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Journal articles on the topic 'Epilepsy and Dizziness'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Lee, Wankiun, and Jae-Moon Kim. "Dizziness in Patients with Vestibular Epilepsy." Research in Vestibular Science 22, no. 1 (2023): 7–13. http://dx.doi.org/10.21790/rvs.2023.22.1.7.

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Objectives: Vestibular epilepsy refers to epilepsy in which vertigo is the sole or main symptom of a seizure. However, epilepsy is rarely considered as a differential diagnosis in patients complaining of dizziness. Here, we reviewed ten cases of vestibular epilepsy and analyzed the dizziness complained by the patient.Methods: In this study, the medical records of dizziness patients with epileptic discharges observed on electroencephalogram were retrospectively analyzed. Patients who had other obvious causes of dizziness, lacked a description of dizziness, or were not taking antiseizure medicat

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Wu, Ning, Xiaojun Zhang, and Yanqiang Wang. "Vertigo or dizziness as the first presentation of epilepsy: A case report." Advanced Neurology 1, no. 3 (2022): 140. http://dx.doi.org/10.36922/an.v1i3.140.

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Vertigo or dizziness is a common neurological symptom, but it is rarely regarded as the first presenting symptom of epilepsy. Patients who present with vertigo as the first symptom of epilepsy may be misdiagnosed or missed diagnose. We report a case presenting with vertigo or dizziness as the first manifestation of epilepsy and review relevant literature. A 71-year-old female patient sought medical attention in view of paroxysmal dizziness for a year that progressively worsened over the course of 1 week. Initially, her dizziness occurred 2 or 3 times a month, lasting for less than a minute eac

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McGuire, Sara, Gustavo Silva, Darshan Lal, et al. "Safety and Efficacy of Brivaracetam in Pediatric Refractory Epilepsy: A Single-Center Clinical Experience." Journal of Child Neurology 35, no. 2 (2019): 102–5. http://dx.doi.org/10.1177/0883073819879276.

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Brivaracetam is a new antiepileptic drug with limited data in children. The objective of this study was to assess the efficacy/tolerability of brivaracetam. This is a retrospective chart review of children/adolescents with refractory epilepsy treated with brivaracetam from 2016 to 2018. The primary outcome was seizure reduction (decrease in seizure frequency >50%). Twenty-three patients were identified. Mean age at initiation was 12.5 years. Fourteen were females. Epilepsy was focal in 11, generalized in 6, and mixed in 3. Average dose was 3.9 mg/kg/d. The mean duration of treatment was 8.2

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Ataniyazov, Maksud Rakhimov Nurillo Tohirov Zhonibek. "COGNITIVE IMPAIRMENT IN PATIENTS WITH COVID-19." «Zamonaviy dunyoda amaliy fanlar: muammolar va yechimlar» nomli ilmiy, masofaviy, onlayn konferensiya 1, no. 30 (2022): 12–13. https://doi.org/10.5281/zenodo.7397223.

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COVID-19 has a wide range of clinical manifestations. During the pandemic, neurological manifestations were demonstrated in patients with COVID-19, including cognitive impairment. In a study conducted in Wuhan, Hubei Province, 36.4% of patients had some neurological manifestations, while central organs were more often affected (dizziness, headache, changes in consciousness, stroke, ataxia and epilepsy).

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Kwon, Jae Young, Min-Tae Jeon, Un Ju Jung, Dong Woon Kim, Gyeong Joon Moon, and Sang Ryong Kim. "Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy." Advances in Nutrition 10, no. 5 (2019): 778–90. http://dx.doi.org/10.1093/advances/nmz047.

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ABSTRACTEpilepsy is a chronic neurological disorder that affects many people worldwide. Temporal lobe epilepsy is the most common and most studied type of epilepsy, but the pathological mechanisms underlying this condition are poorly understood. More than 20 antiepileptic drugs (AEDs) have been developed and used for the treatment of epilepsy; however, 30% of patients still experience uncontrolled epilepsy and associated comorbidities, which impair their quality of life. In addition, various side effects have been reported for AEDs, such as drowsiness, unsteadiness, dizziness, blurred or doubl

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Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "The Complex Relationship between Drugs and Epileptic Patients: A Comprehensive Exploration." Journal of Trauma, Orthopaedic and Urological Nursing 2, no. 1 (2023): 7–10. https://doi.org/10.5281/zenodo.10416835.

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<em>Epilepsy is a neurological disorder manifested by recurrent seizures, influencing millions of people worldwide. Anti-epileptic drugs (AEDs) are treated as primary treatment for epilepsy. Anti-epileptic drugs show their action on various targets particularly within the brain, namely ion channels, neurological transmitter system. Types of Anti-epileptic drugs include calcium channel blockers, GABA enhancers, glutamate receptor antagonist and sodium channel blockers. Side effects of AEDs are dizziness or drowsiness, life style factors namely sleep, stress management. Some studies indicate tha

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Zhao, Zhihong, and Jie Qin. "Limb-shaking transient ischemic attack in posterior circulation ischemia: a case report." Journal of International Medical Research 50, no. 12 (2022): 030006052211423. http://dx.doi.org/10.1177/03000605221142361.

