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Journal articles on the topic 'Enzymatic sensor'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Nagal, Vandana, Sakeena Masrat, Marya Khan, et al. "Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure." Biosensors 13, no. 3 (2023): 375. http://dx.doi.org/10.3390/bios13030375.

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Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synthesis of puffy balls-like cobalt oxide nanostructure using a hydrothermal method and utilize them to modify the working electrode for non-enzymatic electrochemical sensor fabrication. The non-enzymatic electrochemical sensor was utilized for UA determination using cyclic voltammetry (CV) and differen

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2

Fahmy Taha, Mohamed Husien, Hager Ashraf, and Wahyu Caesarendra. "A Brief Description of Cyclic Voltammetry Transducer-Based Non-Enzymatic Glucose Biosensor Using Synthesized Graphene Electrodes." Applied System Innovation 3, no. 3 (2020): 32. http://dx.doi.org/10.3390/asi3030032.

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The essential disadvantages of conventional glucose enzymatic biosensors such as high fabrication cost, poor stability of enzymes, pH value-dependent, and dedicated limitations, have been increasing the attraction of non-enzymatic glucose sensors research. Beneficially, patients with diabetes could use this type of sensor as a fourth-generation of glucose sensors with a very low cost and high performance. We demonstrate the most common acceptable transducer for a non-enzymatic glucose biosensor with a brief description of how it works. The review describes the utilization of graphene and its c

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3

Lansdorp, Bob, William Ramsay, Rashad Hamid, and Evan Strenk. "Wearable Enzymatic Alcohol Biosensor." Sensors 19, no. 10 (2019): 2380. http://dx.doi.org/10.3390/s19102380.

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Transdermal alcohol biosensors have the ability to detect the alcohol that emanates from the bloodstream and diffuses through the skin. However, previous biosensors have suffered from long-term fouling of the sensor element and drift in the resulting sensor readings over time. Here, we report a wearable alcohol sensor platform that solves the problem of sensor fouling by enabling drift-free signals in vivo for up to 24 h and an interchangeable cartridge connection that enables consecutive days of measurement. We demonstrate how alcohol oxidase enzyme and Prussian Blue can be combined to preven

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4

Jamshidnejad-Tosaramandani, Tahereh, Soheila Kashanian, Kobra Omidfar, and Helgi B. Schiöth. "The Role of Nanomaterials in the Wearable Electrochemical Glucose Biosensors for Diabetes Management." Biosensors 15, no. 7 (2025): 451. https://doi.org/10.3390/bios15070451.

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The increasing prevalence of diabetes mellitus necessitates the development of advanced glucose-monitoring systems that are non-invasive, reliable, and capable of real-time analysis. Wearable electrochemical biosensors have emerged as promising tools for continuous glucose monitoring (CGM), particularly through sweat-based platforms. This review highlights recent advancements in enzymatic and non-enzymatic wearable biosensors, with a specific focus on the pivotal role of nanomaterials in enhancing sensor performance. In enzymatic sensors, nanomaterials serve as high-surface-area supports for g

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Leong, Khok Lun, Mui Yen Ho, Xiau Yeen Lee, and Maxine Swee-Li Yee. "A Review on the Development of Non-Enzymatic Glucose Sensor Based on Graphene-Based Nanocomposites." Nano 15, no. 11 (2020): 2030004. http://dx.doi.org/10.1142/s1793292020300042.

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In this 21th century, the demand for glucose sensors in monitoring diabetes reaches a year-on-year peak due to the unhealthy lifestyle of society. Therefore, it is the utmost important task for scientists and researchers to develop a highly efficient and effective glucose sensor. However, conventional enzymatic glucose sensors have showed some drawbacks and the underlying issues faced by enzymatic glucose sensors are outlined in this paper. With the tremendous advancement of science and technology, the field of diabetes monitoring has evolved from enzymatic to nonenzymatic glucose sensor that

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6

Hassan, Mohamed H., Cian Vyas, Bruce Grieve, and Paulo Bartolo. "Recent Advances in Enzymatic and Non-Enzymatic Electrochemical Glucose Sensing." Sensors 21, no. 14 (2021): 4672. http://dx.doi.org/10.3390/s21144672.

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The detection of glucose is crucial in the management of diabetes and other medical conditions but also crucial in a wide range of industries such as food and beverages. The development of glucose sensors in the past century has allowed diabetic patients to effectively manage their disease and has saved lives. First-generation glucose sensors have considerable limitations in sensitivity and selectivity which has spurred the development of more advanced approaches for both the medical and industrial sectors. The wide range of application areas has resulted in a range of materials and fabricatio

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7

Qi, Kaili, Shan Liu, Yuanyuan Li, Rongsheng Chen, and Feng Liang. "One-Dimensional Copper Oxide Nanoparticles Embedded Conductive Nanotube Arrays for High Performance Glucose Sensors." Journal of The Electrochemical Society 168, no. 11 (2021): 116505. http://dx.doi.org/10.1149/1945-7111/ac34cd.

