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Dissertations / Theses on the topic 'Epigentic control'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lezcano, Magda. "The Control of the Epigenome." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7190.

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The genetic information required for the existence of a living cell of any kind is encoded in the sequence information scripted in the double helix DNA. A modern trend in biology struggles to come to grip with the amazing fact that there are so many different cell types in our body and that they are directed from the same genomic blueprint. It is clear, that the key to this feature is provided by epigenetic information that dictates how, where and when genes should be expressed. Epigenetic states “dress up” the genome by packaging it in chromatin conformations that differentially regulate acce

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2

Sima, Teruel Núria. "Paper de SirT2 en el control epigenètic de la mitosi." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/386527.

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La cromatina és una estructura nucleoproteica, dinàmica i jeràrquicament organitzada dins del nucli cel•Iular. La seva estructura, organització i funció està controlada al llarg del cicle cel.lular, per processos epigenètics que produeixen canvis heretables que no afecten la seqüència de DNA. Entre aquests canvis es troben la metilació del DNA, les modificacions postraduccionals de les histones i desplegament de la cromatina orquestrat pels complexes remodeladors i proteïnes estructurals. Les modificacions postraduccionals de les histones es donen principalment de forma dinàmica i regulada a

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3

Sessa, Luca. "Epigenetic control of human HOX clusters." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402692.

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4

Deraze, Jérôme. "Epigenetic control of ribosome biogenesis homeostasis." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066342/document.

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La traduction est une activité cellulaire essentielle, réalisée par les ribosomes. Ces particules sont synthétisées dans le nucléole, ce qui nécessite l'expression coordonnée de 4 ARN ribosomaux, 80 protéines ribosomales, et plus de 200 facteurs d'assemblage. Leur biogenèse est complexe et sollicite plus de la moitié de l'énergie des cellules en prolifération. La quantité de ribosomes varie selon les conditions environnementales et métaboliques et de ce fait, leur synthèse est modulée en réponse à de nombreux stimuli. Plusieurs mécanismes coordonnent la biogenèse des ribosomes avec l'homéostas

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5

Martucci, Mariane Ferracin. "Impactos das biotécnicas reprodutivas no controle epigenético de genes imprinted." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-20102015-082930/.

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Técnicas de reprodução assistida (TRAs) são utilizadas tanto na medicina humana quanto na medicina veterinária com o objetivo principal de corrigir infertilidades adquiridas ou herdadas. A transferência nuclear de célula somática (TNCS) ocupa um lugar de destaque na veterinária pela possibilidade de geração de indivíduos geneticamente idênticos, permitindo a produção de rebanhos homogêneos de alto mérito genético e servindo como modelo de estudo para técnicas de reprogramação. Porém, a utilização de TRAs, e em especial da TNCS, é considerada responsável pelo aumento na geração de conceptos por

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6

Freyer, Jennifer Sandra Silvia. "Regulation und funktionelle Rolle des murinen Transkriptionsfaktors Foxp3 in T-Zellen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15841.

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In dieser Arbeit wurde die funktionelle Rolle und Regulation des murinen Transkriptionsfaktor Foxp3 untersucht. Der erste wesentliche Teil zur Analyse der funktionellen Rolle war dabei die Erzeugung einer BAC- transgenen Maus. Hierfür wurde ein Zielgenvektor mit der kodierenden Region des eYFPs und einer dualen Selektionskassette sowie die Methode des ET- Klonierens verwendet. Leider war die homologe Rekombination des Zielgenvektors in den BAC nicht erfolgreich. Es kam zu einer ungeklärten Rekombination mit Fremd- DNS. Die Erzeugung der transgenen Maus wurde nach diesem Ergebnis eingestellt, u

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7

Ferreira, Mónica Alexandra dos Santos. "Epigenetic control of the male progenitor germline by the protein phosphatase PP1-NIP." Doctoral thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22814.

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Doutoramento em Biologia<br>NIPP1, for nuclear inhibitor of protein phosphatase 1 (PP1), is a multifunctional scaffold protein that regulates cell signaling, pre-mRNA splicing and transcription by targeting PP1 to specific nuclear substrates. The global deletion of NIPP1 in mice is embryonic lethal at the onset of gastrulation, precluding its functional analysis in adult tissues. This prompted us to generate a tamoxifen-inducible NIPP1 knockout (iKO) mouse model. Unexpectedly, the deletion of NIPP1 was not efficient in the examined organs except for testis. The loss of NIPP1 caused an a

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8

Hitchcock, Robert Arthur. "Epigenetic control of the kinetoplastid spliced leader RNA." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1998392041&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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9

Herranz, Martín Nicolás. "New insights in the epigenetic control of EMT." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/80660.