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Limb-shaking transient ischemic attack (LS-TIA) is a rare clinical manifestation of steno-occlusive carotid lesions. Reports of LS-TIA caused by posterior circulation ischemia are rare. Here, the case of a 56-year-old male patient with a history of epilepsy, who presented with dizziness, nausea and vomiting, is reported. Initial brain magnetic resonance imaging (MRI) indicated no signs of acute ischemia, and the patient’s symptoms had not relieved despite drug administration to treat dizziness. During a vestibular function test on the next day, he developed sudden left-limb shaking without dis

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Naveen, P., G. Sarala, D. Manoj Chandra, et al. "Retrospective Review of Treatment Outcomes in Epilepsy Patients: Seizure Control and Medication Side Effects." Journal of Pharmacy and Bioallied Sciences 16, Suppl 3 (2024): S2425—S2427. http://dx.doi.org/10.4103/jpbs.jpbs_246_24.

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ABSTRACT Background: Epilepsy management requires balancing seizure control with minimizing medication side effects. This retrospective review examines treatment outcomes in epilepsy patients, focusing on seizure control and medication-related adverse effects. Methods: Medical records of epilepsy subjects treated tertiary care center between 2017 and 2022 were retrospectively reviewed. Data on demographic characteristics, seizure control, medication regimen, and side effects were collected and analyzed. Results: A total of 200 subjects were included. Sixty percent of subjects achieved total se

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Kumar, Amit, and Sambhu Prasad. "Levetiracetam Induced Significant Weight Loss in a Patient with Complex Partial Seizure - A Case Report." International Journal of Research and Review 12, no. 2 (2025): 393–94. https://doi.org/10.52403/ijrr.20250246.

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Initially developed as a nootropic agent, levetiracetam is now widely used as a treatment for convulsive disorders including partial seizures, myoclonic seizures, and idiopathic generalised epilepsy. Levetiracetam has also been found to be useful in acute mania, and as an add-on treatment for major depression [1]. The most common side effects of levetiracetam include drowsiness, dizziness, ataxia, diplopia, memory impairment and paresthesia. There are very few case reports showing significant weight loss occurring due to use of levetiracetam. We are reporting such a case, where a 24 year old m

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Mutanana, Ngonidzashe. "Challenges Associated with Anti-epilepsy Medication and Use of Complementary or Alternative Medicines among People with Epilepsy in Rural Communities of Zimbabwe." Malaysian Journal of Medical and Biological Research 6, no. 2 (2019): 77–84. http://dx.doi.org/10.18034/mjmbr.v6i2.475.

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The main objective of this study was to analyze challenges associated with anti-epilepsy medication and use of complementary or alternative medicines among people with epilepsy in rural communities of Zimbabwe. The study opted for qualitative research because it is culturally specific and data collected is contextually rich. The target population was people with epilepsy and caregivers of children with epilepsy and using a snowball sampling technique, a sample of 15 people with epilepsy and 5 caregivers of children with epilepsy was selected. The study purposively selected 2 traditional healer

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R., Rethinam* R. Jeyachandran. "MICROPROPAGATION FROM AGERATUM CONYZOIDES L." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 674–80. https://doi.org/10.5281/zenodo.1036577.

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An in vitro micropropagation protocol has been standardized from shoot tip, nodal and leaf explants of Ageratum conyzoides L. belongs to family Cucurbitaceae is an endemic medicinal plant used for the treatment of hepatitis, eczema, epilepsy, dizziness diarrhea, and fever. Murashige and Skoog, (1962) medium along with the various hormone compositions were used. Callus culture was initiated and established from leaf explants, on MS medium fortified with NAA (2.0 mg/L) 2, 4 - D (2.5 mg/L). Multiple shoots were regenerated from shoot tip explants of NAA (0.5 mg/L) and BAP (1.0 mg/L) and nodal exp

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Deng, Chujun, Huize Chen, Zeyu Meng, and Shengxi Meng. "Gastrodin and Vascular Dementia: Advances and Current Perspectives." Evidence-Based Complementary and Alternative Medicine 2022 (April 12, 2022): 1–13. http://dx.doi.org/10.1155/2022/2563934.

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Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is th

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M’bayo, Tenema, Michal Tomek, Clifford Kamara, and Durodami Lisk. "Psychiatric comorbidity in African patients with epilepsy – Experience from Sierra Leone." International Journal of Epilepsy 04, no. 01 (2017): 026–30. http://dx.doi.org/10.1016/j.ijep.2016.12.002.

