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Journal articles on the topic 'Epilepsy Treatment Guidelines'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Saputra, Dedyanto Henky. "Peran Diet Ketogenik dalam Tata Laksana Epilepsi." Cermin Dunia Kedokteran 49, no. 11 (2022): 629–34. http://dx.doi.org/10.55175/cdk.v49i11.318.

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Sejak diperkenalkan pertama kali pada awal abad 19, penggunaan diet ketogenik dalam terapi epilepsi terus berkembang, khususnya untuk kasus epilepsi yang refrakter terhadap terapi farmakologi. Berbagai mekanisme terkait peran diet ketogenik dalam memperbaiki kondisi epilepsi telah diajukan, mulai keterlibatannya dalam regulasi GABA dan glutamat, efek antioksidan, perbaikan metabolisme energi, hingga koreksi kondisi disbiosis. Diet ketogenik adalah terapi non-farmakologis epilepsi yang menjanjikan, saat ini telah masuk dalam guideline NICE di Inggris untuk kasus epilepsi anak yang resisten terh

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2

Stern, John M. "Overview of treatment guidelines for epilepsy." Current Treatment Options in Neurology 8, no. 4 (2006): 280–88. http://dx.doi.org/10.1007/s11940-006-0018-6.

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3

Hakami, Tahir. "Efficacy and tolerability of antiseizure drugs." Therapeutic Advances in Neurological Disorders 14 (January 2021): 175628642110374. http://dx.doi.org/10.1177/17562864211037430.

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Drug-resistant epilepsy occurs in 25–30% of patients. Furthermore, treatment with a first-generation antiseizure drug (ASD) fails in 30–40% of individuals because of their intolerable adverse effects. Over the past three decades, 20 newer- (second- and third-)generation ASDs with unique mechanisms of action and pharmacokinetic profiles have been introduced into clinical practice. This advent has expanded the therapeutic armamentarium of epilepsy and broadens the choices of ASDs to match the individual patient’s characteristics. In recent years, research has been focused on defining the ASD of

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4

Wang, Zhijie, Yu Zhang, Wei Guo, Xiaoyang Mio Hu, Xiao Gao, and Liming Lu. "Reporting specifications regarding epilepsy practice guidelines based on the RIGHT reporting checklist: an analysis." BMJ Open 9, no. 12 (2019): e029589. http://dx.doi.org/10.1136/bmjopen-2019-029589.

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ObjectiveClinical guidelines are designed to optimise patient care and provide efficient approaches for therapy. Epilepsy is a chronic brain disorder that continues to experience a considerable treatment gap due to non-standard recommendations. We assessed the reporting quality of clinical practice guidelines on epilepsy over the past 5 years to generate a reporting specification for this study.SettingSeven databases were searched in May 2018 focusing on the period from 2013 to 2018. These included Medline, EMBASE, PubMed, Cumulative Index to Nursing and Allied Health Literature, China Nationa

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5

Shin, Dong Jin, Young-Min Shon, Ki-Young Jung, et al. "Practical Drug Treatment Recommendations on the Drug Refractory Epilepsy Patients: 2021 Clinical Guideline Subcommittee for Epilepsy in the Korean Neurological Association." Journal of the Korean Neurological Association 39, no. 4 (2021): 255–69. http://dx.doi.org/10.17340/jkna.2021.4.1.

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One third of the overall epilepsy population are estimated to be a drug refractory epilepsy (DRE), defined as the patients who failed to control seizure reduction, even tried two or more appropriate antiepileptic drugs (AEDs) trials. Those people need additional AEDs trials or other treatment options (resective surgery, neuromoulation, etc.). Here, we, clinical guideline committee of the Korean Neurological Association (KNA) introduce the recommendations of AEDs treatments including not only old and new AEDs currently available in Korea but also AEDs planned to be launched in the new future fo

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6

Koch-Stoecker, Steffi. "Antipsychotic Drugs and Epilepsy: Indications and Treatment Guidelines." Epilepsia 43 (March 19, 2002): 19–24. http://dx.doi.org/10.1046/j.1528-1157.2002.043s2019.x.

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7

Stern, John M. "Overview of evaluation and treatment guidelines for epilepsy." Current Treatment Options in Neurology 11, no. 4 (2009): 273–84. http://dx.doi.org/10.1007/s11940-009-0031-7.

