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Dissertations / Theses on the topic 'ENU'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Shaw, Linda Marie. "Characterisation of ENU-induced circadian mutants." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497452.

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2

Michel, Dian. "Implementation and optimization of a large-scale ENU mouse mutagenesis screen and characterisation of five ENU-induced limb mutant lines." kostenfrei, 2009. http://mediatum2.ub.tum.de/node?id=737365.

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3

Ishikawa, Yuji, Yasuko Hyodo-Taguchi, Kazuko Aoki, Takako Yasuda, Atsuko Matsumoto, and Motoe Sasanuma. "INDUCTION OF MUTATIONS BY ENU IN THE MEDAKA GERMLINE." Laboratory of Freshwater Fish Stocks Bioscience Center Nagoya University, 1999. http://hdl.handle.net/2237/13825.

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4

Eddy, Jessica B. "Effects of ENU mutations of Zfp804a on behavioural phenotypes." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/57955/.

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Genetic variation in the gene ZNF804A has been shown to be related to risk for psychopathology, especially schizophrenia and bipolar disorder. The main aim of this thesis was to characterise the behavioural effects of Zfp804a, the mouse orthologue of ZNF804A, in order to understand more about how this gene influences brain and psychological functioning, and hence provide clues as to its possible role in mediating risk for mental disorders. Prior to this work, two ENU-mutant mouse lines had been generated from a DNA library of ENU mutagenised mice with two non-synonymous mutations selected as v

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5

Curtin, John Anthony. "Genetic characterisation of spin cycle : an ENU induced mutant mouse." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400468.

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6

Anstee, Quentin Mark. "ENU mutagenesis and mouse models of steatosis, steatohepatitis and fibrosis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7841.

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7

Binder, Elke. "Charakterisierung und Validierung von ENU-Mausvarianten mit beeinträchtigter Fähigkeit zur Objekterkennung." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-20927.

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8

Nijnik, A. "ENU mouse mutant with a hypomorphic mutation in DNA ligase IV." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:5a8ae151-6261-4ad4-9541-d5c59ba654a7.

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9

Keays, David. "The identification and characterisation of novel ENU induced behavioural mouse mutants." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424721.

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10

Edwards, Andrew. "Neuroanatomical screening and analysis of transgenic and ENU induced mutagenised mice." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:1ca62d53-e801-49be-959b-99f7092ad9fb.

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I have sought to discover genetic causes of neuroanatomical defects by conducting N-ethyl-N-nitrosourea mutagenesis and transgenic knock out screens in mice. The rationale behind this is that mutations causal to structural defects will be informative about developmental neurobiology and the biological basis of behaviour. Direct screening for behavioural abnormalities in mice has historically been arduous and yielded few findings due to small effect sizes and limited statistical power. My approach sought to bypass these problems by screening for highly penetrant morphological phenotypes. This t

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11

Romao, P. L. "Mapping ENU-induced thymic lymphoma susceptibility loci in C57BL/6 mice." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47379/.

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Tumour development is a complex process involving susceptibility loci (oncogenes) and the accumulation of spontaneous somatic mutations in tumour suppressor genes that interact to result in cancer. Tumours may require the accumulation of a variety of mutations before developing but the general principle is that the mutations result in an imbalance between the oncogene and tumour suppressor gene function (Berger et al., 2011). This multi-hit process can be tested by subjecting strains of mice susceptible to certain types of tumours to chemical mutagens, thereby inducing further mutations. This

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12

Meyer, Carola. "Phänotypische und stoffwechselphysiologische Charakterisierung von ENU-(Ethylnitrosoharnstoff-)induzierten Mausmutanten mit gestörter Körpergewichtsregulation." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0112/.

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13

Klaften, Matthias. "Ein neuartiges Konzept zur genomweiten Kartierung von ENU-induzierten Mausmutanten im Hochdurchsatz." kostenfrei, 2007. http://mediatum2.ub.tum.de/doc/620272/document.pdf.

