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Journal articles on the topic 'Eosin molecule'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Hari, Durga Prasad, and Burkhard König. "Synthetic applications of eosin Y in photoredox catalysis." Chem. Commun. 50, no. 51 (2014): 6688–99. http://dx.doi.org/10.1039/c4cc00751d.

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Jia, Tiantian, Molly M. J. Li, Lin Ye, et al. "The remarkable activity and stability of a dye-sensitized single molecular layer MoS2ensemble for photocatalytic hydrogen production." Chemical Communications 51, no. 70 (2015): 13496–99. http://dx.doi.org/10.1039/c5cc03871e.

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Horie, T., T. Mizuma, S. Kasai, and S. Awazu. "Conformational change in plasma albumin due to interaction with isolated rat hepatocyte." American Journal of Physiology-Gastrointestinal and Liver Physiology 254, no. 4 (1988): G465—G470. http://dx.doi.org/10.1152/ajpgi.1988.254.4.g465.

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The electron spin resonance spectroscopy of 4-isothiocyanato-tempo labeled to bovine serum albumin (BSA) and the absorption spectroscopy of eosin maleimide labeled to BSA in the isolated rat hepatocyte suspension indicate conformational change occurring in the albumin molecule during interaction with the hepatocellular membrane. The conformational change in the albumin molecule may possibly accelerate the dissociation of albumin-organic anion complexes at the surface of the liver cell. The conformational change in the albumin molecule may explain in part the mechanism of albumin-mediated hepat

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4

Lynch, Pauline G., Huw Richards, and Kristin L. Wustholz. "Unraveling the Excited-State Dynamics of Eosin Y Photosensitizers Using Single-Molecule Spectroscopy." Journal of Physical Chemistry A 123, no. 13 (2019): 2592–600. http://dx.doi.org/10.1021/acs.jpca.9b00409.

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Kopera, Kelly M., Harrison G. Tuckman, Grayson R. Hoy, and Kristin L. Wustholz. "Origin of Kinetic Dispersion in Eosin-Sensitized TiO₂: Insights from Single-Molecule Spectroscopy." Journal of Physical Chemistry C 125, no. 43 (2021): 23634–45. http://dx.doi.org/10.1021/acs.jpcc.1c07597.

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Klovak, V., L. Nechpai, S. Lelyushok, and S. Kulichenko. "FLUORESCENCE CHARACTERISTICS OF FLUORESCEIN AND EOSIN Y SOLUTIONS IN WATER-MICELLAR SURFACTANT MEDIA." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1 (57) (2020): 23–26. http://dx.doi.org/10.17721/1728-2209.2020.1(57).6.

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The effect of cationic, anionic and nonionic surfactants on the fluorescence properties of fluorescein and eosin Y aqueous solutions has been investigated. It has been found that sodium dodecyl sulfate does not affect the position of the maximum wavelengths of solutions of fluorescein and eosin Y in the study of the effect of an anionic surfactant on the fluorescence emission intensity of dyes. The intensity of the signal of the dye solutions when changing the concentration of anionic surfactant changes little. As the concentration of non-ionic surfactant increases, the fluorescence emission i

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Kooli, F., Y. Liu, K. Hbaieb, O. Y. Ching, and R. Al-Faze. "Characterization of organo-kenyaites: thermal stability and their effects on eosin removal characteristics." Clay Minerals 53, no. 1 (2018): 91–104. http://dx.doi.org/10.1180/clm.2018.7.

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ABSTRACTOrgano-kenyaites were prepared from a cetyltrimethylammonium hydroxide (C16TMAOH) solution and solid sodium kenyaite (Na2Si22O45.10H2O) mixture. The effect of the initial cetyltrimethylammonium solution on the structure of the intercalated materials was investigated by CHN analyses, X-ray diffraction (XRD), thermogravimetric analysis, SEM, and 29Si and 13C solid NMR techniques. For C16TMAOH concentration 0.25 mM, the Na+ cations were fully exchanged. Initial C16TMAOH concentrations higher than 0.25 mM had little effect on the intercalated amount of C16TMA+ cations. The organic cations

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Cervantes, Cesar Elpidio Rodríguez, and Clara Alba Betancourt. "Effect of Metformin on Adipose Tissue Degeneration During Obesity." SVOA Medical Research 1, no. 1 (2023): 01–06. http://dx.doi.org/10.58624/svoamr.2023.01.001.

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Obesity is associated with an increased inflammation involved in the development of atherosclerosis and insulin resistance. Macrophages are key in the genesis of these processes. Obesity induces macrophage accumulation in adipose tissue, they produce many of the inflammatory molecules secreted by adipose tissue like TNF-α, interleukins (IL-1β, IL-6, IL-8), as well as acute phase proteins such as haptoglobin (Hp), PAI-1 and C-reactive protein. The presence of these molecules in obesity relates this pathology to various inflammation degrees.The analysis of histological sections obtained from rab

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Cesar, Elpidio Rodríguez Cervantes, and Alba Betancourt Clara. "10.58624/SVOAMR.2023.01.001." SVOA Medical Research 1, no. 1 (2023): 01–06. https://doi.org/10.5281/zenodo.8237762.

