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1

Oraee, H. "Power engineering lines." Power Engineering Journal 1, no. 5 (1987): 252. http://dx.doi.org/10.1049/pe:19870046.

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2

Christiansen, Donald. "Spectral lines: Engineering anonymity." IEEE Spectrum 23, no. 8 (1986): 33. http://dx.doi.org/10.1109/mspec.1986.6371052.

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3

Mannion, Mike, and Hermann Kaindl. "Engineering Requirements in Product Lines." INCOSE International Symposium 21, no. 1 (June 2011): 3139–215. http://dx.doi.org/10.1002/j.2334-5837.2011.tb01308.x.

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4

Suhir, Ephraim. "Crossing the Lines." Mechanical Engineering 126, no. 09 (September 1, 2004): 39. http://dx.doi.org/10.1115/1.2004-sep-2.

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It is important that today’s outstanding engineer must have knowledge of many sciences and disciplines. Interdisciplinary skills help an engineer to cope with the changing social, economic, and political conditions that influence technology and its development. Nanotechnology and biotechnology remind us how important it is to be knowledgeable in many areas of applied science and engineering. A nanotechnology engineer should be well familiar with physics, materials science, surface chemistry, composites, quantum mechanics, materials, and mathematics. Biotechnology merges physics, engineering, and chemistry with biology, life sciences, and medicine. The multifaceted approach helps define and resolve problems in biomedical research and in clinical medicine for improved healthcare. The most surprising discoveries have been made at the boundaries of different disciplines. Alessandro Volta’s electric battery was a meeting of chemistry and physics.
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5

Lotter, Bruno. "Flexible assembly lines for precision engineering." Assembly Automation 5, no. 2 (February 1985): 103–9. http://dx.doi.org/10.1108/eb004658.

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6

Jézéquel, Jean-Marc. "Model-Driven Engineering for Software Product Lines." ISRN Software Engineering 2012 (December 18, 2012): 1–24. http://dx.doi.org/10.5402/2012/670803.

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Modeling variability in the context of software product-lines has been around for about 25 years in the research community. It started with Feature Modeling and soon enough was extended to handle many different concerns. Beyond being used for a mere description and documentation of variability, variability models are more and more leveraged to produce other artifacts, such as configurators, code, or test cases. This paper overviews several classification dimensions of variability modeling and explores how do they fit with such artifact production purposes.
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7

Thiel, Steffen, Muhammad Ali Babar, Goetz Botterweck, and Liam O'Brien. "Software Product Lines in Automotive Systems Engineering." SAE International Journal of Passenger Cars - Electronic and Electrical Systems 1, no. 1 (April 14, 2008): 531–43. http://dx.doi.org/10.4271/2008-01-1449.

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8

King, Alexander H. "Triple lines in materials science and engineering." Scripta Materialia 62, no. 12 (June 2010): 889–93. http://dx.doi.org/10.1016/j.scriptamat.2010.02.020.

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9

Lee, Jaejoon, Gerald Kotonya, and Daniel Robinson. "Engineering Service-Based Dynamic Software Product Lines." Computer 45, no. 10 (October 2012): 49–55. http://dx.doi.org/10.1109/mc.2012.284.

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10

Tonella, P., G. Antoniol, R. Fiutem, and F. Calzolari. "Reverse engineering 4.7 million lines of code." Software: Practice and Experience 30, no. 2 (February 2000): 129–50. http://dx.doi.org/10.1002/(sici)1097-024x(200002)30:2<129::aid-spe293>3.0.co;2-m.

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11

THORENS, BERNARD, PHILIPPE DUPRAZ, and SANDRA COTTET. "Engineering Tolerance into Transplanted β Cell Lines." Annals of the New York Academy of Sciences 944, no. 1 (January 25, 2006): 267–70. http://dx.doi.org/10.1111/j.1749-6632.2001.tb03838.x.

