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Journal articles on the topic 'Enhanced permeability and retention (EPR) effect'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Huang, Dong, Lingna Sun, Leaf Huang, and Yanzuo Chen. "Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect." Journal of Personalized Medicine 11, no. 2 (2021): 124. http://dx.doi.org/10.3390/jpm11020124.

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The use of nanomedicine for antitumor therapy has been extensively investigated for a long time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently regarded as an effective way to bring drugs to tumors, especially macromolecular drugs and drug-loaded pharmaceutical nanocarriers. However, a disordered vessel network, and occluded or embolized tumor blood vessels seriously limit the EPR effect. To augment the EPR effect and improve curative effects, in this review, we focused on the perspective of tumor blood vessels, and analyzed the relationship among abnormal

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2

Inagaki, Fuyuki F., Aki Furusawa, Peter L. Choyke, and Hisataka Kobayashi. "Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy." Nanophotonics 8, no. 10 (2019): 1673–88. http://dx.doi.org/10.1515/nanoph-2019-0186.

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AbstractTo date, the delivery of nanosized therapeutic agents to cancers largely relies on the enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. Whereas leaky vessels are often found in mouse xenografts, nanosized agents have demonstrated limited success in humans due to the relatively small magnitude of the EPR effect in naturally occurring cancers. To achieve the superior delivery of nanosized agents, alternate methods of increasing permeability and retention are needed. Near-infrared photoimmunotherapy (NIR-PIT) is a recently report

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3

Wu, Jun. "The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application." Journal of Personalized Medicine 11, no. 8 (2021): 771. http://dx.doi.org/10.3390/jpm11080771.

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Chemotherapy for human solid tumors in clinical practice is far from satisfactory. Despite the discovery and synthesis of hundreds of thousands of anticancer compounds targeting various crucial units in cancer cell proliferation and metabolism, the fundamental problem is the lack of targeting delivery of these compounds selectively into solid tumor tissue to maintain an effective concentration level for a certain length of time for drug-tumor interaction to execute anticancer activities. The enhanced permeability and retention effect (EPR effect) describes a universal pathophysiological phenom

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Tahara, Yu, Takuma Yoshikawa, Hikari Sato, et al. "Encapsulation of a nitric oxide donor into a liposome to boost the enhanced permeation and retention (EPR) effect." MedChemComm 8, no. 2 (2017): 415–21. http://dx.doi.org/10.1039/c6md00614k.

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We propose a method to improve the enhanced permeability and retention (EPR) effect of nanomedicines based on tumor-specific vasodilation using a nitric oxide (NO) donor-containing PEGylated liposome.

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Kobayashi, Hisataka, and Peter L. Choyke. "Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy." Nanoscale 8, no. 25 (2016): 12504–9. http://dx.doi.org/10.1039/c5nr05552k.

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6

Bonferoni, Maria Cristina, Giovanna Rassu, Elisabetta Gavini, et al. "Electrochemotherapy of Deep-Seated Tumors: State of Art and Perspectives as Possible “EPR Effect Enhancer” to Improve Cancer Nanomedicine Efficacy." Cancers 13, no. 17 (2021): 4437. http://dx.doi.org/10.3390/cancers13174437.

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Surgical resection is the gold standard for the treatment of many kinds of tumor, but its success depends on the early diagnosis and the absence of metastases. However, many deep-seated tumors (liver, pancreas, for example) are often unresectable at the time of diagnosis. Chemotherapies and radiotherapies are a second line for cancer treatment. The “enhanced permeability and retention” (EPR) effect is believed to play a fundamental role in the passive uptake of drug-loaded nanocarriers, for example polymeric nanoparticles, in deep-seated tumors. However, criticisms of the EPR effect were recen

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Keereweer, Stijn, Isabel M. Mol, Jeroen D. F. Kerrebijn, et al. "Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer." Journal of Surgical Oncology 105, no. 7 (2011): 714–18. http://dx.doi.org/10.1002/jso.22102.

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8

Fang, Jun, Rayhanul Islam, Waliul Islam, et al. "Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents." Pharmaceutics 11, no. 7 (2019): 343. http://dx.doi.org/10.3390/pharmaceutics11070343.

