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Journal articles on the topic 'Enoyl Acyl Carrier Protein Reductase'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

MARRAKCHI, Hedia, Walter E. DeWOLF, Chad QUINN, et al. "Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK)." Biochemical Journal 370, no. 3 (2003): 1055–62. http://dx.doi.org/10.1042/bj20021699.

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The enoyl-(acyl-carrier protein) (ACP) reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. An extensively characterized NADH-dependent reductase, FabI, is widely distributed in bacteria and plants, whereas the enoyl-ACP reductase, FabK, is a distinctly different member of this enzyme group discovered in Streptococcus pneumoniae. We were unable to delete the fabK gene from Strep. pneumoniae, suggesting that this is the only enoyl-ACP reductase in this organism. The FabK enzyme was purified and the biochemical properties of the red

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2

Tallorin, Lorillee, Kara Finzel, Quynh G. Nguyen, Joris Beld, James J. La Clair, and Michael D. Burkart. "Trapping of the Enoyl-Acyl Carrier Protein Reductase–Acyl Carrier Protein Interaction." Journal of the American Chemical Society 138, no. 12 (2016): 3962–65. http://dx.doi.org/10.1021/jacs.5b13456.

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3

Kumarachari, Rajasekhar Komarla, Mayandigari Guruvareddy, M. Phebe, et al. "Design, Synthesis, Anti-tubercular and Docking Studies of Novel 2-Furanyl-3-substituted Quinazolin-4-one Derivatives." Asian Journal of Chemistry 35, no. 3 (2023): 617–23. http://dx.doi.org/10.14233/ajchem.2023.27482.

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In this work, the synthesis, characterization and the anti-tubercular activity of novel 2-furanyl-3- substituted quinazolin-4-one derivatives and also predicted their affinity against Mycobacterium tuberculosis enoyl acyl carrier protein reductase were carried out. The targeted compounds were synthesized by the condensation of 2-(furan-2-yl)-4(3H)-1-benzoxazine-4-one with different primary amines. After structural elucidation using spectral data, the compounds were screened for anti-tubercular activity against Mycobacterium tuberculosis H37RV strain. The binding affinity against enoyl acyl car

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4

Massengo-Tiassé, R. Prisca, and John E. Cronan. "Vibrio cholerae FabV Defines a New Class of Enoyl-Acyl Carrier Protein Reductase." Journal of Biological Chemistry 283, no. 3 (2007): 1308–16. http://dx.doi.org/10.1074/jbc.m708171200.

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Enoyl-acyl carrier protein (ACP) reductase catalyzes the last step of the fatty acid elongation cycle. The paradigm enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan. However, some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK and FabL. The genome of the Gram-negative bacterium, Vibrio cholerae lacks a gene encoding a homologue of any of the three known enoyl-ACP reductase isozymes suggesting that this organism encodes a novel fou

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5

SLABAS, A. R., C. SIDEBOTTOM, R. KESSELL, A. HELLYER, and M. P. TOMBS. "Oilseed rape NADH enoyl acyl-carrier protein reductase." Biochemical Society Transactions 14, no. 3 (1986): 581–82. http://dx.doi.org/10.1042/bst0140581.

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6

Honeyman, G., and T. Fawcett. "Protein interactions of fatty acid synthase II." Biochemical Society Transactions 28, no. 6 (2000): 615–16. http://dx.doi.org/10.1042/bst0280615.

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We have used a yeast two-hybrid approach to detect direct protein interactions between fatty acid synthase components. Enoyl-acyl carrier protein (ACP) reductase was found to interact with stearoyl-ACP desaturase and acyl-ACP thioesterase, but none of these proteins interacted with ACP in the yeast nucleus.

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7

Toraskar, Mrunmayee P., and Priyanka P. Kamble. "Enoyl Acyl Carrier Protein Reductase Inhibitors: An Emerging Target." International Journal of ChemTech Research 11, No. 07 (2018): 123–33. http://dx.doi.org/10.20902/ijctr.2018.110715.