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14

Kaur, Kulvinder. "Molecular characterisation of mouse lines containing ENU induced recessive mutations on chromosome 13." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526471.

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15

Rhodes, Charlotte R. "Characterisation of new ENU induced mouse models of genetic deafness and vestibular function." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250534.

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16

Chessum, Lauren. "Characterisation of cello : an ENU-induced mouse model of early-onset hearing loss." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:0179f404-3426-4ca3-a04b-6dedab72c507.

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cello is a recessive mouse model of early-onset, sensorineural hearing loss that was identified from a large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis screen undertaken at MRC Harwell. Linkage analysis and whole-genome sequencing identified that cello mice have a non-synonymous point mutation in Ikaros family zinc finger 2 (Ikzf2), which encodes a zinc finger transcription factor called helios. To investigate the role of helios in the auditory system, cello mice underwent comprehensive molecular, phenotypic and functional characterisation. The cello mutation was found to disrupt a highly c

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17

Lisse, Thomas Stephen. "Identifizierung, Genkartierung, und Charakterisierung von ENU-induzierten mutanten Mauslinien für Knochenkrankheiten des Menschen." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34513.

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18

Kildey, Katrina Mona Alicia. "Genetic studies of red blood cell differentiation and stability: ENU-induced murine mutations." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/95377/1/Katrina_Kildey_Thesis.pdf.

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In this study, genetic changes that modify red blood cell development and lifespan were investigated in several different mouse models. A key original finding was a previously unknown genetic change in a sugar-modifying enzyme, which results in loss of a marker only found on mature red blood cells. Several genetically defined changes in red cell structural proteins that impact on the storage life of red cells were also explored. This application of genetic tools provided an improved understanding of red blood cell differentiation and factors that impact on red blood cell stability during stora

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19

Kumar, Sudhir. "Molecular genetic and phenotypic analysis of ENU-induced mutant mouse models for biomedical research." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-134175.

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20

Brown, Sarah Mills. "Genome wide gene expression analysis of two ENU mouse models of major mental illness." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5541.

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Major mental illness is now recognised as one of the leading causes of adult morbidity. Of the adult onset psychiatric disorders, the functional psychoses (schizophrenia, bipolar disorder and recurrent major depression) are the most severe and most common in the general population. Evidence suggests that certain genetic factors influence an individual’s susceptibility to developing these disorders when combined with appropriate social and environmental conditions. Several good candidate genes have been identified. Of relevance to this study is Disrupted in Schizophrenia 1 (DISC1) which was ide

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21

Howaldt, Maike Susanne. "Phänotypische und genotypische Charakterisierung der ENU-induzierten Mausmutante SMA002 als Tiermodell für Wachstumsdefizit und Hyperaktivität." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-19293.

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22

Tran, Van Tuyen. "Phänotypische und genotypische Charakterisierung der ENU-induzierten Mausmutante HST001 zur Verwendung für die nephrologische Forschung." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-22579.

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23

De, Sao Jose Martinho De Oliveira Hugo. "Investigating TDP43 biological dysfunction through the characterisation of Tardbp ENU mouse mutants : implications for neurodegeneration." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:76734577-f754-4dfa-bdf1-c6547abd8a5e.

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24

Agnew, Thomas. "Characterisation of a novel mouse model of mitochondrial disease : a hypomorphic Wars2 ENU-induced allele." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:7d7be93e-052d-4c6b-98cb-9aae257a4e42.

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Mitochondrial aminoacyl-tRNA synthetases (mtRS) are vital for mitochondrial translation. mtRSs catalyse the aminoacylation of mitochondrial tRNA with their cognate amino acid. Mutations in mtRS genes are associated with distinct clinical pathologies in humans. Studying mtRS mutations in model organisms is difficult because mtRS knock-out alleles are haplosufficient and cause embryonic lethality in their homozygous state. In this study, we phenotypically and mechanistically characterised a hypomorphic, ENU-induced Wars2 allele (Wars2-V117L) in mouse with the aim to determine the cause of the ti

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25

Pieles, Guido. "Studying the Origins of Congenital heart disease Using ENU Mutagenesis and Micro Magnetic Resonance Imaging (uMRI)." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504451.

