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Relevant bibliographies by topics / Environmental and medical sciences / Dissertations / Theses

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Dissertations / Theses on the topic 'Environmental and medical sciences'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Bell, Stephanie K. "Assessment of silicone polymer composites for the trace extraction of herbicides : a tool for environmental forensics." FIU Digital Commons, 2007. http://digitalcommons.fiu.edu/etd/1482.

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Passive samplers are not only a versatile tool to integrate environmental concentrations of pollutants, but also to avoid the use of live sentinel organisms for environmental monitoring. This study introduced the use of magnetic silicone polymer composites (Fe-PDMS) as passive sampling media to pre-concentrate a wide range of analytes from environmental settings. The composite samplers were assessed for their accumulation properties by performing lab experiments with two model herbicides (Atrazine and Irgarol 1051) and evaluated for their uptake properties from environmental settings (waters a

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Meyers, Jacquelyn. "Elucidating Genetic and Environmental Influences on Alcohol-Related Phenotypes." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2830.

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Decades of work has led researchers to believe that risk for complex behavioral phenotypes, such as alcohol use disorders, is likely influenced by multiple genes of small effect acting in conjunction with each other and the environment. Currently, the field of psychiatric genetics is developing methodologies for the identification of genetic risk variants that predispose individuals to the development of complex behavioral disorders. Several challenges related to the complex and polygenic nature of these phenotypes, must be considered. This dissertation study attempts to address these importan

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Mahapatra, Indrani. "Modelling environmental risks and conceptualising 'responsible innovation' for nanotechnology enabled medical applications." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7102/.

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Medical products based on nanomaterials can revolutionise disease diagnosis and management modalities via faster, non-invasive diagnostic techniques and targeted therapeutic delivery and will be used extensively in coming years. The central goal of this thesis was to understand environmental risks that could potentially arise from mass production and wider use of nanotechnology enabled medical products and to gather insights from experts’ perceptions on “Responsible Innovation”. The research presented here uses a mixed methods approach to answer the research questions. By applying probabilisti

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4

Clauson, John. "Cryptococcus neoformans Serotype Groups Found in Clinical and Environmental Isolates." TopSCHOLAR®, 1993. http://digitalcommons.wku.edu/theses/1888.

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Cryptococcus neoformans is an encapsulated yeast responsible for severe meningoencephalitis. The importance of epidemiological studies on cryptococcosis has increased since the beginning of the AIDS epidemic. C. neoformans exists in two varieties containing four serotypes, C. neoformans var. neoformans (serotypes A and D) and C. neoformans var. gattii (serotypes B and C). Locally C. neoformans var. neoformans has been associated with pigeon feces during those months having an average temperature of 64.2°F j(17.8°C) and above. Clinical and environmental isolates of C. neoformans obtained from

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5

Kirkland, Robert. "Actiononaias Ligamentina as a Biomonitor in the Green River: An Unique Approach for Analysis of Environmental Impacts." TopSCHOLAR®, 2002. http://digitalcommons.wku.edu/theses/605.

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Biomonitoring has become an important component in bioassessment programs. It is used to maintain high water quality standards, and determine contaminant levels and biological affects in areas that have been heavily disturbed. The objectives of this research were 1) to improve and apply certain modern biomonitoring techniques and 2) to locate possible contaminant sources affecting the flora and fauna of the Green River and of Mammoth Cave. Actinonaias ligamentina (Lamarck, 1819), a freshwater mussel, was used for interpretation of these impacts as well as refinement of biomonitoring techniques

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Santos, Emmylou C. "Effects of patient and physician gender on the assessment of a medical complaint." Scholarly Commons, 2003. https://scholarlycommons.pacific.edu/uop_etds/2725.

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This study investigated the effects of gender, both patient and physician, on how a medical complaint is perceived and acted upon by health professionals. A 2 x 2 factorial design was used, with gender of physician and patient as the two factors, respectively. The participants were physicians (M.D.s) who were recruited by approaching local hospitals/clinics and requesting their participation in the research. They were asked to respond to a patient vignette and a questionnaire assessing the physician's beliefs about and intentions toward the patient. Using a 2 x 2 ANOVA with a specified .05 sig

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7

Lindh, Joakim. "Development of an Identification System for Modules used in Medical Environments." Thesis, Linköpings universitet, Fysik och elektroteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68065.

