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Dissertations / Theses on the topic 'Enediynes'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Tive, Emmanuel. "Synthetic Approaches to 1,2-bis (3,3,3-trifluoropropynyl) Benzene." Bowling Green State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1224544914.

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2

Lee, Linda I.-Lin. "Synthesis and reactivity of organometallic enediynes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3025940.

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3

PEROSA, Alvise. "The Iron Promoted Cyclocarbonylation of Enediynes." Doctoral thesis, country:USA, 1996. http://hdl.handle.net/10278/28393.

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4

Karpov, Grigori V. "Activation of Enediynes by Photochemical Ring Contraction: Design, Synthesis and Reactivity of Cyclic Enediynes Containing Diazodicarbonyl Moiety." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1134408707.

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5

Soscia, Marco Gennaro. "Studies towards the asymmetric synthesis of neocarzinostatin chromophore aglycon." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250515.

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6

David, Wendi Marjene. "Studies of a new class of aza-enediynes : aza-Bergman cyclization and the potential use of aza-enediynes as antitumor agents /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004248.

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7

Comanita, Bogdan Mihai. "Studies on the development of synthetic routes to enediynes." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/9635.

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The thesis investigates synthetic routes to enediynes, a class of compounds of widespread interest due to their unusual molecular structure, potent antitumor activity and interesting mode of action. The preparation of eleven and twelve membered ring enediynes bearing oxy substituents in both propargylic positions is described via a novel intramolecular samarium diiodide coupling reaction of $\alpha,\beta$-unsaturated acetylenic aldehydes.* Other synthetic strategies based on various cyclization reactions (crossed aldol condensation, acetylide electrophile reaction, silicon directed electrophil

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8

Comanita, Bogdan M. "Studies on the development of synthetic routes to enediynes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21959.pdf.

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9

Khan, Safraz. "Studies towards the synthesis of Neocarzinostatin chromophore and related analogues." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360530.

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10

Rodgers, Betsy L. "Photosensitive ferrocene-based enediynes and nucleophilic addition to a para-benzyne." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3237571.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed December 13, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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11

Leach, Debbie M. "A reactivity study of the palladium cross-coupling synthesis of enediynes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/MQ52063.pdf.

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12

Friese, Seth J. "Metal-mediated cycloaromarization of enediynes and dienynes : scope and mechanistic investigations /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3148252.

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13

Blanchette, Heather Smith. "Part 1--Studies on an approach to the total synthesis of (+)-pancratistatin via an episulfonium cation ; Part 2--Synthetic, structural and thermal studies of bisenediyne macrocycles /." view abstract or download file of text, 1999. http://wwwlib.umi.com/cr/uoregon/fullcit?p9955913.

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Thesis (Ph. D.)--University of Oregon, 1999.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 162-172). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p9955913.

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14

Barr, Douglas MacPherson. "Mechanistic probes to the enediyne anticancer antibiotics." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401478.

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The work described in this thesis details the design, synthesis and evaluation of molecules intended as mechanistic probes to the enediyne anticancer antibiotics. In particular it examines the role of radical and ionic accepting groups in analogue systems related to the DNA cleaving agent Neocarzinostatin chromophore (NCS). The application of novel methodologies towards the synthesis of a number of key precursors and model systems is discussed. Initial studies concentrated on the versatile synthesis of a model system bearing dienediyne and styryl motifs, from 2-cyclopentenone. The role of cycl

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15

Obali, Derya. "Synthetic Approaches To Fluorinated Ten-Membered Enediyne." Bowling Green State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1275448174.

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16

Harwig, Curtis W. "The taxamycins, a new family of enediyne compounds." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21970.pdf.

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17

Low, Eddy Wai Mang. "Reactions towards enediyne heterocycles and nitroimidazoles incorporating alkynes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0003/NQ41217.pdf.

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18

Geny, Anaïs. "Cycloadditions [2+2+2] catalysées par des complexes du cobalt : utilisation de nouveaux partenaires et développement de nouveaux systèmes catalytiques." Paris 6, 2008. http://www.theses.fr/2008PA066448.

