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Dissertations / Theses on the topic 'Envelop protein'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Samson, Camille. "Une représentation en trois dimensions de l'interface entre l'enveloppe nucléaire et la chromatine." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS048/document.

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Le noyau est un organite caractéristique des cellules eucaryotes et les propriétés mécaniques de ce dernier jouent un rôle essentiel dans le comportement de la cellule, notamment sa motilité, sa polarité et sa survie. Le noyau est entouré par une enveloppe comprenant une membrane interne et une membrane externe, ainsi que de nombreuses protéines. Mes objectifs de thèse étaient de comprendre des mécanismes moléculaires déficients dans deux types de maladies génétiques causées par des mutations dans les lamines: la dystrophie musculaire d’Emery-Dreifuss et les syndromes de type progéroïde.Dans u

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2

Batzenschlager, Morgane. "Diversité fonctionnelle des protéines GIPs/MZT1 (Gamma-tubulin complex protein 3- Interacting Proteins/Mitotic spindle organiZing proTein1) à l'interface nucléo-cytoplasmique chez Arabidopsis thaliana." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ030.

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Chez Arabidopsis, l’enveloppe nucléaire constitue un site de nucléation des microtubules à partir des complexes à gamma-tubuline. Conservées des plantes à l'Homme, les protéines GIPs/MZT1 ont été initialement découvertes comme partenaires d’AtGCP3. J’ai consacré ma thèse à la caractérisation moléculaire et fonctionnelle des AtGIPs et de leurs partenaires à l’interface nucléocytoplasmique. Mes résultats confirment l’appartenance des GIPs aux complexes à gamma-tubuline, et démontrent leur association entre elles et avec TSA1 (TonSoKu [TSK]-Associating protein 1) et l'histone centromérique CenH3.

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3

Bouchnak, Imen. "Biogénèse du chloroplaste : Voies d'import alternatives." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV074.

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Le chloroplaste est un composant majeur de la cellule végétale. Cet organite est le fruit d’une endosymbiose, survenue entre une cellule eucaryote et une cyanobactérie. Ainsi, 95% des gènes codant pour les protéines plastidiales ont été transférés vers le génome nucléaire au cours de l’évolution. En conséquence, la plupart des protéines chloroplastiques sont aujourd’hui codées par le noyau, synthétisées dans le cytosol sous forme de précurseurs dotés d’une une extension N-terminale clivable (le "peptide de transit") et ensuite importées sans les chloroplastes via le système TOC/TIC (Translocon

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4

He, Runtao. "Characterization of dengue virus envelope protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24745.pdf.

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5

Vijayaraghavan, Balaje. "Identification and characterization of protein-protein interactions in the nuclear envelope." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-148432.

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The nuclear envelope forms the interface between the nucleus and the cytoplasm. The nuclear envelope consists of the two concentric lipid membranes, the nuclear pores and the nuclear lamina. The inner nuclear membrane contains hundreds of unique transmembrane proteins showing high tissue diversity. Mutations of some proteins in the nuclear envelope give rise to a broad spectrum of diseases called envelopathies or laminopathies. In this thesis, I aimed to study the functional organization of the nuclear envelope by identifying and characterizing interactions between the nuclear envelope protein

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6

Byland, Rahel. "Trafficking of primate lentiviral envelope proteins." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445339/.

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The assembly of enveloped viruses requires the correct trafficking of the viral envelope or membrane proteins to the site of virus assembly. To understand the molecular and cellular mechanisms in human immunodeficiency virus envelope protein (Env) trafficking, I analysed the activities of putative endocytosis signals in the cytoplasmic domain of Env. Morphological and biochemical analysis of HxB2 Env as well as CD4-Env chimeras revealed two functional endocytosis motifs, the membrane proximal GY712XX0 motif and the C-terminal dileucine motif. Both of these motifs work with equivalent efficienc

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7

Vojta, Aleksandar. "Protein Translocon at the Outer Envelope of Chloroplasts." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-62766.

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8

Xu, Xiaodong. "Expression and characterization of HIV-1 envelope protein." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500515.

