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Journal articles on the topic 'Enterococcus faecalis – drug effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Chockalingam, Shabbarish, Preetha S, Jeevitha M, and Lavanya Pratap. "Antibacterial Effects of Capparis decidua Fruit Mediated Selenium Nanoparticles." Journal of Evolution of Medical and Dental Sciences 9, no. 40 (2020): 2947–50. http://dx.doi.org/10.14260/jemds/2020/646.

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BACKGROUND Capparis decidua and Selenium have several antibacterial properties along with other highly desirable properties, but for long they have not been explored. Nanoparticles are efficient in transporting drugs as they are easily absorbed by the body due to their small size. We wanted to evaluate the antibacterial activity of Capparis decidua mediated selenium nanoparticles against Streptococcus mutans, Lactobacillus, and Enterococcus faecalis. METHODS 4 wells were dug in three Petri dishes of Agar which were coated with a layer of bacteria, Streptococcus mutans, Lactobacillus and Entero

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Hilgeroth, Andreas, Kaveh Yasrebi, Sibel Suzen, Tobias Hertlein, Knut Ohlsen, and Michael Lalk. "Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains." Medicinal Chemistry 15, no. 8 (2019): 833–39. http://dx.doi.org/10.2174/1573406415666190208170126.

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Background: Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments. Objective: Bisindole compounds with antibacterial activities which formally result from the reaction of an aldehyde with indole motivated to investigate the reaction of a dialdehyde and indole to give novel structures with potential antibacterial activities. Methods: Compounds were yielded by chemical synthesis and purified using column chromatography. The antibacterial activity was determined as minimal inhibitor

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Motahari, Paria, Hossein Samadi Kafil, and Zahra Taheri Bonab. "In vitro evaluation of antibacterial effect of combination of honey and Aloe vera extract against Enterococcus faecalis and Escherichia coli." Advances in Bioscience and Clinical Medicine 9, no. 1 (2021): 4. http://dx.doi.org/10.7575/aiac.abcmed.v.9n.1p.4.

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Antimicrobial agents are used as intra-canal drugs or canal cleaners for complete dental root canal cleaning. This new study attempts to compare the antibacterial effect of 2% chlorhexidine and combination of honey and Aloe vera extract (H-Av mixture) against Enterococcus faecalis (E.faecalis) and Escherichia coli (E.coli) which are the most important pathogens isolated from infectious root canals. Enterococcus faecalis (ATCC® 29212™) and Escherichia coli (ATCC® 25922™) were cultured in the tryptic soy broth medium. Dilution of H-Av mixture by the method of macrodilution to determine Minimum I

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Quan, Lin-Hu, Chuanhai Zhang, Meng Dong, et al. "Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation." Gut 69, no. 7 (2019): 1239–47. http://dx.doi.org/10.1136/gutjnl-2019-319114.

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ObjectiveDietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by gut microbiota. Ginseng has been reported to aid in body weight management, however, its mechanism of action is not yet clear. In this study, we focused on the potential modulating effect of ginseng on gut microbiota, aiming to identify specific strains and their metabolites, especially long-chain fatty acids (LCFA), which mediate the anti-obesity effects of ginseng.DesignDb/db mice were gavaged with ginseng extract (GE) and the effects of GE on gu

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Solheim, Margrete, Ågot Aakra, Heidi Vebø, Lars Snipen, and Ingolf F. Nes. "Transcriptional Responses of Enterococcus faecalis V583 to Bovine Bile and Sodium Dodecyl Sulfate." Applied and Environmental Microbiology 73, no. 18 (2007): 5767–74. http://dx.doi.org/10.1128/aem.00651-07.

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ABSTRACT Resistance to bile is a prerequisite property of the gastrointestinal bacterial flora. Bile acids are powerful detergents, and resistance to sodium dodecyl sulfate (SDS) has therefore often been considered relevant to studies of bile resistance. We have studied the effects of bovine bile (BB) and SDS on Enterococcus faecalis V583 by traditional growth studies and microarrays. Transcriptional responses were studied by time course experiments. In the presence of BB (V583-BB) or SDS (V583-SDS), 308 and 209 genes were identified as differentially expressed at one or more time points, resp

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Pertusati, Fabrizio, Elisa Pileggi, Jennifer Richards, et al. "Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials." Journal of Antimicrobial Chemotherapy 75, no. 10 (2020): 2864–78. http://dx.doi.org/10.1093/jac/dkaa268.

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Abstract Objectives Following a drug repurposing approach, we aimed to investigate and compare the antibacterial and antibiofilm activities of different classes of phosphate prodrugs (HepDirect, cycloSal, SATE and mix SATE) of antiviral and anticancer FDA-approved nucleoside drugs [zidovudine (AZT), floxouridine (FUDR) and gemcitabine (GEM)] against a variety of pathogenic Gram-positive and -negative bacteria. Methods Ten prodrugs were synthesized and screened for antibacterial activity against seven Gram-negative and two Gram-positive isolates fully susceptible to traditional antibiotics, alo

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Mikamo, Hiroshige, Kyoko Kawazoe, Yasumasa Sato, Koji Izumi, and Teruhiko Tamaya. "Therapeutic Effects of Cefozopran on Polymicrobial Infections Associated with Enterococcus faecalis in a Rat Pyometra Model." Chemotherapy 44, no. 2 (1998): 103–7. http://dx.doi.org/10.1159/000007100.