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One obstacle to the successful delivery of nanodrugs into solid tumors is the heterogeneity of an enhanced permeability and retention (EPR) effect as a result of occluded or embolized tumor blood vessels. Therefore, the augmentation of the EPR effect is critical for satisfactory anticancer nanomedicine. In this study, we focused on one vascular mediator involved in the EPR effect, carbon monoxide (CO), and utilized two CO generating agents, one is an extrinsic CO donor (SMA/CORM2 micelle) and another is an inducer of endogenous CO generation via heme oxygenase-1 (HO-1) induction that is carrie

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9

Kobayashi, Hisataka, Rira Watanabe, and Peter L. Choyke. "Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?" Theranostics 4, no. 1 (2014): 81–89. http://dx.doi.org/10.7150/thno.7193.

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10

Keereweer, S., I. M. Mol, J. D. F. Kerrebijn, A. L. Vahrmeijer, R. J. Baatenburg de Jong, and C. W. G. M. Lowik. "O125. Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer." Oral Oncology 47 (July 2011): S70—S71. http://dx.doi.org/10.1016/j.oraloncology.2011.06.236.

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11

Goos, Jeroen A. C. M., Andrew Cho, Lukas M. Carter, et al. "Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect." Theranostics 10, no. 2 (2020): 567–84. http://dx.doi.org/10.7150/thno.36777.

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12

Islam, Waliul, Shintaro Kimura, Rayhanul Islam, et al. "EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect." Journal of Personalized Medicine 11, no. 6 (2021): 487. http://dx.doi.org/10.3390/jpm11060487.

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For more than three decades, enhanced permeability and retention (EPR)-effect-based nanomedicines have received considerable attention for tumor-selective treatment of solid tumors. However, treatment of advanced cancers remains a huge challenge in clinical situations because of occluded or embolized tumor blood vessels, which lead to so-called heterogeneity of the EPR effect. We previously developed a method to restore impaired blood flow in blood vessels by using nitric oxide donors and other agents called EPR-effect enhancers. Here, we show that two novel EPR-effect enhancers—isosorbide din

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13

Maeda, Hiroshi. "The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery—Personal Remarks and Future Prospects." Journal of Personalized Medicine 11, no. 3 (2021): 229. http://dx.doi.org/10.3390/jpm11030229.

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This Special Issue on the enhanced permeability and retention (EPR) effect commemorates the 35th anniversary of its discovery, the original 1986 Matsumura and Maeda finding being published in Cancer Research as a new concept in cancer chemotherapy. My review here describes the history and heterogeneity of the EPR effect, which involves defective tumor blood vessels and blood flow. We reported that restoring obstructed tumor blood flow overcomes impaired drug delivery, leading to improved EPR effects. I also discuss gaps between small animal cancers used in experimental models and large clinica

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14

Rajora, Amit, Divyashree Ravishankar, Helen Osborn, and Francesca Greco. "Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates." Polymers 6, no. 8 (2014): 2186–220. http://dx.doi.org/10.3390/polym6082186.

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15

Boyd, Ben J., Adam Galle, Maria Daglas, Jeffrey V. Rosenfeld, and Robert Medcalf. "Traumatic brain injury opens blood–brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect." Journal of Drug Targeting 23, no. 9 (2015): 847–53. http://dx.doi.org/10.3109/1061186x.2015.1034280.

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16

Maeda, Hiroshi. "The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting." Advances in Enzyme Regulation 41, no. 1 (2001): 189–207. http://dx.doi.org/10.1016/s0065-2571(00)00013-3.

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17

Su, Yu-Lin, and Shang-Hsiu Hu. "Functional Nanoparticles for Tumor Penetration of Therapeutics." Pharmaceutics 10, no. 4 (2018): 193. http://dx.doi.org/10.3390/pharmaceutics10040193.