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Abstract Objective Epilepsy is associated with a significant burden of psychiatric comorbidity, including depression and anxiety disorders. However, paucity of data exists regarding the impact of epilepsy on mental health of patients in the setting of sub-Saharan Africa, where these comorbidities are under-recognized and under-treated. We carried out a cross-sectional descriptive study to investigate the prevalence and determinants of depression and anxiety among people with epilepsy in Sierra Leone. Method A screening tool previously validated in the primary healthcare setting in Zambia was a

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Fatia Murni Chamida and Nirmala Muflihatul Khalida. "Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report." Asian Journal of Health Research 2, no. 1 (2023): 77–81. http://dx.doi.org/10.55561/ajhr.v2i1.76.

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gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia. Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and

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Patil, S. B., and S. A. Deshmukh. "A Review on Taxonomy, Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Caesalpinia mimosoides Lam. (Caesalpinaceae)." Asian Journal of Biology 17, no. 3 (2023): 29–42. http://dx.doi.org/10.9734/ajob/2023/v17i3325.

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Caesalpinia mimosoides Lam. has been widely studied, although it still has the potential to be explored, because it comprises a variety of chemical compounds which have diverse biological activities. The species have, variety of chemical compounds that are present, emphasizing the importance of quality control to distinguish the species. The phytochemicals have importance for their effects on inflammation, anti-microbial, anti-diabetic, anti-oxidant activity especially the Alzheimer’s Disease. In addition, other pharmacological efficacious, such as epilepsy, dizziness, cardiovascular diseases

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Farooq, Fahad, Gurdeep Singh, Farooq Ahmad, et al. "KEPPRA (Levetiracetum) VS EPIVAL (Sodium Valporate) to control generalized tonic clonic seizures." Professional Medical Journal 27, no. 12 (2020): 2648–55. http://dx.doi.org/10.29309/tpmj/2020.27.12.4244.

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Objective: This present study is design to assess the efficacy and frequency of side effects with a newer anti-epileptic agent levertiracetum while comparing an older anti-epileptic, Sodium Valproate, in the patients with generalized tonic colonic epilepsy. Material & Methods: Patients with GTC epilepsy had been allocated in two groups, A and B, Group A was given Sodium valproate while group B was given levertiracetum. Study Design: Randomized Control Trial. Setting: Fatima Memorial Hospital, Lahore and Allied Hospital, Faisalabad. Period: December, 2017 to December, 2018. Results: Seventy

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Rangarajan, Punitha, Kulandaiammal Moorthy, and Arunan Subbiah. "Observational study on the utilization pattern of adjuvant anti-epileptics and their adverse effects." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 170. http://dx.doi.org/10.18203/2319-2003.ijbcp20195781.

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Background: Epilepsy is a disease characterized by an enduring predisposition to generate epileptic seizures. Pharmacological therapy is the cornerstone of treatment of epilepsy. In more than 50% patients seizure not controlled with first-line anti-epileptic drugs so added with adjuvant drugs. Therefore adjuvant anti-epileptic drugs play an important role in preventing seizure remission in known epilepsy patients. Observational study was to evaluate the utilisation pattern of adjuvant anti-epileptic drugs and to assess their clinical correlation and observe the adverse effects of the adjuvant

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Guo, Han, Dongmei Cheng, Cong Zhang, and Fang Xue. "The Pharmacological Effects of Gastrodin and the Progress in the Treatment of Neurological Disorders." American Journal of Chinese Medicine 53, no. 03 (2025): 803–31. https://doi.org/10.1142/s0192415x25500302.

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Gastrodia elata Blume, a traditional medicinal herb primarily used in Asian countries such as China, has long been valued for treating headaches, dizziness, spasms, epilepsy, strokes, forgetfulness, and other ailments. Gastrodin, a glycoside analog and major bioactive component of Gastrodia elata Blume, has garnered significant scientific attention owing to its extensive pharmacological effects. It is commonly obtained through plant extraction, chemical synthesis, and biosynthesis. Gastrodin exhibits remarkable modulatory effects on the central nervous system (CNS), with promising applications

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Vergara, Maria Beatriz Tiezzi. "EFICÁCIA E SEGURANÇA DA LACOSAMIDA NO TRATAMENTO DA EPILEPSIA PEDIÁTRICA." Revista ft 29, no. 144 (2025): 01–02. https://doi.org/10.69849/revistaft/ch1020250321501.

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Epilepsy is a chronic neurological condition that frequently affects children, often accompanied by cognitive and emotional comorbidities. Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of voltage-gated sodium channels, aiding seizure control. This study conducted a narrative literature review using databases such as PubMed and BVS, selecting studies published between 2020 and 2025. Findings indicate that LCM significantly reduces seizure frequency in children, particularly with long-term treatment. The most common adverse effects include drowsiness and dizziness

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Chang, Won Seok, Midori Nakajima, Ayako Ochi, et al. "Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB." Journal of Neurosurgery: Pediatrics 25, no. 1 (2020): 78–82. http://dx.doi.org/10.3171/2019.7.peds1948.

