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1

Grossman, Charles M. "Enteric Coated Aspirin." American Journal of Medicine 120, no. 4 (2007): e9. http://dx.doi.org/10.1016/j.amjmed.2006.04.033.

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2

Behrend, Matthias, and Felix Braun. "Enteric-Coated Mycophenolate Sodium." Drugs 65, no. 8 (2005): 1037–50. http://dx.doi.org/10.2165/00003495-200565080-00001.

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3

Moreno, Santiago, Beatriz Hern??ndez, and Fernando Dronda. "Didanosine Enteric-Coated Capsule." Drugs 67, no. 10 (2007): 1441–62. http://dx.doi.org/10.2165/00003495-200767100-00006.

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4

Sanford, Mark, and Gillian M. Keating. "Enteric-Coated Mycophenolate Sodium." Drugs 68, no. 17 (2008): 2505–33. http://dx.doi.org/10.2165/0003495-200868170-00007.

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5

Gabardi, Steven, Jennifer L. Tran, and Michael R. Clarkson. "Enteric-Coated Mycophenolate Sodium." Annals of Pharmacotherapy 37, no. 11 (2003): 1685–93. http://dx.doi.org/10.1345/aph.1d063.

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OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of mycophenolate sodium. DATA SOURCES: Primary literature was obtained via a MEDLINE search (1966–June 2003). Abstracts were obtained from the manufacturer and included in the analysis. STUDY SELECTION AND DATA EXTRACTION: All studies and abstracts evaluating mycophenolate sodium in solid organ transplantation were considered for inclusion. English-language studies and abstracts were selected for inclusion, but were limited to those consisting of human subjects. DATA SYNTHESIS: Mycophenolate sodium, a mycophenolic ac
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6

&NA;. "Enteric-coated magnesium supplement." Journal of Cardiopulmonary Rehabilitation 9, no. 3 (1989): 127. http://dx.doi.org/10.1097/00008483-198903200-00005.

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7

Budde, Klemens, Michael Dürr, Lutz Liefeldt, Hans-Hellmut Neumayer, and Petra Glander. "Enteric-coated mycophenolate sodium." Expert Opinion on Drug Safety 9, no. 6 (2010): 981–94. http://dx.doi.org/10.1517/14740338.2010.513379.

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8

Sinthya, H. M.1 Panchami N. M.2 Chandana3 Firdos sultana*4 Uma maheswari5 Raziya begum6 Vasantha T. S.7. "Comparison Studies Of Enteric Coated And Uncoated Tablets." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 786–90. https://doi.org/10.5281/zenodo.10988185.

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Aspirin is belonging to the class of NSAID having analgesic, antipyretic, anti-inflammatory and antiplatelet activity at regular normal doses. At higher doses it causes gastrointestinal ulcers, stomach bleeding etc. This effect of aspirin can be minimized by preventing the drug exposure to the gastric region which is achieved by using enteric coating of the aspirin tablet. Clinicians recommend enteric-coated aspirin to decrease gastrointestinal bleeding in secondary prevention of coronary artery disease even though studies suggest platelet inhibition is decreased with enteric-coated vs uncoate
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9

&NA;. "Enteric-coated doxycycline improves gastrointestinal tolerability." Reactions Weekly &NA;, no. 583 (1996): 5. http://dx.doi.org/10.2165/00128415-199605830-00005.

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10

Pierce, Robert P., John Gazewood, and Robert L. Blake. "Salicylate poisoning from enteric-coated aspirin." Postgraduate Medicine 89, no. 5 (1991): 61–64. http://dx.doi.org/10.1080/00325481.1991.11700890.

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11

Grossman, C. M. "Enteric coated aspirin may reduce risk." BMJ 311, no. 7001 (1995): 391. http://dx.doi.org/10.1136/bmj.311.7001.391c.

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12

Zhang, W., C. Ding, and S. Zheng. "Enteric-coated mycophenolate sodium: an update." International Journal of Clinical Practice 68 (March 27, 2014): 1–3. http://dx.doi.org/10.1111/ijcp.12399.