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Obesity is associated with an increased inflammation involved in the development of atherosclerosis and insulin resistance. Macrophages are key in the genesis of these processes. Obesity induces macrophage accumulation in adipose tissue, they produce many of the inflammatory molecules secreted by adipose tissue like TNF-α, interleukins (IL-1β, IL-6, IL-8), as well as acute phase proteins such as haptoglobin (Hp), PAI-1 and C-reactive protein. The presence of these molecules in obesity relates this pathology to various inflammation degrees.The analysis of histological sections obtain

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Cesar, Elpidio Rodríguez Cervantes, and Alba Betancourt Clara. "Effect of Metformin on Adipose Tissue Degeneration During Obesity." SVOA Medical Research 1, no. 1 (2023): 01–06. https://doi.org/10.58624/SVOAMR.2023.01.001.

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Obesity is associated with an increased inflammation involved in the development of atherosclerosis and insulin resistance. Macrophages are key in the genesis of these processes. Obesity induces macrophage accumulation in adipose tissue, they produce many of the inflammatory molecules secreted by adipose tissue like TNF-α, interleukins (IL-1β, IL-6, IL-8), as well as acute phase proteins such as haptoglobin (Hp), PAI-1 and C-reactive protein. The presence of these molecules in obesity relates this pathology to various inflammation degrees. The analysis of histological sections obtai

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11

AlMuraikhi, Nihal, Dalia Ali, Radhakrishnan Vishnubalaji, et al. "Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells." Stem Cells International 2019 (August 22, 2019): 1–12. http://dx.doi.org/10.1155/2019/3041262.

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Background. Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. Methods. Stem cell signaling small molecule library functional screen was performed employing human bone marrow skeletal (mesenchymal) stem cells (hBMSCs). Alkaline phosphatase (ALP) activity and formation of mineralized matrix visualized by Alizarin red staining were employed as markers for osteoblastic differentiation. Global gene expressio

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Chopp, Michael, Yi Li, Ning Jiang, Rui Lan Zhang, and Jonathan Prostak. "Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain." Journal of Cerebral Blood Flow & Metabolism 16, no. 4 (1996): 578–84. http://dx.doi.org/10.1097/00004647-199607000-00007.

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We tested the hypothesis that treatment of transient focal cerebral ischemia in rat with antibodies directed against adhesion molecules reduces apoptosis. Rats (n = 31) were subjected to 2 h of middle cerebral artery (MCA) occlusion induced by intraluminal insertion of a nylon monofilament into the internal carotid artery. Upon reperfusion, animals were treated with monoclonal antibodies directed against intercellular adhesion molecule (ICAM)-1) (n = 8) or integrin CD11b/CD18 (n = 10), or administered IgG1 as a control (n = 13). At 48 h after ischemia, animals were killed and the brains analyz

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Kim, Soo-Hyeon, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Hee-Myung Park, and Jung-Hyang Sur. "Increased p63 expression in canine perianal gland tumours." Journal of Veterinary Research 62, no. 2 (2018): 229–35. http://dx.doi.org/10.2478/jvetres-2018-0020.

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AbstractIntroductionp63 is a homologous molecule of p53 and was recently identified as playing important roles in several key cellular processes, including epithelial development and proliferation. Since then, several studies have demonstrated altered p63 expression in various cancers of epithelial origin. Canine perianal gland tumour is one of the most common skin neoplasms in dogs; however, the molecular characteristics of this tumour remain poorly understood. The objective of the present study was to analyse and compare the expression of p63 in canine perianal gland adenomas and carcinomas.

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Bin Satter, Khaled, Zach Ramsey, Paul M. H. Tran, et al. "Development of a Single Molecule Counting Assay to Differentiate Chromophobe Renal Cancer and Oncocytoma in Clinics." Cancers 14, no. 13 (2022): 3242. http://dx.doi.org/10.3390/cancers14133242.

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Malignant chromophobe renal cancer (chRCC) and benign oncocytoma (RO) are two renal tumor types difficult to differentiate using histology and immunohistochemistry-based methods because of their similarity in appearance. We previously developed a transcriptomics-based classification pipeline with “Chromophobe-Oncocytoma Gene Signature” (COGS) on a single-molecule counting platform. Renal cancer patients (n = 32, chRCC = 17, RO = 15) were recruited from Augusta University Medical Center (AUMC). Formalin-fixed paraffin-embedded (FFPE) blocks from their excised tumors were collected. We created a

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15

Liu, Yahong, Longfei Miao, Yuying Guo, and Hongqi Tian. "Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003." Oxidative Medicine and Cellular Longevity 2021 (February 20, 2021): 1–11. http://dx.doi.org/10.1155/2021/6683836.

