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Dissertations / Theses on the topic 'Epidermal growth factor pathway'

Author: Grafiati

Published: 7 September 2021

Last updated: 29 July 2025

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1

Mayawala, Kapil. "Spatiotemporal modeling of epidermal growth factor receptor signaling pathway." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 2.14 Mb., 263 p, 2006. http://wwwlib.umi.com/dissertations/fullcit/3220795.

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2

Wasserman, Jonathan Daniel. "Pattern formation in Drosophila : roles of the EGF receptor pathway." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624214.

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3

Kleiman, Laura B. "Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57796.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 157-168).<br>The epidermal growth factor receptor (EGFR, also known as ErbB 1) is a prototypical receptor tyrosine kinase (RTK) that activates multi-kinase phosphorylation cascades to regulate diverse cellular processes, including proliferation, migration and differentiation. ErbB 1 heterooligomerizes with three close homologues: ErbB2, ErbB3 and ErbB4. ErbB1-3 receptors are frequently mutated, overexpressed

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4

Ho, Ka-yan Rebecca Lucinda, and 何嘉茵. "Mutations of epidermal growth factor receptor (EGFR) pathway genes andMET in primary lung adenocarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48333906.

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This study completed the analysis of mutational frequencies and clinicopathological patterns of six EGFR pathway-related genes (EGFR, HER2, HER4, KRAS, BRAF and MET) in 212 resected lung adenocarcinomas (AD) from 98 male and 114 female Chinese patients without prior chemotherapy or tyrosine kinase inhibitor (TKI) therapy. Genomic DNA and cDNA sequencing, quantitative PCR and fluorescence in-situ hybridization (FISH) were employed to investigate mutation and amplification status of the relevant genes. Overall, more than 75% of tumours were detected to harbour mutations or amplification in one

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5

Jordan, Katherine C. "Patterning the Drosophila eggshell and embryo through the interaction of the epidermal growth factor receptor and notch pathways /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5036.

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6

Shea, Ka-hon Graham, and 佘嘉翰. "ErbB receptor modulation by the Notch pathway as a means to fate commitment in bone marrow-derived Schwann cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46083042.

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7

Chen, Fangli 1968. "Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8579.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.<br>Includes bibliographical references.<br>Split ends (spen) was isolated as a strong enhancer of the rough eye phenotype associated with constitutive activation of Yan, implicating spen as a positive regulator of the receptor tyrosine kinase (RTK) signaling pathway. Molecular characterization of spen has revealed that spen encodes a protein with 5476 amino acids. It contains three tandem repeats of an RNA Recognition Motif (RRM) at its N-terminus, suggesting that Spen might function as an RNAbinding protein. Spen a

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8

Davidson, Bruce Paul, University of Western Sydney, and School of Biological Sciences. "Compound mutations in the mammalian EGFR signalling pathway affect epidermal development, growth and viability." THESIS_XXXX_SBS_Davidson_B.xml, 1997. http://handle.uws.edu.au:8081/1959.7/518.

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The widespread expression of polypeptide growth factors from the earliest stages of embryonic development through to mature issues in the adult organism suggests an involvement in a reiterated developmental process affecting the underlying cellular growth and differentiation of many tissues. The hair follicle has taken on increased significance with the observation that many genetic mutations in these peptide growth factor genes affect its development. The targeted disruption of genes encoding members of the EpidermalGrowth Factor (EGF) and Fibroblast Growth Factor (FGF) families in the mouse

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9

So, Kam-ting. "Mutations in epidermal growth factor receptor-related pathways in non-small cell lung cancer." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085313.

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10

Dai, Yumin. "Phytochemicals from Graviola fruit selectively inhibit breast cancer cells growth involving EGFR signaling pathway." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/41892.

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There is a growing interest in using naturally-occurring compounds as cancer chemopreventive or chemotherapeutic agents. This study investigated the anticancer potential of the graviola fruit extract (GFE) on specific human breast cancer (BC) cells. GFE was found in our preliminary screening to selectively inhibit the growth of certain human BC cells (MDA-MB-468) but did not affect non-transformed breast epithelial MCF-10A cells. GFE treatment was very effective against the growth of MDA-MB-468 BC cells with an IC50 of 4.8 Âµg/ml. In vitro, effects of GFE treatment on MDA-MB-468 BC cells were

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11

Zainal, H. B. "Targeting the epidermal growth factor receptor (EGFR) pathway for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1477184/.