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8

Santana de Oliveira, Mozaniel, Jorddy Neves da Cruz, Wanessa Almeida da Costa, et al. "Chemical Composition, Antimicrobial Properties of Siparuna guianensis Essential Oil and a Molecular Docking and Dynamics Molecular Study of its Major Chemical Constituent." Molecules 25, no. 17 (2020): 3852. http://dx.doi.org/10.3390/molecules25173852.

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The essential oil of Siparuna guianensis was obtained by hydrodistillation. The identification of the chemical compounds was performed by gas chromatography coupled with mass spectrometry (GC/MS). Antimicrobial activity was investigated for four microorganisms: Streptococcus mutans (ATCC 3440), Enterococcus faecalis (ATCC 4083), Escherichia coli (ATCC 25922), and Candida albicans (ATCC-10231). The studies of doping and molecular dynamics were performed with the molecule that presented the highest concentration of drug–target proteins, 1IYL (C. albicans), 1C14 (E. coli), 2WE5 (E. faecalis), and

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Khaledi, Mansoor, Fatemeh Khaledi, Majid Asadi-Samani, Abolfazl Gholipour, and Ahmad Mahmoodi Kouhi. "Phytochemical evaluation and antibacterial effects of Medicago sativa, Onosma sericeum, Parietaria judaica L., Phlomis persica and Echinophora platyloba DC. on Enterococcus faecalis." Biomedical Research and Therapy 5, no. 1 (2018): 1941–51. http://dx.doi.org/10.15419/bmrat.v5i1.408.

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Background: Since drug resistance has become one of the predominant problems of health worldwide, it is necessary to use new methods to combat drug-resistant bacteria. In this regard, medicinal plants are considered one of the richest sources to produce antibiotics. The aim of this study was to investigate the antibacterial effects as well as total phenolic and flavonoid contents of a number of medicinal plants collected from the Chaharmahal and Bakhtiari provinces of India, in order to investigate their potential use for the production of new antibiotics. Materials and Methods: In this

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10

Zhou, Shi, Zhong, et al. "Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and its Truncated Analogues." Biomolecules 9, no. 6 (2019): 249. http://dx.doi.org/10.3390/biom9060249.

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Antimicrobial peptides (AMPs) are considered as a promising agent to overcome the drug-resistance of bacteria. Large numbers of AMPs have been identified from the skin secretion of Rana pipiens, including brevinins, ranatuerins, temporins and esculentins. In this study, the cDNA precursor of a broad-spectrum antimicrobial peptide, ranatuerin-2Pb, was cloned and identified. Additionally, two truncated analogues, RPa and RPb, were synthesised to investigate the structure-activity relationship of ranatuerin-2Pb. RPa lost antimicrobial activity against Candida albicans, MRSA, Enterococcus faecalis

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Tozatti, Marcos G., Daniele S. Ferreira, Lúzio G. Bocalon Flauzino, et al. "Activity of the Lichen Usnea steineri and its Major Metabolites against Gram–positive, Multidrug–resistant Bacteria." Natural Product Communications 11, no. 4 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100419.

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The antimicrobial activity and possible synergistic effects of extracts and compounds isolated from Usnea steineri were evaluated against four resistant bacterial species. A phytochemical study of the acetone extract of U. steineri resulted in the isolation and characterization of difractaic acid and (+)–usnic acid as the main compounds. The acetone extract showed strong activity (less than 10 μg/mL) against resistant strains of Staphylococcus epidermidis and Enterococcus faecalis, and (+)–usnic acid exhibited strong activity against S. epidermidis (MIC 3.12 μg/mL), S. aureus and S. haemolytic

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Labbaf, Sheyda, Harry Horsley, Ming-Wei Chang, et al. "An encapsulated drug delivery system for recalcitrant urinary tract infection." Journal of The Royal Society Interface 10, no. 89 (2013): 20130747. http://dx.doi.org/10.1098/rsif.2013.0747.

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One of the hallmarks of urinary tract infection, a serious global disease, is its tendency to recur. Uropathogenic bacteria can invade cells lining the bladder, where they form longer-term intracellular reservoirs shielded from antibiotics, re-emerging at a later date to initiate flare-ups. In these cases, only lengthy systemic antibiotic treatment can eradicate all the reservoirs. Yet, long courses of antibiotics are not ideal, as they can lead to side effects and an increase in antibiotic resistance. Moreover, most antibiotics lose some potency by the time they reach the bladder, and many ca

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Damayanti, Lisda, Ida Ayu Evaangelina, Avi Laviana, Yetty Herdiyati, and Dikdik Kurnia. "Antibacterial Activity of Buah Merah (Pandanus conoideus Lam.) Against Bacterial Oral Pathogen of Streptococcus sanguinis ATCC10556, Streptococcus mutans ATCC 25175, and Enterococcus faecalis ATCC 29212: An in Vitro Study." Open Dentistry Journal 14, no. 1 (2020): 113–19. http://dx.doi.org/10.2174/18742106020140113.

