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Dissertations / Theses on the topic 'Endosome'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Stroud, Evelyn Joy. "Kinetic analysis of endosome processing : maturation of early endosomes and vesicular traffic to lysosomes." Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27043.

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The present study was undertaken to establish the mechanism(s) involved in the endocytic pathway, in particular, early endosome processing and delivery to the lysosomes. Two models for endosome processing have previously been proposed in the literature, namely the maturation and vesicular traffic models. The general consensus has been an early phase of intermingling of the endocytic contents markers within early endosomes that mature to form non-fusogenic late endosomes (maturation model). This maturation phase is followed by a segregation phase where intermingling of contents between vesicles
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2

Stimpson, Helen Elizabeth Margaret. "Sorting into the yeast endosome." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615138.

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3

Legalatladi, Seetsela. "The kinetics of endosome processing." Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27047.

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The present thesis looks at the behaviour of internalised cell surface-derived membrane marker in comparison with the behaviour of endocytosed HRP (horse-radish peroxidase) as a fluid-phase contents marker. The pooling and/or segregation in the endosome was measured by determining co-localization with HRP. Colocalization of the two markers in the endosome is studied by using the ability of HRP to catalyse the crosslinking of membrane marker in endosomes with DAB (3,3'-diaminobenzidine), rendering the membrane marker detergent insoluble. To study the kinetic behaviour of membrane marker, radioa
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4

McKenzie, Jenna Elyse. "The recycling endosome is required for transport of retrograde toxins." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/406.

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Shiga toxin and cholera toxin are members of the AB5 family of protein exotoxins. The A subunit is the enzymatic subunit, whereas the pentameric B subunit binds cell surface receptors and carries the A subunit to the endoplasmic reticulum (ER) where it can be released into the cytosol. The B-subunits (STxB or CTxB) mediate toxin traffic along the retrograde pathway from the plasma membrane to the ER via early/recycling endosomes and the Golgi apparatus. It is unknown if STxB requires transport through the Golgi, or if it is just kinetically favorable. It is also unknown if the recycling endoso
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5

Hernández, Pérez Inés. "Kazrin C Controls Endocytic Trafficking and is a Double Regulator of Actin Polymerisation and Microtubule Transport." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671167.

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Les cèl·lules eucariotes internalitzen i redistribueixen les molècules de la superfície a través de la ruta endocítica. Aquest és un procés clau per a l’adquisició de nutrients i el catabolisme que també controla l’exposició de receptors i complexos d’adhesió cel·lular, entre d’altres. Treballs anteriors del nostre laboratori van identificar la kazrina C com una proteïna que bloquejava l’endocitosi depenent de clatrina (CME) quan es sobreexpressava. El treball exposat a aquesta tesi confirma el paper de la kazrina en CME, ja que les cèl·lules KO de kazrina generades pel sistema de CRISP
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6

Schuster, Martin. "Motor cooperation in bi-directional early endosome motility." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3169.

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In mammalian cells and fungi, early endosomes form a dynamic compartment that undergoes bi-directional motility along microtubules. Previous work has shown that in the model system Ustilago maydis early endosome motility involves the opposing motor proteins dynein and kinesin-3. Here I performed a detailed analysis of the role of the motors in early endosome motility, using quantitative live cell imaging of kinesin-3, dynein and the endosomal GTPase Rab5a. In the first part of my work, I analysed the role of dynein at MT plus-ends, where the motor forms a strong accumulation that was thought t
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7

Cook, N. R. "Reconstitution of TGN to endosome transport in vitro." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597930.

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The trans-Golgi network (TGN) is one of the major intracellular membrane sorting stations in the cell. Here a number of specific proteins are segregated from the pathway of constitutive secretion and transported to a variety of membrane bound organelles. It is thought that newly synthesised lysosomal components are sorted here for delivery to the endocytic pathway. Examples of such proteins are a number of highly glycosylated integral membrane proteins enriched in the limiting membrane of lysosomes. The majority of these proteins are believed to reach this compartment by direct transport from
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8

Senic-Matuglia, Francesca. "RAB11, une petite GTPase des endosomes de recyclage : étude de trois de ses partenaires et de son rôle dans la mélalogénèse." Paris 11, 2002. http://www.theses.fr/2002PA112220.

