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Dissertations / Theses on the topic 'Endothelin Axi'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

SPINA, CECILIA. "Emerging Evidences for a Protumorigenic Role of the Endothelin Axis Uncover New Therapeutic Targets in Multiple Myeloma." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/144189.

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Multiple Myeloma (MM) is a monoclonal tumor of bone marrow (BM) plasma cell (PC), usually associated with a number of disease manifestations, including skeletal damage, anemia and immunosuppression. Despite recent therapeutic advances and an increased patient life expectancy, MM still remains an incurable malignancy. MM PC is characterized by a strong BM niche dependence, acquiring an autonomous capacity of growth only in the latter stages of disease. The endothelin (ET) axis is mainly composed of Endothelin-1 (ET-1), and 2 G-protein coupled receptors, the ET receptor A (ETAR) and ET recepto

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2

Adner, Mikael. "Altered expression of contractile endothelin receptors in the vascular bed." Lund : Dept. of Internal Medicine, University of Lund, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39103326.html.

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3

Irani, Soussan. "The Endothelin Axis and Angiogenesis in Papillary Thyroid Carcinoma." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/366833.

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Papillary Thyroid Cancer (PTC) is the most common thyroid cancer accounting for 80% of all cases. The prognosis is good, with 5-year survival rates of 95%, but in some cases the tumour behaves in an aggressive manner characterized by local recurrence and/or metastasis, processes contributed to by angiogenesis. Angiogenesis is an essential physiologic activity involved in normal tissue biology and several pathologic conditions such as cardiac failure, and cancer. During carcinogenesis, tumour cells secrete pro-angiogenic factors to initiate angiogenesis. Angiogenesis also causes the migration

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4

Rabura, Sebastian. "Bedeutung der Endothelin-Plasmakonzentration für die Effektivität von inhalativem Stickstoffmonoxid im Modell des akuten Lungenversagens." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-137313.

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Das akute Lungenversagen ist gekennzeichnet durch eine schwere Störung des Gasaustausches mit ausgeprägter arterieller Hypoxämie. Die inhalative Gabe von Stickstoffmonoxid (iNO) erfolgt in der Therapie zur Verbesserung der arteriellen Oxygenierung, der Effekt ist jedoch variabel. Bisher existieren nur wenige Studien zur Identifikation von Faktoren, die die Effektivität von iNO bestimmen. Die positive Wirkung von iNO auf den Gasaustausch lässt eine Vasokonstriktion in beatmeten Lungenarealen vermuten. Wir untersuchten eine mögliche Wechselwirkung zwischen dem endogenen Vasokonstriktor Endotheli

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5

Borrull, Aurélie. "Obtention et caractérisation d’anticorps monoclonaux dirigés contre les récepteurs des endothélines, ETAR et ETBR, surexprimés dans de nombreux cancers et impliqués dans la progression tumorale." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114820/document.

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Il est admis que l’axe endothéline (endothélines ET-1, -2 et -3 et leurs RCPG ETAR et ETBR), participe à la progression tumorale. Alors qu’ETAR est par exemple surexprimé dans le cancer de l’ovaire, ETBR l’est dans le mélanome. Cette surexpression, ainsi que l’implication d’ETA/BR dans la carcinogenèse, font de ces RCPG une cible tumorale pertinente. En raison de leurs forte spécificité, actions cytotoxiques variées, possibilités de couplage, les anticorps monoclonaux (AcM) sont des outils de choix en diagnostic et thérapie anti-cancéreuse. Cependant, on déplore actuellement l’absence d’AcM ci

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6

Allard, Bertrand. "Production et caractérisation d’anticorps polyclonaux et monoclonaux ciblant les récepteurs des endothélines en vue d’une immunothérapie des cancers." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114803/document.

