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Journal articles on the topic 'Eosinophilic otitis media'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ivanny, Putri Sari, Effy Huriyati, and Yan Edward. "Eosinofilik Otitis Media." Human Care Journal 5, no. 2 (2020): 498. http://dx.doi.org/10.32883/hcj.v5i2.715.

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<div class="WordSection1"><p class="Body"><strong>Abstrak</strong><strong></strong></p><p><strong>Pendahuluan: </strong>Eosinofilik otitis media (EOM) merupakan otitis media yang sulit disembuhkan dengan karakteristik adanya cairan efusi berwarna kuning pada telinga tengah dengan viskositas tinggi yang mengandung akumulasi eosinofil yang luas. Onset EOM terjadi pada dekade kelima dengan perbandingan prevalensi eosinofilik otitis media pada wanita dan pria, yaitu sebesar 2 : 1. Pasien dengan EOM akan menunjukkan penurunan pendengaran y

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2

Kavanagh, F. G., W. Hasan, D. A. Smyth, and J. E. Fenton. "Polyps, grommets and eosinophilic granulomatosis with polyangiitis." Journal of Laryngology & Otology 132, no. 3 (2018): 236–39. http://dx.doi.org/10.1017/s0022215117002444.

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AbstractObjective:To explore the link between nasal polyposis, refractory otitis media with effusion and eosinophilic granulomatosis with polyangiitis.Methods:A retrospective observational study was carried out of patients diagnosed with refractory otitis media with effusion necessitating grommet insertion and who had nasal polyps. Patients were evaluated to determine if they fulfilled the diagnostic criteria of eosinophilic granulomatosis with polyangiitis.Results:Sixteen patients (10 males and 6 females) were identified. The mean age of grommet insertion was 45.4 years. The mean number of gr

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3

Childers, Adrienne L., Judah Gruen, Sadia Sayeed, Celeste N. Powers, and Daniel H. Coelho. "Eosinophilic Otitis Media." Otology & Neurotology 35, no. 6 (2014): e206-e207. http://dx.doi.org/10.1097/mao.0000000000000369.

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4

Lara-Sánchez, Hugo, and Luis A. Vallejo. "Eosinophilic Otitis Media." New England Journal of Medicine 376, no. 7 (2017): e10. http://dx.doi.org/10.1056/nejmicm1510852.

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5

Jeong, Yeonsu, Gina Na, Jong-Gyun Ha, Dachan Kim, Junyup Kim, and Seonghoon Bae. "Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels." Diagnostics 13, no. 23 (2023): 3598. http://dx.doi.org/10.3390/diagnostics13233598.

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Eosinophilic otitis media (EOM) is a rare middle ear disease with unfavorable outcomes. Under the current diagnostic criteria of EOM, it is challenging to suspect EOM before tympanostomy. Therefore, this study attempted to use blood eosinophil levels for the differential diagnosis of EOM from other conditions. Three disease groups with features of recurrent otorrhea were categorized, which included the following: EOM (n = 9), granulomatosis with polyangiitis (GPA, n = 12), and primary ciliary dyskinesia (PCD, n = 6). Clinical and radiological characteristics were analyzed in the three groups.

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6

Turkmen, Mehmet Turgay, and Recep Yagiz. "A Case of Intractable Otitis Media: Eosinophilic Otitis Media." Balkan Medical Journal 31, no. 3 (2014): 268–69. http://dx.doi.org/10.5152/balkanmedj.2014.13272.

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7

Matsubara, Atsushi, Hisanori Nishizawa, and Jyunko Takahata. "Eosinophilic otitis media and periostin." Journal of Japan Society of Immunology & Allergology in Otolaryngology 34, no. 1 (2016): 19–24. http://dx.doi.org/10.5648/jjiao.34.19.

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8

Matsubara, Atsushi, Naomi Kudo, Tomoya Miura, and Ryutaro Hara. "Treatment for eosinophilic otitis media." Journal of Japan Society of Immunology & Allergology in Otolaryngology 35, no. 3 (2017): 257–60. http://dx.doi.org/10.5648/jjiao.35.257.