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Rab 11 est une GTPase principalement associée au compartiment endosomal de recyclage (ERC) où elle joue un rôle d'organisateur de ces membranes. Dans les cellules Mnt1, Rab11 colocalise partiellement avec la forme immature de Pmel17, une protéine de la matrice mélanosomale. La surexpression de Rab11wt et Q70L perturbe la distribution de la forme mature de Pmel17 et induit une diminution de la mélanine intracellulaire. Nous avons démontré que Rab11 joue un rôle dans la maturation de Pmel17, puisque le mutant Q70L induit une accumulation d'une de ses formes précurseurs. De plus, Rab11 interagit
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9

Barres, Céline. "La galectine-5 associée aux exosomes de réticulocyte de rat : caractérisation et étude fonctionnelle." Montpellier 2, 2009. http://www.theses.fr/2009MON20098.

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Lors de sa maturation en érythrocyte, le réticulocyte sécrète de petites vésicules membranaires appelées exosomes. Les exosomes sont les vésicules intraluménales des endosomes multivésiculaires libérées dans le milieu extracellulaire lors de la fusion de ces compartiments endosomaux avec la membrane plasmique. Cette voie de sécrétion contribue au remodelage de la membrane plasmique durant l'érythropoïèse en éliminant spécifiquement certaines protéines membranaires. Le travail présenté dans cette thèse porte sur la caractérisation et la fonction de la galectine-5 au cours de la maturation du ré
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10

Apfeldorfer, Coralie. "Lysosome biogenesis during osteoclastogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1164801444532-19433.

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Lysosomes are acidic, hydrolase-rich vesicles capable of degrading most biological macromolecules. During the past several decades, much has been learned about different aspects of lysosome biogenesis. The selective phosphorylation of mannose residues on lysosomal enzymes, in conjunction with specific receptors for the mannose-6-phosphate recognition marker, has been found to be largely responsible for the targeting of newly synthesized lysosomal enzymes to lyzosomes. It is known that lysosomes receive input from both the endocytotic and biosynthetic pathways. Nevertheless the exact molecular
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11

Reddy, Jonathan Venkat. "The role of Vps26p in endosome to golgi retrieval." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620440.

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12

Shah, Ankur H. "Adenovirus RIDalpha Regulates Endosome Maturation by Mimicking GTP-Rab7." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1181051279.

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13

Zanin, Natacha. "Role de STAM dans la régulation endosomale de la signalisation JAK/STAT induite par les IFNs." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS047.

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La première implication des récepteurs aux interférons de type 1 (IFNAR1) dans le contrôle de la voie Jak/STAT induite par les IFNs a été établie par mon laboratoire il y a une dizaine d'années (Marchetti et al., 2006). Une des questions fondamentales était alors de déterminer comment et pourquoi l'endocytose des IFNARs pouvait contrôler la voie Jak/STAT. Deux acteurs clés du tri endosomal ont attiré notre attention : Hrs (Hepatocyte growth factor-Regulated tyrosine kinase Substrate) et STAM (Signal Transducing Adaptor Molecule). Ces deux protéines constituent le complexe ESCRT-0 (Endosomal So
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14

Höpfner, Sebastian. "Modulation of Cargo Transport and Sorting through Endosome Motility and Positioning." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1132927530983-53598.

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Utilizing various systems such as cell-based assays but also multicellular organisms such as Drosophila melanogaster and C.elegans, for example, the endocytic system has been shown to consist of a network of biochemically and morphologically distinct organelles that carry out specialized tasks in the uptake, recycling and catabolism of growth factors and nutrients, serving a plethora of key biological functions (Mellman, 1996). Different classes of endosomes were found to exhibit a characteristic intracellular steady state distribution. This distribution pattern observed at steady state result
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15

McKenzie, Jenna Elyse Sheff David R. "The recycling endosome is required for transport of retrograde toxins." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/406.

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16

Mercier, Vincent. "Etude du rôle de la protéine Alix dans l'endocytose." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV059/document.

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L’endocytose est le processus qui permet l’entrée, dans la cellule, de portions de la membraneplasmique ainsi que du milieu extracellulaire et des substances qu’il contient. Ces dernièresannées, plusieurs mécanismes d’endocytose ont été identifiés, mais la voie médiée par la clathrine(CME) reste la mieux caractérisée à l’heure actuelle. Au cours de ce travail, nous nous sommesintéressés à Alix, une protéine adaptatrice qui s’associe avec de nombreux partenaires de la voieendolysosomale mais dont le rôle dans l’endocytose reste encore peu connu. Ce travail derecherche a pour objectif de mieux c
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17

Gandhi, Hetvi. "Early events in cytokine receptor signaling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135614.

