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Relevant bibliographies by topics / Enediynes

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Academic literature on the topic 'Enediynes'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Enediynes"

1

Polukhtine, Andrei, Grigori Karpov, Dinesh R. Pandithavidana, Alexander Kuzmin, and Vladimir V. Popik. "Photochemical Triggering of the Bergman and Myers - Saito Cyclizations." Australian Journal of Chemistry 63, no. 7 (2010): 1099. http://dx.doi.org/10.1071/ch10185.

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Two strategies for the photochemical generation of reactive enediyne compounds and their subsequent cycloaromatization to p-benzyne or α,3-didehydrotoluene derivatives are discussed in this account. The first method employs a photo-Wolff reaction of stable 11- or 12-membered ring precursor enediynes containing the 2-diazo-1,3-diketone moiety. Irradiation of these compounds results in ring contraction and the formation of two isomeric enediynes possessing an enolized β-ketoester fragment. One of the isomers undergoes the conventional Bergman cyclization, whereas the other isomerizes into the en

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2

Balova, Irina, Natalia Danilkina, Andrey Rumyantsev, Anna Lyapunova, Alexander D’yachenko, and Alexander Khlebnikov. "10-Membered Azaenediyne Fused to a Benzothiophene through the Nicholas Macrocyclization: Synthesis and DNA Cleavage Ability." Synlett 30, no. 02 (2018): 161–66. http://dx.doi.org/10.1055/s-0037-1610352.

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The Nicholas-type macrocyclization through NH-tosyl functional group has been found to be an efficient technique for the synthesis of a 10-membered azaenediyne system annulated with a benzothiophene. To compare the activity of azaenediyne synthesized with similar oxa- and carbocyclic enediynes the Bergman cyclization activation energies and the ability of enediynes to cleave DNA (pBR322 plasmid) were investigated. The order of reactivity predicted by DFT calculations (N-enediyne < C-enediyne < O-enediyne) was confirmed by DSC analysis data. Surprisingly azaenediyne was found to be more a

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Diwan, S. Rawat. "Target directed enediynes Chemical and biological significance." Journal of Indian Chemical Society Vol. 85, Feb 2008 (2008): 130–41. https://doi.org/10.5281/zenodo.5808681.

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Department of Chemistry, University of Delhi, Delhi-110 007, India E-mail : dsrawat@chemistry.du.ac.in Manuscript received 26 November 2007, accepted 30 November 2007 The novel chemical framework and potent antitumor activity of the enediyne natural products such as calicheamicin, dynemicin, esperamicin, and neocarzinostatin has fostered interest in the development of simple enediynes with low thermal cyclization temperature. It is well established that thermally labial enediynes exhibit anticancer activity, while there are few scattered examples in the literature about the biological importan

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4

Klein, Michael, Thomas Walenzyk, and Burkhard König. "Electronic Effects on the Bergman Cyclisation of Enediynes. A Review." Collection of Czechoslovak Chemical Communications 69, no. 5 (2004): 945–65. http://dx.doi.org/10.1135/cccc20040945.

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The thermal cyclisation of enediynes to benzene-1,4-diyl diradicals (Bergman cyclisation) is affected by geometrical and electronic conditions. While the effect of ring strain or conformational constrains on the cyclisation temperature has been investigated in detail, electronic contributions have been less studied. Often geometrical and electronic contributions cannot be clearly distinguished. In most cases metal ion chelation does involve both. In this review we have summarised clear-cut observations of electronic substituents effects on the thermal enediyne reactivity. The effects of substi

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5

Adhikari, Ajeeth, Ben Shen, and Christoph Rader. "Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates." Antibody Therapeutics 4, no. 1 (2021): 1–15. http://dx.doi.org/10.1093/abt/tbab001.

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Abstract Calicheamicin, the payload of the antibody-drug-conjugates (ADCs) gemtuzumab ozogamicin (Mylotarg®) and inotuzumab ozogamicin (Besponsa®), belongs to the class of enediyne natural products. Since the isolation and structural determination of the neocarzinostatin chromophore in 1985, the enediynes have attracted considerable attention for their value as DNA damaging agents in cancer chemotherapy. Due to their non-discriminatory cytotoxicity towards both cancer and healthy cells, the clinical utilization of enediyne natural products relies on conjugation to an appropriate delivery syste

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Gredičak, Matija, and Ivanka Jerić. "Enediyne compounds - new promises in anticancer therapy." Acta Pharmaceutica 57, no. 2 (2007): 133–50. http://dx.doi.org/10.2478/v10007-007-0011-y.