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The objective of this thesis work is to find a suitable automatic identification solution for a medical system that utilizes several types of attachments. The solution should be cost efficient and sustainable enough to endure the medical environment. The thesis work was performed for Sectra Mamea AB in Linköping, Sweden. Five suitable solutions where evaluated on a theoretical basis and the feasibility of three of them were also experimentally verified on a more practical level. The experiments where performed on a Xilinx Virtex-5 FPGA platform with solution specific prototype boards, which we

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Runeson, Roma. "Personality, Stress, and Indoor Environmental Symptomatology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5899.

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9

Karssenberg, Derek. "Building dynamic spatial environmental models." Amsterdam : Utrecht : Koninklijk Nederlands Aardrijkskundig Genootschap ; Faculteit Ruimtelijke Wetenschappen, Universiteit Utrecht, 2002. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010371322&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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10

Peterson, Roseann. "On the genetic and environmental associations between body composition, depression symptoms and smoking behavior." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2889.

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Obesity is a serious public health crisis and recent estimates of its incidence are the highest in United States history, with 35% and 17% of American adults and children affected, respectively. The clinical definition of adult obesity is operationalized as a body mass index (BMI) greater than 30 kg/m2. Although the prevalence of common obesity has increased dramatically over the past 30 years–largely thought to be due to changes in the environment, such as high calorie diets and sedentary lifestyles—twin and family studies have shown consistently that relative body weight is under considerabl

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11

Nazir, Muhammad Shahid. "DNA persistence and preservation following environmental insult." Thesis, University of Central Lancashire, 2012. http://clok.uclan.ac.uk/6744/.

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This research was conducted to provide empirical evidence to supplement advice available to the forensic community for the collection of muscle tissue for forensic analysis. This type of collection is normally carried out to determine the identity of individuals following mass disasters, such as plane crashes or natural disasters. DNA degradation was assessed in two model organisms, pig and rabbit (with human DNA as a control), over various time points. Rabbit recombination activating gene (RAG 1) was aligned to identify conserved regions in pig, rabbit and human. Primers were designed and opt

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Ahsan, Rumana. "Association of self-reported different aspects of workplace environment and general wellbeing with maximum workload – A cross- sectional study." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383592.

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Introduction Cardiovascular disease (CVD) is the leading cause of death globally and similarly in United Kingdom (UK), accounting for 31% and 45% annual deaths respectively. Workplace environment consists of different elements (e.g.- physical and psychosocial environment, intra and extra organizational settings) and interrelationship of employer and employee, playing an important role on workers’ health. Current study aims to identify the association of different aspects of workplace environment and general wellbeing with maximum workload (MW) in a working population in UK. Method A cross-sect

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13

Giulio, Disanto. "Genetic and environmental factors influencing susceptibility to the complex disease multiple sclerosis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e44ea559-b48f-4e03-944c-7703f31a3aa6.

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Multiple sclerosis is a complex immune mediated condition of the central nervous system characterized by myelin loss and progressive neurodegeneration. The risk of developing MS is influenced by both genetic and environmental agents and, among them, several lines of evidence support a role for vitamin D deficiency, Epstein-Barr virus (EBV) infection and smoking in the aetiology of this disease. The aim of this work was to further elucidate how nature and nurture act in the causal cascade leading to MS. In chapter 1, I show that the main genetic factor in adult MS (the HLA-DRB1*1501 allele) pla

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Richards, Karen A. "Development of an Instructional Design Model for Problem-Based Online Learning Environments in Continuing Medical Education." NSUWorks, 2004. http://nsuworks.nova.edu/gscis_etd/802.

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Traditional methods that emphasize didactics and rote learning seem deficient to some medical educators. These approaches typically emphasize knowledge acquisition and retention of little relevance to practice. To improve problem solving, knowledge retention, and transfer, the educational strategy and philosophy of problem-based learning (PBL) is being used in medical education on-ground, face-to-face settings. The information age and advances in information technology now provide exciting new online education alternatives for physicians wanting to use this method to meet lifelong learning nee

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Meyers, Ronald B. "A Heuristic for Environmental Values and Ethics, and a Psychometric Instrument to Measure Adult Environmental Ethics and Willingness to Protect the Environment." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039113836.

