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Journal articles on the topic 'Engagement conjugal'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Provost, Marc A., and Serge Tremblay. "Le nouveau-né et le couple : adversaires ou partenaires?" Santé mentale au Québec 16, no. 1 (2007): 235–50. http://dx.doi.org/10.7202/032212ar.

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RÉSUMÉ Nous acceptons généralement l'idée que la venue planifiée d'un premier enfant est source de joie pour les nouveaux parents et qu'elle fait naître aussi chez eux un sentiment d'accomplissement. Traditionnellement, la société considère d'un bon oeil le passage à ce nouveau rôle que constitue la formation d'une cellule familiale. Or, non seulement la recherche sur les relations conjugales a-t-elle mis de côté le romantisme de l'imagerie populaire, mais elle a petit à petit développé une idée négative de cette crise de transition. L'objectif de cet article est donc de faire d'abord une rece

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2

Meyer, Richard. "Mapping Type IV Secretion Signals on the Primase Encoded by the Broad-Host-Range Plasmid R1162 (RSF1010)." Journal of Bacteriology 197, no. 20 (2015): 3245–54. http://dx.doi.org/10.1128/jb.00443-15.

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ABSTRACTThe plasmid R1162 (RSF1010) encodes a primase essential for its replication. This primase makes up the C-terminal part of MobA, a multifunctional protein with the relaxase as a separate N-terminal domain. The primase is also translated separately as the protein RepB′. Here, we map two signals for type IV secretion onto the recently solved structure of RepB′. One signal is located internally within RepB′ and consists of a long α-helix and an adjacent disordered region rich in arginines. The second signal is made up of the same α-helix and a second, arginine-rich region at the C-terminal

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3

Bungardean1, Adriana, and Jo-Anne Wemmers. "Les femmes victimes de violence conjugale à la marge du système pénal : l’engagement 810 du Code criminel." Criminologie 50, no. 2 (2017): 189–201. http://dx.doi.org/10.7202/1041704ar.

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L’engagement 810 du Code criminel est une mesure couramment utilisée comme aboutissement du processus judiciaire dans les cas de violence conjugale. Au cours des dernières années, nous avons observé une augmentation du nombre d’engagements émis dans ces cas. À la fois mesure judiciaire et extrajudiciaire, le « 810 » est une mesure préventive et non punitive, ainsi elle n’occasionne pas de casier judiciaire pour le défendeur. Malgré son utilisation fréquente, peu d’études se sont penchées à savoir si l’engagement 810 est une mesure appréciée par les victimes et si on a répondu à leur besoin de

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4

Rigo, Rosa Maria, José António Marques Moreira, and Sara Dias-Trindade. "Avaliação e engagement acadêmico na Educação Superior: anseios e expectativas de estudantes do primeiro ano da graduação." Revista Meta: Avaliação 12, no. 37 (2020): 893. http://dx.doi.org/10.22347/2175-2753v12i37.2795.

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Promover o engagement no Ensino Superior, sobretudo, dos estudantes ingressantes, é um dos maiores desafios para professores e instituições educativas, conforme têm destacado vários estudos internacionais (KRAUSE, 2005; COATES, 2006). O presente artigo tem, pois, por objetivo analisar os fatores que mais contribuem para a promoção de engagement acadêmico no Ensino Superior, sendo um estudo que conjuga metodologicamente dois tipos de investigação: a qualitativa e a quantitativa. Os resultados revelam que os estudantes consideram que os fatores que mais promovem o engagement acadêmico são: Relaç

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5

Krajczyński, Jan. "Małżeństwo z muzułmaninem." Prawo Kanoniczne 52, no. 1-2 (2009): 175–200. http://dx.doi.org/10.21697/pk.2009.52.1-2.07.

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Il est vrai que la célébration du mariage canonique avec un musulman n’est pas un phénomène nouveau dans la pratique ecclésiale. Néanmoins, une affluence des adeptes de l’Islam dans des milieux jusqu’à présent en principe chrétiens, est l’effet de l’intensité de certains phénomènes sociaux et ne peut ne pas avoir d’influence sur la fréquence de ces célébrations. Cette affluence permanente des musulmans est liée, entre autres, aux phénomènes sociaux suivants: l’ouverture des frontières séparants les Etats, l’émigration en masse des travailleurs à la recherche d’asile, la diversité des formes de

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6

Lu, Jie, Zhiqin Cai, Bin Yao, and Binqiang Chen. "A novel engagement-pixel image edge tracking method for extracting gear tooth profile edge." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 234, no. 2 (2019): 405–16. http://dx.doi.org/10.1177/0954406219878738.

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Accurate gear profile plays an important role in determining the transmission performance of gear-drive equipment. In this paper, a novel method for extracting gear tooth profile edge is presented. The presented method is based on engagement-pixel image edge tracking (EPIET) technique, and does not rely on the traditional meshing theory. An algorithm for the proposed method is put forward. Firstly, instantaneous contact images between the envelope curves of the gear profile and the instantaneous locus of the cutting tool are acquired. Secondly, pixels on the boundary of the envelope curves are

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7

Meiring, James E., Rodrick Sambakunsi, Elvis Moyo, et al. "Community Engagement Before Initiation of Typhoid Conjugate Vaccine Trial in Schools in Two Urban Townships in Blantyre, Malawi: Experience and Lessons." Clinical Infectious Diseases 68, Supplement_2 (2019): S146—S153. http://dx.doi.org/10.1093/cid/ciy1110.