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8

Harden, Cynthia L., David L. Ginsberg, Andres M. Kanner, Jocelyn F. Bautista, and Thomas R. Browne. "Treatment-Refractory Epilepsy: An Evidence-Based Approach to Antiepileptic Monotherapy." CNS Spectrums 10, S3 (2005): 1–16. http://dx.doi.org/10.1017/s1092852900026596.

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AbstractTreatment options for epilepsy have increased in the last decade with the introduction of several new antiepileptic drugs (AEDs). As drug selection becomes more challenging, the use of evidence-based guidelines to aid in treatment decisions has become increasingly valued. The American Academy of Neurology's (AAN) guidelines for the use of new AEDs in refractory epilepsy offers many benefits, including expert panel recommendations based on clinically relevant questions with evidence-based responses. However, lack of evidence from randomized-controlled trials, particularly as they relate

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9

Guerreiro, Carlos A. M. "Guidelines for drug treatment of epilepsy: a critical review." Arquivos de Neuro-Psiquiatria 66, no. 3a (2008): 591–99. http://dx.doi.org/10.1590/s0004-282x2008000400036.

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This article critically reviews the role of evidence-based medicine and its guidelines, from their logistic preparation to their interpretation. The strengths and weaknesses of the methodological points are presented, as well the reasons for the extreme popularity of the guidelines in developed countries. The review discusses the main foundations of the most cited guidelines and some recent large studies. Some of the final conclusions are that clinical experience is always an important factor to consider, even in the face of solid evidence, to achieve the best possible management of any partic

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Birbeck, Gretchen L., Elwyn Chomba, Edward Mbewe, Masharip Atadzhanov, Alan Haworth, and Henry Kansembe. "The cost of implementing a nationwide program to decrease the epilepsy treatment gap in a high gap country." Neurology International 4, no. 3 (2012): 14. http://dx.doi.org/10.4081/ni.2012.e14.

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Healthcare systems in many low income countries have evolved to provide services for acute, infections and are poorly structured for the provision of chronic, non-communicable diseases which are increasingly common. Epilepsy is a common chronic neurologic condition and antiepileptic drugs are affordable, but the epilepsy treatment gap remains &gt;90% in most African countries. The World Health Organization has recently released evidence-based guidelines for epilepsy care provision at the primary care level. Based upon these guidelines, we estimated all direct costs associated with epilepsy

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11

Riese, Franziska, Nina Meyerhoff, Jasmin Nessler, and Andrea Tipold. "Misery of insufficient treatment guidelines in post-traumatic epilepsy." Veterinary Record Case Reports 7, no. 3 (2019): e000716. http://dx.doi.org/10.1136/vetreccr-2018-000716.

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Two dogs were presented after traumatic brain injury (TBI): a Jack Russell Terrier (JRT) kicked by a horse and a Magyar Vizsla (MV) hit by train. Both dogs developed seizures immediately after trauma and were treated successfully with antiepileptic drugs (AEDs) for 1 month (JRT) with imepitoin and for half a year (MV) with phenobarbital. After discontinuing the antiepileptic therapy, both dogs developed seizures again resulting in death of the JRT in status epilepticus. The MV was treated again with AEDs and continued to have cluster seizures every 2 weeks. In conclusion, it can be recommended

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12

Aylward, R. "Epilepsy." Journal of the Royal College of Physicians of Edinburgh 36, no. 4 (2006): 326–31. https://doi.org/10.1177/1478271520063604011.

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Epilepsy is common and has a variety of causes. This article discusses the aetiology of the epilepsies, particularly the genetic causes, and provides up-todate information on how the condition should be diagnosed, classified, and treated. Some guidance is provided about tailoring the choice of drug treatment according to classification, and the best approach to treatment during pregnancy. Recent data from the UK Epilepsy and Pregnancy register are included. The management of patients with particularly severe and intractable epilepsies is discussed as well as the latest guidelines on the manage

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13

Chtibi, M., H. Zarouf, I. Hanine, S. Belbachir, and A. Ouanass. "Ultra-Resistant Schizophrenia Comorbid with Temporal Epilepsy: A Case Report." Scholars Journal of Medical Case Reports 11, no. 09 (2023): 1603–7. http://dx.doi.org/10.36347/sjmcr.2023.v11i09.009.