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8

Tallorin, Lorillee, Jacob D. Durrant, Quynh G. Nguyen, J. Andrew McCammon, and Michael D. Burkart. "Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase." Bioorganic & Medicinal Chemistry 22, no. 21 (2014): 6053–61. http://dx.doi.org/10.1016/j.bmc.2014.09.002.

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9

Zhu, Lei, Jinshui Lin, Jincheng Ma, John E. Cronan, and Haihong Wang. "Triclosan Resistance of Pseudomonas aeruginosa PAO1 Is Due to FabV, a Triclosan-Resistant Enoyl-Acyl Carrier Protein Reductase." Antimicrobial Agents and Chemotherapy 54, no. 2 (2009): 689–98. http://dx.doi.org/10.1128/aac.01152-09.

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ABSTRACT Triclosan, a very widely used biocide, specifically inhibits fatty acid synthesis by inhibition of enoyl-acyl carrier protein (ACP) reductase. Escherichia coli FabI is the prototypical triclosan-sensitive enoyl-ACP reductase, and E. coli is extremely sensitive to the biocide. However, other bacteria are resistant to triclosan, because they encode triclosan-resistant enoyl-ACP reductase isozymes. In contrast, the triclosan resistance of Pseudomonas aeruginosa PAO1 has been attributed to active efflux of the compound (R. Chuanchuen, R. R. Karkhoff-Schweizer, and H. P. Schweizer, Am. J.

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10

Elborough, K. M., R. Swinhoe, R. Winz, et al. "Isolation of cDNAs from Brassica napus encoding the biotin-binding and transcarboxylase domains of acetyl-CoA carboxylase: assignment of the domain structure in a full-length Arabidopsis thaliana genomic clone." Biochemical Journal 301, no. 2 (1994): 599–605. http://dx.doi.org/10.1042/bj3010599.

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One independent and two overlapping rape cDNA clones have been isolated from a rape embryo library. We have shown that they encode a 2.3 kb and a 2.5 kb stretch of the full-length acetyl-CoA carboxylase (ACCase) cDNA, corresponding to the biotin-binding and transcarboxylase domains respectively. Using the cDNA in Northern-blot analysis we have shown that the mRNA for ACCase has a higher level of expression in rape seed than in rape leaf and has a full length of 7.5 kb. The level of expression during rape embryogenesis was compared with both oil deposition and expression of two fatty acid synth

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11

Rafferty, John B., Martin Fisher, Sarah J. Langridge та ін. "Crystallization of the NADP-dependent β-keto acyl carrier protein reductase from Escherichia coli". Acta Crystallographica Section D Biological Crystallography 54, № 3 (1998): 427–29. http://dx.doi.org/10.1107/s0907444997013668.

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The NADP-dependent β-keto acyl carrier protein reductase (BKR) from E. coli has been crystallized by the hanging-drop method of vapour diffusion using poly(ethylene glycol) of average molecular weight 1450. The crystals belong to the hexagonal space group P6122 or P6522 with unit-cell dimensions a = b = 67.8, c = 355.8 Å. Calculated values for Vm and consideration of the packing suggest that the asymmetric unit contains a dimer. BKR catalyses the first reductive step in the elongation cycle of fatty-acid biosynthesis. It shares extensive sequence homology with the enzyme which catalyzes the se

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12

Torkko, Juha M., Kari T. Koivuranta, Ilkka J. Miinalainen, et al. "Candida tropicalis Etr1p andSaccharomyces cerevisiae Ybr026p (Mrf1′p), 2-Enoyl Thioester Reductases Essential for Mitochondrial Respiratory Competence." Molecular and Cellular Biology 21, no. 18 (2001): 6243–53. http://dx.doi.org/10.1128/mcb.21.18.6243-6253.2001.

