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Journal articles on the topic 'Ependymal stem progenitor cells'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Xing, Liujing, Teni Anbarchian, Jonathan M. Tsai, Giles W. Plant та Roeland Nusse. "Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis". Proceedings of the National Academy of Sciences 115, № 26 (2018): E5954—E5962. http://dx.doi.org/10.1073/pnas.1803297115.

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In the adult mouse spinal cord, the ependymal cell population that surrounds the central canal is thought to be a promising source of quiescent stem cells to treat spinal cord injury. Relatively little is known about the cellular origin of ependymal cells during spinal cord development, or the molecular mechanisms that regulate ependymal cells during adult homeostasis. Using genetic lineage tracing based on the Wnt target geneAxin2, we have characterized Wnt-responsive cells during spinal cord development. Our results revealed that Wnt-responsive progenitor cells are restricted to the dorsal m

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Kakogiannis, Dimitrios, Michaela Kourla, Dimitrios Dimitrakopoulos, and Ilias Kazanis. "Reversal of Postnatal Brain Astrocytes and Ependymal Cells towards a Progenitor Phenotype in Culture." Cells 13, no. 8 (2024): 668. http://dx.doi.org/10.3390/cells13080668.

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Astrocytes and ependymal cells have been reported to be able to switch from a mature cell identity towards that of a neural stem/progenitor cell. Astrocytes are widely scattered in the brain where they exert multiple functions and are routinely targeted for in vitro and in vivo reprogramming. Ependymal cells serve more specialized functions, lining the ventricles and the central canal, and are multiciliated, epithelial-like cells that, in the spinal cord, act as bi-potent progenitors in response to injury. Here, we isolate or generate ependymal cells and post-mitotic astrocytes, respectively,

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3

Burket, Noah, Jia Wang, Hongyu Gao, et al. "EPCO-60. EXPRESSION OF EARLY PROGENITOR MARKERS WITHIN NF2-ASSOCIATED SPINAL EPENDYMOMA." Neuro-Oncology 26, Supplement_8 (2024): viii15. http://dx.doi.org/10.1093/neuonc/noae165.0059.

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Abstract Spinal ependymomas (SP-EPNs) are intramedullary spinal tumors commonly found in patients with NF2-related schwannomatosis. Recent work using bulkRNA sequencing has suggested that SP-EPNs express a molecular signature most similar to ependymal cells. However, this type of sequencing may miss rare stem cell populations within tumors. The aim of this study was to assess the spatial heterogeneity within NF2-associated SP-EPNs and explore whether a stem cell population exists within SP-EPNs. Spatial transcriptomics (ST) was performed on a SP-EPN sample previously resected from a patient wi

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Mothe, Andrea J., Iris Kulbatski, Rita L. van Bendegem, et al. "Analysis of Green Fluorescent Protein Expression in Transgenic Rats for Tracking Transplanted Neural Stem/Progenitor Cells." Journal of Histochemistry & Cytochemistry 53, no. 10 (2005): 1215–26. http://dx.doi.org/10.1369/jhc.5a6639.2005.

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Green fluorescent protein (GFP) expression was evaluated in tissues of different transgenic rodents—Sprague-Dawley (SD) rat strain [SD-Tg(GFP)Bal], W rat strain [Wistar-TgN(CAG-GFP)184ys], and M mouse strain [Tg(GFPU)5Nagy/J]—by direct fluorescence of native GFP expression and by immunohistochemistry. The constitutively expressing GFP transgenic strains showed tissue-specific differences in GFP expression, and GFP immunohistochemistry amplified the fluorescent signal. The fluorescence of stem/progenitor cells cultured as neurospheres from the ependymal region of the adult spinal cord from the

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Rodriguez-Jimenez, Francisco, Ana Alastrue-Agudo, Miodrag Stojkovic, Slaven Erceg, and Victoria Moreno-Manzano. "Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation." International Journal of Molecular Sciences 16, no. 11 (2015): 26608–18. http://dx.doi.org/10.3390/ijms161125981.

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6

Rodriguez-Jimenez, Francisco Javier, Ana Alastrue, Miodrag Stojkovic, Slaven Erceg, and Victoria Moreno-Manzano. "Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells." Cell and Tissue Research 365, no. 2 (2016): 295–307. http://dx.doi.org/10.1007/s00441-016-2421-y.