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Le développement des anticorps monoclonaux thérapeutiques est en plein essor notamment à cause de leur bénéfice important pour le traitement des cancers. Cependant, à l’heure actuelle, aucun anticorps monoclonal sur le marché ou en phase III ne cible de RCPGs, en dépit de l’implication grandissante de ces récepteurs dans la carcinogenèse. Parmi les RCPGs les plus pertinents pour l’oncologie, souvent cités dans la littérature et dont certains inhibiteurs chimiques sont en phase clinique avancée, on trouve les deux sous-types de récepteurs des endothélines ETAR et ETBR. Dans ce contexte, mon pro

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7

Miyoshi, Takashi. "The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis." Kyoto University, 2011. http://hdl.handle.net/2433/142065.

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8

Sax, Michael John. "The CCL5-CCR5 Axis in Breast Cancer." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365646.

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Cancer is one of the leading underlying causes of death worldwide. Despite decades of research, cancer is predicted to be the leading cause of death by the year 2020. Anti angiogenic therapies that target the key signalling molecule, vascular endothelial growth factor (VEGF) have shown promise in the treatment of some solid tumours, resulting in increased progression-free survival times in patients. However, there are several significant problems with current anti-angiogenic therapies, such as the phenomenon of resistance. Tumours can be divided into those that are intrinsically nonresponsive

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9

Fang, Jennifer S., Brian G. Coon, Noelle Gillis, et al. "Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification." NATURE PUBLISHING GROUP, 2017. http://hdl.handle.net/10150/626459.

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Establishment of a functional vascular network is rate-limiting in embryonic development, tissue repair and engineering. During blood vessel formation, newly generated endothelial cells rapidly expand into primitive plexi that undergo vascular remodeling into circulatory networks, requiring coordinated growth inhibition and arterial-venous specification. Whether the mechanisms controlling endothelial cell cycle arrest and acquisition of specialized phenotypes are interdependent is unknown. Here we demonstrate that fluid shear stress, at arterial flow magnitudes, maximally activates NOTCH signa

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10

Lindberg, Lars. "Endothelial function during ischemia-reperfusion and effects of inhalation of nitric oxide." Lund : Dept. of Anesthesiology and Intensive Care, University of Lund, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38164585.html.

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11

Zygmunt, Peter. "Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle." Lund : Dept. of Clinical Pharmacology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/38253127.html.

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12

Haneef, Randa. "The Role of Human Cord Blood Endothelial Colony Forming Cell-Derived Extracellular Vesicles In Acute Kidney Injury (AKI)." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37627.

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Acute kidney injury (AKI) is a sudden reduction in renal function, associated with a high mortality rate. The main cause of AKI is ischemia reperfusion injury. We previously found that administration of endothelial colony forming cells (ECFCs) or their derived exosomes protects ischemic renal cells against ischemia via paracrine action. Moreover, ECFC-derived exosomes are highly enriched with miRNA-486-5p, which protects against ischemia. Unexpectedly, ECFC infusion into mice with AKI attenuates renal endothelial cell proliferation. Therefore, we examined the role of ECFC-derived exosomes and

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13

Graham, U. "Endothelial function, the renin-angiotensin-aldosterone axis (RAAS) and hypertension : diagnostic strategies and therapeutic role of potassium supplementation." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557606.

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There is limited evidence of the effect of potassium on endothelial function. Three studies suggest a beneficial effect. Potassium raises aldosterone which has a negative effect on cardiovascular health. We aimed to determine the effect of potassium on endothelial function and the renin-angiotensin-aldosterone system in patients with moderate cardiovascular disease risk. We investigated potential new diagnostic and therapeutic interventions in patients with primary hyperaldosteronism (P A). Lastly we reviewed the outcomes in patients with P A who underwent adrenal venous sampling (A VS). The f

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14

Bodelsson, Gunilla. "Endothelial and adrenergic vascular mechanisms in the female reproductive system." Malmö : Dept. of Obstetrics and Gynecology, University of Lund, Malmoe University Hospital, 1995. http://catalog.hathitrust.org/api/volumes/oclc/38161037.html.

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15

Paye, Julie Melissa Davis. "Effect of the Insulin-like Growth Factor (IGF) Axis on the Transport Properties of Endothelial and Epithelial Cells In Vitro." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/29071.