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Theranostic nanoparticles recently received great interest for uniting unique functions to amplify therapeutic efficacy and reduce side effects. Despite the enhanced permeability and retention (EPR) effect, which amplifies the accumulation of nanoparticles at the site of a tumor, tumor heterogeneity caused by the dense extracellular matrix of growing cancer cells and the interstitial fluid pressure from abnormal angiogenesis in the tumor inhibit drug/particle penetration, leading to inhomogeneous and limited treatments. Therefore, nanoparticles for penetrated delivery should be designed with d

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18

Miedema, Iris H. C., Gerben J. C. Zwezerijnen, Daniela E. Oprea-Lager, et al. "First-in-human imaging of nanoparticle entrapped docetaxel (CPC634) in patients with advanced solid tumors using 89Zr-Df-CPC634 PET/CT." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3093. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3093.

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3093 Background: CPC634 is a nanoparticle entrapping docetaxel designed to improve tumor accumulation and tolerability compared to conventionally administered docetaxel by taking advantage of the presumed enhanced permeability and retention (EPR) effect. In vivo imaging with zirconium-89 (89Zr)-desferal (Df)-CPC634 will provide valuable information on its biodistribution and will quantify tumor retention. Methods: Patients with solid tumors not amenable to standard therapy received 37 MBq, 0.1-2mg of 89Zr-Df-CPC634 tracer and whole body PET/CT scans were obtained at 2, 24 and 96h post-injectio

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19

Tanaka, T., S. Shiramoto, M. Miyashita, Y. Fujishima, and Y. Kaneo. "Tumor targeting based on the effect of enhanced permeability and retention (EPR) and the mechanism of receptor-mediated endocytosis (RME)." International Journal of Pharmaceutics 277, no. 1-2 (2004): 39–61. http://dx.doi.org/10.1016/j.ijpharm.2003.09.050.

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20

Yoshikawa, Takuma, Yukina Mori, Haitao Feng, et al. "Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect." International Journal of Pharmaceutics 565 (June 2019): 481–87. http://dx.doi.org/10.1016/j.ijpharm.2019.05.043.

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21

Salvioni, Lucia, Maria Antonietta Rizzuto, Jessica Armida Bertolini, Laura Pandolfi, Miriam Colombo, and Davide Prosperi. "Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope." Cancers 11, no. 12 (2019): 1855. http://dx.doi.org/10.3390/cancers11121855.

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Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanothe

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22

Kalyane, Dnyaneshwar, Nidhi Raval, Rahul Maheshwari, Vishakha Tambe, Kiran Kalia, and Rakesh K. Tekade. "Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer." Materials Science and Engineering: C 98 (May 2019): 1252–76. http://dx.doi.org/10.1016/j.msec.2019.01.066.

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23

Abdulbaqi, Ibrahim M., Reem Abou Assi, Anan Yaghmur, et al. "Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update." Pharmaceuticals 14, no. 8 (2021): 725. http://dx.doi.org/10.3390/ph14080725.

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Lung cancer (LC) is the leading cause of cancer-related deaths, responsible for approximately 18.4% of all cancer mortalities in both sexes combined. The use of systemic therapeutics remains one of the primary treatments for LC. However, the therapeutic efficacy of these agents is limited due to their associated severe adverse effects, systemic toxicity and poor selectivity. In contrast, pulmonary delivery of anticancer drugs can provide many advantages over conventional routes. The inhalation route allows the direct delivery of chemotherapeutic agents to the target LC cells with high local co

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24

Jiang, Ying, Chaoyang Guan, Xu Liu, et al. "Doxorubicin-Loaded CuS Nanoparticles Conjugated with GFLG: A Novel Drug Delivery System for Lymphoma Treatment." Nano 14, no. 01 (2019): 1950013. http://dx.doi.org/10.1142/s1793292019500139.

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Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NPs), their enhanced permeability and retention (EPR) effect, and surface modifiability. Nanocarriers can also be specifically enzymatically hydrolyzed by cathepsin (Cath) B, a kind of enzyme highly expressed in tumor cells. In this work, we proposed a novel drug delivery system comprising GFLG conjugated with copper sulfide (CuS) NPs loaded with DOX. The

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Cruz and Kayser. "Synthesis and Enhanced Cellular Uptake In Vitro of Anti-HER2 Multifunctional Gold Nanoparticles." Cancers 11, no. 6 (2019): 870. http://dx.doi.org/10.3390/cancers11060870.

