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1

Efthymia, Nikita, Xanthopoulou Panagiota, Bertsatos Andreas, Chovalopoulou Maria-Eleni, and Hafez Iosif. "A THREE-DIMENSIONAL DIGITAL MICROSCOPIC INVESTIGATION OF ENTHESEAL CHANGES AS SKELETAL ACTIVITY MARKERS." American Journal of Physical Anthropology 169, no. 4 (2019): 704–13. https://doi.org/10.1002/ajpa.23850.

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The current paper explores the effectiveness of entheseal changes as skeletal activity markers by testing the correlation between such changes and cross-sectional geometric (CSG) properties while controlling for the effect of age and body size. The originality of the paper lies in capturing entheseal changes in a continuous quantitative manner using 3D microscopy. Roughness and bone resorption were recorded on zone 1 and 2 of three humeral entheses (subscapularis, supraspinatus, infraspinatus) in a documented sample of 29 male skeletons. Our analysis found that merely 5.91% of the partial corr
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Naredo, Esperanza. "Power Doppler ultrasonography assessment of entheses in spondyloarthropathies: response to therapy of entheseal abnormalities." J Rheumatol 37, no. 10 (2010): 2110–7. https://doi.org/10.3899/jrheum.100136.

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Objective. To investigate the response to therapy of entheseal abnormalities assessed with power Doppler (PD) ultrasound (US) in spondyloarthropathies (SpA). Methods.Atotal of 327 patients with active SpA who were starting anti-tumor necrosis factor (TNF) therapy were prospectively recruited at 35 Spanish centers. A PDUS examination of 14 peripheral entheses was performed by the same investigator in each center at baseline and at 6 months. The following elementary lesions were assessed at each enthesis (presence/absence): morphologic abnormalities (hypoechogenicity and/or thickening), enthesea
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NAREDO, ESPERANZA, ENRIQUE BATLLE-GUALDA, M. LUZ GARCÍA-VIVAR, et al. "Power Doppler Ultrasonography Assessment of Entheses in Spondyloarthropathies: Response to Therapy of Entheseal Abnormalities." Journal of Rheumatology 37, no. 10 (2010): 2110–17. http://dx.doi.org/10.3899/jrheum.100136.

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Objective.To investigate the response to therapy of entheseal abnormalities assessed with power Doppler (PD) ultrasound (US) in spondyloarthropathies (SpA).Methods.A total of 327 patients with active SpA who were starting anti-tumor necrosis factor (TNF) therapy were prospectively recruited at 35 Spanish centers. A PDUS examination of 14 peripheral entheses was performed by the same investigator in each center at baseline and at 6 months. The following elementary lesions were assessed at each enthesis (presence/absence): morphologic abnormalities (hypoechogenicity and/or thickening), entheseal
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Henderson, C. Y., V. Mariotti, F. Santos, S. Villotte, and C. A. Wilczak. "The New Coimbra Method for Recording Entheseal Changes and the Effect of Age-at-Death." Bulletins et Mémoires de la Société d'Anthropologie de Paris 29, no. 3-4 (2017): 140–49. http://dx.doi.org/10.1007/s13219-017-0185-x.

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Entheseal changes have been widely used in anthropology to study activity patterns, but there is an increasing awareness that ageing is associated with these changes. The aim of this study was to test each feature of the new Coimbra method for its variability, side asymmetry and its relationship with age. In addition to this, an overall relationship with age was tested for a larger sample. Males 16 and over from the Coimbra skeletal collection of historically identified individuals were recorded using the new method (N = 260). To reduce the impact of occupation, side variability in asymmetry a
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Zhou, Q., J. Vadakekolathu, K. Sharif, et al. "THU0028 AN EXPLANTION FOR HOW VIRAL INFECTION MAY TRIGGER SPONDYLOARTHROPATHY BASED ON TLR9 DRIVEN TNF RESPONSES FROM ENTHESEAL DERIVED PLASMACYTOID DENDRITIC CELLS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 227–28. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5262.

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Background:It is well known that viral infections may trigger psoriatic arthritis (PsA), a disease that typically has extensive pre-clinical entheseal abnormalites. Skin resident plasmacytoid dendritic cells (pDCs) produce IFNα that contribute to T cell expansion and the development of experimental psoriasis [1, 2]. IFN pathway SNPs have been reported in both PsA and psoriasis and we previously reported the presence of pDCs at the human enthesis [3].Objectives:To investigate whether the TLR9 agonist ODN that replicates viral infection activate a wide array of of entheseal derived pDCs molecula
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Fagni, Filippo, Melek Yalcin Mutlu, Selahattin Alp Temiz, et al. "Tolerability of low to moderate biomechanical stress during leisure sport activity in patients with psoriasis and psoriatic arthritis." RMD Open 9, no. 4 (2023): e003612. http://dx.doi.org/10.1136/rmdopen-2023-003612.

