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Journal articles on the topic 'Enteric pathogen'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kempf, Florent, Roberto La La Ragione, Barbara Chirullo, Catherine Schouler, and Philippe Velge. "Super Shedding in Enteric Pathogens: A Review." Microorganisms 10, no. 11 (2022): 2101. http://dx.doi.org/10.3390/microorganisms10112101.

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Super shedding occurs when a small number of individuals from a given host population shed high levels of a pathogen. Beyond this general definition, various interpretations of the shedding patterns have been proposed to identify super shedders, leading to the description of the super shedding phenomenon in a wide range of pathogens, in particular enteric pathogens, which are of considerable interest. Several underlying mechanisms may explain this observation, including factors related to the environment, the gut microbiota, the pathogen itself (i.e., genetic polymorphism), and the host (inclu

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Tsai, Kevin, Sheillah Simiyu, Jane Mumma, et al. "Enteric Pathogen Diversity in Infant Foods in Low-Income Neighborhoods of Kisumu, Kenya." International Journal of Environmental Research and Public Health 16, no. 3 (2019): 506. http://dx.doi.org/10.3390/ijerph16030506.

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Pediatric diarrheal disease remains the second most common cause of preventable illness and death among children under the age of five, especially in low and middle-income countries (LMICs). However, there is limited information regarding the role of food in pathogen transmission in LMICs. For this study, we examined the frequency of enteric pathogen occurrence and co-occurrence in 127 infant weaning foods in Kisumu, Kenya, using a multi-pathogen PCR diagnostic tool, and assessed household food hygiene risk factors for contamination. Bacterial, viral, and protozoan enteric pathogen DNA and RNA

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Gutema, Fanta D., Bonphace Okoth, John Agira, et al. "Spatial–Temporal Patterns in the Enteric Pathogen Contamination of Soil in the Public Environments of Low- and Middle-Income Neighborhoods in Nairobi, Kenya." International Journal of Environmental Research and Public Health 21, no. 10 (2024): 1351. http://dx.doi.org/10.3390/ijerph21101351.

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Public spaces in countries with limited societal development can be contaminated with feces containing pathogenic microbes from animals and people. Data on contamination levels, spatial distribution, and the diversity of enteric pathogens in the public settings of low- and middle-income neighborhoods are crucial for devising strategies that minimize the enteric infection burden. The objective of this study was to compare spatial–temporal differences in the detection rate and diversity of enteric pathogens in the public spaces of low- and middle-income neighborhoods of Nairobi, Kenya. TaqMan ar

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Gorvel, Jean Pierre, Edgardo Moreno, and Ignacio Moriyón. "Is Brucella an enteric pathogen?" Nature Reviews Microbiology 7, no. 3 (2009): 250. http://dx.doi.org/10.1038/nrmicro2012-c1.

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Altwegg, M. "Aeromonas caviae: An enteric pathogen?" Infection 13, no. 5 (1985): 228–30. http://dx.doi.org/10.1007/bf01667217.

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McNeil, Candice J., Robert D. Kirkcaldy, and Kimberly Workowski. "Enteric Infections in Men Who Have Sex With Men." Clinical Infectious Diseases 74, Supplement_2 (2022): S169—S178. http://dx.doi.org/10.1093/cid/ciac061.

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Abstract Background Enteric pathogens are often associated with exposure to food, water, animals, and feces from infected individuals. However, in sexual networks of men who have sex with men (MSM), transmission of enteric pathogens may occur during direct or indirect oral–anal contact. Methods We performed a scoping review of the literature for studies prior to July 2019 with key terms for gastrointestinal syndromes (“proctitis,” “enteritis,” “proctocolitis”), enteric pathogens or sexually transmitted infections (STIs), and outbreaks using multiple electronic databases. Results We identified

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Potgieter, Natasha, Lee Heine, Jean Pierre Kabue Ngandu, et al. "High Burden of Co-Infection with Multiple Enteric Pathogens in Children Suffering with Diarrhoea from Rural and Peri-Urban Communities in South Africa." Pathogens 12, no. 2 (2023): 315. http://dx.doi.org/10.3390/pathogens12020315.

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Infectious diarrhoea contributes to high morbidity and mortality in young children from sub-Saharan Africa. The aim of this study was to assess the prevalence of single and multiple diarrhoeal-causing pathogen combinations in children suffering from diarrhoea from rural and peri-urban communities in South Africa. A total of 275 diarrhoea stool specimens were collected between 2014 and 2016 from Hospitals and Primary Health Care clinics. The BioFire® FilmArray® Gastrointestinal panel was used to simultaneously detect 22 diarrhoea pathogens (viruses, bacteria, parasites) known to cause diarrhoea

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Gourabathini, Poornima, Maria T. Brandl, Katherine S. Redding, John H. Gunderson, and Sharon G. Berk. "Interactions between Food-Borne Pathogens and Protozoa Isolated from Lettuce and Spinach." Applied and Environmental Microbiology 74, no. 8 (2008): 2518–25. http://dx.doi.org/10.1128/aem.02709-07.