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Cette thèse porte sur les cycloadditions [2+2+2] catalysées par les complexes du cobalt. La première partie de ce manuscrit traite de la cocyclisation d’esters alcynylboroniques avec des alcènes. Nous avons obtenu différents cyclohexadiènes diborés qui ont pu être fonctionnalisés par couplage de Suzuki. Le développement de nouveaux systèmes catalytiques fait ensuite l’objet d’une seconde partie. Un système à base de diiodure de cobalt, de manganèse et d’un carbène N-hétérocyclique s’est révélé être très efficace pour la cyclisation d’ènediynes. Enfin la réactivité d’un nouveau complexe du coba

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19

Gormley, Julie A. "Investigation of the use of enediyne apoproteins as scaffolds for directed evolution." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416426.

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20

Cooke, Heather A. "Studies of Key Enzymes Involved in the Biosynthesis of the Enediyne Antitumor Antibiotics Neocarzinostatin and C-1027." Thesis, Boston College, 2009. http://hdl.handle.net/2345/1344.

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Thesis advisor: Steven D. Bruner<br>The enediyne antitumor antibiotics are produced by complex biosynthetic machinery in acetomycetes. This dissertation will focus on the study of three enzymes involved in key steps in the biosynthesis of two enediynes, neocarzinostatin and C-1027. Neocarzinostatin is biosynthesized by a number of enzymes that synthesize and decorate the enediyne core and the peripheral moieties. NcsB1 is one enzyme involved in functionalizing the naphthoic acid portion of neocarzinostatin, a key group involved in binding to target DNA duplexes. The enzyme has been shown to be

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21

Parbin, Elbin Sehnza. "Synthesis of polycyclic aromatic hydrocarbons via benzannulated enediynyl alcohols." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5331.

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Thesis (M.S.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains vii, 65 p. : ill. Includes abstract. Includes bibliographical references (p. 33-36).

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22

Christenson, Steven Dale. "Genetic and biochemical characterization of C-1027 enediyne biosynthesis cluster from Streptomyces globisporus /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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23

Xu, Jinghai 1969. "The selection of DNA damage targets in vivo and in vitro by enediyne antitumor antibiotics." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50416.

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24

ALLAMEL, RACHEL HEIDE. "Mecanisme d'action moleculaire d'anticancereux du type enediyne : contribution a la synthese d'analogues de la neocarzinostatine." Strasbourg 1, 1994. http://www.theses.fr/1994STR15005.

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25

CHEVALIER, ROGER CECILE. "Conception et progres realises vers la synthese d'analogues antitumoraux de type enediyne inspires de la maduropeptine." Paris 11, 1999. http://www.theses.fr/1999PA112362.

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Au cours de cette these, nous avons entrepris l'elaboration de molecules de type enediyne. Pour ce faire, nous nous sommes inspires de la structure et du mecanisme d'action de l'artefact maduropeptine, et de la partie chromophore de la neocarzinostatine, toutes deux possedant de grandes proprietes antitumorales. Notre molecule cible a ete concue par une approche modulaire. Celle-ci peut etre scindee en quatre parties : une partie bioactive centrale contenant deux fonctions acetylenes et un motif dihydrooxazine, un noyau pyrrole, une connexion (chaine a 1 ou 2 atomes de carbone) et un element d

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26

Reyes-Rodriguez, Gabriel J. "Nucleophilic additions to a para-benzyne derived from an enediyne| Exploring the non-radical reactivity of a diradical." Thesis, University of California, San Diego, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3605959.

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<p> A new reaction of <i>para</i>-benzyne diradicals with anionic nucleophiles is different from their usual homolytic atom abstraction. Our studies show cyclodeca-1,5-diyn-3-ene undergoing rate-limiting cycloaromatization to a <i>para</i>-benzyne, which rapidly adds nucleophiles to produce an aryl anion, which is then quenched by solvent or water to form 1-(Nu)tetrahydronaphthalenes. Our results represent the first example of anionic nucleophiles, other than halides, reacting towards a <i>para</i>-aryne. Our reactivity scale reflects the ease of Nu<sup>−</sup> desolvation, with the smal

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27

Kiappes, John Leon. "Synthesis and biological characterization of natural and designed sugars." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:ccc0e4dd-a8b4-445b-9fee-260c35b0040d.

