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Dissertations / Theses on the topic 'Enzyme function'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Friemann, Rosmarie. "Structure-function studies of iron-sulfur enzyme systems /." Uppsala : Dept. of Molecular Biology, Swedish Univ. of Agricultural Sciences, 2005. http://epsilon.slu.se/a504.pdf.

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2

O'Neil, Crystal L. "Enzyme Exploitation: Manipulating Enzyme Function for Therapy, Synthesis and Natural Product Modification." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1293722936.

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3

Gwozd, Chantelle Sabrina. "The structural basis of ubiquitin conjugating enzyme function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22989.pdf.

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4

Friemann, Rosmarie. "Structure-function studies of iron-sulfur enzyme systems /." Uppsala : Dept. of Molecular Biology, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a504-ab.html.

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5

Roden, D. L. "High specificity automatic function assignment for enzyme sequences." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1321566/.

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The number of protein sequences being deposited in databases is currently growing rapidly as a result of large-scale high throughput genome sequencing efforts. A large proportion of these sequences have no experimentally determined structure. Also, relatively few have high quality, specific, experimentally determined functions. Due to the time, cost and technical complexity of experimental procedures for the determination of protein function this situation is unlikely to change in the near future. Therefore, one of the major challenges for bioinformatics is the ability to automatically assign

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6

Szeto, Michelle Wing Yan. "QM/MM studies of enzyme structure and function." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445894.

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7

Liou, Geoffrey. "Enzyme structure, function, and evolution in flavonoid biosynthesis." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122067.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Plant specialized metabolism is a key evolutionary adaptation that has enabled plants to migrate from water onto land and subsequently spread throughout terrestrial environments. Flavonoids are one particularly important class of plant specialized metabolites, playi

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8

Ljungberg, Liza. "Angiotensin-converting enzyme in cardiovascular function and dysfunction." Doctoral thesis, Linköpings universitet, Fysiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67215.

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Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system, converting angiotensin I to the vasoactive peptide angiotensin II, and degrading bradykinin. Angiotensin II is a multifunctional peptide, acting on a number of different tissues. A common genetic variation in the gene encoding ACE; ACE I/D polymorphism influences the level of ACE in the circulation, and has been linked to increased risk for cardiovascular disease. This thesis aimed to explore the connection between ACE and cardiovascular function and dysfunction. The impact of nicotine and nicotine metabolites

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9

Khan, Amjad. "NMR spectroscopy studies of enzyme function and inhibition." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:698d69c7-d4f1-4bc7-bf0b-3b9e7fb3a4fe.

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The work described in this Thesis focuses on the application of NMR spectroscopy methods in understanding the function and inhibition of two protein systems; these are ?-butyrobetaine hydroxylase (BBOX) and the bacterial potassium ion efflux (Kef) system. BBOX belongs to the super family of enzymes called the 2- oxoglutarate (2OG) and FeII dependent oxygenase and is involved in the biosynthesis of L-carnitine in humans and other prokaryotes. BBOX is a current drug target for the treatment of myocardial infarction. Kef is a ligandgated system that protects bacteria from toxic electrophilic spec

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10

Hamilton, Russell S. "DAROGAN : enzyme function prediction from multiple sequence alignments." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/14972.

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The function of an enzyme is often dependent on a few key functional residues and the principal objective of this project was to develop a novel function prediction system which takes advantage of this by comparing the conserved amino acids in known enzyme families to those in a putative enzyme. Multiple sequence alignments of well characterised enzyme families (with an E.C. number assigned) are used to create unordered sets of conserved functional residues, termed <i>Treads</i>. Comparison of a query proteins <i>Tread </i> to the reference <i>Treads</i> is undertaken by projecting them in mu

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11

Harris, Katharine Morse. "Studies of structure, function and mechanism in pyrimidine nucleotide biosynthesis." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2594.