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Amifostine is a radioprotector with high efficacy but poor safety, short half-life, no oral formulation, and poor compliance, which limits its application. With the increasing risk of exposure to radiation, the development of new radioprotective agents is critical. We previously synthesized a new amifostine derivative, the small molecule compound HL-003. In this study, we focused on evaluating the radioprotective properties of HL-003. Using the in vitro 2,2-diphenyl-1-picrylhydrazyl assay, we initially confirmed HL-003 as a strong antioxidant and demonstrated that its free radical scavenging a

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Cher, Jonathon Z. B., Moeed Akbar, Susan Kitson, et al. "Alarmins in Frozen Shoulder: A Molecular Association Between Inflammation and Pain." American Journal of Sports Medicine 46, no. 3 (2017): 671–78. http://dx.doi.org/10.1177/0363546517741127.

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Background: The pathophysiological mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear. Alarmins (also known as danger signals) are endogenous molecules that are released into the extracellular milieu after infection or tissue injury and that signal cell and tissue damage. Purpose: To investigate whether the presence of alarmins is higher in patients with idiopathic frozen shoulder than in control subjects. Study Design: Controlled laboratory study. Methods: Shoulder capsule samples were collected from 10 patients

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Pankratov, A. N., I. M. Uchaeva, S. M. Rogacheva, and E. V. Volkova. "Spatial and Electronic Structure of the Pyrene Molecule, Tripaflavin Cation and Eosin Anions As a Prerequisite for Interpreting Their Solid-phase Fluorescence." Chemistry. Biology. Ecology 16, no. 4 (2016): 393–98. http://dx.doi.org/10.18500/1816-9775-2016-16-4-393-398.

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Liu, Zhen, Tong Chen, Haitao Niu, et al. "The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/1365257.

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Epidemiological studies have identified hyperuricemia as an independent risk factor for cardiovascular disease. However, the mechanism whereby hyperuricemia causes atherosclerosis remains unclear. The objective of the study was to establish a new rat model of hyperuricemia-induced atherosclerosis. Wistar-Kyoto rats were randomly allocated to either a normal diet (ND), high-fat diet (HFD), or high-adenine diet (HAD), followed by sacrifice 4, 8, or 12 weeks later. Serum uric acid and lipid levels were analyzed, pathologic changes in the aorta were observed by hematoxylin and eosin staining, and

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Kovačić, Sanja, Stjepan Pepeljnjak, Zdravko Petrinec, and Maja Klarić. "Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus Carpio L.)." Archives of Industrial Hygiene and Toxicology 60, no. 4 (2009): 419–26. http://dx.doi.org/10.2478/10004-1254-60-2009-1974.

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Fumonisin B1 Neurotoxicity in Young Carp (Cyprinus CarpioL.)For years scientists have suspected that the environment plays a role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Mycotoxin fumonisin B1(FB1) is produced by severalFusariumspecies, mainly byFusarium verticilioides, which is one of the most common fungi associated with corn worldwide. Fumonisins are known to cause equine leukoencephalomalacia, a disease associated with the consumption of corn-based feeds contaminated with FB1. Here we have reported chronic experimental toxicos

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Blanco, Rancés, Mercedes Cedeño, Narjara González, Reynier Rodríguez, Javier Sánchez, and Enrique Rengifo. "Phenotypic heterogeneity in the NCI-H125 cell line affects biological activity using the epidermal growth factor receptor as target / Fenotipska heterogenost u staničnoj liniji NCI-H125 utječe na biološku aktivnost na receptore za epidermalni faktor rasta." Acta Pharmaceutica 62, no. 4 (2012): 581–91. http://dx.doi.org/10.2478/v10007-012-0038-6.

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We evaluated the influence of some morphological changes of the NCI-H125 cell line in surface expression of the epidermal growth factor receptor (EGFR) and their impact on some biological activity assays using this molecule as target. Hematoxylin and eosin (H/E) staining, light microscopy immunocytochemistry, flow cytometric antibody-receptor binding test, cell viability determination and cell cycle analysis were performed. Phenotypic changes and inconsistency in EGFR expression were detected in NCI-H125 cell cultures. A significant reduction in the growth rate, mainly characterized by cell cy

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Mamajanov, Irena, Melina Caudan, and Tony Z. Jia. "Protoenzymes: The Case of Hyperbranched Polymer-Scaffolded ZnS Nanocrystals." Life 10, no. 8 (2020): 150. http://dx.doi.org/10.3390/life10080150.

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Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes: hyperbranched polymer-scaffolded metal-sulfide nanocrystals. Hyperbranched polyethyleneimine (HyPEI) and glycerol citrate polymer-supported ZnS nanocrystals (NCs) are formed in a simple process. Transmission electron microscopy (TEM) analyses of HyPEI-supported NCs reveal spherical particles with

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Maurya, Shashi Bhal, Devi Charan Shetty, Ajit Singh Rathore, Saurabh Juneja, Anshi Jain, and Akanksha Banga. "Immunolocalization of epithelial cell adhesion molecule and matrix metalloproteinase-9 in oral epithelial dysplasia and oral squamous cell carcinoma." Journal of Cancer Research and Therapeutics 19, no. 7 (2023): 1775–80. http://dx.doi.org/10.4103/jcrt.jcrt_1012_21.