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Background: Caries and periodontitis are dental diseases caused by bacteria of S. sanguinis, S. mutans, and E. faecalis with three main etiological factors of the host, substrate, and time. Objective: This study proposed to investigate the antibacterial effects of Buah Merah (Pandanus conoideus Lam.) against oral bacteria of E.faecalis, S. mutans, and S. sanguinis. Materials and Methods: The Buah Merah was extracted with different solvents to yield n-hexane, ethyl acetate, methanol, and H2O extracts. The concentrations of single and mixture extracts were adjusted for antibacterial assay agains

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Riaz, Sundus, Nosheen Fatima Rana, Irshad Hussain, et al. "Effect of Flavonoid-Coated Gold Nanoparticles on Bacterial Colonization in Mice Organs." Nanomaterials 10, no. 9 (2020): 1769. http://dx.doi.org/10.3390/nano10091769.

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Multidrug resistance (MDR) has been a potentiator for the exploration of antibiotics. Nano drug delivery systems have opened new avenues to overcome this challenge. Although antibacterial nanocarriers are extensively realized, their effect on the bacteria residing inside the tissues and their toxicity is rarely explored. This study investigated the effects of flavonoid coated gold nanoparticles (FAuNPs) on the colonization of Enterococcus faecalis in the mouse liver and kidneys. Flavonoids were extracted from the leaves of Berberis lycium Royle and used to stabilize gold following a green synt

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Politeo, Olivera, Mirjana Skocibusic, Ivana Carev, et al. "Phytochemical Profiles of Volatile Constituents from Centaurea ragusina Leaves and Flowers and their Antimicrobial Effects." Natural Product Communications 7, no. 8 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700831.

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The volatile oils obtained from the leaves and flowers of the Croatian endemic plant Centaurea ragusina L. were evaluated for antimicrobial activity. The chemical compositions, determined by GC and GC-MS, were complex, with sesquiterpenes the most abundant class of compound. Nonterpene hydrocarbons were also identified in high quantities, while acids and ketones were found in high quantities only in the leaf volatile oil. Aldehydes, alcohols, esters and other compounds were identified in lower quantities. Antimicrobial effects of the volatile samples were investigated by using the disc diffusi

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Veith, Nadine, Margrete Solheim, Koen W. A. van Grinsven, et al. "Using a Genome-Scale Metabolic Model of Enterococcus faecalis V583 To Assess Amino Acid Uptake and Its Impact on Central Metabolism." Applied and Environmental Microbiology 81, no. 5 (2014): 1622–33. http://dx.doi.org/10.1128/aem.03279-14.

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ABSTRACTIncreasing antibiotic resistance in pathogenic bacteria necessitates the development of new medication strategies. Interfering with the metabolic network of the pathogen can provide novel drug targets but simultaneously requires a deeper and more detailed organism-specific understanding of the metabolism, which is often surprisingly sparse. In light of this, we reconstructed a genome-scale metabolic model of the pathogenEnterococcus faecalisV583. The manually curated metabolic network comprises 642 metabolites and 706 reactions. We experimentally determined metabolic profiles ofE. faec

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Alva, Mariana, Susana Popich, Susana Borkosky, Elena Cartagena, and Alicia Bardón. "Bioactivity of the Essential Oil of an Argentine Collection of Acanthospermum hispidum (Asteraceae)." Natural Product Communications 7, no. 2 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700235.

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The essential oil of an Argentine collection of the annual herb Acanthospermum hispidum DC. (Asteraceae), which contains the sesquiterpenoids β-caryophyllene (35.2%), α-bisabolol (11.4%), and germacrene D (11.1%) as major constituents, displayed molluscicidal effects on an adult population of Biomphalaria peregrina Orbigny (LD50 37.8 μg/mL) and produced alteration of the feeding and oviposition behavior of the polyphagous insect Spodoptera frugiperda Smith when incorporated in the larval diet at 250 μg/g. In addition, a selective antibacterial activity was observed against pathogenic strains o

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Sharma, Anupama, and Kevin B. Wood. "Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress." ISME Journal 15, no. 10 (2021): 3019–33. http://dx.doi.org/10.1038/s41396-021-00982-2.

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AbstractAntibiotic resistance in microbial communities reflects a combination of processes operating at different scales. In this work, we investigate the spatiotemporal dynamics of bacterial colonies comprised of drug-resistant and drug-sensitive cells undergoing range expansion under antibiotic stress. Using the opportunistic pathogen Enterococcus faecalis with plasmid-encoded β-lactamase, we track colony expansion dynamics and visualize spatial patterns in fluorescently labeled populations exposed to antibiotics. We find that the radial expansion rate of mixed communities is approximately c

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Kovanda, Lauren, Wen Zhang, Xiaohong Wei, et al. "In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria." Molecules 24, no. 20 (2019): 3770. http://dx.doi.org/10.3390/molecules24203770.