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Thesis advisor: Evan R. Kantrowitz<br>Thesis advisor: Mary F. Roberts<br>Living organisms depend on enzymes for the synthesis using small molecule precursors of cellular building blocks. For example, the amino acid aspartate is synthesized in one step by the amination of oxaloacetate, an intermediate compound produced in the citric acid cycle, exclusively by means of an aminotransferase enzyme. Therefore, function of this aminotransferase is critical to produce the amino acid. In the Kantrowitz Lab, we seek to understand the molecular rational for the function of enzymes that control rates for

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12

Loftus, Katherine Marie. "Studies of the Structure and Function of E.coli Aspartate Transcarbamoylase." Thesis, Boston College, 2006. http://hdl.handle.net/2345/580.

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Thesis advisor: Evan R. Kantrowitz<br>E.coli Aspartate transcarbamoylase (ATCase) is the allosteric enzyme that catalyzes the committed step of the de novo pyrimidine biosynthesis pathway. ATCase facilitates the reaction between L-aspartate and carbamoyl phosphate to form N-carbamoyl-L-aspartate and inorganic phosphate. The holoenzyme is a dodecamer, consisting of two trimers of catalytic chains, and three dimers of regulatory chains. ATCase is regulated homotropically by its substrates, and heterotropically by the nucleotides ATP, CTP, and UTP. These nucleotides bind to the regulatory chains,

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13

Brokx, Stephen John. "Structure and function of enzyme I of the PTS." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0029/NQ63848.pdf.

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14

van, der Merwe Mariè. "Enzyme architecture and flexibility affect DNA topoisomerase I function." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-026-van_der_Merwe-Index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on July 29, 2008). Research advisor: Mary-Ann Bjornsti, Ph.D. Document formatted into pages (xiii, 175 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 161-175).

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15

Chiang, Ranyee Agnes. "Ligand-based perspectives on the evolution of enzyme function." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3324594.

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16

Alderson, Rosanna Grace. "Tracking the evolution of function in diverse enzyme superfamilies." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/10496.

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Tracking the evolution of function in enzyme superfamilies is key in understanding how important biological functions and mechanisms have evolved. New genes are being sequenced at a rate that far surpasses the ability of characterization by wet-lab techniques. Moreover, bioinformatics allows for the use of methods not amenable to wet lab experimentation. We now face a situation in which we are aware of the existence of many gene families but are ignorant of what they do and how they function. Even for families with many structurally and functionally characterized members, the prediction of fun

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17

Rees, D. "Studies on energy metabolism by phosphorous nuclear magnetic resonance." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370295.

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18

Charnock, Simon James. "Structure/function analysis of a family 10 glycosol hydrolase." Thesis, University of Newcastle upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262920.

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19

Carrasco, Rodríguez Patricia. "Study of the physiological function of carnitine palmitoyltransferase 1C enzyme." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/79172.

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Carnitine palmitoyl transferase 1 (CPT1) enzymes catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, thus facilitating the entry of long-chain fatty acids to the mitochondria, where they undergo β-oxidation. There are three isoforms: the liver isoform CPT1A (Esser, V. 1993), the muscle isoform CPT1B (Yamazaki, N. 1995) and the brain-specific isoform CPT1C (Price, N. 2002). CPT1A and CPT1B are localized in the outer mitochondrial membrane and are rate-limiting enzymes in fatty-acid β-oxidation. The CPT1C isoform, was first described in 2002, is expressed exclusively in the cent

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20

Luu, Luong. "Structure/function studies of hP450RAI, a retinoic acid metabolizing enzyme." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ36051.pdf.

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21

De, Ferrari Luna Luciana. "On combining collaborative and automated curation for enzyme function prediction." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7538.

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Data generation has vastly exceeded manual annotation in several areas of astronomy, biology, economy, geology, medicine and physics. At the same time, a public community of experts and hobbyists has developed around some of these disciplines thanks to open, editable web resources such as wikis and public annotation challenges. In this thesis I investigate under which conditions a combination of collaborative and automated curation could complete annotation tasks unattainable by human curators alone. My exemplar curation process is taken from the molecular biology domain: the association all e

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22

Chang, Cheng-Fu. "Structure-function and regulation studies of angiotensin-converting enzyme 2." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3122.

