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Relevant bibliographies by topics / Epidermis

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Academic literature on the topic 'Epidermis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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Journal articles on the topic "Epidermis"

1

Uplaonkar, Shilpa V., Mandakini Tengli, Syeda Farheen, and Pratima S. "Histopathological Study of Tumours of Epidermis and Epidermal Appendages." Indian Journal of Pathology: Research and Practice 6, no. 2 (Part-2) (2017): 460–66. http://dx.doi.org/10.21088/ijprp.2278.148x.62(pt-ii)17.22.

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Bogdanova, I. O., and L. A. Kartseva. "Leaf epidermal structure of extant gnetales (Gnetum L.) and the Middle Jurassic bennettitales (Nilssoniopteris Nathorst and Ptilophyllum Morris)." Palaeobotany 12 (2021): 56–87. http://dx.doi.org/10.31111/palaeobotany/2021.12.56.

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The leaf epidermis of four species of Gnetum L. and four species of the Jurassic Bennettitales (Nilssoniopteris Nathorst and Ptilophyllum Morris) were studied. In addition to the description of qualitative characters, the analysis of various quantitative characters was carried out using statistical methods. Coefficients of variation for quantitative characters of the epidermal structure in Gnetum range from 6.4 to 24.0%, in Ptilophyllum from 15.7 to 63.5%, in Nilssoniopteris from 18.0 to 39.9%. The sinuosity of tangential cell walls of the epidermal cells in the upper and lower epidermis is th

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DESAI, Rinku Jitendrakumar, Vinay Madhukar RAOLE, and Arun Omprakash ARYA. "Comparative Foliar Epidermal Studies in Coix lacryma-jobi L. andCoix aquatica Roxb. (Poaceae)." Notulae Scientia Biologicae 1, no. 1 (2009): 37–40. http://dx.doi.org/10.15835/nsb113449.

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As micromorphological knowledge was not available for Coix aquatica Roxb., the foliar epidermal studies were carried out for Coix lacryma-jobi L. and Coix aquatica Roxb. with the aim of determining the patterns of variation in their epidermal characteristics and assessing their value in species identification. Comparative foliar analysis was carried out by using light microscopy, after following routine scraping method. The characters of diagnostic importance in the identification of C. aquatica are the sparsely distributed prickle hairs with long pointed apex in the abaxial epidermis and dumb

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du Cros, D. L., K. Isaacs, and G. P. Moore. "Distribution of acidic and basic fibroblast growth factors in ovine skin during follicle morphogenesis." Journal of Cell Science 105, no. 3 (1993): 667–74. http://dx.doi.org/10.1242/jcs.105.3.667.

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Acidic and basic fibroblast growth factors (aFGF and bFGF) have been localized by immunochemistry in ovine skin during wool follicle morphogenesis. At 40 days of gestation, prior to the appearance of follicle primordia, bFGF immunoreactivity was detected in the intermediate and periderm layers of the epidermis and at the dermal-epidermal junction. Antibodies to aFGF did not bind to skin at this age. During early follicle formation, at 76 days of gestation, both FGFs were found in the epidermis and associated with the follicle primordia. Antibodies to aFGF, in particular, bound to the basal cel

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Lewis, Natasha Steffi, Geetika Chouhan, Vivek Belapurkar, et al. "A new tension induction paradigm unravels tissue response and the importance of E-cadherin in the developing epidermis." International Journal of Developmental Biology 64, no. 4-5-6 (2020): 343–52. http://dx.doi.org/10.1387/ijdb.190219ms.

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The epidermis, being the outermost epithelial layer in metazoans, experiences multiple external and self-generated mechanical stimuli. The tissue-scale response to these mechanical stresses has been actively studied in the adult stratified epidermis. However, the response of the developing bi-layered epidermis to differential tension and its molecular regulation has remained poorly characterised. Here we report an oil injection based method, which in combination with atomic force microscopy (AFM), allows manipulation as well as estimation of tension in the developing epidermis. Our results sho

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Hua, Xiangmei, Maria K. Ficaro, Nicole L. Wallace та Jun Dai. "Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism". International Journal of Molecular Sciences 25, № 19 (2024): 10698. http://dx.doi.org/10.3390/ijms251910698.