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We postulated that gp120 and CD4 interaction might expose cryptic epitopes on gp120 that could be immunogenic and so widen the immunogenic response. A fusion protein of a C clade strain of HIV-1 (HIVCN54) gp120 and full-length human CD4 was constructed and expressed using a recombinant baculovirus system. The protein was purified, characterized and used to immunize rabbits. The antiserum generated had an expected anti-gp120 activity and demonstrated a higher capacity than a control serum raised to gp120 alone to block b12 binding, a marker of neutralization. A formal neutralization assay howev

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9

Reading, Steven A. "Antibodies to the envelope protein of HIV-1." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396875.

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10

Serafin, Ina Loretta. "Epitope mapping of the dengue 3 envelope protein." Thesis, Queensland University of Technology, 1999.

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11

Li, Nannan. "Characterization of two chloroplast envelope membrane proteins." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-157880.

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12

Yu, Ian-Ling, and University of Lethbridge Faculty of Arts and Science. "Functional analysis of two baculovirus envelope proteins." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/680.

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Budded virions of AcMNPV can enter a variety of non-host cells, a characteristic likely due to the presence of GP64, an envelope protein found on a small subset of baculoviruses. Results show that AcMNPV's tropism for vertebrate cells can be restricted - a prerequisite for using AcMNPV for targeted in vivo gene delivery - by replacing the gp64 gene with SeF from SeMNPV. Unlike the relatively well characterized GP64 protein, the significance and function of the F homolog (Ac23, a pathogenicity factor), is poorly understood. How Ac23 might contribute to the faster speed of kill was examined by c

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13

Batrakou, Dzmitry G. "Nuclear envelope transmembrane proteins in differentiation systems." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9981.

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Historically, our perception of the nuclear envelope has evolved from a simple barrier isolating the genome from the rest of a cell to a complex system that regulates functions including transcription, splicing, DNA replication and repair and development. Several recent proteomic studies uncovered a great variety of nuclear envelope transmembrane proteins (NETs). Diseases associated with several nuclear envelope proteins, mostly NETs, affect many tissues e.g. muscle, adipose tissue, skin, bones. Many NETs of the inner nuclear membrane have been shown to interact with chromatin, suggesting that

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14

Kiss, Gabriella. "Matrix protein function in enveloped viruses." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559252.

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Matrix proteins play a central role in the assembly of enveloped pleomorphic viruses. In order to study matrix protein function during assembly, cryo-electron microscopy and tomography studies were carried out on two virus families. Studies of coronavirus virus-like particles and virions revealed that the matrix protein M forms a two-dimensional network of endodornain-Iinked homodimers at the membrane. Structural differences were detected between M on membranes with rigid positive curvature and M on flaccid membranes with variable curvature. Studies of filamentous and round influenza A virus r

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15

Krzyzaniak, Magdalena Anna. "Role of the gM/gN glycoprotein complex in the final assembly and egress of the human cytomegalovirus (HCMV)." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/krzyzaniak.pdf.

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16

Jaffer, Ali Mohammed Hakim. "Multifaceted roles of the transmembrane nuclear envelope protein, Samp1." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-141816.

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The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. In this thesis, I aimed to understand the functional organization of proteins in the nuclear envelope and I focused on investigating the functions of a recently identified INM transmembrane protein, Samp1. We have developed a

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17

Firlej-Kwoka, Ewa. "Protein import into the inner envelope membrane of chloroplasts." Diss., kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8694/.

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18

Ainsworth, Julia. "Comparison of p53 and MAGI-3 regulation mediated by the E6 protein from high-risk human papillomavirus types 18 and 33." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112368.

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The HPV E6-p53 interaction is well-understood, but not for all high-risk HPV types. In addition, HPV E6 p53-independent functions are gaining recognition for their importance in cellular transformation but require clarification. Thus, the aim of this study was two-fold: (1) to gain insight into the p53-E6 interaction for high-risk HPV-33 and, (2) to explore how high-risk HPV E6 proteins targets cellular MAGI-3 for degradation.<br>In vivo and in vitro results indicated that E6 from HPV types 18 and 33 interacted similarly with p53 although, variants of the HPV-33 E6 prototype demonstrated inter

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19

Pawar, Menon Vidya. "Novel plant nuclear envelope-associated coiled-coil proteins." Thesis, Oxford Brookes University, 2015. https://radar.brookes.ac.uk/radar/items/5048d7f0-a708-4f7d-8c5f-9a5bd80321f9/1/.