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9

Kawano, Toshiro, Junichi Ishitoya, and Mamoru Tsukuda. "Sinusitis with Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 100, no. 9 (2007): 715–24. http://dx.doi.org/10.5631/jibirin.100.715.

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10

Fukuda, Atsushi, Shinya Morita, Yuji Nakamaru, Kimiko Hoshino, Keishi Fujiwara, and Akihiro Homma. "Differentiation Between Eosinophilic Otitis Media and Otitis Media Associated With Eosinophilic Granulomatosis With Polyangiitis." Otology & Neurotology 40, no. 8 (2019): e796-e802. http://dx.doi.org/10.1097/mao.0000000000002295.

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11

Tanaka, Yasuhiro. "Eosinophilic otitis media and eosinophilic granulomatosis with polyangiitis." Journal of Japan Society of Immunology & Allergology in Otolaryngology 36, no. 4 (2018): 271–74. http://dx.doi.org/10.5648/jjiao.36.271.

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12

Wang, Zijing, Lin Han, and Lisheng Yu. "Effects of surgery and topical medication on eosinophilic granulomatosis with polyangiitis with otitis media and sinusitis: a case report." Journal of International Medical Research 48, no. 4 (2020): 030006052092004. http://dx.doi.org/10.1177/0300060520920049.

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Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg–Strauss syndrome, is eosinophil-rich, necrotizing granulomatous inflammation often involving the respiratory tract. Furthermore, EGPA is necrotizing vasculitis that predominantly affects small to medium vessels and is associated with asthma and eosinophilia. Most patients with EGPA have sinusitis and some complain of hearing loss and refractory otitis media with effusion. Systemic use of immunosuppressants and glucocorticoids is currently recommended, despite the inevitable associated side effects. However, systemic trea

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13

Matsubara, Atsushi. "The Diagnosis of Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 107, no. 8 (2014): 600–601. http://dx.doi.org/10.5631/jibirin.107.600.

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14

Kawano, Toshiro, Junichi Ishitoya, Ryo Endo, and Mamoru Tsukuda. "Conservative Treatment of Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 100, no. 12 (2007): 965–71. http://dx.doi.org/10.5631/jibirin.100.965.

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15

Kishibe, Kan, Toshihiro Nagato, Takurou Tosho, Tatsuya Hayashi, Satoshi Nonaka, and Yasuaki Harabuchi. "Case Reports of Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 97, no. 6 (2004): 499–506. http://dx.doi.org/10.5631/jibirin.97.499.

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16

Seo, Yukako, Manabu Nonaka, and Ruby Pawankar. "Eosinophilic otitis media and comorbid asthma." Current Opinion in Allergy and Clinical Immunology 20, no. 1 (2020): 9–13. http://dx.doi.org/10.1097/aci.0000000000000589.

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17

Nakagawa, Takashi, Shizuo Komune, and Atsushi Matsubara. "Clinical Findings of Eosinophilic Otitis Media." Otolaryngology–Head and Neck Surgery 131, no. 2 (2004): P288. http://dx.doi.org/10.1016/j.otohns.2004.06.622.

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18

Takahashi, Masahiro, Aiko Oka, Shin Kariya, et al. "IgG4 Expression in Patients with Eosinophilic Otitis Media." ORL 83, no. 3 (2021): 167–71. http://dx.doi.org/10.1159/000512726.

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<b><i>Objective:</i></b> Eosinophilic otitis media (EOM) is an intractable middle ear disease recognized by an eosinophil enriched middle ear effusion and mucosa. Although precise pathogenesis of EOM remains unclear, it is characterized by type 2 inflammation. Since IgG4 is an IgG subclass induced by type 2 cytokines such as IL-4 and IL-13, we sought to characterize and compare local IgG4 expression in patients with and without EOM. <b><i>Methods:</i></b> Twelve patients with bilateral profound hearing loss, 9 of which underwent a cochlear implan

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19

Iino, Yukiko. "Role of IgE in Eosinophilic Otitis Media." Allergology International 59, no. 3 (2010): 233–38. http://dx.doi.org/10.2332/allergolint.10-rai-0223.