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13

Gilbert, J., and J. M. Littlewood. "ENTERIC-COATED PREDNISOLONE IN CYSTIC FIBROSIS." Lancet 328, no. 8516 (1986): 1167–68. http://dx.doi.org/10.1016/s0140-6736(86)90582-9.

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14

Vyas, H., D. J. Matthew, and P. J. Milla. "A comparison of enteric coated microspheres with enteric coated tablet pancreatic enzyme preparations in cystic fibrosis." European Journal of Pediatrics 149, no. 4 (1990): 241–43. http://dx.doi.org/10.1007/bf02106281.

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15

Peters, I. O. M., A. Willemsen, J. J. de Bruyne, and R. C. Nap. "Aspirin Medication in Dogs." Veterinary and Comparative Orthopaedics and Traumatology 4, no. 03 (1991): 95–99. http://dx.doi.org/10.1055/s-0038-1633260.

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SummaryAspirin (acetylsalicylic acid; ASA) is widely used in both human and veterinary medicine. Therapeutic plasma salicylate concentrations (PSCs) can be reached using enteric-coated ASA tablets, but a delay in the initial rise and large fluctuations in the PSCs have been reported. From experiments described previously, the authors concluded that the large type enteric-coated ASA tablets were not suitable for use in beagle dogs.In the first experiment described here, these large type tablets were administered to large mongrel dogs. Although the mean PSC reached therapeutic levels after 44 h,
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16

Patel, Hetal, and Mukesh Gohel. "A Review on Enteric Coated Pellets Composed of Core Pellets Prepared by Extrusion-Spheronization." Recent Patents on Drug Delivery & Formulation 13, no. 2 (2019): 83–90. http://dx.doi.org/10.2174/1872211313666190212115139.

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Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibit less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-spheronization technique a
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17

Carter, Barry L., Jerold C. Woodhead, Katherine J. Cole, and Gary Milavetz. "Gastrointestinal Side Effects with Erythromycin Preparations." Drug Intelligence & Clinical Pharmacy 21, no. 9 (1987): 734–38. http://dx.doi.org/10.1177/106002808702100914.

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This study was designed to determine the incidence and severity of gastrointestinal (GI) side effects in patients taking erythromycin. More patients complained of GI side effects with the enteric-coated tablet (70.8 percent) than with the stearate (51.4 percent) or the ethylsuccinate (48.9 percent) salts. The enteric-coated tablet was associated with a higher incidence of individual adverse reactions; more patients discontinued it because of adverse GI effects. These data demonstrate a high incidence of GI side effects to erythromycin. Additionally, GI side-effect incidence appears to be highe
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18

Chapron, Dennis J., Lisa B. Korman, and William L. Barry. "Gastric Retention of Enteric-Coated Magnesium Chloride Tablets." Annals of Pharmacotherapy 28, no. 7-8 (1994): 874–77. http://dx.doi.org/10.1177/106002809402800710.

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OBJECTIVE: To describe a patient with gastric retention of enteric-coated magnesium chloride tablets. Potential drug and disease etiologies accounting for failure to empty this dosage form are discussed. DESIGN: Single case report. CASE SUMMARY: A seriously ill patient with metastatic small-cell lung cancer accumulated 21 enteric-coated magnesium chloride tablets in his stomach during a four-day administration period. The patient had gastroscopic evidence of mild pylorospasm and suspected gastric motor dysfunction. The latter may have been the result of several factors including concurrent use
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19

Lim, Dong-Jin. "3-O-Ethyl-L-Ascorbic Acid Doped Enteric-Coated Gelatin Capsules towards the Advanced Oral Curcumin Delivery for Cancers." Polymers 14, no. 11 (2022): 2207. http://dx.doi.org/10.3390/polym14112207.