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ABSTRACT Introduction: Cancers are complex tissues composed of multiple distinct cell types that participate in heterotypic interactions with one another. Physiologically cell-to-cell contacts formed by dense populations of normal cells operate to suppress further cell proliferation. Objectives: The objective of the study is to evaluate and compare the immunoexpression of matrix metalloproteinase-9 (MMP-9) and epithelial cell adhesion molecule (EpCAM) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) and to hypothesize their role in the progression in varying grades of

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Sahiner, Mehtap, Zhi Tian, Diane Allen-Gipson, Aydin K. Sunol, and Nurettin Sahiner. "Natural Molecule-Derived Nanogels from Hematoxylin and l-lysine for Biomedical Use with Antimicrobial Properties." International Journal of Molecular Sciences 26, no. 1 (2024): 138. https://doi.org/10.3390/ijms26010138.

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Hematoxylin (HT) is a natural staining dye used in histopathology, often combined with Eosin for H&E staining. A poly(hematoxylin-co-l-lysine) (p(HT-co-l)) nanonetwork was synthesized through a one-step Mannich condensation reaction using formaldehyde as a linking agent. The resulting p(HT-co-l) nanogels had an average size of about 200 nm and exhibited a smooth surface and desirable functional groups such as -OH, -NH2, and -COOH, as recognized by FT-IR analysis. The isoelectric point (IEP) of the p(HT-co-l) nanogel was determined as pH 7.9, close to physiological environments, despite HT

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Liu, Kang, Hang Yang, Rong Xiong, et al. "Generation and characterization of mAb 61H9 against junctional adhesion molecule-a with potent antitumor activity." PeerJ 12 (March 14, 2024): e17088. http://dx.doi.org/10.7717/peerj.17088.

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Junctional adhesion molecule-A (JAM-A) is an adhesion molecule that exists on the surface of certain types of cells, including white blood cells, endothelial cells, and dendritic cells. In this study, the cDNA sequences of JAM-A-Fc were chemically synthesized with optimization for mammalian expression. Afterward, we analyzed JAM-A protein expression through transient transfection in HEK293 cell lines. Mice were immunized with JAM-A-Fc protein, and hybridoma was prepared by fusing myeloma cells and mouse spleen cells. Antibodies were purified from the hybridoma supernatant and four monoclonal s

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Santos, João Campos, Carla Cruz Marques, Maria Conceição Baptista, et al. "Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant Molecule on Bovine Sperm Function and Embryo Production." Animals 12, no. 7 (2022): 804. http://dx.doi.org/10.3390/ani12070804.

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Sperm cells are particularly vulnerable to reactive oxygen species (ROS), impairing their fertilizing ability. Our objective was to study the effect of a novel mitochondrial-directed antioxidant, AntiOxBEN2, on bovine sperm function. This antioxidant was added to the semen capacitation medium (CAP), during the swim-up process, and to the fertilization medium (FERT) during the co-incubation of matured oocytes and capacitated spermatozoa, in concentrations of 0 (control), 1, and 10 µM. After the swim-up, sperm motility (CASA and visual analysis), vitality (eosin-nigrosin), mitochondrial membrane

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Asefy, Zahra, Sirus Hoseinnejhad, Sanam Dolati, et al. "miR-515-5p and Notch1 as New Diagnostic Markers of Hepatocellular Carcinoma." Avicenna Journal of Medical Biochemistry 7, no. 1 (2019): 4–8. http://dx.doi.org/10.34172/ajmb.2019.02.

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Background: Modifications of miRNA expression have been related to various types of cancers including hepatocellular carcinoma (HCC). miRNAs directly act as repressors of gene expression, as they reside in fragile sites, as well as cancer-related genomic regions. Notch signaling is a conserved evolutionary pathway that controls cell functions. The dysregulation of this pathway leads to different diseases such as cancer. Objectives: This study aimed to investigate the role of miR-515-5p and Notch1 as new diagnostic markers in HCC. Methods: Forty formalin fixed paraffin embedded (FFPE) autopsy b

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Núñez Figueredo, Yanier, Jeney Ramírez-Sanchez, Gisele Hansel, et al. "Therapeutic potential of the novel hybrid molecule JM-20 against focal cortical ischemia in rats." Journal of Pharmacy & Pharmacognosy Research 4, no. 1 (2016): 153–58. http://dx.doi.org/10.56499/jppres16.126_4.4.153.

