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Dissertations / Theses on the topic 'Ependymal stem progenitor cells'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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1

MARCUZZO, STEFANIA. "New insights in the understanding of motor neuron disease by longitudinal brain and muscle MRI analysis and characterization of spinal cord-derived stem cells in G93-SOD1 mouse model of ALS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43854.

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Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative disorder caused by the degeneration of motor neurons in the CNS, which results in complete paralysis of skeletal muscles. To establish the timeframe of motor neuron degeneration in relation to muscle atrophy in motor neuron disease, we have used MRI to monitor changes throughout disease in brain and skeletal muscle of G93A-SOD1 mice, a purported model of ALS. Longitudinal MRI examination of the same animals indicated that muscle volume in the G93A-SOD1 mice was significantly reduced from as early as week 8 of life,
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2

Noisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes
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3

Marshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.
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4

Greenhowe, Jennifer. "Stem and progenitor cells in wound healing." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:87a9a7a1-b595-458a-913f-64497174f988.

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As more patients with large body surface area burns are surviving and requiring reconstructive surgery, there is a necessity for advances in the provision of bioengineered alternatives to autologous skin cover. The aims of this Thesis are to identify feasible source tissues of Endothelial Colony Forming Cells and Mesenchymal Stem/Stromal Cells for microvascular network formation in vitro with three-dimensional dermal substitute scaffolds. The working hypothesis is that pre-vascularised dermal scaffolds will result in better quality scarring when used with split thickness skin grafts. Human umb
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5

Pearce, Daniel. "Intracellular analysis of stem and progenitor cells." Thesis, Kingston University, 2001. http://eprints.kingston.ac.uk/20685/.

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A population of rare pluripotential stem cells with extensive proliferative and self-renewal capabilities sustains haemopoiesis throughout life. Such cells, capable of differentiating into any haemopoietic lineage are required for gene therapy, ex-vivo expansion and stem cell transplantation strategies. It is currently not possible to positively identify these cells; their presence can only be retrospectively assessed through elaborate, time consuming culture techniques and animal repopulating studies. Stem cells can be isolated through negative selection, a complex and very expensive procedur
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6

Chavez, Garcia Edison. "Phosphoinositides regulation and function in the ciliary compartment of Neural stem cells and Ependymal cells." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/221625.

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This thesis describes the work that I have carried out in the Laboratory of Neurophysiolgy at the Université Libre de Bruxelles, under the supervision of Prof. Serge Schiffmann, in collaboration with Prof. Stéphane Schurmans of Université of Liège.The work is divided in two distinct but related projects and the results section is thus divided into two main chapters. The results described are presented in the form of two manuscripts, the first chapter is named “Ciliary phosphoinositides regulation by INPP5E controls Shh signaling by allowing trafficking of Gpr161 in neural stem cells primar
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7

Neilson, Kirstie Jane. "Differentiation of mouse embryonic stem cells into endothelial progenitor cells." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500200.

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8

Addicks, Gregory Charles. "Epigenetic Regulation of Muscle Stem and Progenitor Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37112.

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Epigenetic mechanisms are of fundamental importance for resolving and maintaining cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration and maintenance. Important roles for the trithorax H3K4 histone methyltransferase (HMT) MLL1 have been established for early embryogenesis, and for hematopoietic and neural identity. Here, using a conditional Mll1 knockout
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9

Schütte, Judith. "Analysis of regulatory networks in blood stem/progenitor cells." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648631.

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10

Ma, Kwai-yee Stephanie. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557534.

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11

Liu, Yi. "LATEXIN’S ROLE IN REGULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/11.

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Previous studies in our lab identified a novel gene, latexin (Lxn), that regulates murine hematopoietic stem cells through balancing apoptosis, self-renewal and proliferation. In these dissertation studies, I performed a series of experiments to examine the function of Lxn using a Lxn conventional knockout mouse, and characterize Lxn’s role in the presence of hematopoietic stresses such as ionizing radiation, cytokines induced-mobilization, and hematopoietic malignancy. The first series of experiments was designed to determine the role of Lxn in hematopoiesis under homeostatic conditions. I fo
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12

Prater, Michael David. "Progenitor and stem cell potential of mammary myoepithelial cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648364.

