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Dissertations / Theses on the topic 'Epidermoid Lewis lung carcinoma'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Yan, Dejun. "THE EFFECT OF CURCUMIN ON LEWIS LUNG CARCINOMA." Bowling Green State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1308588440.

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2

Nahreini, Piruz. "Regulation of Lewis lung carcinoma cell growth by prostaglandins." Virtual Press, 1985. http://liblink.bsu.edu/uhtbin/catkey/424559.

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A cloned metastatic variant of a murine tumor cell line, Lewis lung carcinoma (LLC(C3), was synchronized by double exposure to thymidine (5 x 10-4 M) at G1/S boundary. The effects of Prostaglandin (PG)E1, PGE2, PG synthetase inhibitors, and an analog of cAMP (dbut-cANP) on the life cycle of synchronized LLC(C3) cells were examined. When added to cells in G1 phase, PGE1 and dbut-cAMP enhanced 3H-thymidine uptake during S phase. Both of these agents suppressed S phase when they were added to cells entering S phase. The addition of PGE2 to LLC(C3) cells in G1 phase had no effect on S phase of the

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3

Wheeler, Elizabeth H. "Natural killer cell activity in mice bearing Lewis lung carcinoma." Virtual Press, 1985. http://liblink.bsu.edu/uhtbin/catkey/416656.

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Natural killer (NK) cells are important in limiting tumor dissemination. The NK activity in C57B1/6 mice bearing Lewis lung carcinoma (LLC) was monitored during tumor development. During the initial period of tumor growth, NK activity was enhanced. As tumor growth progressed, NK activity became suppressed. Depletion of macrophages from the spleen cells of tumor-bearing mice restored the NK cytotoxic response. Plasma prostaglandin E2 (PGE2) concentrations were measured by a radioimmunoassay and found to become elevated during the course of tumor growth. To determine whether the suppressed NK ac

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4

Endicott, Roger A. "Immunoregulation of T-lymphocyte proliferative activity by alveolar macrophages from mice bearing Lewis lung carcinoma tumors." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/458971.

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The immune regulatory abilities of alveolar macrophages from C57B1/6 mice bearing a metastatic variant of Lewis lung carcinoma were determined. During early stages of tumor development, or before tumors metastasized to the lungs, alveolar macrophages did not affect or slightly enhanced T-lymphocyte proliferation; as tumor growth progressed, or following tumor metastasis, alveolar macrophages suppressed the T-cell response. Macrophage suppressor activity was probably not mediated by their production of PGE, since macrophages of tumor-bearing mice secreted less 2 PGE than did macrophages of norm

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5

Shestowsky, William S. "Production and characterization of a monoclonal antibody to a highly metastatic and organ-selective variant of the Lewis lung carcinoma." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61747.

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6

Duffie, Gordon Patrick. "Tumoricidal activity of pulmonary alveolar macrophages isolated from C57BL/6 mice bearing either a cloned metastatic or nonmetastatic variant of Lewis lung carcinoma." Virtual Press, 1988. http://liblink.bsu.edu/uhtbin/catkey/558376.

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The spontaneous tumoricidal ability of pulmonary alveolar macrophages (PAM) isolated from C57B1/6 mice bearing either a metastatic or a nonmetastatic cloned variant of Lewis lung carcinoma (LLC) was examined in vitro. During the early weeks of tumor development the cytotoxicity mediated by macrophages was enhanced in the tumor-bearing mice, especially in the metastatic tumor bearers. Later in tumor progress (week 4) the spontaneous cytotoxicity of both groups typically declined to levels less than those of normal macrophages. Experiments were performed to determine if macrophages could be acti

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7

Moraes, Adriel dos Santos 1976. "Administração de nanotubos de carbono "multiwalled" in vivo ativa citotoxicidade tumor-específica de linfócitos T CD8+." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/259942.