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23

Sharma, Narayan Prasad. "STRUCTURE/FUNCTION STUDIES ON METALLO-B- LACTAMASE ImiS FROM Aeromonas bv. sobria." Oxford, Ohio : Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1181583976.

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24

Stewart, Lorna. "The active transport systems of proline and potassium in Escherichia coli." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU006337.

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The transport systems for proline and potassium represent two of the active transport systems in Escherichia coli. They have further similarities that their transport may be utilized as a response to osmotic perturbations in the environment. The exact mechanism of transport had not been totally elucidated. The transport of proline had been assumed to operate as a proton symport and as such had been used as a model system when other transport systems were being investigated. This study has demonstrated that the major route of proline uptake through the proline permease 1 (PP1), operates as a Na

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25

Tuuttila, Ari. "Structure and function of MMP-2 and its inhibitor TIMP-2 /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4468-7/.

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26

Wen, Bo. "Analysis of human CYP3A4 structure-function relationships using photoaffinity labels /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8154.

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27

Lombardi, Olivia. "Investigating the role of mRNA capping enzyme in C-MYC function." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/4816aeec-c481-4494-9a07-56e74a83c08e.

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C-MYC is a transcription factor and a potent driver of many human cancers. In addition to regulating transcription, C-MYC promotes formation of the mRNA cap which is important for transcript maturation and translation. However, the mechanistic details of C-MYC-dependent mRNA capping are not fully understood. Since anti-cancer strategies to directly target the C-MYC protein have had limited success, enzymatic co-factors or effectors of C-MYC present attractive alternatives for therapeutic intervention of C-MYC-driven cancers. mRNA capping enzyme (CE) initiates mRNA cap formation by catalysing t

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28

Webb, Catherine Marie. "Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/33915.

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Polychlorinated biphenyls (PCBs) decrease thyroid function in rats and mice by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (UDP-GT), thereby increasing thyroxine (T4) clearance. This loss of T4 can lead to hypothyroidism. In this study, an assay was validated for measuring UDP-GT activity toward T4 in Japanese quail (Coturnix japonica). Then UDP-GT induction by Aroclor 1254 was evaluated in quail, and quail and mice were compared in their responses to Aroclor 1254. In Experiment 1, Japanese quail and Balb/c mice were dosed orally with vehicle or Aroclor

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29

Redelinghuys, Pierre. "Structure-function relationship of angiotensin-converting enzyme : glycosylation and domain-selectivity." Doctoral thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/3147.

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30

Raines, C. A. "Comparison of the effects of trypsin and chymotrypsin on thylakoid membrane function." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375465.

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31

Sheikh, Qaiser Iftikhar. "Exploring the structure and function of bacterial cytosine specific DNA methyltransferases using site-directed mutagenesis." Thesis, University of Sheffield, 2001. http://etheses.whiterose.ac.uk/10258/.

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Point mutations were engineered into the sequence of the multispecific DNA methyltransferase (Mtase) M. SPRI in motif IX, in order to mimic the corresponding motif IX of mono-specific Mtase. A similar approach was adopted to modify the sequence of the monospecific enzyme M. HhaI in motifs IX and X based on the available structure and as a consequence the enzyme regained methylation potential. It was thought that these changes might be sufficient to enable functional exchange of the target recognition domains (TRDs) between a mono- and a multispecific enzyme. However, insertion of various segme

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32

Kolb, Roman [Verfasser]. "beta-Sultams as Tools for the Study of Enzyme Function / Roman Kolb." München : Verlag Dr. Hut, 2014. http://d-nb.info/1058284762/34.

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33

Pretz, Monika Gyöngy. "Thermophilic P-loop transport ATPases enzyme function and energetics at high temperature /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/299141012.