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20

De Corso, Eugenio, Claudio Montuori, Stefano Settimi, et al. "Efficacy of Biologics on Refractory Eosinophilic Otitis Media Associated with Bronchial Asthma or Severe Uncontrolled CRSwNP." Journal of Clinical Medicine 11, no. 4 (2022): 926. http://dx.doi.org/10.3390/jcm11040926.

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Eosinophilic otitis media (EOM) is a difficult-to-treat otitis media characterized by eosinophilic accumulation in the middle ear mucosa and effusion. It is resistant to conventional treatments and strongly associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of our study is to evaluate the effectiveness of biologics drugs in the control of EOM. This is a retrospective no-profit real-life observational study, involving patients affected by refractory EOM and in treatment with different biologics for concomitant severe eosinophilic asthma or severe uncontrolled

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21

Matsubara, Atsushi. "Eosinophilic Otitis Media: Basic Research and Clinical Manifestations." Practica Oto-Rhino-Laryngologica 108, no. 10 (2015): 737–44. http://dx.doi.org/10.5631/jibirin.108.737.

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22

Takahashi, Masahiro, Yasuhiro Arai, Naoko Sakuma, et al. "Cochlear Implantation in Patients with Eosinophilic Otitis Media." International Journal of Otolaryngology and Head & Neck Surgery 04, no. 01 (2015): 32–37. http://dx.doi.org/10.4236/ijohns.2015.41006.

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23

Saliba, Issam, Musaed Alzahrani, Xiaoduan Weng, and Alain Bestavros. "Eosinophilic otitis media diagnosis using flow cytometric immunophenotyping." Acta Oto-Laryngologica 138, no. 2 (2017): 110–15. http://dx.doi.org/10.1080/00016489.2017.1385845.

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24

Nagamine, Hisayo, Yukiko Iino, Chie Kojima, Tetsuo Miyazawa, and Takashi Iida. "Clinical characteristics of so called eosinophilic otitis media." Auris Nasus Larynx 29, no. 1 (2002): 19–28. http://dx.doi.org/10.1016/s0385-8146(01)00124-9.

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25

Breslin, Nathaniel K., N. Hadley Heindel, and Rex S. Haberman. "Role of Interleukin 5 Inhibition in the Treatment of Eosinophilic Otitis Media." OTO Open 5, no. 1 (2021): 2473974X2199144. http://dx.doi.org/10.1177/2473974x21991449.

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Objective Eosinophilic otitis media (EOM) is a rare form of middle ear disease characterized by a viscous effusion rich in eosinophils, a resistance to conventional treatments, and an association with bronchial asthma. The relationship between asthma and EOM suggests similarities in pathogenesis and treatment possibilities. Recent biologic therapies, specifically those that target interleukin 5 (IL-5), have demonstrated efficacy in controlling eosinophil-driven asthma, yet their impact on the treatment of pathologically similar diseases remains unmeasured. This study identifies patients who ha

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26

Iino, Y., K. Kakizaki, H. Katano, H. Saigusa, and S. Kanegasaki. "Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media." Clinical Experimental Allergy 35, no. 10 (2005): 1370–76. http://dx.doi.org/10.1111/j.1365-2222.2005.02330.x.

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27

Uchimizu, Hirotaka, Yoshinori Matsuwaki, Masahiko Kato, Nobuyosi Otori, and Hiromi Kojima. "Eosinophil-derived neurotoxin, elastase, and cytokine profile in effusion from eosinophilic otitis media." Allergology International 64 (September 2015): S18—S23. http://dx.doi.org/10.1016/j.alit.2015.03.007.

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28

Sugahara, Kazuma, and Hiroshi Yamashita. "Cochlear Implants for the Patients with Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 112, no. 12 (2019): 786–87. http://dx.doi.org/10.5631/jibirin.112.786.

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29

Tanaka, Yukako, Manabu Nonaka, Yukie Yamamura, Etsuko Tagaya, Ruby Pawankar, and Toshio Yoshihara. "Improvement of Eosinophilic Otitis Media by Optimized Asthma Treatment." Allergy, Asthma & Immunology Research 5, no. 3 (2013): 175. http://dx.doi.org/10.4168/aair.2013.5.3.175.