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The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-‐differentiated epithelial cells to convert to motile mesenchymal cells. EMT is critical for appropriate embryogenesis and plays a crucial role in tumorigenesis and cancer progression. At this regard, it has become increasingly evident that, in addition to genetic alterations, tumour development involves the alteration of gene expression patterns owing to epigenetic changes. Taking this into account, this thesis mainly

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10

Goncharevich, Alexander. "Epigenetic control of Wnt signalling in CNS remyelination." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648183.

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11

Silva, Mariana Coelho Correia da. "Epigenetic and cell cycle control of centromere inheritance." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/10520.

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Dissertation presented to obtain the Ph.D degree in Biology, Cell Biology<br>Cell division is a fundamental process of all living organisms by which a parental cell divides into two genetically identical daughter cells. Faithful cell division requires duplication and subsequent equal distribution of the parental genetic information, the genome, between daughter cells. In eukaryotes, genomic information is organized in chromosomes, which consist of linear DNA sequences packaged into histone protein-DNA complexes called nucleosomes.(...)

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12

Brigham, Mark Daniel. "Optical control of mammalian endogenous transcription and epigenetic states." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11363.

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The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates approaches that enable spatially and temporally precise modulation of gene expression. Recently, a variety of microbial and plant-derived light-sensitive proteins have been engineered as optogenetic actuators, enabling high-precision spatiotemporal control of many cellular functions. However, versatile and robust technologies that enable optical modulation of transcription

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13

Wujak, Lukasz Andrzej [Verfasser]. "Epigenetic control of alveolar fluid clearance / Lukasz Andrzej Wujak." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1069740675/34.

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14

Alkhayer, kholoud. "CHANGES IN HEMOGLOBIN AND EPIGENETIC CONTROL IN MULTIPLE SCLEROSIS." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1564760500990233.

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15

Mariano, Piero. "Epigenetic Regulation and Reprogramming of the H19 Imprinting Control Region." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6299.

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The development of a new individual from the fertilized oocyte can ultimately be seen as the consequence of the establishment and maintenance of specific patterns of gene expression. Although regulation of gene activity occurs at different levels, cellular specialization and differentiation are the results of developmental cues that essentially take place at the transcriptional level. The involvement of epigenetics in this process has become increasingly clear during the last decade. Imprinted genes constitute an excellent example as monoallelic expression seems to reflect differential epigene

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16

Boija, Ann. "Transcriptional and epigenetic control of gene expression in embryo development." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-134354.

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During cell specification, temporal and spatially restricted gene expression programs are set up, forming different cell types and ultimately a multicellular organism. In this thesis, we have studied the molecular mechanisms by which sequence specific transcription factors and coactivators regulate RNA polymerase II (Pol II) transcription to establish specific gene expression programs and what epigenetic patterns that follows. We found that the transcription factor Dorsal is responsible for establishing discrete epigenetic patterns in the presumptive mesoderm, neuroectoderm and dorsal ectoderm

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17

Morez, Constant. "Materials-based strategies for epigenetic control of stem cell fate." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58204.

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Direct reprogramming strategies for cell fate switching hold great promise for regenerative medicine. However, because of the strong stability provided by a cell's epigenome, the efficiency associated with such processes remains critically low. This study shows that the use of microgrooved substrates can dramatically alter a cell's epigenetic landscape. More specifically a significant disruption of the repressive heterochromatin is observed, characterised by a significant diminution of H3K27me3 and H3K9me3 levels and an increase in H3K4me3. In the specific case of cardiac direct programming th

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18

Lee, Bongyong. "Epigenetic Control Mechanisms in Somatic Cells Mediated by DNA Methyltransferase 1." Master's thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6228.