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Context: Despite the great mortality and morbidity of stroke, treatment options remain limited. We previously showed that JM-20, a novel synthetic molecule, possessed a strong neuroprotective effect in rats subjected to transient middle cerebral artery occlusion. However, to verify the robustness of the pre-clinical neuroprotective effects of JM-20 to get good prognosis in the translation to the clinic, it is necessary to use other experimental models of brain ischemia. Aims: To evaluate the neuroprotective effects of JM-20 following the onset of permanent focal cerebral ischemia induced in ra

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Wang, Liang, Xiaoqian Shang, Xinwei Qi, et al. "Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis." Disease Markers 2020 (May 25, 2020): 1–8. http://dx.doi.org/10.1155/2020/2509454.

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Background. Macrophages are important immune cells involved in Mycobacterium tuberculosis (M.tb) infection. To further investigate the degree of disease development in patients with spinal tuberculosis (TB), we conducted research on macrophage polarization. Methods. Thirty-six patients with spinal TB and twenty-five healthy controls were enrolled in this study. The specific morphology of tuberculous granuloma in spinal tissue was observed by hematoxylin-eosin (H&E) staining. The presence and distribution of bacilli were observed by Ziehl-Neelsen (ZN) staining. Macrophage-specific molecule

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Moskaeva, Elena, Kirill Ostrovskiy, Sergey Shekhovtsov, and Nikolay Mchedlov-Petrossyan. "Transmittance of electronic effects in the fluorescein molecule: nitro and amino groups in the phthalic acid residue." Kharkov University Bulletin Chemical Series, no. 36 (February 17, 2021): 24–32. http://dx.doi.org/10.26565/2220-637x-2021-36-05.

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This paper is aimed to estimate the transmittance of the electronic effects in the fluorescein molecule between the phthalic acid residue and the xanthene moiety. Despite the almost orthogonal orientation of the latter with respect to the rest of the molecule, some influence of substituents in this 9-aryl ring on the dissociation of the hydroxyl group of the hydroxyxanthene cannot be ruled out. In order to reveal this (possible) effect, we blocked the carboxylic group via esterification. The reason of using dimethyl sulfoxide as solvent was the high Hammett’s “rho” constant for phenolic group.

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Mehrhoff, Farida, Keanna G. Theobalt, Alla G. Barry, and Robert Hillard. "Histopathological evaluation of geriatric ophthalmic veins: A cadaveric study." Journal of Clinical Ophthalmology and Research 12, no. 3 (2024): 191–97. http://dx.doi.org/10.4103/jcor.jcor_120_24.

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Context: The ophthalmic vein (OV) has become a source of increasing curiosity since many aspects of vascular surgery of the orbit have become feasible. At the same time, histochemical analysis of veins, in general, tends to skip the OV. Moreover, age-related changes in the OVs remain untouched. Aims: Our research explores features of aging in the OV. Settings and Design: We immunohistochemically evaluated the superior and inferior OVs in 49 orbits of 28 formalin-embalmed human cadavers (age 77.86 ± 13.38) without visible vascular malformations. Materials and Methods: Specimens were stained by

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Otsubo, Chieko, Zhanna Mussazhanova, Hirokazu Kurohama, et al. "A New Indicator to Differentiate Thyroid Follicular Inclusions in Cervical Lymph Nodes from Patients with Thyroid Cancer." International Journal of Molecular Sciences 24, no. 1 (2022): 490. http://dx.doi.org/10.3390/ijms24010490.

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Nodal metastasis is crucial for determining the stage of well-differentiated thyroid cancer (WTC) in patients older than 55. Well-formed thyroid follicular inclusions (TFIs) are occasionally encountered in the cervical lymph nodes (LNs) of patients with papillary thyroid carcinoma (PTC), and it is difficult to determine whether they are true nodal metastases or ectopic thyroid tissues (ETT). This study aimed to elucidate the impact of the expression of the DNA damage response molecule TP53-binding protein 1 (53BP1) using immunofluorescence (IF) as a biomarker to differentiate TFIs in cervical

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Sun, Changzhen, Jianv Wang, Tong Xia, et al. "Mitochondrion-Targeted NIR Therapeutic Agent Suppresses Melanoma by Inducing Apoptosis and Cell Cycle Arrest via E2F/Cyclin/CDK Pathway." Pharmaceuticals 15, no. 12 (2022): 1589. http://dx.doi.org/10.3390/ph15121589.

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Malignant melanoma is the most fatal form of skin cancer worldwide, and earlier diagnosis and more effective therapies are required to improve prognosis. As a possible solution, near-infrared fluorescent heptamethine cyanine dyes have been shown to be useful for tumor diagnosis and treatment. Here, we synthesized a novel theranostic agent, IR-817, a multifunctional bioactive small-molecule that has near-infrared emission, targets mitochondria in cancer cells, and has selective anti-cancer effects. In in vitro experiments, IR-817 preferentially accumulated in melanoma cells through organic anio

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Zheng, Jia-San, Jing-Nie, Ting-Ting Zhu, Hong-Ri Ruan, Xue-Wei, and Rui-Wu. "Screening of early diagnostic markers of gentamicin-induced acute kidney injury in canines." Journal of Veterinary Research 63, no. 3 (2019): 405–11. http://dx.doi.org/10.2478/jvetres-2019-0048.

