Relevant bibliographies by topics / Enzyme-degradable

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  2. Dissertations / Theses
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  4. Conference papers

Academic literature on the topic 'Enzyme-degradable'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Enzyme-degradable"

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Chen, Ginger, Shadi Taghavi, Dale Marecak, and Brian G. Amsden. "Tough and Enzyme-Degradable Hydrogels." Macromolecular Materials and Engineering 303, no. 1 (July 24, 2017): 1700162. http://dx.doi.org/10.1002/mame.201700162.

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Rypáček, František, and Václav Škarda. "Self-Degradable Hydrogel with Covalently Bound Proteolytic Enzyme." Collection of Czechoslovak Chemical Communications 60, no. 11 (1995): 1986–94. http://dx.doi.org/10.1135/cccc19951986.

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Biodegradable hydrogel as a self-degradable system for controlled release of biologically active macromolecules was prepared from the biodegradable poly[N5-(2-hydroxyethyl)-L-glutamine-stat -N5-(2-methacryloyloxyethyl)-L-glutamine -stat-L-glutamic acid], to which a proteolytic enzyme, papain, was covalently bound. The polymer-enzyme conjugate was crosslinked by radical copolymerization with acrylamide. Significantly improved thermal stability and increased pH optimum of the catalytic activity of conjugated papain was observed. Self-degradation of the hydrogel by the action of encapsulated papain could be triggered by the addition of a low-molecular-weight enzyme activator, such as dithioerythritol.
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Murase, S. K., L. P. Lv, A. Kaltbeitzel, K. Landfester, L. J. del Valle, R. Katsarava, J. Puiggali, and D. Crespy. "Amino acid-based poly(ester amide) nanofibers for tailored enzymatic degradation prepared by miniemulsion-electrospinning." RSC Advances 5, no. 68 (2015): 55006–14. http://dx.doi.org/10.1039/c5ra06267e.

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Lévesque, Stéphane G., and Molly S. Shoichet. "Synthesis of Enzyme-Degradable, Peptide-Cross-Linked Dextran Hydrogels." Bioconjugate Chemistry 18, no. 3 (May 2007): 874–85. http://dx.doi.org/10.1021/bc0602127.

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Bacinello, Daniel, Elisabeth Garanger, Daniel Taton, Kam Chiu Tam, and Sébastien Lecommandoux. "Enzyme-Degradable Self-Assembled Nanostructures from Polymer–Peptide Hybrids." Biomacromolecules 15, no. 5 (April 10, 2014): 1882–88. http://dx.doi.org/10.1021/bm500296n.

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Whang, Minji, Hyeonji Yu, and Jungwook Kim. "Superabsorbent Polymer Network Degradable by a Human Urinary Enzyme." Polymers 13, no. 6 (March 17, 2021): 929. http://dx.doi.org/10.3390/polym13060929.

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Owing to its superior water absorption capacity, superabsorbent polymer (SAP) based on a poly (acrylic acid) network is extensively used in industrial products such as diapers, wound dressing, or surgical pads. However, because SAP does not degrade naturally, a massive amount of non-degradable waste is discarded daily, posing serious environmental problems. Considering that diapers are the most widely used end-product of SAP, we created one that is degradable by a human urinary enzyme. We chose three enzyme candidates, all of which have substrates that were modified with polymerizable groups to be examined for cleavable crosslinkers of SAP. We found that the urokinase-type plasminogen activator (uPA) substrate, end-modified with acrylamide groups at sufficient distances from the enzymatic cleavage site, can be successfully used as a cleavable crosslinker of SAP. The resulting SAP slowly degraded over several days in the aqueous solution containing uPA at a physiological concentration found in human urine and became shapeless in ~30 days.
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Donskyi, Ievgen S., Ying Chen, Philip Nickl, Guy Guday, Haishi Qiao, Katharina Achazi, Andreas Lippitz, et al. "Self-degrading graphene sheets for tumor therapy." Nanoscale 12, no. 26 (2020): 14222–29. http://dx.doi.org/10.1039/d0nr02159h.

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Tsao, Nadia H., and Elizabeth A. H. Hall. "Enzyme-Degradable Hybrid Polymer/Silica Microbubbles as Ultrasound Contrast Agents." Langmuir 32, no. 25 (June 16, 2016): 6534–43. http://dx.doi.org/10.1021/acs.langmuir.6b01075.

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Wu, Haiyan, Huifeng Wang, Fang Cheng, Fujian Xu, and Gang Cheng. "Synthesis and characterization of an enzyme-degradable zwitterionic dextran hydrogel." RSC Advances 6, no. 37 (2016): 30862–66. http://dx.doi.org/10.1039/c6ra00550k.