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Advanced dynamic statistical parametric mapping (AdSPM) with magnetoencephalography (MEG) was used to identify MRI-negative epileptogenic lesions in this report. A 15-year-old girl had MRI-negative and pharmacology-resistant focal-onset epilepsy. She experienced two types of seizures. Type I consisted of her arousal from sleep, staring, and a forced head-turning movement to the left, followed by secondary generalization. Type II began with an aura of dizziness followed by staring and postictal headache with fatigue. Scalp video-electroencephalography (EEG) captured two type I seizures originat

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Ismail, Mouhamad Hussein, and Robert Powell. "096 Perampanel: real life experience in swansea." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 12 (2019): A29.4—A30. http://dx.doi.org/10.1136/jnnp-2019-abn-2.98.

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IntroductionPerampanel is a selective, non-competitive AMPA receptor antagonist with a broad-spectrum activity. The aim of this study was to evaluate the efficacy and tolerability of Perampanel in an unselected group of patients with epilepsy treated at a single centre.MethodsPatients prescribed Perampanel in Morriston Hospital were included in the study. We recorded epilepsy type and duration, and side effects of treatment. The efficacy was measured by the frequency of seizures at various time points after commencing PerampanelResults39 patients were included, 53.8% (21/39) male and 46.2% (18

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Mohammadi, Tayebeh, Jafar Nasiri, Mohammad Reza Ghazavi, Omid Yaghini, and Neda Hoseini. "Efficacy of Lacosamide Add-on Therapy on Refractory Focal Epilepsies in Children and Adolescents." Journal of Research in Pharmacy Practice 11, no. 3 (2022): 109–15. http://dx.doi.org/10.4103/jrpp.jrpp_86_21.

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ABSTRACT Objective: Epilepsy is a chronic neurological disorder that affects 0.5%–1% of children. 30%–40% of patients are resistant to current anti-epileptic drugs. Lacosamide (LCM) appeared to be effective, safe, and well tolerated in children and adolescents. This study was aimed to evaluate whether LCM could be an effective add-on therapy in children with refractory focal epilepsies. Methods: This study was conducted from April 2020 to April 2021 in Imam Hossein Children Hospital, Isfahan, Iran. We included 44 children aged 6 months to 16 years with refractory focal epilepsy (based on Inter

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Türk Kalkan, Tuğba, Devrim Tarakçi, Gamze Kiliç, and Cengiz Çelikyurt. "Investigation of the Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) and Vestibular Rehabilitation in Patients with Unilateral Vestibular Hypofunction." Medicina 61, no. 5 (2025): 872. https://doi.org/10.3390/medicina61050872.

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Background: Vagus nerve stimulation (VNS) is a frequently used neuromodulation method in recent years. While the mechanism of improvement in diseases such as epilepsy, dementia, and depression is being studied, its potential effect on vestibular dysfunction is also being investigated. The aim of our study was to investigate the effect of transcutaneous auricular VNS (taVNS) on the vestibular symptoms of unilateral vestibular hypofunction (UVH). Methods: Forty patients diagnosed with UVH were randomly divided into two groups. Group 1 received vestibular rehabilitation. Group 2 received taVNS an

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Egunsola, Oluwaseun, Imti Choonara, and Helen Sammons. "SAFETY OF LAMOTRIGINE IN PAEDIATRICS: A SYSTEMIC REVIEW." Archives of Disease in Childhood 101, no. 1 (2015): e1.68-e1. http://dx.doi.org/10.1136/archdischild-2015-310148.70.

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BackgroundLamotrigine has been increasingly used for the treatment of paediatric epilepsy. It is the most commonly prescribed new generation antiepileptic drug in the UK.ObjectivesTo identify adverse drug reactions associated with lamotrigine in children, compare the safety profile with other antiepileptic drugs and identify all clinical studies and case reports involving lamotrigine safety in children.MethodsDatabases EMBASE (1974-November 2013), Medline (1946-November 2013), PubMed and the Cochrane library for randomised controlled trials were searched for original research or reports in whi

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Kim, Dong Wook, Jun-Sang Sunwoo, and Sang Kun Lee. "Incidence and localizing value of vertigo and dizziness in patients with epilepsy: Video-EEG monitoring study." Epilepsy Research 126 (October 2016): 102–5. http://dx.doi.org/10.1016/j.eplepsyres.2016.07.002.

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Anwar, T. T. Muhammed, P. P. Muhamed Faris, and ,. Thansiha. "A Systematic Review on Lamotrigine Induced Skin Rashes." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 146–51. http://dx.doi.org/10.22270/jddt.v11i1.4633.

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Lamotrigine is a newer anti-epileptic drug synthesised in 1980s and approved by USFDA in 1994. It is mainly used for treating paediatric epilepsy and one of the frequently prescribing newer anti- epileptic drugs in European countries. In English scenario, lamotrigine is suggested as monotherapy for recently identified partial seizures (localized seizure) in children as its first line drug. Lamotrigine is recommended for generalized seizures as second line drug and as add on therapy in intractable generalized epilepsy. It is a treatment option after sodium valproate and ethosuximide for petit-m

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Kristanto, Andre. "Epilepsi bangkitan umum tonik-klonik di UGD RSUP Sanglah Denpasar-Bali." Intisari Sains Medis 8, no. 1 (2017): 69–73. http://dx.doi.org/10.15562/ism.v8i1.105.