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Zhang, Rui. "Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/161.

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Several studies suggest that diabetes affects male and female vascular beds differently. However, the mechanisms underlying the interaction of sex and diabetes remain to be investigated. This study investigates whether there are 1) sex differences in the development of abnormal vascular responses and 2) changes in the relative contributions of endothelium-derived relaxing factors (EDRFs) in modulating vascular reactivity of mesenteric arteries taken from streptozotocin (STZ)-induced diabetic rats at early and intermediate stages of the disease (one and eight weeks, respectively). We also inves

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Nichols, Alexander J. "Optical Molecular Sensing in Complex Biological Environments." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226087.

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Although techniques in molecular imaging have advanced considerably over the past several decades, there remain numerous categories of biological molecular targets that are refractory to straightforward imaging. Among these is molecular oxygen, which is vital to a host of physiological as well as pathological processes, as well as the amorphous pigment pheomelanin, which may play a formerly unappreciated role in melanoma carcinogenesis. This thesis describes two related bodies of work that advance techniques in oxygen and pheomelanin imaging, respectively. First, inspired by a desire to unde

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Wamono, Aye Aye. "Exploring students' conceptions of the racial and socio-cultural differences in the learning environment of a medical specialty." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29230.

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Study problem In the education of South African postgraduate medical specialities, various challenges that could have negative impacts on learning are evident. Racial and socio-cultural diversity in South Africa has roots in a previous societal structure that systematically discriminated against particular social groups resulting in significant political, economic and social inequalities between the groupings. With the current processes of transformation underway, the sphere of training postgraduate students in medical specialities reveals visible differences in racial backgrounds between st

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Dong, T. T. Trang. "Chemical composition and toxicity of emissions from burning five vegetation types of Western Australia under experimental combustion conditions." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2019. https://ro.ecu.edu.au/theses/2180.

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This study investigated the emission factors (EFs) for inorganic gases (CO2, CO, SO2, NO and NO2), carbonyls (formaldehyde, acetaldehyde, acetone, propionaldehyde, butyraldehyde and benzaldehyde), volatile organic compounds (VOCs) and particulate matter (PM2.5 and PM10) from laboratory-based fires of vegetation from five typical vegetation types of Western Australia. Species burnt were three grasslands (Spinifex represented by Triodia basedowii, Kimberley grass represented by Sehima nervosum and Heteropogon contortus, and an invasive grass represented by Ehrharta calycina (Veldt grass)), Banks

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Triglia, Concetta. "Interpretive Phenomenological Analysis: Exploring the Experiences of Eye Bank Coordinators When Approaching Families of Decedents for Eye Donation." Diss., NSUWorks, 2018. https://nsuworks.nova.edu/hpd_hs_stuetd/9.

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This dissertation was used to addresses a group of individuals who work as eye bank coordinators. These individuals call families and approach them for eye donations from a loved one who has just passed away. An interpretative phenomenological analysis (IPA) was used to explain the lived experience of eye bank coordinators who call families for consent of eye tissue. The focus was to understand the dedication of the coordinators to giving the gift of sight and exploring the positive and negative experiences of eye bank coordinators. IPA is used for a keen understanding of eye bank coordinators

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Hernandez, Denise Marie. "Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1605.

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Vargas, Leah E. "The Ideology of the Federal Policy and Institutional Review Boards and its Effects on Research." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/208.

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The Federal Policy for the protection of human subjects in research is built on a positivist ideology which effects Institutional Review Boards (IRB) and the research it reviews. An ideological criticism of the regulations through a positivist and postmodernist perspective reveals its initial purpose for biomedical research and its negative effects on research not discussed during its development. Such effects are a shift in focus on regulation over ethics in IRBs, extended oversight of regulations, revisions in research design and objectives, and self-regulation through the punishment of nonc

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Juneby, Hans Bertil. "Sunlight - Essential for Health." Thesis, Umeå universitet, Yrkes- och miljömedicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54040.