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Nanoparticle carriers offer the possibility of enhanced delivery of therapeutic payloads in tumor tissues due to tumor-selective accumulation through the enhanced permeability and retention effect (EPR). Gold nanoparticles (AuNP), in particular, possess highly appealing features for development as nanomedicines, such as biocompatibility, tunable optical properties and a remarkable ease of surface functionalization. Taking advantage of the latter, several strategies have been designed to increase treatment specificity of gold nanocarriers by attaching monoclonal antibodies on the surface, as a

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Takashima, Hiroki, Shino Manabe, Atsushi Tsuji, et al. "ET-05 PRECLINICAL STUDY OF AN ANTI-HUMAN TISSUE FACTOR ANTIBODY-DRUG CONJUGATE IN A MALIGNANT GLIOMA XENOGRAFT MODEL." Neuro-Oncology Advances 1, Supplement_2 (2019): ii9. http://dx.doi.org/10.1093/noajnl/vdz039.039.

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Abstract Whereas macromolecules such as antibody hardly extravasate from normal blood vessels compared with low molecular agents, macromolecules leak from tumor vasculature because of the enhanced permeability. As a result, macromolecules selectively accumulate at tumor sites. We apply this phenomenon, known as the enhanced permeability and retention effect (EPR effect), to drug delivery for cancer therapy. Drug delivery system (DDS) based on the EPR effect is called the passive targeting. On the other hand, DDS based on antigen-antibody or ligand-receptor interaction is the active targeting.

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El-Diasty, Abdelrahman, Hamid Khattab, and Mahmoud Tantawy. "Application of Nanofluid Injection for Enhanced Oil Recovery (EOR)." Journal of University of Shanghai for Science and Technology 23, no. 08 (2021): 751–61. http://dx.doi.org/10.51201/jusst/21/08462.

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The use of nanofluids has been investigated and established for several applications in the oil and gas industry. Using nanoparticles for Enhanced Oil Recovery (EOR) applications underlines their small size in comparison with the size of the rock pore throats; consequently, they could easily transport into porous rocks with minimum retention effect and permeability reduction. Nanoparticles can significantly increase the oil recovery by enhancing both the fluid properties and fluid-rock interaction properties. In this study, commercial silica nanoparticles dispersions were used in standard core

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Guo, Wenna, Yongxing Du, Yanyang Wang, et al. "Study on array antennas combined with nanoparticles for enhanced microwave hyperthermia of breast cancer." Materials Express 10, no. 10 (2020): 1607–14. http://dx.doi.org/10.1166/mex.2020.1795.

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Tumor hyperthermia is to heat tumor tissue with biological thermal effect that can kill cancer cells when achieved effective treatment temperature. However, the temperature distribution of hyperthermia is uneven and it can not be accurately oriented to the tumor region. In this paper, an array antenna which can realize large-scale heating was designed for tumor microwave hyperthermia. ZrMOF-Cys nanoparticles (ZMC NPs) were prepared as the sensitizer of microwave hyperthermia. In the experiment of hyperthermia, array antenna and ZMC NPs are combined to achieve the goal of conformal hyperthermia

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Penketh, Philip G., Hugh S. Williamson, Raymond P. Baumann, and Krishnamurthy Shyam. "Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines." Molecules 26, no. 2 (2021): 259. http://dx.doi.org/10.3390/molecules26020259.

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A design strategy for macromolecular prodrugs is described, that are expected to exhibit robust activity against most solid tumor types while resulting in minimal toxicities to normal tissues. This approach exploits the enhanced permeability, and retention (EPR) effect, and utilizes carefully engineered rate constants to selectively target tumor tissue with short-lived cytotoxic moieties. EPR based tumor accumulation (half-life ~ 15 h) is dependent upon the ubiquitous abnormal solid tumor capillary morphology and is expected to be independent of individual tumor cell genetic variability that l

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Bisht, Gunjan, and Sagar Rayamajhi. "ZnO Nanoparticles: A Promising Anticancer Agent." Nanobiomedicine 3 (January 1, 2016): 9. http://dx.doi.org/10.5772/63437.