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Resistant schizophrenia is a significant public health issue due to high treatment costs and institutional dependence of patients. Despite the various definitions currently available to define resistant schizophrenia, along with existing clinical guidelines, their impact on daily clinical practice remains limited. While clozapine has been endorsed by national clinical guidelines, its utilization remains suboptimal, with delays in initiation and instances of ineffectiveness. Ultra-resistant schizophrenia is defined by clozapine's inefficacy even after a well-conducted treatment. The relationshi

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14

Tenney, Jeffrey R. "Epilepsy—Work-Up and Management in Children." Seminars in Neurology 40, no. 06 (2020): 638–46. http://dx.doi.org/10.1055/s-0040-1718720.

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AbstractPediatric epilepsy is a highly variable condition due to age-related expression of syndromes that require specific diagnosis, evaluations, and treatments. Children with epilepsy differ from their adult counterparts in many important ways, mostly related to the age-related expression of specific epilepsy syndromes. This results in many important considerations related to the epilepsy diagnosis, classification, evaluations to determine an etiology, as well as treatment guidelines. A good understanding of these factors will help to establish an accurate epilepsy diagnosis, which in turn w

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Walsh, Kelda, and David Dunn. "Anxiety in Children and Adolescents with Epilepsy." Journal of Pediatric Epilepsy 07, no. 03 (2018): 097–102. http://dx.doi.org/10.1055/s-0038-1676537.

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AbstractAnxiety is a common comorbidity in children with epilepsy, though often overlooked and undertreated. Fear and worry are common reactions of children with epilepsy and their parents. Risk factors are multiple and include demographical, epilepsy-related, genetic, and family variables. Anxiety negatively affects health-related quality of life (QOL) and may contribute to poor seizure control. Appropriate treatment of anxiety in children with epilepsy should follow practice guidelines developed for treatment of anxiety in children without epilepsy and consist of education, counseling, and p

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Zheng, Yongsu, Nian Wei, Jian Wang, Hui Dai, and Zucai Xu. "Anti-Hu-related epilepsy diagnosed after surgical management." Journal of International Medical Research 48, no. 8 (2020): 030006052094791. http://dx.doi.org/10.1177/0300060520947914.

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Autoimmune epilepsy (AE) refers to epilepsy mediated by autoantibodies or immune cells, and a large proportion of drug-resistant epilepsy cases are classified as AE. AE lacks standardized management guidelines. At present, little research has been conducted on the effectiveness of surgical treatment of AE. This paper reports a patient whose surgical treatment was ineffective before AE was diagnosed and who improved after immunotherapy. A literature review was conducted to examine the progress of surgical treatment of epilepsy, the relationship of temporal lobe epilepsy to neuronal antibodies,

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van der Feltz-Cornelis, Cm. "Treatment of interictal psychiatric disorder in epilepsy. I. Affective and anxiety disorders." Acta Neuropsychiatrica 14, no. 1 (2002): 39–43. http://dx.doi.org/10.1034/j.1601-5215.2002.140106.x.

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Background:Interictal affective disorders are common in patients with epilepsy and there is a need for evidence-based treatment guidelines.Objective:This paper gives an overview of research concerning treatment of interictal affective disorders and interictal anxiety disorders in epilepsy.Methods:Literature review supplemented by clinical experience.Results:Interictal psychiatric disorder can be characterized as intermittent pleomorphic psychopathology. The most common manifestations are interictal dysphoric disorder (IDD) and depression. There is a lack of randomized control trials (RCTs) con

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Agrawal, Niruj, and Marco Mula. "Treatment of psychoses in patients with epilepsy: an update." Therapeutic Advances in Psychopharmacology 9 (January 2019): 204512531986296. http://dx.doi.org/10.1177/2045125319862968.

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Psychotic disorders represent a relatively rare but serious comorbidity in epilepsy. Current epidemiological studies are showing a point prevalence of 5.6% in unselected samples of people with epilepsy going up to 7% in patients with temporal lobe epilepsy, with a pooled odds ratio of 7.8 as compared with the general population. This is a narrative review of the most recent updates in the management of psychotic disorders in epilepsy, taking into account the clinical scenarios where psychotic symptoms occur in epilepsy, interactions with antiepileptic drugs (AEDs) and the risk of seizures with

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19

SCHERER, A. "New guidelines on the treatment of epilepsy with the new antiepileptic drugsFrom the Epilepsy Foundation." Epilepsy & Behavior 5, no. 4 (2004): 433–34. http://dx.doi.org/10.1016/s1525-5050(04)00158-1.