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Sunlight is recognized as one of the most important environmental factors that influence human health. There is strong evidence in the scientific literature that adequate exposure to sunlight is associated with many physical and mental health benefits, including reduced overall mortality, prevention of many deadly forms of cancer, as well as a number of metabolic, cardiovascular, autoimmune, infectious and neuropsychatric diseases. Vitamin D deficiency, which is mainly due to insufficient exposure to sunlight, is now one of the most common medical conditions, estimated to affect more than a bi

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Alexander, Andrew William. "MMCTP : a radiotherapy research environment for Monte Carlo and patient-specific treatment planning." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101699.

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Accurate dose calculations and analysis tools are essential to radiotherapy treatment planning. Radiotherapy deliveries utilize the information provided by the treatment planning system and it is generally accepted that clinical outcome can be improved if accuracy in the dose delivery is further improved. Proven Monte Carlo calculations increase the planning accuracy however, most radiotherapy departments do not use Monte Carlo. The McGill Monte Carlo treatment planning system, MMCTP, provides a flexible software environment to integrate Monte Carlo planning with current and new treatment moda

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Krueger, Janice Maria. "Peer learning among family practice residents: Implications for instructional strategies and curriculum enhancement in medical education." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/2454.

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Over the years, graduate medical education has changed in order to create learning environments to best prepare physicians. The present system of residency and hospital affiliation was the model adopted to give students opportunities for active learning along with lecture and observation. This study investigated the varied ways residents learn the knowledge, skills, and dispositions necessary for family practice. A within-site case study approach was used since this was a study of peer learning among family practice residents at a single community based hospital in a university affiliated netw

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Russell-Babin, Kathleen. "Comparison of educational interventions to impact behavioral intent toward pressure ulcer prevention among nurses on medical surgical units." Thesis, NSUWorks, 2013. https://nsuworks.nova.edu/hpd_con_stuetd/5.

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Background: Implementation of evidence-based knowledge in healthcare is challenging with success rates less than optimal at times. This is particularly true in the area of pressure ulcer prevention. Attention to use of the affective domain in educational interventions to implement best practices may be part of the solution. Purpose: The ultimate purpose of this study was to compare the use of two different educational interventions on medical-surgical nurses' behavioral intent to use evidence-based practice in preventing pressure ulcers. Theoretical Framework: The theoretical framework for thi

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Tejomurthula, Sravanthi. "Overexpression of Human Aryl Hydrocarbon Receptor in E.coli Using Two Different Solubility Enhancing Tags." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/261.

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Dioxins such as TCDD are environment pollutants whose toxic effects are mediated via aryl hydrocarbon receptor (AhR) signaling pathway. AhR is a ligand sensitive transcription factor. The unbound AhR resides in cytoplasm as a complex containing p23, Hsp90 and XAP2. Upon ligand binding, AhR undergoes conformational change and translocates into the nucleus. Once the AhR dimerizes with AhR nuclear translocator (Arnt), the chaperone proteins in the complex get dissociated followed by the activation of transcription of various genes such as CYP1A1 and CYP1A2 by AhR-ARNT heterodimer. Various cancers

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Patlolla, Karthik Reddy. "Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/268.

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Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ultimately its bioavailability. Many of the new therapeutically beneficial compounds discovered are lipophilic requiring various solubility enhancement strategies to improve their solubility. Among these strategies, solubility enhancement using solid dispersions is a leading method. To obtain a desirable increase in the solubility of a poorly-soluble compound, a good understanding of the molecular descriptors influencing the enhancement of solubility is essential. Therefore, the major research o

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Yang, Dazhou. "Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/141.

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Guanine-rich telomeric DNA at the end of chromosomes can form a unique DNA tertiary structure - G-quadruplex, which is known to inhibit the binding of telomerase to telomeric regions in cancer cells and thus regulate unrestricted cancer cell growth. Hence, G-quadruplex DNA has recently become a promising target in oncology. The formation of G-quadruplex structures is greatly facilitated by G-quadruplex binding ligands such as Thiazole orange (TO). Compared with other G-quadruplex binding ligands, TO has an intriguing tunable fluorescence property. Upon binding to DNA, the fluorescence of TO ca

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Naidu, Prathyusha. "Catalase-loaded liposomal magnesium phosphate nanoparticles for intracellular protein delivery." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/266.