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Abstract Background To determine the efficacy of a new typhoid conjugate vaccine in an endemic setting in sub-Saharan Africa, the Typhoid Vaccine Acceleration Consortium is conducting a phase-3 randomized controlled trial in Blantyre, Malawi. This article describes community and stakeholder engagement activities before and during the trial, challenges, and lessons learned. Methods In October 2017, Malawi-Liverpool Wellcome Trust (MLW) organized a wide range of community engagement activities, including meetings with Ministry of Health and Education officials at the district and facility level,

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8

Soble, Adam, Zeenat Patel, Stephen Sosler, Lee Hampton, and Hope Johnson. "Gavi Support for Typhoid Conjugate Vaccines: Moving From Global Investments to Country Introduction." Clinical Infectious Diseases 71, Supplement_2 (2020): S160—S164. http://dx.doi.org/10.1093/cid/ciaa342.

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Abstract Nine years elapsed between Gavi’s investment decision to support typhoid conjugate vaccines (TCVs) in 2008 and Gavi support becoming available for countries to introduce TCV. The protracted path toward Gavi support for TCV highlights the challenges of vaccine development for lower-income countries and the importance of Gavi engagement as early as possible in product development processes to support the alignment of manufacturing, global policy, and program implementation. Early engagement would provide inputs to inform strategic vaccine investment decisions that transition more effici

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9

Liu, Hu Ran. "The Analytical Method of the Construction of the Profile of the Basic Rack for Equal Conjugate Curvature." Applied Mechanics and Materials 44-47 (December 2010): 2897–901. http://dx.doi.org/10.4028/www.scientific.net/amm.44-47.2897.

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After an extensive research on the fundamental theory, the theoretical basis for the Logix gearing will be presented in this paper. This includes the theory for gear meshing with high degree of contact. In comparison to previous studies, the theory of this paper is more restricted going beyond third order parameters into the fourth order, the teeth profile had one order of contact higher than that of the Logix gearing. So that further improved the contact strength of tooth profile. A large category of gearings with high order of contact was presented, while the Logix gear is only one of them,

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10

Bobic, Mirjana. "Modern rural family and household in Yugoslavia." Stanovnistvo 37, no. 1-4 (1999): 93–118. http://dx.doi.org/10.2298/stnv9904093b.

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The paper analyzes modern rural household in Yugoslavia, both by region and at the level of the country as a whole. The author begins by providing a statistical and sociological definition of basic terms, and proceeds with a combination of social and demographic analysis. The basic criterion used is the residential status of the population (permanent residence) based on the administrative distribution of settlements with the non-city ("other") population treated as part of rural population. The descriptive basis was formed on the basis of two types of sources: population census data and releva

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11

Wang, Jian, Liang Hou, and Shan Ming Luo. "The Generation Principle and Mathematical Models of a Novel Spherical Gear Drive." Advanced Materials Research 479-481 (February 2012): 1421–28. http://dx.doi.org/10.4028/www.scientific.net/amr.479-481.1421.

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A new type of spherical gear drive, which takes micro-segment involute profile as tooth profile, is presented in this paper. The generation principle of the spherical gear is described. The mathematical models including the equation of micro-segment involute profile, the equation of the conjugate tooth profile and the engagement equation, are established based on the meshing theory. This new type of spherical gear drive has the potential to improve the load capacity and the performance of spherical gear transmission.

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12

Carey, Megan E., Zoey I. Diaz, Martin Broadstock, Roderick Bailey, Adwoa D. Bentsi-Enchill, and Heidi J. Larson. "Toward Control? The Prospects and Challenges of Typhoid Conjugate Vaccine Introduction." Clinical Infectious Diseases 69, Supplement_5 (2019): S408—S411. http://dx.doi.org/10.1093/cid/ciz483.

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Abstract With a newly World Health Organization (WHO)–prequalified typhoid conjugate vaccine (TCV), Gavi funding for eligible countries, and a WHO policy recommendation for TCV use, now is the time for countries to introduce TCVs as part of an integrated typhoid control program, particularly in light of the increasing burden of antimicrobial resistance. Continued vaccine development efforts will lead to secure supply of low-cost vaccines, and ongoing vaccine studies will provide critical vaccine performance data and inform optimal deployment strategies, in both routine use and in outbreak sett

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13

Parajuli, Bibek, Kriti Acharya, Aakansha Nangarlia, et al. "Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate." Biochemical Journal 477, no. 21 (2020): 4263–80. http://dx.doi.org/10.1042/bcj20200495.