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The objective of this study was to determine the in vitro antimicrobial activity of several organic acids and their derivatives against Gram-positive (G+) and Gram-negative (G−) bacteria. Butyric acid, valeric acid, monopropionin, monobutyrin, monovalerin, monolaurin, sodium formate, and ProPhorce—a mixture of sodium formate and formic acid (40:60 w/v)—were tested at 8 to 16 concentrations from 10 to 50,000 mg/L. The tested bacteria included G− bacteria (Escherichia coli, Salmonella enterica Typhimurium, and Campylobacter jejuni) and G+ bacteria (Enterococcus faecalis, Clostridium perfringens,

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Eggleston, Mark, Soon-young Park, and Richard H. Parker. "Clinical Pharmacology of Antibiotics: Review of Imipenem." Infection Control 7, no. 6 (1986): 333–38. http://dx.doi.org/10.1017/s0195941700064377.

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AbstractImipenem, a new carbapenem ß-lactam broad-spectrum antibiotic, is highly active in vitro against most aerobic and anaerobic gram-positive and gram-negative bacteria isolated from infectious diseases of human beings. Except for enterococci and methicillin-resistant staphylococci most gram-positive cocci are inhibited by <2 μg/ml. Although the MIC-90 of methicillin-resistant staphylococci may be <4 μg/ml, these bacteria are usually resistant to imipenem by modified testing methods. The enterococcus, S. faecalis, has an MIC-90 of <8 μg/ml but bactericidal concentration may be muc

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Dalby, Andrew B., Daniel N. Frank, Allison L. St. Amand, Alison M. Bendele, and Norman R. Pace. "Culture-Independent Analysis of Indomethacin-Induced Alterations in the Rat Gastrointestinal Microbiota." Applied and Environmental Microbiology 72, no. 10 (2006): 6707–15. http://dx.doi.org/10.1128/aem.00378-06.

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ABSTRACT Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for a variety of inflammatory conditions; however, the benefits of this class of drugs are accompanied by deleterious side effects, most commonly gastric irritation and ulceration. NSAID-induced ulceration is thought to be exacerbated by intestinal microbiota, but previous studies have not identified specific microbes that contribute to these adverse effects. In this study, we conducted a culture-independent analysis of ∼1,400 bacterial small-subunit rRNA genes associated with the small intestines and mesenteric lym

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Makhafola, Tshepiso J., Babatunde B. Samuel, Esameldin E. Elgorashi, and Jacobus N. Eloff. "Ochnaflavone and Ochnaflavone 7-O-Methyl Ether two Antibacterial Biflavonoids from Ochna pretoriensis (Ochnaceae)." Natural Product Communications 7, no. 12 (2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701216.

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The acetone extract of Ochna pretoriensis was evaluated for antibacterial activity using bioautography and serial microplate dilution methods against four nosocomial bacterial pathogens namely: Escherichia coli, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa. A bioassay-guided fractionation of the crude extract led to the isolation of two antibacter ial biflavonoids, ochnaflavone and ochnaflavone 7- O-methyl ether. Gram-negative bacteria were more sensitive to the isolated compounds than the Gram-positive bacteria (MIC values: 31.3 μg/mL for P. aeruginosa and 62.5 μg/m

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Maltas, Jeff, Brian Krasnick, and Kevin B. Wood. "Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics." Molecular Biology and Evolution 37, no. 5 (2019): 1394–406. http://dx.doi.org/10.1093/molbev/msz303.

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Abstract Evolutionary adaptation of bacteria to nonantibiotic selective forces, such as osmotic stress, has been previously associated with increased antibiotic resistance, but much less is known about potentially sensitizing effects of nonantibiotic stressors. In this study, we use laboratory evolution to investigate adaptation of Enterococcus faecalis, an opportunistic bacterial pathogen, to a broad collection of environmental agents, ranging from antibiotics and biocides to extreme pH and osmotic stress. We find that nonantibiotic selection frequently leads to increased sensitivity to other

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Shafaghat, Ali, and Khodamali Oji. "Nepetalactone Content and Antibacterial Activity of the Essential Oils from Different Parts of Nepeta persica." Natural Product Communications 5, no. 4 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500427.

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The essential oils from the flower, leaf, stem and root of Nepeta persica Boiss., analyzed by GC and GC/MS, were shown to contain 4aβ,7α,7aβ-nepetalactone (58.5%, 62.3%, 66.2% and 27.1%, respectively), and 4aα,7α,7aβ-nepetalactone (33.0%, 28.3%, 24.9% and 7.6%, respectively). The other main component of the flower and stem oils was α-pinene (3.6% and 4.4%) and of the leaf oil β-ocimene (3.6%). In the root oil, other main constituents were α-pinene (40.4%), α-amorphene (5.3%), γ-cadinene (2.9%), and cis-calamenene (2.5%). Nepetalactone was the major component of the flower, leaf and stem oils,

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Khoshkhounejad, Mehrfam, Mahsa Sobhi Afshar, Fereshteh Jabalameli, Mohammad Emaneini, and Mohammadreza Sharifian. "Cytotoxicity Evaluation of Minimum Antibacterial Values of Different Medicaments Used in Endodontic Regenerative Procedures." European Journal of Dentistry 13, no. 04 (2019): 514–20. http://dx.doi.org/10.1055/s-0039-3401369.