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Orientador: Vitor Baranauskas<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Elétrica e de Computação<br>Made available in DSpace on 2018-08-20T09:27:39Z (GMT). No. of bitstreams: 1 Moraes_AdrieldosSantos_M.pdf: 1300108 bytes, checksum: bcd1099ef486cc4a2842627fe2b4df57 (MD5) Previous issue date: 2012<br>Resumo: A administração "in vivo" de nanotubos de carbono "multi-walled" (MWCNT's), mesmo sem serem funcionalizados, estimula o aparecimento de uma reposta imune em camundongos normais. Nesse trabalho nós fornecemos evidências de que essas nanopartícula

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8

Gallot, Yann. "Invalidation du gène de la myostatine dans un modèle murin de cachexie associée au cancer : implication dans la régulation de la masse musculaire." Phd thesis, Université Jean Monnet - Saint-Etienne, 2013. http://tel.archives-ouvertes.fr/tel-01058905.

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La cachexie est un syndrome clinique et métabolique caractérisé par une perte de tissu adipeux et de tissu musculaire, fréquemment observé chez les patients atteints de cancer. La myostatine (Mstn) régule négativement la masse musculaire. Bien que la régulation des mécanismes moléculaires impliqués dans le contrôle de la masse musculaire joue un rôle central dans la cachexie associée au cancer, les relations existant entre la Mstn et les mécanismes physiopathologiques restent largement inconnues. Suite à l'inoculation de cellules Lewis lung carcinoma (LLC) à des souris, nous avons montré que l

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9

Puka, Juliana. "Perfil biomolecular do derrame pleural maligno experimentalmente induzido: frequência de mutações e impacto de terapias-alvo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-06022017-154634/.

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INTRODUÇÃO: O câncer de pulmão é a principal causa de morte por câncer em todo o mundo e muitos pacientes apresentam derrame pleural em um estágio avançado da doença, com alta morbidade e mortalidade. Entretanto, a patogênese do derrame maligno é ainda pouco compreendida e as opções terapêuticas são limitadas. OBJETIVO: 1) Estudar a fisiopatologia do derrame pleural maligno em modelo animal com células de Lewis em diferentes concentrações; 2) Avaliar os efeitos da terapia intrapleural com anti-VEGF e anti-EGFR e a frequência de mutações de EGFR e KRAS neste modelo. MÉTODOS: Foi utilizado model

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10

Akramienė, Dalia. "Assessment of the modulation of photodynamic effect by β-glucan and characteristics of anti-CD7 monoclonal antibody during tumor process". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110309_111259-65000.

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Activation of the immune system during photodynamic therapy (PDT) and improvement of the effector functions of mAbs - these are the ways to use and enhance the potential of the immune system to fight cancer. Tumor cells lack β-glucan as a surface compo¬nent and can‘t trigger complement receptor 3-dependent cellular cytoto¬xicity and initiate tumor-killing activity during PDT. So, it gave rise to the hypothesis that β-glucan in combination with PDT will produce more effective killing of by iC3b fragment opsonized tumor cells. The human Fc portion is essential for the recruiting of human effecto

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11

Chen, Chin Yang, and 陳勁揚. "Efficacy of Parabacteroides goldsteinii ameliorates Lewis lung carcinoma." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107CGU05604004%22.&searchmode=basic.

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12

Chen, Miao Pei, and 陳妙佩. "Vasostatin induced apoptosis in endothelial cells and inhibited Lewis lung carcinoma in mice." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/98978871841349041320.