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7

Finkel, Zachary, Fatima Esteban, Brianna Rodriguez, Tianyue Fu, Xin Ai, and Li Cai. "Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease." Cells 10, no. 8 (2021): 2045. http://dx.doi.org/10.3390/cells10082045.

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Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master tran

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8

Gotoh, Yukiko. "IL2 Neural stem cell regulation and brain development." Neuro-Oncology Advances 3, Supplement_6 (2021): vi1. http://dx.doi.org/10.1093/noajnl/vdab159.001.

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Abstract Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone (SVZ) are derived from a subpopulation of embryonic neural stem-progenitor cells (NPCs) that is characterized by a slower cell cycle relative to the more abundant rapid cycling NPCs that build the brain. We have previously shown that slow cell cycle can cause the establishment of adult NSCs at the SVZ, although the underlying mechanism remains unknown. We found that Notch and an effector Hey1 form a module that i

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Makrygianni, Evanthia A., and George P. Chrousos. "Neural Progenitor Cells and the Hypothalamus." Cells 12, no. 14 (2023): 1822. http://dx.doi.org/10.3390/cells12141822.

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Neural progenitor cells (NPCs) are multipotent neural stem cells (NSCs) capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. In the postnatal/adult brain, NPCs are primarily located in the subventricular zone (SVZ) of the lateral ventricles (LVs) and subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). There is evidence that NPCs are also present in the postnatal/adult hypothalamus, a highly conserved brain region involved in the regulation of core homeostatic processes, such as feeding, metabolism, reproduction, neuroendocrine integration and au

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10

Donato, Sarah V., and Matthew K. Vickaryous. "Radial Glia and Neuronal-like Ependymal Cells Are Present within the Spinal Cord of the Trunk (Body) in the Leopard Gecko (Eublepharis macularius)." Journal of Developmental Biology 10, no. 2 (2022): 21. http://dx.doi.org/10.3390/jdb10020021.

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As is the case for many lizards, leopard geckos (Eublepharis macularius) can self-detach a portion of their tail to escape predation, and then regenerate a replacement complete with a spinal cord. Previous research has shown that endogenous populations of neural stem/progenitor cells (NSPCs) reside within the spinal cord of the original tail. In response to tail loss, these NSPCs are activated and contribute to regeneration. Here, we investigate whether similar populations of NSPCs are found within the spinal cord of the trunk (body). Using a long-duration 5-bromo-2′-deoxyuridine pulse-chase e

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11

Mokhtar, Doaa M., Ramy K. A. Sayed, Giacomo Zaccone, Marco Albano, and Manal T. Hussein. "Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies." Cells 11, no. 17 (2022): 2659. http://dx.doi.org/10.3390/cells11172659.

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This study was conducted on 16 adult specimens of molly fish (Poecilia sphenops) to investigate ependymal cells (ECs) and their role in neurogenesis using ultrastructural examination and immunohistochemistry. The ECs lined the ventral and lateral surfaces of the optic ventricle and their processes extended through the tectal laminae and ended at the surface of the tectum as a subpial end-foot. Two cell types of ECs were identified: cuboidal non-ciliated (5.68 ± 0.84/100 μm2) and columnar ciliated (EC3.22 ± 0.71/100 μm2). Immunohistochemical analysis revealed two types of GFAP immunoreactive ce

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Park, Sang In, Jung Yeon Lim, Chang Hyun Jeong, et al. "Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/362473.

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Numerous studies have shown the benefits of mesenchymal stem cells (MSCs) on the repair of spinal cord injury (SCI) model and on behavioral improvement, but the underlying mechanisms remain unclear. In this study, to investigate possible mechanisms by which MSCs contribute to the alleviation of neurologic deficits, we examined the potential effect of human umbilical cord blood-derived MSCs (hUCB-MSCs) on the endogenous cell proliferation and oligogenesis after SCI. SCI was injured by contusion using a weight-drop impactor and hUCB-MSCs were transplanted into the boundary zone of the injured si

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13

Marcuzzo, Stefania, Dimos Kapetis, Renato Mantegazza, et al. "Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells." Experimental Neurology 253 (March 2014): 91–101. http://dx.doi.org/10.1016/j.expneurol.2013.12.007.