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The nuclear envelope (NE) is a double lipid bilayer enclosing the eukaryotic genome. The metazoan nucleoskeleton includes the peripheral lamina and the internal nucleoskeleton. The lamina is composed of a network of intermediate filament (IF) proteins called lamins, as well as lamin- and/or chromatin-binding inner nuclear membrane (INM) proteins. The components of the metazoan lamina lack sequence homologues in plants. There is however evidence of a network of nuclear filamentous proteins underlying the NE. This study aims to characterise a novel family of NE-associated proteins (NEAP) in the

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20

Richards, S. "The identification of epidermal cell envelope precursors." Thesis, Bucks New University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382554.

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21

Thomas, Joanne Marie. "Assembly of influenza viruses." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326757.

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22

Zuleger, Nikolaj. "Inner nuclear membrane proteins : targeting and influence on genome organization." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6194.

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The nuclear envelope is a complex double membrane system that separates the activities of the nuclear and cytoplasmic compartments. A recent explosion in the number of proteins associated with this subnuclear organelle together with it now being linked to over 2 dozen diseases indicates the importance of better understanding its functional organisation. This thesis addresses two important questions for this: how do integral proteins of the nuclear envelope get to their sites of function and do any of these proteins direct genome organisation? To address the first question I used FRAP and photo

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23

D'Mello, Felicity Irene Maria. "Structural studies of the hepatitis B virus envelope proteins." Thesis, Royal Veterinary College (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311968.

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24

Forrest, Graham Robert. "Human endogenous retrovirus 3 : evolutionary conservation and function." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312093.

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25

Blagden, Sarah Patricia. "Meteor, a novel Drosophila nuclear envelope-associated protein involved in mitosis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590616.

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26

Chand, Puran. "Molecular and immunological characterisation of a major envelope protein of capripoxvirus." Thesis, University of Surrey, 1992. http://epubs.surrey.ac.uk/2774/.

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Analysis of the proteins of capripoxvirus (KS-1) revealed a 32kd protein that is one of the major structural proteins of the virus and is localised in the virus envelope. Monospecific serum prepared against the 32kd envelope protein neutralised the virus indicating that this protein contains neutralising epitopes. Lymphocyte proliferation studies, using the 32kd protein and peripheral blood mononuclear cells from capripoxvirus (KS-i) vaccinated sheep, showed that this protein strongly induced cellmediated immune responses. The 32kd protein is capripoxvirus specific and induced antibodies in ea

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27

Kuroda, Shun'ichi. "STUDIES ON HEPATITIS B VIRUS ENVELOPE PROTEIN CONTAINING PRE-S PEPTIDE." Kyoto University, 1992. http://hdl.handle.net/2433/168904.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第8019号<br>論農博第1796号<br>新制||農||640(附属図書館)<br>学位論文||H4||N2518(農学部図書室)<br>UT51-92-U255<br>(主査)教授左右田健次, 教授駒野徹, 教授清水昌<br>学位規則第4条第2項該当

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28

Ita, Sergio. "Adaptive Evolution of the SIV Envelope Protein During Early SIV Infection." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493399.

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Primate lentiviruses (PLVs), including human immunodeficiency virus type 1 (HIV-1), HIV type 2 (HIV-2), and the simian immunodeficiency viruses (SIVs), cause persistent lifelong infections despite the presence of virus-specific adaptive immune responses. The target of antibodies is the viral envelope glycoprotein (Env), which is expressed on the surface of virions and infected cells as a trimer of gp120:gp41 heterodimers. SIV env sequence variation arising from evasion of antibodies is well established and closely mimics the pattern observed in HIV-infected human patients, yet despite the exp

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29

Patel, Janisha. "An investigation of the complexes formed between the hepatitis C virus E1 and E2 glycoproteins." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342004.

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30

Pierre, Virginie. "L'acrosome du spermatozoïde de sa biogenèse à son rôle physiologique." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENS035/document.