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ABSTRACT The survival of Salmonella enterica was recently shown to increase when the bacteria were sequestered in expelled food vacuoles (vesicles) of Tetrahymena. Because fresh produce is increasingly linked to outbreaks of enteric illness, the present investigation aimed to determine the prevalence of protozoa on spinach and lettuce and to examine their interactions with S. enterica, Escherichia coli O157:H7, and Listeria monocytogenes. Glaucoma sp., Colpoda steinii, and Acanthamoeba palestinensis were cultured from store-bought spinach and lettuce and used in our study. A strain of Tetrahym

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Leu-Burke, Grace, Robert Beacham, and Courtney Bennetts. "Discovery of Enteric Pathogens in the Alaskan Subsistence Diet." American Journal of Clinical Pathology 152, Supplement_1 (2019): S129. http://dx.doi.org/10.1093/ajcp/aqz125.003.

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Abstract Objectives Transmission of enteric pathogens from food ingestion is an ongoing public health concern, with commensal bacteria in ruminant animal species causing human disease. Enteric pathogens Salmonella, Shigella, and Shiga toxin producing Escherichia coli (STEC) have been isolated from domesticated animals. However, the Alaskan subsistence diet relies on wild game, such as reindeer, caribou, and moose for their food supply. Research concerning enteric pathogens in wildlife has not established. Therefore, we conducted a pilot survey on moose and reindeer to determine potential enter

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Barker, Troy, Drew Capone, Heather K. Amato, et al. "Public toilets have reduced enteric pathogen hazards in San Francisco." PLOS Water 2, no. 8 (2023): e0000152. http://dx.doi.org/10.1371/journal.pwat.0000152.

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Uncontained fecal wastes in cities may present exposure risks to the public. We collected discarded feces from public spaces in San Francisco, CA for analysis by RT-qPCR for a range of enteric pathogens. Out of 59 samples, we found 12 (20%) were of human origin and 47 (80%) were non-human; 30 of 59 stools were positive for ≥1 of the 35 pathogens assessed, including pathogenic E. coli, Shigella, norovirus, Cryptosporidium, and Trichuris. Using quantitative enteric pathogen estimates and data on observed fecal waste from a public reporting system, we modeled pathogens removed from the environmen

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Cerdán-Alduán, Michelle, Josune Salvador-Erro, Ana Villegas-Remírez, et al. "Yeast Strains as Probiotic and Postbiotic Agents for the Agglutination of Enteric Pathogens: A Preventive Approach." Pathogens 14, no. 2 (2025): 113. https://doi.org/10.3390/pathogens14020113.

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This study evaluates the potential of various yeast strains as probiotic and postbiotic agents for agglutinating enteric pathogens, offering a preventive approach to gastrointestinal infections. Different yeast species were tested in vitro against a range of pathogenic bacteria, including enterotoxigenic Escherichia coli ETEC, Shigella flexneri, Salmonella enterica serovar Typhimurium, and Salmonella enterica serovar Enteritidis, to assess their capacity for pathogen agglutination. Additionally, inactivated yeasts were obtained using a novel chemical treatment and employed to explore their eff

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Ricci de Azevedo, Rafael, and Sivapriya Kailasan Vanaja. "Enteric pathogen targeting of the inflammasome pathway." Journal of Immunology 212, no. 1_Supplement (2024): 0485_5182. http://dx.doi.org/10.4049/jimmunol.212.supp.0485.5182.

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Abstract Pattern recognition receptors-based sensing of microbial products and activities to mount an effective antibacterial defense is an evolutionarily conserved immune strategy. Cytosolic LPS sensing by caspase-11 or -4 and the ensuing noncanonical inflammasome-mediated IL-1 and cell death responses play a central role in the clearance of bacterial pathogens. In response to this selection pressure from the host it is natural that pathogens have developed strategies to actively antagonize or evade inflammasome responses. However, the mechanisms by which bacterial pathogens subvert the nonca

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Quevedo, Sara M., María D. Martín, and Aurelio C. Velasco. "Moellerella wisconsensis: A hidden enteric pathogen?" Clinical Microbiology Newsletter 28, no. 18 (2006): 142–43. http://dx.doi.org/10.1016/j.clinmicnews.2006.09.002.