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Non-enzymatic glucose sensors have been extensively exploited recently. But the nanostructured non-enzymatic sensors often suffer from the aggregation of the nanoscale particles and poor conductivity of the composed metal oxides. In this work, a highly conductive one-dimensional carbon nanofilm coated TiO2 nanotube arrays (TiO2@C NTAs) were fabricated as the substrate. Copper oxide nanoparticles (CuOx NPs) were then deposited on the substrate to prepare CuOx NPs/TiO2@C NTAs as the glucose sensor. Under optimal conditions, the CuOx NPs/TiO2@C NTAs sensor shows a linear dependence on glucose con

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8

Kalkozova, Zh K., U. A. Balgimbayeva, A. S. Serikkanov, and Kh A. Abdullin. "SYNTHESIS OF ZINC, COBALT AND COPPER HYDROXY-CARBONATES FOR CREATION OF ELECTROCHEMICAL NON-ENZYMATIC GLUCOSE SENSOR." Herald of the Kazakh-British technical university 21, no. 2 (2024): 273–80. http://dx.doi.org/10.55452/1998-6688-2024-21-2-273-280.

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Non-enzymatic glucose sensors are promising for reusable electrochemical test systems because of their high sensitivity, fast response and ease of operation. A wide class of materials such as noble metal nanoparticles, composites based on carbon nanomaterials, and metal oxides are used to create non-enzymatic glucose sensors. The search for new materials for the creation of highly sensitive glucose sensors is an urgent task. In the present work a new sensor material promising for the creation of glucose biosensors is investigated. Zinc, cobalt and copper hydroxy-carbonates were synthesized by

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9

Li, Longxiao, Yufei Han, Yuzhe Zhang, et al. "Laser-Induced Graphene Decorated with MOF-Derived NiCo-LDH for Highly Sensitive Non-Enzymatic Glucose Sensor." Molecules 29, no. 23 (2024): 5662. https://doi.org/10.3390/molecules29235662.

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Designing and fabricating a highly sensitive non-enzymatic glucose sensor is crucial for the early detection and management of diabetes. Meanwhile, the development of innovative electrode substrates has become a key focus for addressing the growing demand for constructing flexible sensors. Here, a simple one-step laser engraving method is applied for preparing laser-induced graphene (LIG) on polyimide (PI) film, which serves as the sensor substrate. NiCo-layered double hydroxides (NiCo-LDH) are synthesized on LIG as a precursor, utilizing the zeolitic imidazolate framework (ZIF-67), and then r

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10

Domínguez-Aragón, Angelica, Alain Salvador Conejo-Dávila, Erasto Armando Zaragoza-Contreras, and Rocio Berenice Dominguez. "Pretreated Screen-Printed Carbon Electrode and Cu Nanoparticles for Creatinine Detection in Artificial Saliva." Chemosensors 11, no. 2 (2023): 102. http://dx.doi.org/10.3390/chemosensors11020102.

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Creatinine is the final metabolic product of creatine in muscles and a widely accepted biomarker for chronic kidney disease. In this work, we present a non-enzymatic sensor based on an electrochemical pretreated screen-printed carbon electrode (PTSPCE) with electrodeposited Cu nanoparticles (CuNPs). To function in a PoC format, the prepared PTSPCE/CuNPs non-enzymatic sensors were used as disposable elements in a portable potentiostat. The pretreatment using mild anodic and cathodic potentials in PBS resulted in an increased electroactive surface area and improved conductivity, confirmed by cyc

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11

Chen, Tse-Wei, Rasu Ramachandran, Shen-Ming Chen, Ganesan Anushya, and Kumarasamy Ramachandran. "Graphene and Perovskite-Based Nanocomposite for Both Electrochemical and Gas Sensor Applications: An Overview." Sensors 20, no. 23 (2020): 6755. http://dx.doi.org/10.3390/s20236755.

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Perovskite and graphene-based nanocomposites have attracted much attention and been proven as promising candidates for both gas (H2S and NH3) and electrochemical (H2O2, CH3OH and glucose) sensor applications. In this review, the development of portable sensor devices on the sensitivity, selectivity, cost effectiveness, and electrode stability of chemical and electrochemical applications is summarized. The authors are mainly focused on the common analytes in gas sensors such as hydrogen sulfide, ammonia, and electrochemical sensors including non-enzymatic glucose, hydrazine, dopamine, and hydro

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12

Hsu, Cheng-Chih, Wen-Kai Ho, Chyan-Chyi Wu, and Ching-Liang Dai. "The Enzymatic Doped/Undoped Poly-Silicon Nanowire Sensor for Glucose Concentration Measurement." Sensors 23, no. 6 (2023): 3166. http://dx.doi.org/10.3390/s23063166.