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Abstract Introduction The value of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), and liver-type fatty acid binding protein (L-FABP) was assessed in early diagnosis of gentamicin-induced acute kidney injury (AKI) in dogs. Material and Methods Subcutaneous gentamicin injection in 16 healthy adult beagles made the AKI model. Blood was sampled every 6 h to detect NGAL, Kim-1, L-FABP, and serum creatinine (SCr) concentrations. Kidney tissue of two dogs was taken before the injection, as soon as SCr was elevated (78 μmol/L), and when it had risen to 1.5 times t

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Sahiner, Mehtap, Aydin K. Sunol, and Nurettin Sahiner. "Cell Staining Microgels Derived from a Natural Phenolic Dye: Hematoxylin Has Intriguing Biomedical Potential." Pharmaceutics 16, no. 1 (2024): 147. http://dx.doi.org/10.3390/pharmaceutics16010147.

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Hematoxylin (HT) as a natural phenolic dye compound is generally used together with eosin (E) dye as H&E in the histological staining of tissues. Here, we report for the first time the polymeric particle preparation from HT as poly(Hematoxylin) ((p(HT)) microgels via microemulsion method in a one-step using a benign crosslinker, glycerol diglycidyl ether (GDE). P(HT) microgels are about 10 µm and spherical in shape with a zeta potential value of −34.6 ± 2.8 mV and an isoelectric point (IEP) of pH 1.79. Interestingly, fluorescence properties of HT molecules were retained upon microgel forma

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Mix, Madison R., Vanessa Y. Ruiz, April M. Huseby Kelcher, Slobodan I. Macura, Prasanna K. Mishra, and Aaron J. Johnson. "Virus antigen-specific CD8 T cells contribute to brain atrophy during Theiler’s murine encephalomyelitis virus (TMEV) infection of the CNS." Journal of Immunology 200, no. 1_Supplement (2018): 61.2. http://dx.doi.org/10.4049/jimmunol.200.supp.61.2.

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Abstract Brain atrophy is a central feature of numerous neurological diseases for which the contribution of immune cells remains poorly defined. For example, in human multiple sclerosis, clonally expanded CD8 T cells have been observed in proximity to lesions, but their role in mediating brain atrophy has yet to be elucidated. This study aims to define how antigen-specific CD8 T cells contribute to brain atrophy in the TMEV model of neuroinflammation. Specific MHC class I haplotypes have been shown to dictate neuropathology and functional outcomes in mice following intracranial infection with

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Bayindala, He Huang, Song Gao, and Xinjian Xu. "Echinococcus multilocularis induces surface high expression of inhibitory killer immunoglobulin‐like receptor on natural killer cells." Allergologia et Immunopathologia 49, no. 5 (2021): 78–86. http://dx.doi.org/10.15586/aei.v49i5.465.

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Alveolar echinococcosis (AE) is a malignant and fatal parasitic disease caused by the larvae of Echinococcus multilocularis (E. multilocularis), which inhibits the activity and proliferation of natural killer (NK) cells. In this study, the functional alteration of hepatic NK cells and their related molecules were studied. The AE-infected patient’s tissue was fixed with formalin, embedded in paraffin, and stained with Masson’s trichrome or hematoxylin and eosin (H&E). Single cells from AE-infected patient or E. multilocularis-infected mice were blocked with Fc-receptor (FcR), and stained wi

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Wang, Jianwei, Quancheng Cheng, Jinyu Fang, et al. "A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats." Antioxidants 10, no. 12 (2021): 1933. http://dx.doi.org/10.3390/antiox10121933.

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As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (•OH) and peroxynitrite (ONOO•) in cells, reducing oxidative stress damage. The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective mechanism of hydrogen gas on hepatocytes by observing the expression of uncoupling protein 2 (UCP2) in liver tissue. Here, 32 rats were divided into four groups: the control group, CCl4 group, H2 (hydrogen gas) g

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Lee, Song Yi, Suyeong Nam, Sungyun Kim, et al. "Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models." Evidence-Based Complementary and Alternative Medicine 2018 (August 19, 2018): 1–8. http://dx.doi.org/10.1155/2018/3610494.

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A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower t

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Cao, Song, Dexin Zhang, Jie Yuan, et al. "Inflammatory cytokine expression in the skin of patients with postherpetic neuralgia." Journal of International Medical Research 48, no. 8 (2020): 030006052092958. http://dx.doi.org/10.1177/0300060520929582.

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Objective To assess the expression of inflammatory cytokines in the affected and normal skin of postherpetic neuralgia (PHN) patients. Methods Affected skin and normal skin samples were collected from PHN patients. Inflammatory cell infiltration in the dermis were evaluated by hematoxylin-eosin (HE) staining. A human inflammatory protein array containing 40 cytokines was used to assess expression differences between PHN and control skin. Enzyme linked immunosorbent assay (ELISA) kits were used to confirm cytokine expression in 10 PHN patients. Results HE staining showed that the epidermis of P

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Prabha, Vijay, Tanushree Gupta, Siftjit Kaur, Navchetan Kaur, Sushila Kala, and Arvind Singh. "Isolation of a spermatozoal immobilization factor from Staphylococcus aureus filtrates." Canadian Journal of Microbiology 55, no. 7 (2009): 874–78. http://dx.doi.org/10.1139/w09-032.