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A matrix metalloproteinase peptide cross-linked dextran hydrogel was synthesized. Dextran was modified with carboxybetaine to resist nonspecific protein adsorption and cell attachment. The degradable hydrogel is a good candidate for soft tissue engineering applications.
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Shalaby, Waleed S. W., Garnet E. Peck, and Kinam Park. "Release of dextromethorphan hydrobromide from freeze-dried enzyme-degradable hydrogels." Journal of Controlled Release 16, no. 3 (August 1991): 355–63. http://dx.doi.org/10.1016/0168-3659(91)90013-4.

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Dissertations / Theses on the topic "Enzyme-degradable"

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Liu, Wen. "BREAKDOWN OF HARD-DEGRADABLE POLYSACCHARIDES IN WETLANDS." Kyoto University, 2016. http://hdl.handle.net/2433/215584.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第19758号
農博第2154号
新制||農||1039(附属図書館)
学位論文||H28||N4974(農学部図書室)
32794
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 佐藤 健司, 教授 山下 洋, 准教授 豊原 治彦
学位規則第4条第1項該当
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Insua, I., M. Petit, L. D. Blackman, R. Keogh, Anaïs Pitto-Barry, R. K. O'Reilly, F. A. Peacock, A. M. Krachler, and F. Fernandez-Trillo. "Structural Determinants of the Stability of Enzyme‐Responsive Polyion Complex Nanoparticles Targeting Pseudomonas aeruginosa’s Elastase." 2018. http://hdl.handle.net/10454/15921.

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Yes
Here, we report how the stability of polyion complex (PIC) particles containing Pseudomonas aeruginosa’s elastase (LasB) degradable peptides and antimicrobial poly(ethylene imine) is significantly improved by careful design of the peptide component. Three LasB‐degradable peptides are reported herein, all of them carrying the LasB‐degradable sequence −GLA− and for which the number of anionic amino acids and cysteine units per peptide were systematically varied. Our results suggest that while net charge and potential to cross‐link via disulfide bond formation do not have a predictable effect on the ability of LasB to degrade these peptides, a significant effect of these two parameters on particle preparation and stability is observed. A range of techniques has been used to characterize these new materials and demonstrates that increasing the charge and cross‐linking potential of the peptides results in PIC particles with better stability in physiological conditions and upon storage. These results highlight the importance of molecular design for the preparation of PIC particles and should underpin the future development of these materials for responsive drug delivery.
Wellcome Trust, EPSRC, Birminghan Science City, European Regional Development Fund, University of Birmingham
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"Thermo-responsive Copolymers with Enzyme-dependent Lower Critical Solution Temperatures for Endovascular Embolization." Master's thesis, 2019. http://hdl.handle.net/2286/R.I.53812.

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abstract: Minimally invasive endovascular embolization procedures decrease surgery time, speed up recovery, and provide the possibility for more comprehensive treatment of aneurysms, arteriovenous malformations (AVMs), and hypervascular tumors. Liquid embolic agents (LEAs) are preferred over mechanical embolic agents, such as coils, because they achieve homogeneous filling of aneurysms and more complex angioarchitectures. The gold standard of commercially available LEAs is dissolved in dimethyl sulfoxide (DMSO), which has been associated with vasospasm and angiotoxicity. The aim of this study was to investigate amino acid substitution in an enzyme-degradable side group of an N-isopropylacrylamide (NIPAAm) copolymer for the development of a LEA that would be delivered in water and degrade at the rate that tissue is regenerated. NIPAAm copolymers have a lower critical solution temperature (LCST) due to their amphiphilic nature. This property enables them to be delivered as liquids through a microcatheter below their LCST and to solidify in situ above the LCST, which would result in the successful selective occlusion of blood vessels. Therefore, in this work, a series of poly(NIPAAm-co-peptide) copolymers with hydrophobic side groups containing the Ala-Pro-Gly-Leu collagenase substrate peptide sequence were synthesized as in situ forming, injectable copolymers.. The Gly-Leu peptide bond in these polypeptides is cleaved by collagenase, converting the side group into the more hydrophilic Gly-Ala-Pro-Gly-COOH (GAPG-COOH), thus increasing the LCST of the hydrogel after enzyme degradation. Enzyme degradation property and moderate mechanical stability convinces the use of these copolymers as liquid embolic agents.
Dissertation/Thesis
Masters Thesis Biomedical Engineering 2019
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Wanakule, Prinda 1985. "Development and evaluation of enzymatically-degradable hydrogel microparticles for pulmonary delivery of nanoparticles and biologics." Thesis, 2012. http://hdl.handle.net/2152/23398.