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DNA methylation regulates gene expression through a complex network of protein/protein and protein/DNA interactions in chromatin. The maintenance methylase, DNA methyltransferase 1 (DNMT1), is a prominent enzyme in the process that is linked to DNA replication and drives the heritable nature of epigenetic modifications in somatic cells. The mechanistic details that explain how DNMT1 catalytic action is directed in a chromatin setting are not well understood. We hypothesize that post translational modifications and a variety of protein-protein interactions processes are key regulatory elements

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19

Alkandari, Abdullah. "Epigenetic control of the post-bariatric phenotype : the role of microRNAs." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/55284.

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The rising obesity pandemic and the concomitant rise in its co-morbidities are leading causes of global morbidity and mortality. Bariatric surgery is a form of gastrointestinal surgery that leads to sustained weight loss, diabetes resolution, reduction in cancer risk and other improvements in health. MicroRNAs are a family of small, endogenous, non-coding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs control expression of over half the human transcriptome and are involved in processes fundamental to both normal physiology and disease, including obesity and dia

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20

Jamieson, Kirsty. "Control of Histone H3 Lysine 27 Trimethylation in Neurospora crassa." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/18731.

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Trimethylation of histone H3 lysine 27 (H3K27me3) marks facultative heterochromatin, containing silent genes. My research investigated factors that influence the distribution of H3K27me3 in the filamentous fungus Neurospora crassa. The H3K27 methyltransferase complex, PRC2, is well conserved in eukaryotes and consists of four core members: E(Z), EED, SUZ12 and P55. I showed that three of the PRC2 subunits (SET-7, the homolog of E(Z), EED and SUZ12) are required for H3K27me3 in Neurospora, while NPF, the homolog of P55, is only required for a subset of H3K27me3 domains. H3K27me3 is organize

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21

Oliveira, Dalila Cunha de. "Avaliação do controle da expressão gênica de citocinas pró inflamatórias mediado pela IL-10. Participação da IL-10 na modulação da resposta inflamatória exercida pela glutamina e na restrição alimentar." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9142/tde-16112017-174159/.

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O desenvolvimento de uma resposta imune adequada é um processo extremamente importante para a manutenção da homeostase do organismo. Uma série de processos são desencadeados a partir do primeiro contato com micro-organismos patógenos até a efetivação da resposta imune de memória. Todos esses processos envolvem a participação e a complexa atuação de mediadores como as citocinas inflamatórias e também citocinas regulatórias, que exercerão efeitos controlando o processo inflamatório. Diversos mecanismos moleculares, subjacentes à resposta inflamatória, ainda não estão totalmente compreendidos, co

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22

Detich, Nancy. "Regulation of the DNA methylation machinery and its role in epigenetic control." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19406.

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A growing line of evidence indicates that the proper control of DNA methyltransferases (DNMT) and DNA demethylases is critical for maintaining correct gene expression. In addition, misregulation of this machinery likely plays a role in the aberrant DNA methylation patterns and gene expression that is a hallmark of many pathologies such as cancer. A greater comprehension of the mechanisms involved in regulating the expression and activity of these proteins should provide new therapies aimed at restoring gene expression gone wrong.

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23

Simon, Lauriane. "Organization, variability and epigenetic control of 5S rRNA genes in Arabidopsis thaliana." Thesis, Clermont-Ferrand 2, 2016. http://www.theses.fr/2016CLF22783/document.

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L'ARNr 5S est une partie intégrante du ribosome indispensable pour la synthèse des protéines. Cette fonction essentielle nécessite une régulation fine de l'expression des ARNr 5S en fonction des exigences cellulaires. L'ARNr 5S est codé par des gènes organisés en répétitions en tandem principalement situés dans les régions péricentromériques des chromosomes 3, 4 et 5 dans le génome Col-0 d'Arabidopsis thaliana. L’étude approfondie de l’organisation, la dynamique et la régulation épigénétique des gènes d’ARNr 5S reste cependant difficile du fait de l’absence d’assemblage de ces régions hautemen

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Rocha, Marina Ibelli Pereira. "Controle epigenético da expressão do gene CAST, relacionado à maciez de carne em bovinos de corte." Universidade Federal de São Carlos, 2013. https://repositorio.ufscar.br/handle/ufscar/5527.