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ABSTRACT We report here on the identification and characterization of novel 2-enoyl thioester reductases of fatty acid metabolism, Etr1p fromCandida tropicalis and its homolog Ybr026p (Mrf1′p) fromSaccharomyces cerevisiae. Overexpression of these proteins in S. cerevisiae led to the development of significantly enlarged mitochondria, whereas deletion of the S. cerevisiae YBR026c gene resulted in rudimentary mitochondria with decreased contents of cytochromes and a respiration-deficient phenotype. Immunolocalization and in vivo targeting experiments showed these proteins to be predominantly mit

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13

Yao, Jiangwei, Megan E. Ericson, Matthew W. Frank, and Charles O. Rock. "Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes." Infection and Immunity 84, no. 12 (2016): 3597–607. http://dx.doi.org/10.1128/iai.00647-16.

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Enoyl-acyl carrier protein reductase catalyzes the last step in each elongation cycle of type II bacterial fatty acid synthesis and is a key regulatory protein in bacterial fatty acid synthesis. Genes of the facultative intracellular pathogenListeria monocytogenesencode two functional enoyl-acyl carrier protein isoforms based on their ability to complement the temperature-sensitive growth phenotype ofEscherichia colistrain JP1111 [fabI(Ts)]. The FabI isoform was inactivated by the FabI selective inhibitor AFN-1252, but the FabK isoform was not affected by the drug, as expected. Inhibition of F

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14

Hoang, Tung T., and Herbert P. Schweizer. "Characterization of Pseudomonas aeruginosa Enoyl-Acyl Carrier Protein Reductase (FabI): a Target for the Antimicrobial Triclosan and Its Role in Acylated Homoserine Lactone Synthesis." Journal of Bacteriology 181, no. 17 (1999): 5489–97. http://dx.doi.org/10.1128/jb.181.17.5489-5497.1999.

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ABSTRACT The Pseudomonas aeruginosa fabI structural gene, encoding enoyl-acyl carrier protein (ACP) reductase, was cloned and sequenced. Nucleotide sequence analysis revealed that fabIis probably the last gene in a transcriptional unit that includes a gene encoding an ATP-binding protein of an ABC transporter of unknown function. The FabI protein was similar in size and primary sequence to other bacterial enoyl-ACP reductases, and it contained signature motifs for the FAD-dependent pyridine nucleotide reductase and glucose/ribitol dehydrogenase families, respectively. The chromosomal fabIgene

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15

Vick, Jacob E., James M. Clomburg, Matthew D. Blankschien, Alexander Chou, Seohyoung Kim та Ramon Gonzalez. "Escherichia coli Enoyl-Acyl Carrier Protein Reductase (FabI) Supports Efficient Operation of a Functional Reversal of the β-Oxidation Cycle". Applied and Environmental Microbiology 81, № 4 (2014): 1406–16. http://dx.doi.org/10.1128/aem.03521-14.

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ABSTRACTWe recently used a synthetic/bottom-up approach to establish the identity of the four enzymes composing an engineered functional reversal of the β-oxidation cycle for fuel and chemical production inEscherichia coli(J. M. Clomburg, J. E. Vick, M. D. Blankschien, M. Rodriguez-Moya, and R. Gonzalez, ACS Synth Biol 1:541–554, 2012,http://dx.doi.org/10.1021/sb3000782). While native enzymes that catalyze the first three steps of the pathway were identified, the identity of the native enzyme(s) acting as thetrans-enoyl coenzyme A (CoA) reductase(s) remained unknown, limiting the amount of pro

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16

Saxena, D., G. Kaul, A. Dasgupta, and S. Chopra. "Afabicin. Enoyl-(acyl-carrier-protein) reductase FabI inhibitor, Antibacterial drug." Drugs of the Future 46, no. 1 (2021): 5. http://dx.doi.org/10.1358/dof.2021.46.1.3179432.