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We previously discovered a class of recombinant lectin conjugates, denoted lectin DLIs (‘dual-acting lytic inhibitors’) that bind to the HIV-1 envelope (Env) protein trimer and cause both lytic inactivation of HIV-1 virions and cytotoxicity of Env-expressing cells. To facilitate mechanistic investigation of DLI function, we derived the simplified prototype microvirin (MVN)-DLI, containing an MVN domain that binds high-mannose glycans in Env, connected to a DKWASLWNW sequence (denoted ‘Trp3’) derived from the membrane-associated region of gp41. The relatively much stronger affinity of the lecti

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14

Wu, Xiu Hai, and Wen Hua Chen. "Study on the Screw Rotor Profile of Non-Leakage Dry Screw Vacuum Pump." Applied Mechanics and Materials 321-324 (June 2013): 67–70. http://dx.doi.org/10.4028/www.scientific.net/amm.321-324.67.

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Through mathematical derivation based on screw engagement theory, the complete equations of the rotor profile with single thread, fixed pitch screws, trapezium and concave tooth surface were given. The end face profile of the pair screw rotor is conjugate and identical. The pair screw rotor form a meshing relationship by left hand and right hand. Finally, through modeling and simulation of meshing process by PRO/ENGINEER software, the profile equation is proved to be correct, the meshing line is completed, and operating the tooth surface interference does not occur in the course of meshing pro

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15

Hu, Liang Bin, Sheng Li, Feng Wei Yuan, Bi Wen Li, and Cong Gui Chen. "Slotting Profile Modification Technology and Generating Simulation’s MATLAB Implementation for Heavy-Loading Mine Gear." Advanced Materials Research 328-330 (September 2011): 574–78. http://dx.doi.org/10.4028/www.scientific.net/amr.328-330.574.

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Slotting process used to achieve modify heavy-loading mine gear.According to the pitch circle radius of gear tooth profile modification is difficult to accurately draw, reverse-designed the profile of the modification slotting cutter fold may occur on the cusp, generating simulation for slotting profile modification is implemented using MATLAB based on engagement theory of slotting process,which can test whether the pitch circle is set to reasonable, to avoid resulting the top or root of conjugate gear’s profiles be cut,achieved the adaptive design of profile modification slotting cutter.

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16

Maiti, Rathindranath. "A Novel Harmonic Drive With Pure Involute Tooth Gear Pair." Journal of Mechanical Design 126, no. 1 (2004): 178–82. http://dx.doi.org/10.1115/1.1637659.

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Consider commercially available “harmonic drives” or “strain wave gearings” (all patented designs). The tooth profiles of the mating pairs of teeth of the noncircular (pitch curve) flex gear and circular (pitch circle) ring gears are nearly conjugate and noninvolute. Evidently none of them offers ideal gear kinematics. In this paper, we propose a new wave generator (or cam) to drive flex gears of harmonic drives with fully conjugate gear pairs of purely involute profiles. The cam profile is made of circular arcs at the two diametrically opposite contact zones and shifted elliptical curves for

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17

Morin, Dominique, Sylvie Fortier, and Frédéric Deschenaux. "La conciliation travail-famille : un engagement pluriel qui se conjugue à l’indicatif présent et qui s’accorde au féminin." L'engagement des jeunes dans les diverses sphères de la vie Première partie 3, no. 2 (2021): 38–57. http://dx.doi.org/10.7202/1075735ar.

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18

Jolly, Clare, Kirk Kashefi, Michael Hollinshead, and Quentin J. Sattentau. "HIV-1 Cell to Cell Transfer across an Env-induced, Actin-dependent Synapse." Journal of Experimental Medicine 199, no. 2 (2004): 283–93. http://dx.doi.org/10.1084/jem.20030648.

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Direct cell–cell transfer is an efficient mechanism of viral dissemination within an infected host, and human immunodeficiency virus 1 (HIV-1) can exploit this mode of spread. Receptor recognition by HIV-1 occurs via interactions between the viral surface envelope glycoprotein (Env), gp120, and CD4 and a chemokine receptor, CCR5 or CXCR4. Here, we demonstrate that the binding of CXCR4-using HIV-1–infected effector T cells to primary CD4+/CXCR4+ target T cells results in rapid recruitment to the interface of CD4, CXCR4, talin, and lymphocyte function–associated antigen 1 on the target cell, and

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19

Fetvaci, Cuneyt. "Computerised Tooth Profile Generation of Conjugated Involute Internal Gears." Key Engineering Materials 572 (September 2013): 355–58. http://dx.doi.org/10.4028/www.scientific.net/kem.572.355.

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This paper studies the conjugated involute profile which are used in internal gear pumps. In this type of gear mechanisms, the internal gear profile is completely conjugate of the external gear profile. A composite line of action curve is obtained because the root fillets also play role in engagement cycle. The perfomance of the mechanism is increased. By applying consequent transformations, firstly the tooth surface of the generated external gear is obtained and secondly the tooth surface of the conjugated involute internal tooth surface is obtained. Also asymmetric tooth is considered. Mathe

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Zimmerman, Aukje W., Ben Joosten, Ruurd Torensma, Jane R. Parnes, Frank N. van Leeuwen, and Carl G. Figdor. "Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells." Blood 107, no. 8 (2006): 3212–20. http://dx.doi.org/10.1182/blood-2005-09-3881.