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ObjectivesTo assess the impact of low to moderate biomechanical stress on entheses in patients with psoriasis and psoriatic arthritis (PsA).MethodsWe conducted a prospective interventional study on a cohort of psoriasis and PsA patients who underwent a 60 min badminton training session. Pain assessment by Visual Analogue Scale (VAS), physical examination of 29 entheses (SPARCC, LEI, MASES) and bilateral ultrasound at the lateral humeral epicondyle, inferior patellar pole and Achilles tendon were performed before and after training. Ultrasound changes were assessed using the OMERACT scoring sys
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Wink, Fréke, George A. Bruyn, Fiona Maas та ін. "Ultrasound Evaluation of the Entheses in Daily Clinical Practice during Tumor Necrosis Factor-α Blocking Therapy in Patients with Ankylosing Spondylitis". Journal of Rheumatology 44, № 5 (2017): 587–93. http://dx.doi.org/10.3899/jrheum.160584.

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Objective.To assess structural and inflammatory ultrasound (US) lesions of entheses in ankylosing spondylitis (AS) patients with active disease and to evaluate inflammatory lesions after 6 months of tumor necrosis factor (TNF-α) blocking therapy, in daily clinical practice.Methods.Consecutive patients with AS were clinically evaluated and underwent US examination of 9 bilateral entheses before and after 6 months of TNF-α blocking therapy. US examination included the following as inflammatory lesions: bone erosions/cortical irregularities, enthesophytes, calcifications as structural lesions; ad
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8

Schrader, Sarah A., and Michele R. Buzon. "Everyday Life after Collapse: A Bioarchaeological Examination of Entheseal Change and Accidental Injury in Postcolonial Nubia." Bioarchaeology International 1, no. 1–2 (2017): 19–34. http://dx.doi.org/10.5744/bi.2017.1000.

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Palmer, Jessica L. A., and Andrea L. Waters‐Rist. "Acts of life: Assessing entheseal change as an indicator of social differentiation in postmedieval Aalst ( Belgium )." International Journal of Osteoarchaeology 29, no. 2 (2019): 303–13. http://dx.doi.org/10.1002/oa.2740.

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Henderson, C. Y. "Do diseases cause entheseal changes at fibrous entheses?" International Journal of Paleopathology 3, no. 1 (2013): 64–69. http://dx.doi.org/10.1016/j.ijpp.2013.03.007.

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11

Myszka, Anna, Janusz Piontek, Jacek Tomczyk, and Marta Zalewska. "Osteoarthritis – a problematic skeletal trait in past human populations. Osteoarthritic changes vs. entheseal changes in the late medieval and early modern population form Łekno." Anthropological Review 83, no. 2 (2020): 143–61. http://dx.doi.org/10.2478/anre-2020-0011.

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AbstractAccording to medical knowledge, physical activity plays a role in osteoarthritic changes formation. The impact of occupation on osteoarthritic changes development in past human populations is not clear enough, causing problems with interpretation. The aim of the current study is to examine the relationship between osteoarthritis and entheseal changes. Skeletal material comes from the late medieval, early modern population from Łekno (Poland). The sample consists of 110 males and 56 females (adults only). Osteophytes, porosity and eburnation were analyzed in the shoulder, elbow, wrist,
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Kaeley, Gurjit S. "Enthesitis in psoriatic arthritis (Part 2): imaging." Rheumatology 59, Supplement_1 (2020): i15—i20. http://dx.doi.org/10.1093/rheumatology/keaa040.

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Abstract Enthesitis is a hallmark finding in PsA and may predate the onset of synovitis. Clinical examination of enthesitis provides no structural information, relies on eliciting tenderness at entheseal sites and may not be sensitive or specific. Soft tissue imaging techniques such as musculoskeletal ultrasound and MRI can depict ultrastructural and inflammatory changes. Although these imaging techniques are complimentary, ultrasound can image superficial entheses with high fidelity and examine vascularity with the use of Doppler but cannot image subchondral bone. MRI depicts bone and can vis
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Mathew, Ashish J., Simon Krabbe, Iris Eshed, et al. "The OMERACT MRI in Enthesitis Initiative: Definitions of Key Pathologies, Suggested MRI Sequences, and a Novel Heel Enthesitis Scoring System." Journal of Rheumatology 46, no. 9 (2019): 1232–38. http://dx.doi.org/10.3899/jrheum.181093.