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Ligand-activated signal transduction is a process critical to cell survival and function as it serves as a means of communication between the cells and their environment. Endocytosis is generally thought to down-regulate incoming signals by reducing the surface availability of receptors. However, increasing evidence in many systems suggests a notion which is referred to as the „signalling endosome" hypothesis - that endocytosis can also actively contribute to signalling apart from clearance of activated receptors and thereby attenuation of signalling. The functional aspect of signalling endoso
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18

Dawson, Jonathan Edward. "Dynamics of endosomal trafficking." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-90216.

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Endosomes are dynamic vesicular structures which transport cargo molecules internalized into the cell via endocytosis. Endosomal trafficking of cargo involves a large number of individual endosomes that regularly interact with each other via fusion and fission and thus form a dynamic network wherein endocytosed cargo is sorted and transported to various other intracellular compartments. In this study we present a general theoretical framework that takes into account individual endosomes and several key microscopic interaction processes among them. By combining theory with quantitative experime
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19

Inamdar, Shivangi Makarand. "Dab2 plays a role in the post-endocytic trafficking of VEGFR2." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2225.

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Angiogenesis is a crucial process under both physiological and pathological conditions. Vascular endothelial growth factor (VEGF) A and its cognate receptor, vascular endothelial growth factor receptor 2 (VEGFR2) are key regulators of angiogenesis. Plasma membrane (PM) levels of VEGFR2 are regulated by de novo synthesis, and by both exocytic and endocytic trafficking. VEGF-binding to VEGFR2 induces phosphorylation of key tyrosine residues located in the cytosolic domain of the receptor, followed by clathrin-mediated endocytosis and signal transduction leading to vascular morphogenesis. Disable
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20

Chandrashaker, Akhila. "Systems analysis of early endosome motility through identification of molecular motors." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-61594.

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Endocytosis is an evolutionary conserved process of internalization of cargo from the extracellular environment, be they ligands, nutritional and signaling or pathogens into cells. Following their entry, cargo is received into vesiculo-tubular network of early endosomal compartments from where they are sorted and routed to appropriate cellular destinations through transport along the endocytic network. Recycling cargo is sorted away from other cargo resident in early endosomes through tubulation resulting in fission of recycling vesicles, while those to be degraded are progressively concentrat
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21

Boucherit, Nicolas. "Mécanisme d'interférence de la conversion du phagosome par Coxiella burnetii." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5061/document.

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Pour survivre et se multiplier dans leurs cellules hôtes les bactéries intracellulaires ont élaboré divers mécanismes d'échappement à la réponse immunitaire. L’altération du trafic intracellulaire est une des stratégies utilisée par ces agents pathogènes. Ainsi Coxiella burnetii, bactérie intracellulaire stricte responsable chez l’homme de la fièvre Q, bloque la maturation du phagosome afin de résider et se multiplier dans un compartiment incapable de fusionner avec les lysosomes. Ce défaut de fusion est associé à la virulence bactérienne. Pour analyser le défaut de maturation du phagosome de
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22

Santambrogio, Martina. "Role of the retromer complex and its interactors in Arabidopsis development." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10346.

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Chez la levure et les mammifères le complexe rétromère est impliqué dans différentes étapes de trafic intracellulaire qui modulent divers processus cellulaires et développementaux. Chez les mammifères, le rétromère se compose des protéines Vacuolar Protein Sorting (VPS) 35, VPS26, VPS29 et d’un dimere de Sorting Nexins (SNX). Les composants du rétromère sont conservés chez les plantes et sont localisés dans le même endosome de tri. Dans ce travail, nous avons étudié le mécanisme d’assemblage et de recrutement du complexe à la membrane et analysé le rôle du rétromère dans le développement d’Ara
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23

Gallon, Matthew. "A molecular analysis of endosome to plasma membrane recycling mediated by retromer." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685044.