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Introduction: Epilepsy is a neurological disease that is characterized by episodes of seizures which can be accompanied by loss of consciousness of the patient. Although it is usually accompanied by loss of consciousness, there are several types of seizures without loss of consciousness. The disease is caused by the instability of electrical charges in the brain which in turn interfere with muscle coordination and manifest in muscle stiffness or repetitive pounding on the muscle. Classification of epileptic seizure according to ILAE 1981 include some general seizures, partial / focal seizures,

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Maslov, N. E., N. V. Yuryeva, E. I. Khamtsova, and A. A. Litvinova. "Neuroimaging predictors of structural epilepsy in the COVID-19 catamnesis." Epilepsy and paroxysmal conditions 13, no. 3 (2021): 274–85. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2021.092.

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Respiratory system pathology is the most common clinical disorder associated with COVID-19. However, there are also lesions of the immune, cardiovascular, genitourinary, endocrine systems, and digestive tract. In addition, there are numerous reports on infection-related neurological manifestations, which can be divided into 3 groups: central nervous system manifestations (headache and dizziness, stroke, encephalopathy, encephalitis, acute myelitis), lesions of the peripheral nervous system (anosmia, Guillain–Barre syndrome), secondary lesions in the skeletal muscles. Brain damage that occurs d

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Viteva, Ekaterina Ivanova, and Zahari Ivanov Zahariev. "Oxcarbazepine effectiveness as add-on therapy in Bulgarian patients with drug-resistant epilepsy." World Journal of Advanced Research and Reviews 3, no. 3 (2019): 001–10. https://doi.org/10.5281/zenodo.4309940.

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The study purpose was to perform an open, prospective study on various aspects of oxcarbazepine (OCBZ) effectiveness in Bulgarian patients with drug-resistant epilepsy. The study was performed with the participation of patients with epilepsy who attended the Clinic of Neurology at the University Hospital in Plovdiv, Bulgaria. Patients completed diaries about seizure frequency, severity, and adverse events. There were regular documented visits at 3 or 6 months during the first year of treatment with OCBZ and at 6 months afterwards, with dynamic assessment of seizure frequency, severity, adverse

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Buck, Marcia L., and Howard P. Goodkin. "Use of Lacosamide in Children with Refractory Epilepsy." Journal of Pediatric Pharmacology and Therapeutics 17, no. 3 (2012): 211–19. http://dx.doi.org/10.5863/1551-6776-17.3.211.

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OBJECTIVES Lacosamide was approved by the US Food and Drug Administration in 2008 for adjunctive therapy for focal onset seizures in patients 17 years of age and older. The efficacy of this agent in adults has led clinicians to consider lacosamide for children with refractory seizures. METHODS The MEDLINE database (1950–June 2012) was searched for abstracts containing lacosamide as the key term. Additional references were obtained from the manufacturer and the bibliographies of the articles reviewed. All available English-language case reports and clinical trials were included in the evaluatio

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G., Sowjanya E. Raja Sree S. Disharani1 M. Neeraja Y.Lavanya M. Niranjan babu. "STEVEN JOHNSON SYNDROME INDUCED BY CARBAMAZEPINE TREATMENT IN AN EPILEPTIC PATIENT – A CASE REPORT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4274–76. https://doi.org/10.5281/zenodo.1254135.

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Objectives: Carbamazepine is most commonly used for the treatment of seizure disorders, neuropathic pain and bipolar disorders. It is associated with adverse effects such as nausea, vomiting, drowsiness, dizziness, head ache, impairement in motor coordination, aplastic anaemia, agranucytosis. Rarely life threatening cutaneous reaction such as stevensjohnson syndrome (SJS) or toxic epidermal necrolysis (TEN) due to carbamazepine therapy are more common in people with human leukocyte antigen allele HLA-B*1502. Methodology: We report a case of SJS due to carbamazepine therapy in a patient with ep

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Kuzmanova, Rumyana, та I. Vaneva. "Advantages of eslicarbazepine in the treatment of patients with fоcalepilepsy". Bulgarian Neurology 25, № 1 (2024): 1–4. https://doi.org/10.5281/zenodo.15369230.

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Epilepsies are among the most common chronic disorders of the brain and affect approximately 70 million people worldwide. The management of epilepsy is mainly symptomatic, aimed at reducing the risk of seizure recurrence. Despite the availability of many therapeutic options, more than 50% of patients do not achieve seizure freedom with initial monotherapy and despite combination therapy seizures remain uncontrolled in approximately one third of patients.The most frequent type of seizure is the partial-onset (focal) seizure.Eslicarbazepine acetate is a new antiepileptic drug, third-generation r

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Bereda, Gudisa. "Ilae classification of seizures and antiepileptic medications apothegmatic: hereafter advancement and clinical practice." Journal of Psychology & Clinical Psychiatry 13, no. 1 (2022): 3–7. http://dx.doi.org/10.15406/jpcpy.2022.13.00705.