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14

Donson, Andrew, Austin Gillen, Riemondy Kent, et al. "EPEN-31. SINGLE-CELL RNAseq OF CHILDHOOD EPENDYMOMA REVEALS DISTINCT NEOPLASTIC CELL SUBPOPULATIONS THAT IMPACT ETIOLOGY, MOLECULAR CLASSIFICATION AND OUTCOME." Neuro-Oncology 22, Supplement_3 (2020): iii314. http://dx.doi.org/10.1093/neuonc/noaa222.167.

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Abstract Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in the majority of children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly confounds our understanding of EPN biology, impeding development of effective therapy. We therefore used single-cell RNA sequencing to catalog cellular heterogeneity of 26 childhood EPN, predominantly from ST-RELA, PFA1 and PFA2 subgroups. ST-RELA and PFA subgroups clustered separately, with ST-RELA clustering largely according to individual sample-of-origin. PFA1 and PFA2 subgroup EPNs cells were in

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15

Redmond, Stephanie A., María Figueres-Oñate, Kirsten Obernier, et al. "Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor." Cell Reports 27, no. 2 (2019): 429–41. http://dx.doi.org/10.1016/j.celrep.2019.01.088.

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16

Mitra, Siddhartha S., Abdullah H. Feroze, Sharareh Gholamin, et al. "Neural Placode Tissue Derived From Myelomeningocele Repair Serves as a Viable Source of Oligodendrocyte Progenitor Cells." Neurosurgery 77, no. 5 (2015): 794–802. http://dx.doi.org/10.1227/neu.0000000000000918.

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Abstract BACKGROUND: The presence, characteristics, and potential clinical relevance of neural progenitor populations within the neural placodes of myelomeningocele patients remain to be studied. Neural stem cells are known to reside adjacent to ependyma-lined surfaces along the central nervous system axis. OBJECTIVE: Given such neuroanatomic correlation and regenerative capacity in fetal development, we assessed myelomeningocele-derived neural placode tissue as a potentially novel source of neural stem and progenitor cells. METHODS: Nonfunctional neural placode tissue was harvested from infan

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17

Lucini, Carla, and Claudia Gatta. "Glial Diversity and Evolution: Insights from Teleost Fish." Brain Sciences 15, no. 7 (2025): 743. https://doi.org/10.3390/brainsci15070743.

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Glial cells, once considered mere support for neurons, have emerged as key players in brain function across vertebrates. The historical study of glia dates to the 19th century with the identification of ependymal cells and astrocytes, followed by the discovery of oligodendrocytes and microglia. While neurocentric perspectives overlooked glial functions, recent research highlights their essential roles in neurodevelopment, synapse regulation, brain homeostasis, and neuroimmune responses. In teleost fish, a group comprising over 32,000 species, glial cells exhibit unique properties compared to t

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18

Shinozuka, Takuma, and Shinji Takada. "Morphological and Functional Changes of Roof Plate Cells in Spinal Cord Development." Journal of Developmental Biology 9, no. 3 (2021): 30. http://dx.doi.org/10.3390/jdb9030030.

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The most dorsal region, or roof plate, is the dorsal organizing center of developing spinal cord. This region is also involved in development of neural crest cells, which are the source of migratory neural crest cells. During early development of the spinal cord, roof plate cells secrete signaling molecules, such as Wnt and BMP family proteins, which regulate development of neural crest cells and dorsal spinal cord. After the dorso-ventral pattern is established, spinal cord dynamically changes its morphology. With this morphological transformation, the lumen of the spinal cord gradually shrin

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Marcuzzo, Stefania, Davide Isaia, Silvia Bonanno, et al. "FM19G11-Loaded Gold Nanoparticles Enhance the Proliferation and Self-Renewal of Ependymal Stem Progenitor Cells Derived from ALS Mice." Cells 8, no. 3 (2019): 279. http://dx.doi.org/10.3390/cells8030279.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. In ALS mice, neurodegeneration is associated with the proliferative restorative attempts of ependymal stem progenitor cells (epSPCs) that normally lie in a quiescent in the spinal cord. Thus, modulation of the proliferation of epSPCs may represent a potential strategy to counteract neurodegeneration. Recent studies demonstrated that FM19G11, a hypoxia-inducible factor modulator, induces epSPC self-renewal and proliferation. The aim of the study was to investigate whether FM19G11-loaded gold

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20

McDonough, Ashley, and Verónica Martínez-Cerdeño. "Endogenous Proliferation after Spinal Cord Injury in Animal Models." Stem Cells International 2012 (2012): 1–16. http://dx.doi.org/10.1155/2012/387513.