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碩士<br>高雄醫學大學<br>醫學研究所<br>89<br>Abstract Anti-angiogenesis strategy has been actively investigated for cancer treatment in recent years. One the latest identified angiogenesis inhibitors, vasostatin, was isolated from conditioned media of EBV-immortalized cells and identified as NH2-terminal fragment (amino acids 1-180) of a calcium-binding protein calreticulin. In this study, we have cloned vasostatin cDNA from lymphoma cells by RT-PCR. After verification by DNA sequencing, vasostatin cDNA was subcloned into E.coli expression vector to express and generate large quantities of recomb

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13

Liu, Yi-Zhen, та 劉懿真. "α-Carotene inhibits metastasis of Lewis lung carcinoma both in vitro and in vivo". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/fce779.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>101<br>α-Carotene, one of the major carotenoids in human plasma, can be found in yellow-orange and dark-green fruits and vegetables, such as carrots, spinach, pumpkin and tomatoes. Epidemiological studies have indicated that higher serum levels of α-carotene are associated with lower risk of chronic diseases, including cancer. Our previous studies have demonstrated that α-carotene exhibits anti-metastatic activity in human hepatocarcinoma SK-Hep-1 cells. However, it is unclear whether α-carotene has similar effects in lung cancer, the major leading cause of d

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14

Jhou, Ren-Shiang, and 周仁祥. "The antitumor immunity of FasL-transfected Lewis lung carcinoma enhanced by cyclooxygenase-2 inhibitor." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/33719154880866707166.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>92<br>Abstrsct The Fas ligand (FasL) induces programmed cell death via interaction with its receptor Fas. It has been proposed that expression of FasL can confer immune privilege to some organs, allowing them to kill infiltrating lymphocytes and inflammatory cells. However, a number of studies have shown that when tumors express FasL that can recruit neutrophils to induce inflammation. The Lewis lung carcinoma express FasL (FasL-LLC) which can elicit antitumor activity. But the antitumor activity is not good enough that we expected. In this study, C57/BL6J mice we

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15

Chuang, Chin-Nien, and 莊謹年. "Fucoidan Inhibits Lewis Lung Carcinoma Cells Migration via Suppression of VEGF and MMPs Activity." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/34273667710107385371.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>99<br>Fucoidan is a complex sulfated polysaccharide with a wide variety of biological activities including anti-oxidant, anti-tumor, immunomodulatory, anti-complement, blood lipids reducing and anti-virus. The six hallmarks of cancer is grown signal autonomy, evasion of grown inhibitory signals, evasion of apoptosis, unlimited replicative potential, angiogenesis and metastasis. Malignant tumor is the leading cause of high death in the world. In fact, metastasis is the major cause of death. However, the effects of fucoidan in anti-migration of tumor cells have not bee

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16

伍婉琳. "Genetic immunotherapy of eatablished lewis lung carcinoma with fasl expressed by tetracycline-regulated retroviral vector." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/86023212808527581762.

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17

朱嘉憶. "Induction of antitumor immunity with injection of Fas Ligand (CD95L )-transfected Lewis lung carcinoma in mice." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/54038416689573032353.

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碩士<br>國立海洋大學<br>水產生物技術研究所<br>90<br>The abilities of tumors to escape a functional immune system and persist in growth suggest that host immune mechanisms have failed to recognize and eliminate tumor cells. A variety of gene therapeutic strategies that induce systemic antitumor effects are under investigation, including the transfer of genes of cytokines to tumor cells. The Fas-Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression and stimulation of immune responses. It has been demonstrated that gene transfer of FasL

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18

Li, Shuang-Hua, and 李順華. "Suppression of fibrinolytic activity, cell adhesion, and viability of Lewis Lung Carcinoma cells by nanodot arrays." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/65502029754325378484.