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30

Iino, Yukiko, Yoshihiko Esu, Hiromi Kanazawa, and Naohiro Yoshida. "Clinical characteristics and diagnostic criteria of eosinophilic otitis media." Journal of Laryngology & Otology 130, S3 (2016): S89—S90. http://dx.doi.org/10.1017/s002221511600356x.

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31

Iino, Yukiko. "Eosinophilic otitis media: A new middle ear disease entity." Current Allergy and Asthma Reports 8, no. 6 (2008): 525–30. http://dx.doi.org/10.1007/s11882-008-0096-5.

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32

Iwasaki, Satoshi, Mitsuyoshi Nagura, and Kunihiro Mizuta. "Cochlear implantation in a patient with eosinophilic otitis media." European Archives of Oto-Rhino-Laryngology 263, no. 4 (2005): 365–69. http://dx.doi.org/10.1007/s00405-005-1006-2.

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33

Kanazawa, Hiromi, Naohiro Yoshida, Hiroki Yamamoto, et al. "Risk factors associated with severity of eosinophilic otitis media." Auris Nasus Larynx 41, no. 6 (2014): 513–17. http://dx.doi.org/10.1016/j.anl.2014.08.003.

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34

Masuda, Maria, Yoshihiko Esu, Yukiko Iino, and Naohiro Yoshida. "Risk factors for bacterial infection in eosinophilic otitis media." Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) 125, no. 12 (2022): 1734–35. http://dx.doi.org/10.3950/jibiinkotokeibu.125.12_1734.

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35

Drijver-Messelink*, Marieke T., Mariette Wagenaar, Jacqueline van der Meij, and Anneke ten Brinke. "Eosinophilic otitis media and eosinophilic asthma: Shared pathophysiology and response to anti-IL5." Journal of Pulmonology and Respiratory Research 3, no. 1 (2019): 009–12. http://dx.doi.org/10.29328/journal.jprr.1001011.

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36

Yoshida, Naohiro. "Intractable otitis media-Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV)." Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) 127, no. 10 (2024): 1095–97. http://dx.doi.org/10.3950/jibiinkotokeibu.127.10_1095.

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37

Yokoyama, Yukiko, Ruby Pawankar, Chika Ozu, Tetsuo Ikezono, Manabu Nonaka, and Toshiaki Yagi. "Mechanisms of eosinophil infiltration in the middle ear of patients with eosinophilic otitis media." World Allergy Organization Journal &NA; (November 2007): S189. http://dx.doi.org/10.1097/01.wox.0000301861.17941.ba.

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38

Aggarwal, Purnima, Uma Debi, and Geetanjli Jindal. "Primary eosinophilic granuloma presenting as bilateral otitis media and mastoiditis." El Mednifico Journal 2, no. 2 (2014): 151. http://dx.doi.org/10.18035/emj.v2i2.96.

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39

Chen, Tiffany, Peter E. Ashman, Dennis I. Bojrab, et al. "Diagnosis and management of eosinophilic otitis media: a systematic review." Acta Oto-Laryngologica 141, no. 6 (2021): 579–87. http://dx.doi.org/10.1080/00016489.2021.1901985.

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40

Hong, Senung No, Hanaro Park, Juyoung Chung, et al. "Audiological and Clinical Finding of Eosinophilic Otitis Media in Korea." Korean Journal of Otorhinolaryngology-Head and Neck Surgery 56, no. 11 (2013): 692. http://dx.doi.org/10.3342/kjorl-hns.2013.56.11.692.

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41

Iwatsuka, Kazuko. "A Patient with Churg-Strauss Syndrome Including Eosinophilic Otitis Media." Practica Oto-Rhino-Laryngologica 98, no. 6 (2005): 447–52. http://dx.doi.org/10.5631/jibirin.98.447.