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Spinal cord injury (SCI) results in motor and sensory deficits, the severity of which depends on the level and extent of the injury. Animal models for SCI research include transection, contusion, and compression mouse models. In this paper we will discuss the endogenous stem cell response to SCI in animal models. All SCI animal models experience a similar peak of cell proliferation three days after injury; however, each specific type of injury promotes a specific and distinct stem cell response. For example, the transection model results in a strong and localized initial increase of proliferat

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21

Mothe, A. J., and C. H. Tator. "Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat." Neuroscience 131, no. 1 (2005): 177–87. http://dx.doi.org/10.1016/j.neuroscience.2004.10.011.

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22

Hachem, LD, J. Hong, A. Velumian, AJ Mothe, CH Tator, and MG Fehlings. "GR.6 Harnessing the endogenous regenerative potential of the injured spinal cord." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 50, s2 (2023): S47. http://dx.doi.org/10.1017/cjn.2023.75.

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Background: The adult spinal cord contains a population of ependymal-derived neural stem/progenitor cells (epNSPCs) with the potential to enhance endogenous regeneration. However, little is known about the mechanisms that regulate the activation of these cells after injury. Recently, we discovered that glutamate excitotoxicity, a hallmark in the pathophysiology of acute SCI, promotes epNSPC proliferation/survival. Here, we characterize the downstream signaling pathways involved in this response and target this mechanism in vivo to enhance the endogenous regenerative capacity of these cells. Me

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Horiguchi, Kotaro, Saishu Yoshida, Rumi Hasegawa, et al. "Isolation and characterization of cluster of differentiation 9-positive ependymal cells as potential adult neural stem/progenitor cells in the third ventricle of adult rats." Cell and Tissue Research 379, no. 3 (2019): 497–509. http://dx.doi.org/10.1007/s00441-019-03132-5.

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24

Gómez-Villafuertes, Rosa, Francisco Javier Rodríguez-Jiménez, Ana Alastrue-Agudo, Miodrag Stojkovic, María Teresa Miras-Portugal, and Victoria Moreno-Manzano. "Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury." Cell Transplantation 24, no. 8 (2015): 1493–509. http://dx.doi.org/10.3727/096368914x682828.

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Hachem, LD, H. Moradi, G. Balbinot, et al. "F.5 A neurotransmitter-dependent mechanism of ependymal cell activation: Insights into a novel therapeutic target for spinal cord injury." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 51, s1 (2024): S13. http://dx.doi.org/10.1017/cjn.2024.107.

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Background: The drivers that activate endogenous ependymal-derived neural stem/progenitor cells (epNSPCs) remain unknown. Understanding the mechanisms that govern the biology of these cells is critical in developing a therapeutic strategy to harness their regenerative potential after injury. Methods: FoxJ1-CreER-tdTomato reporter mice were used for epNSPC lineage tracing. A conditional genetic knock-out mouse line of glutamate-subtype AMPA receptor (AMPAR) subunits in epNSPCs was generated. Electrophysiological properties were assessed using single cell patch clamp and slice culture recordings

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Hachem, Laureen D., James Hong, Alexander Velumian, Andrea Mothe, Charles Tator, and Michael G. Fehlings. "250 Harnessing the Endogenous Stem Cell Response After Spinal Cord Injury: A Novel and Translationally Relevant Therapeutic Strategy." Neurosurgery 70, Supplement_1 (2024): 69. http://dx.doi.org/10.1227/neu.0000000000002809_250.

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INTRODUCTION: The adult spinal cord contains a population of endogenous ependymal-derived neural stem/progenitor cells (epNSPCs) that hold the potential to promote regeneration and repair after injury. epNSPCs are normally quiescent but are acutely activated after spinal cord injury (SCI). Despite this, the activation of these cells remains insufficient to promote robust neural regeneration and recovery. Understanding the mechanisms that govern the biology of epNSPCs is critical in developing a therapeutic strategy to harness their regenerative potential after SCI. METHODS: epNSPCs isolated fr

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Jeong, Daeun, Sara G. Danielli, Kendra Maaß, et al. "STEM-11. MULTIDIMENSIONAL PROFILING OF TUMOR CELL HETEROGENEITY REVEALS CELL-LINEAGE SPECIFIC FUNCTIONS IN SUPRATENTORIAL EPENDYMOMAS." Neuro-Oncology 26, Supplement_8 (2024): viii60. http://dx.doi.org/10.1093/neuonc/noae165.0237.