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Kidney enlargement and cyst formation is the hallmark presentation of Autosomal Dominant Polycystic Kidney Disease (ADPKD). To date, only one treatment has been approved in Europe and the UK for a small subset of patients to slow down cyst growth. EGFR(ErbB1)/ErbB2 complexes, which are not expressed in normal adult kidney tubules, have been found to be highly expressed on the apical membrane of epithelium lining the cysts. Studies have shown that EGFR(ErbB1) and ErbB2 inhibitors significantly reduce cyst expansion and reverse the ADPKD phenotype in vitro and in vivo. This project is aimed at d

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12

Truesdell, Sharon. "Analysis of cell types in continuous cell lines and analysis of the Epidermal Growth Factor Receptor pathway in Drosophila." Connect to resource, 2009. http://hdl.handle.net/1811/37280.

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13

Davidson, Bruce Paul. "Compound mutations in the mammalian EGFR signalling pathway affect epidermal development, growth and viability /." View thesis, 1997. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030826.115144/index.html.

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14

So, Kam-ting, and 蘇淦庭. "Mutations in epidermal growth factor receptor-related pathways in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085313.

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15

Valiathan, Rajeshwari Rajan. "Functional interactions of HIV-1 GAg with the cellular endocytic pathway /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1481666381&sid=16&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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16

Kay, Denis G. "Studies on the pathway and significance of the receptor mediated internalization of insulin and epidermal growth factor in rat liver parenchyma." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75441.

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The pathway of internalization of insulin and asialoglycoprotein into rat liver parenchymal cells was through the same endosomal components. At no time was either ligand associated with the biosynthetic Golgi apparatus. Rat liver Golgi fractions were found to be contaminated by endosomes, hence their redesignation as Golgi-endosome fractions (GE).<br>Proton translocation activity of different GE fractions showed a gradient of progressively decreasing activity which correlated with increasing time, of ligand accumulation therein. Based on the distinctive kinetics of proton translocation activit

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17

Mukhtar, Lenah. "Targeting the Mevalonate Pathway Enhances the Efficacy of Epidermal Growth Factor Receptor – Tyrosine Kinase Inhibitors in Head and Neck Squamous Cell Carcinoma." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40391.

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Epidermal growth factor receptor (EGFR) is highly expressed in head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC) and is a key regulator of tumor cell growth and survival. Erlotinib, also known as tarceva, (a first-generation) and afatinib, also known as giotrif, (a second-generation) are tyrosine kinase inhibitors (TKIs) of EGFR. These TKIs are recognized therapeutic agents in these tumor types, as they inhibit EGFR signaling but show limited activity as single agents. Novel strategies will likely require EGFR-TKIs combination with an agent(s) that will enhan

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18

Donepudi, Manjula. "The regulation of calbindin D-28K by epidermal growth factor in MDBK cells and the involvement of signal transduction pathways." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9962.

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We investigated the ability of 1,25(OH)$\rm\sb2D\sb3$ and EGF to modulate cell proliferation and VDR levels in renal distal tubular cells. As well, we characterized the effects of EGF on the vitamin D-dependent calcium binding protein calbindin D-28K in order to determine if changes in its expression were linked to cell proliferation. The MDBK cells represent an ideal in vitro system for studying the regulation of calbindin D-28K and VDR since both proteins are expressed in a 1,25(OH)$\rm\sb2D\sb3$-dependent manner in these cells. Assessment of DNA synthesis, cell cycle kinetics and cell numbe

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19

Wirth, Pamela. "THE PROGNOSTIC POTENTIAL OF THE EPIDERMAL GROWTH FACTOR RECEPTOR AND NUCLEAR FACTOR KAPPA B PATHWAYS AND ASSOCIATED THERAPEUTIC STRATEGIES IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2229.