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Objective.To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model.Methods.Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration.Results.Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiolog
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Rossi-Semerano, L., V. Ravagnani, P. Collado, et al. "AB1447 VALIDITY OF ULTRASONOGRAPHY IN DETECTING ENTHESITIS IN CHILDREN: A SYSTEMATIC LITERATURE REVIEW." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1952.1–1952. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3653.

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BackgroundSeveral studies have suggested a potential role for ultrasonography (US) in detecting enthesitis in children, thus enhancing the accuracy of the classification of juvenile idiopathic arthritis (JIA) and improving the therapeutic approach. Because of no consensual definition of ultrasonographic enthesitis in children, the pediatric sub-taskforce of the OMERACT working group posed the research question of whether there are sufficient data to support the role of US in the diagnosis and follow-up of enthesitis in JIA, particularly enthesitis related arthritis (ERA).ObjectivesWe performed
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Tinazzi, I., G. Citriniti, N. Girolimetto, et al. "SAT0400 EVIDENCE FOR “DEEP KOEBNERISATION” AT BOTH THE ENTHESIS AND VASCULAR BIFURCATIONS AS A NOVEL MECHANISTIC LINK BETWEEN PSORIATIC ARTHRITIS AND CARDIOVASCULAR DISEASE- RESULTS OF PILOT ULTRASOUND STUDIES OF JOINTS AND ARTERIES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1151. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6362.

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Background:The association between PsA and cardiovascular disease is generally thought to be greater than the risk between psoriasis and cardiovascular disease. Vascular calcifications (VC) are considered an early marker of atherogenesis and accurate VC scores including Carotid, Aortic and Lower limbs vascular Calcifications (CALC) were published2. PsA localises to entheses that are sites of high physical stressing, analogous to artery bifurcations which are sites of high vascular stress. Entheseal calcification is a feature of the post-inflammatory changes. We hypothesised that there may be c
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Bakirci, Sibel, Dilek Solmaz, Wilson Stephenson, Lihi Eder, Johannes Roth, and Sibel Zehra Aydin. "Entheseal Changes in Response to Age, Body Mass Index, and Physical Activity: An Ultrasound Study in Healthy People." Journal of Rheumatology 47, no. 7 (2020): 968–72. http://dx.doi.org/10.3899/jrheum.190540.

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Objective.We aimed to investigate the prevalence of ultrasonographic (US) lesions in healthy entheses and contributing factors.Methods.US scans were performed on 960 entheses of 80 healthy subjects. Factors contributing to entheseal changes were investigated with regression analysis.Results.Thickening (20.4% of the entheses) and enthesophytes (23.1%) were the most common inflammatory and structural damage lesions, respectively. Age (p < 0.001), male sex (p = 0.003), body mass index (BMI; p = 0.001), and high physical activity (p = 0.007) were independent predictors of enthesitis scores on U
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Bertsatos, Andreas, Maria-Eleni Chovalopoulou, Nikoletta-Maria Boskovits, Nefeli Garoufi, and Efthymia Nikita. "The impact of activity on pelvic age-at-death estimation." International Journal of Osteoarchaeology 31, no. 2 (2020): 218–31. https://doi.org/10.1002/oa.2941.

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This study assesses whether greater levels of physical activity result in increased rates of degenerative change in the pubic symphysis and the iliac auricular surface. The sample comprises 131 skeletons from the Athens Collection. Skeletal age-at-death was estimated from the pubic symphysis and the iliac auricular surface. Skeletal activity was assessed using femoral cross-sectional geometric (CSG) properties and fibrocartilaginous entheses. The association between skeletal age stages, CSG properties and entheseal changes (EC) was tested using Spearman correlation followed with partial Spearm
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Binks, D., D. Bergin, A. Hindley, D. McGonagle, and A. Radjenovic. "THU0029 Anatomical variation in the morphology of the posterior cruciate ligament synovio-entheseal complex and correlation with degenerative change." Annals of the Rheumatic Diseases 71, Suppl 3 (2013): 163.1–163. http://dx.doi.org/10.1136/annrheumdis-2012-eular.1994.