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Staphylococcus aureus isolated from the cervix of an infertile woman was found to cause complete immobilization of human spermatozoa in vitro. Only the cell culture and cell-free supernatant showed immobilization activity, indicating that the sperm immobilization factor might be released extracellularly by the organism because no activity was observed with the washed cells. Heat treatment of the supernatant at 60 °C for 10 min waived its immobilizing activity, indicating that the active component may be a protein. The bioactive molecule from the supernatant was purified to homogeneity by ammon

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Delcanale, Pietro, Manuela Maria Alampi, Andrea Mussini, et al. "A Photoactive Supramolecular Complex Targeting PD-L1 Reveals a Weak Correlation between Photoactivation Efficiency and Receptor Expression Levels in Non-Small-Cell Lung Cancer Tumor Models." Pharmaceutics 15, no. 12 (2023): 2776. http://dx.doi.org/10.3390/pharmaceutics15122776.

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Photo-immunotherapy uses antibodies conjugated to photosensitizers to produce nanostructured constructs endowed with targeting properties and photo-inactivation capabilities towards tumor cells. The superficial receptor density on cancer cells is considered a determining factor for the efficacy of the photodynamic treatment. In this work, we propose the use of a photoactive conjugate that consists of the clinical grade PD-L1-binding monoclonal antibody Atezolizumab, covalently linked to either the well-known photosensitizer eosin or the fluorescent probe Alexa647. Using single-molecule localiz

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Zhang, Yuzhu, Huachao Li, Hongyan Zhang та ін. "A small molecule LN435a targeting TGFβR1 exerts promising antitumor effects on breast cancer." Journal of Clinical Oncology 39, № 15_suppl (2021): e15069-e15069. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15069.

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e15069 Background: Breast cancer has overtaken lung cancer as the most diagnosed cancer. Despite conventional treatment, metastases occur in 20-30% of patients, resulting in death. This study aims to screen of effective drugs by metastatic patient-derived organoid and the potential molecular mechanism. Methods: Breast Cancer patient-derived organoid (PDO) model was established from the patient who have multiple drug resistance, multiple visceral and contralateral breast metastases. The organoid morphologies was tested by hematoxylin-eosin (HE) staining and immunohistochemistry (IHC). Then, pha

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Guda, Maheedhara R., Andrew J. Tsung, Swapna Asuthkar, and Kiran Velpula. "Abstract 1523: Discovery and Validation of a novel small molecule metabolic inhibitor targeting glioblastoma growth." Cancer Research 85, no. 8_Supplement_1 (2025): 1523. https://doi.org/10.1158/1538-7445.am2025-1523.

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Abstract Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis and limited treatment options. Pyruvate dehydrogenase kinase 1 (PDK1) plays a critical role in the metabolic reprogramming of GBM cells, making it an attractive therapeutic target. In this study, we investigated the efficacy of a novel PDK1 inhibitor, in inhibiting GBM progression. Using U87 glioblastoma cells, we demonstrated that the UIC novel inhibitor significantly reduced cell viability, induced G2/M cell cycle arrest, inhibited glycolysis, and promoted oxidative phosphorylation. In vitro assays revealed that the

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Ye, Genyi, Yuhao Zhao, Junfeng Zhu та ін. "Synergistic Effect of Polydatin and Polygonatum sibiricum Polysaccharides in Combating Atherosclerosis via Suppressing TLR4-Mediated NF-κB Activation in ApoE-Deficient Mice". Evidence-Based Complementary and Alternative Medicine 2022 (7 липня 2022): 1–11. http://dx.doi.org/10.1155/2022/3885153.

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Objective. Atherosclerosis is a chronic inflammatory disease, which is closely related to hyperlipidemia, inflammatory responses, and oxidative stress. As natural products, polydatin (PD) and Polygonatum sibiricum polysaccharides (PSP) have remarkable pharmacological effects in anti-inflammatory, antioxidant stress, and lipid regulation. In this study, we sought to investigate whether the combination of polydatin and P. sibiricum polysaccharides play an anti-atherosclerotic role in alleviating inflammatory responses by inhibiting the toll-like receptor4 (TLR4)/myeloid differentiation factor88(

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Jović, Marko, Ivan Nikolić, Vera Todorović, Aleksandar Petrović, Vladimir Petrović, and Tijana Denčić. "D2-40 Immunoreactivity of Lymphatic Vessels Endothelium and Representation of Lymphatic Vessels in the Liver of Human Fetuses of Different Gestational Age." Acta Facultatis Medicae Naissensis 34, no. 1 (2017): 23–33. http://dx.doi.org/10.1515/afmnai-2017-0003.