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14

Barman, Melissa, David Unold, Kathleen Shifley, et al. "Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract." Infection and Immunity 76, no. 3 (2007): 907–15. http://dx.doi.org/10.1128/iai.01432-07.

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ABSTRACT The commensal microbiota protects the murine host from enteric pathogens. Nevertheless, specific pathogens are able to colonize the intestinal tract and invade, despite the presence of an intact biota. Possibly, effective pathogens disrupt the indigenous microbiota, either directly through pathogen-commensal interaction, indirectly via the host mucosal immune response to the pathogen, or by a combination of these factors. This study investigates the effect of peroral Salmonella enterica serovar Typhimurium infection on the intestinal microbiota. Since the majority of the intestinal mi

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Luppi, Andrea, Giulia D’Annunzio, Camilla Torreggiani, and Paolo Martelli. "Diagnostic Approach to Enteric Disorders in Pigs." Animals 13, no. 3 (2023): 338. http://dx.doi.org/10.3390/ani13030338.

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The diagnosis of enteric disorders in pigs is extremely challenging, at any age. Outbreaks of enteric disease in pigs are frequently multifactorial and multiple microorganisms can co-exist and interact. Furthermore, several pathogens, such as Clostridium perfrigens type A, Rotavirus and Lawsonia intracellularis, may be present in the gut in the absence of clinical signs. Thus, diagnosis must be based on a differential approach in order to develop a tailored control strategy, considering that treatment and control programs for enteric diseases are pathogen-specific. Correct sampling for laborat

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Cribb, Danielle M., Nevio Sarmento, Almerio Moniz, et al. "A pilot study using hospital surveillance and a birth cohort to investigate enteric pathogens and malnutrition in children, Dili, Timor-Leste." PLOS ONE 19, no. 2 (2024): e0296774. http://dx.doi.org/10.1371/journal.pone.0296774.

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In low-to-middle-income countries (LMICs), enteric pathogens contribute to child malnutrition, affecting nutrient absorption, inducing inflammation, and causing diarrhoea. This is a substantial problem in LMICs due to high disease burden, poor sanitation and nutritional status, and the cyclical nature of pathogen infection and malnutrition. This relationship remains understudied in Timor-Leste. In our pilot study of enteric pathogens and malnutrition in Dili, Timor-Leste (July 2019–October 2020), we recruited 60 infants in a birth cohort from Hospital Nacional Guido Valadares (HNGV) with up to

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Marcenac, Perrine, Awa Traoré, Sunkyung Kim, et al. "Giardia Detection and Codetection With Other Enteric Pathogens in Young Children in the Vaccine Impact on Diarrhea in Africa (VIDA) Case-Control Study: 2015–2018." Clinical Infectious Diseases 76, Supplement_1 (2023): S106—S113. http://dx.doi.org/10.1093/cid/ciac940.

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Abstract Background Giardia has been associated with reduced risk of diarrhea in children in low-resource settings, but the mechanism underlying this association is unknown. To assess whether Giardia may shape colonization or infection with other enteric pathogens and impact associations with diarrhea, we examined Giardia and enteric pathogen codetection among children &lt;5 years old in Kenya, The Gambia, and Mali as part of the Vaccine Impact on Diarrhea in Africa study. Methods We tested for Giardia and other enteric pathogens using enzyme-linked immunosorbent assays and real-time polym

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Gül, Ersin, Ursina Enz, Luca Maurer, et al. "Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection." PLOS Pathogens 19, no. 6 (2023): e1011235. http://dx.doi.org/10.1371/journal.ppat.1011235.

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Recruitment of neutrophils into and across the gut mucosa is a cardinal feature of intestinal inflammation in response to enteric infections. Previous work using the model pathogen Salmonella enterica serovar Typhimurium (S.Tm) established that invasion of intestinal epithelial cells by S.Tm leads to recruitment of neutrophils into the gut lumen, where they can reduce pathogen loads transiently. Notably, a fraction of the pathogen population can survive this defense, re-grow to high density, and continue triggering enteropathy. However, the functions of intraluminal neutrophils in the defense

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Wang, Xixi, Chen Chen, Yang Yang, et al. "Proteome-Based Serotyping of the Food-Borne Pathogens Salmonella Enterica by Label-Free Mass Spectrometry." Molecules 27, no. 14 (2022): 4334. http://dx.doi.org/10.3390/molecules27144334.