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Made available in DSpace on 2016-06-02T20:21:33Z (GMT). No. of bitstreams: 1 5633.pdf: 1339694 bytes, checksum: c96c2cb2d5b7dcda944ea18353c62f47 (MD5) Previous issue date: 2013-08-02<br>The Meat tenderness, a trate of economic importance in animal production, is influenced by the intensity of the degradation of myofibrillar proteins in post-mortem. The μ-calpain is the main enzyme responsible for meat tenderness of skeletal muscle, and, conversely, the calpastatin, which is encoded by the CAST gene, acts as endogenous inhibitor of calpain and thus decreases the extent of proteolysis in

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Lin, Yiwei. "THE LINKAGE BETWEEN TRANSCRIPTION CONTROL AND EPIGENETIC REGULATION: THE SNAIL STORY AND BEYOND." UKnowledge, 2012. http://uknowledge.uky.edu/pharmacol_etds/2.

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Epigenetic deregulation contributes significantly to the development of multiple human diseases, including cancer. While great effort has been made to elucidate the underlying mechanism, our knowledge on epigenetic regulation is still fragmentary, an important gap being how the diverse epigenetic events coordinate to control gene transcription. In the first part of our study, we demonstrated an important link between Snail-mediated transcriptional control and epigenetic regulation during cancer development. Specifically, we found that the highly conserved SNAG domain of Snail sequentially and

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Bisoni, Laura. "The I factor 5'UTR : physical properties and possible role in epigenetic control." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/11992.

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The I factor is a Long Interspersed Nuclear Element of <i>Drosophila melanogaster. </i>Transposition of the I factor occurs via an RNA intermediate and is restricted to the germline of hybrid females that have received one half of their chromosome complement from a parent devoid of active I factors. If the I factor devoid chromosomes are of maternal origin, I factor transposition is associated with lethality of the F2 embryos and high frequency of lethal mutations in the F3 generation. In contrast to its restricted pattern of transposition, I factor expression is detectable in somatic issues o

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Silva, Liliana Mâncio da. "Analysis of epigenetic factors that control expression of irna genes in Plasmodium falciparum." Tese, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/9483.

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28

Robinson, Emma. "Control of cardiac remodelling during ageing and disease by epigenetic modifications and modifiers." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275733.

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The mammalian heart is a remarkable organ in that it must provide for the cardiovascular needs of the organism throughout life, without pausing. Yet, through developmental growth to adulthood and into ageing, the mammalian heart undergoes extensive physiological, morphological and biochemical remodelling. Pivotal to the age-associated alterations in cardiac phenotype is a decline in the proliferative capacity of cardiac myocytes (CMs), which is insufficient to compensate for the basal rate of CM death over time. The terminally differentiated nature of adult CMs also underlies the inability of

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Tie, Christopher Hieng Chie. "Epigenetic control of endogenous retroviruses and their immune recognition in differentiated human cells." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038410/.

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Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. ERVs are beneficial to their hosts because their promoters can drive temporal and spatial expression of cellular genes. Aberrantly activated ERVs, however, can be detrimental. ERV transcription is therefore controlled by multiple epigenetic modifiers. One ERV repression pathway involves KAP1 and Krüppel-associated box domain-zinc finger proteins (KZNFs), which recruit KAP1 to ERVs and other repetitive sequences early in development. Little is known, in contrast, about the

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Silva, Liliana Mâncio da. "Analysis of epigenetic factors that control expression of irna genes in Plasmodium falciparum." Doctoral thesis, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/9483.

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31

Camargo, Lauren. "Expressão de RNAs não codificadores intrônicos longos em linhagens celulares humanas e o seu controle epigenético por metilação do DNA." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-10062013-104932/.

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Estudos recentes têm revelado que uma fração significativa do transcriptoma de eucariotos é composta por RNAs não codificadores longos (lncRNAs). Este trabalho investigou o padrão de expressão de um conjunto de lncRNAs originados a partir de regiões intrônicas de genes codificadores de proteínas em três linhagens celulares tumorais humanas utilizando microarranjos de DNA customizados. Realizamos uma série de análises in silico com a perspectiva de identificar propriedades globais desses transcritos, tais como a abundância relativa em diferentes tecidos, características evolutivas, estruturais

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Soufuku, Kozue. "Transcription Profiling Demonstrates Epigenetic Control of Non-retroviral RNA Virus-Derived Elements in the Human Genome." Kyoto University, 2016. http://hdl.handle.net/2433/215439.

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Ayub, Mustak Ibn. "Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:95c20af5-8167-4f9f-a136-6c48a366bbad.