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Carbohydrates represent a keystone among biological molecules. Well known as a source of energy, sugars also form the backbone of various biopolymers, act as markers and receptors for cellular communication and modulate lipid and protein functions. As such a powerful class, carbohydrates represent a useful pool from which both nature and man have drawn structures to produce biologically active compounds with a variety of modes of action. Beyond their importance to biology, sugars have represented attractive synthetic targets to chemists given their densely functionalized scaffolds. The work pr

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28

Tuntiwechapikul, Wirote. "Studies of a G-quadruplex-specific cleaving reagent, expansion of long repetitive DNA sequences, and a cytosine-specific alkylating aza-enediyne /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3055255.

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29

Sriram, Madhavi Pinney Kevin G. "Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer." Waco, Tex. : Baylor University, 2007. http://hdl.handle.net/2104/5121.

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30

Borie, Cyril. "Activité anticancéreuse et réactivité des ènediynes." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4737.

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La synthèse d’une nouvelle famille d’ènediynes comportant un motif perfluoré a été réalisée en 6 à 7 étapes. Leur activité anticancéreuse a été étudiée sur un panel de lignées cellulaires provenant de différents tissus ; des IC50 de l’ordre du µM ont été obtenus. Leur réponse en IRM du fluor 19 a aussi été évaluée, dans le but d’impliquer ces composés en théranostique (association de la thérapie et du diagnostic). Une étude mécanistique a été menée afin de comprendre le mécanisme biologique en jeu au cœur des cellules.Les ènediynes ont souvent vu leur développement stoppé en raison d’effets se

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31

Borie, Cyril. "Activité anticancéreuse et réactivité des ènediynes." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4737.

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La synthèse d’une nouvelle famille d’ènediynes comportant un motif perfluoré a été réalisée en 6 à 7 étapes. Leur activité anticancéreuse a été étudiée sur un panel de lignées cellulaires provenant de différents tissus ; des IC50 de l’ordre du µM ont été obtenus. Leur réponse en IRM du fluor 19 a aussi été évaluée, dans le but d’impliquer ces composés en théranostique (association de la thérapie et du diagnostic). Une étude mécanistique a été menée afin de comprendre le mécanisme biologique en jeu au cœur des cellules.Les ènediynes ont souvent vu leur développement stoppé en raison d’effets se

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32

Campolo, Damien. "Transfert de chiralité dans les réarrangements en cascade d'ènediynes." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4339/document.

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La synthèse asymétrique d’aza-hétérocycles (tétrahydro-isoquinoléines et naphtodiazépines) a été réalisée grâce à la mise en œuvre d’un processus faisant intervenir des réactions radicalaires et polaires en cascade à partir des ènediynes portant un centre stéréogène. Ce processus implique successivement : la formation d’un ényne-allène (via une migration-1,3 de proton, une réaction d’un alcyne terminal avec un carbénoïde de cuivre, ou encore une réaction d’homologation de Crabbé)/ la cyclisation de Saito-Myers/ le transfert-1,5 d’un atome d’hydrogène/ la recombinaison du biradical résultant. L

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Campolo, Damien. "Transfert de chiralité dans les réarrangements en cascade d'ènediynes." Electronic Thesis or Diss., Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4339.

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La synthèse asymétrique d’aza-hétérocycles (tétrahydro-isoquinoléines et naphtodiazépines) a été réalisée grâce à la mise en œuvre d’un processus faisant intervenir des réactions radicalaires et polaires en cascade à partir des ènediynes portant un centre stéréogène. Ce processus implique successivement : la formation d’un ényne-allène (via une migration-1,3 de proton, une réaction d’un alcyne terminal avec un carbénoïde de cuivre, ou encore une réaction d’homologation de Crabbé)/ la cyclisation de Saito-Myers/ le transfert-1,5 d’un atome d’hydrogène/ la recombinaison du biradical résultant. L

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34

冉穎芬. "Ruthenium and platinumcatalyzed aromatization of Enediynes." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/48919403102742702408.