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The skin epidermis provides a barrier that is imperative for preventing transepidermal water loss (TEWL) and protecting against environmental stimuli. The underlying molecular mechanisms for regulating barrier functions and sustaining its integrity remain unclear. RORα is a nuclear receptor highly expressed in the epidermis of normal skin. Clinical studies showed that the epidermal RORα expression is significantly reduced in the lesions of multiple inflammatory skin diseases. In this study, we investigate the central roles of RORα in stabilizing skin barrier function using mice with an epiderm

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Ogawa, Youichi, Manao Kinoshita, Shinji Shimada, and Tatsuyoshi Kawamura. "Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis." Journal of Immunology Research 2018 (December 9, 2018): 1–11. http://dx.doi.org/10.1155/2018/5404093.

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In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli. Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis. Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation. The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs). The presence of zinc in the epidermis promotes epidermal homeostasis; hence

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Matsui, Takeshi. "Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells." Journal of Developmental Biology 11, no. 4 (2023): 43. http://dx.doi.org/10.3390/jdb11040043.

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Epidermal development is responsible for the formation of the outermost layer of the skin, the epidermis. The establishment of the epidermal barrier is a critical aspect of mammalian development. Proper formation of the epidermis, which is composed of stratified squamous epithelial cells, is essential for the survival of terrestrial vertebrates because it acts as a crucial protective barrier against external threats such as pathogens, toxins, and physical trauma. In mammals, epidermal development begins from the embryonic surface ectoderm, which gives rise to the basal layer of the epidermis.

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Mills, Kevin J., Michael Doyle, John S. House та ін. "Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function". PLOS One 20, № 6 (2025): e0326670. https://doi.org/10.1371/journal.pone.0326670.

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CCAAT/enhancer binding protein-β (C/EBPβ) is a basic leucine zipper transcription factor that is abundantly expressed in epidermal keratinocytes of skin. In the present study, C/EBPβ epidermal specific conditional knockout (CKOβ) SKH1 mice were utilized to interrogate C/EBPβ’s role in lipid biosynthesis and skin barrier integrity. RNAseq data analysis and gene set enrichment analysis of RNA isolated from the epidermis of CKOβ and K5Cre control mice revealed that deletion of C/EBPβ in epidermis resulted in an enrichment of downregulated genes in gene sets associated with lipid metabolism. Furth

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Stoler, A., R. Kopan, M. Duvic, and E. Fuchs. "Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation." Journal of Cell Biology 107, no. 2 (1988): 427–46. http://dx.doi.org/10.1083/jcb.107.2.427.

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We report here the isolation and characterization of three antisera, each of which is specific for a single keratin from one of the three different pairs (K1/K10, K14/K5, K16/K6) that are differentially expressed in normal human epidermis and in epidermal diseases of hyperproliferation. We have used these antisera in conjunction with monospecific cRNA probes for epidermal keratin mRNAs to investigate pathways of differentiation in human epidermis and epidermal diseases in vivo and in epidermal cells cultured from normal skin and from squamous cell carcinomas in vitro. Specifically, our results

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Dissertations / Theses on the topic "Epidermis"

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Fear, Mark William. "Wnt signalling in normal adult epidermis and epidermal tumours." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406139.

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Akinduro, Olufolake A. E. "Autophagy in epidermis." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8703.