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Among plant-derived polyphenols, curcumin has been recognized as a therapeutically potent nutrient presenting pleiotropic pharmacological effects on various cancers. However, the poor absorption and bioavailability of curcumin limit the use of this excellent naturally occurring polyphenol. 3-O-ethyl-L-ascorbic acid (EA) doped enteric-coated gelatin capsules were studied in the search for advanced oral curcumin delivery. The EA doped enteric-coated gelatin capsules were successfully created based on a developed inner dual enteric coating technique. When placed in four buffer solutions with diff
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20

Chono, Sumio, Megumi Matsui, and Katsuki Nakamura. "Effect of water temperature on a simple suspension method for lansoprazole orally disintegrating tablets." Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 15, no. 1 (2019): 4–9. http://dx.doi.org/10.1177/1741134319826399.

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In this study, we examined the physical properties, including disintegration, passage through a nasogastric administration tube, and acidoresistance, of one branded and five generic formulations of lansoprazole orally disintegrating (OD) tablets containing enteric-coated granules to examine the feasibility of a simple suspension method. The generic tablets immediately disintegrated in warm (55°C) and lukewarm water (35°C) and released the enteric-coated granules, which passed through an administration tube. Moreover, the released enteric-coated granules were stable under a simulated gastric ac
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21

B. H. Al-Khedairy, Eman. "In Vitro Release Study on Capsules and Tablets Containing Enteric - Coated Granules Prepared by Wet Granulation." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 15, no. 1 (2017): 49–52. http://dx.doi.org/10.31351/vol15iss1pp49-52.

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Wet granulation method was used instead of conventional pan coating or fluidized –bed coating technique to prepare enteric-coated diclofenac sodium granules, using ethanolic solution of EudragitTM L100 as coating, binding and granulating agent .Addition of PEG400 or di-n-butyl phthalate as a plasticizer was found to improve the enteric property of the coat.
 Part of the resulted granules was filled in hard gelatin capsules (size 0), while the other part was compressed into tablets with and without disintegrant.
 The release profile of these two dosage forms in 0.1N HCl (pH 1.2)for
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22

Jiang, Fang-Lin, Dong-Ho Jeong, Seon-Ho Eom, et al. "Effects of Enteric-Coated Formulation of Sodium Bicarbonate on Bicarbonate Absorption and Gastrointestinal Discomfort." Nutrients 16, no. 5 (2024): 744. http://dx.doi.org/10.3390/nu16050744.

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Sodium bicarbonate is used as an ergogenic supplement to enhance people’s performances in various exercises. This study aimed to evaluate the effects of intestinal delivery of sodium bicarbonate on bicarbonate absorption and associated side effects in an experimental human trial. After preparing and assessing enteric-coated and uncoated sodium bicarbonate tablet formulations, pharmacokinetic analysis and gastrointestinal symptom tests were performed after oral administration in the human body. The dose required to increase blood bicarbonate concentration over 5 mmol∙L−1 for the purpose of impr
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23

Guragain, Sanjeev, and Namrata Upadhayay. "Problems Associated with the Use of Enteric Coated Tablets, Extended Release Tablets and the Storage of Paediatric Antibiotics at Devdaha Municipality in Nepal." Medical Journal of Eastern Nepal 1, no. 02 (2022): 28–32. http://dx.doi.org/10.3126/mjen.v1i02.51160.

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Background Enteric coated tablets and extended release tablets are such kinds of tablets that should not be taken in crushed form. Pharmacists may advise to break or crush such tablets to manage the dose form that may lead therapeutic failure and increase the side effects of it. Further, they may not advise patients for the storage of paediatric antibiotics at 2-8° C. The first objective of our study is to find the knowledge among pharmacists about dispensing enteric coated and extended release tablets. The second objective is to explore the knowledge and practice of pharmacists about the stor
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24

Salvadori, Maurizio, and Elisabetta Bertoni. "Enteric-coated mycophenolate sodium: role in transplantation." Therapy 3, no. 2 (2006): 201–14. http://dx.doi.org/10.2217/14750708.3.2.201.

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25

Le, Xuan Truong, Hue Minh Nguyen, Ngoc Quynh Le, Thi Thu Loan Trinh, and VanThanh Tran. "Formulation of enteric coated microspheres containing pantoprazole." Ministry of Science and Technology, Vietnam 63, no. 3 (2021): 56–62. http://dx.doi.org/10.31276/vjste.63(3).56-62.