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In this work, enzymatic doped/undoped poly-silicon nanowire sensors with different lengths were fabricated using a top-down technique to measure glucose concentration. The sensitivity and resolution of these sensors correlate well with the dopant property and length of nanowire. Experimental results indicate that the resolution is proportional to the nanowire length and dopant concentration. However, the sensitivity is inversely proportional to the nanowire length. The optimum resolution can be better than 0.02 mg/dL for a doped type sensor with length of 3.5 μm. Furthermore, the proposed sens

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13

He, H. "Non-enzymatic optical sensor for penicillins." Talanta 40, no. 3 (1993): 453–57. http://dx.doi.org/10.1016/0039-9140(93)80258-s.

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14

Chakraborty, Titisha, Munmun Das, Chan-Yu Lin, Yen Su, Bing Yuan, and Chyuan-Haur Kao. "ZIF-8 Nanoparticles Based Electrochemical Sensor for Non-Enzymatic Creatinine Detection." Membranes 12, no. 2 (2022): 159. http://dx.doi.org/10.3390/membranes12020159.

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There is a consistent demand for developing highly sensitive, stable, cost-effective, and easy-to-fabricate creatinine sensors as creatinine is a reliable indicator of kidney and muscle-related disorders. Herein, we reported a highly sensitive and selective non-enzymatic electrochemical creatinine sensor via modifying poly(3,4 ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coated indium tin oxide (ITO) substrate by zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs). The topography, crystallinity, and composition of the sensing electrode were characterized by field emission s

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15

He, Jia Hong, Qiang Xu, Zhi Qiang Gao, and Zhong Rong Song. "An Improved Sensitivity Non-Enzymatic Glucose Sensor Based on a Nano-Gold Modified Ag Electrode." Key Engineering Materials 503 (February 2012): 427–31. http://dx.doi.org/10.4028/www.scientific.net/kem.503.427.

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A non-enzymatic glucose sensor based on nano-gold modified Ag electrode was fabricated by two steps. Gold colloid were firstly prepared according to the literature[11] and then a carefully cleaned Ag electrode was dipped into the gold colloid to obtain the non-enzymatic glucose sensor. The structures and morphologies of nano-gold colloid and nano-Au modified electrode were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-Vis absorption spectra. The direct electrocatalytic oxidation of glucose in alkaline medium at this modified electrode has b

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16

Miya, Nonkululeko, Lerato F. Eugeni Machogo-Phao, and Bulelwa Ntsendwana. "Exploring Copper Oxide and Copper Sulfide for Non-Enzymatic Glucose Sensors: Current Progress and Future Directions." Micromachines 14, no. 10 (2023): 1849. http://dx.doi.org/10.3390/mi14101849.

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Millions of people worldwide are affected by diabetes, a chronic disease that continuously grows due to abnormal glucose concentration levels present in the blood. Monitoring blood glucose concentrations is therefore an essential diabetes indicator to aid in the management of the disease. Enzymatic electrochemical glucose sensors presently account for the bulk of glucose sensors on the market. However, their disadvantages are that they are expensive and dependent on environmental conditions, hence affecting their performance and sensitivity. To meet the increasing demand, non-enzymatic glucose

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17

Mahmoud, Amira, Mosaab Echabaane, Karim Omri, et al. "Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing." Molecules 26, no. 4 (2021): 929. http://dx.doi.org/10.3390/molecules26040929.

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Copper-doped zinc oxide nanoparticles (NPs) CuxZn1−xO (x = 0, 0.01, 0.02, 0.03, and 0.04) were synthesized via a sol-gel process and used as an active electrode material to fabricate a non-enzymatic electrochemical sensor for the detection of glucose. Their structure, composition, and chemical properties were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) and Raman spectroscopies, and zeta potential measurements. The electrochemical characterization of the sensors was studied using cyclic voltammetry (CV), electrochemical

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18

Zhu, Jieyi, Meiyan Feng, and Guofu Lian. "Graphene Based FET Biosensor for Organic-Phosphorous Sample Detection and the Enzymatic Analysis." Crystals 12, no. 10 (2022): 1327. http://dx.doi.org/10.3390/cryst12101327.

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Our paper presents a flexible enzymatic acetylcholinesterase graphene based FET biosensor of the target organic phosphorous. The sensor’s purpose is to detect pesticide residues in the field of food safety. In our sensor design, the material is graphene with its functionalization, and graphene based FET structure will be discussed in one section of this paper. The mechanism of this graphene sensor is the enzymatic linked reaction on a sensor surface. The enzyme is fixed on the sensor surface by the linker 3-mercapto propionic acid. Measurement experiments using the biosensor were performed for

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19

Radhakrishnan, Sithara, Seetha Lakshmy, Shilpa Santhosh, Nandakumar Kalarikkal, Brahmananda Chakraborty, and Chandra Sekhar Rout. "Recent Developments and Future Perspective on Electrochemical Glucose Sensors Based on 2D Materials." Biosensors 12, no. 7 (2022): 467. http://dx.doi.org/10.3390/bios12070467.