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12

Brovkina, Daniella, and Oliver Riedel. "Automatisierte Planung von Montagelinien/Model-Based Systems Engineering for Virtual Commissioning of Assembly Lines – Automated Planning of Assembly Lines." wt Werkstattstechnik online 110, no. 09 (2020): 591–96. http://dx.doi.org/10.37544/1436-4980-2020-09-21.

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Die virtuelle Inbetriebnahme repräsentiert eine etablierte Phase des Lebenszyklus eines modernen Produktionssystems, in der die Definition von Simulationsmodellen eine Schlüsselrolle spielt. Im Falle von Montagelinien erfolgt die Layoutplanung in Iterationen mit geringem Automatisierungsgrad, wodurch die Phase des Engineerings sowie eine anschließende Erstellung des virtuellen Inbetriebnahme-Modells verlangsamt wird. In diesem Beitrag wird ein Konzept für einen modellbasierten Ansatz zur vollautomatisierten Planung von Montagelinien vorgestellt, womit eine automatisierte Modellerstellung für die virtuelle Inbetriebnahme durch eine Zuordnung von Montageprozessmodellen bezüglich kompatiblen Fähigkeiten der Betriebsmittel erlaubt wird. &nbsp; Virtual commissioning represents an established phase in the life cycle of a modern production system, where the definition of simulation models plays a key role. In the case of assembly lines, layout planning is done in iterations with a low degree of automation, slowing down the engineering phase, and subsequent creation of the virtual commissioning model. In this paper, a concept for a model-based approach to fully automated planning of assembly lines is presented, enabling automated model generation for virtual commissioning by mapping assembly process models to compatible capabilities of the equipment.
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13

Frayne, Jan, Deborah E. Daniels, Jan Frayne, Timothy J. Satchwell, Joseph Hawksworth, Belinda K. Singleton, Tatyana N. Andrienko, et al. "Ex vivo Engineering of Red Blood Cells." Blood 134, Supplement_1 (November 13, 2019): SCI—5—SCI—5. http://dx.doi.org/10.1182/blood-2019-121117.