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Abstract Interactions between T cells and antigen-presenting cells (APCs) are the first step in the induction of an adaptive immune response. Here, we show that CD6 and its ligand activated leukocyte cell adhesion molecule (ALCAM) are actively recruited to the antigen-induced dendritic cell (DC)–T-cell contact zone. Moreover, ALCAM-blocking antibodies interfere with DC–T-cell conjugate formation, demonstrating that CD6-ALCAM binding is essential for stable T-cell–APC contact. We now demonstrate that besides their role in establishing initial contacts, CD6-ALCAM interactions are also required d

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Jolly, Clare, Ivonne Mitar, and Quentin J. Sattentau. "Adhesion Molecule Interactions Facilitate Human Immunodeficiency Virus Type 1-Induced Virological Synapse Formation between T Cells." Journal of Virology 81, no. 24 (2007): 13916–21. http://dx.doi.org/10.1128/jvi.01585-07.

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ABSTRACT Human immunodeficiency virus type 1 (HIV-1) can spread between CD4+ T cells by using a virological synapse (VS). The VS assembly is a cytoskeleton-driven process dependent on HIV-1 envelope glycoprotein (Env)-receptor engagement and is hypothesized to require adhesion molecule interactions. Here we demonstrate that leukocyte function-associated antigen 1 (LFA-1), intercellular adhesion molecule 1 (ICAM-1), and ICAM-3 are enriched at the VS and that inhibition of these interactions influences conjugate formation and reduces VS assembly. Moreover, CD4+ T cells deficient in LFA-1 or with

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Chen, Yi-Cheng, Yun-Hao Cheng, Jui-Tang Tseng, and Kun-Ju Hsieh. "Study of a harmonic drive with involute profile flexspline by two-dimensional finite element analysis." Engineering Computations 34, no. 7 (2017): 2107–30. http://dx.doi.org/10.1108/ec-03-2017-0086.

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Purpose This paper aims to present simulation results of a harmonic drive (HD) with involute flexspline (FS) profiles based on two-dimensional (2-D) finite element analysis (FEA). Design/methodology/approach First, the mathematical model of the FS with involute tooth profile was developed using a straight-edge rack cutter based on the theory of gearing. Then the engaging circular spline (CS) with conjugate tooth profile of FS was derived based on the enveloping theory and theory of gearing. Additionally, a mesh generation program was developed to discretize the FS based on the mathematical mod

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23

Henel, Gabriella, Karnail Singh, Dapeng Cui, et al. "Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin–like receptors." Blood 107, no. 11 (2006): 4449–57. http://dx.doi.org/10.1182/blood-2005-06-2519.

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AbstractKiller immunoglobulin–like receptors (KIRs) are a family of regulatory cell-surface molecules expressed on natural killer (NK) cells and memory T-cell subsets. Their ability to prevent the formation of an activation platform and to inhibit NK cell activation is the basis of the missing self model of NK cell function. The benefits of KIR expression for T-cell biology are unclear. We studied how KIR2DL2 regulates T-cell function. Engagement of KIR2DL2 by the ligand human leukocyte antigen (HLA)–Cw3 did not affect conjugate formation between CD4+KIR2DL2+ T cells and superantigen-pulsed ta

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Qamar, Farah Naz, Rabab Batool, Sonia Qureshi, et al. "Strategies to Improve Coverage of Typhoid Conjugate Vaccine (TCV) Immunization Campaign in Karachi, Pakistan." Vaccines 8, no. 4 (2020): 697. http://dx.doi.org/10.3390/vaccines8040697.

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The emergence and spread of extensively drug-resistant (XDR) typhoid in Karachi, Pakistan led to an outbreak response in Lyari Town, Karachi utilizing a mass immunization campaign with typhoid conjugate vaccine (TCV), Typbar TCV®. The mass immunization campaign, targeted Lyari Town, Karachi, one of the worst affected towns during the XDR typhoid outbreak. Here we describe the strategies used to improve acceptance and coverage of Typbar TCV in Lyari Town, Karachi. The mass immunization campaign with Typbar TCV was started as a school- and hospital-based vaccination campaign targeting children b

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Bucki, Robert, Katarzyna Leszczyńska, Fitzroy J. Byfield, et al. "Combined Antibacterial and Anti-Inflammatory Activity of a Cationic Disubstituted Dexamethasone-Spermine Conjugate." Antimicrobial Agents and Chemotherapy 54, no. 6 (2010): 2525–33. http://dx.doi.org/10.1128/aac.01682-09.

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ABSTRACT The rising number of antibiotic-resistant bacterial strains represents an emerging health problem that has motivated efforts to develop new antibacterial agents. Endogenous cationic antibacterial peptides (CAPs) that are produced in tissues exposed to the external environment are one model for the design of novel antibacterial compounds. Here, we report evidence that disubstituted dexamethasone-spermine (D2S), a cationic corticosteroid derivative initially identified as a by-product of synthesis of dexamethasone-spermine (DS) for the purpose of improving cellular gene delivery, functi

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26

Aggelidou, Chrysie, Theodossis A. Theodossiou, Antonio Ricardo Gonçalves, Mariza Lampropoulou та Konstantina Yannakopoulou. "A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry". Beilstein Journal of Organic Chemistry 10 (17 жовтня 2014): 2414–20. http://dx.doi.org/10.3762/bjoc.10.251.