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20

Kanner, Andres M., Eric Ashman, David Gloss, et al. "Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy." Neurology 91, no. 2 (2018): 82–90. http://dx.doi.org/10.1212/wnl.0000000000005756.

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ObjectiveTo update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs).Methods2004 criteria were used to systemically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength.ResultsForty-two articles were included.RecommendationsThe following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy

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21

Knieß, Tobias, Hermann Stefan, and Peter Brodisch. "Diagnosis of epilepsy – consequences for work and professional activities." Journal of Epileptology 23, no. 2 (2015): 103–12. http://dx.doi.org/10.1515/joepi-2015-0032.

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Summary Introduction. The correct diagnosis of epileptic seizures and non-epileptic attacks has a decisive influence on treatment, counseling and duration of possible work limitations. Diagnostic efforts should aim towards classifying the seizure as precisely as possible. For risk assessments, e.g. at the workplace, a close cooperation and networking of all professionals involved in the epilepsy treatment, care and consultation processes is required. Aim. To present guidelines for assessment of occupational capacity of persons with epilepsy and to discuss their value in clinical practice. Meth

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Kanner, Andres M., Eric Ashman, David Gloss, et al. "Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy." Epilepsy Currents 18, no. 4 (2018): 269–78. http://dx.doi.org/10.5698/1535-7597.18.4.269.

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Objective: To update the 2004 American Academy of Neurology (AAN) guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). Methods: 2004 criteria were used to systematically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. Results: Forty-two articles were included. Recommendations: The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR ad

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23

Smith, Nicola, and Divya Tiwari. "Epilepsy in older people." Reviews in Clinical Gerontology 25, no. 1 (2015): 53–59. http://dx.doi.org/10.1017/s0959259815000052.

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SummaryEpilepsy is the third most common neurological disorder of older adults, with huge functional and psychological implications. It is often difficult to diagnose in the presence of cognitive impairment and lack of a witness account. The most common identifiable causes of epilepsy in old age are cerebrovascular disease and dementia. New guidelines recommend starting treatment after first unprovoked seizure. If there is any doubt about the diagnosis, electroencephalography (EEG) should be considered, or ‘wait and watch’. The aim of treatment should be to fully control seizure activity with

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Culler, George W., and Stephen VanHaerents. "Immunologic Treatments of Seizures and Status Epilepticus." Seminars in Neurology 40, no. 06 (2020): 708–18. http://dx.doi.org/10.1055/s-0040-1719111.

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AbstractAn autoimmune etiology for seizures, epilepsy, and status epilepticus is becoming increasingly recognized. The role of autoimmunity in epilepsy has been highlighted in the literature and the International League Against Epilepsy now recognizes autoimmune epilepsy as a distinct entity. An appropriate and thorough work-up of all new-onset seizures and status epilepticus is paramount in determining the likely efficacy of immunotherapeutic agents in treating seizures and status epilepticus. Criteria for the clinical diagnosis of autoimmune mediated epilepsy and encephalitis have been publi

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van der Feltz-Cornelis, Cm. "Treatment of interictal psychiatric disorder in epilepsy. II. Chronic psychosis." Acta Neuropsychiatrica 14, no. 1 (2002): 44–48. http://dx.doi.org/10.1034/j.1601-5215.2002.140107.x.

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Background:Interictal psychosis is a serious comorbid condition in epilepsy patients that would benefit from treatment with psychotropic medication.Objective:This paper gives an overview of the pathophysiology, symptomatology and treatment of the schizophrenia-like psychosis of epilepsy. Use of the term ‘interictal chronic psychosis’ is suggested, to conform to current DSM-IV classification of schizophrenia.Methods:Literature review supplemented by clinical experience. There is a lack of randomized control trials (RCTs) concerning effectiveness and side-effects of neuroleptics in epilepsy pati

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Shankar, Rohit, Caryn Jory, juliet ashton, Brendan McLean, and Matthew Walker. "Epilepsy emergency rescue training." BMJ Quality Improvement Reports 4, no. 1 (2015): u208167.w3566. http://dx.doi.org/10.1136/bmjquality.u208167.w3566.

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AbstractThe NICE audit of epilepsy related deaths revealed that 1200 epilepsy deaths occur every year in the UK, with 42% potentially avoidable.[1] Convulsive status epilepticus (SE) is a life-threatening condition with over 20% mortality rate, especially if early treatment is not initiated .[2] Ten percent of all UK emergency department (ED) admissions are due to epilepsy, usually over represented by cases of SE.[3] Six out of seven epilepsy cases seen in the ED are admitted into medical care.[4]Patients with chronic and/or treatment resistant epilepsy carry a higher risk of premature death.