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The emerging class of biologic drugs, including proteins, peptides, and gene therapies, are widely administered by injection, despite potential systemic side effects. Rational design of targeted carriers that can be delivered non-invasively, with reduced side effects, is essential for the success of these therapies, as well as for the improvement of patient compliance and quality of life. One potential approach is to take advantage of specific physiological cues, such as enzymes, which would trigger drug release from a drug carrier. Enzymatic cleavage is highly specific and could be tailored for certain diseased tissues where specific enzymes are up regulated. Enzymatically-degradable hydrogels, which incorporate an enzyme- cleavable peptide into the network structure, have been extensively reported for releasing drugs for tissue engineering applications. These studies showed that a rapid response and corresponding drug release occurs upon enzyme exposure, whereas minimal degradation occurs without enzyme. Recently, Michael addition reactions have been developed for the synthesis of such enzymatically-degradable hydrogels. Michael addition reactions occur under mild physiological conditions, making them ideally suited for polymerizing hydrogels with encapsulated biologic drugs without affecting its bioactivity, as in traditional polymerization and particle synthesis. The focus of my research was to create enzymatically-degradable hydrogel microparticles, using Michael addition chemistry, to evaluate for use as an inhalable, disease-responsive delivery system for biologic drugs and nanoparticles. In this dissertation, I utilize bioconjugation and Michael addition chemistries in the design and development of enzymatically-degradable hydrogels, which may be tailored to a multitude of disease applications. I then introduce a new method of hydrogel microparticle, or microgel, synthesis known as the Michael Addition During Emulsion (MADE) method. These microgel carriers were evaluated in vitro, and found to exhibit triggered release of encapsulated biologic drugs in response to enzyme, no significant cytotoxic effects, and the ability the avoid rapid clearance by macrophages. Lastly, in vivo studies in mice were conducted, and microgels were found to exhibit successful delivery to the deep lung, as well as prolonged pulmonary retention after intratracheal aerosol delivery. In conclusion, a new class of enzymatically-degradable microgels were successfully developed and characterized as a versatile and promising new system for pulmonary, disease-responsive delivery of biologic drugs.
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Book chapters on the topic "Enzyme-degradable"

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Shalaby, Waleed S. W., William E. Blevins, and Kinam Park. "Enzyme-Degradable Hydrogels." In ACS Symposium Series, 484–92. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0467.ch031.

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Dobashi, Toshiaki, Michiru Koike, Kentaro Kobayashi, Yasuyuki Maki, Takao Yamamoto, and Susumu Tanaka. "An Application of Microcapsules Having Enzyme-degradable Gel Membrane to Cell Culture." In Gels: Structures, Properties, and Functions, 149–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00865-8_21.

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Shalaby, Waleed S. W., and Kinam Park. "Hydrogels: Enzyme-Degradable." In Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 3906–17. Taylor & Francis, 2016. http://dx.doi.org/10.1081/e-ebpp-120051896.

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Allenza, Paul, Julie Schollmeyer, and Ronald P. Rohrbach. "Evaluating Biodegradable Plastics with in vitro Enzyme Assays: Additives Which Accelerate the Rate of Biodegradation." In Degradable Materials, 357–80. CRC Press, 2018. http://dx.doi.org/10.1201/9781351071321-14.

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Conference papers on the topic "Enzyme-degradable"

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Ferdes, Mariana, and Rodica Roxana Constantinescu. "Biological pretreatment of waste from the leather industry to obtain biogas through anaerobic co-digestion processes - A review." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.8.

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The leather industry produces a relatively high amount of hard degradable waste, with a negative impact on the environment. This waste usually contains two major categories of residues, namely animal fat and residues containing mostly proteins, suitable for biogas conversion. Obtaining biogas from leather waste by co-digestion with vegetable waste can be a sustainable and eco-friendly alternative to conventional energy from fuels. Anaerobic co-digestion is now considered to reduce waste from various sources and turn it into energy, generating in addition a digestate used as fertilizer in agriculture. This waste is relatively resistant to transformation into an easily fermentable substrate for anaerobic digestion to produce biogas. Thus, the methane yield can be significantly improved by biological treatments with enzymes and enzyme complexes, with microorganisms selected and used as inoculum or by mixed methods, which include other physical or chemical treatments. This paper aims to show the main methods of biological treatment of leather industry waste, in order to increase the yield of biogas by co-digestion with plant materials.
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