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Food-borne diseases caused by Salmonella enterica of 2500 serovars represent a serious public health problem worldwide. A quick identification for the pathogen serovars is critical for controlling food pollution and disease spreading. Here, we applied a mass spectrum-based proteomic profiling for identifying five epidemiologically important Salmonella enterica subsp. enterica serovars (Enteritidis, Typhimurium, London, Rissen and Derby) in China. By label-free analysis, the 53 most variable serovar-related peptides, which were almost all enzymes related to nucleoside phosphate and energy metab

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Becker, Daniel J., Claire S. Teitelbaum, Maureen H. Murray, et al. "Assessing the contributions of intraspecific and environmental sources of infection in urban wildlife: Salmonella enterica and white ibis as a case study." Journal of The Royal Society Interface 15, no. 149 (2018): 20180654. http://dx.doi.org/10.1098/rsif.2018.0654.

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Conversion of natural habitats into urban landscapes can expose wildlife to novel pathogens and alter pathogen transmission pathways. Because transmission is difficult to quantify for many wildlife pathogens, mathematical models paired with field observations can help select among competing transmission pathways that might operate in urban landscapes. Here we develop a mathematical model for the enteric bacteria Salmonella enterica in urban-foraging white ibis ( Eudocimus albus ) in south Florida as a case study to determine (i) the relative importance of contact-based versus environmental tra

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Yan, Quanhui, Xiaodi Liu, Yawei Sun, et al. "Swine Enteric Coronavirus: Diverse Pathogen–Host Interactions." International Journal of Molecular Sciences 23, no. 7 (2022): 3953. http://dx.doi.org/10.3390/ijms23073953.

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Swine enteric coronavirus (SeCoV) causes acute gastroenteritis and high mortality in newborn piglets. Since the last century, porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) have swept farms all over the world and caused substantial economic losses. In recent years, porcine delta coronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV) have been emerging SeCoVs. Some of them even spread across species, which made the epidemic situation of SeCoV more complex and changeable. Recent studies have begun to reveal the complex SeCoV–ho

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Kailasan, Shweta, Sujata Halder, Brittney Gurda, et al. "Structure of an Enteric Pathogen, Bovine Parvovirus." Journal of Virology 89, no. 5 (2014): 2603–14. http://dx.doi.org/10.1128/jvi.03157-14.

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ABSTRACTBovine parvovirus (BPV), the causative agent of respiratory and gastrointestinal disease in cows, is the type member of theBocaparvovirusgenus of theParvoviridaefamily. Toward efforts to obtain a template for the development of vaccines and small-molecule inhibitors for this pathogen, the structure of the BPV capsid, assembled from the major capsid viral protein 2 (VP2), was determined using X-ray crystallography as well as cryo-electron microscopy and three-dimensional image reconstruction (cryo-reconstruction) to 3.2- and 8.8-Å resolutions, respectively. The VP2 region ordered in the

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Decaro, Nicola, and Canio Buonavoglia. "Canine Coronavirus: Not Only an Enteric Pathogen." Veterinary Clinics of North America: Small Animal Practice 41, no. 6 (2011): 1121–32. http://dx.doi.org/10.1016/j.cvsm.2011.07.005.

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Huang, David B., Pablo C. Okhuysen, Zhi-Dong Jiang, and Herbert L. DuPont. "Enteroaggregative Escherichia coli: An Emerging Enteric Pathogen." American Journal of Gastroenterology 99, no. 2 (2004): 383–89. http://dx.doi.org/10.1111/j.1572-0241.2004.04041.x.

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BELLET, JULIE, BRUCE KLEIN, MICHAEL ALTIERI, and DANIEL OCHSENSCHLAGER. "Vibrio fluvialis, an unusual pediatric enteric pathogen." Pediatric Emergency Care 5, no. 1 (1989): 27–28. http://dx.doi.org/10.1097/00006565-198903000-00008.

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Axelrad, J., A. Hine, J. Devlin, P. Loke, and K. Cadwell. "P832 Gastrointestinal infections are associated with unique gut microbiome signatures in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S644—S645. http://dx.doi.org/10.1093/ecco-jcc/jjz203.960.

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Abstract Background Stool PCR pathogen panel assays have implicated enteric infection in nearly 30% of inflammatory bowel disease (IBD) flares, most commonly with Clostridioides difficile, Escherichia coli, and norovirus. Many questions remain about the interpretation of a positive stool PCR result, and the similar presentations of infection and flare present a clinical challenge. We aimed to characterise the gut microbiome during an infection with C. difficile, E. coli, or norovirus in patients with and without IBD to microbially differentiate patients with an enteric infection, flare of IBD,

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Blais, Mylene, Michael Bouchard, Ckaude Asselin, and Martin Lessard. "The specific transcriptomic response of porcine intestinal epithelial cells to Escherichia coli and Salmonella enterica Typhimurium infections is modulated by bovine colostrum fractions." Journal of Immunology 204, no. 1_Supplement (2020): 79.9. http://dx.doi.org/10.4049/jimmunol.204.supp.79.9.