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Little is known about the signaling pathways that contribute to treatment response in advanced stage head and neck tumors. Increased expression of epidermal growth factor receptor (EGFR) and downstream pathways such as nuclear factor kappa B (NFκB) are implicated in aggressive tumor phenotypes and limited response to therapy. This study explored the rationale for combining the proteasome inhibitor bortezomib with the EGFR inhibitor gefitinib in a subset of head and neck squamous cell carcinomas with high EGFR gene amplification. Drug responses of gefitinib and bortezomib as single agents and i

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20

Pourazar, Jamshid. "Activation of epithelial signal transduction pathways, cytokine production and airway inflammation following diesel exhaust exposure." Doctoral thesis, Umeå : Department of Public Health and Clinical Medicine, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-795.

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21

Koon, Ho Kee. "Role of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinases (MAPKs) signaling pathways in Zn-BC-AM photodynamic therapy-induced apoptosis of the well-differentiated nasopharyngeal carcinoma cell." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/997.

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22

Zahr, Stephanie. "GGTI-298 in Combination with EGFR Inhibitors: Evaluating a Novel Therapy in Head and Neck Squamous Cell Carcinomas." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/25488.

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Overall survival of the metastatic forms of epithelial derived cancers, especially head and neck squamous cell carcinomas (HNSCC), has not significantly improved even with the application of aggressive combined modality approaches incorporating radiation and chemotherapy. Cumulative evidence implicates the epidermal growth factor receptor (EGFR) as an important therapeutic target in HNSCC. We have previously demonstrated that the combination of lovastatin, a potent inhibitor of the mevalonate pathway, with EGFR tyrosine kinase inhibitors induced robust synergistic cytotoxicity. However, the us

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23

Rocha, Joana Fernandes da. "Characterizing Alzeimer's amyloid precursor protein (APP) neurotrophic functions." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22225.

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Doutoramento em Biomedicina<br>The Amyloid Precursor Protein (APP) is a type 1 membrane glycoprotein, mainly known as the precursor of the amyloid β-peptide, a central player in Alzheimer’s disease. Nevertheless, APP has been established as a neuromodulator of developing and mature nervous system. Alterations in the level or activity of APP and APP fragments seem to play a critical role in several neurodegenerative and neurodevelopment disorders. APP is a complex molecule due to the intricate relationships between its intracellular trafficking, posttranslational modifications, proteolyt

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24

Aksamitienė, Edita. "Skirstymo baltymo GAB1 svarba epidermio augimo veiksnio receptoriaus signalo perdavimui." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20080130_090537-84750.

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Darbo tikslas nustatyti skirstymo baltymo GAB1 ryšį su anti-apoptoziniu PI3K/Akt bei mitogeniniu Ras/MAPK signalo perdavimo keliais ir įvertinti GAB1 įtaką šių kelių sąveikai EGFR signalo perdavimo tinkle. Darbo uždaviniai: įvertinti epitelinių ląstelių endogeninio GAB1 veiksmingumą EGF signalo perdavimo metu; nustatyti sąveikos pobūdį tarp PI3K/Akt ir Ras/MAPK kelių EGF signalo metu; kiekybiškai įvertinti GAB1 svarbą EGF signalo perdavimui per PI3K/Akt ir Ras/MAPK kelių in vivo, rezultatus lyginant su matematinio modelio prognozėmis in silico; nustatyti GAB1 veiksmingumo ir jo reguliacijos gr

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25

Eimer, Sandrine. "Etude des réponses induites par l’erlotinib dans des cellules de lignées de glioblastome." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21822/document.

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Le glioblastome (GBM), tumeur de plus haut grade du système nerveux central (OMS grade 4) a un pronostic très sombre, quelque soit le traitement, lié à une résistance à l’apoptose. L’erlotinib (Tarceva®, OSI 774) est un inhibiteur de la tyrosine kinase du récepteur au facteur de croissance épithélial (EGFR). L’hyper-expression et l’amplification du gène de l’EGFR dans 40 à 60% des GBM, fourni un rationnel pour utiliser l’erlotinib. Nous avons montré sur U87-MG et DBTRG-05MG, deux lignées de GBM, l’absence d’apoptose avec l’erlotinib, liée soit à un déficit en pro-caspase 3, soit à une accumula

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26

Porteous, C. "Epidermal growth factor, α-transforming growth factor and breast cancer". Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383650.