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Abstract Supratentorial ependymomas (ST-EPN) are aggressive pediatric brain tumors that are categorized into distinct molecular subgroups. However, the developmental origins, tumor microenvironment, and phenotypic characteristics of tumor subpopulations across these subgroups are still poorly understood. In this study, we explored the human developmental signatures, global spatial organization, and the morphological and migratory tumor cell state behaviors in ST-EPN tumors at unprecedented resolution. We profiled 42 ST-EPN patients encompassing ZFTA-RELA (n = 20), ZFTA-Clusters 1 to 4 (n=20),

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Wittmann, Gabor, Surbhi Gahlot, Malcolm James Low, and Ronald M. Lechan. "Rax Expression Identifies a Novel Cell Type in the Adult Mouse Hypothalamus." Journal of the Endocrine Society 5, Supplement_1 (2021): A42. http://dx.doi.org/10.1210/jendso/bvab048.082.

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Abstract Hypothalamic tanycytes are radial glia-like ependymal cells lining the ventrolateral walls and floor of the third ventricle. Recent data show that tanycytes are adult neural stem/progenitor cells, capable of generating neurons that populate the adjacent hypothalamic nuclei involved in the regulation of feeding and energy balance. Thus, the genetic fate mapping of tanycytes has become an invaluable tool to identify and study tanycyte-derived adult-born hypothalamic neurons. Perhaps the most selective tanycyte marker identified to date is the retina and anterior neural fold homeobox (Ra

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Henzi, Roberto, Montserrat Guerra, Karin Vío, et al. "Neurospheres from neural stem/neural progenitor cells (NSPCs) of non-hydrocephalic HTx rats produce neurons, astrocytes and multiciliated ependyma: the cerebrospinal fluid of normal and hydrocephalic rats supports such a differentiation." Cell and Tissue Research 373, no. 2 (2018): 421–38. http://dx.doi.org/10.1007/s00441-018-2828-8.

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Ribeiro, Ana, Joana F. Monteiro, Ana C. Certal, Ana M. Cristovão, and Leonor Saúde. "Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish." Open Biology 7, no. 11 (2017): 170139. http://dx.doi.org/10.1098/rsob.170139.

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Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of t

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Mokrý, Jaroslav, and J. Karbanová. "Foetal Mouse Neural Stem Cells Give Rise to Ependymal Cells in Vitro." Folia Biologica 52, no. 5 (2006): 149–55. https://doi.org/10.14712/fb2006052050149.

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NSCs are responsible for the generation of CNS cell types derived from the neural tube. Published data resulting from experiments studying the differentiation of NSCs in vitro or in vivo have confirmed their spontaneous tripotency, i.e. their ability to generate cells of the neuronal, astroglial and oligodendroglial lineages. The relationship between NSCs generated in vitro and ependymal cells has not yet been studied. To confirm that ependymal cells can also be produced by NSCs, we utilized the neurosphere assay, which permits isolation and cultivation of NSCs. Cells from the forebrain of E14

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Itokazu, Yutaka, Masaaki Kitada, Mari Dezawa, et al. "Choroid plexus ependymal cells host neural progenitor cells in the rat." Glia 53, no. 1 (2005): 32–42. http://dx.doi.org/10.1002/glia.20255.

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Rao, Shilpa, Niveditha Ravindra, Nishanth Sadashiva, Bhagavatula Indira Devi, and Vani Santosh. "Anaplastic Ependymoma With Ganglionic Differentiation: Report of a Rare Case and Implications in Diagnosis." International Journal of Surgical Pathology 25, no. 7 (2017): 644–47. http://dx.doi.org/10.1177/1066896917710716.

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Ependymomas are glial neoplasms with rare cases exhibiting neuronal differentiation. We describe a case of spinal anaplastic ependymoma with ganglionic differentiation in a 28-year-old woman. The ganglionic component was labeled by synaptophysin, whereas the rest of the tumor showed features of an anaplastic ependymoma. Stem cell marker MELK was noted to stain both the neoplastic ependymal and ganglionic components, possibly suggesting a stem cell/progenitor origin for the tumor with subsequent divergent differentiation.

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YÜKSEL, Hasan, and Emre ZAFER. "Endometrial Stem/Progenitor Cells." Current Obstetrics and Gynecology Reports 9, no. 1 (2020): 7–14. http://dx.doi.org/10.1007/s13669-020-00278-w.