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Abstract Objectives This study aimed to evaluate the cytotoxicity of minimum antibacterial values of medicaments used in endodontic regeneration on stem cells. Materials and Methods “Minimum inhibitory concentration,” “minimum bactericidal concentration,” and “minimum biofilm inhibitory concentration” of triple and double antibiotic paste, a modified triple antibiotic paste (minocycline replaced by clindamycin), Augmentin, and calcium hydroxide were determined using Enterococcus faecalis (ATCC 29212) by microtiter plate method. Direct cytotoxic effects of drugs were evaluated by lactate dehydr

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Onyeji, CyprianO, DavidP Nicolau, CharlesH Nightingale та Laurine Bow. "Interferon-γ effects on activities of gentamicin and vancomycin against Enterococcus faecalis resistant to the drugs: an in vitro study with human neutrophils". International Journal of Antimicrobial Agents 11, № 1 (1999): 31–37. http://dx.doi.org/10.1016/s0924-8579(98)00085-5.

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Subedi, Yagya Prasad, and Cheng-Wei Tom Chang. "Cationic Anthraquinone Analogs as Selective Antimicrobials." Microbiology Insights 12 (January 2019): 117863611984780. http://dx.doi.org/10.1177/1178636119847809.

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Development of new antibiotics is always needed in the fight against growing threat from multiple drug–resistant bacteria, such as resistant Gram-negative (G−) Escherichia coli and Klebsiella pneumoniae. While the development of broad-spectrum antibiotics has attracted great attention, careful administration of these antibiotics is important to avoid adverse effects, like Clostridium difficile infection (CDI). The use of broad-spectrum antibiotics, for example, quinolones, can increase the risk of CDI by eradicating the protective bacteria in intestine and encouraging C difficile spore germina

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Shrestha, Rose, Astha Shakya, and Krishna Kumar Shrestha. "Phytochemical Screening and Antimicrobial Activity Of Asparagus Racemosus Willd. and Asparagus Curillus Buch.-Ham. Ex Roxb." Journal of Natural History Museum 29 (January 19, 2018): 91–102. http://dx.doi.org/10.3126/jnhm.v29i0.19041.

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Asparagus racemosus Willd. is an important medicinal plant of tropical and subtropical regions of Nepal and India. Its medicinal usage has been reported in the Indian and British Pharmacopoeias and in traditional systems of medicine such as Ayurveda, Unani, and Siddha. Asparagus curillus Buch-Ham.ex Roxb. is also one of the species found in higher altitude of Nepal. Its roots are used as substitute for A. racemosus. Phytochemical investigation was done for these two species of Nepalese Asparagus as per Methodology for Analysis of Vegetable Drugs by I. Ciulei.1982. Phytochemical screening revea

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Stochmal, Anna, Bartosz Skalski, Rostyslav Pietukhov, et al. "Evaluation of Antimicrobial, Antioxidant, and Cytotoxic Activity of Phenolic Preparations of Diverse Composition, Obtained from Elaeagnus rhamnoides (L.) A. Nelson Leaf and Twig Extracts." Molecules 26, no. 10 (2021): 2835. http://dx.doi.org/10.3390/molecules26102835.

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Although the major components of various organs of sea buckthorn have been identified (particularly phenolic compounds), biological properties of many of these phytochemicals still remain poorly characterized. In this study, we focused on the chemical composition and biological activity of preparations that were obtained from sea buckthorn twigs and leaves. The objective was to investigate cytotoxicity of these preparations against human fibroblast line HFF-1, using MTT reduction assay, their anti- or pro-oxidant activities against the effects of a biological oxidant -H2O2/Fe—on human plasma l

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Selin, Liisa K., Godfrey KM Harding, Margaret J. Thomson, James K. Kennedy, Barbara A. Urias, and Allan R. Ronald. "Comparison of Norfloxacin Versus Nalidixic Acid in Therapy of Acute Urinary Tract Infections." Canadian Journal of Infectious Diseases 1, no. 2 (1990): 35–40. http://dx.doi.org/10.1155/1990/482960.

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Thirty-seven adult patients with acute urinary tract infections (UTI) were randomized to receive either a seven day (lower UTI) or a 14 day (upper UTI) course of norfloxacin 400 mg orally twice daily, or nalidixic acid 1 g orally four times per day. Mean age, underlying disease and infecting organisms were similar in the two groups. Nine patients in the norfloxacin group and seven in the nalidixic acid group had presumptive evidence of upper UTI. Overall, 12 patients had antibody-coated bacteria-positive infections. The infecting organisms were:Escherichia coli(27), coagulase-negative staphylo

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Dzitko, Jakub, Przemyslaw Zalewski, Daria Szymanowska, Piotr Garbacki, Magdalena Paczkowska, and Judyta Cielecka Piontek. "The Influence of Excipients on the Physicochemical and Biological Properties of a Bactericidal, Labile Ester Prodrug in a Salt Form – A Case Study of Cefetamet Pivoxil Hydrochloride." JOURNAL OF ADVANCES IN CHEMISTRY 15, no. 2 (2018): 6218–34. http://dx.doi.org/10.24297/jac.v15i2.7560.