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Grafting of δ-aminolevulinic acid (1) moieties on the narrow periphery of a β-cyclodextrin (β-CD) derivative through hydrolysable bonds was implemented, in order to generate a water-soluble, molecular/drug carrier with the capacity to undergo intracellular transformation into protoporphyrin IX (PpIX), an endogenous powerful photosensitizer for photodynamic therapy (PDT). The water-soluble derivative 2 was prepared by esterifying δ-azidolevulinic acid with heptakis(6-hydroxyethylamino-6-deoxy)-β-cyclodextrin, with an average degree of substitution, DS = 3. Delivery of water-soluble, colorless 2

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27

Lin, Chao, Yu Jie Hou, Qing Long Zeng, Hai Gong, Ling Nie, and Hua Qiu. "Study and Experimental Analysis of Oval Bevel Gear Transmission." Applied Mechanics and Materials 121-126 (October 2011): 2263–67. http://dx.doi.org/10.4028/www.scientific.net/amm.121-126.2263.

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Oval bevel gear is introduced as a new gear transmission type of intersecting axes, in which high-order, denaturing and eccentric one are included. Based on the theory of spatial engagement, spatial spherical coordinate system of the noncircular bevel gearing was developed and a generalized tooth profile equation of noncircular bevel gears was also proposed. The gear profile can be enveloped for the generating movement between conical cutter and oval bevel gear according to the envelope principle of conjugate profiles. Then a new and general parametric design method for oval bevel gear was fou

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28

Rigo, Rosa Maria, Maria Inês Côrte Vitória, and José António Marques Moreira. "Escritura acadêmica e engagement: limitações e potencialidades na elaboração dos trabalhos finais da graduação (Academic scripture and engagement: limitations and potentialities in the preparation of the final work of the graduation)." Revista Eletrônica de Educação 14 (April 13, 2020): 3417079. http://dx.doi.org/10.14244/198271993417.

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This article presents data from an action research, which sought to analyze limitations and potentialities in the course of the writing process of Graduation Course Completion Works. Using the content analysis (BARDIN, 2010), the results pointed limitations: 1) writing of textual genres needs to be practiced encouraged regularly; 2) promotion of the reading culture has become urgent since joining the university. The potentialities the study pointed out: 1) academic writing can become an important element in processes of student engagement; 2) the paired learning showed the improvement in the w

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Sun, Qiang, and Yuehai Sun. "The generation principle, mathematical models of variable involute, and its application." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 232, no. 5 (2017): 828–41. http://dx.doi.org/10.1177/0954406216688498.

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A novel generation method of tooth profile curve is presented in this paper. It introduces the concept of a variable involute whose curve is generated by the generating line rolling and slipping on the base circle simultaneously. The generation principle of variable involute is described and the equation of variable involute is deduced. Then, equations are established to synthesize a conjugate profile for the gear teeth, which include some restrictions to keep the involute meshing properties. With a selectable and arbitrary relative slippage which is defined as a slipping function, the variabl

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Ganesan, Rajkumar, Vijaykumar Chennupati, Balaji Ramachandran, Michael Riis Hansen, Sanjaya Singh та Iqbal S. Grewal. "Selective recruitment of γδ T cells by a bispecific antibody for the treatment of acute myeloid leukemia". Leukemia 35, № 8 (2021): 2274–84. http://dx.doi.org/10.1038/s41375-021-01122-7.

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AbstractDespite significant progress over the last few decades in the treatment of acute myeloid leukemia (AML), there still remains a major unmet medical need for this disease. Immunotherapy approaches for redirecting pan CD3+ T cells to target leukemia blasts have shown limited efficacy in clinical trials and often accompanied with severe toxicity in AML patients. We designed an alternative engager molecule (Anti-TRGV9/anti-CD123), a bispecific antibody that can simultaneously bind to the Vγ9 chain of the Vγ9Vδ2+ γδ T cell receptor and to AML target antigen, CD123, to selectively recruit Vγ9

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Miyazaki, Takahiro, Mekhala Maiti, Marlene Hennessy, et al. "NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy." Journal for ImmunoTherapy of Cancer 9, no. 5 (2021): e002024. http://dx.doi.org/10.1136/jitc-2020-002024.

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BackgroundNKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differences between endogenous IL-15 receptor α (IL-15Rα)-dependent (NKTR-255 and rhIL-15) and IL-15Rα-independent (precomplexed rhIL-15/IL-15Rα) cytokines.MethodsIn vitro pharmacological properties of rhIL-15, NKTR-255 and precomplex cytokines (rhIL-15/IL-15Rα and rhIL-15 N72D/IL-15Rα Fc) were investigated in receptor binding, signaling and cell function.

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Cyrulnik, B. "Déterminants neurologiques précoces des suicides à l’adolescence." European Psychiatry 28, S2 (2013): 60. http://dx.doi.org/10.1016/j.eurpsy.2013.09.158.