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Maruyama, Tetsuo. "Endometrial stem/progenitor cells." Journal of Obstetrics and Gynaecology Research 40, no. 9 (2014): 2015–22. http://dx.doi.org/10.1111/jog.12501.

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Yoder, Mervin C. "Endothelial stem and progenitor cells (stem cells): (2017 Grover Conference Series)." Pulmonary Circulation 8, no. 1 (2017): 204589321774395. http://dx.doi.org/10.1177/2045893217743950.

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The capacity of existing blood vessels to give rise to new blood vessels via endothelial cell sprouting is called angiogenesis and is a well-studied biologic process. In contrast, little is known about the mechanisms for endothelial cell replacement or regeneration within established blood vessels. Since clear definitions exist for identifying cells with stem and progenitor cell properties in many tissues and organs of the body, several groups have begun to accumulate evidence that endothelial stem and progenitor cells exist within the endothelial intima of existing blood vessels. This paper w

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Moreno-Manzano, Victoria, Francisco Javier Rodríguez-Jiménez, Mireia García-Roselló, et al. "Activated Spinal Cord Ependymal Stem Cells Rescue Neurological Function." Stem Cells 27, no. 3 (2009): 733–43. http://dx.doi.org/10.1002/stem.24.

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Pinto do Ó, Perpétua, Karin Richter, and Leif Carlsson. "Hematopoietic progenitor/stem cells immortalized byLhx2 generate functional hematopoietic cells in vivo." Blood 99, no. 11 (2002): 3939–46. http://dx.doi.org/10.1182/blood.v99.11.3939.

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Hematopoietic stem cells (HSCs) are unique in their capacity to maintain blood formation following transplantation into immunocompromised hosts. Expansion of HSCs in vitro is therefore important for many clinical applications but has met with limited success because the mechanisms regulating the self-renewal process are poorly defined. We have previously shown that expression of the LIM-homeobox gene Lhx2 in hematopoietic progenitor cells derived from embryonic stem cells differentiated in vitro generates immortalized multipotent hematopoietic progenitor cell lines. However, HSCs of early embr

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Wang, Xusehng. "Stem/Progenitor Cells in Skin." Journal of Stem Cells Research, Development & Therapy 5, no. 1 (2019): 1–5. http://dx.doi.org/10.24966/srdt-2060/100016.

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Pittatore, G., A. Moggio, C. Benedetto, B. Bussolati, and A. Revelli. "Endometrial Adult/Progenitor Stem Cells." Reproductive Sciences 21, no. 3 (2013): 296–304. http://dx.doi.org/10.1177/1933719113503405.

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Ardhanareeswaran, Karthikeyan, and Maria Mirotsou. "Lung Stem and Progenitor Cells." Respiration 85, no. 2 (2013): 89–95. http://dx.doi.org/10.1159/000346500.

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Chevreau, Robert, Hussein Ghazale, Chantal Ripoll, et al. "RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate." Cells 10, no. 12 (2021): 3332. http://dx.doi.org/10.3390/cells10123332.

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Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They proliferate after spinal cord injury and produce neurons in lower vertebrates but predominantly astrocytes in mammals. The mechanisms underlying this glial-biased differentiation remain ill-defined. We addressed this issue by generating a molecular resource through RNA profiling of ependymal cells before and after injury. We found that these cells activate STAT3 and ERK/MAPK signaling post injury and downregulate cilia-associated genes and FOXJ1, a central transcription factor in ciliogenesis. Conve

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Zhou, Li-li, Wei Liu, Yan-min Wu, Wei-lian Sun, C. E. Dörfer, and K. M. Fawzy El-Sayed. "Oral Mesenchymal Stem/Progenitor Cells: The Immunomodulatory Masters." Stem Cells International 2020 (February 25, 2020): 1–16. http://dx.doi.org/10.1155/2020/1327405.

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Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progenitor cells from human exfoliated deciduous teeth (SHED), the gingival mesenchymal stem/progenitor cells (GMSCs), the stem/progenitor cells from the apical papilla (SCAP), the dental follicle stem/progenitor cells (DFSCs), the bone marrow mesenchymal stem/progenitor cells (BM-MSCs)

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Fu, Hui, Yingchuan Qi, Min Tan, et al. "Molecular mapping of the origin of postnatal spinal cord ependymal cells: Evidence that adult ependymal cells are derived from Nkx6.1+ ventral neural progenitor cells." Journal of Comparative Neurology 456, no. 3 (2003): 237–44. http://dx.doi.org/10.1002/cne.10481.