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Gauci, Maria Cristina, Rosaria Gauci, Martino Ruggieri, Agata Polizzi, and Andrea D. Praticò. "Clinical, Genetic, EEG, Neuroimaging Insights and Conservative Treatment in Pediatric Focal Epilepsy: A Retrospective Observational Study." Journal of Clinical Medicine 14, no. 7 (2025): 2234. https://doi.org/10.3390/jcm14072234.

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Objective: Focal epilepsy is the most frequent type of epilepsy in childhood, particularly after the first year of life. This study aims to analyze the clinical aspects, electrophysiological and neuroimaging findings, and genetic predispositions in pediatric focal epilepsy. Specifically, we investigate the association between these parameters and evaluate their impact on therapeutic decisions. Methods: This is a retrospective study, in which we enrolled 39 patients currently receiving follow-up in our unit, 20 male and 19 female. Using the Chi-squared test, we compared them considering several

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Johnstone, Ross J., and Michael J. S. Morton. "Specialist mental healthcare for children with epilepsy: child and adolescent mental health service liaison with neuroscience." Psychiatric Bulletin 33, no. 10 (2009): 384–86. http://dx.doi.org/10.1192/pb.bp.108.021139.

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Aims and MethodTo describe services used by children with epilepsy seen by a liaison psychiatry team in Scotland and to examine existing guidance. Case notes of all patients with epilepsy were systematically reviewed to determine service involvement.ResultsThe majority of patients attended joint psychiatry and neurology clinics. Scottish Intercollegiate Guidelines Network (SIGN) recommendations for the psychosocial management of children with epilepsy were met. Most patients were assessed by a clinical psychologist and received educational psychology input, individual and family treatment appr

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Ułamek-Kozioł, Marzena, Stanisław J. Czuczwar, Sławomir Januszewski, and Ryszard Pluta. "Ketogenic Diet and Epilepsy." Nutrients 11, no. 10 (2019): 2510. http://dx.doi.org/10.3390/nu11102510.

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Currently available pharmacological treatment of epilepsy has limited effectiveness. In epileptic patients, pharmacological treatment with available anticonvulsants leads to seizure control in <70% of cases. Surgical intervention can lead to control in a selected subset of patients, but still leaves a significant number of patients with uncontrolled seizures. Therefore, in drug-resistant epilepsy, the ketogenic diet proves to be useful. The purpose of this review was to provide a comprehensive overview of what was published about the benefits of ketogenic diet treatment in patients with epi

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Caramelli, Paulo, and Luiz Henrique Martins Castro. "Dementia associated with epilepsy." International Psychogeriatrics 17, s1 (2005): S195—S206. http://dx.doi.org/10.1017/s1041610205002024.

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In this review, we explore the relationship between epilepsy and cognition and between epilepsy and dementia. Chronic epilepsy, particularly mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis, may be associated with impaired cognition, which can be secondary to uncontrolled seizures, to adverse effects of antiepileptic drugs (AEDs) or to the underlying biological abnormality. The choice of an adequate AED with an appropriate dose regimen may lead to a favorable outcome. This feature is especially relevant in elderly patients with dementia and associated epilepsy, a vulnerable popu

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George, Ilena C., Luca Bartolini, John Ney, and Divya Singhal. "Differences in treatment of epilepsy in pregnancy." Neurology: Clinical Practice 9, no. 3 (2019): 201–7. http://dx.doi.org/10.1212/cpj.0000000000000642.

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BackgroundHow to safely treat pregnant women with epilepsy is a question for which there are guidelines, but variations in practice exist.MethodsTo better characterize how clinicians address this difficult clinical question, we distributed an anonymous survey to neurology practitioners across subspecialties and different levels of training via the Neurology®: Clinical Practice website. The survey was conducted from May 31 to December 3, 2017. We received responses from 642 participants representing 81 countries. We performed both descriptive and inferential analyses. For the inferential analys

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Zachaj, Jakub, Zuzanna Tomczewska, and Marta Rybińska. "Management of seizures in children in primary health care." Pediatria i Medycyna Rodzinna 19, no. 1 (2023): 12–20. http://dx.doi.org/10.15557/pimr.2023.0002.