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Enediyne compounds - new promises in anticancer therapyScientists of all kinds have long been intrigued by the nature, action and potential of natural toxins that possess exceptional antibacterial and anticancer activities. These compounds, named enediynes, are among the most effective chemotherapeutic agents known. Often compared with intelligent weapons, due to the unique structure and sophisticated mechanism by which they destroy double-helical DNA, enediyne antibiotics are nowadays the most promising leaders in the anticancer therapy. Apart from their diversity, enediyne compounds share so

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7

Amit, Basak, Moh'd Bdour Hussam, and C. Shain Jagadish. "Studies on Bergman cyclization, the chemistry at the heart of enediynes." Journal of Indian Chemical Society Vol. 76, Nov-Dec 1999 (1999): 679–88. https://doi.org/10.5281/zenodo.5862222.

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Department of Chemistry, Indian Institute of Technology, Kharagpur-721 302, India <em>Manuscript received 20 September 1999</em> The kinetics of Bergman cyclization (BC) which is dependent upon a number of steric and stereoelectronic parameters, have been studied in various nitrogen-substituted cyclic enediynes. The simplest of these, a 10-membered enediyne 33 cyclized spontaneously (<em>t</em><sub>1/2</sub> = 72 h at 23°) and caused significant cleavage of supercoiled double stranded DNA at micromolar level. The degree of pyramidalization of the ring nitrogen in these enediynes has a

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8

Danilkina, Natalia A., Ekaterina A. Khmelevskaya, Anna G. Lyapunova, et al. "Functionalized 10-Membered Aza- and Oxaenediynes through the Nicholas Reaction." Molecules 27, no. 18 (2022): 6071. http://dx.doi.org/10.3390/molecules27186071.

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The scope and limitations of the Nicholas-type cyclization for the synthesis of 10-membered benzothiophene-fused heterocyclic enediynes with different functionalities were investigated. Although the Nicholas cyclization through oxygen could be carried out in the presence of an ester group, the final oxaenediyne was unstable under storage. Among the N-type Nicholas reactions, cyclization via an arenesulfonamide functional group followed by mild Co-deprotection was found to be the most promising, yielding 10-membered azaendiynes in high overall yields. By contrast, the Nicholas cyclization throu

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9

Ichino, Rina, Atsuya Momotake, and Tatsuo Arai. "Photochemical properties of enediyne-cored dendrimers bearing naphthalenes at the periphery." Canadian Journal of Chemistry 97, no. 2 (2019): 112–19. http://dx.doi.org/10.1139/cjc-2018-0128.

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A novel series of trans and cis enediyne-cored dendrimers bearing naphthalenes at the periphery were synthesized and their photochemical properties were examined. The trans/cis isomer ratio in the photostationary state was dependent on the excitation site in the dendrimers. When the enediyne core was selectively excited, the trans/cis isomer ratio in the photostationary state was either around 50/50 or a cis-rich mixture in all dendrimers due to the larger molar extinction coefficient of the trans-enediynes. On the other hand, when naphthalene was excited, a trans-rich mixture was unexpectedly

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10

Grissom, Janet Wisniewski, Trevor L. Calkins, and Heidi A. McMillen. "Tandem enediyne-radical cyclization expansion to nonaromatic enediynes." Journal of Organic Chemistry 58, no. 24 (1993): 6556–58. http://dx.doi.org/10.1021/jo00076a010.

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Dissertations / Theses on the topic "Enediynes"

1

Tive, Emmanuel. "Synthetic Approaches to 1,2-bis (3,3,3-trifluoropropynyl) Benzene." Bowling Green State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1224544914.

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2

Lee, Linda I.-Lin. "Synthesis and reactivity of organometallic enediynes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3025940.

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PEROSA, Alvise. "The Iron Promoted Cyclocarbonylation of Enediynes." Doctoral thesis, country:USA, 1996. http://hdl.handle.net/10278/28393.

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Karpov, Grigori V. "Activation of Enediynes by Photochemical Ring Contraction: Design, Synthesis and Reactivity of Cyclic Enediynes Containing Diazodicarbonyl Moiety." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1134408707.

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5

Soscia, Marco Gennaro. "Studies towards the asymmetric synthesis of neocarzinostatin chromophore aglycon." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250515.

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6

David, Wendi Marjene. "Studies of a new class of aza-enediynes : aza-Bergman cyclization and the potential use of aza-enediynes as antitumor agents /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004248.

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7

Comanita, Bogdan Mihai. "Studies on the development of synthetic routes to enediynes." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/9635.