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26

Hobbs, Eleanor. "Investigation of candidate risk genes for neuropsychiatric disease in vitro and in vivo using ENU mutagenesis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:6204220c-3680-4549-8399-872c6dd4b473.

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Schizophrenia is a complex mental disorder characterised by positive symptoms such as hallucinations and psychosis, negative symptoms such as avolition and anhedonia, and cognitive defects. Schizophrenia risk has a genetic component, and it is likely that this is caused by interaction between numerous genes with individually small effects. Environment also plays a role; factors associated with schizophrenia include drug use, prenatal stressors and living environment. Candidate genes linked to schizophrenia have been identified through recent GWAS of human populations with the disorder, includi

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27

Bürck, Lelia van. "Clinical and pathomorphological characterisation of two diabetic mouse models derived from the Munich ENU mouse mutagenesis project." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-130293.

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28

Prückl, Petra Christine. "Untersuchung zweier ENU-induzierter mutanter Mauslinien mit Fokus auf eine Linie mit einer Punktmutation im Uromodulin-Gen." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-131358.

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29

Coogan, Christian P. "Reduced fidelity of E. coli leading strand DNA replication opposite ENU-induced thymine adducts in the transcribed strand /." Available to subscribers only, 2005. http://proquest.umi.com/pqdweb?did=1079660821&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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30

Kumar, Sudhir [Verfasser], and Bernhard [Akademischer Betreuer] Aigner. "Molecular genetic and phenotypic analysis of ENU-induced mutant mouse models for biomedical research / Sudhir Kumar. Betreuer: Bernhard Aigner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015203213/34.

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31

El, Hakam Carole. "Modèles animaux et pathologies humaines : caractérisation de 3 lignées murines ENU présentant des anomalies du système vestibulaire ou locomoteur." Thesis, Limoges, 2016. http://www.theses.fr/2016LIMO0004/document.

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La mutagenèse chimique aléatoire par l’Ethyl-Nitroso-Urée (ENU), dont la puissance a été largement démontrée au cours de ces dernières décennies dans la création de modèles murins constitue un outil remarquable et essentiel en génomique fonctionnelle. Cette approche est en effet d’un apport considérable pour la compréhension de la fonction des gènes et de leur régulation et constitue un accélérateur pour identifier des éléments clés dans une voie de signalisation. Cette approche systématique, basée sur le criblage simultané d’un grand nombre de souris ne nécessite aucune connaissance préalable

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32

Prückl, Petra Christine [Verfasser]. "Untersuchung zweier ENU-induzierter mutanter Mauslinien mit Fokus auf eine Linie mit einer Punktmutation im Uromodulin-Gen / Petra Christine Prückl." München : Verlag Dr. Hut, 2011. http://d-nb.info/101243222X/34.

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33

Berça, Andressa Scholz. "Avaliação do efeito mitigador de metano entérico em pastagens de capim-marandu consorciadas com amendoim forrageiro ou adubadas com fertilizante nitrogenado /." Jaboticabal, 2018. http://hdl.handle.net/11449/180655.

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Orientador: Ana Cláudia Ruggieri<br>Resumo: O setor agropecuário consiste em um pilar da economia nacional, no entanto está entre os principais responsáveis pelas emissões de gases de efeito estufa (GEE) no mundo, contribuindo com 38% de metano (CH4) proveniente da fermentação entérica. Frente a essa situação, o desafio no sistema produtivo de ruminantes é desenvolver dietas e estratégias de manejo que minimizem a produção de CH4, de modo a reduzir os impactos do aquecimento global e aumentar a eficiência produtiva dos pastos e dos animais. O estudo teve como objetivo avaliar a produção de mas

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34

Tsai, Hsun-Tien. "Characterization and positional cloning of three deaf and vestibular dysfunction mouse mutants generated from the ENU mutagenesis programme - slalom, pardon and junbo." Thesis, Imperial College London, 2002. http://hdl.handle.net/10044/1/8474.