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Abstract Enterotoxigenic Escherichiacoli (ETEC) and Salmonella enterica Typhimurium are both enteric pathogens, but the mechanisms by which they infect intestinal epithelium are different. Recently, we observed that bovine colostrum (BC) increases protection against enteric infections in weaned piglets. In this study, we described the transcriptomic response of porcine intestinal epithelial cells IPEC-J2 infected by each pathogens, and we measured the specific effect of defatted BC, as well as bovine serocolostrum and casein fractions (SC and CAS respectively) on IPEC-J2 transcriptomic respons

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Sistrunk, Jeticia R., Kourtney P. Nickerson, Rachael B. Chanin, David A. Rasko, and Christina S. Faherty. "Survival of the Fittest: How Bacterial Pathogens Utilize Bile To Enhance Infection." Clinical Microbiology Reviews 29, no. 4 (2016): 819–36. http://dx.doi.org/10.1128/cmr.00031-16.

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SUMMARYBacterial pathogens have coevolved with humans in order to efficiently infect, replicate within, and be transmitted to new hosts to ensure survival and a continual infection cycle. For enteric pathogens, the ability to adapt to numerous host factors under the harsh conditions of the gastrointestinal tract is critical for establishing infection. One such host factor readily encountered by enteric bacteria is bile, an innately antimicrobial detergent-like compound essential for digestion and nutrient absorption. Not only have enteric pathogens evolved to resist the bactericidal conditions

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Le Bourhis, Lionel, Joao Gamelas Magalhaes, Thirumahal Selvanantham, et al. "Role of Nod1 in Mucosal Dendritic Cells during Salmonella Pathogenicity Island 1-Independent Salmonella enterica Serovar Typhimurium Infection." Infection and Immunity 77, no. 10 (2009): 4480–86. http://dx.doi.org/10.1128/iai.00519-09.

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ABSTRACT Recent advances in immunology have highlighted the critical function of pattern-recognition molecules (PRMs) in generating the innate immune response to effectively target pathogens. Nod1 and Nod2 are intracellular PRMs that detect peptidoglycan motifs from the cell walls of bacteria once they gain access to the cytosol. Salmonella enterica serovar Typhimurium is an enteric intracellular pathogen that causes a severe disease in the mouse model. This pathogen resides within vacuoles inside the cell, but the question of whether cytosolic PRMs such as Nod1 and Nod2 could have an impact o

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Colston, Josh M., Abu S. G. Faruque, M. Jahangir Hossain, et al. "Associations between Household-Level Exposures and All-Cause Diarrhea and Pathogen-Specific Enteric Infections in Children Enrolled in Five Sentinel Surveillance Studies." International Journal of Environmental Research and Public Health 17, no. 21 (2020): 8078. http://dx.doi.org/10.3390/ijerph17218078.

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Diarrheal disease remains a major cause of childhood mortality and morbidity causing poor health and economic outcomes. In low-resource settings, young children are exposed to numerous risk factors for enteric pathogen transmission within their dwellings, though the relative importance of different transmission pathways varies by pathogen species. The objective of this analysis was to model associations between five household-level risk factors—water, sanitation, flooring, caregiver education, and crowding—and infection status for endemic enteric pathogens in children in five surveillance stud

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Berendes, David M., Richard Omore, Graeme Prentice-Mott, et al. "Exploring Survey-Based Water, Sanitation, and Animal Associations With Enteric Pathogen Carriage: Comparing Results in a Cohort of Cases With Moderate-to-Severe Diarrhea to Those in Controls in the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015–2018." Clinical Infectious Diseases 76, Supplement_1 (2023): S140—S152. http://dx.doi.org/10.1093/cid/ciac918.

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Abstract Background The magnitude of pediatric enteric pathogen exposures in low-income settings necessitates substantive water and sanitation interventions, including animal feces management. We assessed associations between pediatric enteric pathogen detection and survey-based water, sanitation, and animal characteristics within the Vaccine Impact on Diarrhea in Africa case-control study. Methods In The Gambia, Kenya, and Mali, we assessed enteric pathogens in stool of children aged &lt;5 years with moderate-to-severe diarrhea and their matched controls (diarrhea-free in prior 7 days) vi

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Sidhu, Jatinder PS, and Simon G. Toze. "Pathogen survival in recycled water." Microbiology Australia 30, no. 1 (2009): 5. http://dx.doi.org/10.1071/ma09005.

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Pathogen survival in recycled water Water shortages affect more than 2 billion people worldwide in over 40 countries, with 1.1 billion people living without sufficient drinking water. Captured stormwater and treated wastewater can be used for supplementing non-potable water supplies. However presence of enteric pathogens in the reclaimed water can lead to potential health hazards.