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Culture systems for human in vitro erythropoiesis are now well established. Using our 3-stage feeder-free erythroid culture system we can efficiently differentiate erythroid cells from adult and cord blood (CB) CD34+ cells with >105 fold expansion, enucleation rates of up to 95% and producing packed reticulocyte yields of >12ml post leukofiltration1. The final preparations for a first in man clinical trial of adult cultured reticulocytes produced under good manufacturing practice (RESTORE) are underway. Although we have shown that it is possible to modify the CD34+ derived cells using lentivirus for reengineering or additions to the medium, the finite proliferative capacity of CD34+ cells in culture currently limits yield. We therefore took the alternative approach of immortalising early erythroid cells differentiated from adult bone marrow (BM) CD34+ cells, creating the BEL-A (Bristol Erythroid Line Adult) line2, a sustainable erythroid cell source that recapitulates normal adult erythropoiesis, terminally differentiating to generate enucleated reticulocytes that express normal levels of adult globin. We have created a further 13 lines from BM, adult peripheral blood, CB and iPSC CD34+ cells, demonstrating reproducibility of the approach and its application to create lines from more accessible stem cell sources. Analysis of surface marker and globin profiles demonstrate the lines follow a similar differentiation profile to their respective primary cell source, with comparative proteomics confirming cell source representation of the lines. Lines always established at the pro-erythroblast/early basophilic stage, even when later stage erythroid cells were present in populations. As well as proof of principal as an alternative transfusion product and improved tools for studying erythropoiesis, such lines have far reaching additional applications, a number of which we are now exploring: Diagnostic and 'Universal' transfusion products: Presently serological testing by blood group reference laboratories relies on donated blood, which represent a finite resource and for some blood group phenotypes can be difficult to source. We used CRISPR-Cas9 gene editing to remove blood group antigens in order to generate a sustainable bank of cell lines with useful blood group phenotypes for diagnostic purposes3. Building on this, with the aim of developing a more compatible "universal" transfusion product to meet the needs of chronically transfused patients and those with rare blood group phenotypes, we used combinatorial gene targeting to create sublines deficient in multiple antigens responsible for the most common transfusion incompatibilities (ABO [Bombay], Rh [Rhnull], Kell [K0], Duffy [Fynull], GPB [S-s-U-]). Individual and multiple blood group knockout lines retained the ability to undergo terminal differentiation and enucleation, also illustrating the capacity for coexistence of multiple rare blood group phenotypes within viable reticulocytes3. Cytokine independent lines Cytokines represent a substantial cost contribution to erythroid culture systems. We therefore exploited activating mutations found in patient c-Kit and EPOR that cause hypersensitivity to ligand, to create cytokine independent lines thus increasing economic viability of cultured red cells. Bi-allelic EPOR or c-kit edits were introduced into BEL-A with confirmation and exploration of mechanism on differentiation in the absence, or with substantially reduced levels of cytokines. Model disease systems In addition to potential therapeutic applications we are also creating lines as model cellular disease systems for studying molecular mechanisms and as drug screening platforms, via CRISPR-Cas9 gene editing of BEL-A and by directly immortalising patient stem cells. To date we have made b-thalassemia major, HbE thalassemia and lines with KLF1 mutations. Furthermore, we have shown BEL-A reticulocytes support invasion and growth of Plasmodium falciparum and are utilising the line to study mechanisms of malaria parasite invasion4. Kupzig S, Parsons SF, Curnow E, Anstee DJ, Blair A. Superior survival of ex vivo cultured human reticulocytes following transfusion into mice. 2016;102:476-483Trakarnsanga K, Griffiths RE, Wilson MC, et al. An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells. Nat. Commun. 2017;8:14750Hawksworth J, Satchwell TJ, Meinders M, et al. Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing. EMBO Mol. Med. 2018; 10:e8454Satchwell TJ, Wright K, Haydn-Smith K, et al. Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements. Nat. Comm. 2019;10:3806 Disclosures No relevant conflicts of interest to declare.
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14

Cherbas, Lucy, Jennifer Hackney, Lei Gong, Claire Salzer, Eric Mauser, Dayu Zhang, and Peter Cherbas. "Tools for Targeted Genome Engineering of EstablishedDrosophilaCell Lines." Genetics 201, no. 4 (October 8, 2015): 1307–18. http://dx.doi.org/10.1534/genetics.115.181610.

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15

Bozhüyük, Kenan AJ, Jason Micklefield, and Barrie Wilkinson. "Engineering enzymatic assembly lines to produce new antibiotics." Current Opinion in Microbiology 51 (October 2019): 88–96. http://dx.doi.org/10.1016/j.mib.2019.10.007.

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16

Dutt, Kamla, and Yang Cao. "Engineering Retina from Human Retinal Progenitors (Cell Lines)." Tissue Engineering Part A 15, no. 6 (June 2009): 1401–13. http://dx.doi.org/10.1089/ten.tea.2007.0358.

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17

Hristoforou, E. "Magnetostrictive delay lines: engineering theory and sensing applications." Measurement Science and Technology 14, no. 2 (January 7, 2003): R15—R47. http://dx.doi.org/10.1088/0957-0233/14/2/201.

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18

Winn, M., J. K. Fyans, Y. Zhuo, and J. Micklefield. "Recent advances in engineering nonribosomal peptide assembly lines." Natural Product Reports 33, no. 2 (2016): 317–47. http://dx.doi.org/10.1039/c5np00099h.

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This reviews summarises progress towards the engineering of nonribosomal peptide synthetases (NRPS) from the expression of heterologous tailoring enzymes to direct modifications of the assembly lines to produce analogues. New techniques/tools for introducing changes are also examined.
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19

Carver, Jeffrey C., Eduardo Santana de Almeida, Rafael Capilla, Leandro Minku, Marco Torchiano, and Alejandro Valdezate. "Empirical Software Engineering, Predictive Models, and Product Lines." IEEE Software 35, no. 3 (May 2018): 8–11. http://dx.doi.org/10.1109/ms.2018.2141018.