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35

Hartert, Jochen [Verfasser], and Karl [Akademischer Betreuer] Jakobs. "Measurement of the W->enu and Z/gamma* → ee Production Cross-Sections in Proton-Proton Collisions at √s=7 TeV with the ATLAS Experiment = Messung der W->enu und Z/gamma* → ee Produktionswirkungsquerschnitte in Proton-Proton-Kollisionen bei einer Schwerpunktsenergie von √s=7 TeV mit dem ATLAS-Experiment." Freiburg : Universität, 2011. http://d-nb.info/1123465428/34.

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36

Tsipouri, Vasiliki. "Genetic and phenotypic characterisation of ENU mutagenesis-derived mouse mutants : identification of an ABcA1 mutation in a low HDL-, low total cholesterol mouse." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/7748.

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37

Willaredt, Marc August [Verfasser], and Thomas W. [Akademischer Betreuer] Holstein. "Analsysis of the ENU-generated mouse mutant cbs: Primary cilia play a crucial role in cortical development / Marc August Willaredt ; Betreuer: Thomas Holstein." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177040808/34.

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38

Distasio, Andrew. "Novel Regulators of Neural Crest and Neural Progenitor Survival." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593170783550813.

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39

Oliveira, Nicássia de Sousa. "Caracterização fenotípica do camundongo mutante bate palmas induzido pelo agente mutagênico químico ENU (N- Ethyl- N- Nitrosourea) como potencial modelo para a síndrome de Kabuki." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-01122017-162348/.

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O camundongo mutante denominado bate palmas (BALB/cbapa) originou-se de mutagênese química induzida por N-ethyl-N-nitrosourea (ENU). Suas principais características fenotípicas são alterações posturais com movimentos anormais dos membros posteriores quando suspenso pela cauda, simulando o ato de bater palmas. A partir do padrão de herança a mutação foi identificada como autossômica recessiva. Os resultados do sequenciamento do exoma apontaram como forte candidato o gene lysine (K)-specific methyltransferase 2D (kmt2d, também conhecido como mll2 ou mll4), localizado no cromossomo 15 do camundon

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40

Cucchetti, Margot. "Rltpr, a lymphoid-specific protein essential for CD28 costimulation." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4043.

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La reconnaissance d'antigènes par le TCR active des protéines tyrosine kinases qui phosphorylent d'autres substrats intracellulaires dont LAT. Ceci engendre l'activation de molécules telles que PKCθ et CARMA-1. La mutation LatY136F associe des TCR "estropiés" dans le développement de cellules T effectrices générant des désordres lymphoprolifératifs. Nous avons essayé de comprendre les gènes aggravant ou empêchant cette lymphoprolifération en utilisant la mutagénèse ENU. Nous avons identifié une mutation appelée Basilic empêchant le déroulement de la pathologie LatY136F. Basilic est une mutatio

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41

Chan, Ernest Ricky. "Genetic Analysis of Novel Models of Thrombocytopenia and Leucopenia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1248212698.

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42

Yong, Qian Yu. "A screen for modifiers of epigenetic reprogramming." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/50955/1/Qian_Yu_Yong_Thesis.pdf.

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Epigenetic modifiers are the proteins involved in establishing and maintaining the epigenome of an organism. They are particularly important for development. Changes in epigenetic modifiers have been shown be lethal, or cause diseases. Our laboratory has developed an ENU mutagenesis screen to produce mouse mutants displaying altered epigenetic gene silencing. The screen relies on a GFP transgene that is expressed in red blood cells in a variegated manner. In the orginal transgenic FVB mice expression occurs in approximately 55% of red blood cells. During the course of my Masters, I ch

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43

Rangarajan, Vinod K. (Vinod Kashyap) 1975. "End-to-end connectivity across firewalls." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/47623.

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Thesis (S.B. and M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1998.<br>Includes bibliographical references (leaves 53-54).<br>by Vinod K. Rangarajan.<br>S.B.and M.Eng.