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Pantoprazole is a first-line proton pump inhibitor drug for the treatment of gastric acid secretion disorders that is known to have minimal side effects and drug interactions. To improve its stability in gastric acid, delayed-release microspheres containing pantoprazole was prepared by emulsification-solvent evaporation using a polymer-containing mixture of hydroxypropyl cellulose (HPC) and ethyl cellulose (EC), which was then coated by alginate and EudragitL100. The morphological characteristics of the microspheres were examined by SEM, the particle size distribution inferred by laser diffra
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26

&NA;. "Fewer GI lesions with enteric-coated piroxicam." Inpharma Weekly &NA;, no. 876 (1993): 22. http://dx.doi.org/10.2165/00128413-199308760-00045.

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27

Ingle, Gordon R., and Tariq Shah. "Enteric-coated mycophenolate sodium for transplant immunosuppression." American Journal of Health-System Pharmacy 62, no. 21 (2005): 2252–59. http://dx.doi.org/10.2146/ajhp040380.

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28

&NA;. "Enteric-coated mycophenolate sodium soothes GI symptoms." Inpharma Weekly &NA;, no. 1514 (2005): 5. http://dx.doi.org/10.2165/00128413-200515140-00011.

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29

Dedík, L., and M. Durosová. "Modeling drug absorption from enteric-coated granules." Methods and Findings in Experimental and Clinical Pharmacology 23, no. 5 (2001): 213. http://dx.doi.org/10.1358/mf.2001.23.5.662114.

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30

Ibrahim, Sarah A., and Luigi Martini. "Automated Dissolution for Enteric-Coated Aspirin Tablets." Journal of Laboratory Automation 19, no. 4 (2014): 375–80. http://dx.doi.org/10.1177/2211068213520401.

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31

Williams, J., A. MacDonald, P. H. Weller, J. Fields, and H. Pandov. "Two enteric coated microspheres in cystic fibrosis." Archives of Disease in Childhood 65, no. 6 (1990): 594–97. http://dx.doi.org/10.1136/adc.65.6.594.

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32

Bruce, L. Diane, Hans-Ulrich Petereit, Thomas Beckert, and James W. McGinity. "Properties of enteric coated sodium valproate pellets." International Journal of Pharmaceutics 264, no. 1-2 (2003): 85–96. http://dx.doi.org/10.1016/s0378-5173(03)00392-2.

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33

Wortzman, David J., and Anton Grunfeld. "Delayed absorption following enteric-coated aspirin overdose." Annals of Emergency Medicine 16, no. 4 (1987): 434–36. http://dx.doi.org/10.1016/s0196-0644(87)80366-9.

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34

Green, Rob, Wes Palatnick, and Milton Tenenbein. "Enteric-coated salicylate ingestion and gastric lavage." CJEM 3, no. 03 (2001): 176. http://dx.doi.org/10.1017/s1481803500005443.

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35

Wassif, W., P. Pitt, F. Li, et al. "P14. Enteric coated sodium fluoride for osteoporosis." Bone 13, no. 1 (1992): 111. http://dx.doi.org/10.1016/8756-3282(92)90417-u.

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36

&NA;. "Enteric-coated mycophenolate sodium for heart transplant." Inpharma Weekly &NA;, no. 1556 (2006): 12. http://dx.doi.org/10.2165/00128413-200615560-00029.

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37

Matsukawa, Y., and I. Hayashi. "Prolonged gastric stasis of enteric-coated granules." Case Reports 2009, jun01 1 (2009): bcr0820080622. http://dx.doi.org/10.1136/bcr.08.2008.0622.

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38

Klank, Sabrina, Christina van Stein, Marianne Grüneberg, et al. "Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients." Pharmaceutics 15, no. 7 (2023): 1851. http://dx.doi.org/10.3390/pharmaceutics15071851.