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Le spermatozoïde est une cellule hautement spécialisée qui doit être capable de réaliser des fonctionsspécifiques pour être capable de féconder un ovocyte. Il doit être capable de réaliser une réactionacrosomique qui consiste en l’exocytose d’une vésicule géante de sécrétion attachée au noyau. Cettevésicule contient des enzymes qui vont permettre au spermatozoïde de traverser la zone pellucide quientoure l’ovocyte. Mon travail a consisté à étudier l’effet d’une des enzymes contenue dansl’acrosome, la sPLA2 de mammifère de groupe X (mGX). C’est la seule phospholipase demammifères parmi les 5 te

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31

Saiz, Ros Natalia. "Herpes virus egress through the nuclear envelope and host response against infections." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28892.

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The nuclear envelope is a highly organised double membrane system that separates the activities of the nuclear and cytoplasmic compartments in eukaryotic systems. The wide range of functions recently associated with the NE and the identification of hundreds of proteins associated with this cellular structure indicates that it is a major signalling node for the cell. Recent work indicates NE functions in signalling innate immune responses to herpesviruses. The viruses, on the other hand, often target or usurp NE functions in different ways. The NE is also a physical barrier that must be overcom

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32

Olsson, Ida. "Functional studies of nuclear envelope-associated proteins in Saccharomyces cerevisiae." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7599.

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Proteins of the nuclear envelope play important roles in a variety of cellular processes e.g. transport of proteins between the nucleus and cytoplasm, co-ordination of nuclear and cytoplasmic events, anchoring of chromatin to the nuclear periphery and regulation of transcription. Defects in proteins of the nuclear envelope and the nuclear pore complexes have been related to a number of human diseases. To understand the cellular functions in which nuclear envelope proteins participate it is crucial to map the functions of these proteins. The present study was done in order to characterize the r

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33

Stephens, D. Michael. "Epitope mapping of antibodies to the envelope proteins of HIV." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239815.

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34

Tajsić, Tamara. "Nuclear envelope proteins modulate Transforming growth factor β superfamily signalling". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610759.

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35

Anna, Newman-Griffis Hare. "Plant nuclear envelope-associated proteins function in development and symbiosis." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542733901078983.

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36

Le, Thanh Phu. "Nuclear envelope transmembrane proteins as mediators of tissue-specific diseases." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28905.

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Many tissue-restricted diseases are linked to mutations in lamins and nuclear envelope transmembrane proteins (NETs). How these mutations in ubiquitously expressed proteins cause such defined diseases is still unknown. It is hypothesized that tissue restricted NETs that are partners of the nuclear lamins/existing linked proteins mediate tissue-specific disease pathologies. Proteomic studies have identified many tissue restricted NETs with effects on the cytoskeleton, gene positioning and regulation. This study investigates potential roles of candidate NETs in mediating tissue restricted diseas

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37

Détourné, Gwénaëlle. "Characterisation of Nuclear Envelope-Associated Proteins (NEAPs) in Arabidopsis thaliana." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAC021/document.

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Au cours de l'évolution, les cellules eucaryotes ont acquis une enveloppe nucléaire (NE) renfermant et protégeant le génome organisé en chromatine, une structure où l'ADN s’enroule autour de protéines histones. La NE est composé de deux membranes : du côté nucléoplasmique, la membrane nucléaire interne (INM) et du côté cytoplasmique, la membrane nucléaire externe. La NE permet la communication entre les deux compartiments par le biais des complexes de pores nucléaires et relie le cytosquelette au nucléosquelette via le complexe LINC (LInker of Nucleoskeleton to Cytoskeleton). Ainsi, le nucléos

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38

Zupanc, Marianne M. "Export and regulatory properties of MalE hybrid proteins in Escherichia coli." Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301885.

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39

Studte, Carsten. "Characterization of the membrane protein Prat1 in the inner envelope of chloroplasts." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149042.

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40

Mudumbi, Krishna Chaitanya. "NUCLEAR ENVELOPE TRANSMEMBRANE PROTEIN DISTRIBUTION AND TRANSPORT STUDIED BY SINGLE-MOLECULE MICROSCOPY." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/489984.