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20

Sisó, G., M. Gil, F. Aznar, J. Bonache, and F. Martín. "Dispersion engineering with resonant-type metamaterial transmission lines." Laser & Photonics Reviews 3, no. 1-2 (September 12, 2008): 12–29. http://dx.doi.org/10.1002/lpor.200810026.

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21

Mellado, Daniel, Eduardo Fernández-Medina, and Mario Piattini. "Security requirements engineering framework for software product lines." Information and Software Technology 52, no. 10 (October 2010): 1094–117. http://dx.doi.org/10.1016/j.infsof.2010.05.007.

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22

McClenaghan, Neville H., and P. R. Flatt. "Engineering cultured insulin-secreting pancreatic B-cell lines." Journal of Molecular Medicine 77, no. 1 (January 1, 1999): 235–43. http://dx.doi.org/10.1007/s001090050344.

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23

Robinson, Tom, Bernie Rice, Walt Gray, Homer B. Tilton, and Virgil H. Soule. "Power Lines." Science News 153, no. 1 (January 3, 1998): 10. http://dx.doi.org/10.2307/4010173.

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24

Klopp, M., W. Kissling, and M. Spiewack. "Fractal lines." Manufacturing Engineer 76, no. 2 (April 1, 1997): 82–85. http://dx.doi.org/10.1049/me:19970202.

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25

Dragomir, Gabriel-Mugurel, Mariana Cernicova-Buca, Vasile Gherheș, and Liliana Cismariu. "Engineering Students’ Human Values as Rhizomatic Lines of Sustainability." Sustainability 12, no. 18 (September 9, 2020): 7417. http://dx.doi.org/10.3390/su12187417.

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The study reports on research carried out at the five major technical higher institutions in Romania. It views the human values students bring with them to the educational setting as rhizomatic lines, in the Deleuzian sense, and aims at identifying the intensity of each value, respectively, at grasping the correlations between the students’ values and their projection concerning postgraduation life, including nomadic (i.e., migration) intentions. Such an approach is novel in educational research. The 1782 valid responses collected after applying an online questionnaire were subjected to multivariate statistical analyses. The results unfold the research stages, from intensity-identification concerning the 18 values included in the questionnaire to the factor extraction and correlation findings that highlight strata beneath the upper layer of responses. The values boil down to three nodes of the rhizome, anchoring the Romanian engineers-to-be in the present setting and allowing them to grow in a sustainable manner, i.e., to become professionals, socially accepted, and belonging to a group. The findings are useful to professors, who need to constantly check their assumptions about the profile of the young generation, to better ground their partnership relation with students in moral realities that are relevant and help learners face disruption, crisis, incertitude.
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26

Méndez-Acuña, David, José A. Galindo, Benoît Combemale, Arnaud Blouin, and Benoît Baudry. "Reverse engineering language product lines from existing DSL variants." Journal of Systems and Software 133 (November 2017): 145–58. http://dx.doi.org/10.1016/j.jss.2017.05.042.

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27

Schilli, Bruno, Günther Mechler, Alexander Fay, Peter Bort, and Rainer Drath. "EFFICIENT ENGINEERING OF FLEXIBLE ASSEMBLY LINES IN DISCRETE MANUFACTURING." IFAC Proceedings Volumes 39, no. 3 (2006): 479–84. http://dx.doi.org/10.3182/20060517-3-fr-2903.00251.

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28

Kosaka, Y., N. Kobayashi, T. Okitsu, N. Tanaka, and T. Nakanishi. "IMMORTALIZED HUMAN MESENCHYMAL STEM CELL LINES FOR TISSUE ENGINEERING." ASAIO Journal 49, no. 2 (March 2003): 220. http://dx.doi.org/10.1097/00002480-200303000-00314.

