera used to acquire images of the gastrointestinal tract wirelessly. Being morphologically equivalent to any ingestible pill, they can be simply swallowed. Endoscopic capsules therefore present an inviting alternative to the traditional endoscope for the examination of the gastrointestinal tract as well for therapeutic purposes. Endoscopic capsules are considered a disruptive technology, as they have revolutionized the examination of the gastrointestinal tract in a relatively short time. The implementation of an active locomotion system can improve the performance of a capsule and, in the solution proposed in this paper, allows providing the capsule the needed power for therapeutic purposes. Alternative therapeutic solutions, based on optical solutions and capsule endoscopy can be applied to patients affected by Helicobacter pylori, a bacterium of the stomach that affects about half of the world population, mainly in developing countries. The infection can be asymptomatic or associated with slight symptomatology. In some cases, it can take to major pathologies or death. The literature reports results deriving from recent applications of photodynamic treatments to H. pylori. Specific wavelengths have been found to exhibit photo-killing capabilities toward the bacterium. Some solutions have been proposed based on the use of endoscopic devices and capsules capable of administering photodynamic therapy inside the stomach. The proposed treatments, however, are invasive and insufficient to achieve long-term eradication. In this work, the administration of photodynamic therapy is proposed, aimed at the eradication of H. pylori by means of an active endoscopic capsule with LED emission. The capsule design, in addition to the therapeutic module aimed at administering an appropriate light intensity at specific wavelengths already demonstrated in the literature, integrates an active locomotion system aimed at maximizing the efficiency of the treatment.
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Dissertations / Theses on the topic "Endoscopic photodynamic therapy"

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Gounella, Rodrigo Henrique. "Módulo fotônico para terapia fotodinâmica (PDT) em cápsulas endoscópicas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-13122018-161527/.

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A cápsula endoscópica é um instrumento revolucionário, que permite a realização de um exame livre de desconfortos para o paciente e possibilitou a técnica de endoscopia chegar a partes do sistema gastrointestinal que antes não era possível, como grande parte do intestino delgado. Este trabalho apresenta um módulo fotônico para realizar Terapia Fotodinâmica (PDT, Photodynamic Therapy) em cápsulas endoscópicas. A PDT é uma forma de tratamento para lesões que envolve a administração prévia de um medicamento fotossensível (PS, Photosensitizer) e posterior ativação com irradiação de luz em um comprimento de onda (&#955;) específico. Geralmente para a ativação do PS utiliza-se &#955; na região vermelha do espectro visível, pois a penetração nos tecidos é elevada. Células de adenocarcinoma gástrico humano (AGS, Adenocarcinoma Gastric of Stomach) foram preparadas com ácido 5-aminolevulínico (5-ALA) que é um Pró-fármaco precursor do agente fotossensível Protoporfirina IX (PpIX) com máximo de absorção nos 635 nm. Para realizar a irradiação com luz vermelha nas células, 16 LEDs do modelo LRQ396-P1Q2-1 da Osram Opto Semiconductors com dimensões muito reduzidas foram selecionados, caracterizados, montados em uma PCB (Printed Circuit Board) e alimentados por um Arduino Mega 2560. Este sistema de iluminação foi eficaz em seu propósito e causou morte celular nas células submetidas ao tratamento com o ALA em uma concentração de 2 milimol por litro e dose de luz em 5 Joules por centímetro quadrado que resulta em uma exposição de 49 minutos. Com o objetivo de se construir um módulo para controle de iluminação em cápsulas endoscópicas, foi desenvolvido em tecnologia CMOS 0.7 &#956;m da ON Semiconductor um dispositivo capaz de controlar a intensidade dos LEDs utilizando PWM (Pulse Width Modulation). Unindo este componente com os LEDs selecionados é perfeitamente possível construir o módulo e inseri-lo CEs para realizar PDT em locais do trato gastrointestinal (GI) não acessíveis pela endoscopia convencional.<br>The endoscopic capsule is a revolutionary instrument that gives a free examination of discomforts for patient and allows the endoscopic technique to reach parts of the gastrointestinal system that were previously not possible, such as a large part of the small intestine. This work presents a photonic module to perform Photodynamic Therapy (PDT) in endoscopic capsules. PDT is a form of treatment for injuries involving prior administration of a photosensitive drug (PS, Photosensitizer) and subsequent activation with light irradiation at a specific wavelength (&#955;). Usually for PS activation, &#955; is used in the red region of the visible spectrum, because the tissue penetration is high. Human gastric adenocarcinoma cells (AGS) were prepared with 5-aminolevulinic Acid (5-ALA) which is a Pro-drug precursor of the photosensitive agent Protoporphyrin IX (PpIX) with maximum absorption at 635 nm. To perform red light irradiation on the cells, 16 LEDs, model LRQ396-P1Q2-1 of the Osram Opto Semiconductors with very small dimensions were selected, characterized, mounted on a PCB (Printed Circuit Board) and powered by an Arduino Mega 2560. This system was effective in its purpose and caused cell death in cells treated with ALA at a concentration of 2 mMol/L and dose of light at 5 J/cm² resulting in a 49 minutes exposure. With the objective of build a module for control of lighting in endoscopic capsules, a device able to controlling the intensity of the LEDs using PWM (Pulse Width Modulation) was developed in CMOS technology 0.7 &#956;m of the ON Semiconductor. Combining this component with the selected LEDs, it is perfectly possible to construct the module and insert in CEs to perform PDT at sites of the gastrointestinal tract (GI) not accessible by conventional endoscopy.
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Book chapters on the topic "Endoscopic photodynamic therapy"