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The overall objective of this research consists of two main parts: (1) provide evidence that autocrine production of IGF-I modulates tight junction permeability and (2) demonstrate the ability of IGFBPs to regulate IGF-I delivery across cell layers. To meet the first objective, parental and IGF-I secreting bovine mammary epithelial cells were tested for cell layer permeability, tight and adherens junction proteins, IGF-IR, and a downstream signaling components of IGF-IR. In comparison with parental cells, IGF-I secreting cells had high levels of IGF-IRs, but low levels of the junction compon

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16

Ali, Sakina. "Rôle des vésicules extracellulaires dans la pathogenèse de la résistance à l’insuline dans le syndrome métabolique LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4." Thesis, Angers, 2020. http://bu.univ-angers.fr/Contact.

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Le syndrome métabolique (SMet) est un ensemble de troubles métaboliques associés à une dysfonction endothéliale et à une résistance à l’insuline. Grâce à leur cargaison qu’ils peuvent transférer d’une cellule à l’autre, les vésicules extracellulaires (VEs), incluant les grandes (lEVs) et les petites (sEVs) vésicules sont impliquées dans différentes voies de communication intercellulaire. Parmi toutes les recherches menées sur les VEs, l’étude de leur implication dans la physiopathologie des maladies métaboliques a mis en évidence de nombreuses communications intercellulaires délétères pour le

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17

Slebe, Concha Juan Felipe 1981. "The FoxA1/FoxA2-LIPG axis regulates beast cancer growth through changes in lipid metabolism." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299798.

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The Fox transcription factor family comprises FoxA1, FoxA2 and FoxA3, which regulate tissue development and metabolism. In breast cancer, FoxA1 together with estrogen receptor regulates tumor growth and luminal specification. However, it is still unclear whether other members of the FoxA family participate in breast cancer pathogenesis and whether they contribute to tumor metabolic dependence. Here we show that FoxA1 and FoxA2 expression is mutually exclusive across different human breast cancer cell lines. Although both transcription factors regulate different set of genes and biological resp

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18

Karlsson, Caroline. "Direct and endothelium-linked serotonergic control of vascular tone in human uterine and umbilical arteries." Lund : Dept. of Obstetrics and Gynaecology, University of Lund Malmö University Hospital, 1998. http://catalog.hathitrust.org/api/volumes/oclc/40420934.html.

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19

Karlsson, Håkan. "Influence of FK506 on certain aspects of lymphocyte activation and lymphocyte-endothelial cell interactions in vitro." Lund : Dept. of Medical Microbiology, Section of Clinical Immunology, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39799195.html.

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20

Camara, Abdouramane. "Control of lymphoid organ CD169+ macrophage differentiation by stromal cells through the RANK-RANKL axis." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ102.

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Au-delà de leurs rôles de sentinelles, de reconnaissance du danger et d’initiation des réponses protectrices, les signaux et le mécanisme qui gouvernent la formation des macrophages CD169 + sinusoïdaux ganglionnaires sont mal connus. Au cours de ma thèse, j’ai montré que la cytokine Receptor Activator of NF-kB Ligand (RANKL) est requise pour la formation de ces macrophages dès l’embryogenèse jusqu’aux quatre semaines après la naissance. Celle-ci est contrôlée par les cellules endothéliales lymphatiques (LECs) activées par RANKL produite par les cellules mésenchymateuses. Chez l’adulte, les LEC

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21

Chi, Chen Chia, and 陳佳琪. "Study on Endothelin Axis Involved in Macrophage-Induced Cancer Cells Metastasis." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/24446685129506317310.

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碩士<br>國防醫學院<br>生物及解剖學研究所<br>95<br>Adhesion of tumor cells onto vascular endothelial cells and subsequent transendothelial migration are essential steps for cancer cells to enter in or exit from the vessels and thus metastasize to different tissues/organs. Tumor-associated macrophages have been known to provide many aids on tumor metastasis and malignant progression. In this study, we provide evidence demonstrating that macrophage conditioned medium (MCM) was able to induce human breast cancer MCF-7 and nasopharyngeal carcinoma NPC-TW01 cells to migrate toward and furthermore adhere onto end

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22

"The angiotensin converting enzyme 2 - angiotensin (1-7) axis protects endothelial function against oxidative stress in diabetes." 2013. http://library.cuhk.edu.hk/record=b5884510.