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17

Moir, Donald. "Identification of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase." Current Drug Target -Infectious Disorders 5, no. 3 (2005): 297–305. http://dx.doi.org/10.2174/1568005054880154.

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18

Massengo-Tiassé, R. P., and J. E. Cronan. "Diversity in enoyl-acyl carrier protein reductases." Cellular and Molecular Life Sciences 66, no. 9 (2009): 1507–17. http://dx.doi.org/10.1007/s00018-009-8704-7.

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19

Marrakchi, H., Y. M. Zhang, and C. O. Rock. "Mechanistic diversity and regulation of Type II fatty acid synthesis." Biochemical Society Transactions 30, no. 6 (2002): 1050–55. http://dx.doi.org/10.1042/bst0301050.

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Fatty acid biosynthesis is catalysed in most bacteria by a group of highly conserved proteins known as the Type II fatty acid synthase (FAS) system. The Type II system organization is distinct from its mammalian counterpart and offers several unique sites for selective inhibition by antibacterial agents. There has been remarkable progress in the understanding of the genetics, biochemistry and regulation of Type II FASs. One important advance is the discovery of the interaction between the fatty acid degradation regulator, FadR, and the fatty acid biosynthesis regulator, FabR, in the transcript

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20

Ruswanto, Ruswanto, Nur Rahayuningsih, Nur Laeli Dwi Hidayati, Ginna Sri Nuryani, and Richa Mardianingrum. "Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr." JURNAL ILMU KEFARMASIAN INDONESIA 17, no. 2 (2019): 218. http://dx.doi.org/10.35814/jifi.v17i2.703.

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Telah dilakukannya penelitian tentang studi in vitro dan in silico senyawa turunan N-Benzoylisonicotinohydrazide. Penelitian ini bertujuan untuk mengetahui bahwa senyawa turunan N’-benzoylisonicotinohydrazide dapat menghambat aktivitas bakteri gram positif, gram negatif dan Mycobacterium tuberculosis, serta mempunyai interaksi yang baik dengan Enoyl-Acyl Carrier Protein Reductase dari Mycobacterium Tuberculosis. Dari uji in vitro dihasilkan bahwa senyawa N’-benzoylisonicotinohydrazide memiliki Minimum Inhibitor Concentration (MIC) sebesar 0,33 µg/ml terhadap bakteri Basillus subtilis, sedangka

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21

Lu, Xiaoyun, Kun Huang, and Qidong You. "Enoyl acyl carrier protein reductase inhibitors: a patent review (2006 – 2010)." Expert Opinion on Therapeutic Patents 21, no. 7 (2011): 1007–22. http://dx.doi.org/10.1517/13543776.2011.581227.

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22

Park, Hee Soo, Yu Min Yoon, Sung Ji Jung, et al. "CG400462, a new bacterial enoyl–acyl carrier protein reductase (FabI) inhibitor." International Journal of Antimicrobial Agents 30, no. 5 (2007): 446–51. http://dx.doi.org/10.1016/j.ijantimicag.2007.07.006.

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23

Al-Madhagi, Haitham. "In silico evaluation of natural bioactive compounds as Mycobacterium leprae enoyl acyl carrier protein reductase inhibitors." Journal of Chemistry and Nutritional Biochemistry 3, no. 1 (2022): 1–10. http://dx.doi.org/10.48185/jcnb.v3i1.512.

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Background and Objectives: The present study was designed to assess the antileprotic effectiveness of some bioactive natural compounds towards enoyl acyl carrier protein reductase inhibition. Leprosy still constitutes a global pandemic in spite of long years of discovery. The current therapy option is multi-drug treatment using a combination of Dapsone, Rifampicin and Clofazimine. However, mycobacterium leprae counteracted by mutating the drug targets which necessitates the search for novel targets. One such target is enoyl acyl carrier protein reductase that mediates the fatty acid bios

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24

Fisher, Martin, Svetlana E. Sedelnikova, Wayne Martindale та ін. "Crystallization of the NADP-dependent β-keto acyl-carrier protein reductase from Brassica napus". Acta Crystallographica Section D Biological Crystallography 56, № 1 (2000): 86–88. http://dx.doi.org/10.1107/s0907444999013918.