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The endosomal network is a crucial hub in the trafficking of proteins through the cellular endomembrane system. Cargo proteins enter endosomes by endocytosis from the plasma or by trafficking from the trans-Golgi network (TGN). Here, cargo proteins face one of two fates: retention in the endosome, leading ultimately to lysosomal degradation, or export from the endosome for re-use ("recycling"). The balance of protein degradation and recycling is crucial to cellular homeostasis; inappropriate sorting of proteins to either fate leads to cellular dysfunction. Retromer is an endosome-membrane-asso
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24

Wang, Xiaolin. "Analysis of candidate regulators of TBC-2 and endosome maturation in «Caenorhabditis elegans»." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114348.

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The Rab5 and Rab7 GTPases are key regulators of endosome to lysosome trafficking, whose activities are positively regulated by Rab Guanine nucleotide Exchange Factors and negatively regulated by GTPase Activating Proteins (GAP). In this thesis, the nematode Caenorhabditis elegans was used as a model system to study regulation of Rab GTPase-mediated endosomal trafficking, for simple genetics and easy visualization of organelles under Differential Interference Contrast (DIC) and confocal optics. It was previously demonstrated that TBC-2 functions as a RAB-5 GAP. Loss of tbc-2 activity results i
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25

Aguilar, Quiñones Valeria. "Impact of Viral Geometry and Cellular Lipid Environment on Virus-Endosome Fusion Kinetics." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446545.

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26

Rieder, Stephanie E. "Molecular requirements for protein transport to the endosome and vacuole in saccharomyces cerevisiae /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9824697.

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27

Merithew, Eric Lee. "Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/278.

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As critical regulators of vesicular trafficking, Rab proteins comprise the largest GTPase family, with thirty-eight functionally distinct members and another twenty isoforms in the human genome. Activated Rab GTPases interact with effector proteins involved in vesicle formation, transport, tethering, docking and fusion. The specificity of Rab interactions with effectors and regulatory factors plays a central role with respect to the fidelity of membrane trafficking. Rab recognition determinants and the mechanisms underlying interactions with structurally diverse regulatory factors and effector
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28

井川, 敬介. "Polo-like kinase1はvimentinのリン酸化を介して分裂期において初期エンドソームの膜融合を阻害する". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188844.

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29

Palokangas, H. (Harri). "The role of vacuolar H+-ATPase in exocytic and endocytic membrane transport processes." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514252764.

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Abstract The role of vacuolar H+-ATPase (V-ATPase) in exocytic and endocytic membrane transport processes was studied by using its specific inhibitor, bafilomycin A1 (Baf A1), as a tool. On the exocytic pathway, both brefeldin A- and nocodazole-induced retrograde transport of Golgi proteins to the endoplasmic reticulum (ER) were inhibited by Baf A1. Furthermore, p58/ERGIC-53, which normally cycles between the ER, the intermediate compartment (IC), and cis-Golgi, was arrested in pre-Golgi tubules and vacuoles, and the number of p58-positive 80-nm Golgi (COPI) vesicles was reduced, sugge
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30

Peterson, Michael Ross. "Characterization of the molecular mechanisms which regulate Golgi-to-endosome vesicular transport in Saccharomyces cerevisiae /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3013698.

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31

Simonetti, Boris. "A molecular analysis of tubular-based cargo recycling by the endosome-associated SNX-BAR proteins." Thesis, University of Bristol, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738299.

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32

Sandilands, Emma. "RhoB and actin polymerisation co-ordinate c-Src activation with endosome mediated delivery to the membrane." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422486.

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33

Dukes, Joseph Donaldson. "Investigating the link between phosphoinositides, endosomal trafficking and ESCRT function." Thesis, University of Bath, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512257.

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The maturation of early endosomes into multivesicular bodies (MVBs) and subsequent trafficking to lysosomes is an important event for the control and silencing of endocytosed membrane receptors. The endosomal-sorting complex required for transport (ESCRT) proteins appear to play a key role in this event. Phosphatidylinositol lipids including PtdIns(3,5)P2 have been implicated in the MVB-lysosomal pathway and an ESCRT-III component CHMP3 binds to this lipid in vitro. The purpose of this thesis was to investigate the link between ESCRT proteins, PtdIns(3,5)P2 and endo-lysosomal trafficking. Firs
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34

Roy, Simon. "Régulation fonctionnelle du récepteur de l'ACTH, MC2R." Thèse, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5811.