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44

Chan, William. "End-to-End Speech Recognition Models." Research Showcase @ CMU, 2016. http://repository.cmu.edu/dissertations/723.

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For the past few decades, the bane of Automatic Speech Recognition (ASR) systems have been phonemes and Hidden Markov Models (HMMs). HMMs assume conditional indepen-dence between observations, and the reliance on explicit phonetic representations requires expensive handcrafted pronunciation dictionaries. Learning is often via detached proxy problems, and there especially exists a disconnect between acoustic model performance and actual speech recognition performance. Connectionist Temporal Classification (CTC) character models were recently proposed attempts to solve some of these issues, name

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45

Le, BeEm V. "Distributed and end-to-end testing." Thesis, Monterey, California : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Dec/09Dec%5FLe.pdf.

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Thesis (M.S. in Systems Engineering Management)--Naval Postgraduate School, December 2009.<br>Thesis Advisor: Huynh, Thomas V. Second Reader: Barrera, Raymond. "December 2009." Description based on title screen as viewed on January 26, 2010. Author(s) subject terms: distributed, End-to-End, combat systems, C4I Systems, pay-per-test, Goal Programming (GP), Distributed Engineering Plant (DEP), E2E Lab, PMW, PEO C4I, NAVSEA, SPAWAR. Includes bibliographical references (p. 53-54). Also available in print.

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46

Donner, Sandra. "ENUM." Universitätsbibliothek Chemnitz, 2004. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200400458.

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ENUM is the mapping of a telephone number from the PSTN to Internet services-telephone number in, URL out. It was developed as a solution to the question of how to find services on the Internet using only a telephone number<br>Workshop "Netz- und Service-Infrastrukturen" ENUM = tElephone NUmber Mapping, definiert die Vorschrift, mit der eine klassische Telefonnummern auf eine Domain eindeutig abgebildet wird (dafür wird DNS genutzt). Das Ziel dabei ist, verschiedene Adressen, Nummern und URLs eines Benutzers unter einer einzigen Rufnummer verfügbar zu machen

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47

Chaudry, Kashif, and Elma Karadza. "End-to-End Application Billing in 3G." Thesis, Linköping University, Department of Science and Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1654.

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<p>We have 3G on the doorstep but nothing seems to attract ordinary people to this technology. To attract the mass market the telecom industry must show something beyond high bit rates. They must show how ordinary people can take advantage of this new technology. This is done by showing the possibilities of the new technology and by demonstrating applications that it will handle. The telecom industry must convince the telecom operators to invest in this technology and the only thing that matters to them is how much revenue they can make by adopting the upcoming technology. </p><p>To convince t

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48

Holmström, Maria. "End-to-end monitoring of mobile services." Thesis, Linköping University, Department of Electrical Engineering, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1671.

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<p>The growing market of mobile services through SMS, MMS, WAP and soon also for 3G protocols, requires efficient test methods to ensure that the customers get what they are paying for and in a reasonable time. Preferably, these tests should be done automatically and come as close to real conditions as possible. It would be valuable to be able to make tests from end to end, i.e. requesting and receiving the mobile services on a real mobile phone and combine that with a system that controls and evaluates the tests. </p><p>This thesis presents a solution to how the part of an end-to-end monitori

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49

Lazar, Mihai. "Empirical modeling of end-to-end jitter." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0019/MQ58472.pdf.

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50

Brown, Ian. "End-to-end security in active networks." Thesis, University College London (University of London), 2001. http://discovery.ucl.ac.uk/3882/.

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Active network solutions have been proposed to many of the problems caused by the increasing heterogeneity of the Internet. These ystems allow nodes within the network to process data passing through in several ways. Allowing code from various sources to run on routers introduces numerous security concerns that have been addressed by research into safe languages, restricted execution environments, and other related areas. But little attention has been paid to an even more critical question: the effect on end-to-end security of active flow manipulation. This thesis first examines the threat mod

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