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The NADP-dependent β-keto acyl-carrier protein reductase (BKR) from Brassica napus has been crystallized by the hanging-drop vapour-diffusion method using polyethylene glycol of average molecular weight 1500 as the precipitant. The crystals belong to the hexagonal space group P6422, with unit-cell parameters a = b = 129.9, c = 93.1 Å, α = β = 90, γ = 120°. Calculated values for Vm , the use of rotation and translation functions and consideration of the packing suggest that the asymmetric unit contains a monomer. The crystals diffract to beyond 2.8 Å resolution and are more amenable to X-ray di

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25

Zitko, Jan, and Martin Doležal. "Enoyl acyl carrier protein reductase inhibitors: an updated patent review (2011 – 2015)." Expert Opinion on Therapeutic Patents 26, no. 9 (2016): 1079–94. http://dx.doi.org/10.1080/13543776.2016.1211112.

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26

Ling, Losee L., Jun Xian, Syed Ali, et al. "Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase." Antimicrobial Agents and Chemotherapy 48, no. 5 (2004): 1541–47. http://dx.doi.org/10.1128/aac.48.5.1541-1547.2004.

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ABSTRACT Bacterial enoyl-acyl carrier protein reductase (ENR) catalyzes an essential step in fatty acid biosynthesis. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes. High-throughput screening to identify inhibitors of Escherichia coli ENR yielded four structurally distinct classes of hits. Several members of one of

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27

Khare, Dheeraj, Wendi A. Hale, Ashootosh Tripathi, et al. "Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase." Structure 23, no. 12 (2015): 2213–23. http://dx.doi.org/10.1016/j.str.2015.09.013.

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28

de Boer, Gert-Jan, Gerlof J. A. Pielage, H. John J. Nijkamp, et al. "Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine." Molecular Microbiology 31, no. 2 (1999): 443–50. http://dx.doi.org/10.1046/j.1365-2958.1999.01182.x.

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29

Pinzi, Luca, Christian Lherbet, Michel Baltas, Federica Pellati, and Giulio Rastelli. "In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA)." Molecules 24, no. 14 (2019): 2567. http://dx.doi.org/10.3390/molecules24142567.

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Cannabigerol (CBG) and cannabichromene (CBC) are non-psychoactive cannabinoids that have raised increasing interest in recent years. These compounds exhibit good tolerability and low toxicity, representing promising candidates for drug repositioning. To identify novel potential therapeutic targets for CBG and CBC, an integrated ligand-based and structure-based study was performed. The results of the analysis led to the identification of CBG as a low micromolar inhibitor of the Enoyl acyl carrier protein (ACP) reductase (InhA) enzyme.

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30

Pamudi, Berwi Fazri, Azizahwati Azizahwati, and Arry Yanuar. "IN-SILICO SCREENING AGAINST ANTIMALARIAL TARGET PLASMODIUM FALCIPARUM ENOYL-ACYL CARRIER PROTEIN REDUCTASE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 17 (2017): 127. http://dx.doi.org/10.22159/ajpcr.2017.v10s5.23114.

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Objective: Malaria is a parasitic infection that causes worldwide health problems. The absence of an effective vaccine and Plasmodium strains that are resistant to antimalarial drugs emphasize the importance of developing new chemotherapeutic agents. The use of computers for in-silico screening, or virtual screening, is currently being developed as a method for discovering antimalarial drugs. One of the enzymes that can support the development of the malaria parasite is the Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR). Inhibition of these enzymes leads to Type II lipid bi

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31

Sun, Zhi-Gang, Yun-Jie Xu, Jian-Fei Xu, Qi-Xing Liu, Yu-Shun Yang, and Hai-Liang Zhu. "Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase." Chemical and Pharmaceutical Bulletin 67, no. 2 (2019): 125–29. http://dx.doi.org/10.1248/cpb.c18-00663.