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Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. Proteins exert higher specificity and more complicated functions; they are well endured and less inclined to evoke immune responses when compared to small molecule drugs. However, exogenous proteins when administered intravenously are prone to immune reactions. Chemical and enzymatic denaturation, and poor penetration into cells are some other challenges for clinical use of intracellular proteins. Proteins that enter cells through endocytosis will be eventually degraded in lysosomes if they d

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Kondepudi, Karthik Chalam. "Computational prediction of enhanced solubility of poorly aqueous soluble drugs prepared by hot melt method." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/267.

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Solubility is the concentration of a solute in a saturated solution at a given temperature and pressure. Solubility of a drug in aqueous media is a pre-requisite to achieve desired concentration of a drug in the systemic circulation. Low aqueous solubility is a major problem encountered with formulation development of recently designed new chemical entities. Solubility of poorly soluble drugs is enhanced by physical and chemical modifications of drug. Shake flask method is the most commonly used experimental method to determine solubility. However, this method has several limitations. A single

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Vutukuru, Naresh Kumar Reddy. "Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/269.

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Nearly 70% of the new chemical entities (NCE’s) discovered are poorly-water soluble drugs and the number of poorly-water soluble drugs are increasing rapidly in the drug discovery. Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor bioavailability. To overcome poor bioavailability, an adsorption technique is developed to enhance the apparent dissolution rate of poorly-water soluble drugs. In this study, two poor-water soluble model drugs, ibuprofen and carvedilol were used. Methanol, DMF, DMSO and PEG400 were used as solvents and

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Vangala, Swathi. "Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/273.

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Purpose. The fate of an orally administered drug is dependent on many parameters before it can reach the systemic circulation, including drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug permeability but they lack or have low expression level of drug metabolism enzyme expression such as CYP3A4, which contributes to significant first-pass gut and liver metabolism for many drugs. Consequently, these cell lines are not sufficient to integrate metabolism when assessing drug absorption. Here, we tes

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Nannapaneni, Vijaysri. "Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying." Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/274.

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Spray drying is widely used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites were subjected to Fourier Transform Infrared Sprectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (XRPD). The data showed that the crystalline model drugs were converted to amorphous form upon spray drying, whereas the physical mixtures did not c

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Higashi, Carol Judie. "A Correlational Study Of The Characteristic Values And Needs With Work Related Factors Among Registered Nurses (Aspiration, Job Satisfaction)." Scholarly Commons, 1986. https://scholarlycommons.pacific.edu/uop_etds/3231.

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Purpose. The purpose of this study was to determine whether there were distinctive interpersonal characteristic values and personality needs which related to registered nurses as a group and, whether these characteristics differed within the categories of various work related factors. Procedures. A multistage cluster sampling procedure was used within a four county area in northern California. A random sample of staff-level nurses from five acute care hospitals provided data for this study. Dependent variables were derived from Gordon's Survey of Interpersonal Values, Edwards Personal Preferen

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Ponnakanti, Himaja. "Soluble and Functional Overexpression of the Ligand Binding Domain of Mouse Aryl Hydrocarbon Receptor in E.Coli." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/260.

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The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor whose toxicity and carcinogenesis is mediated through various polyaromatic hydrocarbons and other environmental pollutants. The role of AhR in carcinogenesis is an area of concern due its altered levels in various tumors. AhR binds structurally diverse ligands and may elicit different responses upon ligand binding. The crystal structure of mouse AhR PAS-A domain was already obtained due to the robustness of mouse AhR in comparison to human. There is a possibility of overexpressing mouse AhR ligand binding

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Kim, Jeong-Lim. "Environmental Factors in Relation to Asthma and Respiratory Symptoms among Schoolchildren in Sweden and Korea." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7418.

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Ivy, Devon. "DEFINING THE RADIORESPONSE OF MOSSY CELLS." CSUSB ScholarWorks, 2018. https://scholarworks.lib.csusb.edu/etd/633.

