Log in

Relevant bibliographies by topics / Enoyl Acyl Carrier Protein Reductase / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Enoyl Acyl Carrier Protein Reductase.

Dissertations / Theses on the topic 'Enoyl Acyl Carrier Protein Reductase'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 15 dissertations / theses for your research on the topic 'Enoyl Acyl Carrier Protein Reductase.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Muench, Stephen. "Structural studies of enoyl acyl carrier protein reductase from Plasmodium falciparum and Toxoplasma gondii." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419663.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Fisher, Martin. "Structural studies of #beta#-keto acyl carrier protein reductase from Escherichia coli and Brassica napus." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Thomas, Neil Ciaron. "Over-expression and characterisation of Brassica napus and Escherichia coli 3-oxoacyl-[acyl carrier protein] reductase." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4586/.

Full text

Abstract:

A full length cDNA clone of Brassica napus 3-oxoacyl-ACP reductase (β-ketoacyl-ACP reductase; E.C. 1.1.1.100; βKR) and the Escherichia coli gene for the same enzyme, have been over-expressed in E. coli. Both the Brassica napus seed and Escherichia coli βKR proteins have been purified by a rapid two-step, single chromatography matrix method. Glutaraldehyde cross-linking studies show the plant βKR is expressed as a tetramer and the E. coli enzyme is expressed as a dimer. The secondary structure of the two proteins was predicted via analysis of circular dichroism spectra, which also show dilution

APA, Harvard, Vancouver, ISO, and other styles

4

Young, Clare Elisabeth. "Examination of the Brassica napus β-Keto-acyl carrier protein reductase promoter for regulatory cis-acting elements". Thesis, Durham University, 2002. http://etheses.dur.ac.uk/4024/.

Full text

Abstract:

Major interest has focused on the identification of regulatory factors involved in lipid biosynthesis. This study examined the B.napus β-Keto-ACP reductase 5' sequence for potential regulatory cis-acting elements. The 5' sequence of the most highly expressed Brassica napus β-Keto-ACP reductase isoform was fused to the reporter gene β-glucuronidase (GUS) and its expression pattern examined within transgenic Arabidopsis. The construct was shown to act as a functional promoter and direct transcription within embryos, cotyledons and roots. There was no apparent staining within the true leaves, but

APA, Harvard, Vancouver, ISO, and other styles

5

Warner, Nikita. "Transcriptional Regulation of the Glycogen Phosphorylase-2 Gene in Dictyostelium discoideum." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/29050.

Full text

Abstract:

The expression of the <I>glycogen phosphorylase- 2</I> gene (<I>gp2</I>) is initiated during early development and regulated by the extracellular morphogens cAMP and Differentiation Inducing Factor (DIF-1) [1-3]. Glycogen phosphorylase- 2 catalyzes the breakdown of glycogen reserves in developing cells to generate glucose precursors required for the synthesis of the end products of differentiation [4-6]. Thus, the expression of <I>gp2</I> is a significant event for cellular differentiation. The sequence of the <I>gp2</I> promoter, like other <I>Dictyostelium</I> promoters, has an AT-rich

APA, Harvard, Vancouver, ISO, and other styles

6

Ferraro, Antonio. "Entwicklung potenzieller (ir-)reversibler Inhibitoren der Enoyl-ACP-Reduktase FabI in S. aureus/ E. coli und der Thiolase FadA5 in M. tuberculosis." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-23839.

Full text

Abstract:

Antimikrobielle Resistenzen stellen eine weltweite Herausforderung dar und sind mit einer hohen Morbidität und Mortalität verbunden. Die Letalitätsrate durch multiresistente Keime steigt stetig an, weshalb die WHO im Jahr 2017 eine Prioritätenliste resistenter Keime erstellte, die die Entwicklung neuer Antibiotika vorantreiben soll. Diese umfasst vornehmlich gramnegative Bakterien, da diese aufgrund ihres Zellaufbaus sowie diverser Resistenzmechanismen besonders widerstandsfähig gegenüber dem Angriff vieler Antibiotika sind. Einige grampositive Keime (z.B. S. aureus) stehen ebenfalls auf diese

APA, Harvard, Vancouver, ISO, and other styles

7

Narkhede, Yogesh. "In silico structure-based optimisation of pyrrolidine carboxamides as Mycobacterium tuberculosis enoyl-ACP reductase inhibitors." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-152468.

Full text

Abstract:

The high infection rates and recent emergence of extremely drug resistant forms of Mycobacterium tuberculosis pose a significant challenge for global health. The NADH- dependent enoyl-ACP-reductase InhA of the type II mycobacterial fatty acid biosynthesis pathway is a well-validated target for inhibiting mycobacterial growth. InhA has been shown to be inhibited by a variety of compound series. Prominent classes of InhA inhibitors from literature include diaryl ethers, pyrrolidine carboxamides and arylamides which can be subjected to further development. Despite the progress in this area, very

APA, Harvard, Vancouver, ISO, and other styles

8

Waltenberger, Constanze Ricarda Maria. "Virtuelles Screening nach einer neuen Inhibitorklasse der Enoyl-ACP-Reduktase InhA aus Mycobacterium tuberculosis." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-73736.