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Diabetes is a health disorder that necessitates constant blood glucose monitoring. The industry is always interested in creating novel glucose sensor devices because of the great demand for low-cost, quick, and precise means of monitoring blood glucose levels. Electrochemical glucose sensors, among others, have been developed and are now frequently used in clinical research. Nonetheless, despite the substantial obstacles, these electrochemical glucose sensors face numerous challenges. Because of their excellent stability, vast surface area, and low cost, various types of 2D materials have been

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20

Aviha, Reagan, Anju Joshi, and Gymama Slaughter. "Fabrication of Palladium-Decorated Zinc Oxide Nanostructures for Non-Enzymatic Glucose Sensing." Chemosensors 13, no. 6 (2025): 201. https://doi.org/10.3390/chemosensors13060201.

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The growing global burden of diabetes necessitates the development of glucose sensors that are not only reliable and sensitive but also cost-effective and amenable to point-of-care use. In this work, we report a non-enzymatic electrochemical glucose sensor based on laser-induced graphene (LIG), functionalized with zinc oxide (ZnO) and palladium (Pd) nanostructures. The ZnO nanostructures were systematically optimized on the LIG surface by varying electrochemical deposition parameters, including applied potential, temperature, and deposition time, to enhance the electrocatalytic oxidation of gl

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21

Yang, Jialin, Ruizhi Yu, Wanxin Zhang, Yijia Wang, and Zejun Deng. "Electrochemical Determination of Creatinine Based on Multienzyme Cascade-Modified Nafion/Gold Nanoparticles/Screen-Printed Carbon Composite Biosensors." Sensors 25, no. 13 (2025): 4132. https://doi.org/10.3390/s25134132.

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Creatinine serves as a crucial diagnostic biomarker for assessing kidney disease. This work developed portable non-enzymatic and multienzyme-modified electrochemical biosensors for the detection of creatinine based on commercial screen-printed carbon electrodes (SPCEs). The non-enzymatic creatinine sensor was constructed by the electrochemical deposition of AuNPs onto the surface of a pre-activated SPCE by electrochemical activation, followed by the surface modification of a Nafion membrane. The developed AuNPs/SCPE exhibited excellent reproducibility, and the proposed Nafion/AuNPs/SPCE sensor

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22

Vilela, Alice, Eunice Bacelar, Teresa Pinto, et al. "Beverage and Food Fragrance Biotechnology, Novel Applications, Sensory and Sensor Techniques: An Overview." Foods 8, no. 12 (2019): 643. http://dx.doi.org/10.3390/foods8120643.

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Flavours and fragrances are especially important for the beverage and food industries. Biosynthesis or extraction are the two main ways to obtain these important compounds that have many different chemical structures. Consequently, the search for new compounds is challenging for academic and industrial investigation. This overview aims to present the current state of art of beverage fragrance biotechnology, including recent advances in sensory and sensor methodologies and statistical techniques for data analysis. An overview of all the recent findings in beverage and food fragrance biotechnolo

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23

Jiang, Shulan, Yueqi Chen, and Yong Peng. "Ginkgo Leaf Inspired Fabrication of Micro/Nanostructures and Demonstration of Flexible Enzyme-Free Glucose Sensors." Sensors 22, no. 19 (2022): 7507. http://dx.doi.org/10.3390/s22197507.

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Flexible enzyme-free glucose sensors have attracted widespread attention due to their importance and potential applications in clinical diagnosis, flexible wearable devices, and implanted devices in vivo. At present, there are still major problems in fabricating flexible enzyme-free glucose sensors with low detection limits, high stability, and high sensitivity at low cost, hindering their practical application. Here, we report a facile strategy for the fabrication of flexible non-enzymatic glucose sensors using ginkgo leaf as a template. NiO film and PEDOT:PSS composite film were deposited on

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24

Jie Zhang, Jie Zhang, Ri Xia Ri Xia, and Xianchun Li and Jiasheng Xu Xianchun Li and Jiasheng Xu. "Fabrication of Porous Co3O4 Arrays by a Co-Precipitation Method and it Application as a Non-Enzymatic Glucose Sensor." Journal of the chemical society of pakistan 45, no. 4 (2023): 270. http://dx.doi.org/10.52568/001287/jcsp/45.04.2023.