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Summary In the reference literature, there are a few studies on the development of the lymphatic system in the liver, especially human. This study aims to establish the presence, time of appearance, distribution and representation of expression D2-40 molecule – a marker of lymph vessels endothelial cells during the fetal period of the human liver development. The livers obtained from 20 human fetuses (10 male and 12 female), aged 12-37 gestational weeks, constituted our study material. Paraffin sections, 4 µm thick, were stained with hematoxylin and eosin for histological analysis, and with LS

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Matkowski, R., I. Gisterek, E. Suder, et al. "Correlation between vascular endothelial growth factor and c-met expressions in breast carcinoma." Journal of Clinical Oncology 24, no. 18_suppl (2006): 10621. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.10621.

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10621 Background: Vascular endothelial growth factor (VEGF) is a specific mitogen and survival factor for endothelial cells and a key promoter of angiogenesis. This cytokine selectively induces cells proliferation and migration, increases permeability of microvessels and activates proteolitic enzymes involved in tumor invasiveness. C-met is tyrosine kinase receptor; its activation can increase tumorigenicity, induce cell motility and enhance invasiveness and metastasis. This protein can increase production of protease and urokinase which are associated with membrane degradation crucial for met

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Wang, Ruinan, Lichengcheng Ren, Yue Wang, et al. "Multi-Protective Effects of Petunidin-3-O-(trans-p-coumaroylrutinoside)-5-O-glucoside on D-Gal-Induced Aging Mice." International Journal of Molecular Sciences 25, no. 20 (2024): 11014. http://dx.doi.org/10.3390/ijms252011014.

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Petunidin-3-O-(trans-p-coumaroylrutinoside)-5-O-glucoside (PtCG), the primary anthocyanin ingredient in Lycium ruthenicum Murr., possesses a range of biological activities, including antioxidative properties and melanin inhibition. This study aimed to investigate the protective effect of PtCG on D-galactose (D-gal)-induced aging in female mice and elucidate the underlying molecular pathways. Behavioral experiments, including the MWW and Y-maze tests, revealed that PtCG significantly ameliorated cognitive decline and enhanced learning and memory abilities in aging mice. Regarding biochemical in

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Heintz, Annabell, Sebastian Sold, Felix Wühler, et al. "Design of a Multimodal Imaging System and Its First Application to Distinguish Grey and White Matter of Brain Tissue. A Proof-of-Concept-Study." Applied Sciences 11, no. 11 (2021): 4777. http://dx.doi.org/10.3390/app11114777.

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Multimodal imaging gains increasing popularity for biomedical applications. This article presents the design of a novel multimodal imaging system. The centerpiece is a light microscope operating in the incident and transmitted light mode. Additionally, Raman spectroscopy and VIS/NIR reflectance spectroscopy are adapted. The proof-of-concept is realized to distinguish between grey matter (GM) and white matter (WM) of normal mouse brain tissue. Besides Raman and VIS/NIR spectroscopy, the following optical microscopy techniques are applied in the incident light mode: brightfield, darkfield, and p

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Huang, Wanqiu, Zheng Liu, Ruibao Chen, Tao Wang, Ruzhu Lan, and Jihong Liu. "Peripheral Primitive Neuroectodermal Tumor (pPNET) of the Penis: A Case Report and Literature Review." International Surgery 100, no. 9-10 (2015): 1340–45. http://dx.doi.org/10.9738/intsurg-d-15-00010.1.

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Primitive neuroectodermal tumors are derived from primitive neuroectodermal cells and belong to a highly malignant subgroup of round-cell tumors. Peripheral primitive neuroectodermal tumors of the penis are an extremely rare malignant form among penile neoplasms. These tumors are often difficult to diagnose due to atypical symptoms. Here, we report a case of a 24-year-old patient in China with a neoplasm localized at the base of his penis. The initial symptom was dysuria without any inducement. The results of blood and urine examinations indicated no abnormalities. The imaging examination resu

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Chen, Yi-Je, Girija Raman, Silke Bodendiek, Martha E. O'Donnell, and Heike Wulff. "The KCa3.1 Blocker TRAM-34 Reduces Infarction and Neurological Deficit in a Rat Model of Ischemia/Reperfusion Stroke." Journal of Cerebral Blood Flow & Metabolism 31, no. 12 (2011): 2363–74. http://dx.doi.org/10.1038/jcbfm.2011.101.

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Microglia and brain infiltrating macrophages significantly contribute to the secondary inflammatory damage in the wake of ischemic stroke. Here, we investigated whether inhibition of KCa3.1 (IKCa1/KCNN4), a calcium-activated K+ channel that is involved in microglia and macrophage activation and expression of which increases on microglia in the infarcted area, has beneficial effects in a rat model of ischemic stroke. Using an HPLC/MS assay, we first confirmed that our small molecule KCa3.1 blocker TRAM-34 effectively penetrates into the brain and achieves micromolar plasma and brain concentrati

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