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Manta, Raffaele, Dolores Sgambato, Nico Pagano, and Giuseppe Galloro. "Endoscopic Treatments: Photodynamic Therapy." In Revisiting Barrett's Esophagus. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92093-1_13.

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Kato, Harubumi, Kinya Furukawa, Yasufumi Kato, Jitsuo Usuda, Kuniharu Miyajima, and Keishi Ohtani. "20 Endoscopic imaging and photodynamic therapy." In Imaging in Photodynamic Therapy. CRC Press, 2017. http://dx.doi.org/10.1201/9781315278179-21.

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Spinelli, P., M. Dal Fante, and A. Mancini. "Endoscopic Photodynamic Therapy: Clinical Aspects." In NATO ASI Series. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-7287-5_16.

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Okushima, N., M. Yoshida, H. Fukui, et al. "Endoscopic Photodynamic Therapy for Esophageal Cancer." In Diseases of the Esophagus. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-86432-2_162.

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Muthusamy, V. Raman, and Kenneth J. Chang. "Photodynamic Therapy (PDT): The Best-Validated Technique." In Endoscopic Therapy for Barrett's Esophagus. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-445-6_8.

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Ibrahim, Tommy, and Michel Kahaleh. "Photodynamic Therapy: Palliation and Endoscopic Technique in Cholangiocellular Carcinoma." In Frontiers of Gastrointestinal Research. KARGER, 2009. http://dx.doi.org/10.1159/000258385.

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Tsuchida, Takaaki, and Takehiro Izumo. "Photodynamic Therapy for Lung Cancer." In Respiratory Endoscopy. Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-287-916-5_29.

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Hayata, Yoshihiro, and Jutaro Ono. "Photodynamic Therapy in Early Stage Carcinoma." In Medical Laser Endoscopy. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0507-8_25.

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Gilbertson, Jeffrey J., and John A. Dixon. "Photodynamic Therapy: Basic Aspects and Tissue Interaction." In Medical Laser Endoscopy. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0507-8_24.

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Baas, Paul. "Photodynamic Therapy in the Pleural Space." In Thoracic Endoscopy: Advances in Interventional Pulmonology. Blackwell Publishing, 2008. http://dx.doi.org/10.1002/9780470755969.ch16.

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Conference papers on the topic "Endoscopic photodynamic therapy"

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Xiao, Linlin, Tingbi Zhao, and Ruoping Li. "Experience with endoscopic laser polypectomy in stomach and intestine: a 214-case report." In International Conference on Photodynamic Therapy and Laser Medicine, edited by Junheng Li. SPIE, 1993. http://dx.doi.org/10.1117/12.137048.

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Kuvshinov, Yury P., Boris K. Poddubny, Andrei F. Mironov, et al. "Endoscopic photodynamic therapy of tumors using gold vapor laser." In CIS Selected Papers: Laser Use in Oncology, edited by Andrei V. Ivanov and Mishik A. Kazaryan. SPIE, 1996. http://dx.doi.org/10.1117/12.229488.