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The porous cobaltosic oxide (Co3O4) arrays has been prepared by a chemical co-precipitation route using the nickel foam as s substrate. Cyclic voltammetry (CV), and ampere current method (i-t curve) are used to explore the non-enzymatic glucose sensor in a three-electrode system. This porous Co3O4 array non-enzymatic sensor shows a sensitivity of 592.8 mA mM1 cm2 in concentration from 0.99 M to 1.073 mM. The porous Co3O4 array sensor electrode also showed low LOD value (0.005 M) and fast response time (4 s). This porous Co3O4 electrode shows a good sensor performance due to these rich redo

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25

Fang, Yueh-Yuan, Yi-Cheng Hsieh, and Cii-Wann Lin. "NANOSTRUCTURED Pt–Ir NON-ENZYMATIC GLUCOSE SENSORS." Biomedical Engineering: Applications, Basis and Communications 25, no. 06 (2013): 1350048. http://dx.doi.org/10.4015/s1016237213500488.

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Over the past decade, the development of non-enzymatic electrochemical biosensors had thriven at a considerable rate. Compared with the traditional enzymatic electrochemical biosensors, the non-enzymatic electrochemical biosensors have the advantages of higher sensitivity and stability. Recently, plenty of researches have devoted to synthesizing new materials, such as bimetallic nanoparticles, and also develop specific nanostructures on the sensor surface to solve the problem of poisoning and increase the selectivity. This work develops two non-enzymatic glucose sensors that are based on nanos

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26

Mohapatra, Jeotikanta, Balakrishna Ananthoju, Vishnu Nair, et al. "Enzymatic and non-enzymatic electrochemical glucose sensor based on carbon nano-onions." Applied Surface Science 442 (June 2018): 332–41. http://dx.doi.org/10.1016/j.apsusc.2018.02.124.

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27

Ramašauskas, Lukas, Rolandas Meškys, and Dalius Ratautas. "Real-time glucose monitoring system containing enzymatic sensor and enzymatic reference electrodes." Biosensors and Bioelectronics 164 (September 2020): 112338. http://dx.doi.org/10.1016/j.bios.2020.112338.

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28

Ye, Jyun-Sian, Chin-Wei Chen, and Chien-Liang Lee. "Pd nanocube as non-enzymatic glucose sensor." Sensors and Actuators B: Chemical 208 (March 2015): 569–74. http://dx.doi.org/10.1016/j.snb.2014.11.091.

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29

Pulidindi, Indra Neel, and Aharon Gedanken. "Carbon nanoparticles based non-enzymatic glucose sensor." International Journal of Environmental Analytical Chemistry 94, no. 1 (2013): 28–35. http://dx.doi.org/10.1080/03067319.2013.782488.

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30

Kang, Xin Huang, Zhi Bin Mai, Xiao Yong Zou, Pei Xiang Cai, and Jin Yuan Mo. "A novel sensitive non-enzymatic glucose sensor." Chinese Chemical Letters 18, no. 2 (2007): 189–91. http://dx.doi.org/10.1016/j.cclet.2006.12.034.

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31

Ali, Md Younus, Dorian Knight, and Matiar M. R. Howlader. "Nonenzymatic Electrochemical Glutamate Sensor Using Copper Oxide Nanomaterials and Multiwall Carbon Nanotubes." Biosensors 13, no. 2 (2023): 237. http://dx.doi.org/10.3390/bios13020237.

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Glutamate is an important neurotransmitter due to its critical role in physiological and pathological processes. While enzymatic electrochemical sensors can selectively detect glutamate, enzymes cause instability of the sensors, thus necessitating the development of enzyme-free glutamate sensors. In this paper, we developed an ultrahigh sensitive nonenzymatic electrochemical glutamate sensor by synthesizing copper oxide (CuO) nanostructures and physically mixing them with multiwall carbon nanotubes (MWCNTs) onto a screen-printed carbon electrode. We comprehensively investigated the sensing mec

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32

Bt Ahamad Mashat, Zamharirah, Faizuan Abdullah, Asnida Abdul Wahab, Muhammad Faiz Md Shakhih, and Anis Suzziani Roslan. "Development of non-enzymatic screen-printed carbon electrode sensor for glucose using cyclic voltammetry." Environmental and Toxicology Management 2, no. 1 (2022): 14–20. http://dx.doi.org/10.33086/etm.v2i1.2542.

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Enzyme-based sensors frequently produce unsatisfactory results such as poor reproducibility and insufficient long-term stability due to the natural instability of enzymes, stringent experimental conditions, and complicated immobilization procedures. Thus, an electrochemical non enzymatic sensor was fabricated by deposition of the multi-walled carbon nanotube (MWCNT) with zinc oxide nanoparticles (ZnO NP) and also molecular imprinted polymer (MIP) on a screen-printed carbon electrode (SPCE). Then, the modified electrode (SPCE/MWCNT/ZnO/MIP) was formed on the surface area of the SPCE. This study

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33

Sakr, Mahmoud A., Karim Elgammal, Anna Delin, and Mohamed Serry. "Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure." Sensors 20, no. 1 (2019): 145. http://dx.doi.org/10.3390/s20010145.