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Biology<br>Ph.D.<br>The nucleus of eukaryotic cells is a vitally important organelle that sequesters the genetic information of the cell, and protects it with the help of two highly evolved structures, the nuclear envelope (NE) and nuclear pore complexes (NPCs). Together, these two structures mediate the bidirectional trafficking of molecules between the nucleus and cytoplasm by forming a barrier. NE transmembrane proteins (NETs) embedded in either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM) play crucial roles in both nuclear structure and functions, including: genome

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Patel, Shalaka S. "Functional analysis of the nuclear envelope associated protein MAF1 and preliminary investigation of the coiled-coil protein TMD1." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1110300984.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2006 March 9.

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Cheng, Heather H. "Envelope and receptor determinants for infection by an immunodeficiency-associated feline leukemia virus /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/5010.

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43

Chellammal, Padmakumar Velayuthan. "Characterisation of Enaptin and Sun1, two novel mammalian nuclear envelope proteins." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972343482.

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44

Duncan, Melanie Laura. "The Final Hurdle: The role of envelope proteins in poxvirus release." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25858.

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Increasing incidence of antimicrobial resistance requires identification of novel drugs, and the human genome presents thousands of potential targets. Intracellular pathogens rely on host proteins and pathways during their entry, replication and egress. Poxviruses are reliant on host Abl tyrosine kinases for release of enveloped virus, the last step in their egress. Release can be inhibited by Abl kinase targeting drug imatinib, with treatment shown to rescue mice infected with a lethal dose of vaccinia virus (VACV). It is speculated that host-targeted antimicrobials are less likely to sele

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45

Al-Haideri, Halah. "Characterization of novel proteins in the cell envelope of Campylobacter jejuni." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/8854/.

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46

Chojnacki, Jakub. "Envelope protein domains of duck hepatitis B virus : role in assembly and infectivity /." Connect to thesis, 2005. http://eprints.unimelb.edu.au/archive/00001738.

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Thesis (Ph.D.)--University of Melbourne, Dept. of Microbiology and Immunology, The Macfarlane Burnet Institute for Medical Research and Public Health, 2006.<br>Typescript. Includes bibliographical references (leaves 155-177).

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47

Sabbatini, G. P., and G. P. Sabbatini. "Rat liver nuclear envelope insulin binding and its effects on endogenous protein kinases." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/23361.

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The postulated model for the insulin - stimulated induction of mRNA efflux (Purrello et al., 1983) is based on the demonstrated binding of insulin to intracellular membrane structures (see chapter 2, section 2.2.1), and the in vitro effect of insulin on nuclear envelope phosphorylation, NTPase activity, and mRNA efflux (see chapter 5, section 5.1). These independent observations have led to the development of a model for the direct induction by insulin, at the level of the nucleus, of mRNA efflux (figure 1.1). However, the specific intracellular insulin binding has been inf erred from kinetic

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48

Kesavardana, Sannula. "Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3493.

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A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease called AIDS (Acquired Immuno Deficiency Syndrome). Despite much effort since the three decades of its discovery, there is no effective vaccine against HIV-1. The envelope glycoprotein of HIV-1 is the most accessible protein on the virion surface and is essential for HIV-1 infection. Thus, this protein is the primary target for HIV-1 vaccine design. However, HIV-1 has acquired

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Kesavardana, Sannula. "Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein." Thesis, 2014. http://etd.iisc.ernet.in/2005/3493.

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A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease called AIDS (Acquired Immuno Deficiency Syndrome). Despite much effort since the three decades of its discovery, there is no effective vaccine against HIV-1. The envelope glycoprotein of HIV-1 is the most accessible protein on the virion surface and is essential for HIV-1 infection. Thus, this protein is the primary target for HIV-1 vaccine design. However, HIV-1 has acquired

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50

Lin, Che-wei, and 林哲緯. "The envelop protein of dengue virus on the maturation of macrophage progenitor cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/83922702263602394032.

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碩士<br>慈濟大學<br>分子生物暨人類遺傳學系碩士班<br>99<br>Dengue fever is an infections threat at tropical region. Infection of dengue virus can result a range of clinical symptoms, including the severe diseases dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) . The clinical symptom of DHF/DSS includes plasma leakage, leukocytopenia, thrombocytopenia and increased vascular permeability. In previous study, we found that the treatment of recombinant dengue envelope protein could promotes the leukocyte differentiation by under the treatment of TPA. In addition, an antagonist for TNF-α pathway seems to

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