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On sait repérer les causes immédiates qui déclenchent le passage à l’acte suicidaire d’un adolescent. Il s’agit principalement d’un isolement social ou affectif face à une épreuve alarmante pour cette personne. Mais dans une population qui doit affronter cette épreuve, seuls ceux qui auront acquis une vulnérabilité neuro-émotionnelle, auront des idées suicidaires. L’acquisition de cette vulnérabilité est attribuable à un appauvrissement de la niche sensorielle qui entourait le bébé au cours des premiers mois de son existence. Pendant la grossesse, un trauma maternel augmente le taux de cortiso

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Johnson, Melissa Lynne, Anthony B. El-Khoueiry, Navid Hafez, et al. "CX-2029, a PROBODY drug conjugate targeting CD71 (transferrin receptor): Results from a first-in-human study (PROCLAIM-CX-2029) in patients (Pts) with advanced cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3502. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3502.

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3502 Background: CX-2029 is a PROBODY drug conjugate (PDC) of MMAE, a potent microtubule inhibitor, directed against CD71 (transferrin receptor 1). In addition to being an abundant tumor antigen, CD71 is highly expressed on normal cells, precluding targeting by a traditional antibody drug conjugate (ADC). PDCs are masked ADCs, unmasked predominantly by tumor-associated proteases, thereby restricting target engagement to tumors. Both a CD71 PDC and ADC displayed broad activity in multiple xenograft tumor models; in toxicology studies, the PDC was tolerable at doses consistent with efficacy in n

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Guo, Jian Hua, Hong Yuan Jiang, Yi Zhen Wu, Wen Ya Chu, and Qing Xin Meng. "Double Helical Synchronous Belt Transmission Design." Materials Science Forum 800-801 (July 2014): 672–77. http://dx.doi.org/10.4028/www.scientific.net/msf.800-801.672.

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The meshing impact noise caused by the gradually engagement between double helical synchronous belt and the pulley was reduced due to its spiral angle effect. Therefore, double helical synchronous belt transmission receives much concern with its excellent characteristics of de-noising, low transmission error and high carrying capacity. The profiles of synchronous belt and belt pulley were studied based on conjugate-curvature high degree contact meshing theory under the circumstance that the pitch of belt and belt pulley are identical. The higher contact strength of the belt teeth and a smaller

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Gosselin, C. J., and L. Cloutier. "The Generating Space for Parabolic Motion Error Spiral Bevel Gears Cut by the Gleason Method." Journal of Mechanical Design 115, no. 3 (1993): 483–89. http://dx.doi.org/10.1115/1.2919215.

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Because of their inherent pseudo-conjugate natures, spiral bevel gears cut by the Gleason method basically transmit motion in a nonuniform manner. This motion nonuniformity, or motion error, repeated at each tooth engagement and at high speeds and loads, can cause vibrations in transmissions and contact-entry impact loads on gear teeth which affect the life of a gearset. It is customary to make small changes to machine settings in order to produce gear pairs with vastly improved kinematics. Therefore, machine setting changes must be carefully chosen such as to produce appropriate unloaded kine

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Mosher, Janet E. "GROUNDING ACCESS TO JUSTICE THEORY AND PRACTICE IN THE EXPERIENCES OF WOMEN ABUSED BY THEIR INTIMATE PARTNERS." Windsor Yearbook of Access to Justice 32, no. 2 (2015): 149. http://dx.doi.org/10.22329/wyaj.v32i2.4688.

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For women seeking to extricate themselves from the web of entrapment woven together by the multiple threads that make up the coercive control repertoire of their abusive intimate partners, it is often difficult to avoid engagement with legal systems. Yet, the legal systems they encounter—criminal, family, child welfare, immigration among them—are frequently unwelcoming (if not hostile), controlling, demeaning, fragmented and contradictory. While there has been a recent explosion of interest in “access to justice,” little attention has been paid to how we might conceptualize access to justice i

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Sahu, Indrajit, and Michael H. Glickman. "Proteasome in action: substrate degradation by the 26S proteasome." Biochemical Society Transactions 49, no. 2 (2021): 629–44. http://dx.doi.org/10.1042/bst20200382.

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Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S proteasome. Additionally, a disordered segment on the substrate — either intrinsic or induced — is critical for proteasome engagement. The proteasome is geared to interact with both of these substrate features and prepare it for degradation. To facilitate substrate accessibility, resting proteasomes are characterised by a peripheral distribution of ubiquitin receptors on the 19S regulatory particle (RP) and a wide-open lateral surface on the ATPase ring. In this substrate accepting state, the internal ch

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Lafuente, Esther M., Mathew Salanga, Yoshiko Iwamoto, Lequn Li, and Vassiliki A. Boussiotis. "RIAM Regulates Actin Reorganization at the Immunological Synapse and Calcium Mobilization during T Cell Activation." Blood 108, no. 11 (2006): 1722. http://dx.doi.org/10.1182/blood.v108.11.1722.1722.

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Abstract Engagement of immune recognition subunits on lymphocytes results in cytoskeletal reorganization, polarization of polymerized actin, conjugate formation between T cells and APC, stabilization of the immunological synapse (IS), and initiation of signaling cascades leading to T cell activation. Actin remodeling is essential for these events and is mandatory for T cell activation. We have identified RIAM, a novel adaptor molecule that interacts specifically with active GTP-bound Rap1 and with regulators of the actin cytoskeleton Evl, VASP and Profilin. Profilin associates with G-actin and

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Majumdar, Shyama, Jaqueline C. Rinaldi, Neha R. Malhotra та ін. "Differential Actions of Estrogen Receptor α and β via Nongenomic Signaling in Human Prostate Stem and Progenitor Cells". Endocrinology 160, № 11 (2019): 2692–708. http://dx.doi.org/10.1210/en.2019-00177.