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Non-enzymatic glucose sensing is a crucial field of study because of the current market demand. This study proposes a novel design of glucose sensor with enhanced selectivity and sensitivity by using graphene Schottky diodes, which is composed of graphene (G)/platinum oxide (PtO)/n-silicon (Si) heterostructure. The sensor was tested with different glucose concentrations and interfering solutions to investigate its sensitivity and selectivity. Different structures of the device were studied by adjusting the platinum oxide film thickness to investigate its catalytic activity. It was found that t

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34

Trnková, Libuše, and Iveta Třísková. "Electroanalysis of Insulin on Nanocomposite Electrodes." Chemické listy 117, no. 9 (2023): 551–72. http://dx.doi.org/10.54779/chl20230551.

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The article notes the latest presented work on the electrochemical detection of insulin and presents a critical view of the research and development of its electrochemical non-enzymatic sensors. It monitors the effect of experimental conditions on the insulin oxidation signal and considers the catalytic effects of nanoparticles or nanocomposites deposited on the surfaces of the electrochemical sensor.

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Li, Panpan, Yi Peng, Jinpeng Cai, Yang Bai, Qing Li, and Huan Pang. "Recent Advances in Metal–Organic Frameworks (MOFs) and Their Composites for Non-Enzymatic Electrochemical Glucose Sensors." Bioengineering 10, no. 6 (2023): 733. http://dx.doi.org/10.3390/bioengineering10060733.

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In recent years, with pressing needs such as diabetes management, the detection of glucose in various substrates has attracted unprecedented interest from researchers in academia and industry. As a relatively new glucose sensor, non-enzymatic target detection has the characteristics of high sensitivity, good stability and simple manufacturing process. However, it is urgent to explore novel materials with low cost, high stability and excellent performance to modify electrodes. Metal–organic frameworks (MOFs) and their composites have the advantages of large surface area, high porosity and high

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36

Jemal Kassim Ebrahim. "Review on non-enzymatic electrochemical glucose sensor of hybrid nanostructure materials." Magna Scientia Advanced Research and Reviews 1, no. 2 (2021): 01–017. http://dx.doi.org/10.30574/msarr.2021.1.2.0028.

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This review made on the progress of five years non-enzymatic electrochemical sensing of glucose. Following a brief discussion of the merits and limitations of enzymatic glucose sensors, we discuss the history of unraveling the mechanism of direct oxidation of glucose and theories of non-enzymatic electro-catalysis. And also we discussed non-enzymatic glucose electrodes based on the use of the metals (platinum, gold, nickel, copper, of alloys and bimetals, of carbon material), and of metal-metal oxides and some electrochemical techniques which are used to analyze different real samples accordin

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37

Yu, Xiaojiao, Jie Zhang, Xiyan Tang, et al. "Preparation and performance of non-enzymatic glucose sensor electrode based on nanometer cuprous oxide." Nanomaterials and Nanotechnology 8 (January 1, 2018): 184798041879352. http://dx.doi.org/10.1177/1847980418793526.

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Cuprous oxide nanometer thin-film electrodes of different structures were successfully prepared by electrochemical deposition. The structures and properties of the samples were characterized by X-ray diffractometer, ultraviolet–visible and scanning electron microscope. The cuprous oxide thin-film electrode was used as a non-enzymatic glucose sensor, and the electrocatalytic response of the sensor for glucose was investigated by cyclic voltammetry. Results showed that cuprous oxide with higher purity, neat morphology structure and uniform grain size was prepared. The cuprous oxide nanometer thi

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Lee, Ahyun, Wooseok Kang, and Jin-sil Choi. "Highly Enhanced Enzymatic Activity of Mn-Induced Carbon Dots and Their Application as Colorimetric Sensor Probes." Nanomaterials 11, no. 11 (2021): 3046. http://dx.doi.org/10.3390/nano11113046.

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Nanomaterial-based enzyme mimetics (nanozymes) have attracted significant interest because of their lower cost and higher stability compared to natural enzymes. In this study, we focused on improving the enzymatic properties of metal induced N-doped carbon dots (N-CDs), which are nanozymes of interest, and their applications for sensory systems. For this purpose, Mn(acetate)2 was introduced during the synthetic step of N-doped carbon dots, and its influence on the enzymatic properties of Mn-induced N-CDs (Mn:N-CDs) was investigated. Their chemical structure was analyzed through infrared spectr

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Al-Graiti, Wed. "“A review of classifications of enzymatic and non-enzymatic electrodes-based nano-carbon for detection of glucose”." Journal of Education for Pure Science- University of Thi-Qar 11, no. 2 (2022): 90–107. http://dx.doi.org/10.32792/jeps.v11i2.118.