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Clinical radiotherapy is used to treat a variety of brain tumors within the central nervous system. While effective, it can result in progressive and debilitating cognitive impairment that can diminish quality of life. These impairments have been linked to hippocampal dysfunction and corresponding deficits in spatial learning and memory. Mossy cells are a major population of excitatory neurons located within the dentate hilus and highly involved in hippocampal circuitry. They play critical roles in spatial navigation, neurogenesis, memory, and are particularly vulnerable to a variety of neurot

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Fang, Yunzhou. "A novel intracellular protein delivery system - Magnesium phosphate nanoparticles with cationic lipid coating for catalase intracellular delivery." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/270.

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Protein therapeutics have great potential in treating human disease, especially for those caused by alternations in the functions of intracellular proteins. However, clinical use of protein by intracellular delivery has been hampered by the instability due to proteins' physicochemical properties, and some barriers in the delivery pathway. This study was to prepare and test a novel intracellular protein delivery system - magnesium phosphate nanoparticles with cationic lipid coating for catalase intracellular delivery (LP MgP NP-CAT), and investigate whether it can release the encapsulated catal

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Sachdeva, Sameer. "Design and applications of antibody mimics against epidermal growth factor receptor." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/132.

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Antibodies have been widely used as reagents, homing devices, diagnostics and as therapeutic agents against different targets in clinic and research. Recently a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great potential in various applications and therapeutics, extensive use of full length antibodies has been hampered by the high cost of production, large molecular weight and limited ability to penetrate tumor tissues. These limitations have led to the research for antibody alternatives with lower molecular wei

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Sun, Jingjing. "Exploring the effect of alpha2 receptor on brain 5-HT via a mechanism-based pharmacodynamic model." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/154.

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Purpose: 5-hydroxytryptamine (5-HT) is an important neurotransmitter in depression. It is believed that α 1 and α 2 adrenoceptors mediate the 5-HT level in the brain. The mechanism is complex and not well explored. Especially in different combination treatments, the receptor systems may show varied modulation capability. Additionally, some research has suggested that α 2 heteroceptors may contribute to the time delay problem in dual depression treatment which is thought as the time needed for certain inhibition receptor to get desensitized. We hypothesized that the α 2 adrenoceptors had inhibi

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Mai, Yvonne M. "Use of various health care providers and the associated clinical and humanistic outcomes in an ambulatory Medicare population." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/265.

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Background: The use of complementary and alternative medicine (CAM) and other non-physician health care providers (dentists, optometrists, etc.) has steadily increased in the United States; however, the associated outcomes reported in the Medicare beneficiary population are limited. Objective: To evaluate the utilization of different healthcare providers by Medicare beneficiaries and assess resultant beneficiary outcomes. Methods: Fourteen outreach events targeting Medicare beneficiaries were conducted throughout Northern/Central California during the 2014 open enrollment period. Trained stude

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Barbosa, Melanie Audrey Gomes. "Obesity and environmental pollutants: a reason for concern?" Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/109123.

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Barbosa, Melanie Audrey Gomes. "Obesity and environmental pollutants: a reason for concern?" Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/109123.

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Baptista, Vânia Catarina Vieira. "Impacts of environmental changes on bivalves harvesting in Portuguese coast." Master's thesis, 2012. https://repositorio-aberto.up.pt/handle/10216/107755.

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Baptista, Vânia Catarina Vieira. "Impacts of environmental changes on bivalves harvesting in Portuguese coast." Dissertação, 2012. https://repositorio-aberto.up.pt/handle/10216/107755.

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Magalhães, Mariana Leite Silva de. "Review of Environmental Factors in Antisocial Behavior." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/88436.

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Lima, Daniela da Silva. "Environmental origins of obesity: are phthalates to blame?" Dissertação, 2019. https://hdl.handle.net/10216/120543.

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Silva, Cátia Sofia Rodrigues. "HPLC enantioseparation of tramadol and its metabolites: method validation and application to environmental samples." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/86860.

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Silva, Cátia Sofia Rodrigues. "HPLC enantioseparation of tramadol and its metabolites: method validation and application to environmental samples." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/86860.

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