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32

Dayan, Franck E., Daneel Ferreira, Yan-Hong Wang, Ikhlas A. Khan, John A. McInroy, and Zhiqiang Pan. "A Pathogenic Fungi Diphenyl Ether Phytotoxin Targets Plant Enoyl (Acyl Carrier Protein) Reductase." Plant Physiology 147, no. 3 (2008): 1062–71. http://dx.doi.org/10.1104/pp.108.118372.

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33

Khan, Shazia, Sathya Narayanan Nagarajan, Amit Parikh, et al. "Phosphorylation of Enoyl-Acyl Carrier Protein Reductase InhA Impacts Mycobacterial Growth and Survival." Journal of Biological Chemistry 285, no. 48 (2010): 37860–71. http://dx.doi.org/10.1074/jbc.m110.143131.

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34

Ziegler, Angelika, Sybil M. Macintosh, Lesley Torrance, William Simon, and Antony R. Slabas. "Recombinant antibody fragments that detect enoyl acyl carrier protein reductase in Brassica napus." Lipids 32, no. 8 (1997): 805–9. http://dx.doi.org/10.1007/s11745-997-0103-3.

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35

Xu, Jian-Fei, Tian-Tian Wang, Qing Yuan, et al. "Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase." Bioorganic & Medicinal Chemistry 27, no. 8 (2019): 1509–16. http://dx.doi.org/10.1016/j.bmc.2019.02.043.

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36

He, Xin, Akram Alian, and Paul R. Ortiz de Montellano. "Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides." Bioorganic & Medicinal Chemistry 15, no. 21 (2007): 6649–58. http://dx.doi.org/10.1016/j.bmc.2007.08.013.

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37

Ozawa, Tomohiro, Hideo Kitagawa, Yasuo Yamamoto, et al. "Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK." Bioorganic & Medicinal Chemistry 15, no. 23 (2007): 7325–36. http://dx.doi.org/10.1016/j.bmc.2007.08.050.

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38

Kim, Su Jin, Byung Hak Ha, Kook-Han Kim, et al. "Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus." Biochemical and Biophysical Research Communications 400, no. 4 (2010): 517–22. http://dx.doi.org/10.1016/j.bbrc.2010.08.083.

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39

Rafferty, John B., J. William Simon, Antoine R. Stuitje, Antoni R. Slabas, Tony Fawcett, and David W. Rice. "Crystallization of the NADH-specific Enoyl Acyl Carrier Protein Reductase from Brassica napus." Journal of Molecular Biology 237, no. 2 (1994): 240–42. http://dx.doi.org/10.1006/jmbi.1994.1225.

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40

González-Thuillier, Irene, Mónica Venegas-Calerón, Rafael Garcés, Penny von Wettstein-Knowles, and Enrique Martínez-Force. "Sunflower (Helianthus annuus) fatty acid synthase complex: enoyl-[acyl carrier protein]-reductase genes." Planta 241, no. 1 (2014): 43–56. http://dx.doi.org/10.1007/s00425-014-2162-7.

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41

Lokesh, Bontha Venkata Subrahmanya, Y. Rajendra Prasad, and Afzal Basha Shaik. "Synthesis, Biological Evaluation and Molecular Docking Studies of New Pyrazolines as an Antitubercular and Cytotoxic Agents." Infectious Disorders - Drug Targets 19, no. 3 (2019): 310–21. http://dx.doi.org/10.2174/1871526519666181217120626.