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Nanoparticles, with their selective targeting capabilities and superior efficacy, are becoming increasingly important in modern cancer therapy and starting to overshadow traditional cancer therapies such as chemotherapy radiation and surgery. ZnO nanoparticles, with their unique properties such as biocompatibility, high selectivity, enhanced cytotoxicity and easy synthesis, may be a promising anticancer agent. Zinc, as one of the major trace elements of the human body and co-factor of more than 300 mammalian enzymes, plays an important role in maintaining crucial cellular processes including o

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Shao, Pengyu, Bochu Wang, Yazhou Wang, Jun Li, and Yiqiong Zhang. "The Application of Thermosensitive Nanocarriers in Controlled Drug Delivery." Journal of Nanomaterials 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/389640.

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Thermosensitive nanocarriers as the “smart” drug delivery systems have shown tremendous promise in the field of controlled drug delivery due to their special property. Thermosensitive nanocarriers with long circulation properties can accumulate in the pathological sites by enhanced permeability and retention (EPR) effect or attach targeting ligands to the surface of the nanocarriers, and the drug release rates of these pharmaceutical nanocarriers can be adjusted in response to thermal variability of the environment. In this paper, we first discuss the classification of thermosensitive polymer

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Kumar, Akhil, Sankha Bhattacharya, Vikas Sharma, and Charan Singh. "Poly (Lactic-co-Glycolic Acid) & Tocopheryl Polyethylene Glycol Succinate Nanoparticles for the Treatment of Different Brain Cancers." Anti-Cancer Agents in Medicinal Chemistry 21, no. 15 (2021): 1977–86. http://dx.doi.org/10.2174/1871520621666210204201347.

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Nanotechnology and material science developments emerge in the manufacturing of various novel modes of drug delivery, which have proven scientifically promising. Polymer nanoparticles have high stability, high specificity, high drug-carrying power, control release, and potential to be used in various pathways. They usually supply hydrophilic and hydrophobic molecules with medicines. In this review, we have discussed the different types of brain tumour, different PLGA (Poly Lactic-co-Glycolic Acid) nanostructures, PLGA in brain tumour targeting, and the recent advancement of PLGA based nanopart

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Wu, Po-Ting, Chih-Ling Lin, Che-Wei Lin, Ning-Chu Chang, Wei-Bor Tsai, and Jiashing Yu. "Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells." Nanomaterials 9, no. 1 (2018): 14. http://dx.doi.org/10.3390/nano9010014.

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Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it is hard for the dye to penetrate through the cell membrane, leading to poor cellular uptake; thus, drug carriers, which could enhance the cellular uptake, are a suitable solution. In addition, the defective vessels resulting from fast vessel outgrowth leads to an enhanced permeability and retention (EPR) effect, which gives nanoscale drug carriers a promising potential. In this study, we applied poly(12-(methacryloy

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Haider, Mohamed, Amr Elsherbeny, Valeria Pittalà, Antonino N. Fallica, Maha Ali Alghamdi, and Khaled Greish. "The Potential Role of Sildenafil in Cancer Management through EPR Augmentation." Journal of Personalized Medicine 11, no. 6 (2021): 585. http://dx.doi.org/10.3390/jpm11060585.

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Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the path for the emerging field of nanomedicine to become a powerful tool in the fight against cancer. Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE-5) used for the treatment of erectile dysfunction (ED) through the relaxation of smooth muscles and the modulation of vascular endothelial permeability. Overexpression of PDE-5 has been reported in lung, colon, metastatic breast cancers, and bladder squamous carcinoma. Moreover, sildenafil has been reported to increase the sensitivity of

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Guo, Shutao, and Leaf Huang. "Nanoparticles Escaping RES and Endosome: Challenges for siRNA Delivery for Cancer Therapy." Journal of Nanomaterials 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/742895.