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Evidence exists that epidermal growth factor (EGF) and alpha transforming growth factor (αTGF) are important in breast cancer. An inverse relationship between epidermal growth factor receptor (EGF-R) and oestrogen receptor (ER) has been reported by some, (1) but not all workers (2). The aim in this thesis was to develop assays to measure, levels of EGF, and determine EGF-R status in human breast tumours. These results were then correlated with each other, with ER and node status and histological grade (Bloom & Richardson). An additional aim in this thesis was to develop a source of αTGF in con

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27

Hill, David Neale. "Probing epidermal growth factor receptor recognition." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315356.

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28

Richter, Audrey. "Studies on the interaction of the epidermal growth factor receptor with epidermal growth factor and transforming growth factor alpha to aid development of a growth factor antagonist." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387049.

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29

Chaffey, C. M. "The effects of epidermal growth factor on muscle growth." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306697.

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30

Panosa, Roqueta Clara. "Antitumoral properties of epidermal growth factor derivatives." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/369050.

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The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that inactivate the ErbB receptors through novel strategies is an important goal on cancer research. In this thesis work we have developed a shorter form of human EGF (EGFt) with a truncated C-terminal as a novel EGFR inhibitor. EGFt was designed based on the superimposition of the three-dimensional structures of EGF and the Potato Carboxypeptidase Inhibitor (PCI), an EGFR blocker pr

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31

Dudgeon, Timothy John. "Structure - function relationships in epidermal growth factor." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302727.

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32

Su, Hsing-Chih. "Role of epidermal growth factor in human parturition : betamimetic modulation of epidermal growth factor action in human amnion- derived cells /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu148775943632546.

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33

Taggart, Clifford. "Structure-function studies on human epidermal growth factor." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241494.

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34

Sainsbury, J. R. C. "Epidermal growth factor receptors and human breast cancer." Thesis, University of Newcastle Upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371259.

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35

Peron, Marie-Christine. "Epidermal growth factor (EGF)et développement foeto-placentaire." Paris 5, 1993. http://www.theses.fr/1993PA05P097.

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36

Chia, Choy May. "Epidermal growth factor (EGF) : transforming growth factor alpha (TGF-#alpha#) in human preimplantation development." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362631.

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37

Mason, Joanne Nicola. "Biosynthesis and post-translational processing of heparin-binding epidermal growth factor-like growth factor." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621007.

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38

黃穎泉 and Wing-chuen Richard Wong. "Stunted growth and infertility in transgenic mice overexpressing epidermal growth factor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223692.

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39

Wong, Wing-chuen Richard. "Stunted growth and infertility in transgenic mice overexpressing epidermal growth factor /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21301128.

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40

Nishi, Eiichiro. "Lysophosphatidylcholine increases expression of heparin-binding epidermal growth factor-like growth factor in human Tlymphocytes." Kyoto University, 1997. http://hdl.handle.net/2433/202222.

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41

Ohlsson, Bodil. "Regulation of digestive organ growth an experimental study on the role of CCK, Bile and EGF /." Lund : Dept. of Surgery, Lund University, 1996. http://books.google.com/books?id=P_9qAAAAMAAJ.

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42

Carlin, Sean Denis. "The radiotherapeutic potential of the epidermal growth factor receptor." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267078.

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43

Gaida, Annette. "Targeting epidermal growth factor receptor by ligand inspired design." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-55201.

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44

Klingbeil, Candice K. "Structure and function studies of epidermal growth factor receptor /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9901439.

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45

Rodgers, Stephen D. "Characterizing the motogenic response of human keratinocytes to epidermal growth factor and transforming growth factor-alpha." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/40610.

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46

梁永章 and Wing-cheung Tommy Leung. "A study of anti-mitogenic mechanism of epidermal growth factor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31238889.

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47

Vailes, McCauley T. "Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86273.

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The high incidence of pregnancy loss is a major issue facing the cattle industry. Use of in vitro fertilized (IVF) bovine embryos has become increasingly popular to help alleviate several of these reproductive issues and provide a means to enhance genetic gain for production traits. An uterine paracrine factor cocktail containing epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo development and trophectoderm cell numbers. The objectiv

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48

Davis, Jason A. "Molecular studies of epidermal growth factor like domains in CRB1." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413077.

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49

Timms, John Francis. "Structural and functional studies of the epidermal growth factor receptor." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294352.

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50

Maidment, Jill M. "Epidermal growth factor receptor signalling in human lens epithelial cells." Thesis, University of East Anglia, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405684.

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