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Background: Many synthetic procedures were reported till date to prepare pyrazoline derivatives. Some have published pyrazolines from different chalcone derivatives in the literature. Objective: A series of new pyrazolines containing novel 2,5-dichloro-3-acetylthiophene chalcone moiety (PZT1-PZT20) have been synthesized, characterized by 1HNMR and 13CNMR and evaluated for them in vitro antitubercular activity against M. tuberculosis H37Rv strain and in vitro anticancer activity against DU-145 prostate cancer cell lines and all compounds were also screened for molecular docking studies against

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42

Ghattas, Mohammad A., Nermin A. Eissa, Sanaa K. Bardaweel, Abdallah Abu Mellal, and Noor Atatreh. "Computer-aided discovery of antimicrobial agents as potential enoyl acyl carrier protein reductase inhibitors." Tropical Journal of Pharmaceutical Research 16, no. 2 (2017): 397. http://dx.doi.org/10.4314/tjpr.v16i2.19.

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43

Yang, Liang, Yang Liu, Claus Sternberg, and Søren Molin. "Evaluation of Enoyl-Acyl Carrier Protein Reductase Inhibitors as Pseudomonas aeruginosa Quorum-Quenching Reagents." Molecules 15, no. 2 (2010): 780–92. http://dx.doi.org/10.3390/molecules15020780.

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44

de Ávila, Maurício Boff, Gabriela Bitencourt-Ferreira, and Walter Filgueira de Azevedo. "Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis." Current Medicinal Chemistry 27, no. 5 (2020): 745–59. http://dx.doi.org/10.2174/0929867326666181203125229.

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Background:: The enzyme trans-enoyl-[acyl carrier protein] reductase (InhA) is a central protein for the development of antitubercular drugs. This enzyme is the target for the pro-drug isoniazid, which is catalyzed by the enzyme catalase-peroxidase (KatG) to become active. Objective:: Our goal here is to review the studies on InhA, starting with general aspects and focusing on the recent structural studies, with emphasis on the crystallographic structures of complexes involving InhA and inhibitors. Method:: We start with a literature review, and then we describe recent studies on InhA crystall

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45

Prasad, Mayuri S., Ritesh P. Bhole, Pramod B. Khedekar, and Rupesh V. Chikhale. "Mycobacterium enoyl acyl carrier protein reductase (InhA): A key target for antitubercular drug discovery." Bioorganic Chemistry 115 (October 2021): 105242. http://dx.doi.org/10.1016/j.bioorg.2021.105242.

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T Chhabria, Mahesh, Kailash B Parmar, and Pathik S Brahmkshatriya. "A Rational Approach to Identify Inhibitors of Mycobacterium tuberculosis Enoyl Acyl Carrier Protein Reductase." Current Pharmaceutical Design 19, no. 21 (2013): 3878–83. http://dx.doi.org/10.2174/1381612811319210012.

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Yao, Jiangwei, and Charles O. Rock. "Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics." Cold Spring Harbor Perspectives in Medicine 6, no. 3 (2016): a027045. http://dx.doi.org/10.1101/cshperspect.a027045.

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Park, Hee Soo, Yu Min Yoon, Sung Ji Jung, Cheol Min Kim, Jeong Mi Kim, and Jin-Hwan Kwak. "Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor." Journal of Antimicrobial Chemotherapy 60, no. 3 (2007): 568–74. http://dx.doi.org/10.1093/jac/dkm236.

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Rafi, Salma, Polina Novichenok, Subramaniapillai Kolappan, et al. "Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase fromEscherichia coli." Journal of Biological Chemistry 281, no. 51 (2006): 39285–93. http://dx.doi.org/10.1074/jbc.m608758200.

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Bi, H., L. Zhu, H. Wang, and J. E. Cronan. "Inefficient Translation Renders the Enterococcus faecalis fabK Enoyl-Acyl Carrier Protein Reductase Phenotypically Cryptic." Journal of Bacteriology 196, no. 1 (2013): 170–79. http://dx.doi.org/10.1128/jb.01148-13.

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