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In recent years, the number of people having diabetes mellitus is steadily increasing in countries known by low and middle income. Millions of them have been diagnosed with high blood sugar. Diabetes mellitus is related to irregular carbohydrates metabolism with difficulty managing blood glucose which by the time leads to serious damage to nervous system or even macrovascular, or blood vessels. Therefore, the demand for advanced devices for glucose monitoring is highly growing. A bio-sensor is a signal detecting device generated from reactions either biological or chemical. They can be used fo

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Caldevilla, Renato, Stephanie L. Morais, Agostinho Cruz, et al. "Electrochemical Chemically Based Sensors and Emerging Enzymatic Biosensors for Antidepressant Drug Detection: A Review." International Journal of Molecular Sciences 24, no. 10 (2023): 8480. http://dx.doi.org/10.3390/ijms24108480.

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Major depressive disorder is a widespread condition with antidepressants as the main pharmacological treatment. However, some patients experience concerning adverse reactions or have an inadequate response to treatment. Analytical chromatographic techniques, among other techniques, are valuable tools for investigating medication complications, including those associated with antidepressants. Nevertheless, there is a growing need to address the limitations associated with these techniques. In recent years, electrochemical (bio)sensors have garnered significant attention due to their lower cost,

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Hajimiri, Hasti, Seyed Hamid Safiabadi Tali, Muna Al-Kassawneh, Zubi Sadiq, and Sana Jahanshahi-Anbuhi. "Tablet-Based Sensor: A Stable and User-Friendly Tool for Point-of-Care Detection of Glucose in Urine." Biosensors 13, no. 9 (2023): 893. http://dx.doi.org/10.3390/bios13090893.

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The colorimetric detection of glucose in urine through enzymatic reactions offers a low-cost and non-invasive method to aid in diabetes management. Nonetheless, the vulnerability of enzymes to environmental conditions, particularly elevated temperatures, and their activity loss pose significant challenges for transportation and storage. In this work, we developed a stable and portable tablet sensor as a user-friendly platform for glucose monitoring. This innovative device encapsulates glucose oxidase and horseradish peroxidase enzymes with dextran, transforming them into solid tablets and ensu

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Stanciu, Lia, Melania-Liliana Arsene, and Constanta Parlog. "IMMOBILIZATION OF ALCOHOL OXIDASE IN SiO2 MATRIX PREPARED BY SOL-GEL METHOD." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 6, no. 6 (1998): 77–86. http://dx.doi.org/10.48141/sbjchem.v6.n6.1998.86_1998.pdf.

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The possibility of obtaining a biochemical sensor for colorimetric determination was studied for this purpose, we have used the redox indicator 2.6-dichlorophenolindophenol (DCIP) and the binary enzymatic system composed by alcohol oxidase (AO) and peroxidase (PER). The binary enzymatic system immobilized in an inert SiO2 matrix was obtained by modfied sol-gel process. The chromogen and binary enzymatic system immobilization into a SiO2 matrix was confirmed by I.R. spectroscopy. By immobilization of the enzymatic system, both the stability and enzymatic activity increase.

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Chu, Thi Xuan. "Non-enzymatic Glucose Sensor Based on CuO Nanoplates." Journal of Science and Technology - Technical Universities 30.7, no. 146 (2020): 54–57. http://dx.doi.org/10.51316/30.7.10.

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We have successfully fabricated an electrochemical sensor for non-enzymatic glucose measurement based on copper oxide (CuO) nanoplates. CuO nanoplates were synthesized by a facile hydrothermal method at 180 oC for 23 h without using any surfactants. Filed-emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD) were used to characterize morphologies and crystal structures of synthesized CuO nanoplates. A mixture of CuO nanoplates and polytetrafluoroethylene with mass ratio 0.15:1 was compressed at 9800 kPa onto platinum (Pt) to form Pt/CuO disk and it has been used as a worki

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Huda, N., P. L. Sambegoro, N. L. W. Septiani, M. Iqbal, A. Sholehah, and B. Yuliarto. "Modification of screen-printed carbon electrode (SPCE) by the Nafion functionalized silicon nanoparticles (SiNP/Naf) materials in non-enzymatic electrochemical sensor for uric acid (UA) detection." Journal of Physics: Conference Series 2243, no. 1 (2022): 012106. http://dx.doi.org/10.1088/1742-6596/2243/1/012106.

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Abstract A non-enzymatic electrochemical sensor has been successfully developed to detect uric acid (UA) based on a modified screen-printed carbon electrode (SPCE) using Nafion functionalized silicon nanoparticles. Silicon nanoparticles (SiNPs) material is used because of their advantages, including its abundant availability, good biocompatibility, and adjustable porosity and surface area according to the synthesis method used. Nafion is a sulfonated tetrafluoroethylene-based fluoropolymer-copolymer that has been widely used for electrochemical sensors and is functioned as a stabilizer of the

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Md Shakhih, Muhammad Faiz, Anis Suzziani Rosslan, Anas Mohd Noor, Santheraleka Ramanathan, Azwan Mat Lazim, and Asnida Abdul Wahab. "Review-Enzymatic and Non-Enzymatic Electrochemical Sensor for Lactate Detection in Human Biofluids." Journal of The Electrochemical Society 168, no. 6 (2021): 067502. http://dx.doi.org/10.1149/1945-7111/ac0360.