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Nandi, Ipsita, and Benjamin Aroeti. "Mitogen-Activated Protein Kinases (MAPKs) and Enteric Bacterial Pathogens: A Complex Interplay." International Journal of Molecular Sciences 24, no. 15 (2023): 11905. http://dx.doi.org/10.3390/ijms241511905.

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Diverse extracellular and intracellular cues activate mammalian mitogen-activated protein kinases (MAPKs). Canonically, the activation starts at cell surface receptors and continues via intracellular MAPK components, acting in the host cell nucleus as activators of transcriptional programs to regulate various cellular activities, including proinflammatory responses against bacterial pathogens. For instance, binding host pattern recognition receptors (PRRs) on the surface of intestinal epithelial cells to bacterial pathogen external components trigger the MAPK/NF-κB signaling cascade, eliciting

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Kunte, D. P., T. Y. Yeole, and D. R. Ranade. "Two-stage anaerobic digestion process for complete inactivation of enteric bacterial pathogens in human night soil." Water Science and Technology 50, no. 6 (2004): 103–8. http://dx.doi.org/10.2166/wst.2004.0365.

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Anaerobic digestion offers a good alternative for human waste treatment. However, the fate of enteric bacterial pathogens present in human night soil (HNS) remains a major concern for hygienic safety of the process. A two-stage anaerobic digestion process, consisting of separate acidogenic and methanogenic digesters, was designed and its efficacy in the inactivation of Salmonella typhi was compared to a single-stage digestion process. In a single-stage digestion, complete pathogen inactivation was achieved only in the digesters with high levels of volatile fatty acids (VFA ≅18,000 mg/l) and ac

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El-Mohammady, Hanan, Adel Mansour, Hind I. Shaheen, et al. "Increase in the detection rate of viral and parasitic enteric pathogens among Egyptian children with acute diarrhea." Journal of Infection in Developing Countries 6, no. 11 (2012): 774–81. http://dx.doi.org/10.3855/jidc.2349.

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Introduction: Acute diarrhea continues to be a major cause of morbidity and mortality in children from developing countries. Determination of the frequency of diarrhea in an area, along with the proportion of disease caused by specific enteric agents of different origins, is considered the first step in controlling diarrheal diseases. Methodology: From 2005 to 2007, a hospital-based surveillance was conducted in two locations in Egypt to determine the causes of acute diarrhea in children younger than 5-years seeking treatment. Five additional enteric viral and parasitic pathogens were tested u

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Beckman, Amy K., and Patricia Ferrieri. "Prospective Investigation of an Automated PCR/Nucleic Acid Microarray-Based Platform for Enteric Pathogen Testing." Laboratory Medicine 50, no. 4 (2019): 390–95. http://dx.doi.org/10.1093/labmed/lmz022.

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Abstract Background The Verigene Enteric Pathogens Test (Luminex Corporation) is a polymerase chain reaction (PCR)/nucleic acid microarray-based assay targeting 8 bacterial and viral pathogens that cause diarrhea. Objective To compare traditional enteric culture methods with stool testing by Verigene EP (PCR/microarray). Methods Tests were performed using PCR/microarray between February and August 2016. All specimens also underwent culture for Salmonella and Shigella; specimens that tested positive for bacterial pathogen(s) had confirmatory cultures. Results Valid results were obtained for 99.

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Peterson, Christy-Lynn, David Alexander, Julie Chih-Yu Chen, et al. "Clinical Metagenomics Is Increasingly Accurate and Affordable to Detect Enteric Bacterial Pathogens in Stool." Microorganisms 10, no. 2 (2022): 441. http://dx.doi.org/10.3390/microorganisms10020441.

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Stool culture is the gold standard method to diagnose enteric bacterial infections; however, many clinical laboratories are transitioning to syndromic multiplex PCR panels. PCR is rapid, accurate, and affordable, yet does not yield subtyping information critical for foodborne disease surveillance. A metagenomics-based stool testing approach could simultaneously provide diagnostic and public health information. Here, we evaluated shotgun metagenomics to assess the detection of common enteric bacterial pathogens in stool. We sequenced 304 stool specimens from 285 patients alongside routine diagn

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Holcomb, David A., Vanessa Monteiro, Drew Capone, et al. "Long-term impacts of an urban sanitation intervention on enteric pathogens in children in Maputo city, Mozambique: study protocol for a cross-sectional follow-up to the Maputo Sanitation (MapSan) trial 5 years postintervention." BMJ Open 13, no. 6 (2023): e067941. http://dx.doi.org/10.1136/bmjopen-2022-067941.