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Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the organelle. The need for frequent dosing every 6 h and the high prevalence of gastrointestinal side effects lead to poor therapy adherence. The purpose of our study was to improve cysteamine treatment by comparing the efficacy of two cysteamine formulas. This is highly relevant for the long-term outcome of cystinosis patients. The cystine and c
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39

Stead, R. J., I. Skypala, M. E. Hodson, and J. C. Batten. "Enteric coated microspheres of pancreatin in the treatment of cystic fibrosis: comparison with a standard enteric coated preparation." Thorax 42, no. 7 (1987): 533–37. http://dx.doi.org/10.1136/thx.42.7.533.

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40

Jitendra, Sahu Jatin Kumar Sinha Bhumika Sahu Harish Sharma Gyanesh Kumar Sahu. "Development and Characterization of Enteric Coated Diclofenac Sodium Tablet." Int. J. in Pharm. Sci. 1, no. 3 (2023): 210–18. https://doi.org/10.5281/zenodo.7921095.

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Tablets of the drug diclofenac sodium with an enteric coating are used to treat fever, discomfort, and inflammation. The pills are made to withstand the stomach's acidic environment while dissolving in the small intestine's alkaline environment. With this delayed release formulation, there is a lower chance of experiencing gastrointestinal adverse effects while also extending the duration of medication absorption and increasing medicinal efficacy. Enteric coated tablets are solid unit dose forms for oral administration that bypass the stomach and transport the medication straight to th
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41

Rathore, Surya Bhan Singh, Anshu Sharma, Ayush Garg, and Dharmendra Singh Sisodiya. "Formulation and evaluation of enteric coated tablet of Ilaprazole." International Current Pharmaceutical Journal 2, no. 7 (2013): 126–30. http://dx.doi.org/10.3329/icpj.v2i7.15156.

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The present study was an attempt to formulate and evaluate enteric coated tablets for Ilaprazole to reduce the gastrointestinal tract side effects. Four formulations of core tablets were prepared and one who shows rapid disintegration (near around three minutes) was selected for enteric coating. Ilaprazole which have an irritant effect on the stomach can be coated with a substance that will only dissolve in the small intestine. Enteric coat was optimized using two different polymers such as HPMCP 50 and Eudragit L 100 in different concentrations. The prepared tablets were evaluated in terms of
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42

Deepika., B* SK China Bikari Naga Raju Kandukoori A. Thanga Thirupathi K.Sujatha. "DEVELOPMENT AND EVALUATION OF ENTERIC COATED OMEPRAZOLE PELLETS 22.5% W/W." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6191–97. https://doi.org/10.5281/zenodo.1307192.

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<em>The objective of the present study is to formulate and evaluate enteric coated delayed release pellets of Omeprazole. The formulations of Omeprazole delayed release pellets of were developed by enteric film coating process varying the compositions of drug loading, barrier coating and enteric coating. HPMC E5 was used as enteric polymer. The process variables were standardized and the different batches prepared were evaluated for assay/drug content, water content, acid resistance and dissolution rate. The drug dissolution profiles of Omeprazole delayed release formulations developed were co
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43

Deepika., B* SK China Bikari Naga Raju Kandukoori A. Thanga Thirupathi K.Sujatha. "DEVELOPMENT AND EVALUATION OF ENTERIC COATED OMEPRAZOLE PELLETS 22.5% W/W." Indo American Journal of Pharmaceutical Sciences 05, no. 07 (2018): 6229–35. https://doi.org/10.5281/zenodo.1307374.

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<em>The objective of the present study is to formulate and evaluate enteric coated delayed release pellets of Omeprazole. The formulations of Omeprazole delayed release pellets of were developed by enteric film coating process varying the compositions of drug loading, barrier coating and enteric coating. HPMC E5 was used as enteric polymer. The process variables were standardized and the different batches prepared were evaluated for assay/drug content, water content, acid resistance and dissolution rate. The drug dissolution profiles of Omeprazole delayed release formulations developed were co
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44

Mehetre, Gautam D., Rameshwar S. Cheke, and Vinayak N. Shrikhande. "Formulation and In-Vitro Evaluation of Enteric Coated Tablet Incorporating Rabeprazole." Journal of Drug Delivery and Therapeutics 10, no. 2-s (2020): 50–57. http://dx.doi.org/10.22270/jddt.v10i2-s.3953.