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Sudden health states accompanied by seizures require proper diagnosis and appropriate treatment. A seizure in the paediatric population may turn into a life-threatening condition, especially when it is misdiagnosed and appropriate management is initiated too late. The article presents the classification of seizures proposed by the International League Against Epilepsy and seizure time intervals when appropriate treatment should be implemented. The main part of this work is the description of non-pharmacological treatment. In this paper, the management of seizures in the paediatric population w

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Areshkina, Irina G., Yuri V. Mozheiko, Anna A. Usoltseva, Nikita P. Utyashev, Violetta D. Poleshchuk, and Diana V. Dmitrenko. "Withdrawal of Antiepileptic Drugs Following Surgical Treatment of Drug-Resistant Epilepsy." Annals of Clinical and Experimental Neurology 19, no. 2 (2025): 87–102. https://doi.org/10.17816/acen.1262.

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The number of patients with successful outcomes following surgical treatment of drug-resistant epilepsy has been rapidly increasing. This trend has heightened the relevance of addressing the appropriateness of postoperative withdrawal of antiepileptic drugs (AED). There are no unified guidelines regarding the optimal timing and rates for discontinuing pharmacological therapy. This article reviews the timing, rate, and specifics of AED withdrawal following surgical treatment of drug-resistant epilepsy using two exemplary clinical cases. The decision to discontinue pharmacotherapy depends on mul

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Seaborg, Kristin, Kelly Faltersack, and Elizabeth A. Felton. "Transition of Care for Adolescent and Young Adult Patients on Dietary Therapy for Epilepsy." Journal of Pediatric Epilepsy 09, no. 04 (2020): 114–18. http://dx.doi.org/10.1055/s-0040-1716550.

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AbstractKetogenic diets are high-fat, low-carbohydrate diets designed to alter metabolism, induce nutritional ketosis, and reduce seizures in patients with epilepsy. In the past 15 to 20 years, the diets have been refined, gaining momentum in the treatment of resistant epilepsy. As ketogenic diets have gained popularity for treatment of pediatric epilepsies, an increasing number of adolescents treated with dietary therapy are approaching the age of transitioning their care to adult providers. Transition of care for this vulnerable population brings unique challenges posed by a paucity of adult

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Rana, Mandeep, Alcy R. Torres, Kam Lun Hon, Alexander K. C. Leung, and Rinat Jonas. "Febrile Infection-Related Epilepsy Syndrome." Journal of Pediatric Epilepsy 08, no. 03 (2019): 083–92. http://dx.doi.org/10.1055/s-0039-1701035.

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AbstractFebrile infection-related epilepsy syndrome (FIRES) is a subset or variant of new-onset refractory status epilepticus in children. FIRES is characterized by the occurrence of a febrile episode between 24 hours and 2 weeks before the onset of refractory status epilepticus. A infectious cause is rarely identified in FIRES and an inflammatory or autoimmune etiology is implied. Seizures in FIRES are very difficult to control, and treatments include antiepileptic drugs, ketogenic diet, intravenous immunoglobulin, plasmapheresis, and corticosteroid therapy. The prognosis for patients with FI

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Scherer, A. "New guidelines on the treatment of epilepsy with the new antiepileptic drugs." Epilepsy & Behavior 5, no. 4 (2004): 433–34. http://dx.doi.org/10.1016/j.yebeh.2004.05.004.

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Baxendale, Sallie. "Neuropsychological assessment in epilepsy." Practical Neurology 18, no. 1 (2018): 43–48. http://dx.doi.org/10.1136/practneurol-2017-001827.

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The role of the neuropsychological assessment in the management of people with epilepsy has evolved considerably over the past 25 years. This paper describes some of the most common applications of a neuropsychological assessment in the diagnosis, management and treatment of people with epilepsy. It describes the factors that influence the interpretation of neuropsychological test scores in this patient group and outlines the limitations of the investigation. It gives guidelines for the optimal timing of a referral, together with timelines and indications for reassessment, and provides a check

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Coppola, Giangennaro, Frank Besag, Raffaella Cusmai, et al. "Current role of rufinamide in the treatment of childhood epilepsy: Literature review and treatment guidelines." European Journal of Paediatric Neurology 18, no. 6 (2014): 685–90. http://dx.doi.org/10.1016/j.ejpn.2014.05.008.