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29

Ladner, Christopher C., and Gavin J. Williams. "Harnessing natural product assembly lines: structure, promiscuity, and engineering." Journal of Industrial Microbiology & Biotechnology 43, no. 2-3 (November 2, 2015): 371–87. http://dx.doi.org/10.1007/s10295-015-1704-8.

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30

DiGennaro, Richard, and Thomas Swain. "Engineering for high heat loads on ALS beam lines." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 291, no. 1-2 (May 1990): 313–18. http://dx.doi.org/10.1016/0168-9002(90)90078-k.

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31

Mellado, Daniel, Haralambos Mouratidis, and Eduardo Fernández-Medina. "Secure Tropos framework for software product lines requirements engineering." Computer Standards & Interfaces 36, no. 4 (June 2014): 711–22. http://dx.doi.org/10.1016/j.csi.2013.12.006.

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32

Wang Chunxiang, 王春香, 周国勇 Zhou Guoyong, and 刘流 Liu Liu. "Extracting Contour Lines of Point Cloud in Reverse Engineering." Laser & Optoelectronics Progress 57, no. 24 (2020): 242801. http://dx.doi.org/10.3788/lop57.242801.

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33

RITTER, STEPHEN K. "Blood Lines." Chemical & Engineering News 76, no. 47 (November 23, 1998): 48–49. http://dx.doi.org/10.1021/cen-v076n047.p048.

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34

Peng, Fei, and Honglin Li. "A Steganalysis Method for 2D Engineering Graphics Based on the Statistic of Geometric Features." International Journal of Digital Crime and Forensics 3, no. 2 (April 2011): 35–40. http://dx.doi.org/10.4018/jdcf.2011040103.

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Aiming at hiding information in 2D engineering graphics based on geometric features, a steganalysis method is proposed in this paper. First, the authors obtained the number of 2D engineering graphics’ strictly vertical and horizontal lines and identify the number of horizontal and vertical lines which are deviated from the straight line within a certain range. Subsequently, the authors selected the ratio between the deviated lines and the normal lines as the statistical characteristics. Finally, a detection model was constructed based on the hypothesis. Experimental results show that the algorithm can detect hidden information in the 2D engineering graphics effectively.
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35

JACQUEMOT, S., M. LOUIS-JACQUET, O. PEYRUSSE, M. CORNILLE, J. DUBAU, and P. LAUTARD. "SATELLITE LINES OF NEON-LIKE RESONANCE LINES, FOR 17." Le Journal de Physique Colloques 50, no. C1 (January 1989): C1–615—C1–622. http://dx.doi.org/10.1051/jphyscol:1989168.

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36

Walmsley, L. "Translating Conduction-Electron Spin-Resonance Lines into Lorentzian Lines." Journal of Magnetic Resonance, Series A 122, no. 2 (October 1996): 209–13. http://dx.doi.org/10.1006/jmra.1996.0196.

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37

Bonatti, Ivanil S., Pedro L. D. Peres, and Amauri Lopes. "Velocity of Propagation in Transmission Lines." International Journal of Electrical Engineering & Education 35, no. 1 (January 1998): 79–86. http://dx.doi.org/10.1177/002072099803500107.

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This paper discusses the skin effect on lossy transmission lines in the context of undergraduate electrical engineering courses. A new definition for propagation time derived from Parseval's theorem is proposed. In lossless transmission lines the proposed definition produces the conventional results and for lossy lines it matches quite exactly with the time simulation results, as shown by an illustrative example.
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38

Christiansen, Donald. "Spectral lines." IEEE Spectrum 24, no. 6 (1987): 27. http://dx.doi.org/10.1109/mspec.1987.6447890.

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39

Arey, Robert A., and Gordon Couger. "Fishy Punch Lines." Science News 156, no. 2 (July 10, 1999): 19. http://dx.doi.org/10.2307/4011595.