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IntroductionWe previously assessed the effect of an onsite sanitation intervention in informal neighbourhoods of urban Maputo, Mozambique on enteric pathogen detection in children after 2 years of follow-up (Maputo Sanitation (MapSan) trial, ClinicalTrials.gov:NCT02362932). We found significant reductions inShigellaandTrichurisprevalence but only among children born after the intervention was delivered. In this study, we assess the health impacts of the sanitation intervention after 5 years among children born into study households postintervention.Methods and analysisWe are conducting a cross

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Wagner, Darlene D., Heather A. Carleton, Eija Trees, and Lee S. Katz. "Evaluating whole-genome sequencing quality metrics for enteric pathogen outbreaks." PeerJ 9 (November 25, 2021): e12446. http://dx.doi.org/10.7717/peerj.12446.

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Background Whole genome sequencing (WGS) has gained increasing importance in responses to enteric bacterial outbreaks. Common analysis procedures for WGS, single nucleotide polymorphisms (SNPs) and genome assembly, are highly dependent upon WGS data quality. Methods Raw, unprocessed WGS reads from Escherichia coli, Salmonella enterica, and Shigella sonnei outbreak clusters were characterized for four quality metrics: PHRED score, read length, library insert size, and ambiguous nucleotide composition. PHRED scores were strongly correlated with improved SNPs analysis results in E. coli and S. en

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Finlayson-Trick, Emma, Bronwyn Barker, Selina Manji, Sherilee L. Harper, Cedric P. Yansouni, and David M. Goldfarb. "Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?" Gastrointestinal Disorders 3, no. 3 (2021): 113–26. http://dx.doi.org/10.3390/gidisord3030012.

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The Canadian Arctic has a long history with diarrheal disease, including outbreaks of campylobacteriosis, giardiasis, and salmonellosis. Due to climate change, the Canadian Arctic is experiencing rapid environmental transformation, which not only threatens the livelihood of local Indigenous Peoples, but also supports the spread, frequency, and intensity of enteric pathogen outbreaks. Advances in diagnostic testing and detection have brought to attention the current burden of disease due to Cryptosporidium, Campylobacter, and Helicobacter pylori. As climate change is known to influence pathogen

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Capone, Drew, Petros Chigwechokha, Francis L. de los Reyes, et al. "Impact of sampling depth on pathogen detection in pit latrines." PLOS Neglected Tropical Diseases 15, no. 3 (2021): e0009176. http://dx.doi.org/10.1371/journal.pntd.0009176.

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Wastewater based epidemiology (WBE) is increasingly used to provide decision makers with actionable data about community health. WBE efforts to date have primarily focused on sewer-transported wastewater in high-income countries, but at least 1.8 billion people in low- and middle-income countries (LMIC) use onsite sanitation systems such as pit latrines and septic tanks. Like wastewater, fecal sludges from such systems offer similar advantages in community pathogen monitoring and other epidemiological applications. To evaluate the distribution of enteric pathogens inside pit latrines–which cou

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Prentice, Michael B., Keith D. James, Julian Parkhill, et al. "Yersinia pestis pFra Shows Biovar-Specific Differences and Recent Common Ancestry with aSalmonella enterica Serovar Typhi Plasmid." Journal of Bacteriology 183, no. 8 (2001): 2586–94. http://dx.doi.org/10.1128/jb.183.8.2586-2594.2001.

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ABSTRACT Population genetic studies suggest that Yersinia pestis, the cause of plague, is a clonal pathogen that has recently emerged from Yersinia pseudotuberculosis. Plasmid acquisition is likely to have been a key element in this evolutionary leap from an enteric to a flea-transmitted systemic pathogen. However, the origin of Y. pestis-specific plasmids remains obscure. We demonstrate specific plasmid rearrangements in different Y. pestis strains which distinguish Y. pestis bv. Orientalis strains from other biovars. We also present evidence for plasmid-associated DNA exchange between Y. pes

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KOLB, E. ANDERS, STEPHEN C. EPPES, and JOEL D. KLEIN. "Vibrio fluvialis: An Underrecognized Enteric Pathogen in Infants?" Southern Medical Journal 90, no. 5 (1997): 544–45. http://dx.doi.org/10.1097/00007611-199705000-00017.

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Kaur, P., A. Chakraborti, and A. Asea. "EnteroaggregativeEscherichia coli: An Emerging Enteric Food Borne Pathogen." Interdisciplinary Perspectives on Infectious Diseases 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/254159.