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L'ACTH stimule son récepteur au niveau du cortex surrénalien afin d'enclencher la synthèse et la sécrétion de cortisol chez l'humain.L'hypothèse du projet propose qu'il existe une régulation moléculaire de MC2R (melanocortin-2 receptor) qui permet les [i.e. aux] cellules corticosurrénaliennes de s'adapter aux variations physiologiques d'ACTH. Mon projet de doctorat a consisté à utiliser MC2R et MRAP (MC2R accessory protein) recombinés dans les cellules embryonnaires de rein humain (HEK) 293/FRT (Flp recombinase target). J'ai développé ce modèle entièrement humain afin de contourner les problèm
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35

Jozic, Ivan. "Selective and Specific Activation of Rab5 during Endocytosis of Receptor Tyrosine Kinases." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/813.

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The Rab family of proteins are low molecular weight GTPases that have the ability to switch between GTP- (active) and GDP- (inactive) bound form, and in that sense act as molecular switches. Through distinct localization on various vesicles and organelles and by cycling through GTP/GDP bound forms, Rabs are able to recruit and activate numerous effector proteins, both spatially and temporally, and hence behave as key regulators of trafficking in both endocytic and biosynhtetic pathways. The Rab5 protein has been shown to regulate transport from plasma membrane to the early endosome as well as
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36

Le, Roux Delphine. "Régulation des interactions entre endosomes et cytosquelette pendant la présentation antigénique : un rôle pour la protéine tyrosine kinase Syk." Paris 6, 2006. http://www.theses.fr/2006PA066472.

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37

Dagdas, Gulay. "Studies on peroxisome motility in the model fungal system Ustilago maydis." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/17403.

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Peroxisomes are ubiquitous organelles found in almost all eukaryotes. They are sensitive to changes in cellular homeostasis and involved in various metabolic processes. Deficiencies in peroxisome function cause severe neurological problems. Here I report, investigation of peroxisome motility and its relation to peroxisomal functions in the fungal model system Ustilago maydis. Peroxisomes are mostly motile in Ustilago maydis. Motile peroxisomes show different motility patterns: short-range pulse type movements and long range bidirectional motility. Motility behaviour is not static as oscillatin
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38

Stringer, Daniel Kenneth. "The role of ubiquitination within the endocytic pathway." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/2775.

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Ubiquitination is a post-translational modification tht mediates sorting of integral membrane proteins to lysosomes for their degradation. ESCRTs (Endosomal Sorting Complex Required For Transport) bind and sequester ubiquitinated membrane proteins and direct them into multivesicular bodies (MVBs). ESCRTs themselves become covalently ubiquitinated, simply by virtue of non-covalently binding Ub. However, it is unclear whether this regulates a critical aspect of ESCRT function. In yeast, many MVB cargo proteins are ubiquitinated by the HECT-type Ub-ligase Rsp5, sometimes via the action of Rsp5 ad
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39

Sangare, Lamba Omar. "Le compartiment endosomale (ELC) non conventionnel et le complexe rétromère gouvernent l'intégrité du parasite et l'infection de l'hôte." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S034/document.

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Toxoplasma gondii, comme Plasmodium falciparum appartiennent au phylum des Apicomplexes. Ce groupe de parasites ont comme dénominateurs communs, trois organites apicaux : rhoptries, micronèmes et granules denses contenant des facteurs indispensables pour la reconnaissance, l’entrée et la survie du parasite au sein de la cellule hôte. Le récepteur transmembranaire de type 1 appelé TgSORTLR ("Toxoplasma gondii Sortilin-Like Receptor") est nécessaire à la biogenèse des organelles de sécrétion rhoptrie et micronème (Sloves et al., 2012). Le domaine C-terminale de la TgSORTLR, lie TgVps26 et TgVps3
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40

Nickerson, Daniel Patrick. "The function of the ATPase Vps4 in multivesicular body cargo sorting and endosome morphology in Saccharomyces cerevisiae." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337060.

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41

Baker, Bianca Nicole. "Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/56732.

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The gram-negative endotoxin, lipopolysaccharide (LPS), has been extensively researched in high doses (10-200ng/ml) and is well-documented in the literature for its ability to result in devastating effects such as multi-organ failure, sepsis, and septic shock. In high doses, LPS signals through Toll-like-receptor 4 (TLR4) and triggers a cascade of events culminating in the release of pro- and anti-inflammatory cytokines and the activation of NF-κB. In contrast, super-low doses of LPS (1-100pg/ml) are able to trigger the persistent release of pro-inflammatory mediators while evading the compensa
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42

Bakr, May. "Role of vSNAREs in post-synaptic AMPAR trafficking, glutamatergic transmisson and plasticity." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0323.