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Abstract Human prostate stem and progenitor cells express estrogen receptor (ER)α and ERβ and exhibit proliferative responses to estrogens. In this study, membrane-initiated estrogen signaling was interrogated in human prostate stem/progenitor cells enriched from primary epithelial cultures and stem-like cell lines from benign and cancerous prostates. Subcellular fractionation and proximity ligation assays localized ERα and ERβ to the cell membrane with caveolin-1 interactions. Exposure to 17β-estradiol (E2) for 15 to 60 minutes led to sequential phosphorylation of signaling molecules in MAPK

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Harrabi, Ons, Amy Chen, Emma Sangalang, et al. "615 Targeted immune cell activation by systemic delivery of toll-like receptor 9 agonist antibody conjugates induce potent anti-tumor immunity." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A651. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0615.

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BackgroundToll-like receptor (TLR) pathways play a crucial role in mounting potent innate immune responses against invading pathogens, as well as the subsequent engagement of adaptive immunity. Innate immune activation via the TLR9 pathway has potential for treating cancer as demonstrated clinically with TLR9 agonists administered intra-tumorally in melanoma patients.1 We developed a novel toll-like receptor agonist antibody conjugate (TRAAC) platform to systemically deliver a differentiated, targeted TLR9 agonist (T-CpG) for immune activation. The activation of TLR9 pathways can be directed s

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Budde, Lihua Elizabeth, Armen Mardiros, Wen-Chung Chang, et al. "Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy." Blood 122, no. 21 (2013): 1660. http://dx.doi.org/10.1182/blood.v122.21.1660.1660.

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Background Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. However, the potential for insertional mutagenesis and toxicities due to the infused cells have made development of safe Methods for removing transferred cells after treatment an important consideration. In addition, there is a lack of effective commercially available agents which allow for monitoring of CAR expression, tracking, isolating, and eliminating CAR- transduced cells. Therefore, adoptive T cell immunotherapy would benefit from a molecule whic

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Suck, Garnet, Suet-Mien Tan, Sixian Chu, Madelaine Niam, Tsyr Jong Lim, and Mickey Boon Chai Koh. "Comparative Analysis of LFA-1 Activation State and Functional Involvement in Enhanced Cytotoxicity of NK Cell Lines KHYG-1 and NK-92." Blood 112, no. 11 (2008): 4909. http://dx.doi.org/10.1182/blood.v112.11.4909.4909.

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Abstract Background: KHYG-1 and NK-92 are highly cytotoxic IL-2 dependent NK cell lines. NK cytotoxicity is regulated through an array of receptors with activating and inhibitory functions for spontaneous elimination of pathogen infected or tumor cells. Important roles have been described for the leukocyte function-associated antigen (LFA)- 1 adhesion receptor (αLβ2) in NK cytotoxicity. In T cells, the integrin LFA-1 occurs in a non-functional, bent form and requires activation, through divalent cations e.g., for ligand binding. In marked contrast, IL-2 stimulated NK cells could directly engag

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Lampe, Kurt. "Stiegler, Foucault, and Epictetus." Symposium 24, no. 2 (2020): 53–77. http://dx.doi.org/10.5840/symposium202024212.

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Why does Bernard Stiegler speak of “this culture, which I have named, after Epictetus, my melete?” In the first part of this article, I elucidate Stiegler’s claims about both Stoic exercises of reading and writing and their significance for the interpretive questions he has adapted from Michel Foucault and Jacques Derrida. In particular, I address the relations among care for oneself and others, the use of material technologies, and resistance to subjection or “freedom.” In the second part, I consider the merits and limitations of Stiegler’s comments about reading and writing in Stoicism, with

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Williams, Marna, Dongwei Li, Reina Fuji, et al. "Pharmacodynamics, Pharmacokinetics, and Tolerability of a B-Cell Specific Antibody-Targeted Chemotherapeutic Agent, Anti-CD79b-MCC-DM1, in Cynomolgus Monkeys." Blood 112, no. 11 (2008): 4974. http://dx.doi.org/10.1182/blood.v112.11.4974.4974.

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Abstract Antibody-based therapeutic approaches have revolutionized the treatment of non- Hodgkin’s lymphomas (NHL) as well as other hematological malignancies. However, given the biological and clinical heterogeneity of the diseases, a large variability in clinical response has been observed. Currently, patients with refractory or relapsed lymphomas have limited therapeutic options, and therefore the need to develop effective new treatments remains urgent. Antibody drug conjugates (ADC) may prove valuable in this respect. The B cell surface antigen, CD79b, is an attractive target for this appr

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Deckert, Jutta, Jose F. Ponte, Jennifer A. Coccia, et al. "Preclinical Mechanistic Studies Investigating Neutrophil and Lymphoid Cell Depletion By IMGN529, a CD37-Targeting Antibody-Drug Conjugate (ADC)." Blood 124, no. 21 (2014): 3119. http://dx.doi.org/10.1182/blood.v124.21.3119.3119.