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Organ‐transplant recipients (OTRs) on a new class of immunosuppressants, rapamycin and its analogues, have reduced cutaneous Squamous Cell Carcinomas (cSCCs). Rapamycin, an mTORC1 inhibitor, is also a known autophagy inducer in experimental models. Autophagy, which literally means self‐eating, is a cell survival mechanism but can also lead to cell death. Therefore, the main hypothesis behind this work is that rapamycin prevents epidermal tumourigenesis by either affecting epidermal mTOR regulation of autophagy and/or selectively affecting epidermal AKT isoform activity. Epidermal keratinocytes

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O'Shaughnessy, Ryan Francis Lucas. "Analysis of gene expression in normal and neoplastic keratinocytes." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325883.

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Gdula, Michal R. "Establishing tissue-specific chromatin organization during development of the epidermis. Nuclear architecture of different layers of murine epidermis and the role of p63 and Satb1 in establishing tissue-specific organization of the epidermal differentiation complex locus." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5382.

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During development, multipotent stem cells establish tissue-specific programmes of gene expression that underlie a process of differentiation into specialized cell types. It was shown in the study that changes in the nuclear architecture during terminal keratinocyte differentiation show correlation with the dynamics of the transcriptional and metabolic activity. In particular, terminal differentiation is accompanied by the decrease of nuclear volume, elongation of its shape, reduction of the number and fusion of nucleoli, increase in the number of centromeric clusters and a dramatic de

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Löwenau, Lilian Julia [Verfasser]. "Human epidermis reconstructed from UV-B irradiated keratinocytes mimics epidermal ageing / Lilian Julia Löwenau." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1121588123/34.

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Ledesma, Jenilyn A. "A stereological and AgNOR analysis of the epidermis and naevi of Chinese." Thesis, Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18656547.

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Gdula, Michal Ryszard. "Establishing tissue-specific chromatin organization during development of the epidermis : nuclear architecture of different layers of murine epidermis and the role of p63 and Satb1 in establishing tissue-specific organization of the epidermal differentiation complex locus." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5382.

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During development, multipotent stem cells establish tissue-specific programmes of gene expression that underlie a process of differentiation into specialized cell types. It was shown in the study that changes in the nuclear architecture during terminal keratinocyte differentiation show correlation with the dynamics of the transcriptional and metabolic activity. In particular, terminal differentiation is accompanied by the decrease of nuclear volume, elongation of its shape, reduction of the number and fusion of nucleoli, increase in the number of centromeric clusters and a dramatic decrease o

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Raj, N. "Mechanistic studies on the human epidermis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1531697/.

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This thesis is an effort to study the concepts of skin barrier function in relation to skin physiology and biochemistry. The study focused on anatomical differences, effects of photoaging, the sensitivity of skin and pigmentation differences. The most photoexposed area of the skin is the face, so the study was designed to evaluate the factors responsible for barrier function in the facial stratum corneum. Firstly, stratum corneum (SC) protein estimated using a colorimetric assay was compared to the non-destructive Squamescan® method. The study found a good correlation between the two methods f

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Easty, David Julia. "A study of the biochemistry and immunochemistry of differentiation of the normal epidermis and involved psoriatic epidermis." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47044.

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Harper, Erin Gail. "Adhesion to laminin 5 suppresses p38 map kinase and activating transcription factor 3 in leading keratinocytes of epidermal wounds /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9299.

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Books on the topic "Epidermis"

1

Triana, Victor Hugo. Epidermis de mar. s.n., 1986.

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Triana, Víctor Hugo. Epidermis de mar. Comunicando Editores, 1986.

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Triana, Victor Hugo. Epidermis de mar. Comunicando, 1986.

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H, Mehregan Amir, ed. Tumors of the epidermis. Butterworths, 1990.

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Agorastos, Theodoros. Fetale Epidermis und Vernix caseosa. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74260-6.

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Maya, Lucía. Lucia Maya: Epidermis del sueño. Museo de Arte de Ponce, 2004.

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Keith, Binnington, and Retnakaran Arthur 1934-, eds. Physiology of the insect epidermis. CSIRO, Australia, 1991.

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T, Rovee David, and Maibach Howard I, eds. The epidermis in wound healing. CRC Press, 2004.