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Palmer, J. L. A., K. Quintelier, S. Inskip, and A. L. Waters-Rist. "A Comparison of Two Methods for Recording Entheseal Change on a Post-Medieval Urban Skeletal Collection from Aalst (Belgium)." Archaeometry 61, no. 1 (2018): 211–25. http://dx.doi.org/10.1111/arcm.12409.

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Marchesoni, Antonio, Pierluigi Macchioni, Stefania Gasparini, et al. "Use of Ultrasonography to Discriminate Psoriatic Arthritis from Fibromyalgia: A Post-Hoc Analysis of the ULISSE Study." Journal of Clinical Medicine 11, no. 1 (2021): 180. http://dx.doi.org/10.3390/jcm11010180.

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In psoriatic arthritis (PsA) patients with concomitant chronic widespread pain, the differential diagnosis with fibromyalgia syndrome (FMS) can be challenging. We evaluated whether ultrasound (US) examination of entheseal sites can distinguish pain from (PsA) enthesitis versus FMS. PsA and FMS patients underwent clinical evaluation and gray-scale (GS; B-mode) and power Doppler (PD) US examination of the entheses. At least one enthesis with GS- and PD-mode changes was found in 90% and 59.3% of PsA patients (n = 140) and 62.7% and 35.3% of FMS patients (n = 51), respectively. GS and PD identifie
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Holt, Vance E., Yongquan Luo, and Robert A. Colbert. "IL-22 Effects on Osteoblast Mineralization and Metabolic Profile." Journal of Immunology 204, no. 1_Supplement (2020): 73.7. http://dx.doi.org/10.4049/jimmunol.204.supp.73.7.

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Abstract Ankylosing spondylitis (AS) is an immune-mediated inflammatory disease characterized by persistent entheseal inflammation and aberrant bone formation that can lead to vertebral fusion. The Type 17 cytokine IL-17 and IL-10 family member IL-22 are involved in pathogenesis. Moreover, IL-22 has been implicated in aberrant bone formation, but its precise role remains unclear. Mesenchymal stem cells (MSCs) differentiate into osteoblasts (OBs) and are believed to reside near entheseal tissues and contribute to the observed bone formation. They express the IL-22 receptor after commitment to t
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Bucchi, Ana, María Cristina Manzanares, Javier Luengo, Cristina Bucchi, and Carlos Lorenzo. "Muscle strength and entheseal size in human thumbs: testing the relationship with a cadaveric model." Journal of the International Union of Prehistoric and Protohistoric Sciences 2, no. 2 (2019): 38–42. http://dx.doi.org/10.62526/nxwc7e.

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In this study we analyse the relationship between strength and the entheseal area of the opponens pollicis (OP) and abductor pollicis longus (APL) muscles, two muscles of the hand whose main function is to oppose the thumb and move the thumb anteriorly, respectively. We were interested in this link for two reasons: (1) to determine if muscular strength is related to entheseal size, and (2) to evaluate the predictive power of enthesis, age, sex and body size on muscular strength. With the latter objective we attempt to discuss whether it is reasonable to infer behaviour from entheses in the arc
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Đukić, Ksenija, Petar Milovanović, Petar Milenković, and Marija Đurić. "A microarchitectural assessment of the gluteal tuberosity suggests two possible patterns in entheseal changes." Am J Phys Anthropol 172, no. 2 (2020): 291–99. https://doi.org/10.1002/ajpa.24038.

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Objectives. Macroscopic entheseal forms show two main features: predominant signs of bony formation or resorption. To understand the development of these forms, we investigated microarchitectural differences between the macroscopic proliferative and resorptive forms of the gluteus maximus enthesis. Materials and Methods. The macromorphological analysis of entheseal changes (EC) was based on the Villotte, visual scoring system for fibrous entheses. Gluteal tuberosity specimens of different stages of Villote's system were harvested from 16 adult males derived from an archaeolo
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Falsetti, P., E. Conticini, C. Baldi, et al. "THU0520 DIFFUSE ENTHESITIS AND LOW-GRADE INFLAMMATION IN PATIENTS WITH METABOLIC SYNDROME: A CLINICAL AND ULTRASOUND STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 499.1–499. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4550.

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Background:Metabolic syndrome (MS) is a clinical condition characterized by central obesity and additional factors such dyslipidemia, hypertension, raised fasting plasma. Scanty observations describe the association of MS with musculoskeletal conditions, such as enthesopathies and diffuse idiopathic hyperostosis syndrome (DISH). Musculoskeletal ultrasound (US) has been applied to the study of entheses, but the real prevalence and characteristics of entheseal involvement in MS has yet to be clarified.Objectives:The aim of our work was to study the US-defined entheseal changes in MS, to correlat
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Fairushina, I. F., E. R. Kirillova, D. I. Abdulganieva, E. V. Sukhorukova, and E. I. Mukhametshina. "Psoriatic arthritis: clinical and ultrasound parallels." Modern Rheumatology Journal 14, no. 3 (2020): 27–33. http://dx.doi.org/10.14412/1996-7012-2020-3-27-33.