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Introduction: The Antiepileptic medications are frequently categorized into divisions such as ‘first-generation’ (i.e., carbamazepine, phenobarbital, phenytoin, primidone, and valproate) and ‘second-generation’ (lamotrigine, levetiracetam, felbamate, gabapentin, topiramate, tiagabine, oxycarbazepine, zonisamide, and pregabalin). Chronic phenytoin ingestion leads to its impact in the cerebral cortex, resulting in atrophy of cerebellum, cause ataxia and nystagmus. Objective: To recapitulate the International league against epilepsy classifications, first treatment for epilepsy based on their cla

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Balali, Pargol, Seyedeh Sajedeh Marashi, Elmira Agah, et al. "Safety and Efficacy of Memantine in Improving Cognitive Function of Patients with Epilepsy." Caspian Journal of Neurological Sciences 8, no. 4 (2022): 197–205. http://dx.doi.org/10.32598/cjns.8.31.6.

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Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There is still no approved medication for the treatment of this problem. Objectives: The present study aims to assess the safety and efficacy of memantine in improving the cognitive function of patients with epilepsy. Materials & Methods: This is a pilot, randomized, double-blind, placebo-controlled, parallel-group clinical trial, conducted in a hospital in Tehran, Iran during 2018-2019. Participants were randomly allocated to receive memantine (5 mg/day in the first eight weeks and 10 mg/day in t

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Nilofar, Yasmin, Md.Shahzada, and Ahmad Ishteyaque. "To Analyse the Prescription Trend of Anti-Epileptic Drugs: An Observational Study." International Journal of Current Pharmaceutical Review and Research 16, no. 03 (2024): 734–37. https://doi.org/10.5281/zenodo.13168946.

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AbstractAim: To analyze the prescription trend of anti-epileptic drugs at a tertiary care center in Bihar region.Materials and Methods: The observational study at Department of Pharmacology, Netaji Subhas medicalCollege and Hospital, Bihta, Patna, Bihar, India. Prescription patterns were examined for epilepsy-diagnosed adultoutpatients. Over 3 months, 100 prescriptions were randomly gathered. Patient demographics, clinical diagnosis,epilepsy type, AED type, medication dosage, and frequency will be noted. We determined the average prescriptionmedication count.Results: Epilepsy types: 79% of pre

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Chinvarun, Yotin, Rafael Toledano Delgado, Alexandra Astner-Rohracher, et al. "Perampanel Monotherapy for Focal and Generalized Epilepsy in Clinical Practice." Acta Neurologica Scandinavica 2023 (February 7, 2023): 1–12. http://dx.doi.org/10.1155/2023/2852853.

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Objectives. To investigate the effectiveness, safety, and tolerability of perampanel (PER) when used as monotherapy to treat focal or generalized epilepsy in everyday clinical practice, using data from the PERMIT study. Methods. PERMIT was a pooled analysis of 44 real-world studies from 17 countries, in which people with focal and generalized epilepsy were treated with PER. This post hoc analysis included people with epilepsy (PWE) from PERMIT who were treated with PER monotherapy at baseline. Retention and effectiveness were assessed after 3, 6, and 12 months. Effectiveness assessments includ

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Elmardenly, Ahmed, Zekra Aljehani, Abdullah Tamim, Anas Alyazidi, and Osama Muthaffar. "Efficacy and Safety of Perampanel in Children with Drug-Resistant Focal-Onset Seizures: A Retrospective Review." Children 10, no. 6 (2023): 1071. http://dx.doi.org/10.3390/children10061071.

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Background: Epilepsy is one of the most common neurological disorders. Existing antiseizure medications (ASMs) are still unable to control seizures in one-third of these patients, making the discovery of antiseizure therapies with novel mechanisms of action a necessity. Aim of the Study: This study aimed to determine the safety and efficacy of perampanel (PER) as an adjuvant treatment for children with drug-resistant focal-onset seizures with or without focal to bilateral tonic-clonic seizures. Patients and methods: This is a single-center retrospective study of 38 epileptic pediatric patients

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Strok, A. B., S. B. Bashirova, R. R. Bashirov, and E. V. Lyasotskaya. "Study of the use of flunarizine in the treatment of pediatric patients." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 3 (June 10, 2025): 59–61. https://doi.org/10.33920/med-13-2503-11.