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9

Glazer, Mordechai. Leʼut ba-epidermis ha-akhul: Shirim. Alef, 1989.

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Glazer, Mordechai. Leʾut ba-epidermis ha-akhul: Shirim. Alef, 1989.

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Book chapters on the topic "Epidermis"

1

Suarez, Maria J. "Epidermis." In Encyclopedia of Ophthalmology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35951-4_895-1.

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Montagna, William, Albert M. Kligman, and Kay S. Carlisle. "Epidermis." In Atlas of Normal Human Skin. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4613-9202-6_3.

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Pavelka, Margit, and Jürgen Roth. "Epidermis." In Functional Ultrastructure. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-99390-3_124.

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Whitear, Mary. "Epidermis." In Biology of the Integument. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-00989-5_2.

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Fox, Harold. "Epidermis." In Biology of the Integument. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-662-00989-5_5.

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Suarez, Maria J. "Epidermis." In Encyclopedia of Ophthalmology. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-540-69000-9_895.

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Campos-Ortega, José A., and Volker Hartenstein. "Epidermis." In The Embryonic Development of Drosophila melanogaster. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-22489-2_8.

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Dunford, James C., Louis A. Somma, David Serrano, et al. "Epidermis." In Encyclopedia of Entomology. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_3633.

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Parkinson, E. Kenneth, and W. Andrew Yeudall. "Epidermis." In Human Cancer in Primary Culture, A Handbook. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3304-3_8.

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Gooch, Jan W. "Epidermis." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13687.

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Conference papers on the topic "Epidermis"

1

Chang, Herng-Hua, Yu-Xuan Chou, Chi-Chao Chao, and Sung-Tsang Hsieh. "Automatic Epidermis Segmentation in Fluorescence Images Based on a U-Shaped Network Model." In 2024 International Joint Conference on Neural Networks (IJCNN). IEEE, 2024. http://dx.doi.org/10.1109/ijcnn60899.2024.10650305.

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Gökcan, M. Taha, Yasemin Topuz, and Songül Varlı. "Epidermis Segmentation in Melanoma Whole Slide Images: A Comparative Analysis of Deep Learning Architectures." In 2024 International Conference on INnovations in Intelligent SysTems and Applications (INISTA). IEEE, 2024. http://dx.doi.org/10.1109/inista62901.2024.10683839.

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Viator, John A., Guillermo Aguilar, Steven L. Jacques, and J. Stuart Nelson. "Optimization of Cryogen Spray Cooling for Port Wine Stain Laser Therapy Using Photoacoustic Measurement of Epidermal Melanin." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43169.

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Treatment of vascular skin lesions, such as port wine stain (PWS) birthmarks, uses laser energy to thermally damage the hypervascular regions in the dermis. Delivery of sufficient laser energy to the dermis can be confounded by the more superficial epidermal melanin layer, a broadband optical absorber. Laser pulses directed at skin lesions may result in excessive heating and scarring of the epidermis, resulting also in limiting the energy available to treat the dermal lesion. Cryogen spray cooling is used to selectively cool the epidermis, allowing the use of higher laser fluences which cause

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Viator, John S., Steven L. Jacques, and Guillermo Aguilar. "Imaging of Port Wine Stain Lesions Using a Multi-Sensor Photoacoustic Probe." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-60872.

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Successful treatment of port wine stain (PWS) birthmarks in human skin utilizes cryogen spray cooling (CSC) in conjunction with laser treatment. CSC pre-cools the epidermis to protect it from subsequent laser irradiation which raises the temperature of both the epidermis and the deeper PWS. As the epidermal temperature is depressed by cryogen, damage to the skin surface is minimized while the PWS reaches temperatures sufficient to permanently damage the lesion. In order to optimize cooling and laser heating dosages and to properly guide laser therapy, the spatial relationship of epidermal mela

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hayder ALMEHANYA, Farqad, and Azhar Abdulameer SOSA. "ANATOMICAL STUDY OF THE EPIDERMIS LEAVES FOR SOME GENUS OF ASTERACEAE IN DIWANIYAH." In VI.International Scientific Congress of Pure,Applied and Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress6-37.