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Sasaki, Takahiro, Yasuo Nakai, Junya Fukai, and Naoyuki Nakao. "10066- MET-7 RISK FACTORS FOR THE EPILEPSY IN PATIENTS WITH BRAIN METASTASES." Neuro-Oncology Advances 6, Supplement_4 (2024): iv21. http://dx.doi.org/10.1093/noajnl/vdae173.081.

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Abstract In accordance with the progress of cancer treatment, there is a need for long-term control of epilepsy that develops in metastatic brain tumors. In this study, we examined risk factors for the development of epilepsy in metastatic brain tumors. We retrospectively analyzed 200 patients with metastatic brain tumors treated between January 2010 and December 2023 for clinical information such as tumor site, imaging features, genetic mutations, and treatment details. Overall, median age was 67 years, 112 (56%) were male, and the major primary sites were non-small cell lung cancer (55%), br

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Ayaz, Marium, Atif Ali, Rashida Bibi, et al. "Retrospective evaluation of prescribing pattern and utilization of antiepileptic drugs in pediatric, neurosurgery, and psychiatry wards: A comparative study to the standard treatment guidelines." Medicine 103, no. 40 (2024): e39818. http://dx.doi.org/10.1097/md.0000000000039818.

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Antiepileptic drugs (AED) are progressively utilized for off-label conditions other than epilepsy, like bipolar disorder and migraine. The objective of this study was to evaluate current prescribing patterns and utilization of AED in pediatric, neurosurgery, and psychiatry wards and to compare them to the standard treatment guidelines. A descriptive, cross-sectional study was conducted in Ayyub Teaching Hospital, Abbottabad from December 1st, 2018 to April 2019. Data on demographic and clinical characteristics, utilization patterns of AED, adherence to standard treatment guidelines, and freque

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Gugała-Iwaniuk, Magdalena, and Ksenia Sławińska. "The role of neuropsychological examination in the diagnosis and treatment of adult patients with epilepsy." Aktualności Neurologiczne 21, no. 1 (2021): 24–29. http://dx.doi.org/10.15557/an.2021.0003.

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Individuals with epilepsy may experience various difficulties in cognitive and emotional functioning. The neuropsychological examination plays a significant role in the diagnosis and management of patients with epilepsy. It should be conducted by psychologists with appropriate competencies and experience, preferably by specialists who have undergone dedicated training in clinical psychology and gained clinical experience with neurological patients. Conclusions from neuropsychological examination provide information about the influence of epilepsy on cognitive and behavioral functioning of the

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Stimmel, Glen L., and Mary A. Gutierrez. "Pharmacologic Treatment Strategies for Sexual Dysfunction in Patients with Epilepsy and Depression." CNS Spectrums 11, S9 (2006): 31–37. http://dx.doi.org/10.1017/s1092852900026742.

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AbstractSexual dysfunction is a frequently encountered comorbid condition in patients with many medical and psychiatric conditions, such as epilepsy and depression. Most depressed patients experience some type of sexual dysfunction, decreased sexual desire being the most common. The association of sexual dysfunction with epilepsy is less clear. Changes in sex hormone levels are common in patients with epilepsy and may be attributable to the disease or to antiepileptic drugs (AEDs). Sexual dysfunction associated with depression or epilepsy is generally treated according to standard guidelines f

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Vacher, Elizabeth, Miguel Rodriguez Ruiz, and Jeremy Rees. "Developing guidelines for the management of brain tumour related epilepsy." Neuro-Oncology 23, Supplement_4 (2021): iv3—iv4. http://dx.doi.org/10.1093/neuonc/noab195.007.

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Abstract Aims Brain Tumour Related Epilepsy (BTRE) has a significant impact on Quality of Life with implications for driving, employment and social and domestic activities. Management of BTRE is complex due to the higher incidence of pharmacoresistance and the potential for interaction between anti-cancer therapy and anti-epileptic drugs (AEDs). Neurologists, oncologists, palliative care physicians and clinical nurse specialists treating these patients would benefit from up-to-date clinical guidelines. We aim to review the current evidence to adapt current NICE guidelines for Epilepsy and to o

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Ott, U., K. Hegmann, M. Thiese, D. Passey, W. Caughey, and Z. Carter. "P149 Development Of Evidence Based Guidelines For The Treatment Of Seizures And Epilepsy." BMJ Quality & Safety 22, Suppl 1 (2013): 60.2–60. http://dx.doi.org/10.1136/bmjqs-2013-002293.180.