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The article presents an innovative approach to a bactericidal drug design based on a cephem prodrug analogue – cefetamet pivoxil hydrochloride. The emergence of cefetamet pivoxil hydrochloride excipient systems (mannitol, hydroxypropyl methyl cellulose, pregelatinised starch, lactose monohydrate, magnesium stearate, polyvinylpyrrolidone) caused changes in the physicochemical properties of cefetamet pivoxil hydrochloride. They are significant for planning the development of an innovative pharmaceutical formulation. The biological activity profile of the prodrug was also modified. FTIR spectra w

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Pecarski, Danijela, Zorica Knezevic-Jugovic, Suzana Dimitrijevic-Brankovic, Katarina Mihajilovski, and Slobodan Jankovic. "Preparation, characterization and antimicrobial activity of chitosan microparticles with thyme essential oil." Chemical Industry 68, no. 6 (2014): 721–29. http://dx.doi.org/10.2298/hemind140415048p.

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Considering the therapeutic effects of formulations with violate essential oils, development of an available drug delivery system is of great interest, especially assuming the fact that using essential oils as antimicrobial agents is a rather expanded in antimicrobial therapy nowadays. In this work, chitosan microparticles with encapsulated thyme essential oil were prepared by the emulsion cross-linking method. The effect of thyme oil and glutaraldehyde initial concentrations on particle size, morphology, and particle size distribution was investigated. In addition, the influence of these para

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Pestrikova, Tatiana Yu, Elena A. Yurasova, and Igor V. Yurasov. "A strategy of antimicrobial therapy of pelvic inflammatory diseases at antibiotic resistance of microbial pathogens." Gynecology 21, no. 1 (2019): 60–63. http://dx.doi.org/10.26442/20795696.2019.1.190237.

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Relevance. Antibiotic resistance of microbial pathogens is an interdisciplinary and interstate problem of major medical and socio-economic importance. If multiresistant microbial flora is detected in patients with acute or chronic forms of pelvic inflammatory diseases alternative antimicrobial combined therapy an advisability should be considered. Current trends of an increase in multiresistant gram-negative infections along with limited range of alternative treatment options dictate a need for further research. Study of alternative antibiotics effectiveness in pelvic inflammatory diseases tre

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Rasool, Shiekh Ajaz, Fehmida Mirza, Hera Waheed, and Muhammad Munir. "Probiotics as Human Health Promoters." RADS Journal of Biological Research & Applied Sciences 9, no. 2 (2018): 102–5. http://dx.doi.org/10.37962/jbas.v9i2.152.

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Probiotics (Pro-life live entities) provide the health and well being with multitude of beneficial effects on humans and animals (and relief against varied disorders). Probiotics may manage lactose intolerance, elevate immune profile, prevent colorectal cancers, reduce cholesterol and triglyceride profile, lowering blood pressure and inflammatory process. They also prevent osteoporosis, allergic reactions and help suppress H. pylori infections and other pathological manifestations. Microbial metabolites (even in the absence of live entities) may exert (analogous) effects on signal pathwa

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Donadu, Matthew Gavino, Nhan Trong Le, Duc Viet Ho, et al. "Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk." Antibiotics 9, no. 6 (2020): 334. http://dx.doi.org/10.3390/antibiotics9060334.

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The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staph

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Čech Barabaszová, Karla, Sylva Holešová, Kateřina Šulcová, Marianna Hundáková, and Barbora Thomasová. "Effects of Ultrasound on Zinc Oxide/Vermiculite/Chlorhexidine Nanocomposite Preparation and Their Antibacterial Activity." Nanomaterials 9, no. 9 (2019): 1309. http://dx.doi.org/10.3390/nano9091309.

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Microbial infection and biofilm formation are both problems associated with medical implants and devices. In recent years, hybrid organic-inorganic nanocomposites based on clay minerals have attracted significant attention due to their application potential in the field of antimicrobial materials. Organic drug/metal oxide hybrids exhibit improved antimicrobial activity, and intercalating the above materials into the interlayer of clay endows a long-term and controlled-release behavior. Since antimicrobial activity is strongly related to the structure of the material, ultrasonic treatment appea

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Novais, Juliana S., Aline C. Rosandiski, Carolina M. de Carvalho, et al. "Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione)." Current Topics in Medicinal Chemistry 20, no. 2 (2020): 121–31. http://dx.doi.org/10.2174/1568026619666191210160342.