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The current research includes anatomical study of epidermis of some genera that belong to the sunflower family Asteraceae (Compositae), which are Aster L., Calendula L., Dendranthema L., Helianthus L., Lactuca L., Launaea L. and Tagetes L.. And it was found that the anatomical characteristics have the importance of classification in the isolation of genera. The characteristic of undulation of the epidermal anticlincal cell walls of leaves was of great importance in isolation, and the study also showed some importance indumentum such as isolating Dendranthema L. from the rest of the genus becau

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Utz, Sergei R., Alexander B. Pravdin, Vyacheslav I. Kochubey, Ilya V. Yaroslavsky, Svetlana P. Chernova, and Valery V. Tuchin. "Optical testing of human epidermis." In International Symposium on Biomedical Optics Europe '94, edited by Sigrid Avrillier, Britton Chance, Gerhard J. Mueller, Alexander V. Priezzhev, and Valery V. Tuchin. SPIE, 1995. http://dx.doi.org/10.1117/12.200838.

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Utz, Sergei R. "Exfoliative karyometry of the epidermis." In Volga Laser Tour '93, edited by Valery V. Tuchin. SPIE, 1994. http://dx.doi.org/10.1117/12.179004.

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Alexander, Frank A., and Joachim Wiest. "Automated transepithelial electrical resistance measurements of the EpiDerm reconstructed human epidermis model." In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2016. http://dx.doi.org/10.1109/embc.2016.7590741.

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Geerligs, Marion, Lambert C. A. v. Breemen, Gerrit W. M. Peters, Paul A. J. Ackermans, Cees W. J. Oomens, and Frank P. T. Baaijens. "Mechanical Properties of the Epidermis and Stratum Corneum Determined by Submicron Indentation In Vitro." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204412.

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The outer skin layers are important drug and vaccine delivery targets in the treatment of diseases. These skin layers possess some important characteristics making them favorable sites for pain-free delivery with minimal damage: a rich population of immunologically sensitive cells as well as the lack of blood vessels and sensory nerve endings [1]. Until today, however, the development of effective cell targeting methods is acquainted with many challenges. A collective shortcoming is a poor understanding of the key mechanical properties of the outer skin layers, e.g. the stratum corneum and epi

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Aguilar, Guillermo, Sergio H. Diaz Valdes, J. Stuart Nelson, and Enrique J. Lavernia. "Effect of Time-Dependent Boundary Conditions on Epidermal Tissue Damage During Port Wine Stain Laser Surgery." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/htd-24419.

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Abstract Port wine stain (PWS) birthmarks are a congenital and progressive vascular malformation of the dermis, involving capillaries, which occurs in approximately 0.7% of children. The objective of laser surgery for this and similar conditions is to cause selective thermal damage, thrombosis, and, eventually, permanent photocoagulation in the PWS vessels. To achieve this, the radiated laser light is set at a specific wavelength, which is highly absorbed by the blood vessels’ hemoglobin (the major chromophore in blood). Unfortunately, the PWS vessels do not absorb all energy radiated — a sign

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Reports on the topic "Epidermis"

1

Philip W. Becraft. Analysis of a signal transduction pathway involved in leaf epidermis differentiation. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/840253.

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Pell, Eva J., Sarah M. Assmann, Amnon Schwartz, and Hava Steinberger. Ozone Altered Stomatal/Guard Cell Function: Whole Plant and Single Cell Analysis. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7573082.bard.