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35

Chen, Yu-Chieh, and 陳俞絜. "Electronic Effects on the Cyclization of Enediynes." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/jqgeqr.

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碩士<br>國立中山大學<br>化學系研究所<br>106<br>Recently a series of transition-metal-catalyzed or halomediated cyclizations of enediynes and aryldiynes to give benzofulvenes, dibenzo[b,d]pyran-6-ones, benzo[a]carbazoles, ,benzo[b]naphtho[2,1-d]thiophenes and indeno[1,2-c]chromene have been reported. On the basis of the experimental results, we are able to understand more clearly the electron effect upon the mode of cyclization of these diyne derivatives. In this report, treatment of N-((2-((2-(dimethylamino)phenyl)ethynyl)phenyl) ethynyl)-N-methylmethanesulfonamide (1) with 10 mol% of palladium catalysts an

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LIN, CHI-FON, and 林志峰. "Cycloaromatization and cytotoxicity of enediynes and related molecules." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/29714255099681840523.

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博士<br>高雄醫學院<br>藥學研究所<br>87<br>英文摘要 In this dissertation, we divide it into two parts; one is the studies on the the cycloaromatization of eneduynes to form biradicals and their DNA cleavage activity and the other is the anionic cycloaromatization of enediynes. In the first of this dissertation, we have synthesized a series of eneduynes containing bispropargyl sulfone moiety 55a, 55b and 55c. The benzene solution of 55b, in the presence of triethylamine and 1,4-cyclohexadiene, was stirred at room temperature for 24hr to give aldehyde 69. The activity against the inhibition

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37

Breiner, Boris. "Enediynes C1 - C5 cyclization and application to DNA photocleavage /." 2006. http://etd.lib.fsu.edu/theses/available/etd-11132006-133123.

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Thesis (Ph. D.)--Florida State University, 2006.<br>Advisor: Igor V. Alabugin, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed May 7, 2007). Document formatted into pages; contains xix, 107 pages. Includes bibliographical references.

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38

Huang, Hsuan-Jung, and 黃萱榕. "Design and Synthesis of Enediynes Containing Propargyl Sulfone as Antitumor Agents." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/39191405645769133817.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學系碩士班<br>92<br>In this thesis, we designed and synthesized two types of anti-cancer compounds. One is the bissulfonyl endiyne compounds 74a~c; and the other is the enediyne sulfone containing propargylic sulfone moiety compounds 62a~d. Compounds 74a~c were prepared from propargyl alcohol, 1,2-diiodobenzene and diyne, and compounds 62a~d were synthesized from propargyl alcohol, 1,2-diiodobenzene and ynols. Most of the molecules show good growth inhibition properties against of tumor cell lines. Where as the IC50 value of compounds 74a~d and 62a~d ranged from 4.29 to 20μg/

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Zeidan, Tarek A. Alabugin Igor V. "Thermal and photochemical reactions of acetylenes I-ortho-effect in the Bergman cyclization of benzannelated enediynes ; II-photocycloaddition of diaryl acetylenes to cyclic dienes mechanisms and applications /." Diss., 2005. http://etd.lib.fsu.edu/theses/available/etd-09302005-153610.

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Thesis (Ph. D.)--Florida State University, 2005.<br>Advisor: Igor V. Alabugin, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Jan. 25, 2006). Document formatted into pages; contains xvi, 346 pages. Includes bibliographical references.

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40

Wang, Chun-Chieh, and 王俊傑. "Design and Synthesis of Enediynes Sulfone Containing Indole Carboxamide as Antitumor Agents." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/73593487511748496119.