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Kawaguchi, Minoru, Ge Er-Jie, Kimitoshi Shitijou, and Toshihiko Saito. "Fundamental and clinical studies of endoscopic Nd:YAG laser balloon irradiation for early gastric cancer." In International Conference on Photodynamic Therapy and Laser Medicine, edited by Junheng Li. SPIE, 1993. http://dx.doi.org/10.1117/12.136980.

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Doiron, Daniel R. "Diode Laser Systems for Photodynamic Therapy." In Semiconductor Lasers: Advanced Devices and Applications. Optica Publishing Group, 1995. http://dx.doi.org/10.1364/slada.1995.mc.5.

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Diode lasers have long been viewed as the future technology for clinical light sources for use in Photodynamic Therapy (PDT). This has been based on their small size, high efficiency, potential reliability and potential low cost. The requirement for a laser source in PDT is based on their ability to deliver light efficiently through small single optical fibers. This in turns allows for endoscopic and interstitial use. The wavelength of the diode source must match that of the absorption of the photosensitizer used, which are chosen to provide good tissue penetration. Due to the high tissue penetration requirements wavelengths in the red and near infrared are used. At present the photosensitizers in clinical testing and commercial development have peak absorptions in the 630nm to 695nm range, while preclinical testing includes photosensitizers with absorption extending up to 800nm. Above 800nm the photophysics of the compounds tend to make them less desirable for use in PDT. The accuracy and stability of the center wavelength of the light source, and its bandwidth, must match to the action spectrum of the photosensitizer in-vivo. For example the first generation photosensitzer Photofrin® activation is specified as 630+/-3nm while for the second generation photosensitizer SnET2 it is 664+/-7nm.
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Tian, Mao-en, Fa-wen Liu, Jia-ping Qian, Qing Ji, and Yun-qiu Feng. "Endoscopic photodynamic therapy with hematoporphyrin derivative in the treatment of malignant tumors: report of 120 cases." In International Conference on Photodynamic Therapy and Laser Medicine, edited by Junheng Li. SPIE, 1993. http://dx.doi.org/10.1117/12.136999.

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Corti, Luigi, Lamberto Toniolo, Caterina Boso, et al. "Endoscopic treatment of early bronchial cancer: our experience with photodynamic therapy (PDT)." In 12th World Congress of the International Photodynamic Association, edited by David H. Kessel. SPIE, 2009. http://dx.doi.org/10.1117/12.834015.

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Spinelli, Pasquale, Marco Dal Fante, and Andrea Mancini. "Is photodynamic therapy a selective treatment? Analysis of local complications after endoscopic photodynamic therapy of early stage tumors of gastrointestinal, tracheobronchial, and urinary tracts." In Fifth International Photodynamic Association Biennial Meeting, edited by Denis A. Cortese. SPIE, 1994. http://dx.doi.org/10.1117/12.203363.

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Woodward, Timothy A., and Herbert C. Wolfsen. "Photodynamic therapy (PDT) with endoscopic ultrasound for the treatment of esophageal cancer." In BiOS 2000 The International Symposium on Biomedical Optics, edited by R. Rox Anderson, Kenneth E. Bartels, Lawrence S. Bass, et al. SPIE, 2000. http://dx.doi.org/10.1117/12.386281.

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Meerovich, Gennadii A., Victor B. Loschenov, Alexander A. Stratonnikov, et al. "Laser fluorescent system for endoscopic tumor diagnostic and irradiation control in photodynamic therapy." In BiOS Europe '95, edited by Rinaldo Cubeddu, Serge R. Mordon, and Katarina Svanberg. SPIE, 1995. http://dx.doi.org/10.1117/12.228891.

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Meerovich, Gennadii A., Victor B. Loschenov, Alexander A. Stratonnikov, et al. "Laser fluorescent system for endoscopic tumor diagnostic and irradiation control in photodynamic therapy." In CIS Selected Papers: Laser Use in Oncology, edited by Andrei V. Ivanov and Mishik A. Kazaryan. SPIE, 1996. http://dx.doi.org/10.1117/12.229494.

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