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碩士<br>國立交通大學<br>材料科學與工程學系奈米科技碩博士班<br>99<br>Biomaterials play an important role in bioengineering applications. To evaluate cellular response to a nanoscaled surface, Mouse Lewis Lung Carcinoma (LL/2) cells were cultured onto Nanodot arrays with dot diameters ranging from 10 to 200-nm. The Nanodot arrays were fabricated by anodic aluminum oxide (AAO) processing on TaN-coated wafers. The size-dependent effect of Nanodot arrays on cell growth, corresponding to cell proliferation, cell adhesion, cytoskeletal organization, and gene expression is the main point of our study. Optimized growth occurr

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19

Tsai, Yi-Lin, and 蔡一麟. "Enhancing Antitumor Immunity of FasL-Transfected Lewis Lung Carcinoma Is Used by Dendritic Cell-Based Vaccine." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/38866978641976551875.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>92<br>Abstract The malignant tumor is a serious disease in human today. Conventional treatments for it include surgery, chemotherapy, and radiation therapy used alone or in combination. Despite the increasingly intense application and continuous modification of these approaches，the overall cure rate for malignant tumor remains poor. The treatments mentioned above could not be effective and specific to eradicate tumors in patients. Thus , due to explore new treatment options is paramount, the concepts of gene therapy and immunotherapy of cancer come to existence. R

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20

Jing-FangLin and 林靜芳. "Pterostilbene Inhibits Pulmonary Metastasis viaSuppressing Polymeric Fibronectin Assembly on TheSurface of Blood-borne Lewis Lung Carcinoma Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/62954211308611699079.

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21

Mei-Ying, Chang, and 張美瑩. "Studies on the cytogenotoxicities of nitric oxide donors and anticancer drug-Adriamycin in Lewis lung carcinoma cells." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/94277924637314785628.

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碩士<br>中山醫學院<br>醫學研究所<br>89<br>Nitric oxide (NO) is a ubiquitous, physiologically active molecule involved in many biological functions and diseases. The unique attributes and importance of NO were recently recognized by the Nobel Prize Committee, with their decision to award the 1998 Prize in Medicine to Drs. Furchgott, Ignarro, and Murad. In this study, we attempted to investigate the genotoxic and cytotoxic effects of different nitric oxide donors, sodium nitroprusside (SNP), 3-morpholinosydnonimine (SIN-1), S-nitroso -glutathione (GSNO), and S-nitroso-N-acetyl-DL -penicillamine (SNAP), and

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22

Chan, Ya-Ping, and 詹雅評. "Lycopene in combination with sorafenib inhibits cancer metastasis in mice xenografted with Lewis lung carcinoma cells (LLC)." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/12013639657360914923.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>104<br>Lycopene is one of the major carotenoids in tomatoes. Studies have shown that lycopene possesses functions such as gap junctional communication, anti-proliferation, anti-angiogenesis and anti-metastatic. Sorafenib is the first antitumor agent that has demonstrated and improved overall survival for advenced hepatocellular carcinoma and renal cell carcinoma. Side effects of sorafenib include loss of appetite, diarrhea, hair thinning, nausea or vomiting, hand-foot syndrome, or weight loss. Cancer metastasis is the main cause of death in cancer patients. Seve

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23

Fa, Kuan-Ning, and 法冠寧. "Glycoprotein from mycelia of Antrodia cinnamomea inhibits metastasis of Lewis lung carcinoma 1 cells through direct action and immunomodulation." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/37081379212515147775.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>101<br>Metastasis, a complex and a multi-step process, is the major cause of death in cancer patients. Therefore, inhibition of cancer metastasis is considered one of the therapeutic strategies. Antrodia cinnamomea (AC), also called “zhan-chi” or “niu-chang-ku”, is a unique medicinal fungus in Taiwan. Glycoprotein from mycelia of AC (AC-GP) was previously shown to possess anti-inflammation and antioxidant activity, but it is still unclear whether AC-GP has anti-cancer actions. Herein, we investigated the effect of AC-GP on cancer metastasis in this thesis.

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24

Huang, Hsin-Yao, and 黃馨瑤. "Effect of water extract of Sea Buckthorn Leaves on muscle atrophy in Lewis Lung carcinoma induced mouse cancer cachexia." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/92665894757404473468.