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Small interfering RNAs (siRNAs) technology has emerged as a promising potential treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles are rapidly cleared from the circulation by the reticuloendothelial system (RES). Second, following their cellular uptake, nanoparticles are trapped in endosomes/lysosomes, where siRNA would be degraded

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Kim, Daehyun, Seung Soo Lee, Woo Young Yoo, et al. "Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts." Pharmaceuticals 13, no. 9 (2020): 235. http://dx.doi.org/10.3390/ph13090235.

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Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address this issue, biocompatible nanoparticles have been developed to enhance the drug half-life while minimizing the associated toxicity. Nevertheless, relying solely on the enhanced half-life and enhanced permeability and retention (EPR) effects has been ineffective, and designing stimulus-sensitive nanoparticles to introduce the precise control of

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Weng, Xiaofu, Zhouzhou Bao, and Xunbin Wei. "Binary organic nanoparticles with enhanced reactive oxygen species generation capability for photodynamic therapy." Journal of Innovative Optical Health Sciences 14, no. 03 (2021): 2150009. http://dx.doi.org/10.1142/s1793545821500097.

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Photodynamic therapy (PDT) takes advantage of photosensitizers (PSs) to generate reactive oxygen species (ROS) for cell killing when excited by light. It has been widely used in clinic for therapy of multiple cancers. Currently, all the FDA-approved PSs, including porphyrin, are all small organic molecules, suffering from aggregation-caused quenching (ACQ) issues in biological environment and lacking tumor targeting capability. Nanoparticles (NPs) with size between 20[Formula: see text]nm and 200[Formula: see text]nm possess tumor targeting capability due to the enhanced permeability and reten

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Xu, Lei, Shuo Wu, and Xiaoqiu Zhou. "Bioinspired nanocarriers for an effective chemotherapy of hepatocellular carcinoma." Journal of Biomaterials Applications 33, no. 1 (2018): 72–81. http://dx.doi.org/10.1177/0885328218772721.

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Drug-loaded nanoparticles have been widely researched in the antitumor. However, some of them are unsatisfactory in the long blood circulation and controlled drug release. Red blood cell (RBC) membrane vesicles (RV)-coated nanoparticles have gained more and more attention in drug delivery for their many unique advantages, such as excellent stability, long blood circulation, and reduced the macrophage cells uptake. Herein, by utilizing the advantages of RV, we fabricated RV-coated poly(lactide- co-glycolide) (PLGA)–docetaxel (RV/PLGA/DTX) nanoparticles to enhance the antitumor efficiency in viv

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Kim, Choi, Choi, Park, and Ryu. "Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy." Pharmaceutics 11, no. 7 (2019): 301. http://dx.doi.org/10.3390/pharmaceutics11070301.

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Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, and nanoparticles) can be prepared easily using assembly and modification of its functional groups such as carboxy, hydroxy and N-acetyl groups. Nanometer-sized HA nanomedicines can selectively deliver drugs or other molecules into tumor sites via their enhanced permeability and retention (EPR)

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Xiang, Zhichu, Gexuan Jiang, Xiaoliang Yang, et al. "Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis." Biomolecules 9, no. 5 (2019): 172. http://dx.doi.org/10.3390/biom9050172.

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Improving the efficacy of nanoparticles (NPs) delivery to tumors is critical for cancer diagnosis and therapy. In our previous work, amphiphilic peptide APPA self-assembled nanocarriers were designed and constructed for cargo delivery to tumors with high efficiency. In this study, we explore the use of APPA self-assembled peptosomes as a nanoparticle adjuvant to enhance the delivery of nanoparticles and antibodies to integrin αvβ3 and neuropilin-1 (NRP1) positive tumors. The enhanced tumor delivery of coadministered NPs was confirmed by better magnetosome (Mag)-based T2-weighted magnetic reson

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Chang, Chih-Hsien, Ming-Cheng Chang, Ya-Jen Chang, Liang-Cheng Chen, Te-Wei Lee, and Gann Ting. "Translating Research for the Radiotheranostics of Nanotargeted 188Re-Liposome." International Journal of Molecular Sciences 22, no. 8 (2021): 3868. http://dx.doi.org/10.3390/ijms22083868.