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碩士<br>高雄醫學大學<br>藥學研究所碩士班<br>93<br>In this thesis, we designed and synthesized a new type conjugated anti-cancer compounds. Compounds 107a~c contain enediyne sulfone with indole carboxamide moiety. Compounds 107a~c were synthesized by palladium-catalyzed coupling reaction of aryl iodide 101 with alkynes 105a~c, followed by oxidation of the sulfide with mCPBA. The biologic activity of compounds 107a~c were examined for the growth inhibition activity against four human tumor cell lines. Among them, Compound 107a was found to have the highest potency against these tumor cell lines.

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Lo, Yu-Hsiang, and 羅宇翔. "Design and Synthesis of Novel Enediynes and Their Derivatives as Antimitosis Agents." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/26238457985717201947.

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博士<br>高雄醫學大學<br>藥學研究所<br>97<br>This dissertation is composed of three parts; first, we designed a new series of enediyne and their derivatives and evaluated for their growth inhibition activity against human tumor cell lines. We have found a lot of compounds that displayed potent growth inhibition of cancer cell, such as compound 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline (37c). According to the mechanism assay, these compounds, displayed a significant G2/M phase arrest via microtubules depolymerization and induced apoptotic progress. Second, we coupled 2-(6-(2-trifluoromethy

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42

Tseng, Kuo-Feng, and 曾國峰. "Synthesis and Biological Evaluation of Novel Symmetry Bis-enediynes and Their Derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/39570398526011029094.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士班<br>94<br>In this thesis, a series of novel symmetry bis-enediyne and their derivatives have been synthesized successfully and their bioactivity were evaluated. Among them, 1,6-Bis(4-((2-(pyridin-2-ylethynyl)phenyl) ethynyl)phenoxy)hexane (59) showed good inhibition activity against the KB cells, Hela cells, Daoy cells and WiDr cells. The cell-cycle analysis shows that compound 59 inhibits two enzymes, cyclin A and cyclin B, and induces a significant blockage in G2/M phase by Flow Cytometric Analsis and Western plotting. An apoptotic poptotic progress induction was

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Lu, Wen-Te, and 盧文德. "Nucleophile, Electrophile and Transition Metals Promoted Cyclization of Enediynes and Related Moleculars." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/29144063972123193838.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>94<br>In this dissertation, we focus on the cyclization reactions of enediynes. In the first part of this dissertation, we extended the anionic cycloaromatization of enediyne to the synthesis of the benzo[b]naphtha[1,2-a]furans. It was found that treatment of 2-[(3Z, 7Z)-hexadeca-3,7-diene-1,5,9-triynyl]phenyl tert-butyldimethyl ether with K2CO3 in N, N-dimethyl formaldehyde (DMF) containing two equivalents of methanol refluxing temperature gave 10-hexylbenzo[b]naphtha[1,2-a]furan in 33% yield. On the other hand, reaction of 2-alkynylbenzonitriles with aryl iodides

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44

Wu, Man-Yun, and 吳曼筠. "Copper bromide-catalyzed cyclization reaction of enediynes to11-bromoindeno[1,2-c]chromenes." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/41130295741037611986.

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碩士<br>國立中山大學<br>化學系研究所<br>104<br>Treatment of anisole-substituted aryldiyne with 2 equiv of copper bromide (II) in 120 oC acetonitrile gave 11-bromo-6-phenylindeno[1,2-c]chromene in good yields . This method tolerated various functional groups in phenyl moiety, and some electron donating group can provide dimer results.

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45

Peabody, Scott W. Alabugin Igor V. "Tributyltin mediated radical cyclizations of enediynes and their subsequent transformation to fulvenes and indenes." 2004. http://etd.lib.fsu.edu/theses/available/etd-04302004-115336.

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Thesis (M.S.)--Florida State University, 2004.<br>Advisor: Dr. Igor Alabugin, Florida State University, College of Arts and Science, Dept. of Chemistry and Biochemistry. Title and description from dissertation home page (viewed Sept. 23, 2004). Includes bibliographical references.

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Tsai, Chih-Wei, and 蔡志威. "Studies on the Cyclization Reactions of Enediynes and Related Molecules with Sodium Azide." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/42742998564144765547.