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Understanding the mechanisms and nature of tumour heterogeneity is a key focus of current cancer research. Tumour heterogeneity can arise from clonal evolution and/or differentiation. This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. First, E-Cadherin variation between the cell lines LS174T and LS180 was investigated to find out whether E-Cadherin had any causal role in the difference in lumen formation between these two cell lines derived from the same tumour. These studies found no evidence of a causal role of

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Lupey-Green, Lena Nicole. "PARP1-MEDIATED EPIGENETIC CONTROL OF LATENCY AND LYTIC REACTIVATION OF THE EPSTEIN BARR VIRUS." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/463893.

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Biomedical Sciences<br>Ph.D.<br>Epstein Barr virus (EBV) is a gammaherpesvirus that infects more than 95% of the human population worldwide. EBV latent infection of B cells is associated with a variety of lymphomas and epithelial cancers and accounts for approximately 1% of all human cancers. The EBV genome persists in infected host cells as a chromatinized episome and is subject to chromatin-mediated regulation. Binding of the host insulator protein CTCF to the EBV genome has an established role in maintaining viral latency type, and in other herpesviruses, loss of CTCF binding at specific re

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Ng, Christopher W. "Recognizing epigenetic patterns that mark the control of cell state in differentiation and disease." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97978.

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Thesis: Sc. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 157-192).<br>Unlike the genomic sequence, the epigenome is dynamic, responding to and influencing the cellular state. Understanding the ways in which chromatin structure exercises control over transcriptional programs during development as well as aberrant gene expression signatures in human disease is a central challenge to biology and pathology. Despite the advance of tools to chart the chromatin landscape, m

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Hu, Guojian. "Hormonal and epigenetic control of pollination-dependent and pollination-independent fruit-setting in tomato." Phd thesis, Toulouse, INPT, 2017. http://oatao.univ-toulouse.fr/18575/1/HU.pdf.

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The flower-to-fruit transition, so-called fruit setting, is triggered by flower pollination and this process is essential for plant reproductive success, seed formation and crop yield. The underlying molecular mechanisms controlling this developmental transition remain unclear. Histone marking and DNA methylation are the main epigenetic modes for genetic reprogramming, however, their respective contribution to the fruit set-associated transcriptomic reprogramming is also unknown. To address the contribution of the two types of epigenetic regulation to fruit set, genome-wide transcriptomic prof

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Araújo, Érica Sara Souza de. "Estabilidade do controle epigenético em células humanas normais e transformadas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-11072012-075646/.

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A epigenética aborda o controle da expressão gênica através de diversos fatores que agem sob a cromatina, os melhor estudados são a metilação do DNA e a acetilação em histonas, relacionadas à repressão e ativação gênica, respectivamente. Em mamíferos, existem dois fenômenos epigenéticos interessantes: a inativação do cromossomo X (ICX) em fêmeas, que garante o equilíbrio transcricional gênico entre os sexos, e o imprinting genômico, caracterizado pela expressão monoalélica dependente da origem parental. No presente estudo, propusemos verificar a manutenção do controle epigenético em células hu

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McGregor, Chelsea P. "Snf2l Regulates Foxg1 Expression to Control Cortical Progenitor Cell Proliferation and Differentiation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23231.

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Over the past five years the role of epigenetic modifiers in brain development has become increasingly evident. In this regard, Snf2l, a homolog of the chromatin remodeling protein ISWI, was shown to have enriched expression in the brain and be important for neuronal differentiation. Mice lacking functional Snf2l have hypercellularity of the cerebral cortex due to increased cell cycle re-entry. In this thesis I demonstrate the effects of Snf2l-ablation on cortical progenitor cells including increased proliferation and cell cycle deregulation, the consequence of which is a delay in neuronal mig

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Martin, Kayla. "Epstein-Barr Virus-Induced Oncogenesis: Epigenetic Control of LMP1 Expression and LMP1-Mediated Cell Transformation." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/400541.