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The thesis investigates synthetic routes to enediynes, a class of compounds of widespread interest due to their unusual molecular structure, potent antitumor activity and interesting mode of action. The preparation of eleven and twelve membered ring enediynes bearing oxy substituents in both propargylic positions is described via a novel intramolecular samarium diiodide coupling reaction of $\alpha,\beta$-unsaturated acetylenic aldehydes.* Other synthetic strategies based on various cyclization reactions (crossed aldol condensation, acetylide electrophile reaction, silicon directed electrophil

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Comanita, Bogdan M. "Studies on the development of synthetic routes to enediynes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21959.pdf.

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Khan, Safraz. "Studies towards the synthesis of Neocarzinostatin chromophore and related analogues." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360530.

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Rodgers, Betsy L. "Photosensitive ferrocene-based enediynes and nucleophilic addition to a para-benzyne." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3237571.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed December 13, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Books on the topic "Enediynes"

1

1932-, Borders Donald B., and Doyle Terrence W. 1942-, eds. Enediyne antibiotics as antitumor agents. M. Dekker, 1995.

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2

Enediyne Antibiotics as Antitumor Agents. Informa Healthcare, 1994.

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3

Barr, Douglas MacPherson. Mechanistic probes to the enediyne anticancer antibiotics. 1999.

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4

Low, Eddy Wai-Mang. Reactions towards enediyne heterocycles and nitroimidazoles: Incorporating alkynes. Dept of Chemistry, U of Toronto, 1999.

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Book chapters on the topic "Enediynes"

1

Schor, Nina Felice. "The Enediynes." In Cancer Therapeutics. Humana Press, 1997. http://dx.doi.org/10.1007/978-1-59259-717-8_11.

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2

Granger, Abra, Travis Greene, and Carol A. Parish. "Bergman Cyclization of Maleimide-Based Enediynes." In ACS Symposium Series. American Chemical Society, 2022. http://dx.doi.org/10.1021/bk-2022-1428.ch010.

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3

Goldberg, I. H., L. S. Kappen, Y. J. Xu, et al. "Enediynes as Probes of Nucleic Acid Structure." In DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0251-0_1.

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4

Ito, Yukishige, and Shino Manabe. "Synthesis of Enediyne Antibiotic Oligosaccharides." In Glycoscience: Chemistry and Chemical Biology I–III. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56874-9_59.

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5

Sugiura, Yukio, and Tetsuya Kusakabe. "Dynemicin A, A Novel Enediyne DNA Cutter." In DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0251-0_5.

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6

de Oteyza, Dimas G. "Enediyne Cyclization Chemistry on Surfaces Under Ultra-High Vacuum." In Advances in Atom and Single Molecule Machines. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26600-8_4.

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7

Hirama, Masahiro. "Synthesis and Chemistry of Nine-Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics." In Neocarzinostatin. Springer Japan, 1997. http://dx.doi.org/10.1007/978-4-431-66914-2_4.

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8

Bhattacharyya, Sibaprasad, Sangita, and Jeffrey M. Zaleski. "Unique Metal-Diyne, -Enyne, and -Enediyne Complexes: Part of the Remarkably Diverse World of Metal-Alkyne Chemistry." In Progress in Inorganic Chemistry. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470144428.ch6.

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9

Skrydstrup, Troels, Gerardo Ulibarri, Hélène Audrain, and David S. Grierson. "The “Enediyne” Antibiotics Calicheamicin γ 1 I , Esperamicin-A1, and Dynemicin-A: Physicochemical and Biological Properties-Partial and Total Synthesis." In Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products Vol. 2. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78250-3_6.

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"Enediynes." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_5344.

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Conference papers on the topic "Enediynes"

1

Balova, I., N. A. Danilkina, and A. I. Govdi. "DESIGN AND SYNTHESIS OF HETEROCYCLIC ANALOGS OF ENEDIYNE ANTIBIOTICS." In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-55.

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2

Ernesto, B., F. Behzad, P. Charles, S. Dennis, and T. Hossein. "Processable Enediyne Resins and the High Yielding Glassy Carbons Derived Therefrom." In SAMPE neXus 2021. NA SAMPE, 2021. http://dx.doi.org/10.33599/nasampe/s.21.0618.

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3

Xiaofang, Guo, Xiaofei Zhu, Yue Shang, Shenghua Zhang, Yongsu Zhen, and Wancai Yang. "Abstract 5478: A bispecific enediyne-energized fusion protein Ec-LDP-Hr-AE enhances anti-cancer efficacy on esophageal cancer cells by targeting EGFR and HER2." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5478.

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Reports on the topic "Enediynes"

1

Tour, James M., and Jens A. John. Synthesis of Polyphenylenes via Bergman Cyclization of Enediyne Monomers. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada273298.

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