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13

Gu, P. "Isolation and characterization of porcine retinal stem/progenitor cells." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437871.

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14

Giraddi, Rajashekharagouda. "Cell cycle kinetics of mammary stem and progenitor cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607789.

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15

Ulyanchanka, Sviatlana. "Identification of stem/progenitor cells in the postnatal thymus." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/11736.

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The thymus is the principal site of T-cell development and maturation. Failure to develop a functional thymus leads to severe immunodeficiency, while partially incorrect function of the organ can lead to a variety of autoimmune diseases as well as higher risk for infections and cancer. The thymus is organized into cortical and medullary regions, which are functionally distinct. The diverse array of thymic epithelial cells (TEC) are the key components of the thymic stroma, both the cortical and medullary TEC subsets are responsible for the establishment of a self-tolerant and self-restricted T-
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16

Hemmati, Houman David Rothenberg Ellen V. "Neural stem and progenitor cells in cancer and development /." Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-05232006-140457.

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17

Robins, Sarah. "Neural stem/progenitor cells in the adult mouse hypothalamus." Thesis, University of Sheffield, 2009. http://etheses.whiterose.ac.uk/111/.

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Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem cells resides in the hypothalamus, more specifically in the ependymal lining of the third ventricle. In this thesis, I tested the hypothesis that stem cells exist in defined regions of the adult mouse hypothalamus. My work confirms the presence of stem/progenitor cells in the adult mouse hypothalamus. An
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18

Ma, Kwai-yee Stephanie, and 馬桂宜. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557534.

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Li Ka Shing Prizes for best PhD theses in the Faculties of Dentistry, Engineering, Medicine and Science, 2006-2007<br>published_or_final_version<br>abstract<br>Pathology<br>Doctoral<br>Doctor of Philosophy
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19

Bird, Thomas Graham. "Liver regeneration by hepatic progenitor cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5634.

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The liver is the largest solid organ in the body and is frequently the site of injury. During disease, liver injury is usually compensated for by exceptionally efficient regeneration which occurs both from differentiated epithelia and also from an undifferentiated cell population with stem cell like qualities known as hepatic progenitor cells (HPCs). HPCs are particularly active during massive or chronic liver injury and therefore are an attractive target for much needed novel therapies to enhance regeneration in patients for whom the only current effective therapy is liver transplantation. St
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20

Jin, Xin. "Towards differentiation of mouse embryonic stem cells to thymic epithelial progenitor cells." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/12227.

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The thymus is the major site for T-cell generation and thus is important for the adaptive immune system. Development of a properly selected, functional T-cell repertoire relies on interactions between developing T cells and a series of functionally distinct thymic stroma cell types including the cortical and medullary thymic epithelial cells (TECs). The thymus is one of the first organs to degenerate in normal healthy ageing. Related to this, there is strong interest in developing protocols for improving thymus function in patients by cell replacement or regenerative therapies. Thymic epitheli
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21

Malandraki-Miller, Sophia. "Enhancing progenitor cells for cell therapy after myocardial infarction." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:205043f4-e3e0-4947-9afc-b43f1543e0bd.

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Based on data from the World Healthcare Organisation, cardiovascular diseases are the primary cause of disease-related death globally, with myocardial infarction (MI) being the most prevalent. If not treated effectively, MI can progress to heart failure (HF). With 70 million prescriptions for HF in 2014 and 515 people in the UK being hospitalised daily with MI, the British Heart Foundation calls for novel robust treatments. Even though cardiac stem cell (CSC) therapy for MI has been under investigation for more than a decade, there still has not been a consensus over the identity of the adult
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22

Guzmán, Ramírez Natalia. "Characterization of stem/progenitor cells from human prostate cancer tissue." [S.l.] : [s.n.], 2009. http://www.zb.unibe.ch/download/eldiss/09guzmanramirez_n.pdf.

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23

Markeson, D. B. "Vascularised scaffolds for cutaneous wound reconstruction using stem/progenitor cells." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469485/.