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Objective: to assess the relationship of the clinical characteristics and laboratory inflammatory markers to the ultrasound signs of synovitis and enthesitis in patients with psoriatic arthritis (PsA).Patients and methods. Examinations were made in 63 patients diagnosed with PsA according to the 2006 Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. Among the patients, the majority were females (54.2%); the mean age was 42.9±10.3 years; the median (Me) PsA duration was 7 [3; 10] years; Me Disease Activity in Psoriatic Arthritis (DAPSA) was 16.5 [11.6; 25] years.All the patient
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Binks, D. A., E. M. Gravallese, D. Bergin, et al. "Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis." Annals of the Rheumatic Diseases 74, no. 1 (2013): 196–203. http://dx.doi.org/10.1136/annrheumdis-2013-203972.

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ObjectivesThe purpose of this work was to test whether normal peri-entheseal vascular anatomy at anterior and posterior cruciate ligaments (ACL and PCL) was associated with distribution of peri-entheseal bone erosion/bone marrow lesions (BMLs) in inflammatory arthritis (IA) and osteoarthritis (OA).MethodsNormal microanatomy was defined histologically in mice and by 3 T MRI and histology in 21 cadaveric knees. MRI of 89 patients from the Osteoarthritis Initiative and 27 patients with IA was evaluated for BMLs at ACL and PCL entheses. Antigen-induced arthritis (AIA) in mice was evaluated to asce
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Henderson, C. Y., V. Mariotti, D. Pany-Kucera, S. Villotte, and C. Wilczak. "Recording Specific Entheseal Changes of Fibrocartilaginous Entheses: Initial Tests Using the Coimbra Method." International Journal of Osteoarchaeology 23, no. 2 (2012): 152–62. http://dx.doi.org/10.1002/oa.2287.

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Pacheco-Tena, César, Ruy Pérez-Tamayo, Carlos Pineda, et al. "Bone Lineage Proteins in the Entheses of the Midfoot in Patients with Spondyloarthritis." Journal of Rheumatology 42, no. 4 (2014): 630–37. http://dx.doi.org/10.3899/jrheum.140218.

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Objective.Patients with juvenile-onset spondyloarthritis (SpA) may develop ankylosis of the midfoot resembling the spinal changes seen in patients with ankylosing spondylitis (AS). The study of the histopathology of the feet of patients with tarsitis could help us understand the pathogenesis of bone formation in affected structures in the SpA. The objective of our study was to describe the histopathologic characteristics of the midfoot in patients with tarsitis associated with SpA.Methods.We obtained synovial sheaths, entheses, and bone samples from 20 patients with SpA with midfoot pain/tende
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Boussaid, S., R. Ben Aissa, S. Rekik, et al. "AB0951 Entheseal involvement in healthy subjects: What can lower limb ultrasonography tell us?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1603.2–1604. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4127.

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BackgroundOver the past few years, ultrasonography (US) has been a very useful tool in the detection of subclinical enthesopathy especially in spondyloarthritis patients. However, could US entheseal involvement detection by US in healthy subjects be predictive of evolution to an inflammatory rheumatic disease?ObjectivesTo identify by US the prevalence of entheseal abnormalities at the lower limb of healthy subjects and associated risk factors.MethodsUS assessment was performed on 400 entheses of 40 healthy volunteer subjects along with clinical examination. Exclusion criteria: Enthesitis on th
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Krabbe, Simon, Mikkel Østergaard, Iris Eshed, et al. "Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab." Journal of Rheumatology 45, no. 5 (2018): 621–29. http://dx.doi.org/10.3899/jrheum.170408.

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Objective.To investigate whether adalimumab (ADA) reduces whole-body (WB-) magnetic resonance imaging (MRI) indices for inflammation in the entheses, peripheral joints, sacroiliac joints, spine, and the entire body in patients with axial spondyloarthritis (axSpA).Methods.An investigator-initiated, randomized, placebo-controlled, double-blinded 48-week followup trial included 49 patients with axSpA, who had Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4.0 despite treatment with nonsteroidal antiinflammatory drugs and a clinical indication for tumor necrosis factor inhibitor tre
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Shuler, K. A., P. Zeng, and M. E. Danforth. "Upper limb entheseal change with the transition to agriculture in the southeastern United States: A view from Moundville and the central Tombigbee River valley." HOMO 63, no. 6 (2012): 413–34. http://dx.doi.org/10.1016/j.jchb.2012.09.002.