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Background: Antibacterial resistance is a serious public health problem infecting millions in the global population. Currently, there are few antimicrobials on the market against resistant bacterial infections. Therefore, there is an urgent need for new therapeutic options against these strains. Objective: In this study, we synthesized and evaluated ten Bis(2-hydroxynaphthalene-1,4-dione) against Gram-positive strains, including a hospital Methicillin-resistant (MRSA), and Gram-negative strains. Method: The compounds were prepared by condensation of aldehydes and lawsone in the presence of dif

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Morrisette, Taylor, Matthew A. Miller, Brian T. Montague, Gerard R. Barber, R. Brett McQueen, and Martin Krsak. "On- and off-label utilization of dalbavancin and oritavancin for Gram-positive infections." Journal of Antimicrobial Chemotherapy 74, no. 8 (2019): 2405–16. http://dx.doi.org/10.1093/jac/dkz162.

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AbstractBackgroundLong-acting lipoglycopeptides (laLGPs) are FDA approved only for acute bacterial skin and skin structure infections (ABSSSIs). However, these antibiotics show promise for off-label use, reductions in hospital length of stay (LOS) and healthcare cost savings.ObjectivesTo assess the effectiveness, safety, impact on LOS and estimated cost savings from laLGP treatment for Gram-positive infections.MethodsRetrospective cohort of adult patients who received at least one dose of laLGPs at the University of Colorado Health system. Descriptive statistics were utilized for analysis.Resu

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Farina, C., G. Russello, P. Chinello, et al. "In vitro Activity Effects of Twelve Antibiotics Alone and in Association against Twenty-Seven Enterococcus faecalis Strains Isolated from Italian Patients with Infective Endocarditis: High in vitro Synergistic Effect of the Association Ceftriaxone-Fosfomycin." Chemotherapy 57, no. 5 (2011): 426–33. http://dx.doi.org/10.1159/000330458.

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SIMA OBIANG, Cédric, Rick-Léonid Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, Joseph-Privat Ondo, Louis-Clément Obame-Engonga, and Edouard Nsi-Emvo. "Chemical composition, antioxidant and antimicrobial activities of stem barks of Englerina gabonensis Engler and Sterculia tragacantha Lindl from Gabon." International Journal of Phytomedicine 9, no. 3 (2017): 501. http://dx.doi.org/10.5138/09750185.2124.

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<p>Aim of this work was to evaluate the phytochemical constituents, antioxidant and antimicrobial potential of water-acetone, water-ethanol and water extracts of <em>Englerina gabonensis</em> and <em>Sterculia tragacantha</em>.Presence of phenols was evaluated to estimate the effects of plants on microbial diseases. Water-acetone, water-ethanol and water extracts were examined for antioxidant activities. All plant extracts were tested against six reference strains, eleven clinical isolates and two fungal strains.</p><p>Phenolic content were highest in

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Viana, Altevir Rossato, Angelita Bottega, Marissa Bolson Serafin, et al. "In vitro biological activity of liposomal-containing antimony trioxide." Research, Society and Development 10, no. 11 (2021): e391101119755. http://dx.doi.org/10.33448/rsd-v10i11.19755.

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Antimonials are used as chemotherapy for leishmaniasis, but have limited results due to their toxicity and broad resistance already acquired by the parasites. Nanotechnology offers an alternative to reduce these effects through the use of biocompatible nanocarriers, which can be vectorized to the target site. In addition, the redirection of molecules, already developed for the treatment of other pathologies, has the advantage of being already approved for therapy by regulatory agencies. The present study addresses the production of liposomal vesicles containing antimony trioxide (LC Sb2O3), as

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Rajani Chowdary Akkina, Payala Vijayalakshmi, and Raaththika R. "Evaluation of Anti-microbial activity of methanolic extract of Costus igneus plant against multidrug-resistant pathogenic microorganisms." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3796–806. http://dx.doi.org/10.26452/ijrps.v11i3.2552.

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Costus igneus plants are highly active against the majority of Gram-negative and Gram-positive microorganisms. The purpose of the current study was intended to evaluate the anti-microbial potential of methanolic extract of Costus igneus over multidrug-resistant bacteria, specifically to methicillin, vancomycin, carbapenems, colistin. The study also focused on the antifungal activity of the plant extract against Candida species. Phytochemical analysis was conducted to identify the presence of the active chemicals such as steroids, alkaloid, flavonoids, polyphenols, terpenoids, saponin, tannin,

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Benyoucef, Fatima, Mohammed El Amine Dib, Boufeldja Tabti, Arrar Zoheir, Jean Costa, and Alain Muselli. "Synergistic Effects of Essential Oils of Ammoides verticillata and Satureja candidissima Against Many Pathogenic Microorganisms." Anti-Infective Agents 18, no. 1 (2020): 72–78. http://dx.doi.org/10.2174/2211352517666190227161811.

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Background: Antibiotic resistance is today one of the most serious threats to global health, food security and development. Due to the growing number of infections, treatment becomes more difficult, if not impossible, because of the loss of antibiotic efficacy. Objective: In the present investigation, the chemical composition of essential oils of Ammoides verticillata and Satureja candidissima and their synergistic effects on antimicrobial activities were investigated. Methods: The chemical composition of the essential oil was analyzed by Gas Chromatography (GC) and Gas Chromatography-Mass Spe

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Cybulska, Krystyna, and Teresa Krzyśko-Łupicka. "Antibiotics Resistance in Enterococcus Isolates From Poultry Waste." Ecological Chemistry and Engineering S 27, no. 2 (2020): 305–16. http://dx.doi.org/10.2478/eces-2020-0020.