Full text

Abstract:

Die Zahl der Tuberkuloseerkrankungen ist in den letzten Jahrzehnten weltweit gestiegen. Da es an innovativen Antituberkulotika mangelt, werden nach wie vor Medikamente der ersten Generation eingesetzt. Das wachsende Problem sind multi-resistente und extrem-resistente Bakterienstämme, die kaum oder gar nicht auf die medikamentöse Therapie ansprechen. Charakteristisch für M. tuberculosis ist eine dicke Zellwand. Der Aufbau der Zellwand ermöglicht es dem Bakterium in den Makrophagen zu persistieren und sich dort zu vermehren. Die Zellwand ist reich an Mykolsäuren und so wenig durchlässig für Frem

APA, Harvard, Vancouver, ISO, and other styles

9

Vogel, Simon. "Untersuchungen von Thiazolidindionen und verwandten Fünfringheterozyklen als Leitstruktur potenzieller Inhibitoren der Enoyl-ACP-Reduktase InhA des Mycobacterium tuberculosis." Doctoral thesis, 2015. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-113792.

Full text

Abstract:

Weltweit zählt die Tuberkulose zu den tödlichsten und am weitesten verbreiteten Infektionskrankheiten. Missstände in der ohnehin komplexen Therapie einerseits und fehlende Entwicklung neuartiger adäquater Wirkstoffe andererseits, führten zur Entstehung von multi- und sogar total-resistenten Keimen. Der Haupterreger ist das Mycobacterium tuberculosis. Charakteristisch für Mykobakterien ist eine dicke und undurchlässige wachsartige Zellwand mit einem großen Anteil an bestimmten Fettsäuren. Die mykobakterielle Biosynthese dieser Fettsäuren unterscheidet sich stark von eukaryotischen Zellen. Die s

APA, Harvard, Vancouver, ISO, and other styles

10

Schiebel, Johannes. "Structure-Based Drug Design on Enzymes of the Fatty Acid Biosynthesis Pathway." Doctoral thesis, 2013. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-69239.

Full text

Abstract:

Während die Wirkung der meisten gebräuchlichen Antibiotika auf einer Beeinträchtigung wichtiger bakterieller Prozesse beruht, wirken manche Substanzen durch die Störung der Zellmembran-Struktur. Da Fettsäuren ein essentieller Bestandteil von Membran-Phospholipiden sind, stellt die bakterielle Fettsäurebiosynthese II (FAS-II) einen relativ wenig erforschten, aber dennoch vielversprechenden Angriffspunkt für die Entwicklung neuer Antibiotika dar. Das wichtige Antituberkulotikum Isoniazid blockiert die mykobakterielle Fettsäurebiosynthese und ruft dadurch morphologische Änderungen sowie letztlich

APA, Harvard, Vancouver, ISO, and other styles

11

Merget, Benjamin. "Computational methods for assessing drug-target residence times in bacterial enoyl-ACP reductases and predicting small-molecule permeability for the \(Mycobacterium\) \(tuberculosis\) cell wall." Doctoral thesis, 2015. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-127386.

Full text

Abstract:

\textbf{Molecular Determinants of Drug-Target Residence Times of Bacterial Enoyl-ACP Reductases.} Whereas optimization processes of early drug discovery campaigns are often affinity-driven, the drug-target residence time $t_R$ should also be considered due to an often strong correlation with \textit{in vivo} efficacy of compounds. However, rational optimization of $t_R$ is not straightforward and generally hampered by the lack of structural information about the transition states of ligand association and dissociation. The enoyl-ACP reductase FabI of the fatty acid synthesis (FAS) type II is a

APA, Harvard, Vancouver, ISO, and other styles

12

Maity, Koustav. "Structure Analysis Of FabI And FabZ Enzymes Of The Fatty Acid Biosynthesis Pathway Of Plasmodium Falciparum." Thesis, 2010. https://etd.iisc.ac.in/handle/2005/2221.

Full text

Abstract:

The emergence of drug resistant strains of Plasmodium has given a new face to the old disease, malaria. One of the approaches is to block metabolic pathways of the pathogen. The current thesis describes the X-ray crystallographic analysis of two enzymes of the fatty acid biosynthesis pathway of the malaria parasite Plasmodium falciparum. In order to understand the functional mechanism and mode of inhibitor binding, enzyme-inhibitor complexes were characterized, which could help in further improvement of the efficacy of the inhibitors and hence to fight against the disease. The introductory

APA, Harvard, Vancouver, ISO, and other styles

13

Maity, Koustav. "Structure Analysis Of FabI And FabZ Enzymes Of The Fatty Acid Biosynthesis Pathway Of Plasmodium Falciparum." Thesis, 2010. http://hdl.handle.net/2005/2221.

Full text

Abstract:

The emergence of drug resistant strains of Plasmodium has given a new face to the old disease, malaria. One of the approaches is to block metabolic pathways of the pathogen. The current thesis describes the X-ray crystallographic analysis of two enzymes of the fatty acid biosynthesis pathway of the malaria parasite Plasmodium falciparum. In order to understand the functional mechanism and mode of inhibitor binding, enzyme-inhibitor complexes were characterized, which could help in further improvement of the efficacy of the inhibitors and hence to fight against the disease. The introductory c

APA, Harvard, Vancouver, ISO, and other styles

14

Kumar, Gyanendra. "Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery." Thesis, 2007. https://etd.iisc.ac.in/handle/2005/589.

Full text

Abstract:

Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb to death annually. Worst affected are the children below 5 years of age in sub-Saharan Africa. Plasmodium is a protozoan parasite classified under the phylum Apicomplexa that also includes parasites such as Toxoplasma, Lankestrella, Eimeria and Cryptosporidium. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, Plasmodi

APA, Harvard, Vancouver, ISO, and other styles

15

Kumar, Gyanendra. "Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery." Thesis, 2007. http://hdl.handle.net/2005/589.

Full text

Abstract:

Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb to death annually. Worst affected are the children below 5 years of age in sub-Saharan Africa. Plasmodium is a protozoan parasite classified under the phylum Apicomplexa that also includes parasites such as Toxoplasma, Lankestrella, Eimeria and Cryptosporidium. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, Plasmodi

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!