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The synthetic replacement of full thickness skin is suboptimal both aesthetically and functionally. One approach to improve existing dermal substitutes is to pre-vascularise them to facilitate incorporation. In so doing, the aim is to improve the trajectory of wound healing. More expeditious maturation has been suggested to improve outcomes. Endothelial colony forming cells (ECFCs), specialised progenitor cells required for vasculogenesis, were isolated from cord (CBECFC) and peripheral (PBECFC) blood. Mesenchymal stromal cells were separated from adipose tissue (AdMSCs). Using a proprietary d
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24

Lu, Wei-Yu. "Defining the liver repopulating capacities of hepatic progenitor cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17875.

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The liver has the ability to regenerate rapidly during acute liver injury by activating mature hepatocytes to divide and restore the damaged liver mass. In contrast, the liver relies on hepatic progenitor cells (HPCs) which have the ability to differentiate into both hepatocytes and biliary cells for regeneration during chronic liver injuries. Whole organ transplant is the most effective treatment for end stage liver diseases. However, there is a constant shortage of donor organs causing the death of many patients while waiting for suitable donor organs. HPC transplant is a potential alternati
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25

Guthrie, Steven Mitchell. "Hemangioblasts from hematopoietic stem cells to endothelial progenitor cells and their effector molecules /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010068.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 95 pages. Includes Vita. Includes bibliographical references.
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26

Dause, Tyler. "Investigating Neural Stem and Progenitor Cell Intracrine Signaling." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555618643450352.

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27

Chong, Tsz-yat Ian, and 莊子逸. "Inducing the progressive differentiation of hESCs into pancreatic progenitor cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196433.

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Diabetes is a chronic disorder of the pancreas, where a decline in the insulin-producing β-cell population disrupts metabolic homeostasis. Pancreatic transplantation has shown to be effective in circumventing the problem of β-cell insufficiency. However, availability of donor islets remains an obstacle. Although progressive differentiation of embryonic stem cells (ESCs) to pancreatic β-cells is a solution, current protocols are wrought with inefficiencies. It is obvious that to realize ESC differentiation for therapy many steps need to be optimized, and this study describes improvement of Pdx1
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28

Wallenquist, Ulrika. "Neural Stem and Progenitor Cells as a Tool for Tissue Regeneration." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110095.

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Neural stem and progenitor cells (NSPC) can differentiate to neurons and glial cells. NSPC are easily propagated in vitro and are therefore an attractive tool for tissue regeneration. Traumatic brain injury (TBI) is a common cause for death and disabilities. A fundamental problem following TBI is tissue loss. Animal studies aiming at cell replacement have encountered difficulties in achieving sufficient graft survival and differentiation. To improve outcome of grafted cells after experimental TBI (controlled cortical impact, CCI) in mice, we compared two transplantation settings. NSPC were tra
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29

Hertwig, Falk [Verfasser]. "Development of brain tumors from neural stem, progenitor cells / Falk Hertwig." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1027308503/34.

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30

Redpath, Andia Nicole. "Pharmacological mobilisation of murine mesenchymal stem/progenitor cells : identifying potential mechanisms." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/50292.

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Mesenchymal stem/progenitor cells (MSPCs) isolated from adult tissues and expanded ex vivo exhibit multipotency, immunomodulatory and regenerative properties; and thus are currently being assessed in many clinical trials. In contrast, this study focuses on understanding native MSPC properties to ultimately exploit their regenerative potential using pharmacological methods. It was previously demonstrated that pretreatment of mice with VEGF over 4 days primed MSPCs for mobilisation from the bone marrow (BM) to the peripheral blood in response to the CXCR4 antagonist, AMD3100. In this study, poss
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Mooney, Ciarán James. "Expression of growth factor receptors by haematopoietic stem and progenitor cells." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7332/.

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The mechanisms that govern the lineage commitment of haematopoietic stem and progenitor cells (HSPCs) have been a topic of debate since the 1960s. Two models of lineage commitment have been described; a permissive model, in which haematopoietic growth factors (HGFs) stimulate proliferation and survival of distinct HSPC subpopulations to permit stochastic lineage-specification, and a deterministic model, which proposes that HGFs instruct HSPCs to differentiate towards a specific cell lineage. To provide further insight into whether HGFs provide instructive cues or act in a selective manner, thi
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Dam, Noémie Thi Nhu Quynh. "Allogeneic cardiac stem/progenitor cells and innate immune and humoral responses." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC251.