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AbstractThe aim of the study was to evaluate the drug resistance of Enterococcus faecalis and Enterococcus faecium isolated from different types of poultry waste. The study material consisted of feather samples (duck, turkey, chicken), sludge and centrifuge sediment, originating from three poultry farms. The study was conducted in two stages; isolation and identification of Enterococcus bacteria from the waste and evaluation of their drug resistance using Kirby-Bauer method. Contamination of the poultry waste with Enterococcus isolates included E. faecium species (79 %) and E. faecalis (21 %).

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Das, Biswadeep, Chayna Sarkar, Debasmita Das, Amit Gupta, Arnav Kalra, and Shubham Sahni. "Telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant Gram-positive pathogens." Therapeutic Advances in Infectious Disease 4, no. 2 (2017): 49–73. http://dx.doi.org/10.1177/2049936117690501.

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Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA ( S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis). Telavancin has two

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S, Ololade Zacchaeus, Anuoluwa Iyadunni A, Adejuyitan Johnson A, and Uyaboerigha Daubotei I. "Black Velvet Tamarind: Phytochemical Analysis, Antiradical and Antimicrobial Properties of the Seed Extract for Human Therapeutic and Health Benefits." Journal of Phytopharmacology 10, no. 4 (2021): 249–55. http://dx.doi.org/10.31254/phyto.2021.10406.

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Black Velvet Tamarind (BVT) is a famous edible fruit with multiple therapeutic properties. The aim of this study was to determine the secondary metabolites and evaluate the medicinal activities of the seed extract of the plant in order to scientifically report its possible medicinal applications in food and pharmaceutical industries. The pulverized seed was extracted with methanol/ethylacetate (2:1) and the concentrated extract was analyzed using gas chromatography-mass spectrometry (GC-MS), the antioxidant capacity was evaluated using galvinoxyl and 2,2ʹ-diphenyl-1-picryl-hydrazyl (DPPH) assa

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Johnston, Lynette M., and Lee-Ann Jaykus. "Antimicrobial Resistance of Enterococcus Species Isolated from Produce." Applied and Environmental Microbiology 70, no. 5 (2004): 3133–37. http://dx.doi.org/10.1128/aem.70.5.3133-3137.2004.

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ABSTRACT The purpose of this study was to characterize the antibiotic resistance profiles of Enterococcus species isolated from fresh produce harvested in the southwestern United States. Among the 185 Enterococcus isolates obtained, 97 (52%) were Enterococcus faecium, 38 (21%) were Enterococcus faecalis, and 50 (27%) were other Enterococcus species. Of human clinical importance, E. faecium strains had a much higher prevalence of resistance to ciprofloxacin, tetracycline, and nitrofurantoin than E. faecalis. E. faecalis strains had a low prevalence of resistance to antibiotics used to treat E.

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Maake, Takalani Whitney, Olayinka Ayobami Aiyegoro, and Matthew Adekunle Adeleke. "Effects of Lactobacillus rhamnosus and Enterococcus faecalis Supplementation as Direct-Fed Microbials on Rumen Microbiota of Boer and Speckled Goat Breeds." Veterinary Sciences 8, no. 6 (2021): 103. http://dx.doi.org/10.3390/vetsci8060103.

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The effects on rumen microbial communities of direct-fed probiotics, Lactobacillus rhamnosus and Enterococcus faecalis, singly and in combination as feed supplements to both the Boer and Speckled goats were studied using the Illumina Miseq platform targeting the V3-V4 region of the 16S rRNA microbial genes from sampled rumen fluid. Thirty-six goats of both the Boer and Speckled were divided into five experimental groups: (T1) = diet + Lactobacillus rhamnosus; (T2) = diet + Enterococcus faecalis; (T3) = diet + Lactobacillus rhamnosus + Enterococcus faecalis; (T4, positive control) = diet + anti

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López-Jiménez, L., E. Fusté, B. Martínez-Garriga, J. Arnabat-Domínguez, T. Vinuesa, and M. Viñas. "Effects of photodynamic therapy on Enterococcus faecalis biofilms." Lasers in Medical Science 30, no. 5 (2015): 1519–26. http://dx.doi.org/10.1007/s10103-015-1749-y.

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Khodabandeh, Mahmoud, Mohsen Mohammadi, Mohammad Reza Abdolsalehi, et al. "High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; as a Serious Threat in Hospitals." Infectious Disorders - Drug Targets 20, no. 2 (2020): 223–28. http://dx.doi.org/10.2174/1871526519666181130095954.

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Aims and Objectives: The present work aimed to evaluate the frequency of aminoglycoside- modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic resistance profile. Methods: A total of 305 different clinical samples were subjected for identification and antibiotic susceptibility test. The high-level aminoglycoside resistance was identified by MIC and Kirby Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')- Ia genes was determined by multiplex- PCR. In total, 100 enterococci strains were isolated. The prevalence o

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