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The drug flunarizine belongs to the group of L-type calcium channel blockers. It has a vasodilating effect with a predominant influence on the vessels of the brain, is used to treat dizziness, and has histamine-blocking activity. There is also evidence that flunarizine is an antagonist of dopamine D2 receptors, blocks sodium channels and calcium channels of the P/Q type in the brain, modulates neurosecretion, and has an impact on the serotonergic system. Flunarizine is used to treat diseases of the nervous system. According to the anatomical, therapeutic, and chemical classification, its code

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Viteva, Ekaterina Ivanova, and Zahari Ivanov Zahariev. "Lamotrigine: how effective is it as add-on therapy in Bulgarian patients with drug-resistant epilepsy." GSC Biological and Pharmaceutical Sciences 8, no. 3 (2019): 109–21. https://doi.org/10.5281/zenodo.4284521.

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The study purpose was to perform an open, prospective study on various aspects of Lamotrigine (LTG) effectiveness in Bulgarian patients with drug-resistant epilepsy. The study was performed with the participation of patients with epilepsy who attended the Clinic of Neurology at the University Hospital in Plovdiv, Bulgaria. The patients completed diaries about seizure frequency, severity, and adverse events. There were regular documented visits at 3 or 6 months during the first year of treatment with LTG and at 6 months afterwards, with dynamic assessment of seizure frequency, severity, adverse

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Fröscher, Walter, Katja R. Schier, Markus Hoffmann, et al. "Topiramate: a prospective study on the relationship between concentration, dosage and adverse events in epileptic patients on combination therapy." Epileptic Disorders 7, no. 3 (2005): 237–48. http://dx.doi.org/10.1684/j.1950-6945.2005.tb00128.x.

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Rationale The relationship between topiramate (TPM) concentration, dosage and adverse events in patients with epilepsy is still controversial. We therefore performed a prospective study in patients with poorly controlled epilepsy treated with TPM, predominantly in combination with other antiepileptic drugs. The goal of the study was to investigate the relationship between the occurrence of adverse events due to TPM and its serum concentration or dosage, respectively. Methods The relationship between the occurrence of adverse events and TPM serum concentration or dosage, respectively, was exami

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Bauer, Sebastian, Laurent M. Willems, Esther Paule, et al. "The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience." Therapeutic Advances in Neurological Disorders 10, no. 2 (2016): 103–26. http://dx.doi.org/10.1177/1756285616675777.

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Lacosamide (LCM) is approved for anticonvulsive treatment in focal epilepsy and exhibits its function through the slow inactivation of voltage-gated sodium channels (VGSCs). LCM shows comparable efficacy with other antiepileptic drugs (AEDs) licensed in the last decade: in three randomized placebo-controlled trials, significant median seizure reduction rates of 35.2% for 200 mg/day, 36.4–39% for 400 mg/day and 37.8–40% for 600 mg/day were reported. Likewise, 50% responder rates were 38.3–41.1% for 400 mg/day and 38.1–41.2% for 600 mg/day. Similar rates were reported in post-marketing studies.

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Singh, Rajinder P., and Jorge J. Asconapé. "A Review of Eslicarbazepine Acetate for the Adjunctive Treatment of Partial-Onset Epilepsy." Journal of Central Nervous System Disease 3 (January 2011): JCNSD.S4888. http://dx.doi.org/10.4137/jcnsd.s4888.

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Eslicarbazepine acetate (ESL) is a novel antiepileptic drug indicated for the treatment of partial-onset seizures. Structurally, it belongs to the dibenzazepine family and is closely related to carbamazepine and oxcarbazepine. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL is a pro-drug that is rapidly metabolized almost exclusively into S-licarbazepine, the biologically active drug. It has a favorable pharmacokinetic and drug-drug interaction profile. However, it may induce the metabolism of oral contraceptives and should be used with caution in females of c

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Majumdar, Sumit, Subroto Chakrabartty, Swati Chakravarti, and Soumya Roy. "Excessive Cry in a 5-Month-Old Infant Possibly due to Abdominal Epilepsy." Journal of Pediatric Epilepsy 06, no. 04 (2017): 186–89. http://dx.doi.org/10.1055/s-0037-1608868.

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AbstractExcessive and unexplained cry is a common problem with infants. Most of the causes are benign or easily treatable, with exception of a few. However, we encountered a 5-month-old, otherwise healthy male infant, who used to cry inconsolably every day on the afternoon for about 3 hours and then used to fall asleep. This had been going on for the last 6 weeks. After waking up, infant seemed perfectly normal. History, physical examination, and routine investigations failed to diagnose the cause. An electroencephalogram showed epileptic abnormalities. The “crying episodes” disappeared after

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Coppola, A., S. Izumoto, X. Rodríguez-Osorio, et al. "P11.08.A Clinical practice evidence for perampanel in epilepsy patients with tumour aetiology." Neuro-Oncology 24, Supplement_2 (2022): ii56—ii57. http://dx.doi.org/10.1093/neuonc/noac174.197.