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博士<br>高雄醫學大學<br>藥學研究所<br>99<br>In this dissertation, three different reactions of enediynes and related molecules with sodium azide are presented. In the first part, the reactions of (Z)-1,6-disubsituted-3-hexen-1,5-diynes with sodium azide in DMSO at 80 oC to give 1,2,3-triazolo[1,5-a]pyridine are described. Various symmetrical or unsymmetrical enediynes were carried out in this study and led to the products formation in modest to good yields. In the second part, the selective syntheses of 4,5-disubstituted-2H-1,2,3-triazoles and tetrazolo[5,1-a]isoquinolines by the reactions of 2-alkynylbezo

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Chen, Chiu-Mei, and 陳秋美. "Transition Metal-catalyzed cyclization reaction of enediynes to benzo[b]naphtho[2,1-d]thiophene." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/16526541842404153414.

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碩士<br>國立中山大學<br>化學系研究所<br>100<br>Treatment of thioanisole-substituted aryldiyne with 2 equiv. of N-Iodosuccinimide and 5 mol% of PPh3AuCl and 5 mol% AgSbF6 in refluxing dichloromethane gave 5-iodo benzo[b]naphtho[2,1-d]thiophene in good yields. This method tolerated various functional groups in alkyl and phenyl moiety. We also treatment thioanisole-substituted aryldiyne with 10 mo% of PdX2 and 3 equiv. CuX2 (X= Cl, Br),in reluxing THF gave in 5-position have halogen substitute benzo[b]naphtho[2,1-d]thiophene derivative.

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Lee, Chia-Ying, and 李佳螢. "Synthesis of Heteorcycles and Aromatic Compounds via Nucleophilic-Promoted and Palladium-Catalyzed Cycloaromatization of Enediynes." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/43982463434653262719.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>94<br>Recently, synthesis of several aromatic compounds, including isoquinolones, phenanthridinones, and biphenyls have been achieved by anionic cycloaromatization of enediynes in our lab. As part of our on going researches, these applications were applied to the preparation of two series of bioactive compounds, dibenzofurans and carbazoles, from various enediyne precursors. First of all, reaction of 2-(6-substituted 3(Z)-hexen-1,5-diynyl)phenyl tert-butyldimethyl ethers with sodium methoxide at reflux in methanol gave dibenzofurans in good yields. On the other hand

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Chen, Yi-Han, and 陳逸涵. "Study on the Cyclization Reaction of Enediynes to Naphthalene Derivatives, and Optoelectronic of Naphthalene Compounds." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/c4a72k.

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碩士<br>國立中山大學<br>化學系研究所<br>106<br>This dissertation describes a new synthetic method of naphthalene derivatives by using palladium-catalyzed cyclization of enediyne compounds . Meanwhile, we discussed the optimization conditions for this cyclization reaction. Furthermore, we synthesized a series of naphthalene derivatives bearing different substituents . After reducing naphthalene derivatives to amine and reacting it with a hypervalent iodine reagent, a naphthalene compounds with benzisoxazole skeletons was obtained. We studied the physical properties of these materials. The experimented result

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Tuesuwan, Bodin 1975. "DNA cleavage chemistry of pyridinium-based heterocyclic skipped aza-enediynes and targeting SV40 large T-antigen G-quadruplex DNA helicase activity by G-quadruplex interactive agents." Thesis, 2007. http://hdl.handle.net/2152/3711.

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Two diverse works regarding DNA-Drug Interaction are presented here. The first portion deals with covalent interactions between compounds that are derivatives of heterocyclic aza-enediynes and DNA (conventional Watson-Crick base paired double stranded DNA) and the second is related to non-covalent interactions of these compounds with G-quadruplex DNA. The aza-enediynes have been studied for their ability to undergo aza-variants of the Bergman and Myers cyclizations, and the potential role of the ensuing diradicals in DNA cleavage chemistry. The aza-Myers-Saito cyclization of aza-enyne allene

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