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EnteroaggregativeEscherichia coli(EAEC) are quite heterogeneous category of an emerging enteric pathogen associated with cases of acute or persistent diarrhea worldwide in children and adults, and over the past decade has received increasing attention as a cause of watery diarrhea, which is often persistent. EAEC infection is an important cause of diarrhea in outbreak and non-outbreak settings in developing and developed countries. Recently, EAEC has been implicated in the development of irritable bowel syndrome, but this remains to be confirmed. EAEC is defined as a diarrheal pathogen based o

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Fankem, S., D. Kennedy, C. Enriquez, and C. Gerba. "Assessment of Enteric Pathogen Exposure in Public Toilets." Epidemiology 17, Suppl (2006): S457. http://dx.doi.org/10.1097/00001648-200611001-01228.

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Munyemana, Jean Bosco, Jean Claude Kabayiza, Eric Seruyange, et al. "Non-Secretor Status Due to FUT2 Stop Mutation Is Associated with Reduced Rotavirus Infections but Not with Other Enteric Pathogens in Rwandan Children." Microorganisms 13, no. 5 (2025): 1071. https://doi.org/10.3390/microorganisms13051071.

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Enteric pathogens remain a health threat for children in low-income countries. A single nucleotide polymorphism (SNP) in the FUT2 gene that precludes the expression of fucosyltransferase 2 has been reported to influence the susceptibility to rotavirus and norovirus infections. The aim of this study was to investigate the association between G428A at rs601338 (stop codon variant) in the FUT2 gene and a range of enteric pathogens in children under 5 years of age. Rectal swab samples from 668 children (median age 13.6 months, 51% males, 93% rotavirus vaccinated, 468 with diarrhea) from Rwanda wer

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Sekirov, Inna, Nicola M. Tam, Maria Jogova, et al. "Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection." Infection and Immunity 76, no. 10 (2008): 4726–36. http://dx.doi.org/10.1128/iai.00319-08.

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ABSTRACT Intestinal microbiota comprises microbial communities that reside in the gastrointestinal tract and are critical to normal host physiology. Understanding the microbiota's role in host response to invading pathogens will further advance our knowledge of host-microbe interactions. Salmonella enterica serovar Typhimurium was used as a model enteric pathogen to investigate the effect of intestinal microbiota perturbation on host susceptibility to infection. Antibiotics were used to perturb the intestinal microbiota. C57BL/6 mice were treated with clinically relevant doses of streptomycin

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Colston, Josh M., Thomas G. Flynn, Andrea H. Denton, et al. "Updating global estimates of pathogen-attributable diarrhoeal disease burden: a methodology and integrated protocol for a broad-scope systematic review of a syndrome with diverse infectious aetiologies." BMJ Open 15, no. 4 (2025): e093018. https://doi.org/10.1136/bmjopen-2024-093018.

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IntroductionSustaining declines in global infectious disease burden will increasingly require efforts targeted to specific aetiological agents and common transmission pathways, particularly in this era of global change and human interconnectivity accelerating transmission and emergence of infectious pathogens. Systematic reviews and meta-analyses can be an effective and resource-efficient method for synthesising evidence regarding disease epidemiology for a wide range of pathogens and are the evidence source used by initiatives like the Planetary Child Health and Enterics Observatory (Plan-EO)

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Dawson, Daniel, David Rasmussen, Xinxia Peng, and Cristina Lanzas. "Inferring environmental transmission using phylodynamics: a case-study using simulated evolution of an enteric pathogen." Journal of The Royal Society Interface 18, no. 179 (2021): 20210041. http://dx.doi.org/10.1098/rsif.2021.0041.

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Indirect (environmental) and direct (host–host) transmission pathways cannot easily be distinguished when they co-occur in epidemics, particularly when they occur on similar time scales. Phylodynamic reconstruction is a potential approach to this problem that combines epidemiological information (temporal, spatial information) with pathogen whole-genome sequencing data to infer transmission trees of epidemics. However, factors such as differences in mutation and transmission rates between host and non-host environments may obscure phylogenetic inference from these methods. In this study, we us

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Rohilla, Ranjana, Mohit Bhatia, Pratima Gupta, Arpana Singh, Ravi Shankar, and Balram Ji Omar. "Salmonella osteomyelitis: A rare extraintestinal manifestation of an endemic pathogen." Journal of Laboratory Physicians 11, no. 02 (2019): 164–70. http://dx.doi.org/10.4103/jlp.jlp_165_18.

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Abstract Salmonella enterica serovar Typhi and Paratyphi usually cause enteric fever in humans characterized by fever and gastrointestinal symptoms such as diarrhea. Bacteremia is a constant feature of enteric fever, and occasionally, dissemination of bacilli throughout the body results in the establishment of one or more localized foci of persisting infection. This happens especially in patients with preexisting conditions such as hemoglobinopathies, previous joint trauma, surgery, connective tissue diseases, lymphoma, diabetes, alcoholism, immunosuppressive state, and extremes of ages. Rarel

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