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Abstract CD37 is a surface antigen widely expressed on malignant B cells in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). In normal tissues, CD37 expression is restricted to lymphoid tissues and blood cells, with high levels of expression on B lymphocytes and low levels on non-B lymphoid and myeloid cells. IMGN529 is a CD37-targeting ADC currently in a Phase I clinical study in adult patients with relapsed or refractory NHL (NCT01534715). This ADC uniquely combines the intrinsic pro-apoptotic and immune effector activities of its anti-CD37 antibody component with the poten

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Ng, Gordon, Thomas Spreter, Rupert Davies, and Grant Wickman. "ZW38, a Novel Azymetric Bispecific CD19-Directed CD3 T Cell Engager Antibody Drug Conjugate with Controlled T Cell Activation and Improved B Cell Cytotoxicity." Blood 128, no. 22 (2016): 1841. http://dx.doi.org/10.1182/blood.v128.22.1841.1841.

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Abstract Although blinatumomab is an approved treatment for Philadelphia chromosome negative relapsed or refractory (r/r) precursor-B cell ALL and is under development for r/r B cell NHL, blinatumomab has several limitations impacting fuller therapeutic utility. For instance, blinatumomab therapy requires continuous infusion due to its rapid clearance owing to its size and lack of an antibody Fc and has been associated with potentially life-threatening CNS toxicities and cytokine release syndrome (Viardot A et al, Blood 2016; Goebeler ME et al, J Clin Oncol 2016; Topp et al, Lancet Oncol 2015)

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Kim, Richard D., James M. Cleary, Alexis Diane Leal, et al. "A phase 1 study of TAK-164, an anti-guanylyl cyclase C (GCC) antibody-drug conjugate (ADC), in patients (pts) with advanced gastrointestinal (GI) cancers expressing GCC." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3050. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3050.

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3050 Background: TAK-164 is a second-generation ADC comprising a human IgG1 monoclonal antibody targeting GCC conjugated to a DNA-damaging alkylating agent by a peptide linker. TAK-164 demonstrated cytotoxic and antitumor activity in GCC-expressing cells and xenograft mouse models. This first-in-human study investigated the safety, pharmacokinetics (PK), and preliminary efficacy of TAK-164. Methods: Adult pts with GCC-positive, advanced/metastatic GI cancers received TAK-164 intravenously on day 1 of a 21-day cycle (Q3W). Dose escalation proceeded based on cycle 1 safety data via a Bayesian mo

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Metz, Heather, Ty Brender, Brenda Stevens, et al. "712 SBT6290, a systemically administered Nectin-4-directed TLR8 ImmunoTAC (TM) therapeutic, is a potent human myeloid cell agonist for the treatment of Nectin-4-expressing tumors." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A754. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0712.

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BackgroundSBT6290 is a novel therapeutic comprised of a selective TLR8 agonist conjugated to a Nectin-4-specific monoclonal antibody, designed for systemic delivery and tumor-localized activation of myeloid cells. Nectin-4 is a cell surface adhesion molecule that is overexpressed in multiple solid tumor types including triple negative breast, head and neck, lung, and urothelial cancers, with limited expression in normal tissues. Many solid tumors, including those expressing Nectin-4, are resistant to immunotherapy due to immune-suppressive mechanisms, loss of HLA, low neoantigen availability,

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Tai, Yu-Tzu, Chirag Acharya, Mike Y. Zhong та ін. "Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling". Blood 122, № 21 (2013): 681. http://dx.doi.org/10.1182/blood.v122.21.681.681.

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Abstract B cell maturation antigen (BCMA), a member of the tumor necrosis factor receptor superfamily (TNFRSF17), is selectively induced during plasma cell (PC) differentiation and is commonly expressed at high levels in malignant PCs. Using real time RT-PCR, we here first showed that BCMA mRNA was upregulated in CD138+ PCs from MM patients compared to normal healthy donors (p<0.04), consistent with high and restrictive BCMA expression in PCs but not normal tissues by gene expression profiling and immunohistochemistry (IHC) in a recent report (Clin Cancer Res 2013;19:2048-60). As a specific

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Salazar-Terreros, Myriam, Kleber Yotsumoto Fertrin, Fernando F. Costa, and Carla F. Franco-Penteado. "Crosstalk between Mast Cells and Eosinophils Can Contribute to Pathophysiology of Sickle Cell Anemia." Blood 132, Supplement 1 (2018): 1070. http://dx.doi.org/10.1182/blood-2018-99-119029.

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Abstract Introduction: Sickle cell anemia (SCA) is characterized by a chronic inflammatory state as a result of cellular activation and biochemical mediator release. Mast cell (MC) activation syndrome is recognized as a factor in the morbidity of SCA patients (Afrin 2014); in SCA murine models, MC activation and MC extracellular trap formation (Vincent et al, 2013; Tran et al 2017) are associated with neurogenic inflammation and nociceptor activation. Allergic models showed that MC activation induces selective release of preformed or newly synthesized compounds; these dynamics exhibit features

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