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The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achie
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45

Chen, Xue, Feng Gao, and Jie Zhang. "Screening for Gastric and Small Intestinal Mucosal Injury with Magnetically Controlled Capsule Endoscopy in Asymptomatic Patients Taking Enteric-Coated Aspirin." Gastroenterology Research and Practice 2018 (November 15, 2018): 1–6. http://dx.doi.org/10.1155/2018/2524698.

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Objective. To investigate gastric and small intestinal mucosal injury in asymptomatic patients taking enteric-coated aspirin using magnetically controlled capsule endoscopy. Methods. Patients taking enteric-coated aspirin (aspirin group) and healthy controls (control group) were recruited from Beijing Anzhen Hospital, Capital Medical University, between September 2017 and May 2018, and undertook magnetically controlled capsule endoscopy. Results. Twenty-six subjects were recruited to the aspirin group and twenty-six to the control group; the median Gastrointestinal Symptom Rating Scale scores
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46

Bushra, Rabia, Muhammad Harris Shoaib, Nousheen Aslam, Zafar Alam Mehmood, and Durriya Hashmat. "Enteric coating of ibuprofen tablets (200 mg) using an aqueous dispersion system." Brazilian Journal of Pharmaceutical Sciences 46, no. 1 (2010): 99–107. http://dx.doi.org/10.1590/s1984-82502010000100011.

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Ibuprofen is a propionic acid derivative that belongs to the class NSAIDs. Major adverse reactions associated with Ibuprofen are related to GIT and include peptic and mucosal ulcers, dyspepsia, severe gastric pain and bleeding, that results in excessive treatment failure. The goal of this study was to develop enteric coated ibuprofen tablets in order to avoid gastric mucosal irritation, diffusion of drug across mucosal lining and to let active ingredient be absorbed easily in small intestine. The formulation was developed and manufactured through the direct compression process, the simplest, e
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47

Kalnins, Daina, Lynda Ellis, Mary Corey, et al. "Enteric-Coated Pancreatic Enzyme with Bicarbonate Is Equal to Standard Enteric-Coated Enzyme in Treating Malabsorption in Cystic Fibrosis." Journal of Pediatric Gastroenterology and Nutrition 42, no. 3 (2006): 256–61. http://dx.doi.org/10.1097/01.mpg.0000189356.93784.01.

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48

Wang-Smith, Laurene, John Fort, Ying Zhang, and Mark Sostek. "Pharmacokinetics and Relative Bioavailability of a Fixed-Dose Combination of Enteric-Coated Naproxen and Non-Enteric-Coated Esomeprazole Magnesium." Journal of Clinical Pharmacology 52, no. 5 (2012): 670–80. http://dx.doi.org/10.1177/0091270011405500.

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49

Schmidt, Peter C., and Frank Niemann. "The MiniWiD-COATER: II. Comparison of acid resistance of enteric-coated bisacodyl pellets coated with different polymers." Drug Development and Industrial Pharmacy 18, no. 18 (1992): 1969–79. http://dx.doi.org/10.3109/03639049209052412.

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50

Surisetty, Sridevi* D. Vinay Kumar SNVL Sirisha. "Formulation And Evaluation of Erythromycin Delayed Release Tablets." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 152–61. https://doi.org/10.5281/zenodo.8330907.

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The present study is to formulate and&nbsp; evaluate Erythromycin enteric coated tablets prepared by wet granulation method by using Povidone k30 as polymer, Tricetin as plasticizer ,titanium dioxide as opacifer ,aqueous coating Eudragit 100-55 as coating agent and opadry red as coloring agent .The physico - chemical incompatibity was studied by using Hplc and physical parameters of prepared enteric coated tablets were evaluated as pharmacopeia standards .The dissolution studies of prepared enteric coated tablets was evaluated as pharmacopeia standards .The dissolution studies were performed b
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