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Minicucci, Fabio, Giancarlo Muscas, Emilio Perucca, Giuseppe Capovilla, Federico Vigevano, and Paolo Tinuper. "Treatment of Status Epilepticus in Adults: Guidelines of the Italian League Against Epilepsy." Epilepsia 47, s5 (2006): 9–15. http://dx.doi.org/10.1111/j.1528-1167.2006.00870.x.

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Jah, Sahibzada Zumeran, Amina Javid Qaiser, Myrah Hasan, et al. "EMERGING APPROACHES IN PEDIATRIC EPILEPSY MANAGEMENT: A NARRATIVE REVIEW." Insights-Journal of Life and Social Sciences 3, no. 3 (Life) (2025): 206–12. https://doi.org/10.71000/f2h96f58.

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Background: Pediatric epilepsy is a prevalent neurological disorder that significantly impacts cognitive, behavioral, and psychosocial development in children. While antiseizure medications (ASMs) remain the mainstay of treatment, approximately one-third of pediatric patients experience drug-resistant epilepsy (DRE), highlighting the need for alternative and individualized treatment strategies. Objective: This narrative review aims to explore recent advances in pharmacological and non-pharmacological treatment approaches for pediatric epilepsy, emphasizing emerging therapies such as dietary in

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de Brito Sampaio, Letícia Pereira, Adélia Maria de Miranda Henriques-Souza, Katia Lin, et al. "Ketogenic therapy in childhood and adolescence: recommendations of the Brazilian experts group." Arquivos de Neuro-Psiquiatria 81, no. 06 (2023): 597–606. http://dx.doi.org/10.1055/s-0043-1768676.

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AbstractKetogenic dietary therapies (KDTs) are a safe and effective treatment for pharmacoresistant epilepsy in children. There are four principal types of KDTs: the classic KD, the modified Atkins diet (MAD), the medium-chain triglyceride (MCT) diet, and the low glycemic index diet (LGID). The International Ketogenic Diet Study Group recommends managing KDTs in children with epilepsy. However, there are no guidelines that address the specific needs of the Brazilian population. Thus, the Brazilian Child Neurology Association elaborated on these recommendations with the goal of stimulating and

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Oshiro, Carlos André, and Luiz Henrique Martins Castro. "Cannabidiol and epilepsy in Brazil: a current review." Arquivos de Neuro-Psiquiatria 80, no. 5 suppl 1 (2022): 182–92. http://dx.doi.org/10.1590/0004-282x-anp-2022-s137.

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ABSTRACT Background: Cannabidiol (CBD) has become a promising therapeutic option in the treatment of epilepsy. Recent studies provide robust evidence that CBD is effective and safe. Limitations in current knowledge and regulatory issues still limit CBD use. CBD use regarding epilepsy types still lacks clear guidelines. Objective: To critically review the main current pharmacological features and clinical issues regarding CBD use in epilepsy, to provide current regulatory background regarding CBD use in Brazil, and to suggest a practical CBD therapeutic guide in Brazil. Methods: Non-systematic

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Arbune, Anca-Adriana, Dana Craiu, Iulian Dan Cuciureanu, et al. "Challenges of Valproate Treatment During Pregnancy: Pros and Cons." Revista de Chimie 71, no. 2 (2020): 456–59. http://dx.doi.org/10.37358/rc.20.2.7949.

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Valproic acid and its salt, sodium valproate, are an effective treatment for epilepsy, the most common chronic neurologic disorder worldwide. Teratogenic associations reported after embryofetal exposure has limited the recommendations of valproate use in women of childbearing age, after careful evaluation of the benefits and risks of this medication. The mechanisms of valproate damage during pregnancy are complex and incompletely clarified up to date. Maternal and fetal impact of valproate is a critical issue, standing at the base of the new consensus on practical guidelines for clinical use o

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Hrazdil, C., A. Datta, A. Michoulas, et al. "Utilization of transition care management plans to facilitate transition of adolescents with epilepsy into the adult healthcare system." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 42, S1 (2015): S23. http://dx.doi.org/10.1017/cjn.2015.116.

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Background: For adolescents with epilepsy, there is often a poor system in place to meet their individualized transition needs. Our objectives were 1) to develop epilepsy-specific transition care management plans (TCMPs) to ensure access, and attachment to adult healthcare providers, and 2) to identify strategies for providing support during the transition period, including through the development of physician and patient (or caregiver) navigated web-based tools, resources and recommendations for health system improvements. Methods: Physicians and nurses with expertise in areas including adult

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