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Lambi, Alex G., Robert J. DeSante, Parth R. Patel, Brendan A. Hilliard, Steven N. Popoff, and Mary F. Barbe. "Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury." International Journal of Molecular Sciences 24, no. 18 (2023): 13866. http://dx.doi.org/10.3390/ijms241813866.

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The matricellular protein cell communication factor 2/connective tissue growth factor (CCN2/CTGF) is critical to development of neuromuscular fibrosis. Here, we tested whether anti-CCN2 antibody treatment will reduce established forepaw fibro-degenerative changes and improve function in a rat model of overuse injury. Adult female rats performed a high repetition high force (HRHF) task for 18 weeks. Tissues were collected from one subset after 18 wks (HRHF-Untreated). Two subsets were provided 6 wks of rest with concurrent treatment with anti-CCN2 (HRHF-Rest/anti-CCN2) or IgG (HRHF-Rest/IgG). R
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Wetterslev, M., W. P. Maksymowych, R. G. Lambert, et al. "OP0149 RELIABILITY AND RESPONSIVENESS OF TWO OMERACT WHOLE-BODY MRI SCORES OF ENTHESEAL AND JOINT INFLAMMATION IN THE KNEE REGION IN SPONDYLOARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 89–90. http://dx.doi.org/10.1136/annrheumdis-2021-eular.755.

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Background:Inflammation in peripheral joints and entheses is common in spondyloarthritis (SpA). Whole-body magnetic resonance imaging (WB-MRI) allows assessment of the overall inflammatory status of arthritis patients including joints and entheses. The OMERACT MRI Whole-body scoring system for Inflammation in Peripheral joints and Entheses (MRI-WIPE) [1] has been developed and validated for the entire body assessment, including the knee, but not separately validated for the knee joint region. Detailed MRI scoring systems exist for heels, hands and feet, but although knee arthritis is a key cau
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Hull, Emily H. "Metric and non-metric guides for the determination between fore- and hindlimb phalanges of Rangifer tarandus." Rangifer 39, no. 1 (2019): 11–26. http://dx.doi.org/10.7557/2.39.1.4630.

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Phalanges are a great untapped resource in the zooarchaeology of Rangifer tarandus. The utilization of this resource, however, is constrained by a current inability to consistently differentiate fore- from hindlimb phalanges in a mixed assemblage. The ability to separate and identify forelimb and hindlimb phalanx 1 (PI) and phalanx 2 (PII), as well as to recognize and identify other small bones of the hoof, leads to great opportunities for archaeologists. In large scale-analysis, this capacity allows a greater ability to determine minimum number of individuals and assess butchery and transport
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Schreiner, J. K., F. Recker, D. Scheicht, et al. "POS1387 ULTRASOUND FINDINGS OF JOINTS AND ENTHESES FOLLOWING ONE HOUR OF AGE AND GENDER ADJUSTED WEIGHT TRAINING." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1033.2–1034. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1751.

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BackgroundJoint effusion and enthesitis are common ultrasound findings in rheumatologic diseases like rheumatoid arthritis or spondyloarthritis. Physically active individuals and athletes were also found to exhibit structural and vascular changes in their entheses, as well as joint effusion through different imaging approaches [1, 2].ObjectivesThe aim of this study was to evaluate the development of joint and entheseal ultrasound findings in large and medium joints of young healthy individuals after one hour of standardised weight training.MethodsA total of three musculoskeletal ultrasound exa
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Sick, Jess. "Entheseal Changes: Benefits, Limitations and Applications in Bioarchaeology." Pathways 2, no. 1 (2021): 14–35. http://dx.doi.org/10.29173/pathways25.

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Reconstructing physical activities in ancient humans has long been pursued in bioarchaeology to understand our history and development. Entheseal changes (EC)––variations to muscle, tendon, and ligament attachment sites on bone––have been used in bioarchaeology since the 1980s to reconstruct activities in past populations such as changes in mobility, subsistence strategy, and gendered division of labour. EC research is based on bone functional adaptation, where bone responds to mechanical stress on entheses through bone formation or destruction in varying degrees of expression. However, the re
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Coates, L. C., J. Fransen, and P. S. Helliwell. "Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment." Annals of the Rheumatic Diseases 69, no. 01 (2009): 48–53. http://dx.doi.org/10.1136/ard.2008.102053.