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40

Konovalenko, A. A., and S. V. Stepkin. "Radio recombination lines." EAS Publications Series 15 (2005): 271–95. http://dx.doi.org/10.1051/eas:2005158.

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41

Petcharawan, Supakanya, Nuttaphong Sornsuwit, and Wanlop Harnnarongchai. "Computer-Aided Design and Engineering for M16 Handguard Manufacturing." Key Engineering Materials 728 (January 2017): 422–27. http://dx.doi.org/10.4028/www.scientific.net/kem.728.422.

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This work presents a computer-aided design and engineering CAD/CAE for design and optimization of M16 handguard manufacturing. A new design of handguard was developed in term of various combinations of supporting ribs inside the component. Finite Element Analysis (FEA) was used to simulate the stress distribution as well as the evaluation of supporting ribs in the component. The injection molding was used for production of the hand guard; therefore, the CAE was used to simulate the effect of gate location and gate type on the weld lines. The excessive-flash technique, which extends the fill time and continues the melt lines to flow after the melt recombination, has been introduced in order to reduce the weld lines. The simulation results indicated that the stress concentration in the loading and vent holes regions had the potential to cause the handguard to fracture. However, the combinations of vertical and horizontal ribs can reduce the stress concentration in the component. The weld lines located near the vent hole, in which the melt fronts came in contact with each other. The type and location of gates did not affect the weld line while the weld lines were observed to be strongly influenced by the excessive flash.
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42

Miller, David, and Jacqueline Gulbis. "Engineering Protocells: Prospects for Self-Assembly and Nanoscale Production-Lines." Life 5, no. 2 (March 25, 2015): 1019–53. http://dx.doi.org/10.3390/life5021019.

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43

Kobayashi, H. "A Realistic Perspective of Architectural Engineering from the Front Lines." Concrete Journal 50, no. 1 (2012): 74–77. http://dx.doi.org/10.3151/coj.50.74.

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44

Kalkreuter, Edward, and Gavin J. Williams. "Engineering enzymatic assembly lines for the production of new antimicrobials." Current Opinion in Microbiology 45 (October 2018): 140–48. http://dx.doi.org/10.1016/j.mib.2018.04.005.

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45

Trisler, D., J. Rutin, and B. Pessac. "Retinal engineering: engrafted neural cell lines locate in appropriate layers." Proceedings of the National Academy of Sciences 93, no. 13 (June 25, 1996): 6269–74. http://dx.doi.org/10.1073/pnas.93.13.6269.

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46

Braun, Steven, Christian Bartelt, Martin Obermeier, Andreas Rausch, and Birgit Vogel-Heuser. "Requirements on Evolution Management of Product Lines in Automation Engineering." IFAC Proceedings Volumes 45, no. 2 (2012): 340–45. http://dx.doi.org/10.3182/20120215-3-at-3016.00060.

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47

Trisler, D., J. Rutin, and B. Pessac. "Retinal Engineering: Engrafted Neural Cell Lines Locate in Appropriate Layers." Retina 17, no. 5 (September 1997): 472–73. http://dx.doi.org/10.1097/00006982-199709000-00038.

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48

Batory, D. "Multilevel models in model-driven engineering, product lines, and metaprogramming." IBM Systems Journal 45, no. 3 (2006): 527–39. http://dx.doi.org/10.1147/sj.453.0527.

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49

Manns, Martin, and Nestor Andres Arteaga Martin. "A vagueness measure for concurrent engineering of manual assembly lines." Production Engineering 8, no. 1-2 (September 5, 2013): 225–31. http://dx.doi.org/10.1007/s11740-013-0494-y.

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50

Alves, Vander, Nan Niu, Carina Alves, and George Valença. "Requirements engineering for software product lines: A systematic literature review." Information and Software Technology 52, no. 8 (August 2010): 806–20. http://dx.doi.org/10.1016/j.infsof.2010.03.014.

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