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Abstract Background Real-world studies can provide information on those patients routinely excluded from clinical trials such as epilepsy patients with tumour aetiology. Perampanel (PER) is a once-daily oral anti-seizure medication for focal-onset seizures, with or without focal to bilateral tonic-clonic seizures, and generalised tonic-clonic seizures. This study evaluated PER’s effectiveness and safety when used in everyday clinical practice to treat epilepsy patients with tumour aetiology. Material and Methods Patients with epilepsy with tumour aetiology were identified from a pooled analysi

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Kothare, Sanjeev V., Ignacio Valencia, Divya S. Khurana, Huntley Hardison, Joseph J. Melvin DO, and Agustin Legido. "Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy." Epileptic Disorders 6, no. 4 (2004): 267–70. http://dx.doi.org/10.1684/j.1950-6945.2004.tb00075.x.

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The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA). Recently, topiramate and lamotrigine have also been shown to be effective. The objective of this study was to evaluate the efficacy and tolerability of zonisamide (ZNS) in the treatment of JME. We retrospectively analyzed the records of 15 patients (three M, 12 F, ages 11‐20 years) diagnosed with JME at our institution during 2001‐2003, and treated with ZNS. Generalized tonic‐clonic (GTC), myoclonic and absence seizure response was assessed. The ZNS dose range was 200‐500 mg/day (2.0‐8.5 mg/kg/day). ZNS was sta

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Latimer, Dustin R., Amber N. Edinoff, Rachel D. Ruff, et al. "Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABAA Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications." Neurology International 13, no. 2 (2021): 252–65. http://dx.doi.org/10.3390/neurolint13020026.

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Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment. Current FDA approved drugs have been shown to have similar efficacy; however, they all share a commonality of having side effects that have the potential to significantly reduce a patient’s quality of life. Cenobamate, a newly-FDA approved drug used to treat partial-onset seizures in adult patients, has demonstrated promise in that it works on t

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Bangalore, Priyadarshini, Changez Jadun, Brenden Davies, and Roby Abraham. "112 Spontaneous intracranial hypotension presenting as postural head tremor and gait ataxia." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 12 (2019): e33.2-e33. http://dx.doi.org/10.1136/jnnp-2019-abn-2.111.

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We present a 65 year old lady with 30 year history of chronic daily headache without postural changes after a road traffic accident presented with three months history of postural head and upper limb tremor, progressive ataxia, dizziness, mild confusion and few falls. She had worsening of epilepsy with partial status prompting acute hospital admission. Symptoms exacerbated on standing and she preferred lying down most of the time. Previous history of temporal lobe epilepsy and Anterior Cervical Decompression and Fusion.Examination: She had a head tremor which exaggerated on upright posture alo

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Chowdhury, Suman, and Mohammad Najim Uddin. "A Case of Neurocysticercosis Clinically Mimicking Epilepsy: Report from Remote Hilly Area of Bangladesh." Bangladesh Journal of Infectious Diseases 3, no. 1 (2017): 24–27. http://dx.doi.org/10.3329/bjid.v3i1.32587.

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Neurocysticercosis (NCC) is considered a common infection of the nervous system caused by the Taenia solium and is known to be the primary cause of preventable epilepsy in many developing countries. NCC is commonly resulted by the ingestion of Taenia solium eggs after consuming undercooked pork, or contaminated water. The parasite can grow in the brain and spinal cord within the nervous system, causing severe headache and seizures beside other pathological manifestations. People in North Eastern hilly areas of Bangladesh are very much fond of Pork meat. Here in this case report, an elderly ind

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Carreño, Mar, Eugen Trinka, and Martin Holtkamp. "Optimising Epilepsy Therapy – Searching for the Evidence – Looking Beyond the Data." European Neurological Review 10, no. 2 (2015): 164. http://dx.doi.org/10.17925/enr.2015.10.02.164.

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There is now an extensive range of anti-epileptic drugs (AEDs) available including older established treatments and a newer generation of medications. The choice of drugs and what constitutes optimal therapy, however, is unclear due to limitations in the data supporting their use, particularly among the newer treatments. In clinical trials of monotherapy, a treatment is required to show only non-inferiority to another benchmark treatment. In trials of polytherapy, comparisons are limited to placebo. It is therefore necessary to look beyond the study data and consider other parameters to ascert

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Viteva, Ekaterina I., and Zahari I. Zahariev. "Levetiracetam effectiveness as add-on therapy in Bulgarian patients with drug-resistant epilepsy." Folia Medica 63, no. 2 (2021): 234–41. http://dx.doi.org/10.3897/folmed.63.e54994.

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Introduction: There are no reliable prospective studies on the effectiveness of LEV in Bulgarian adult patients with drug-resistant epilepsy. Aim: The study aimed at conducting an open, prospective study on various aspects of levetiracetam (LEV) effectiveness in Bulgarian patients with drug-resistant epilepsy.&nbsp; Materials and methods: The study was performed with patients with epilepsy recruited from those attending the Department of Neurology at the University Hospital in Plovdiv, Bulgaria. The patients completed diaries about seizure frequency, severity, and adverse events. There wer

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