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Objective:To create minimal disease activity (MDA) criteria for psoriatic arthritis (PsA). With recent therapeutic advances, this is now a goal for treatment and may represent a measure to compare therapies. It defines a satisfactory state of disease activity rather than a change, and encompasses all aspects of the disease.Methods:40 patient profiles were sampled from an observational PsA database. Sixty experts in PsA classified these as in MDA or not. A consensus of ⩾70% was accepted, identifying 13 profiles in MDA. Summary statistics created possible cut-off points for the definition. Consi
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Patel, Parth R., Istvan P. Tamas, Megan Van Der Bas, et al. "Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats." International Journal of Molecular Sciences 25, no. 24 (2024): 13546. https://doi.org/10.3390/ijms252413546.

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Overuse injury is a frequent diagnosis in occupational medicine and athletics. Using an established model of upper extremity overuse, we sought to characterize changes occurring in the forepaws and forelimbs of mature female rats (14–18 months of age). Thirty-three rats underwent a 4-week shaping period, before performing a high-repetition low-force (HRLF) task for 12 weeks, with the results being compared to 32 mature controls. HRLF animals showed a reduced grip strength versus controls. ELISAs carried out in the HRLF rats, versus controls, showed elevated levels of IL1-α in tendons, IL1-α an
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Fairushina, I., E. Kirillova, and D. Abdulganieva. "POS1098 DO THE CHANGES DETECTED BY ULTRASOUND AFFECT THE QUALITY OF LIFE OF YOUNG AND MIDDLE-AGED PATIENTS WITH PSORIATIC ARTHRITIS?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 876.2–877. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4747.

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BackgroundThe quality of life (QoL) is included in the main domain for psoriatic arthritis (PsA) course assessment.1 In the last years, the role of imaging has grown up. The European League Against Rheumatism recognized that ultrasound (US) has higher sensitivity than clinical examination to detect inflammatory disease activity. The data showing the association between (b/w) QoL and US changes in PsA is limited.ObjectivesTo study relationship b/w US articular and entheseal involvement and QoL in PsA.Methods18-60-aged patients (n=92) were enrolled to study with fulfilled PsA criteria (CASPAR, 2
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Citriniti, G., P. Macchioni, N. Girolimetto, L. Cimino, and C. Salvarani. "SAT0545 ULTRASONOGRAPHIC ENTHESEAL AND JOINT INVOLVEMENT IN PATIENTS WITH ACUTE ANTERIOR UVEITIS: A MONOCENTRIC CROSS-SECTIONAL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1229.2–1230. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6392.

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Background:Few studies have been investigating ultrasonographic (US) changes at peripheral entheses and joints in patients with anterior acute uveitis (AAU)1and none has been comparing non granulomatous uveitis (AANGU) with granulomatous uveitis (AAGU).Objectives:To investigate prevalence of US entheses and joints abnormalities in a consecutive series of AAU patients and to compare US findings in AANGU HLA-B27 positive and HLA-B27 negative, with AAGU patients.Methods:121 consecutive patients diagnosed with AAU [91 AANGU (40 B27-, 61 B27+) and 20 AAGU, M/F 32/29, mean age 45.4± 12.8 y, mean dis
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Henderson, C. "Subsistence strategy changes: The evidence of entheseal changes." HOMO 64, no. 6 (2013): 491–508. http://dx.doi.org/10.1016/j.jchb.2013.08.002.

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Villotte, S., and C. J. Knüsel. "Understanding Entheseal Changes: Definition and Life Course Changes." International Journal of Osteoarchaeology 23, no. 2 (2012): 135–46. http://dx.doi.org/10.1002/oa.2289.

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Lackner, Angelika, Daniel Heber, Philipp Bosch, et al. "Ultrasound verified enthesophytes are associated with radiographic progression at entheses in psoriatic arthritis." Rheumatology 59, no. 10 (2020): 2893–97. http://dx.doi.org/10.1093/rheumatology/keaa028.