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Nanoliposomes are one of the leading potential nano drug delivery systems capable of targeting chemotherapeutics to tumor sites because of their passive nano-targeting capability through the enhanced permeability and retention (EPR) effect for cancer patients. Recent advances in nano-delivery systems have inspired the development of a wide range of nanotargeted materials and strategies for applications in preclinical and clinical usage in the cancer field. Nanotargeted 188Re-liposome is a unique internal passive radiotheranostic agent for nuclear imaging and radiotherapeutic applications in va

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Bretin, Ludovic, Aline Pinon, Soukaina Bouramtane, et al. "Photodynamic Therapy Activity of New Porphyrin-Xylan-Coated Silica Nanoparticles in Human Colorectal Cancer." Cancers 11, no. 10 (2019): 1474. http://dx.doi.org/10.3390/cancers11101474.

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Photodynamic therapy (PDT) using porphyrins has been approved for treatment of several solid tumors due to the generation of cytotoxic reactive oxygen species (ROS). However, low physiological solubility and lack of selectivity towards tumor sites are the main limitations of their clinical use. Nanoparticles are able to spontaneously accumulate in solid tumors through an enhanced permeability and retention (EPR) effect due to leaky vasculature, poor lymphatic drainage, and increased vessel permeability. Herein, we proved the added value of nanoparticle vectorization on anticancer efficacy and

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Varani, Michela, Filippo Galli, Gabriela Capriotti, et al. "Theranostic Designed Near-Infrared Fluorescent Poly (Lactic-co-Glycolic Acid) Nanoparticles and Preliminary Studies with Functionalized VEGF-Nanoparticles." Journal of Clinical Medicine 9, no. 6 (2020): 1750. http://dx.doi.org/10.3390/jcm9061750.

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Poly-lactic-co-glycolic acid nanoparticles (PLGA-NPs) were approved by the Food and Drug Administration (FDA) for drug delivery in cancer. The enhanced permeability and retention (EPR) effect drives their accumulation minimizing the side effects of chemotherapeutics. Our aim was to develop a new theranostic tool for cancer diagnosis and therapy based on PLGA-NPs and to evaluate the added value of vascular endothelial growth factor (VEGF) for enhanced tumor targeting. In vitro and in vivo properties of PLGA-NPs were tested and compared with VEGF-PLGA-NPs. Dynamic light scattering (DLS) was perf

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Lv, Wei, Yamei Shen, Hengli Yang, et al. "A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer." Journal of Immunology Research 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/6202876.

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Nanobubble (NB), a newly developed nanoscaled ultrasound contrast agent (UCA) for molecular imaging, has been widely researched for these years. Targeting it with functional molecule, nanobubble can adhere selectively to cellular epitopes and receptors outside the vasculature via enhanced permeability and retention (EPR) effect of tumor blood vessel. To enhance the targeting rate of our previous prepared NBs-Affibody for HER2 (+) breast cancer imaging, we introduced a near-infrared fluorescent (NIRF) dye, IR783, in this study to enhance tumor-specific targeting rate and provide a promising mod

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Chytil, Petr, Libor Kostka, and Tomáš Etrych. "HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery." Journal of Personalized Medicine 11, no. 2 (2021): 115. http://dx.doi.org/10.3390/jpm11020115.

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Recently, numerous polymer materials have been employed as drug carrier systems in medicinal research, and their detailed properties have been thoroughly evaluated. Water-soluble polymer carriers play a significant role between these studied polymer systems as they are advantageously applied as carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, antimicrobial molecules, or multidrug resistance inhibitors. Covalent attachment of carried molecules using a biodegradable spacer is strongly preferred, as such design ensures the controlled release

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Bila, Alberto, Jan Åge Stensen, and Ole Torsæter. "Experimental Investigation of Polymer-Coated Silica Nanoparticles for Enhanced Oil Recovery." Nanomaterials 9, no. 6 (2019): 822. http://dx.doi.org/10.3390/nano9060822.