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碩士<br>中山醫學大學<br>營養學研究所<br>102<br>Skeletal muscle wasting is a major symptom of cancer cachexia, which is caused by the degredation of muscle fibers through ubiquitin-proteasome pathway (UPP) and autophagy- lysosome pathway (ALP).The muscle atrophy model of cancer cachexia of mice was induced by the injection of Lewis lung cancer (LLC) cells subcutaneously to the mice. The effects of water extract of Sea Buckthorn leaf (SBT) on reduction of skeletal muscle atrophy were evaluated. We analyzed the marker proteins of UPP and ALP, including Muscle RING finger 1(MuRF1) , Muscle atrophy F-box1(Atrogi

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25

Jhang, Jhung-Huai, and 張中懷. "Effects of Ethanol Extract Derived from Fruit-Body of Antrodia cinnamomea on the Metastasis of Lewis Lung Carcinoma (LLC) in Mice." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/07955435788685909765.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>102<br>In the present study, ethanol extract of fruit body of Antrodia cinnamomea (EEAC) was applied for the investigation using murine model. When the experimental mice treat 8 mg/kg of b.w. level, the primary tumor was significantly suppressed and the concentration of metalloproteinases (MMP)-9 and MMP-2 in serum were also reduced. The results of gelatin zymography assay showed that EEAC at 8 mg/kg of b.w. may suppress the activity of MMP-9 in lung tissue. When the animals were treated with EEAC at 8 or 80 mg/kg of b.w., respectively the clinical prognostic indic

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26

Chen, Man-Ling, and 陳嫚羚. "Effects of lycopene on angiogenesis in vivo and the combination of lycopene with cisplatin on tumor growth and lung metastasis in C57BL/6 mice xenografted with Lewis lung carcinoma." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/c4u7ua.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>100<br>Overall abstract Cancer metastasis is responsible for the cause of treatment failure and deaths in cancer patients. Tumor proliferation and angiogenesis were played an important role in the complex multistep of metastasis process. To reduce the mortality of cancer patients, the blockage of the cancer metastasis cascade is regarded as a powerful strategy in anticancer therapeutics. Recently, phytochemicals such as genistein and curcumin have been reported to exert anticancer effect and may cooperatively or synergistically enhance the effects of anticanc

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27

Chen, Pei-Chun, and 陳佩君. "Antrodan, a glycoprotein isolated from Antrodia cinnamomea mycelia, in combination with cisplatin inhibits tumor metastasis and protects against cisplatin-induced nephrotoxicity in C57BL/6 mice xenografted with Lewis lung carcinoma." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/63308341857956854979.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>103<br>Antrodia cinnamomea is a species known to be a treasured medicinal mushroom in Taiwan. Several studies have indicated that Antrodan, the glycoprotein from Antrodia cinnamomea mycelia, exhibits anti-inflammation and anti-oxidative actions. In addition, Antrodan has been shown to inhibit cancer metastasis in Lewis lung carcinoma (LLC) through direct action and immunomodulation. However, it is still unclear whether Antrodan has anti-metastatic effects in vivo. This study aimed to investigate the anti-metastatic effects of Antrodan and Antrodan in combination

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28

Su, Cheng-Ming, and 蘇建名. "Inhibitory effect of vitamin C plus vitamin K3 on tumor growth and metastasis of Lewis lung carcinoma xenografted in C57BL/6 mice and the protective effect of vitamin C against cisplatin toxicity." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/16423012449796736157.

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碩士<br>國立中興大學<br>食品暨應用生物科技學系所<br>99<br>Overall abstract: Lung cancer, a highly metastatic cancers and difficultly diagnosis in an early stage, is one of the most common cause of death for cancer patients death in worldwide. Metastasizing cells must first disseminate from the primary tumor, invade the surrounding tissue, intravasate and extravasate the circulatory system, arrest, initiate angiogenesis and colonize distant site. Therefore, development of novel therapeutic strategy for treatment lung cancer is important. Vitamin C in combination with vitamin K3 (vit CK3) has been shown to inhib

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