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La plasticité synaptique, c'est-à-dire la modification de la force synaptique en fonction de l'activité, est une caractéristique remarquable du système nerveux et été considérée depuis longtemps comme la base cellulaire de l'apprentissage et de la mémoire. Une forme bien caractérisée de plasticité synaptique est la potentialisation à long terme (PLT) de la transmission synaptique excitatrice dans les neurones pyramidaux de la région CA1 de l'hippocampe. La PLT nécessite le recrutement et la stabilisation rapides des récepteurs α-amino-3-hydroxy-5-méthyl-4-isoxazolepropionate (AMPAR) sur les si
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43

Mountz, Adele K. "The synthesis, characterization, and use of a protein-cysteine proteinase inhibitor complex for the study of endosome/lysosome fusion." Diss., Virginia Tech, 1994. http://hdl.handle.net/10919/38555.

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Scholl, Stefan [Verfasser], and Karin [Akademischer Betreuer] Schumacher. "pH in the trans-Golgi network/early endosome of Arabidopsis thaliana: Suppliers and consumers / Stefan Scholl ; Betreuer: Karin Schumacher." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177251434/34.

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Scholl, Stefan Verfasser], and Karin [Akademischer Betreuer] [Schumacher. "pH in the trans-Golgi network/early endosome of Arabidopsis thaliana: Suppliers and consumers / Stefan Scholl ; Betreuer: Karin Schumacher." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177251434/34.

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46

Zwilling, Daniel. "Characterisation of the early endosomal SNARE complex." Doctoral thesis, [S.l.] : [s.n.], 2005. http://webdoc.sub.gwdg.de/diss/2005/zwilling.

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47

Brodeur, Julie. "LRP10 (LDL-related protein 10), un nouveau régulateur du trafic et du clivage de la protéine APP (amyloid precursor protein), est réduit dans la maladie d'Alzheimer." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/5554.

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La maladie d'Alzheimer (MA) est une maladie neurodégénérative progressive et irréversible. Une étape précoce de la MA est la relâche neuronale excessive du peptide amyloïde-[bêta] (A[bêta]), qui s'accumule dans le cerveau, s'assemble et se dépose sous forme de plaques A[bêta] insolubles et neurotoxiques. L'A[bêta] est produit suite au clivage amyloïdogénique de la protéine APP, effectué par les sécrétases [bêta] et [gamma] au niveau des endosomes. Il est bien connu que le trafic intracellulaire de l'APP affecte son clivage. L'étude du trafic intracellulaire de cette protéine est donc cruciale
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48

Rasche, Sarah S. "Processing and Presentation of Glutamic Acid Decarboxylase 65 T cell-Inducing Epitopes: Implications in the Non-Obese Diabetic Mouse Model of Type 1 Diabetes." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1290046839.

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49

Py, Nathalie. "Métalloprotéases matricielles et maladie d'Alzheimer : étude du rôle de MT1-MMP dans le métabolisme de l'APP/Aß." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5073.

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La maladie d'Alzheimer (MA) est la maladie neurodégénérative la plus répandue à travers le monde et reste actuellement incurable. Le peptide beta amyloïde (Abeta), composant principal des plaques séniles retrouvées dans le cerveau des patients, joue un rôle majeur dans le développement de la MA, d'où l'importance de contrôler sa production et/ou son élimination. Dans cette optique, nous travaillons sur des molécules nommées métalloprotéases matricielles (MMPs). Bien qu'ayant été impliquées à la fois dans de nombreux processus physiologiques et pathologiques dans système nerveux, leur rôle dans
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50

Laurent, Olivier. "Reconstitution in vitro des fusions d'endosomes chez Dictyostelium discoideum : mécanismes moléculaires et place dans la voie endocytaire." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10287.

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Le cytoplasme des cellules eucaryotes contient de nombreux compartiments membranaires fermes, capables de fusionner entre eux afin de maintenir leurs proprietes et leur composition. Ces fusions sont etroitement regulees dans le temps et l'espace. Ce manuscrit decrit l'etude des mecanismes moleculaires permettant cette regulation au sein de la voie endocytaire de l'amibe dictyostelium discoideum. Afin de realiser cette etude, un protocole permettant de reconstituer in vitro les fusions des compartiments endocytaires a ete mis au point. Il repose sur le marquage de la voie endocytaire par de la
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