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34

Snow, Juliette Elizabeth. "Investigation of the function of disproportionating enzyme in potato (Solanum tuberosum L.)." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/11421.

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In this study potato plant with lowered D-enzyme activity were investigated. It was found previously that lack of D-enzyme resulted in a reduction in the tuber yield of these plants and a delay in tuber sprouting. In this study the reduction in tuber yield was characterised further. It was found that tuber fresh weight per plant was reduced but percentage dry matter and starch content were unaltered. In addition, the extent of the reduction in fresh weight tuber yield was dependent on irradiance. Lack of D-enzyme also resulted in a delay in sugar accumulation in tuber during prolonged storage.

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35

Ma, Huan. "Aldolases for Enzymatic Carboligation : Directed Evolution and Enzyme Structure-Function Relationship Studies." Doctoral thesis, Uppsala universitet, Biokemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-266902.

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The research summarized in this thesis focuses on directed evolution and enzyme mechanism studies of two aldolases: 2-deoxyribose-5-phosphate aldolase (DERA) and fructose-6-phosphate aldolase (FSA). Aldolases are nature’s own catalysts for one of the most fundamental reactions in organic chemistry: the formation of new carbon-carbon bonds. In biological systems, aldol formation and cleavage reactions play central roles in sugar metabolism. In organic synthesis, aldolases attract great attention as environmentally friendly alternative for the synthesis of polyhydroxylated compounds in stereocon

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36

Rood, Jennifer E. (Jennifer Evelyn). "Structure and function of the human Poly(ADP-ribose) polymerase enzyme family." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81033.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, the enzymatic and cellular functions of many PARPs are unknown. This thesis presents work that seeks to characterize the enzymatic funct

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37

Ylianttila, M. (Mari). "Structure-function studies of the peroxisomal multifunctional enzyme type 2 (MFE-2)." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278968.

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Abstract Multifunctional enzyme type 2 (MFE-2) catalyses the second and the third reactions in the eukaryotic peroxisomal β-oxidation cycle, which degrades fatty acids by removing a two-carbon unit per each cycle. In addition to the 2-enoyl-CoA hydratase 2 and (3R)-hydroxyacyl-CoA dehydrogenase activities, mammalian MFE-2 has also a sterol carrier protein type 2-like (SCP-2L) domain. In contrast, yeast MFE-2 has two (3R)-hydroxyacyl-CoA dehydrogenases, one 2-enoyl-CoA hydratase 2 and no SCP-2L domain. The physiological roles of yeast (3R)-hydroxyacyl-CoA dehydrogenases (A and B) were tested

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38

Martínez, Cuesta Sergio. "The chemistry and evolution of enzyme function : isomerases as a case study." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/246994.

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The study of the evolution of proteins has been traditionally undertaken from a sequence and structural point of view. However any attempt to understand how protein function changes during evolution benefits from consistent definitions of function and robust approaches to quantitatively compare them. The function of enzymes is described as their ability to catalyse biochemical reactions according to the Enzyme Commission (EC). This dissertation explores aspects of the chemistry and evolution of a small class of enzymes catalysing geometrical and structural rearrangements between isomers, the i

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39

Sikora, Aneta E. "Structure-function analysis of a multifunctional enzyme using the atomic force microscope." Thesis, University of Portsmouth, 2010. https://researchportal.port.ac.uk/portal/en/theses/structurefunction-analysis-of-a-multifunctional-enzyme-using-the-atomic-force-microscope(fdbd2065-c230-4eba-a7cd-94cbb1bb9e16).html.

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The type I R-M enzyme EcoR124I is a multifunctional, multisubunit molecular motor with the ability to self-assemble. In the presence of hydrophobic compounds, subunit disassembly has been observed leading to the possibility of using the enzyme as a nanoactuator in toxicity biosensors. A better understanding of single molecule interactions between the subunits has been investigated using atomic force microscopy (AFM), a powerful tool for measuring forces and dynamics between single molecules with a picoNewton sensitivity. AFM imaging of DNA fragments with a single recognition binding site for E

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40

Hidestrand, Mats. "Structure and function of hepatic cytochromes P450 - implications for drug development /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-418-6/.