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42

Kamei, Masayo, Yuka Ookawa, Ken Ishijima, Hiroaki Sato, Hitoshi Kobayashi, and Akira Kurose. "A Case of Eosinophilic Otitis Media Aggravated by Lung Cancer." Practica Oto-Rhino-Laryngologica 98, no. 8 (2005): 611–16. http://dx.doi.org/10.5631/jibirin.98.611.

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43

Kim, Yee-Hyuk, Jae-Jin Ko, Ho-Jin Son, and Seung-Heon Shin. "A Case of Allergic Fungal Sinusitis with Eosinophilic Otitis Media." Journal of Clinical Otolaryngology Head and Neck Surgery 23, no. 2 (2012): 279–82. http://dx.doi.org/10.35420/jcohns.2012.23.2.279.

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44

Chung, Won Jung, Jeong Hyun Lee, Hyun Kyung Lim, Tae Hyun Yoon, Kyung Ja Cho, and Jung Hwan Baek. "Eosinophilic Otitis Media: CT and MRI Findings and Literature Review." Korean Journal of Radiology 13, no. 3 (2012): 363. http://dx.doi.org/10.3348/kjr.2012.13.3.363.

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45

Iino, Yukiko, Mariko Hara, Masayo Hasegawa, et al. "Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media." Otology & Neurotology 33, no. 7 (2012): 1218–24. http://dx.doi.org/10.1097/mao.0b013e318263d5b8.

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46

Willits, Erin, Erin O'Brien, Brian Neff, and Joseph H. Butterfield. "The First US Cohort of Eosinophilic Otitis Media: Clinical Characteristics." Journal of Allergy and Clinical Immunology 139, no. 2 (2017): AB154. http://dx.doi.org/10.1016/j.jaci.2016.12.508.

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47

Kurihara, Momoko, Katsunori Masaki, Emiko Matsuyama, et al. "How Can Dupilumab Cause Eosinophilic Pneumonia?" Biomolecules 12, no. 12 (2022): 1743. http://dx.doi.org/10.3390/biom12121743.

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Reports of eosinophilic pneumonia (EP) as a side effect of dupilumab administration are limited in previous studies. Herein, we report two cases in which EP developed subsequent to the administration of dupilumab for eosinophilic chronic rhinosinusitis (ECRS). Case 1: A 55-year-old woman presented with ECRS, eosinophilic otitis media, and bronchial asthma, and was treated with dupilumab for ECRS. Five weeks later, fever and dyspnea developed, and infiltration shadows were observed in her lungs. The peripheral blood eosinophil count (PBEC) was 3848/μL (26%), bronchoalveolar lavage fluid showed

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48

Nonaka, Manabu, Yukako Seo, Emiri Sato, Masayoshi Mukai, and Kanako Goto. "Characteristics of Eosinophilic Otitis Media and Eosinophilic Chronic Rhinosinusitis, and Their Relationships with Comorbid Asthma." Practica Oto-Rhino-Laryngologica 113, no. 7 (2020): 405–11. http://dx.doi.org/10.5631/jibirin.113.405.

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49

Okude, Azusa, Etsuko Tagaya, Mitsuko Kondo, Manabu Nonaka, and Jun Tamaoki. "A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab." Case Reports in Pulmonology 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/340525.

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A 51-year-old woman had been receiving medical treatment for asthma since she was 21 years old. However, her asthma was poorly controlled despite treatment involving combination inhalation of high-dose corticosteroid and long-actingβ2-aderenergic agonist (LABA) and regularly taking oral steroids. Hearing loss and otorrhea appeared at the age of 44, and she was given a diagnosis of eosinophilic otitis media (EOM) and received medical treatment. In 2007, symptoms of asthma and otitis media deteriorated. In December 2009, omalizumab therapy was started for refractory asthma. After 2 months of oma

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50

Oshima, Hidetoshi, Tetsuaki Kawase, and Toshimitsu Kobayashi. "Omalizumab Effect on Eosinophilic Otitis Media and Sinusitis: A Case Report." Practica Oto-Rhino-Laryngologica 104, no. 5 (2011): 319–23. http://dx.doi.org/10.5631/jibirin.104.319.

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