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Relevant bibliographies by topics / Epigenome editors

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Journal articles

Academic literature on the topic 'Epigenome editors'

Author: Grafiati

Published: 12 April 2025

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Journal articles on the topic "Epigenome editors"

1

Syding, Linn Amanda, Petr Nickl, Petr Kasparek, and Radislav Sedlacek. "CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review." Cells 9, no. 4 (2020): 993. http://dx.doi.org/10.3390/cells9040993.

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Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a great deal of homology in terms of genetic etiologies and symptoms. Disruption of genetic or epigenetic mechanisms can cause issues with regulating the expression of imprinted genes, thus leading to disease. Genetic mutations affect the imprinted genes, duplications, deletions, and uniparental disomy (UPD) are reoccurring phenomena causing imprinting diseases. Epigenetic alterations on methylation marks in imprinting

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2

Nakamura, Muneaki, Alexis E. Ivec, Yuchen Gao, and Lei S. Qi. "Durable CRISPR-Based Epigenetic Silencing." BioDesign Research 2021 (July 1, 2021): 1–8. http://dx.doi.org/10.34133/2021/9815820.

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Development of CRISPR-based epigenome editing tools is important for the study and engineering of biological behavior. Here, we describe the design of a reporter system for quantifying the ability of CRISPR epigenome editors to produce a stable gene repression. We characterize the dynamics of durable gene silencing and reactivation, as well as the induced epigenetic changes of this system. We report the creation of single-protein CRISPR constructs bearing combinations of three epigenetic editing domains, termed KAL, that can stably repress the gene expression. This system should allow for the

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3

Fang, Yongxing, Wladislaw Stroukov, Toni Cathomen, and Claudio Mussolino. "Chimerization Enables Gene Synthesis and Lentiviral Delivery of Customizable TALE-Based Effectors." International Journal of Molecular Sciences 21, no. 3 (2020): 795. http://dx.doi.org/10.3390/ijms21030795.

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Designer effectors based on the DNA binding domain (DBD) of Xanthomonas transcription activator-like effectors (TALEs) are powerful sequence-specific tools with an excellent reputation for their specificity in editing the genome, transcriptome, and more recently the epigenome in multiple cellular systems. However, the repetitive structure of the TALE arrays composing the DBD impedes their generation as gene synthesis product and prevents the delivery of TALE-based genes using lentiviral vectors (LVs), a widely used system for human gene therapy. To overcome these limitations, we aimed at chime

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4

Roman Azcona, Maria Silvia, Yongxing Fang, Antonio Carusillo, Toni Cathomen, and Claudio Mussolino. "A versatile reporter system for multiplexed screening of effective epigenome editors." Nature Protocols 15, no. 10 (2020): 3410–40. http://dx.doi.org/10.1038/s41596-020-0380-y.

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5

Willyard, Cassandra. "The epigenome editors: How tools such as CRISPR offer new details about epigenetics." Nature Medicine 23, no. 8 (2017): 900–903. http://dx.doi.org/10.1038/nm0817-900.

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6

O’Geen, Henriette, Marketa Tomkova, Jacquelyn A. Combs, Emma K. Tilley, and David J. Segal. "Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing." Nucleic Acids Research 50, no. 6 (2022): 3239–53. http://dx.doi.org/10.1093/nar/gkac123.

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Abstract Precision epigenome editing has gained significant attention as a method to modulate gene expression without altering genetic information. However, a major limiting factor has been that the gene expression changes are often transient, unlike the life-long epigenetic changes that occur frequently in nature. Here, we systematically interrogate the ability of CRISPR/dCas9-based epigenome editors (Epi-dCas9) to engineer persistent epigenetic silencing. We elucidated cis regulatory features that contribute to the differential stability of epigenetic reprogramming, such as the active transc

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7

Psatha, Nikoletta, Kiriaki Paschoudi, Anastasia Papadopoulou, and Evangelia Yannaki. "In Vivo Hematopoietic Stem Cell Genome Editing: Perspectives and Limitations." Genes 13, no. 12 (2022): 2222. http://dx.doi.org/10.3390/genes13122222.

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The tremendous evolution of genome-editing tools in the last two decades has provided innovative and effective approaches for gene therapy of congenital and acquired diseases. Zinc-finger nucleases (ZFNs), transcription activator- like effector nucleases (TALENs) and CRISPR-Cas9 have been already applied by ex vivo hematopoietic stem cell (HSC) gene therapy in genetic diseases (i.e., Hemoglobinopathies, Fanconi anemia and hereditary Immunodeficiencies) as well as infectious diseases (i.e., HIV), and the recent development of CRISPR-Cas9-based systems using base and prime editors as well as epi

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8

Dehshahri, Ali, Alessio Biagioni, Hadi Bayat, et al. "Editing SOX Genes by CRISPR-Cas: Current Insights and Future Perspectives." International Journal of Molecular Sciences 22, no. 21 (2021): 11321. http://dx.doi.org/10.3390/ijms222111321.

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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a substantial revolution has arisen in the genome engineering field. In recent years, CRISPR-Cas technology was rapidly developed and different types of DNA or RNA sequence editors, gene activator or repressor, and epigenome modulators established. The versatility and feasibility of CRISPR-Cas technology has introduced this system as the most suitable tool for discovering and stud

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9

Szyf, Moshe. "The Epigenome: Molecular Hide and Seek. Stephan Beck and Alexander Olek, editors. Weinheim, Germany: Wiley-VCH GmbH Co. KGaA, 2003, 188 pp., $35.00, softcover. ISBN 3-527-30494-0." Clinical Chemistry 49, no. 9 (2003): 1566–67. http://dx.doi.org/10.1373/49.9.1566.

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10

Brane, Andrew, Madeline Sutko, and Trygve O. Tollefsbol. "p21 Promoter Methylation Is Vital for the Anticancer Activity of Withaferin A." International Journal of Molecular Sciences 26, no. 3 (2025): 1210. https://doi.org/10.3390/ijms26031210.

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Breast cancer (BC) is a widespread malignancy that affects the lives of millions of women each year, and its resulting financial and healthcare hardships cannot be overstated. These issues, in combination with side effects and obstacles associated with the current standard of care, generate considerable interest in new potential targets for treatment as well as means for BC prevention. One potential preventive compound is Withaferin A (WFA), a traditional medicinal compound found in winter cherries. WFA has shown promise as an anticancer agent and is thought to act primarily through its effect

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