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Original objectives (revisions from original proposal are highlighted) 1. Elucidate the direct effects O3 and H2O2 on guard cell function, utilizing assays of stomatal response in isolated epidermal peels and whole cell gas exchange. 2. Determine the mechanistic basis of O3 and H2O2 effects on the plasma membrane through application of the electrophysiological technique of patch clamping to isolated guard cells. 3. Determine the relative sensitivity of Israeli cultivars of economically important crops to O3 and determine whether differential leaf conductance responses to O3 can explain relativ

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Durán, Laura D., Julián Ossa, Ana M. Caicedo, and Arturo Carabali Muñoz. Métodos de aplicación de nematodos entomopatógenos para control de Compsus viridivittatus Guérin-Méneville (Coleoptera: Curculionidae). Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA, 2016. http://dx.doi.org/10.21930/agrosavia.poster.2016.10.

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El picudo C. viridivittatus se consideró uno de los principales limitantes fitosanitarios del cultivo de cítricos en regiones productoras de Colombia, se considera una plaga de doble acción, ya que la larva causa daño en raíces y el adulto en hojas. El estado de larva es el más dañino, éstas caen al suelo y se entierran rápidamente para proceder a su alimentación, inicialmente lo hacen de raicillas y pelos absorbentes para después alimentarse de raíces más gruesas consumiendo la epidermis y cortezas de las raíces secundarias y de la raíz pivotante. Los daños causados por los estados larvarios

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Savaldi-Goldstein, Sigal, and Todd C. Mockler. Precise Mapping of Growth Hormone Effects by Cell-Specific Gene Activation Response. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699849.bard.

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Plant yield largely depends on a complex interplay and feedback mechanisms of distinct hormonal pathways. Over the past decade great progress has been made in elucidating the global molecular mechanisms by which each hormone is produced and perceived. However, our knowledge of how interactions between hormonal pathways are spatially and temporally regulated remains rudimentary. For example, we have demonstrated that although the BR receptor BRI1 is widely expressed, the perception of BRs in epidermal cells is sufficient to control whole-organ growth. Supported by additional recent works, it is

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Herlyn, Dorothee M. Targeting Mutated Epidermal Growth Factor Receptor. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada371205.

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Schwartz, Pauline M. An Epidermal Biosensor for Carcinoembryonic Antigen. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada413966.

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บุญรัตนกรกิจ, วิโรจน์. ตัวจับของโปรเจสเตอโรนหยุดยั้งการเติบโตของเซลล์มะเร็งปอดโดยการรบกวนการส่งสัญญาณของ Epidermal growth factor receptor (EGFR). จุฬาลงกรณ์มหาวิทยาลัย, 2016. https://doi.org/10.58837/chula.res.2016.42.

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ในปัจจุบันเริ่มมีหลักฐานว่า progesterone receptor (PR) มีความเกี่ยวข้องกับมะเร็งปอดชนิด NSCLC อย่างไรก็ตามยังไม่มีการศึกษาเกี่ยวกับกลไกการส่งสัญญาณของ PR กับ NSCLC โดยจากการศึกษาที่ผ่านมาพบว่า PR มี Polyproline SH3 recognition motif (PXXPXR motif หรือ PPD) ที่สามารถจับกับ SH3 domain ของ signaling molecules ได้ ผู้วิจัยจึงตั้งสมมุติฐานว่า PXXPXR motif ของ PR สามารถขัดขวางการส่งสัญญาณของ EGFR ผ่าน MAPK และ/หรือ AKT pathway ในเซลล์มะเร็งปอดได้ ซึ่งจะส่งผลให้เซลล์มะเร็งปอดมีการเจริญเติบโตลดน้อยลง โดยทำการทดสอบบทบาทของ PXXPXR motif ในด้านการเจริญเติบโตและการส่งสัญญาณในเซลล์มะเร็งปอดที่มีการแสดงออกข

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Adamson, Eileen D. Epidermal Growth Factor-Like Ligands in Breast Cancer. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada366955.

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Adamson, Eileen D. Epidermal Growth Factor-Like Ligands in Breast Cancer. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada300591.

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Liedtke, Wolfgang. Role of Ca++ Influx via Epidermal TRP Ion Channels. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada620001.

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