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Recently, polymer-coated nanoparticles were proposed for enhanced oil recovery (EOR) due to their improved properties such as solubility, stability, stabilization of emulsions and low particle retention on the rock surface. This work investigated the potential of various polymer-coated silica nanoparticles (PSiNPs) as additives to the injection seawater for oil recovery. Secondary and tertiary core flooding experiments were carried out with neutral-wet Berea sandstone at ambient conditions. Oil recovery parameters of nanoparticles such as interfacial tension (IFT) reduction, wettability altera

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Makimoto, Atsushi, Jun Fang, and Hiroshi Maeda. "Development of a Selective Tumor-Targeted Drug Delivery System: Hydroxypropyl-Acrylamide Polymer-Conjugated Pirarubicin (P-THP) for Pediatric Solid Tumors." Cancers 13, no. 15 (2021): 3698. http://dx.doi.org/10.3390/cancers13153698.

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Most pediatric cancers are highly chemo-sensitive, and cytotoxic chemotherapy has always been the mainstay of treatment. Anthracyclines are highly effective against most types of childhood cancer, such as neuroblastoma, hepatoblastoma, nephroblastoma, rhabdomyosarcoma, Ewing sarcoma, and so forth. However, acute and chronic cardiotoxicity, one of the major disadvantages of anthracycline use, limits their utility and effectiveness. Hydroxypropyl acrylamide polymer-conjugated pirarubicin (P-THP), which targets tumor tissue highly selectively via the enhanced permeability and retention (EPR) effe

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Yue, Xiuli, and Zhifei Dai. "Liposomal Nanotechnology for Cancer Theranostics." Current Medicinal Chemistry 25, no. 12 (2018): 1397–408. http://dx.doi.org/10.2174/0929867324666170306105350.

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Liposomes are a type of biomimetic nanoparticles generated from self-assembling concentric lipid bilayer enclosing an aqueous core domain. They have been attractive nanocarriers for the delivery of many drugs (e.g. radiopharmaceuticals, chemotherapeutic agents, porphyrin) and diagnostic agents (e.g. fluorescent dyes, quantum dots, Gadolinium complex and Fe3O4) by encapsulating (or adsorbing) hydrophilic one inside the liposomal aqueous core domain (or on the bilayer membrane surface), and by entrapping hydrophobic one within the liposomal bilayer. Additionally, the liposome surface can be easi

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Gao, Shanghui, Rayhanul Islam, and Jun Fang. "Tumor Environment-Responsive Hyaluronan Conjugated Zinc Protoporphyrin for Targeted Anticancer Photodynamic Therapy." Journal of Personalized Medicine 11, no. 2 (2021): 136. http://dx.doi.org/10.3390/jpm11020136.

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Targeted tumor accumulation, tumor environment responsive drug release, and effective internalization are critical issues being considered in developing anticancer nanomedicine. In this context, we synthesized a tumor environment-responsive nanoprobe for anticancer photodynamic therapy (PDT) that is a hyaluronan conjugated zinc protoporphyrin via an ester bond (HA-es-ZnPP), and we examined its anticancer PDT effect both in vitro and in vivo. HA-es-ZnPP exhibits high water-solubility and forms micelles of ~40 nm in aqueous solutions. HA-es-ZnPP shows fluorescence quenching without apparent 1O2

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Baker, Abu, Mohd Salman Khan, Muhammad Zafar Iqbal, and Mohd Sajid Khan. "Tumor-targeted Drug Delivery by Nanocomposites." Current Drug Metabolism 21, no. 8 (2020): 599–613. http://dx.doi.org/10.2174/1389200221666200520092333.

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Background: Tumor-targeted delivery by nanoparticles is a great achievement towards the use of highly effective drug at very low doses. The conventional development of tumor-targeted delivery by nanoparticles is based on enhanced permeability and retention (EPR) effect and endocytosis based on receptor-mediated are very demanding due to the biological and natural complications of tumors as well as the restrictions on the design of the accurate nanoparticle delivery systems. Methods: Different tumor environment stimuli are responsible for triggered multistage drug delivery systems (MSDDS) for t

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