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Melo, Wiviane E. R. de, Karoline S. Nantes, Ana L. H. K. Ferreira та ін. "A Disposable Carbon-Based Electrochemical Cell Modified with Carbon Black and Ag/δ-FeOOH for Non-Enzymatic H2O2 Electrochemical Sensing". Electrochem 4, № 4 (2023): 523–36. http://dx.doi.org/10.3390/electrochem4040033.

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Hydrogen peroxide (H2O2) is an essential analyte for detecting neurodegenerative diseases and inflammatory processes and plays a crucial role in pharmaceuticals, the food industry, and environmental monitoring. However, conventional H2O2 detection methods have drawbacks such as lengthy analysis times, high costs, and bulky equipment. Non-enzymatic sensors have emerged as promising alternatives to overcome these limitations. In this research, we introduce a simple, portable, and cost-effective non-enzymatic sensor that uses carbon black (CB) and silver nanoparticle-modified δ-FeOOH (Ag/δ-FeOOH)

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Feeney, Stanley G., Joelle M. J. LaFreniere, and Jeffrey Mark Halpern. "Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments." Polymers 13, no. 21 (2021): 3706. http://dx.doi.org/10.3390/polym13213706.

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The use of nanofibers creates the ability for non-enzymatic sensing in various applications and greatly improves the sensitivity, speed, and accuracy of electrochemical sensors for a wide variety of analytes. The high surface area to volume ratio of the fibers as well as their high porosity, even when compared to other common nanostructures, allows for enhanced electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. Nanofibers have the potential to rival and replace materials used in electrochemical sensing. As more types of nanofibers are developed and tested for new applic

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Gričar, Ema, Josip Radić, Boštjan Genorio, and Mitja Kolar. "Highly Sensitive and Selective Graphene Nanoribbon Based Enzymatic Glucose Screen-Printed Electrochemical Sensor." Sensors 22, no. 24 (2022): 9590. http://dx.doi.org/10.3390/s22249590.

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A simple, sensitive, cost effective, and reliable enzymatic glucose biosensor was developed and tested. Nitrogen-doped heat-treated graphene oxide nanoribbons (N-htGONR) were used for modification of commercially available screen-printed carbon electrodes (SPCEs), together with MnO2 and glucose oxidase. The resulting sensors were optimized and used to detect glucose in a wide linear range (0.05–5.0 mM) by a simple amperometric method, where the limit of detection was determined to be 0.008 mM. (lifetime), and reproducibility studies were also carried out and yielded favorable results. The sens

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Mao, Qi, Weixuan Jing, Weizhuo Gao, et al. "High-Sensitivity Enzymatic Glucose Sensor Based on ZnO Urchin-like Nanostructure Modified with Fe3O4 Magnetic Particles." Micromachines 12, no. 8 (2021): 977. http://dx.doi.org/10.3390/mi12080977.

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A novel and efficient enzymatic glucose sensor was fabricated based on Fe3O4 magnetic nanoparticles (Fe3O4MNPs)-modified urchin-like ZnO nanoflowers (ZnONFs). ZnONFs were hydrothermally synthesizing on a flexible PET substrate. Fe3O4MNPs were deposited on the surface of the ZnONFs by the drop-coating process. The results showed that the urchin-like ZnONFs provided strong support for enzyme adsorption. For Fe3O4MNPs, it significantly promoted the redox electron transfer from the active center of GOx to the ZnO nanoflowers beneath. More importantly, it promoted the hydrolysis of H2O2, the interm

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Aparicio-Martínez, Eider Pedro, Alejandro Vega-Rios, Velia Osuna, and Rocio Berenice Dominguez. "Salivary Glucose Detection with Laser Induced Graphene/AgNPs Non-Enzymatic Sensor." Biosensors 13, no. 2 (2023): 207. http://dx.doi.org/10.3390/bios13020207.

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The tailoring of novel nanomaterials for sensitive glucose detection through a non-enzymatic mechanism is currently under intensive research. Here, we present a laser-induced graphene (LIG) electrode decorated with silver nanoparticles (AgNPs) as a catalytic element for the direct electrooxidation of glucose. The AgNPs were synthesized through cyclic voltammetry using LIG as a template, resulting in a porous tridimensional assembly with anchored nanostructures. The characterization corroborated the formation of LIG/AgNPs composite with distinctive peaks attributed to Ag2O and AgO interaction w

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