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Dans une société vieillissante, les maladies cardiovasculaires comme l’infarctus du myocarde représentent un challenge pour le système de santé. Les cellules souches, qui ont le potentiel de régénérer/réparer les organes tout au long de notre vie, constituent un traitement thérapeutique prometteur. Les stratégies qui ont utilisé des cellules autologues se sont heurtées à des limites que n’ont pas les cellules allogéniques mais leur immunogénicité peut constituer un obstacle à leur utilisation. Notre objectif a été d’étudier l’interaction des cellules souches/progéniteurs cardiaques humaines (h
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Stewart, Iain. "Characterisation of adult neural stem/progenitor cells in the murine hypothalamus." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/5415/.

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Recent evidence has shown that adult neurogenesis is sustained in the hypothalamus, a region of the ventral diencephalon that is the central regulator of homeostasis. While studies support a role for adult neurogenesis in energy balance, as yet, the identity of the neural stem/progenitor cell niche remains contested. Tanycyte cells, a unique population to the hypothalamus, present a possible candidate due to their diverse roles, radial-glial like morphology and position adjacent to the 3rd ventricle. Here, I provide in-vivo, in-vitro and ex-vivo data that together support alpha-tanycytes as a
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34

PIBIRI, VALERIA. "Immunohistochemical markers of stem/progenitor cells in the developing human cerebellum." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255995.

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The aim of this study was to identify the stem/progenitor cell markers, by immunohistochemistry, in order to highlight the cortical neurogenesis niches during the different gestational ages. To this end, the following stem/progenitor cell markers have been utilized: Sox2, Pax6, Pax2, WT1, Nestin, Vimentin and Calretinin. The expression of these markers have been compared with the expression of those markers of mature neurons and glial markers including Neurofilament (NF), neuron specific enolase (NSE), Synaptophysin (Syn), Glial fibrillary acid protein (GFAP) and S100β. Evaluating both stem/
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LAI, FEDERICA. "Immunohystochemical markers of stem/progenitor cells in the fetal human liver." Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/260751.

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The documentation and the characterization of human stem/progenitor cells of the liver is interesting subject of the current scientific literature. Stem/progenitor cells are a heterogenus population characterized by a range of morphological and immunohistochemical features from bile duct cells to hepatocytes. They are typically characterized by the self-renewal ability able to differentiate into diverse lineage after injury or damage.. This study evaluated the immunohistochemical expression of different type of cytokeratins (CK7, CK14 and CK19) at different gestational ages in order to identif
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36

Sone, Masakatsu. "Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells." Kyoto University, 2004. http://hdl.handle.net/2433/147492.

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37

Gotoh, Shimpei. "Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells." Kyoto University, 2015. http://hdl.handle.net/2433/195967.

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Final publication is available at http://dx.doi.org/10.1016/j.stemcr.2014.07.005. Shimpei Gotoh, Isao Ito, Tadao Nagasaki, Yuki Yamamoto, Satoshi Konishi, Yohei Korogi, Hisako Matsumoto, Shigeo Muro, Toyohiro Hirai, Michinori Funato, Shin-Ichi Mae, Taro Toyoda, Aiko Sato-Otsubo, Seishi Ogawa, Kenji Osafune, Michiaki Mishima, Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells, Stem Cell Reports, Volume 3, Issue 3, 9 September 2014, Pages 394-403, ISSN 2213-6711.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第18681号<br>医博第395
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Zhang, Yingying, and 张莹莹. "Functional ion channels in human bone marrow-derived mesenchymal stem cells and human cardiac c-kit+ progenitor cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50567032.

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Baba, Shiro. "Flk1[+] cardiac stem/progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model." Kyoto University, 2008. http://hdl.handle.net/2433/135803.

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Gomes, Cátia Sofia Vicente. "Cues for cancer stem cells origin." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/12439.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Neural stem/progenitor cells (NSPC) can differentiate into neurons and glial cells in the central nervous system. Interestingly, NSPC biology is being applied to the study of human brain tumours, since these cells share some common features with glioma cells. However, it is not known the developmental stage with more similarities to glioma cells, or the most susceptible to malignant transformation. We aimed to identify the stage(s) in the NSPC differentiation process towards astrocytes where cells acquire phen
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Ewels, Philip Andrew. "Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245861.