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Farrugia, Georgiana, and Rena Balzan. "Stem Cell Repair for Cardiac Muscle Regeneration: A Review of the Literature." International Journal of Medical Students 4, no. 1 (2016): 19–25. http://dx.doi.org/10.5195/ijms.2016.145.

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The notion that the human adult heart is a quiescent organ incapable of self-regeneration has been successfully challenged. It is now evident that the heart possesses a significant ability for repair and regeneration. Stem cells of endogenous cardiac origin are currently considered to possess the greatest ability to differentiate into cardiomyocytes. The major types of cardiac stem cells that show a promising potential to replace damaged cardiomyocytes include C-KIT positive (C-KIT+) cardiac progenitor cells, cardiosphere-derived progenitor cells, islet-1 (Isl1+) cardiac progenitor cells, side

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Alshoubaki, Yasmin K., Bhavana Nayer, Surojeet Das, and Mikaël M. Martino. "Modulation of the Activity of Stem and Progenitor Cells by Immune Cells." Stem Cells Translational Medicine 11, no. 3 (2022): 248–58. http://dx.doi.org/10.1093/stcltm/szab022.

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Abstract Numerous components of the immune system, including inflammatory mediators, immune cells and cytokines, have a profound modulatory effect on the homeostatic regulation and regenerative activity of endogenous stem cells and progenitor cells. Thus, understanding how the immune system interacts with stem/progenitor cells could build the foundation to design novel and more effective regenerative therapies. Indeed, utilizing and controlling immune system components may be one of the most effective approaches to promote tissue regeneration. In this review, we first summarize the effects of

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Yang, Dong-Rong, Xian-Fan Ding, Jie Luo, et al. "Increased Chemosensitivity via Targeting Testicular Nuclear Receptor 4 (TR4)-Oct4-Interleukin 1 Receptor Antagonist (IL1Ra) Axis in Prostate Cancer CD133+ Stem/Progenitor Cells to Battle Prostate Cancer." Journal of Biological Chemistry 288, no. 23 (2013): 16476–83. http://dx.doi.org/10.1074/jbc.m112.448142.

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Prostate cancer (PCa) stem/progenitor cells are known to have higher chemoresistance than non-stem/progenitor cells, but the underlying molecular mechanism remains unclear. We found the expression of testicular nuclear receptor 4 (TR4) is significantly higher in PCa CD133+ stem/progenitor cells compared with CD133− non-stem/progenitor cells. Knockdown of TR4 levels in the established PCa stem/progenitor cells and the CD133+ population of the C4-2 PCa cell line with lentiviral TR4 siRNA led to increased drug sensitivity to the two commonly used chemotherapeutic drugs, docetaxel and etoposide, j

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Zhao, Xiangshan, Gautam K. Malhotra, Hamid Band, and Vimla Band. "Derivation of Myoepithelial Progenitor Cells from Bipotent Mammary Stem/Progenitor Cells." PLoS ONE 7, no. 4 (2012): e35338. http://dx.doi.org/10.1371/journal.pone.0035338.

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Copland, Mhairi, Francesca Pellicano, Linda Richmond, et al. "BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors." Blood 111, no. 5 (2008): 2843–53. http://dx.doi.org/10.1182/blood-2007-09-112573.

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Chronic myeloid leukemia (CML), a hematopoietic stem-cell disorder, cannot be eradicated by conventional chemotherapy or the tyrosine kinase inhibitor imatinib mesylate (IM). To target CML stem/progenitor cells, we investigated BMS-214662, a cytotoxic farnesyltransferase inhibitor, previously reported to kill nonproliferating tumor cells. IM or dasatinib alone reversibly arrested proliferation of CML stem/progenitor cells without inducing apoptosis. In contrast, BMS-214662, alone or in combination with IM or dasatinib, potently induced apoptosis of both proliferating and quiescent CML stem/pro

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Sugimura, Ryohichi, Deepak Kumar Jha, Areum Han, et al. "Haematopoietic stem and progenitor cells from human pluripotent stem cells." Nature 545, no. 7655 (2017): 432–38. http://dx.doi.org/10.1038/nature22370.

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