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41

Millar, Timothy Marc. "Novel aspects of the activity and function of xanthine oxidase." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311326.

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42

Chu, Yuanyuan. "Role of the ubiquitin-editing enzyme A20 in B cell function and disease." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-151826.

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43

Gross, Martin. "The tryptophan residues of mitochondrial creatine kinase : roles in enzyme structure and function /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10719.

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44

Sliz, Piotr. "Structure, function and interactions of enzyme IIA from the phosphoenolpyruvate, lactose phosphotransferase system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ53658.pdf.

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45

Carter, Lisa, Devaiah P. Shivakumar, and Cecelia A. McIntosh. "Mutagenesis of a Flavonol- 3-O-Glucosyltransferase and the Effect on Enzyme Function." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/349.

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Flavonoids are an important group of secondary metabolites found in plants and have a wide variety of properties. Some play a role in fl ower pigmentation, while others have antimicrobial properties. Glucosylation is an important modifi cation of fl avonoids and is mediated by glucosyltransferases. In this process, the enzyme transfers glucose from UDP-glucose to a specifi c position on the fl avonoid. Previous study from the lab characterized a glucosyltransferase from C. paradisi that is fl avonol specifi c. In this study an attempt has been made to study the structure and function of this f

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46

Myllykoski, M. (Matti). "Structure and function of the myelin enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526201375.

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Abstract The myelin sheath is a crucial component of vertebrate nervous systems. Myelin is formed as the plasma membrane of a glial cell is wrapped around a neuronal axon. The presence of myelin enables the fast transmission of neuronal impulses, and degradation or dysfunction of myelin results in severe neurological symptoms. Molecular composition of myelin is unique, and many myelin proteins are not present elsewhere in the body. A myelin enzyme, 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase), is found in specific regions within the myelin sheath and is one of the most abundant protei

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47

Haapalainen, A. (Antti). "Structure-function studies of the mammalian peroxisomal multifunctional enzyme type 2 (MFE-2)." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514268385.

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Abstract Mammalian peroxisomes contain two parallel multifunctional enzymes (MFE), MFE type 1 and MFE type 2 (MFE-2), which are responsible for the degradation of fatty acids. They both catalyze the second and third reactions of the β-oxidation pathway, but through reciprocal stereochemical courses. MFE-2 possesses (2E)-enoyl-CoA hydratase-2 and (3R)-hydroxyacyl-CoA dehydrogenase activities. In addition, the carboxy-terminal part is similar to the sterol carrier protein type 2 (SCP-2). The purpose of this work was to study the structure-function relationship of functional domains of mammalia

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48

Just, Sissy [Verfasser]. "T cell specific function of the deubiquitinating enzyme A20 in murine listeriosis / Sissy Just." Magdeburg : Universitätsbibliothek, 2017. http://d-nb.info/1128726459/34.

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49

McIntosh, Cecilia A. "Structure and Function of Flavonoid Glucosyltransferases: Using a Specific Grapefruit Enzyme as a Model." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/355.

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Glucosyltransferases (GTs) are enzymes that enable transfer of glucose from an activated donor (UDP-glucose) to the acceptor substrates. A flavonol specific glucosyltransferase cloned from Citrus paradisi has strict substrate and regiospecificity (Cp3OGT). The amino acid sequence of Cp3OGT was aligned with a purported anthocyanin GT from Clitorea ternatea and a GT from Vitis vinifera that can glucosylate both flavonols and anthocyanidins. Using homology modeling to identify candidate regions followed by site directed mutagenesis, three double mutations of Cp3OGT were made. Biochemical analysis

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50

McIntosh, Cecilia A. "Structure and Function of Flavonoid Glucosyltransferases: Using a specific Grapefruit Enzyme as a Model." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/369.

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