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The eukaryotic cell nucleus is a highly organised organelle, with distinct specialised sub- compartments responsible for specific nuclear functions. Within the context of this functional framework, the genome is organised, allowing contact between specific genomic regions and sub-compartments. Previous work has shown that genes in both cis and trans can make specific contacts with each other. I hypothesise that such a preferred juxtaposition may impact the propensity for specific cancerinitiating chromosomal translocations to occur. In this thesis, I describe how I have extended and developed
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Xiang, Lina, and 向丽娜. "Functional characterization of human endometrial stem/progenitor cells in vitro and in vivo." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/206991.

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Human endometrium undergoes cyclic tissue breakdown and regeneration throughout a woman of reproductive life. It has been speculated that there is a subpopulation of stem/progenitor cells residing in the endometrium responsible to its remarkable capability. One key feature that distinguishes the adult stem cells is their quiescent state within the stem cell niche. Based on this unique stem cell property, slow-cycled cells from human endometrial tissues were examined and characterized. The first aim of this study was to examine label retaining cells (LRCs) in long-term engrafted human endometri
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Masek, Lisa Christina. "The study of adhesive interactions between haemopoietic progenitor cells and bone marrow sinusoidal endothelial cells." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242854.

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Kollek, Matthias [Verfasser], and Miriam [Akademischer Betreuer] Erlacher. "Improvement of hematopoietic stem cell transplantations by transient apoptosis inhibition in donor stem and progenitor cells." Freiburg : Universität, 2016. http://d-nb.info/1136263462/34.

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Sabapathy, S. "Optimisation of methods for the differentiation of human embryonic stem cells into retinal progenitor cells." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1459964/.

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Many ocular diseases result in visual impairment often leading to blindness with disease progression, one such example is Retinitis pigmentosa (RP). The underlying cause for blindness is often due to the degeneration of photoreceptors and supporting cells in the retina. Photoreceptors are responsible for the conversion of light signals into electrical impulses which are processed by the brain to form a visual image. Unlike other cells, photoreceptors cannot be regenerated by the body. For this reason current treatment for many ocular diseases aims to preserve what little vision patients hold.
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Brown, James Augustus. "Comparison of bone marrow mesenchymal stem cells and tendon progenitor cells cultured on collagen surfaces." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/77011.

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Tendon injuries are a significant cause of morbidity in performance horses with superficial digital flexor tendon injury reported to represent up to 43% of overall Thoroughbred racehorse injuries. Natural repair is slow and results in inferior structural organization and biomechanical properties and, therefore, reinjury is common. The inability of tendon to regenerate after injury, or to heal with mechanical properties comparable to the original tissue, is likely attributable to low vascularity and cellularity of the tissue, low number of resident progenitor cells, and healing under weight-bea
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Selander, Lars. "In vivo and in vitro approaches to induce beta cells from stem and progenitor cells." Doctoral thesis, Umeå : Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25813.

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Xin, Xing. "Effects of polychlorinated biphenyls (PCBs) on telomere maintenance in hematopoietic stem cells and progenitor cells." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2026.

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Polychlorinated biphenyls (PCBs) are synthetic persistent organic compounds that are known to be carcinogenic to humans. Changes in telomerase activity and telomere length are hallmarks of aging and carcinogenesis. Retention of telomerase activity and long telomeres are key characteristics of stem cells and progenitor cells. I hypothesize that PCBs modulate telomerase activity and telomeres of hematopoietic stem cells and progenitor cells via interference of gene regulation and potentially disrupt c
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Tabayoyong, William Borj. "Engraftment of embryonic stem cell-derived hematopoietic progenitor cells is regulated by natural killer cells." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1089.

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Embryonic stem (ES) cells possess the remarkable ability to form cells and tissues from all three germ layers, a characteristic known as pluripotency. In particular, the generation of ES cell-derived hematopoietic cells could serve as an alternate source of hematopoietic stem cells for transplantation in place of bone marrow cells, which are limited by donor availability and high immunogenicity. The advantages of ES cell-derived hematopoietic cells over bone marrow cells include a greater proliferative capacity, which alleviates the problems of donor shortage, and low level expression of MHC a
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Kimura, Azuma. "Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells." Kyoto University, 2019. http://hdl.handle.net/2433/242422.

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