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Microbiology and Immunology<br>Ph.D.<br>EBV is a human gammaherpesvirus that infects approximately 95% of the population worldwide and is associated with 1% of human cancer incidence. The EBV-genome-encoded latency membrane protein 1 (LMP1) is expressed in nearly all of EBV-associated malignancies and is the major EBV oncogene. Because LMP1 is essential for both establishing a latent EBV infection and promoting tumorigenesis, defining its role in these processes is critical in order to understand EBV-associated cancer development. Due to the importance of epigenetics in regulating EBV gene exp

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Mihaylova, Yuliana. "Epigenetic control of planarian stem cell potency limits stem activity and accurately defines differentiation programs." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/32929/.

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Planarian flatworms are gaining popularity in regenerative medicine research due to the fact that they have unparalleled regeneration capacity. Their tissue recovery abilities are dependent on a pool of adult stem cells (neoblasts). Studies in the recent years have shown that epigenetic mechanisms have an important role in neoblasts’ self-renewal and differentiation properties. This thesis focuses on the study of trithorax-related genes and their function in neoblast regulation. Despite the fact that mammalian trithorax-related genes Mll3 and Mll4 are among the most frequently mutated genes in

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Grady, Patrick James Robert. "Epigenome control by chromatin modifiers: roles for histone H3 lysine modifiers in the regulation of repetitive elements." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104931.

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Thesis advisor: Hugh P. Cam<br>Chromatin is the site of numerous structural features that contribute to the regulation of the genome. Although numerous posttranslational modifications to the histone proteins that make up chromatin have been identified, it remains unclear whether and to what extent these modifications might regulate transposons and other repetitive sequences. One such modification is methylation of histone H3 lysine 4 (H3K4me), which is catalyzed by Set1 and its associated complex Set1C/COMPASS. Although H3K4me is associated with actively transcribed regions in euchromatin, an

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D’Anello, Laura <1980&gt. "Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3368/.

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Genau, Anne Christina [Verfasser], and Stefan A. [Akademischer Betreuer] Rensing. "Evolutionary conservation of epigenetic control of plant sexual reproduction / Anne Christina Genau ; Betreuer: Stefan A. Rensing." Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/122758010X/34.

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Karam, Teixeira Felipe. "Epigenetic control of repeat elements and its impact on genome activity in the model plant arabidopsis." Paris 11, 2010. http://www.theses.fr/2010PA112020.

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La méthylation de l’ADN joue un rôle majeur dans le contrôle de l’activité des génomes de plantes et de mammifères. Cette marque épigénétique cible principalement les séquences répétées et notamment les éléments transposables (TE), dont elle réprime l’activité. Chez les plantes, la perte de méthylation induite génétiquement a été décrite comme transmise de manière stable au cours des générations. Ces observations ont conduit à l’idée que la méthylation de l’ADN ne peut être restaurée après qu’elle a été compromise. Nous montrons par une analyse systématique menée chez la plante un modèle Aradi

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Benton, Gabriel Jon. "Laminin-1 mediates epigenetic control of the epithelial cadherin for breast cancer cells in three-dimensional culture." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/525216707/viewonline.

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Lay, Tan Siok. "Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development." Kyoto University, 2012. http://hdl.handle.net/2433/165021.

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Sánchez, Vásquez Estefanía. "Control epigenético-microarn de la migración de las células de la cresta neural en vertebrados." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/4100.

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Las células de la cresta neural (CCN) conforman una población transitoria presente solo en etapas muy tempranas del desarrollo embrionario de vertebrados. Estas células se caracterizan por su multipotencia y capacidad migratoria, y es sabido que defectos en el proceso de migración lleva a severos trastornos congénitos conocidos como neurocristopatias. Las CCN, para adquirir sus propiedades migratorias, sufren un proceso de transición epiteliomesénquima (TEM), similar a lo que ocurre durante el inicio de la metástasis tumoral. Se ha determinado que los microARNs conforman un grupo de reguladore

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Kim, Jin Young Leo. "METABOLIC CONTROL OF THE EPIGENOME IN GLIOBLASTOMA STEM CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case157616602610095.

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Wu, Jiejun. "Genome-wide analysis of epigenetics and alternative promoters in cancer cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1187019769.

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Casas, Delucchi Corella Susana [Verfasser], M. Cristina [Akademischer Betreuer] Cardoso, and Adam [Akademischer Betreuer] Bertl. "Epigenetic control of DNA replication dynamics in mammals / Corella Susana Casas Delucchi. Betreuer: M. Cristina Cardoso ; Adam Bertl." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2011. http://d-nb.info/1105562611/34.

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