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Abstract Objectives The aim of this prospective study was to examine whether ultrasound or clinical abnormalities at enthesal sites predict radiographic progression at entheses in psoriatic arthritis (PsA). Methods Consecutive PsA patients were included and subjected to clinical and ultrasound assessments at 14 entheses at baseline, 6 and 12 months. Radiographs were performed at 0 and 12 months. By US, we investigated structural (erosions, osteophytes) and inflammatory changes [grey scale (0–32) and power Doppler (0–14, range global ultrasound score 0–140)], and radiographs were evaluated for
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Albee, Malorie E. "Take a load off: skeletal implications of sedentism in the feet of modern body donors." Evolution, Medicine, and Public Health 11, no. 1 (2023): 485–501. http://dx.doi.org/10.1093/emph/eoad041.

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Abstract Background and Objectives Modern biocultural environments continue to place selective pressures on our skeletons. In the past century, a major cultural pressure has been the rise in sedentism. However, studies considering the effects of sedentism on the foot have largely considered pathological changes to the gross foot without particular regard for the pedal skeleton. To address this gap in the literature, temporal trends in the development of osteoarthritis and entheseal changes on the tarsals and metatarsals were analyzed in the context of biodemographic data for recent modern huma
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Danasasmita, Gantira, Anna Ariane, and Rudy Hidayat. "Axial Spondyloarthritis Unresponsive to Secukinumab, an IL-17A Inhibitor Therapy, a Case Report." Journal of Clinical Rheumatology and Immunology 24, supp01 (2024): 20–21. http://dx.doi.org/10.1142/s2661341724740201.

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Introduction Axial spondyloarthritis (axSpA) is a group of autoinflammatory disease that hypothetically caused by tumor necrosis factor (TNF) axis and interleukin (IL)-23/IL-17 axis. Based on algorithm of treatment from ASAS/EULAR 2022, biologic agent is indicated if patient did not response to NSAIDs, the first line treatment. TNF inhibitor and IL-17 inhibitor are two biologic agent that has been approved and gave significant result in improving disease activity. Case Description A 47 years old woman who has been diagnosed with axSpA since 2022. At first she was given medication with NSAIDs.
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Guillén-Astete, C., M. Tortosa-Cabañas, and Á. Andreu-Suárez. "AB1381 DETECTION OF QUANTITATIVE ULTRASOUND CHANGES AFTER CORTICOID INFILTRATION OF THE PREACHILLEAL BURSA IN PATIENTS WITH INFLAMMATORY OR MECHANICAL ENTHESOPATHIES." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1795.2–1796. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5136.

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BackgroundIt has recently been demonstrated that computer analysis of static ultrasound images can detect exercise-induced stromal changes in the body’s load-bearing tendons.ObjectivesThe purpose of this study is to determine if the same analysis can detect enthesic changes in patients who have undergone corticosteroid infiltration in the preachilles bursa.MethodsSerial images of patients who received corticosteroid injections (around 40mg of triamcinolone acetonide) in the preachilles bursa were selected. For the records to be considered it was necessary at least one baseline ultrasound study
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Weiss, Elizabeth. "The surface of bones: methods of recording entheseal changes." Surface Topography: Metrology and Properties 3, no. 3 (2015): 034003. http://dx.doi.org/10.1088/2051-672x/3/3/034003.

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Villotte, Sébastien, Sandra Assis, Francisca Alves Cardoso, et al. "In search of consensus: Terminology for entheseal changes (EC)." International Journal of Paleopathology 13 (June 2016): 49–55. http://dx.doi.org/10.1016/j.ijpp.2016.01.003.

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Salmi, Anna-Kaisa, Sirpa Niinimäki, and Tuula Pudas. "Identification of working reindeer using palaeopathology and entheseal changes." International Journal of Paleopathology 30 (September 2020): 57–67. http://dx.doi.org/10.1016/j.ijpp.2020.02.001.

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EMAD, YASSER, YASSER RAGAB, IMAN BASSYOUNI, et al. "Enthesitis and Related Changes in the Knees in Seronegative Spondyloarthropathies and Skin Psoriasis: Magnetic Resonance Imaging Case-Control Study." Journal of Rheumatology 37, no. 8 (2010): 1709–17. http://dx.doi.org/10.3899/jrheum.100068.

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Objective.To describe enhanced magnetic resonance imaging (MRI) features and characteristic entheseal changes in the knees in patients with seronegative spondyloarthropathy (SpA).Methods.The 56 patients included 30 with psoriatic arthritis, 5 with ankylosing spondylitis, 5 with reactive arthritis, 5 with ulcerative colitis (UC), 5 with Crohn’s disease, and another 6 with skin psoriasis. Controls were 20 healthy subjects without knee complaints. MRI was performed in all participants, emphasizing entheseal sites.Results.Both knees were studied in 45 (80.3%) patients and one knee in 11 (19.6%). M
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