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Zhang, Yang.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 147-169).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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23

Catar, Rusan Ali [Verfasser]. "Proatherosklerotische Wechselwirkung von oxidativem Stress, Low-density-Lipoprotein, Angiotensin II und Endothelin-1 in humanen Endothelzellen / von Rusan Ali Catar." 2007. http://d-nb.info/98584826X/34.

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24

Wang, Shur-Jen. "Study of yolk sac-derived endothelial cells." 1996. http://catalog.hathitrust.org/api/volumes/oclc/35676527.html.

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25

Yu, Duonan. "Mouse yolk sac endothelial cells and their organ-specific differentiation." 1998. http://catalog.hathitrust.org/api/volumes/oclc/42895468.html.

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26

Vann, James M. "Staphylococcus aureus ingested by cultured bovine endothelial cells express cytotoxic activity." 1986. http://catalog.hathitrust.org/api/volumes/oclc/15694313.html.

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27

Nör, Jacques Eduardo. "The role of endothelial cell survival and death signals in angiogenesis." 1999. http://catalog.hathitrust.org/api/volumes/oclc/68803397.html.

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28

Cale, Jacqueline M. "Regulation of endothelial nitric oxide synthase by intracellular calcium and phosphorylation." 2005. http://catalog.hathitrust.org/api/volumes/oclc/64130091.html.

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29

King, Adam Gideon. "Estrogen induces uterine angiogenesis through the expression of vascular endothelial growth factor." 2002. http://catalog.hathitrust.org/api/volumes/oclc/50860308.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 2002.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 118-135).

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30

Lam, Tim-Tak. "Interactions of angiotensin I with endothelial cells angiotensin-converting enzyme and angiotensin I binding /." 1985. http://catalog.hathitrust.org/api/volumes/oclc/12871496.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1985.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 171-191).

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31

Soden, Ryan Ivan. "Intracellular signaling in LTA-induced VEGF expression of dental pulp cells a dissertation submitted in partial fulfillment ... for the degree of Master of Science in Endodontics ... /." 2005. http://catalog.hathitrust.org/api/volumes/oclc/67878283.html.

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32

Gosink, Eric Christopher. "Calcium homeostasis and its role in the formation of vasoactive substances in porcine adrenal medulla endothelial cells." 1995. http://catalog.hathitrust.org/api/volumes/oclc/34406861.html.

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33

Koehler, Shannon M. "Pregnancy-specific changes in Ca²⁺ signaling in uterine artery endothelial cells derived from pregnant and nonpregnant ewes." 2005. http://catalog.hathitrust.org/api/volumes/oclc/70825440.html.

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34

Di, Tao. "The role of intracellular Ca2+ mobilization and extracellular signal-regulated kinases in mediating pregnancy-induced changes in the uterine artery endothelial vasodilator production." 2000. http://catalog.hathitrust.org/api/volumes/oclc/46590495.html.

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35

"The protective role of KLF2-UCP2 axis in restoration of endothelial function in type 2 diabetes: Kruppel樣因子2-解偶聯蛋白2信號軸保護二型糖尿病血管內皮功能的研究". 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291436.

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Luo, Jiangyun.<br>Thesis Ph.D. Chinese University of Hong Kong 2015.<br>Includes bibliographical references (leaves 97-117).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on 03, October, 2016).<br>Luo, Jiangyun.

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36

Ling, Ling. "Investigarion of Activated Phosphaidylinositol 3’ Kinase Signaling in Stem Cell Self-renewal and Tumorigenesis." Thesis, 2012. http://hdl.handle.net/1807/32815.

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The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival, and glucose transport, and is implicated in various disease states such as cancer and diabetes. Though there have been numerous studies dissecting the role of PI3K signaling in different cell types and disease models, the mechanism by which PI3K signaling regulates embryonic stem (ES) cell fate remains unclear. It is believed that in addition to proliferation and tumorigenicity, PI3K activity might also be important for self-renewal of ES cells. Paling et al. (200

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